MCID: VRS001
MIFTS: 35

Virus Associated Hemophagocytic Syndrome malady

Categories: Rare diseases

Aliases & Classifications for Virus Associated Hemophagocytic Syndrome

Aliases & Descriptions for Virus Associated Hemophagocytic Syndrome:

Name: Virus Associated Hemophagocytic Syndrome 50

Classifications:



Summaries for Virus Associated Hemophagocytic Syndrome

NIH Rare Diseases : 50 virus associated hemophagocytic syndrome is a very serious complication of a viral infection. signs and symptoms of virus associated hemophagocytic syndrome, include high fever, liver problems, enlarged liver and spleen, coagulation factor abnormalities, decreased red or white blood cells and platelets (pancytopenia), and a build-up of histiocytes, a type of immune cell, in various tissues in the body resulting in the destruction of blood-producing cells (histiocytic proliferation with prominent hemophagocytosis). diagnosis is based upon the signs and symptoms of the patient. the cause of the condition is not known. treatment is challenging and approach will vary depending on the age and medical history of the patient. complications of this syndrome can become life threatening. related conditions (conditions with overlapping signs and symptoms), include histiocytic medullary reticulosis (hmr), familial hemophagocytic lymphohistiocytosis (fhl), and x-linked lymphoproliferative syndrome. last updated: 5/8/2013

MalaCards based summary : Virus Associated Hemophagocytic Syndrome is related to sarcoma and tuberculosis. An important gene associated with Virus Associated Hemophagocytic Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are IL-2 Pathway and Influenza A. The drugs Etoposide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone marrow, and related phenotypes are hematopoietic system and immune system

Related Diseases for Virus Associated Hemophagocytic Syndrome

Diseases related to Virus Associated Hemophagocytic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Related Disease Score Top Affiliating Genes
1 sarcoma 29.7 IL2 IL4
2 tuberculosis 29.4 IL2 IL4 PIK3C2A
3 autosomal dominant deafness-onychodystrophy syndrome 10.2 IL2 IL4
4 brain ischemia 10.2 IL2 MB
5 thelaziasis 10.2 IL2 IL4
6 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.2 IL2 IL4
7 clostridium difficile colitis 10.2 IL2 IL4
8 gonadal disease 10.2 IL2 IL4
9 opitz-kaveggia syndrome 10.2 IL2 IL4
10 tularemia 10.2 IL2 IL4
11 central nervous system origin vertigo 10.1 IL2 IL4
12 acute myeloid leukemia with recurrent genetic anomaly 10.1 IL2 IL4
13 abnormal retinal correspondence 10.1 IL2 IL4
14 inflamed seborrheic keratosis 10.1 IL2 IL4
15 lung combined large cell neuroendocrine carcinoma 10.1 IL2 IL4
16 orbital osteomyelitis 10.1 IL2 IL4
17 myiasis 10.1 IL2 IL4
18 histiocytosis 10.1
19 malignant histiocytosis 10.1
20 hyperaldosteronism, familial, type ii 10.1 IL2 IL2RB
21 myopathy, distal, tateyama type 10.1 MB PIK3C2A
22 papillary pattern testicular yolk sac tumor 10.1 MB PIK3C2A
23 nasopharyngitis 10.1 IL2 IL4
24 actinic keratosis 10.1 IL2 IL4
25 silent myocardial infarction 10.1 MB PIK3C2A
26 eye carcinoma in situ 10.1 IL2 IL4
27 chorea gravidarum 10.1 MB PIK3C2A
28 polyarteritis nodosa 10.1 MB PIK3C2A
29 tracheitis 10.1 IL2 IL4
30 infiltrating ureter transitional cell carcinoma 10.1 MB PIK3C2A
31 thyroid hyalinizing trabecular adenoma 10.1 IL2 IL4
32 anal colloid adenocarcinoma 10.1 MB PIK3C2A
33 dengue hemorrhagic fever 10.1 IL2 IL4
34 acute dacryoadenitis 10.1 IL2 IL4
35 microphthalmia, isolated, with coloboma 7 10.1 MB PIK3C2A
36 liver inflammatory pseudotumor 10.1 IL2 IL4
37 acute posterior multifocal placoid pigment epitheliopathy 10.1 MB PIK3C2A
38 posterior uveitis 10.1 CD68 IL2
39 acute lymphoblastic leukemia, childhood 10.1 MB PIK3C2A
40 blue toe syndrome 10.1 IL2 IL4
41 nonspecific interstitial pneumonia 10.0 IL2 IL4
42 glaucoma iridogoniodysgenesia 10.0 CD68 MB
43 choriocarcinoma of ovary 10.0 CD68 MB
44 intracranial liposarcoma 10.0 CD68 MB
45 endodermal sinus tumor 10.0 CD68 MB
46 multiple carboxylase deficiency 10.0 IL2 IL4
47 intraorbital meningioma 10.0 CD68 MB
48 alkhurma hemorrhagic fever 10.0 CD68 IL4
49 cutaneous ganglioneuroma 10.0 CD68 IL4
50 uterus interstitial leiomyoma 10.0 IL2 IL4

Graphical network of the top 20 diseases related to Virus Associated Hemophagocytic Syndrome:



Diseases related to Virus Associated Hemophagocytic Syndrome

Symptoms & Phenotypes for Virus Associated Hemophagocytic Syndrome

MGI Mouse Phenotypes related to Virus Associated Hemophagocytic Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD68 IL2 IL2RB IL4 MB PIK3C2A
2 immune system MP:0005387 9.02 CD68 IL2 IL2RB IL4 PIK3C2A

Drugs & Therapeutics for Virus Associated Hemophagocytic Syndrome

Drugs for Virus Associated Hemophagocytic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Asparaginase Approved Phase 3 9015-68-3
7
Pegaspargase Approved, Investigational Phase 3 130167-69-0
8
Doxil Approved June 1999 Phase 3 31703
9 Topoisomerase Inhibitors Phase 3
10 Etoposide phosphate Phase 3
11 Antineoplastic Agents, Phytogenic Phase 3
12 Prednisolone acetate Phase 3
13 Dexamethasone acetate Phase 3 1177-87-3
14 glucocorticoids Phase 3
15
protease inhibitors Phase 3
16 Gastrointestinal Agents Phase 3
17 Neuroprotective Agents Phase 3
18 HIV Protease Inhibitors Phase 3
19 Hormone Antagonists Phase 3
20 Dexamethasone 21-phosphate Phase 3
21 Hormones Phase 3
22 Peripheral Nervous System Agents Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
24 Anti-Bacterial Agents Phase 3
25 Prednisolone hemisuccinate Phase 3
26 Prednisolone phosphate Phase 3
27 Protective Agents Phase 3
28 Antiemetics Phase 3
29 Anti-Inflammatory Agents Phase 3
30 Antibiotics, Antitubercular Phase 3
31 Methylprednisolone acetate Phase 3
32 Methylprednisolone Hemisuccinate Phase 3
33 BB 1101 Phase 3
34 Autonomic Agents Phase 3
35 Antineoplastic Agents, Hormonal Phase 3
36
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
37
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
38
alemtuzumab Approved, Investigational Phase 2 216503-57-0
39 Alkylating Agents Phase 2
40 Anti-Infective Agents Phase 2
41 Immunosuppressive Agents Phase 2
42 Antimetabolites Phase 2
43 Antimetabolites, Antineoplastic Phase 2
44 Antirheumatic Agents Phase 2
45 Antineoplastic Agents, Alkylating Phase 2
46 Antiviral Agents Phase 2
47
Cyclosporine Approved, Investigational, Vet_approved 79217-60-0, 59865-13-3 5284373 6435893
48
Methotrexate Approved 1959-05-2, 59-05-2 126941
49
Busulfan Approved, Investigational 55-98-1 2478
50
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189

Interventional clinical trials:


id Name Status NCT ID Phase
1 L-DEP as an Initial Treatment for EBV-HLH Recruiting NCT02912702 Phase 3
2 T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts Recruiting NCT00368355 Phase 2
3 CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene Active, not recruiting NCT00710892 Phase 1
4 Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders Unknown status NCT00006056
5 Transfusion-related EBV Infection Among Allogeneic Stem Cell Transplant Pediatric Recipients Recruiting NCT02505789
6 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054

Search NIH Clinical Center for Virus Associated Hemophagocytic Syndrome

Genetic Tests for Virus Associated Hemophagocytic Syndrome

Anatomical Context for Virus Associated Hemophagocytic Syndrome

MalaCards organs/tissues related to Virus Associated Hemophagocytic Syndrome:

39
Liver, Spleen, Bone Marrow, Bone, T Cells

Publications for Virus Associated Hemophagocytic Syndrome

Articles related to Virus Associated Hemophagocytic Syndrome:

(show top 50) (show all 91)
id Title Authors Year
1
Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. ( 27496079 )
2016
2
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection. ( 27883370 )
2016
3
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome. ( 25941132 )
2015
4
Virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. ( 25838952 )
2015
5
P488. Virus associated hemophagocytic syndrome: rare but serious complication of azathioprine treatment in patients with CrohnA' s disease. ( 25717983 )
2015
6
BK virus-associated hemophagocytic syndrome in a renal transplant recipient. ( 24821160 )
2014
7
Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome. ( 23991898 )
2013
8
Ocular findings in a patient with virus-associated hemophagocytic syndrome. ( 22486263 )
2012
9
Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient. ( 22185972 )
2012
10
A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome. ( 22286408 )
2012
11
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. ( 21366922 )
2011
12
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. ( 21628863 )
2011
13
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. ( 20348529 )
2010
14
Dengue virus associated hemophagocytic syndrome in children: a case report. ( 20853575 )
2010
15
Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. ( 19571453 )
2009
16
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. ( 19640781 )
2009
17
Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. ( 19795003 )
2009
18
Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis. ( 19561991 )
2008
19
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. ( 17893313 )
2007
20
Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. ( 17456768 )
2007
21
Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. ( 17703994 )
2007
22
Late-onset fatal Epstein-Barr virus-associated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia. ( 17189228 )
2006
23
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). ( 17106167 )
2006
24
Epstein-Barr virus-associated hemophagocytic syndrome as first presentation of Fanconi anemia. ( 15926162 )
2005
25
Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. ( 15754587 )
2005
26
Mumps virus-associated hemophagocytic syndrome. ( 15759337 )
2005
27
Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS. ( 15897649 )
2005
28
Cyclosporin neurotoxicity with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15753052 )
2005
29
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis. ( 15625619 )
2005
30
Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15465418 )
2004
31
Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a non-compromised host; a case report of unusual entity. ( 15086189 )
2004
32
Unusual clinical manifestation of virus-associated hemophagocytic syndrome. ( 14708643 )
2003
33
Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12767005 )
2003
34
Viral load in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12363023 )
2002
35
Sequential quantification of Epstein-Barr virus DNA in a case of Epstein-Barr virus-associated hemophagocytic syndrome. ( 12416743 )
2002
36
Epstein-Barr virus-associated hemophagocytic syndrome masquerading as lymphoma: a case report. ( 11456362 )
2001
37
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. ( 11475151 )
2001
38
No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan. ( 11536244 )
2001
39
CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. ( 10954276 )
2000
40
Clinicopathological findings of virus-associated hemophagocytic syndrome in bone marrow: association with Epstein-Barr virus and apoptosis. ( 10469396 )
1999
41
Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection. ( 10367794 )
1999
42
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. ( 9766697 )
1998
43
Virus-associated hemophagocytic syndrome after hepatic resection: a case report. ( 9496516 )
1998
44
Therapy-related AML after successful chemotherapy with low dose etoposide for virus-associated hemophagocytic syndrome. ( 9846019 )
1998
45
Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia. ( 9880630 )
1998
46
Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome. ( 9444599 )
1997
47
Epstein Barr virus associated hemophagocytic syndrome--a case report. ( 9364304 )
1997
48
Epstein-Barr virus--Associated hemophagocytic syndrome. A cause of fever of unknown origin in human immunodeficiency virus infection. ( 9278614 )
1997
49
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. ( 9498706 )
1997
50
Epstein-Barr virus induced virus-associated hemophagocytic syndrome and monoclonal TCR-beta rearrangement: a case report. ( 9378473 )
1997

Variations for Virus Associated Hemophagocytic Syndrome

Expression for Virus Associated Hemophagocytic Syndrome

Search GEO for disease gene expression data for Virus Associated Hemophagocytic Syndrome.

Pathways for Virus Associated Hemophagocytic Syndrome

Pathways related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 IL2 IL2RB IL4 PIK3C2A
2
Show member pathways
12.46 IL2 IL2RB IL4
3
Show member pathways
12.45 IL2 IL2RB IL4
4
Show member pathways
12.26 IL2 IL2RB IL4
5 12.25 IL2 IL2RB IL4
6 12.18 IL2 IL2RB IL4
7
Show member pathways
12.01 IL2 IL2RB PIK3C2A
8
Show member pathways
11.82 IL2 IL2RB IL4
9
Show member pathways
11.6 IL2 IL2RB IL4
10 11.51 IL2 IL4
11
Show member pathways
11.46 IL2 IL4
12 11.4 IL2 IL2RB IL4
13 11.39 IL2 IL2RB
14
Show member pathways
11.34 IL2 IL2RB
15
Show member pathways
11.26 IL2 IL2RB IL4
16
Show member pathways
11.1 IL2 IL2RB
17 11 IL2 IL2RB IL4
18 10.99 CD68 IL2 IL2RB IL4
19 10.95 IL2 IL4
20
Show member pathways
10.93 IL2 IL2RB
21 10.85 IL2 IL4
22 10.65 IL2 IL2RB IL4

GO Terms for Virus Associated Hemophagocytic Syndrome

Biological processes related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.65 IL2 IL2RB IL4
2 positive regulation of T cell proliferation GO:0042102 9.46 IL2 IL4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 IL2 IL4
4 positive regulation of B cell proliferation GO:0030890 9.4 IL2 IL4
5 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.37 IL2 IL4
6 positive regulation of activated T cell proliferation GO:0042104 9.32 IL2 IL4
7 positive regulation of T cell differentiation GO:0045582 9.26 IL2 IL4
8 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.16 IL2 IL4
9 positive regulation of isotype switching to IgG isotypes GO:0048304 8.96 IL2 IL4
10 negative regulation of T-helper 17 cell differentiation GO:2000320 8.62 IL2 IL4

Sources for Virus Associated Hemophagocytic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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