MCID: VRS001
MIFTS: 34

Virus Associated Hemophagocytic Syndrome

Categories: Rare diseases

Aliases & Classifications for Virus Associated Hemophagocytic Syndrome

MalaCards integrated aliases for Virus Associated Hemophagocytic Syndrome:

Name: Virus Associated Hemophagocytic Syndrome 50

Classifications:



Summaries for Virus Associated Hemophagocytic Syndrome

NIH Rare Diseases : 50 virus associated hemophagocytic syndromeis a very serious complication of a viral infection. signs and symptoms of virus associated hemophagocytic syndrome, include high fever, liver problems, enlarged liver and spleen, coagulation factor abnormalities, decreased red or white blood cells and platelets (pancytopenia), and a build-up of histiocytes, a type of immune cell, in various tissues in the body resulting in the destruction of blood-producing cells (histiocytic proliferation with prominent hemophagocytosis). diagnosis is based upon the signs and symptoms of the patient. the cause of the condition is not known. treatment is challenging and approach will vary depending on the age and medical history of the patient. complications of this syndrome can become life threatening. related conditions (conditions with overlapping signs and symptoms), include histiocytic medullary reticulosis (hmr), familial hemophagocytic lymphohistiocytosis (fhl), and x-linked lymphoproliferative syndrome. last updated: 5/8/2013

MalaCards based summary : Virus Associated Hemophagocytic Syndrome is related to lymphoma and brain injury. An important gene associated with Virus Associated Hemophagocytic Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are IL-2 Pathway and Influenza A. The drugs Etoposide and Asparaginase have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and t cells, and related phenotype is hematopoietic system.

Related Diseases for Virus Associated Hemophagocytic Syndrome

Diseases related to Virus Associated Hemophagocytic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.0 IL2 IL4
2 brain injury 10.4 IL2 MB
3 x-linked intellectual disability, van esch type 10.4 IL2 IL4
4 pmm2-congenital disorder of glycosylation 10.4 IL2 IL4
5 dioctophymiasis 10.4 IL2 IL4
6 lymphocytic colitis 10.4 IL2 IL4
7 tularemia 10.4 IL2 IL4
8 gonadal disease 10.4 IL2 IL4
9 opitz-kaveggia syndrome 10.4 IL2 IL4
10 acute monoblastic leukemia 10.4 IL2 IL4
11 orbital osteomyelitis 10.3 IL2 IL4
12 inflamed seborrheic keratosis 10.3 IL2 IL4
13 ovarian endometrioid cystadenoma 10.3 IL2 IL4
14 immunodeficiency 11a 10.3 IL2 IL2RB
15 abnormal retinal correspondence 10.3 IL2 IL4
16 central nervous system origin vertigo 10.3 IL2 IL4
17 esophagus melanoma 10.3 IL2 IL4
18 benign mammary dysplasia 10.3 IL2 IL4
19 legionellosis 10.3 IL2 IL4
20 erythema infectiosum 10.3 IL2 IL4
21 corneal intraepithelial neoplasm 10.3 IL2 IL4
22 acute interstitial pneumonia 10.3 IL2 IL4
23 fuchs' heterochromic uveitis 10.3 IL2 IL4
24 endometrial type cervical adenomyoma 10.3 MB PIK3C2A
25 myopathy, distal, tateyama type 10.3 MB PIK3C2A
26 velocardiofacial syndrome 10.3 MB PIK3C2A
27 inferior myocardial infarction 10.3 MB PIK3C2A
28 opportunistic bacterial infectious disease 10.2 IL2 IL4
29 hereditary choroidal atrophy 10.2 MB PIK3C2A
30 glomerulonephritis 10.2 MB PIK3C2A
31 mucocutaneous leishmaniasis 10.2 IL2 IL4
32 adenocarcinoma 10.2 MB PIK3C2A
33 blue toe syndrome 10.2 IL2 IL4
34 brachial plexus neuropathy 10.2 MB PIK3C2A
35 rete ovarii adenoma 10.2 MB PIK3C2A
36 chorea gravidarum 10.2 MB PIK3C2A
37 malignant hyperthermia 10.2 IL2 IL4
38 parasitic helminthiasis infectious disease 10.2 MB PIK3C2A
39 mesenchymal cell neoplasm 10.2 IL2 IL4
40 microphthalmia, isolated, with coloboma 7 10.2 MB PIK3C2A
41 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2 MB PIK3C2A
42 polysyndactyly trigonocephaly agenesis of corpus callosum 10.2 MB PIK3C2A
43 childhood cerebellar astrocytic neoplasm 10.2 IL2 IL4
44 angioid streaks of choroid 10.2 IL4 PIK3C2A
45 mitochondrial dna depletion syndrome 12 10.2 MB PIK3C2A
46 uterus interstitial leiomyoma 10.2 IL2 IL4
47 oropharynx cancer 10.2 MB PIK3C2A
48 acute liver failure 10.2 MB PIK3C2A
49 hyperpigmentation of eyelid 10.2 IL2 IL4
50 ostertagiasis 10.1 IL4 PIK3C2A

Graphical network of the top 20 diseases related to Virus Associated Hemophagocytic Syndrome:



Diseases related to Virus Associated Hemophagocytic Syndrome

Symptoms & Phenotypes for Virus Associated Hemophagocytic Syndrome

MGI Mouse Phenotypes related to Virus Associated Hemophagocytic Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 IL2RB IL4 MB PIK3C2A CD68 IL2

Drugs & Therapeutics for Virus Associated Hemophagocytic Syndrome

Drugs for Virus Associated Hemophagocytic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Asparaginase Approved Phase 3 9015-68-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
4
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Pegaspargase Approved, Investigational Phase 3 130167-69-0
7
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
8
Doxil Approved June 1999 Phase 3 31703
9 Antineoplastic Agents, Phytogenic Phase 3
10 Etoposide phosphate Phase 3
11 Topoisomerase Inhibitors Phase 3
12 Anti-Bacterial Agents Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Antiemetics Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Autonomic Agents Phase 3
18 BB 1101 Phase 3
19 Dexamethasone acetate Phase 3 1177-87-3
20 Gastrointestinal Agents Phase 3
21 glucocorticoids Phase 3
22 HIV Protease Inhibitors Phase 3
23 Hormone Antagonists Phase 3
24 Hormones Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
26 Methylprednisolone acetate Phase 3
27 Methylprednisolone Hemisuccinate Phase 3
28 Neuroprotective Agents Phase 3
29 Peripheral Nervous System Agents Phase 3
30 Prednisolone acetate Phase 3
31 Prednisolone hemisuccinate Phase 3
32 Prednisolone phosphate Phase 3
33
protease inhibitors Phase 3
34 Protective Agents Phase 3
35
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
36
alemtuzumab Approved, Investigational Phase 2 216503-57-0
37
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
38 Alkylating Agents Phase 2
39 Anti-Infective Agents Phase 2
40 Antimetabolites Phase 2
41 Antimetabolites, Antineoplastic Phase 2
42 Antirheumatic Agents Phase 2
43 Immunosuppressive Agents Phase 2
44 Antiviral Agents Phase 2
45
Busulfan Approved, Investigational 55-98-1 2478
46
Lenograstim Approved 135968-09-1
47
Methotrexate Approved 1959-05-2, 59-05-2 126941
48
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
49
Prednisone Approved, Vet_approved 53-03-2 5865
50
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 L-DEP as an Initial Treatment for EBV-HLH Recruiting NCT02912702 Phase 3 Pegaspargase;doxorubicin hydrochloride liposome injection;etoposide;methylprednisolone;Etoposide;dexamethasone
2 T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts Recruiting NCT00368355 Phase 2 Ara-C;Cyclophosphamide
3 CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene Active, not recruiting NCT00710892 Phase 1
4 Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders Unknown status NCT00006056 anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;filgrastim;methotrexate
5 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054 anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;methotrexate;methylprednisolone;prednisone

Search NIH Clinical Center for Virus Associated Hemophagocytic Syndrome

Genetic Tests for Virus Associated Hemophagocytic Syndrome

Anatomical Context for Virus Associated Hemophagocytic Syndrome

MalaCards organs/tissues related to Virus Associated Hemophagocytic Syndrome:

39
Liver, Spleen, T Cells, Bone Marrow, Bone

Publications for Virus Associated Hemophagocytic Syndrome

Articles related to Virus Associated Hemophagocytic Syndrome:

(show top 50) (show all 91)
id Title Authors Year
1
Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. ( 27496079 )
2016
2
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection. ( 27883370 )
2016
3
Virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. ( 25838952 )
2015
4
P488. Virus associated hemophagocytic syndrome: rare but serious complication of azathioprine treatment in patients with CrohnA' s disease. ( 25717983 )
2015
5
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome. ( 25941132 )
2015
6
BK virus-associated hemophagocytic syndrome in a renal transplant recipient. ( 24821160 )
2014
7
Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome. ( 23991898 )
2013
8
Ocular findings in a patient with virus-associated hemophagocytic syndrome. ( 22486263 )
2012
9
A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome. ( 22286408 )
2012
10
Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient. ( 22185972 )
2012
11
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. ( 21628863 )
2011
12
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. ( 21366922 )
2011
13
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. ( 20348529 )
2010
14
Dengue virus associated hemophagocytic syndrome in children: a case report. ( 20853575 )
2010
15
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. ( 19640781 )
2009
16
Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. ( 19571453 )
2009
17
Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. ( 19795003 )
2009
18
Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis. ( 19561991 )
2008
19
Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. ( 17703994 )
2007
20
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. ( 17893313 )
2007
21
Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. ( 17456768 )
2007
22
Late-onset fatal Epstein-Barr virus-associated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia. ( 17189228 )
2006
23
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). ( 17106167 )
2006
24
Cyclosporin neurotoxicity with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15753052 )
2005
25
Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS. ( 15897649 )
2005
26
Epstein-Barr virus-associated hemophagocytic syndrome as first presentation of Fanconi anemia. ( 15926162 )
2005
27
Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. ( 15754587 )
2005
28
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis. ( 15625619 )
2005
29
Mumps virus-associated hemophagocytic syndrome. ( 15759337 )
2005
30
Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15465418 )
2004
31
Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a non-compromised host; a case report of unusual entity. ( 15086189 )
2004
32
Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12767005 )
2003
33
Unusual clinical manifestation of virus-associated hemophagocytic syndrome. ( 14708643 )
2003
34
Viral load in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12363023 )
2002
35
Sequential quantification of Epstein-Barr virus DNA in a case of Epstein-Barr virus-associated hemophagocytic syndrome. ( 12416743 )
2002
36
Epstein-Barr virus-associated hemophagocytic syndrome masquerading as lymphoma: a case report. ( 11456362 )
2001
37
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. ( 11475151 )
2001
38
No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan. ( 11536244 )
2001
39
CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. ( 10954276 )
2000
40
Clinicopathological findings of virus-associated hemophagocytic syndrome in bone marrow: association with Epstein-Barr virus and apoptosis. ( 10469396 )
1999
41
Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection. ( 10367794 )
1999
42
Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia. ( 9880630 )
1998
43
Virus-associated hemophagocytic syndrome after hepatic resection: a case report. ( 9496516 )
1998
44
Therapy-related AML after successful chemotherapy with low dose etoposide for virus-associated hemophagocytic syndrome. ( 9846019 )
1998
45
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. ( 9766697 )
1998
46
Epstein Barr virus associated hemophagocytic syndrome--a case report. ( 9364304 )
1997
47
Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome. ( 9444599 )
1997
48
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. ( 9498706 )
1997
49
Epstein-Barr virus--Associated hemophagocytic syndrome. A cause of fever of unknown origin in human immunodeficiency virus infection. ( 9278614 )
1997
50
Epstein-Barr virus induced virus-associated hemophagocytic syndrome and monoclonal TCR-beta rearrangement: a case report. ( 9378473 )
1997

Variations for Virus Associated Hemophagocytic Syndrome

Expression for Virus Associated Hemophagocytic Syndrome

Search GEO for disease gene expression data for Virus Associated Hemophagocytic Syndrome.

Pathways for Virus Associated Hemophagocytic Syndrome

Pathways related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 IL2 IL2RB IL4 PIK3C2A
2
Show member pathways
12.44 IL2 IL2RB IL4
3
Show member pathways
12.43 IL2 IL2RB IL4
4
Show member pathways
12.24 IL2 IL2RB IL4
5 12.18 IL2 IL2RB IL4
6
Show member pathways
12.01 IL2 IL2RB PIK3C2A
7
Show member pathways
11.82 IL2 IL2RB IL4
8
Show member pathways
11.6 IL2 IL2RB IL4
9 11.5 IL2 IL4
10
Show member pathways
11.44 IL2 IL4
11 11.4 IL2 IL2RB IL4
12
Show member pathways
11.33 IL2 IL2RB
13
Show member pathways
11.26 IL2 IL2RB IL4
14
Show member pathways
11.1 IL2 IL2RB
15 11 IL2 IL2RB IL4
16 10.99 CD68 IL2 IL2RB IL4
17 10.95 IL2 IL4
18 10.85 IL2 IL4
19 10.65 IL2 IL2RB IL4

GO Terms for Virus Associated Hemophagocytic Syndrome

Biological processes related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.63 IL2 IL2RB IL4
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 IL2 IL4
3 positive regulation of T cell proliferation GO:0042102 9.4 IL2 IL4
4 positive regulation of B cell proliferation GO:0030890 9.37 IL2 IL4
5 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.32 IL2 IL4
6 positive regulation of activated T cell proliferation GO:0042104 9.26 IL2 IL4
7 positive regulation of T cell differentiation GO:0045582 9.16 IL2 IL4
8 positive regulation of isotype switching to IgG isotypes GO:0048304 8.96 IL2 IL4
9 negative regulation of T-helper 17 cell differentiation GO:2000320 8.62 IL2 IL4

Sources for Virus Associated Hemophagocytic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
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48 NDF-RT
51 NINDS
52 Novoseek
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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