MCID: VSC003
MIFTS: 58

Visceral Leishmaniasis malady

Infectious category

Summaries for Visceral Leishmaniasis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

MalaCards: Visceral Leishmaniasis, also known as leishmaniasis visceral, is related to cutaneous leishmaniasis and arthritis. An important gene associated with Visceral Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Th17 Differentiation and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs meglumine and pentamidine and the compounds rantes and betaseron have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. the symptoms include fever, weight loss, and an enlarged spleen and liver.

Wikipedia:64 Visceral leishmaniasis (VL), also known as kala-azar, black fever, and Dumdum fever, is the most severe... more...

Aliases & Classifications for Visceral Leishmaniasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

visceral leishmaniasis 8 10
leishmaniasis visceral 8 45
infection by visceral leishmaniasis 8
infection by leishmania donovani 8
leishmaniasis, visceral 61
kala-azar 8


External Ids:

Disease Ontology8 DOID:9146
MeSH35 D007898
NCIt40 C34771
SNOMED-CT57 186803007, 48115004
ICD9CM27 085.0
ICD1025 B55, B55.0, B55.9

Related Diseases for Visceral Leishmaniasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the leishmaniasis family:

visceral leishmaniasis

Diseases related to Visceral Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous leishmaniasis31.1IFNG, IL10
2arthritis30.7IFNG, CXCL9, IL10, IL4, SLC11A1
3tuberculosis30.4IFNG, CXCL9, IL10, IL4, SLC11A1
4hepatitis c30.4IL4, IL10, IFNG
5lepromatous leprosy30.3IFNG, IL10, IL4
6uveitis30.3IL4, IL10, CXCL9, IFNG
7tuberculoid leprosy30.3IL10, IFNG
8hepatitis b30.1IFNG
9systemic lupus erythematosus30.1IFNG, IL10RA, IL10, IL21, IL4
10hemophagocytic lymphohistiocytosis10.5
11splenomegaly10.5
12kala-azar 110.5
13pancytopenia10.5
14immune-complex glomerulonephritis10.4
15kala-azar 310.4
16chagas disease10.3
17autoimmune hepatitis10.3
18hepatitis a10.3
19chronic granulomatous disease10.3
20hepatitis e10.3
21acquired immunodeficiency syndrome10.3
22malignant histiocytosis10.3
23paronychia10.2
24indeterminate leprosy10.2
25strongyloidiasis10.2
26mucocutaneous leishmaniasis10.2
27felty's syndrome10.2
28leptospirosis10.2
29borderline leprosy10.2
30tropical sprue10.2
31syphilis10.2
32toxoplasmosis10.2
33anterior uveitis10.2
34macroglossia10.2
35leukopenia10.2
36acute liver failure10.1
37acalculous cholecystitis10.1
38acute pancreatitis10.1
39cryoglobulinemia10.1
40evans' syndrome10.1
41sleeping sickness10.1
42crimean-congo hemorrhagic fever10.1
43mixed connective tissue disease10.1
44primary biliary cirrhosis10.1
45stevens-johnson syndrome10.1
46common variable immunodeficiency10.1
47psoriatic arthritis10.1
48polyarteritis nodosa10.1
49polyclonal hypergammaglobulinemia10.1
50japanese encephalitis10.1

Graphical network of the top 20 diseases related to Visceral Leishmaniasis:



Diseases related to visceral leishmaniasis

Clinical Features for Visceral Leishmaniasis

Drugs & Therapeutics for Visceral Leishmaniasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Visceral Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Visceral Leishmaniasis

Search NIH Clinical Center for Visceral Leishmaniasis

Search CenterWatch for Visceral Leishmaniasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Visceral Leishmaniasis

Anatomical Context for Visceral Leishmaniasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Visceral Leishmaniasis:

33
Skin, Liver, Brain, Kidney, Lymph node, Spleen, Bone marrow, Whole blood, Smooth muscle, Pancreas, Monocytes, T cells, B lymphoblasts, B cells

Animal Models for Visceral Leishmaniasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Visceral Leishmaniasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.2UQCRFS1, VDAC3, DLL1, IL10RA, IL10, IL21
2MP:000538710.1SLC11A1, CCL1, IFNG, GNB1L, DLL1, CXCL9
3MP:000539710.0IFNG, GNB1L, DLL1, IL10RA, IL10, IL21

Publications for Visceral Leishmaniasis

Sources:
51PubMed
See all sources

Articles related to Visceral Leishmaniasis:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Mannose-conjugated chitosan nanoparticles loaded with rifampicin for the treatment of visceral leishmaniasis. (24299880)
2014
2
Visceral leishmaniasis with associated immune dysregulation leading to lymphoma. (23707131)
2013
3
Involvement and interactions of different immune cells and their cytokines in human visceral leishmaniasis. (23559342)
2013
4
Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis. (22886470)
2013
5
Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis. (24167266)
2013
6
Is the IL-10 -819 polymorphism associated with visceral leishmaniasis? (23912644)
2013
7
Development of novel prime-boost strategies based on a tri-gene fusion recombinant L. tarentolae vaccine against experimental murine visceral leishmaniasis. (23638195)
2013
8
Electrospray encapsulation of toll-like receptor agonist resiquimod in polymer microparticles for the treatment of visceral leishmaniasis. (23320733)
2013
9
Evaluation of rK-39 strip test using urine for diagnosis of visceral leishmaniasis in an endemic region of India. (23149580)
2013
10
Comparative analysis of serum zinc, copper, magnesium, calcium and iron level in acute and chronic patients of visceral leishmaniasis. (23199594)
2013
11
Naturally Leishmania infantum-infected dogs display an overall impairment of chemokine and chemokine receptor expression during visceral leishmaniasis. (23545087)
2013
12
Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison. (23658850)
2013
13
Canine visceral leishmaniasis and Chagas disease among dogs in AraguaA-na, Tocantins. (23802237)
2013
14
Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. (23556019)
2013
15
Relapsing visceral leishmaniasis in a HIV-1 infected patient with advanced disease. (23967722)
2013
16
Studies on the protective and immunomodulatory efficacy of Withania somnifera along with cisplatin against experimental visceral leishmaniasis. (23519426)
2013
17
Larval breeding sites of Lutzomyia longipalpis (Diptera: Psychodidae) in visceral leishmaniasis endemic urban areas in Southeastern Brazil. (24069494)
2013
18
Molecular diagnosis of canine visceral leishmaniasis: a comparative study of three methods using skin and spleen from dogs with natural Leishmania infantum infection. (23953760)
2013
19
Canine visceral leishmaniasis: diagnostic approaches based on polymerase chain reaction employing different biological samples. (23619344)
2013
20
Visceral leishmaniasis with associated common, uncommon, and atypical morphological features on bone marrow aspirate cytology in nonendemic region. (24089618)
2013
21
Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005. (23563826)
2013
22
Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis. (23288063)
2012
23
Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis. (22323556)
2012
24
Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives. (22698479)
2012
25
Visceral Leishmaniasis Eradication is a Reality: Data from a Community-based Active Surveillance in Bangladesh. (23532674)
2012
26
Visceral leishmaniasis diagnosed by double balloon enteroscopy. (22738708)
2012
27
Post-kala-azar dermal leishmaniasis in visceral leishmaniasis-endemic communities in Bihar, India. (22882665)
2012
28
Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) in the region of Saquarema: potential area of visceral leishmaniasis transmission in the state of Rio de Janeiro, Brazil. (22370841)
2012
29
Sand fly vectors (Diptera, Psychodidae) of American visceral leishmaniasis areas in the Atlantic Forest, State of EspA-rito Santo, southeastern Brazil. (22548541)
2012
30
Treatment of visceral leishmaniasis: model-based analyses on the spread of antimony-resistant L. donovani in Bihar, India. (23285309)
2012
31
Autochthonous disseminated dermal and visceral leishmaniasis in an AIDS patient, southern Thailand, caused by Leishmania siamensis. (22556080)
2012
32
Endemic transmission of visceral leishmaniasis in Bhutan. (23091191)
2012
33
Identification and diagnostic utility of Leishmania infantum proteins found in urine samples from patients with visceral leishmaniasis. (22518013)
2012
34
Immunity to visceral leishmaniasis. (22253634)
2012
35
Role of leptin in human visceral leishmaniasis? (21724337)
2011
36
Serological markers of sand fly exposure to evaluate insecticidal nets against visceral leishmaniasis in India and Nepal: a cluster-randomized trial. (21931871)
2011
37
High concentration of adenosine in human visceral leishmaniasis despite increased ADA and decreased CD73. (21729107)
2011
38
Visceral leishmaniasis in children: a cohort of 120 patients in a metropolitan city of Brazil. (21853652)
2011
39
Molecular Analysis of A2-genes Encoding Stage-specific S Antigen-like Proteins among Isolates from Iranian Cutaneous and Visceral Leishmaniasis. (23493637)
2011
40
Visceral leishmaniasis in a patient with cutaneous lesions, negative Leishman-Donovan bodies and immunological test: A case report. (22973355)
2011
41
Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis. (19592661)
2009
42
Protein-energy malnutrition as a risk factor for visceral leishmaniasis: a review. (19751470)
2009
43
Genes and environment in susceptibility to visceral leishmaniasis. (17067929)
2006
44
Proteomic approach for characterization of immunodominant membrane-associated 30- to 36-kiloDalton fraction antigens of Leishmania infantum promastigotes, reacting with sera from Mediterranean visceral leishmaniasis patients. (15699427)
2005
45
Immunity and immunosuppression in experimental visceral leishmaniasis. (15064826)
2004
46
Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis. (9952391)
1999
47
Circulating T helper 1 (Th1) cell- and Th2 cell-associated cytokines in Indian patients with visceral leishmaniasis. (9180602)
1997
48
In vivo and in vitro cytokine profiles and mononuclear cell subsets in Sicilian patients with active visceral leishmaniasis. (8580385)
1995
49
Visceral leishmaniasis in patients with AIDS: report of three cases treated with pentavalent antimony and interferon-gamma. (8353246)
1993
50
The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients. (1424277)
1992

Genetic Variations for Visceral Leishmaniasis

Expression for genes affiliated with Visceral Leishmaniasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Visceral Leishmaniasis

Search GEO for disease gene expression data for Visceral Leishmaniasis.

Pathways for genes affiliated with Visceral Leishmaniasis

Sources:
53R&D Systems, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5IL21
210.4IL4, IL21
310.4IFNG, IL10, IL4
410.4IL4, IL10, IFNG
5
Hide members
10.4IL27, IL10, IFNG
610.4IL4, CSN2, IFNG
7
Development PDGF signaling via STATs and NF-kB
Hide members
10.4IFNG, CXCL9, IL10RA, IL10
8
Hide members
10.4HSPA1L, HSPA2, IFNG, IL4
9
Hide members
10.4CCL16, CCL1, GNB1L, IL10RA
1010.4IFNG, IL10RA, IL10, IL21, IL4
1110.4HSPA1L, HSPA2, IFNG, IL10RA, IL10
12
Hide members
10.4IFNG, VDAC3, CXCL9, IL10
13
Hide members
10.3HSPA1L, HSPA2, IFNG, IL10RA, IL10, IL4
14
Hide members
10.3IL4, IL10, IL10RA, IFNG, CCL1, CCL16
15
Hide members
10.3IL4, HSPA1L, HSPA2, IFNG, IL10RA, IL10
16
Hide members
10.3CCL16, CCL1, DLL1, CXCL9, IL10RA, IL21
17
Hide members
10.3CCL16, CCL1, CXCL9, IL10RA, IL10, IL21
18
Hide members
10.3CCL16, CCL1, IFNG, CXCL9, IL10RA, IL10

Compounds for genes affiliated with Visceral Leishmaniasis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1rantes4510.8IL4, IFNG, CCL16
2betaseron4510.8IL4, IL10, IFNG
3interferon gamma4510.8IL4, IL10, IFNG
4alpha-galactosylceramide4510.8IFNG, IL10, IL4
5monomethyl fumarate4510.7IL10, IL4
6con a4510.7IFNG, IL10, IL21, IL4
7glatiramer acetate45 1111.7IFNG, IL10, IL4
8il-124510.7IL4, IL10, IFNG
9gm-csf45 2911.7IL10, IFNG
10il 104510.7IFNG, CXCL9, IL10RA, IL10, IL4
11polymyxin b4510.7IL4, IL10, IFNG
12allergens4510.7IL4, IL10, CSN2, IFNG
13tarc4510.7CCL1, IFNG, CXCL9, IL10, IL4
14okt34510.7IFNG, IL10, IL4
15ccl345 2911.7CCL16, CCL1, IFNG, CXCL9, IL10
16polyinosinic-polycytidylic acid4510.7IFNG, IL10, IL4
17infliximab45 50 1112.7IFNG, IL10, IL4
18ribavirin45 50 1112.7IL4, IL10, IFNG
19ionomycin4510.6IL4, IL10, CXCL9, IFNG
20ivig4510.6IFNG, IL10, IL4
21pentoxifylline45 1111.6IFNG, IL10, IL4
22quinine45 29 2 1113.6IL4, IL10, CXCL9
23acidophilus4510.6IL4, IL10
24ifn-alpha4510.5IFNG, CXCL9, IL10
25neopterin4510.5IL4, IL10, IFNG
26tuberculin4510.4IL10, IFNG
2715-deoxy-delta-12,14-prostaglandin j24510.4IFNG, IL10, IL4
28histamine45 29 2412.3IL4, IL10, CXCL9, IFNG
29mip 1alpha4510.1IL4, IL10

GO Terms for genes affiliated with Visceral Leishmaniasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.2IL4, IL27, IL21, IL10, CXCL9, IFNG

Biological processes related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.7IL4, IL10, IFNG
2defense response to protozoanGO:04283210.7SLC11A1, IL4, IFNG
3regulation of isotype switchingGO:04519110.7IL4, IL10
4type 2 immune responseGO:04209210.7IL4, IL10
5positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
6positive regulation of T cell proliferationGO:04210210.7IL4, IL21, IFNG
7chemotaxisGO:00693510.7CCL16, CCL1, CXCL9, IL4
8positive regulation of chemokine biosynthetic processGO:04508010.7IL4, IFNG
9positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.6IL21, IFNG
10inflammatory responseGO:00695410.6CCL16, CXCL9, IL10, IL27, SLC11A1
11immune responseGO:00695510.6CCL16, CCL1, CXCL9, IL21, IL4
12negative regulation of nitric oxide biosynthetic processGO:04501910.6IL4, IL10
13cell-cell signalingGO:00726710.5CCL16, DLL1, CXCL9, IL10
14positive regulation of interferon-gamma biosynthetic processGO:04507810.5IL27, IL21
15response to drugGO:04249310.5IFNG, UQCRFS1, IL10, IL4
16response to bacteriumGO:00961710.4SLC11A1, IL27
17defense response to bacteriumGO:04274210.4IFNG, IL10, SLC11A1
18negative regulation of growth of symbiont in hostGO:04413010.3IL10, IFNG
19positive regulation of interleukin-10 productionGO:03273310.1IL4, IL21

Molecular functions related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.4CXCL9, CCL1, CCL16
2cytokine activityGO:00512510.0IL4, IL27, IL21, IL10, CXCL9, IFNG

Products for genes affiliated with Visceral Leishmaniasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Visceral Leishmaniasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet