Visceral Steatosis malady

MalaCards: Visceral Steatosis, also known as fatty metamorphosis of viscera, is related to carnitine deficiency and sudden infant death syndrome. An important gene associated with Visceral Steatosis is SLC22A5 (solute carrier family 22 (organic cation/carnitine transporter), member 5), and among its related pathways are Fatty acid metabolism and Development Leptin signaling via PI3K-dependent pathway. The compounds etomoxir and malonyl-coa have been mentioned in the context of this disorder. Affiliated tissues include heart and liver.

visceral steatosis 30 32 fatty metamorphosis of viscera 30 43 fatal neonatal hepatic steatosis 30

white liver disease 30 steatosis of liver 30

Diseases related to visceral steatosis by text searches and GeneDecks gene sharing:

(show all 13)

id	Related Disease	Score	Top Affiliating Genes
1	carnitine deficiency	27.5	CPT1A, CPT1B, SLC22A5
2	sudden infant death syndrome	12.5	SLC22A5, CPT1A
3	hypoglycemia	12.4	SLC22A5, CPT1A
4	carnitine palmitoyl transferase 1 deficiency	12.4	CPT1A, CPT1B
5	cpt deficiency	12.3	CPT1A, CPT1B
6	pre-eclampsia	12.1	CPT1A, CPT1B
7	chronic myeloid leukemia	12.1	CPT1B, CPT1A
8	eclampsia	12.0	CPT1B, CPT1A
9	myelodysplastic syndrome	12.0	SLC22A5, CPT1A
10	essential hypertension	11.7	CPT1A, CPT1B, SLC22A5
11	hypertension	11.6	CPT1B, CPT1A, SLC22A5
12	azoospermia	6.6
13	fatty liver disease	6.6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to visceral steatosis:

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Articles related to visceral steatosis:

id	Title	Authors	Year	Affiliating Genes
1	Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice. (16734862)	Yakushiji K.... Toshimori K.	2006	SLC22A5
2	A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. (9837751)	Lu K.... Kuwajima M.	1998	SLC22A5
3	Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. (8830050)	Uenaka R.... Ohta S.	1996	CPT1A, CPT1B

Genes related to visceral steatosis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Publications
2	CPT1B	carnitine palmitoyltransferase 1B (muscle)	11.0	Publications
3	CPT1A	carnitine palmitoyltransferase 1A (liver)	11.0	Publications

Pathways related to visceral steatosis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Fatty acid metabolism20	9.2	CPT1B, CPT1A
2	Development Leptin signaling via PI3K-dependent pathway10	9.2	CPT1A, CPT1B
3	Development_Leptin signaling via PI3K-dependent pathway41	9.1	CPT1B, CPT1A
4	AMPK Enzyme Complex Pathway36	9.1	CPT1A, CPT1B
5	Adipocytokine signaling pathway20	9.0	CPT1B, CPT1A
6	PPAR signaling pathway20	8.8	CPT1A, CPT1B

Compounds related to visceral steatosis according to GeneDecks:

(show all 12)

id	Compound	Score	Top Affiliating Genes
1	etomoxir32	9.4	CPT1B, CPT1A
2	malonyl-coa32 18	10.3	CPT1A, CPT1B
3	Coenzyme A9 18 9	11.3	CPT1B, CPT1A
4	acyl-coa32	9.3	CPT1A, CPT1B
5	palmitate32	9.2	CPT1A, CPT1B
6	glycerol32 9 18 9	12.2	CPT1B, CPT1A
7	acetyl-coa32 18	10.1	CPT1B, CPT1A
8	fatty acid32	9.1	CPT1B, CPT1A
9	pyruvate32	9.0	CPT1B, CPT1A
10	glycogen32 18	9.8	CPT1B, CPT1A
11	L-Carnitine9 18 9	10.8	CPT1B, CPT1A, SLC22A5
12	carnitine32	8.7	CPT1B, CPT1A, SLC22A5

Cellular components related to visceral steatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial outer membrane	GO:005741	9.1	CPT1A, CPT1B

Biological processes related to visceral steatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	carnitine shuttle	GO:006853	9.1	CPT1A, CPT1B
2	cellular lipid metabolic process	GO:044255	9.1	CPT1A, CPT1B
3	regulation of fatty acid oxidation	GO:046320	9.0	CPT1A, CPT1B
4	fatty acid beta-oxidation	GO:006635	8.8	CPT1A, CPT1B

Molecular functions related to visceral steatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	carnitine O-palmitoyltransferase activity	GO:004095	9.1	CPT1A, CPT1B