MCID: VSC003
MIFTS: 59

Visceral Leishmaniasis malady

Infectious diseases category
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Summaries for Visceral Leishmaniasis

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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CDC:4 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

MalaCards: Visceral Leishmaniasis, also known as leishmaniasis visceral, is related to leishmaniasis and leprosy. An important gene associated with Visceral Leishmaniasis is SLC11A1 (solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1), and among its related pathways are African trypanosomiasis and Cytokines and Inflammatory Response. The drugs meglumine and pentamidine and the compounds betaseron and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and liver, and related mouse phenotypes are digestive/alimentary and normal.

Disease Ontology:8 A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. the symptoms include fever, weight loss, and an enlarged spleen and liver.

Wikipedia:65 Visceral leishmaniasis (VL), also known as kala-azar, black fever, and Dumdum fever, is the most severe... more...

Aliases & Classifications for Visceral Leishmaniasis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 35MeSH, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

visceral leishmaniasis 8 10
leishmaniasis visceral 8 45
infection by visceral leishmaniasis 8
infection by leishmania donovani 8
leishmaniasis, visceral 62
kala-azar 8


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Disease Ontology8 DOID:9146
NCIt40 C34771
MeSH35 D007898
SNOMED-CT58 186803007, 48115004
ICD9CM27 085.0
ICD1025 B55, B55.0, B55.9

Related Diseases for Visceral Leishmaniasis

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17GeneCards, 18GeneDecks
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Diseases related to Visceral Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis32.3IL10, SLC11A1, IFNG
2leprosy31.1SLC11A1
3cutaneous leishmaniasis30.8IFNG, IL10
4arthritis30.7SLC11A1, IL10, IFNG, CXCR1
5malaria30.6IFNG, SLC11A1, IL10
6tuberculoid leprosy30.5IL10, IFNG
7lepromatous leprosy30.5IL10, IFNG
8uveitis30.4IFNG, CXCR1, IL10
9rheumatoid arthritis30.4SLC11A1, IL10RA, IL10, IFNG, CXCR1, IL21
10tuberculosis30.4IFNG, SLC11A1, CXCR1, IL10
11lymphopenia30.2IL10, IFNG
12sarcoidosis30.2SLC11A1, IFNG
13psoriasis30.1IL10, CXCR1, IFNG, IL10RA
14systemic lupus erythematosus30.0IL10RA, IL10, IFNG, IL21
15hemophagocytic lymphohistiocytosis10.5
16splenomegaly10.5
17pancytopenia10.5
18hiv-110.5
19hepatitis10.4
20immune-complex glomerulonephritis10.4
21kala-azar 210.4
22kala-azar 310.4
23kala-azar 110.4
24autoimmune hepatitis10.4
25chagas disease10.4
26acquired immunodeficiency syndrome10.3
27malignant histiocytosis10.3
28chronic granulomatous disease10.3
29cervicitis10.3
30connective tissue disease10.3
31histiocytosis10.3
32leukemia10.3
33hiv/aids10.3
34strongyloidiasis10.3
35leptospirosis10.3
36indeterminate leprosy10.3
37mucocutaneous leishmaniasis10.3
38felty's syndrome10.3
39paronychia10.3
40disseminated intravascular coagulation10.3
41relapsing fever10.3
42syphilis10.3
43toxoplasmosis10.3
44anterior uveitis10.3
45macroglossia10.3
46leukopenia10.3
47acute liver failure10.1
48evans' syndrome10.1
49cryoglobulinemia10.1
50acute pancreatitis10.1

Graphical network of the top 20 diseases related to Visceral Leishmaniasis:



Diseases related to visceral leishmaniasis

Symptoms for Visceral Leishmaniasis

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Drugs & Therapeutics for Visceral Leishmaniasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Visceral Leishmaniasis

Search NIH Clinical Center for Visceral Leishmaniasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Visceral Leishmaniasis

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Anatomical Context for Visceral Leishmaniasis

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33MalaCards
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MalaCards organs/tissues related to Visceral Leishmaniasis:

33
Bone marrow, Bone, Liver, Spleen, Testes, Skin, T cells, Kidney, Monocytes, Whole blood, B cells, Smooth muscle, Pancreas, Brain, Lymph node

Animal Models for Visceral Leishmaniasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Visceral Leishmaniasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5SLC11A1, DLL1, IL10RA, IL10, IFNG
2MP:00028737.9DLL1, IL10, IL21, IFNG, CXCR1
3MP:00053977.8IFNG, IL21, IL10, IL10RA, DLL1, SLC11A1
4MP:00053877.6IFNG, IL21, IL10, IL10RA, DLL1, SLC11A1

Publications for Visceral Leishmaniasis

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52PubMed
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Articles related to Visceral Leishmaniasis:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Five-Year Field Results and Long-Term Effectiveness of 20 mg/kg Liposomal Amphotericin B (Ambisome) for Visceral Leishmaniasis in Bihar, India. (24392168)
2014
2
Experimental infection of dogs with Leishmania and saliva as a model to study Canine Visceral Leishmaniasis. (23577121)
2013
3
Role of fine-needle aspiration cytology in the prompt diagnosis of recurrence of visceral leishmaniasis presented as isolated cervical leishmanial lymphadenopathy. (21671412)
2013
4
Association of interleukin-18 gene variants with susceptibility to visceral leishmaniasis in Iranian population. (23269628)
2013
5
Validation of a direct agglutination test prototype kit for the diagnosis of visceral leishmaniasis. (23382276)
2013
6
Diagnosis of visceral leishmaniasis in Bihar India: comparison of the rK39 rapid diagnostic test on whole blood versus serum. (23717700)
2013
7
Visceral leishmaniasis with associated immune dysregulation leading to lymphoma. (23707131)
2013
8
Identification of environmental parameters and risk mapping of visceral leishmaniasis in Ethiopia by using geographical information systems and a statistical approach. (23733292)
2013
9
Adherence to miltefosine treatment for visceral leishmaniasis under routine conditions in Nepal. (23199340)
2013
10
Cationic solid-lipid nanoparticles are as efficient as electroporation in DNA vaccination against visceral leishmaniasis in mice. (23710803)
2013
11
A series of case reports of autochthonous visceral leishmaniasis, mostly in non-endemic hilly areas of Nepal. (23249686)
2013
12
Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis. (23288063)
2012
13
Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis. (22323556)
2012
14
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
15
Comparative study of rK39 Leishmania antigen for serodiagnosis of visceral leishmaniasis: systematic review with meta-analysis. (22303488)
2012
16
Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis. (23147810)
2012
17
Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors. (23151408)
2012
18
Asymptomatic carriage of Leishmania in family members of patients with visceral leishmaniasis in Central Tunisia. (22154335)
2012
19
The economic value of a visceral leishmaniasis vaccine in Bihar state, India. (22403311)
2012
20
Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives. (22698479)
2012
21
Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum. (22840335)
2012
22
Leishmania chagasi naturally resistant to nitric oxide isolated from humans and dogs with visceral leishmaniasis in Brazil. (22580230)
2012
23
Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis. (22860118)
2012
24
Insecticide susceptibility status of Phlebotomus argentipes, a vector of visceral leishmaniasis in different foci in three states of India. (23428526)
2012
25
Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent. (22753945)
2012
26
Burden of visceral leishmaniasis in villages of eastern Gedaref State, Sudan: an exhaustive cross-sectional survey. (23133683)
2012
27
Visceral Leishmaniasis Eradication is a Reality: Data from a Community-based Active Surveillance in Bangladesh. (23532674)
2012
28
Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use. (22573856)
2012
29
Reassessment of immune correlates in human visceral leishmaniasis as defined by cytokine release in whole blood. (22539471)
2012
30
Ecological aspects of phlebotomines (Diptera: Psychodidae) in endemic area of visceral leishmaniasis, Campo Grande, State of Mato Grosso do Sul, Brazil. (22308770)
2012
31
In vitro antileishmanial drug susceptibility of clinical isolates from patients with Indian visceral leishmaniasis--status of newly introduced drugs. (22927497)
2012
32
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. (21357266)
2011
33
Case report: Acute renal injury as a result of liposomal amphotericin B treatment in sodium stibogluconate unresponsive visceral leishmaniasis. (22144439)
2011
34
Role of leptin in human visceral leishmaniasis? (21724337)
2011
35
Uncoupling protein 2 negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. (21705615)
2011
36
Will visceral leishmaniasis be eliminated from Nepal? A review of recent (1994-2006) control efforts. (22808821)
2011
37
Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent? (21980542)
2011
38
Clinical expression of autoimmune hepatitis in a nine-year-old girl with visceral leishmaniasis. (21866471)
2011
39
Canine visceral leishmaniasis: study of methods for the detection of IgG in serum and eluate samples. (21748226)
2010
40
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
41
CD 28 gene polymorphism and plasma concentration of soluble CD 28 in Iranian patients with visceral leishmaniasis. (20962715)
2010
42
Anti-iL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide. (19634715)
2009
43
Cerebrospinal fluid involvement in a case of visceral leishmaniasis associated with hemophagocytic lymphohistiocytosis. (21748112)
2007
44
The epidemiology of visceral leishmaniasis and asymptomatic leishmanial infection in a highly endemic Bangladeshi village. (17488915)
2007
45
Adenosine deaminase activity in sera of patients with visceral leishmaniasis in Nepal. (15970028)
2005
46
Oxidative stress and non-enzymatic antioxidative status in dogs with visceral Leishmaniasis. (15120954)
2004
47
Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis. (15569785)
2004
48
Splenomegaly in Baringo District, Kenya, an area endemic for visceral leishmaniasis and malaria. (7483000)
1995
49
Diffuse nodular regenerative hyperplasia of the liver associated with human immunodeficiency virus and visceral leishmaniasis. (8438854)
1993
50
Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. (2104665)
1990

Variations for Visceral Leishmaniasis

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Expression for genes affiliated with Visceral Leishmaniasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Visceral Leishmaniasis

Search GEO for disease gene expression data for Visceral Leishmaniasis.

Pathways for genes affiliated with Visceral Leishmaniasis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 60Thomson Reuters
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Pathways related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL10, IFNG
29.7IL10, IFNG
3
Show member pathways
IL27-mediated signaling events38
9.7IL10, IFNG
4
Show member pathways
9.7IL10, IFNG
59.7IFNG, IL10
69.7IFNG, IL10
79.7IFNG, IL10
89.5IL10RA, IL10
9
Show member pathways
9.5IL21, IFNG
10
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.2IL10RA, IL10, IFNG
119.2IL10RA, IL10, IFNG
128.7IL10RA, IL10, IFNG, HSPA1L
13
Show member pathways
8.7HSPA1L, IFNG, IL10, IL10RA
14
Show member pathways
8.6IL21, IL10, IL10RA, DLL1
15
Show member pathways
Type III interferon signaling38
8.5IFNG, IL21, IL10, IL10RA
16
Show member pathways
8.1IL10RA, IL10, IL21, IFNG, HSPA1L
17
Show member pathways
7.7CXCR1, IFNG, IL21, IL10, IL10RA

Compounds for genes affiliated with Visceral Leishmaniasis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1betaseron4510.1IL10, IFNG
2interferon gamma4510.1IL10, IFNG
3alpha-galactosylceramide4510.1IFNG, IL10
4glatiramer acetate45 1111.1IL10, IFNG
5tuberculin4510.1IL10, IFNG
6natalizumab45 1111.1IFNG, IL10
7il-124510.1IL10, IFNG
8adalimumab45 51 1112.0IL10, IFNG
9indoleamine4510.0IFNG, IL10
10imiquimod45 61 29 1113.0IL10, IFNG
11polymyxin b4510.0IFNG, IL10
12citrulline45 2411.0IL10, IFNG
13okt34510.0IFNG, IL10
14gm-csf45 2911.0IL10, IFNG
152,5-oligoadenylate4510.0IFNG, IL10
16polyinosinic-polycytidylic acid4510.0IFNG, IL10
17rolipram45 61 2912.0IL10, IFNG
18etanercept45 51 1111.9IL10, IFNG
19mycophenolate mofetil45 51 1111.9IL10, IFNG
20infliximab45 51 1111.9IFNG, IL10
21ivig459.9IL10, IFNG
22ribavirin45 51 1111.9IL10, IFNG
23pentoxifylline45 1110.8IFNG, IL10
24ifn-alpha459.8IL10, IFNG
25neopterin459.8IFNG, IL10
2615-deoxy-delta-12,14-prostaglandin j2459.7IL10, IFNG
27thalidomide45 51 61 1112.7IL10, IFNG
28allergens459.6IL10, IFNG
29il 10459.6IL10RA, IL10, IFNG
30groalpha459.6CXCR1, IL10
31con a459.5IL10, IL21, IFNG
32tarc459.3CXCR1, IFNG, IL10
33ccl345 2910.3IL10, IFNG, CXCR1
34endotoxin459.3IL10, IFNG, CXCR1
35rantes458.7CXCR1, IFNG, IL21, IL10
36cycloheximide458.6CXCR1, IFNG, IL10

GO Terms for genes affiliated with Visceral Leishmaniasis

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16Gene Ontology
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Biological processes related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.9IL10, IFNG
2defense response to protozoanGO:0428329.9SLC11A1, IFNG
3negative regulation of growth of symbiont in hostGO:0441309.9IL10, IFNG
4protein import into nucleus, translocationGO:0000609.8SLC11A1, IFNG
5cellular response to lipopolysaccharideGO:0712229.7IL10, IFNG
6positive regulation of tyrosine phosphorylation of Stat1 proteinGO:0425119.7IFNG, IL21
7defense response to bacteriumGO:0427429.6SLC11A1, IL10, IFNG
8hemopoiesisGO:0300979.4DLL1, IL10
9positive regulation of T cell proliferationGO:0421029.4IL21, IFNG
10positive regulation of transcription from RNA polymerase II promoterGO:0459449.1IFNG, IL10, DLL1, SLC11A1
11inflammatory responseGO:0069548.9CXCR1, IL10, SLC11A1

Molecular functions related to Visceral Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, IL21, IFNG

Products for genes affiliated with Visceral Leishmaniasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Visceral Leishmaniasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet