MCID: VRS001
MIFTS: 36

Virus Associated Hemophagocytic Syndrome

Categories: Rare diseases

Aliases & Classifications for Virus Associated Hemophagocytic Syndrome

MalaCards integrated aliases for Virus Associated Hemophagocytic Syndrome:

Name: Virus Associated Hemophagocytic Syndrome 49

Classifications:



Summaries for Virus Associated Hemophagocytic Syndrome

NIH Rare Diseases : 49 Virus associated hemophagocytic syndromeis a very serious complication of a viral infection. Signs and symptoms of virus associated hemophagocytic syndrome, include high fever, liver problems, enlarged liver and spleen, coagulation factor abnormalities, decreased red or white blood cells and platelets (pancytopenia), and a build-up of histiocytes, a type of immune cell, in various tissues in the body resulting in the destruction of blood-producing cells (histiocytic proliferation with prominent hemophagocytosis). Diagnosis is based upon the signs and symptoms of the patient. The cause of the condition is not known. Treatment is challenging and approach will vary depending on the age and medical history of the patient. Complications of this syndrome can become life threatening. Related conditions (conditions with overlapping signs and symptoms), include histiocytic medullary reticulosis (HMR), familial hemophagocytic lymphohistiocytosis (FHL), and X-linked lymphoproliferative syndrome. Last updated: 5/8/2013

MalaCards based summary : Virus Associated Hemophagocytic Syndrome is related to metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration and hemophagocytic syndrome associated with an infection. An important gene associated with Virus Associated Hemophagocytic Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are IL-2 Pathway and Pathways in cancer. The drugs Etoposide and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone marrow, and related phenotype is hematopoietic system.

Related Diseases for Virus Associated Hemophagocytic Syndrome

Diseases related to Virus Associated Hemophagocytic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 29.8 MB PIK3C2A
2 hemophagocytic syndrome associated with an infection 11.6
3 bone fracture 10.3 IL2 MB
4 atopic keratoconjunctivitis 10.2 IL2 IL4
5 jak3-deficient severe combined immunodeficiency 10.2 IL2 IL4
6 angiostrongyliasis 10.2 IL2 IL4
7 microscopic colitis 10.2 IL2 IL4
8 vulvovaginal candidiasis 10.2 IL2 IL4
9 coccidiosis 10.2 IL2 IL4
10 severe combined immunodeficiency, x-linked 10.2 IL2 IL4
11 acute graft versus host disease 10.2 IL2 IL4
12 onchocerciasis 10.2 IL2 IL4
13 b-cell expansion with nfkb and t-cell anergy 10.2 IL2 IL2RB
14 paracoccidioidomycosis 10.2 IL2 IL4
15 vernal conjunctivitis 10.2 IL2 IL4
16 brucellosis 10.2 IL2 IL4
17 leukocyte disease 10.2 IL2 IL4
18 histiocytosis 10.2
19 malignant histiocytosis 10.2
20 leprosy 3 10.2 IL2 IL4
21 tonsillitis 10.2 IL2 IL4
22 spondyloarthropathy 10.2 IL2 IL4
23 parasitic protozoa infectious disease 10.2 IL2 IL4
24 conjunctivitis 10.2 IL2 IL4
25 keratoconjunctivitis 10.2 IL2 IL4
26 primary bacterial infectious disease 10.1 IL2 IL4
27 interstitial myocarditis 10.1 MB PIK3C2A
28 bone inflammation disease 10.1 IL2 IL4
29 creatine phosphokinase, elevated serum 10.1 MB PIK3C2A
30 sezary's disease 10.1 IL2 IL4
31 toxic shock syndrome 10.1 IL2 IL4
32 posterior myocardial infarction 10.1 MB PIK3C2A
33 myositis fibrosa 10.1 MB PIK3C2A
34 hypersensitivity reaction disease 10.1 IL2 IL4
35 anuria 10.1 MB PIK3C2A
36 plexopathy 10.1 MB PIK3C2A
37 neuroleptic malignant syndrome 10.1 MB PIK3C2A
38 schistosomiasis 10.1 IL2 IL4
39 compartment syndrome 10.1 MB PIK3C2A
40 intermediate coronary syndrome 10.1 MB PIK3C2A
41 acute mountain sickness 10.1 MB PIK3C2A
42 polymyositis 10.1 MB PIK3C2A
43 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 MB PIK3C2A
44 combined immunodeficiency, x-linked 10.1 IL2 IL4
45 myoglobinuria 10.1 MB PIK3C2A
46 trichinosis 10.1 IL4 PIK3C2A
47 trypanosomiasis 10.1 IL2 IL4
48 acute kidney failure 10.1 MB PIK3C2A
49 immune system disease 10.1 IL2 IL4
50 cutaneous t cell lymphoma 10.1 IL2 IL4

Graphical network of the top 20 diseases related to Virus Associated Hemophagocytic Syndrome:



Diseases related to Virus Associated Hemophagocytic Syndrome

Symptoms & Phenotypes for Virus Associated Hemophagocytic Syndrome

MGI Mouse Phenotypes related to Virus Associated Hemophagocytic Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 IL2RB IL4 MB PIK3C2A CD68 IL2

Drugs & Therapeutics for Virus Associated Hemophagocytic Syndrome

Drugs for Virus Associated Hemophagocytic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved 33419-42-0 36462
2
Methotrexate Approved 1959-05-2, 59-05-2 126941
3
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
4
Busulfan Approved, Investigational 55-98-1 2478
5
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
6
Lenograstim Approved, Investigational 135968-09-1
7
Prednisolone Approved, Vet_approved 50-24-8 5755
8
Methylprednisolone Approved, Vet_approved 83-43-2 6741
9
Prednisone Approved, Vet_approved 53-03-2 5865
10
leucovorin Approved, Nutraceutical 58-05-9 143 6006
11
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
12 Alkylating Agents
13 Folic Acid Antagonists
14 Topoisomerase Inhibitors
15 Cyclosporins
16 Nucleic Acid Synthesis Inhibitors
17 Dermatologic Agents
18 Vitamin B Complex
19 Anti-Infective Agents
20 Antifungal Agents
21 Etoposide phosphate
22 Antilymphocyte Serum
23 Immunosuppressive Agents
24 Antimetabolites
25 Antimetabolites, Antineoplastic
26 Antineoplastic Agents, Phytogenic
27 Antirheumatic Agents
28 Calcineurin Inhibitors
29 Prednisolone acetate
30 glucocorticoids
31 Methylprednisolone acetate
32 Methylprednisolone Hemisuccinate
33 Gastrointestinal Agents
34 Neuroprotective Agents
35 Complement System Proteins
36 Hormone Antagonists
37 Hormones
38 Hormones, Hormone Substitutes, and Hormone Antagonists
39 Peripheral Nervous System Agents
40 Antiemetics
41 Prednisolone hemisuccinate
42 Prednisolone phosphate
43 Anti-Inflammatory Agents
44 Protective Agents
45 Antineoplastic Agents, Hormonal
46 Autonomic Agents
47 Folate Nutraceutical
48 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders Unknown status NCT00006056 anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;filgrastim;methotrexate
2 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054 anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;methotrexate;methylprednisolone;prednisone

Search NIH Clinical Center for Virus Associated Hemophagocytic Syndrome

Genetic Tests for Virus Associated Hemophagocytic Syndrome

Anatomical Context for Virus Associated Hemophagocytic Syndrome

MalaCards organs/tissues related to Virus Associated Hemophagocytic Syndrome:

38
Liver, Spleen, Bone Marrow, Bone, T Cells

Publications for Virus Associated Hemophagocytic Syndrome

Articles related to Virus Associated Hemophagocytic Syndrome:

(show top 50) (show all 91)
# Title Authors Year
1
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection. ( 27883370 )
2016
2
Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. ( 27496079 )
2016
3
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome. ( 25941132 )
2015
4
Virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. ( 25838952 )
2015
5
P488. Virus associated hemophagocytic syndrome: rare but serious complication of azathioprine treatment in patients with CrohnA' s disease. ( 25717983 )
2015
6
BK virus-associated hemophagocytic syndrome in a renal transplant recipient. ( 24821160 )
2014
7
Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome. ( 23991898 )
2013
8
Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient. ( 22185972 )
2012
9
Ocular findings in a patient with virus-associated hemophagocytic syndrome. ( 22486263 )
2012
10
A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome. ( 22286408 )
2012
11
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. ( 21366922 )
2011
12
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. ( 21628863 )
2011
13
Dengue virus associated hemophagocytic syndrome in children: a case report. ( 20853575 )
2010
14
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. ( 20348529 )
2010
15
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. ( 19640781 )
2009
16
Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. ( 19571453 )
2009
17
Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. ( 19795003 )
2009
18
Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis. ( 19561991 )
2008
19
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. ( 17893313 )
2007
20
Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. ( 17456768 )
2007
21
Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. ( 17703994 )
2007
22
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). ( 17106167 )
2006
23
Late-onset fatal Epstein-Barr virus-associated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia. ( 17189228 )
2006
24
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis. ( 15625619 )
2005
25
Cyclosporin neurotoxicity with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15753052 )
2005
26
Mumps virus-associated hemophagocytic syndrome. ( 15759337 )
2005
27
Epstein-Barr virus-associated hemophagocytic syndrome as first presentation of Fanconi anemia. ( 15926162 )
2005
28
Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. ( 15754587 )
2005
29
Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS. ( 15897649 )
2005
30
Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15465418 )
2004
31
Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a non-compromised host; a case report of unusual entity. ( 15086189 )
2004
32
Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12767005 )
2003
33
Unusual clinical manifestation of virus-associated hemophagocytic syndrome. ( 14708643 )
2003
34
Sequential quantification of Epstein-Barr virus DNA in a case of Epstein-Barr virus-associated hemophagocytic syndrome. ( 12416743 )
2002
35
Viral load in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12363023 )
2002
36
Epstein-Barr virus-associated hemophagocytic syndrome masquerading as lymphoma: a case report. ( 11456362 )
2001
37
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. ( 11475151 )
2001
38
No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan. ( 11536244 )
2001
39
CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. ( 10954276 )
2000
40
Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection. ( 10367794 )
1999
41
Clinicopathological findings of virus-associated hemophagocytic syndrome in bone marrow: association with Epstein-Barr virus and apoptosis. ( 10469396 )
1999
42
Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia. ( 9880630 )
1998
43
Virus-associated hemophagocytic syndrome after hepatic resection: a case report. ( 9496516 )
1998
44
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. ( 9766697 )
1998
45
Therapy-related AML after successful chemotherapy with low dose etoposide for virus-associated hemophagocytic syndrome. ( 9846019 )
1998
46
Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome. ( 9444599 )
1997
47
Epstein-Barr virus induced virus-associated hemophagocytic syndrome and monoclonal TCR-beta rearrangement: a case report. ( 9378473 )
1997
48
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. ( 9498706 )
1997
49
Epstein Barr virus associated hemophagocytic syndrome--a case report. ( 9364304 )
1997
50
Epstein-Barr virus--Associated hemophagocytic syndrome. A cause of fever of unknown origin in human immunodeficiency virus infection. ( 9278614 )
1997

Variations for Virus Associated Hemophagocytic Syndrome

Expression for Virus Associated Hemophagocytic Syndrome

Search GEO for disease gene expression data for Virus Associated Hemophagocytic Syndrome.

Pathways for Virus Associated Hemophagocytic Syndrome

Pathways related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 IL2 IL2RB IL4 PIK3C2A
2 12.49 IL2 IL2RB IL4
3
Show member pathways
12.44 IL2 IL2RB IL4
4
Show member pathways
12.41 IL2 IL2RB IL4
5
Show member pathways
12.24 IL2 IL2RB IL4
6 12.2 IL2 IL2RB IL4
7
Show member pathways
12.01 IL2 IL2RB PIK3C2A
8
Show member pathways
11.96 IL2 IL2RB IL4
9
Show member pathways
11.6 IL2 IL2RB IL4
10 11.5 IL2 IL4
11
Show member pathways
11.45 IL2 IL4
12 11.4 IL2 IL2RB IL4
13
Show member pathways
11.33 IL2 IL2RB
14
Show member pathways
11.26 IL2 IL2RB IL4
15
Show member pathways
11.05 IL2 IL2RB
16 10.99 IL2 IL2RB IL4
17 10.99 CD68 IL2 IL2RB IL4
18 10.95 IL2 IL4
19 10.85 IL2 IL4
20 10.65 IL2 IL2RB IL4

GO Terms for Virus Associated Hemophagocytic Syndrome

Biological processes related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.5 IL2 IL2RB IL4
2 positive regulation of T cell proliferation GO:0042102 9.26 IL2 IL4
3 positive regulation of B cell proliferation GO:0030890 9.16 IL2 IL4
4 positive regulation of T cell differentiation GO:0045582 8.96 IL2 IL4
5 positive regulation of isotype switching to IgG isotypes GO:0048304 8.62 IL2 IL4

Sources for Virus Associated Hemophagocytic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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