MCID: VSC003
MIFTS: 61

Visceral Leishmaniasis malady

Infectious diseases category

Summaries for Visceral Leishmaniasis

About this section
Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

MalaCards: Visceral Leishmaniasis, also known as leishmaniasis visceral, is related to leishmaniasis and cutaneous leishmaniasis. An important gene associated with Visceral Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Th17 Differentiation and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs meglumine and pentamidine and the compounds rantes and betaseron have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and liver, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. the symptoms include fever, weight loss, and an enlarged spleen and liver.

Wikipedia:63 Visceral leishmaniasis (VL), also known as kala-azar, black fever, and Dumdum fever, is the most severe... more...

Aliases & Classifications for Visceral Leishmaniasis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

visceral leishmaniasis 8 10
leishmaniasis visceral 8 44
infection by visceral leishmaniasis 8
infection by leishmania donovani 8
leishmaniasis, visceral 60
kala-azar 8


External Ids:

Disease Ontology8 DOID:9146
MeSH34 D007898
NCIt39 C34771
SNOMED-CT56 186803007, 48115004
ICD9CM27 085.0
ICD1025 B55, B55.0, B55.9

Related Diseases for Visceral Leishmaniasis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Visceral Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis32.2SLC11A1, IFNG, IL10, IL4, LMLN
2cutaneous leishmaniasis31.0IFNG, IL10
3leprosy30.8SLC11A1
4arthritis30.7IFNG, CXCL9, IL10, IL4, SLC11A1
5malaria30.5IFNG, CXCL9, IL10, SLC11A1
6rheumatoid arthritis30.5IFNG, CXCL9, IL10RA, IL10, IL21, IL4
7leukemia30.3IFNG, DLL1, IL4
8tuberculosis30.3IFNG, CXCL9, IL10, IL4, SLC11A1
9lepromatous leprosy30.3IFNG, IL10, IL4
10uveitis30.3IL4, IL10, CXCL9, IFNG
11tuberculoid leprosy30.3IL10, IFNG
12hepatitis b30.1IFNG
13sarcoidosis30.1IFNG, CXCL9, SLC11A1
14encephalitis30.1CXCL9
15myeloma30.1IL4
16systemic lupus erythematosus30.1IFNG, IL10RA, IL10, IL21, IL4
17psoriasis30.1IFNG, CXCL9, IL10RA, IL10, IL4
18lymphopenia30.1IL4, IL10, IFNG
19pancreatitis30.1IL10
20hemophagocytic lymphohistiocytosis10.5
21pancytopenia10.4
22hepatitis10.4
23immune-complex glomerulonephritis10.4
24kala-azar 210.4
25kala-azar 310.4
26kala-azar 110.4
27chagas disease10.3
28autoimmune hepatitis10.3
29chronic granulomatous disease10.2
30acquired immunodeficiency syndrome10.2
31malignant histiocytosis10.2
32cervicitis10.2
33connective tissue disease10.2
34histiocytosis10.2
35paronychia10.2
36indeterminate leprosy10.2
37strongyloidiasis10.2
38mucocutaneous leishmaniasis10.2
39felty's syndrome10.2
40leptospirosis10.2
41borderline leprosy10.2
42disseminated intravascular coagulation10.2
43relapsing fever10.2
44syphilis10.2
45toxoplasmosis10.2
46acute liver failure10.1
47acalculous cholecystitis10.1
48acute pancreatitis10.1
49cryoglobulinemia10.1
50evans' syndrome10.1

Graphical network of the top 20 diseases related to Visceral Leishmaniasis:



Diseases related to visceral leishmaniasis

Clinical Features for Visceral Leishmaniasis

About this section

Drugs & Therapeutics for Visceral Leishmaniasis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Visceral Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Visceral Leishmaniasis

Search NIH Clinical Center for Visceral Leishmaniasis

Search CenterWatch for Visceral Leishmaniasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Visceral Leishmaniasis

About this section

Anatomical Context for Visceral Leishmaniasis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Visceral Leishmaniasis:

32
Bone marrow, Bone, Liver, Spleen, Testes, Skin, T cells, Kidney, Monocytes, Whole blood, B cells, Smooth muscle, Pancreas, Brain, Lymph node

Animal Models for Visceral Leishmaniasis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Visceral Leishmaniasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.2UQCRFS1, VDAC3, DLL1, IL10RA, IL10, IL21
2MP:000538710.1SLC11A1, CCL1, IFNG, GNB1L, DLL1, CXCL9
3MP:000539710.0IFNG, GNB1L, DLL1, IL10RA, IL10, IL21

Publications for Visceral Leishmaniasis

About this section
Sources:
50PubMed
See all sources

Articles related to Visceral Leishmaniasis:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Liposomal amphotericin B for complicated visceral leishmaniasis (kala-azar) in eastern Sudan: how effective is treatment for this neglected disease? (24433217)
2014
2
Role of fine-needle aspiration cytology in the prompt diagnosis of recurrence of visceral leishmaniasis presented as isolated cervical leishmanial lymphadenopathy. (21671412)
2013
3
Canine visceral leishmaniasis: a comparative study of real-time PCR, conventional PCR, and direct agglutination on sera for the detection of Leishmania infantum infection. (23153824)
2013
4
Cellular immunophenotypic profile in the splenic compartment during canine visceral leishmaniasis. (24365402)
2013
5
Comparative study of microscopy and polymerase chain reaction for the diagnosis of suspected visceral leishmaniasis patients in Nepal. (23774406)
2013
6
N New Insights into the Diagnosis and Chemotheraphy for Visceral Leishmaniasis. (24033264)
2013
7
Autoimmune manifestations in patients with visceral leishmaniasis. (22516744)
2013
8
UDP-galactopyranose mutases from Leishmania species that cause visceral and cutaneous leishmaniasis. (24012809)
2013
9
First autochthonous case of canine visceral leishmaniasis in Volta Redonda, Rio de Janeiro, Brazil. (24142177)
2013
10
The IL-33/ST2 axis is associated with human visceral leishmaniasis and suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania donovani. (24045639)
2013
11
Visceral leishmaniasis prevalence and associated risk factors in the saran district of Bihar, India, from 2009 to July of 2011. (23382167)
2013
12
Antigenicity and protective efficacy of a Leishmania amastigote-specific protein, member of the super-oxygenase family, against visceral leishmaniasis. (23573301)
2013
13
First comparative transcriptomic analysis of wild adult male and female Lutzomyia longipalpis, vector of visceral leishmaniasis. (23554910)
2013
14
Hepatosplenic gamma delta T-cell lymphoma in a boy with visceral leishmaniasis: a case report. (24330681)
2013
15
High levels of soluble CD40 ligand and matrix metalloproteinase-9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis. (23870715)
2013
16
Validation of two rapid diagnostic tests for visceral leishmaniasis in Kenya. (24086782)
2013
17
Transmission of visceral leishmaniasis in a previously non-endemic region of Tunisia: detection of Leishmania DNA in Phlebotomus perniciosus. (23701601)
2013
18
Acute liver failure: a rare clinical presentation of visceral leishmaniasis. (22378560)
2012
19
Immunity to visceral leishmaniasis using genetically defined live-attenuated parasites. (21912560)
2012
20
Lysis syndrome during therapy of visceral leishmaniasis. (22005934)
2012
21
Evaluating the potential of polyester nanoparticles for per oral delivery of amphotericin B in treating visceral leishmaniasis. (22852479)
2012
22
Evaluation of serum procalcitonin levels for diagnosis of secondary bacterial infections in visceral leishmaniasis patients. (22232461)
2012
23
Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis. (22704924)
2012
24
Visceral leishmaniasis infection in a refractory multiple myeloma patient treated with bortezomib. (22584850)
2012
25
Heterogeneity of environments associated with transmission of visceral leishmaniasis in South-Eastern France and implication for control strategies. (22880142)
2012
26
Performance of rK39 immunochromatography and freeze-dried direct agglutination tests in the diagnosis of imported visceral leishmaniasis. (21710347)
2012
27
Leishmania donovani triose phosphate isomerase: a potential vaccine target against visceral leishmaniasis. (23049855)
2012
28
A global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. (22942208)
2012
29
Uncoupling protein 2 negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. (21705615)
2011
30
Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent? (21980542)
2011
31
KSAC, the first defined polyprotein vaccine candidate for visceral leishmaniasis. (21632891)
2011
32
Rare association of Visceral leishmaniasis with Hodgkin's disease: A case report. (22011565)
2011
33
Toolkit for monitoring and evaluation of indoor residual spraying for visceral leishmaniasis control in the Indian subcontinent: application and results. (21811510)
2011
34
Metagenomic analysis of taxa associated with Lutzomyia longipalpis, vector of visceral leishmaniasis, using an unbiased high-throughput approach. (21909446)
2011
35
Mannosylated liposomes bearing Amphotericin B for effective management of visceral Leishmaniasis. (21612342)
2011
36
Survey of domestic cattle for anti-Leishmania antibodies and Leishmania DNA in a visceral leishmaniasis endemic area of Bangladesh. (21651757)
2011
37
CD 28 gene polymorphism and plasma concentration of soluble CD 28 in Iranian patients with visceral leishmaniasis. (20962715)
2010
38
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis. (19578629)
2009
39
Visceral leishmaniasis infection in a patient with rheumatoid arthritis treated with etanercept. (16865310)
2007
40
A rare presentation of visceral leishmaniasis without fever or splenomegaly in an elderly person. (17338973)
2007
41
Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis. (15569785)
2004
42
Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells. (12803856)
2003
43
Cellular profile of cytokine production in a patient with visceral leishmaniasis: gammadelta+ T cells express both type 1 cytokines and interleukin-10. (12641659)
2003
44
Possible role of the 34-kilodalton hyaluronic acid-binding protein in visceral Leishmaniasis. (10461949)
1999
45
High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis. (9472662)
1998
46
Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis. (8207220)
1994
47
Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. (8004810)
1994
48
Mononuclear cell subpopulations and cytokine levels in human visceral leishmaniasis before and after chemotherapy. (8376845)
1993
49
Visceral leishmaniasis with a very-low degree of bone-marrow parasitemia, mimicking malignant histiocytosis. (21573388)
1993
50
Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. (2104665)
1990

Genetic Variations for Visceral Leishmaniasis

About this section

Expression for genes affiliated with Visceral Leishmaniasis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Visceral Leishmaniasis

Search GEO for disease gene expression data for Visceral Leishmaniasis.

Pathways for genes affiliated with Visceral Leishmaniasis

About this section
Sources:
52R&D Systems, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5IL21
210.4IL4, IL21
310.4IFNG, IL10, IL4
410.4IL4, IL10, IFNG
5
Hide members
10.4IL27, IL10, IFNG
610.4IL4, CSN2, IFNG
7
Development PDGF signaling via STATs and NF-kB
Hide members
10.4IFNG, CXCL9, IL10RA, IL10
8
Hide members
10.4HSPA1L, HSPA2, IFNG, IL4
9
Hide members
10.4CCL16, CCL1, GNB1L, IL10RA
1010.4IFNG, IL10RA, IL10, IL21, IL4
1110.4HSPA1L, HSPA2, IFNG, IL10RA, IL10
12
Hide members
10.4IFNG, VDAC3, CXCL9, IL10
13
Hide members
10.3HSPA1L, HSPA2, IFNG, IL10RA, IL10, IL4
14
Hide members
10.3IL4, IL10, IL10RA, IFNG, CCL1, CCL16
15
Hide members
10.3IL4, HSPA1L, HSPA2, IFNG, IL10RA, IL10
16
Hide members
10.3CCL16, CCL1, DLL1, CXCL9, IL10RA, IL21
17
Hide members
10.3CCL16, CCL1, CXCL9, IL10RA, IL10, IL21
18
Hide members
10.3CCL16, CCL1, IFNG, CXCL9, IL10RA, IL10

Compounds for genes affiliated with Visceral Leishmaniasis

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1rantes4410.8IL4, IFNG, CCL16
2betaseron4410.8IL4, IL10, IFNG
3interferon gamma4410.8IL4, IL10, IFNG
4alpha-galactosylceramide4410.8IFNG, IL10, IL4
5monomethyl fumarate4410.7IL10, IL4
6con a4410.7IFNG, IL10, IL21, IL4
7glatiramer acetate44 1111.7IFNG, IL10, IL4
8il-124410.7IL4, IL10, IFNG
9gm-csf44 2811.7IL10, IFNG
10il 104410.7IFNG, CXCL9, IL10RA, IL10, IL4
11polymyxin b4410.7IL4, IL10, IFNG
12allergens4410.7IL4, IL10, CSN2, IFNG
13tarc4410.7CCL1, IFNG, CXCL9, IL10, IL4
14okt34410.7IFNG, IL10, IL4
15ccl344 2811.7CCL16, CCL1, IFNG, CXCL9, IL10
16polyinosinic-polycytidylic acid4410.7IFNG, IL10, IL4
17infliximab44 49 1112.7IFNG, IL10, IL4
18ribavirin44 49 1112.7IL4, IL10, IFNG
19ionomycin4410.6IL4, IL10, CXCL9, IFNG
20ivig4410.6IFNG, IL10, IL4
21pentoxifylline44 1111.6IFNG, IL10, IL4
22quinine44 28 2 1113.6IL4, IL10, CXCL9
23acidophilus4410.6IL4, IL10
24ifn-alpha4410.5IFNG, CXCL9, IL10
25neopterin4410.5IL4, IL10, IFNG
26tuberculin4410.4IL10, IFNG
2715-deoxy-delta-12,14-prostaglandin j24410.4IFNG, IL10, IL4
28histamine44 28 2412.3IL4, IL10, CXCL9, IFNG
29mip 1alpha4410.1IL4, IL10

GO Terms for genes affiliated with Visceral Leishmaniasis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.2IL4, IL27, IL21, IL10, CXCL9, IFNG

Biological processes related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.7IL4, IL10, IFNG
2defense response to protozoanGO:04283210.7SLC11A1, IL4, IFNG
3regulation of isotype switchingGO:04519110.7IL4, IL10
4type 2 immune responseGO:04209210.7IL4, IL10
5positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
6positive regulation of T cell proliferationGO:04210210.7IL4, IL21, IFNG
7chemotaxisGO:00693510.7CCL16, CCL1, CXCL9, IL4
8positive regulation of chemokine biosynthetic processGO:04508010.7IL4, IFNG
9positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.6IL21, IFNG
10inflammatory responseGO:00695410.6CCL16, CXCL9, IL10, IL27, SLC11A1
11immune responseGO:00695510.6CCL16, CCL1, CXCL9, IL21, IL4
12negative regulation of nitric oxide biosynthetic processGO:04501910.6IL4, IL10
13cell-cell signalingGO:00726710.5CCL16, DLL1, CXCL9, IL10
14positive regulation of interferon-gamma biosynthetic processGO:04507810.5IL27, IL21
15response to drugGO:04249310.5IFNG, UQCRFS1, IL10, IL4
16response to bacteriumGO:00961710.4SLC11A1, IL27
17defense response to bacteriumGO:04274210.4IFNG, IL10, SLC11A1
18negative regulation of growth of symbiont in hostGO:04413010.3IL10, IFNG
19positive regulation of interleukin-10 productionGO:03273310.1IL4, IL21

Molecular functions related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.4CXCL9, CCL1, CCL16
2cytokine activityGO:00512510.0IL4, IL27, IL21, IL10, CXCL9, IFNG

Products for genes affiliated with Visceral Leishmaniasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Visceral Leishmaniasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet