MCID: VSC018
MIFTS: 27

Visceral Steatosis malady

Liver category

Summaries for Visceral Steatosis

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Visceral Steatosis, also known as fatty metamorphosis of viscera, is related to fatty liver disease and azoospermia. An important gene associated with Visceral Steatosis is SLC22A5 (solute carrier family 22 (organic cation/carnitine transporter), member 5), and among its related pathways are PPAR signaling pathway and Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The compounds etomoxir and malonyl-coa have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial.

Aliases & Classifications for Visceral Steatosis

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Aliases & Descriptions:

visceral steatosis 43 45
fatty metamorphosis of viscera 43 61
fatal neonatal hepatic steatosis 43
white liver disease 43
steatosis of liver 43
fatty degeneration 61


Related Diseases for Visceral Steatosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Visceral Steatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease10.1
2azoospermia10.1
3dysferlinopathy10.0
4hypoglycemia10.0CPT1A
5carnitine palmitoyltransferase ii deficiency10.0CPT1A
6sudden infant death syndrome10.0SLC22A5
7carnitine palmitoyl transferase 1 deficiency10.0CPT1A, CPT1B

Graphical network of diseases related to Visceral Steatosis:



Diseases related to visceral steatosis

Clinical Features for Visceral Steatosis

Drugs & Therapeutics for Visceral Steatosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Visceral Steatosis

Drug clinical trials:

Search ClinicalTrials for Visceral Steatosis

Search NIH Clinical Center for Visceral Steatosis

Search CenterWatch for Visceral Steatosis

Genetic Tests for Visceral Steatosis

Anatomical Context for Visceral Steatosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Visceral Steatosis:

33
Heart, Liver, Endothelial, Hypothalamus

Animal Models for Visceral Steatosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Visceral Steatosis

Sources:
51PubMed
See all sources

Articles related to Visceral Steatosis:

(show all 41)
idTitleAuthorsYear
1
Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat. (20111022)
2010
2
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. (20033348)
2010
3
Hepatic steatosis, visceral adiposity, insulin resistance, adiponectin, and inflammation. (19059541)
2009
4
Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus. (19744557)
2009
5
Effect of pronounced weight loss on visceral fat, liver steatosis and adiponectin isoforms. (18312420)
2008
6
Hepatic steatosis rather than visceral adiposity is more closely associated with insulin resistance in the early stage of obesity. (18555841)
2008
7
Visceral adipose tissue area is an independent risk factor for hepatic steatosis. (17995942)
2008
8
The impact of insulin resistance, serum adipocytokines and visceral obesity on steatosis and fibrosis in patients with chronic hepatitis C. (17451564)
2007
9
Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice. (16734862)
2006
10
Attenuation of cardiac hypertrophy in carnitine-deficient juvenile visceral steatosis (JVS) mice achieved by lowering dietary lipid. (16452314)
2006
11
Non-alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in non-diabetic men. Role of visceral adipose tissue. (16176196)
2005
12
Identification of the up- and down-regulated genes in the heart of juvenile visceral steatosis mice. (15056854)
2004
13
Functional disorders of the oxidative phosphorylation system in the heart mitochondria of mice with juvenile visceral steatosis. (12612434)
2003
14
Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice. (11341370)
2001
15
The signaling pathway of cardiotrophin-1 is not activated in hypertrophied ventricles of carnitine-deficient juvenile visceral steatosis (JVS) mice. (10904873)
2000
16
Antagonizing effect of AP-1 on glucocorticoid induction of urea cycle enzymes: a study of hyperammonemia in carnitine-deficient, juvenile visceral steatosis mice. (11136545)
2000
17
Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice. (10100867)
1999
18
Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice. (10087008)
1999
19
Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice. (10498652)
1999
20
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (10025944)
1999
21
Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency. (10210276)
1999
22
Pyruvate dehydrogenase kinase 4 mRNA is increased in the hypertrophied ventricles of carnitine-deficient juvenile visceral steatosis (JVS) mice. (10609898)
1999
23
Characteristics of cardiac hypertrophy in the juvenile visceral steatosis mouse with systemic carnitine deficiency. (9602426)
1998
24
A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. (9837751)
1998
25
Suppressed expression of the urea cycle enzyme genes in the liver of carnitine-deficient juvenile visceral steatosis (JVS) mice in infancy and during starvation in adulthood. (9058209)
1997
26
A novel gene suppressed in the ventricle of carnitine-deficient juvenile visceral steatosis mice. (9187371)
1997
27
Secondary abnormality of carnitine biosynthesis results from carnitine reabsorptional system defect in juvenile visceral steatosis mice. (9540857)
1997
28
Abnormal gene expression causing hyperammonemia in carnitine-deficient juvenile visceral steatosis (JVS) mice. (9286432)
1997
29
The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency. (9212045)
1997
30
Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis. (8605222)
1996
31
Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency. (8858199)
1996
32
Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. (8830050)
1996
33
Carnitine transport defect in fibroblasts of juvenile visceral steatosis (JVS) mouse. (8670273)
1996
34
Mapping of jvs (juvenile visceral steatosis) gene, which causes systemic carnitine deficiency in mice, on chromosome 11. (7626891)
1995
35
Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency. (7773507)
1995
36
Primary defect of juvenile visceral steatosis (jvs) mouse with systemic carnitine deficiency is probably in renal carnitine transport system. (8155735)
1994
37
Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency. (8325377)
1993
38
Abnormal expression of urea cycle enzyme genes in juvenile visceral steatosis (jvs) mice. (1540663)
1992
39
Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver of carnitine-deficient juvenile visceral steatosis (jvs) mice. (1383034)
1992
40
Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription. (1544887)
1992
41
Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis. (1996978)
1991

Genetic Variations for Visceral Steatosis

Expression for genes affiliated with Visceral Steatosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Visceral Steatosis

Search GEO for disease gene expression data for Visceral Steatosis.

Pathways for genes affiliated with Visceral Steatosis

Sources:
30KEGG, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Visceral Steatosis

Sources:
45Novoseek, 24HMDB, 11DrugBank
See all sources

Compounds related to Visceral Steatosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1etomoxir459.4CPT1A, CPT1B
2malonyl-coa45 2410.3CPT1A, CPT1B
3Coenzyme A11 2410.3CPT1A, CPT1B
4acyl-coa459.3CPT1B, CPT1A
5palmitate459.2CPT1B, CPT1A
6glycerol45 11 2411.2CPT1B, CPT1A
7acetyl-coa45 2410.1CPT1A, CPT1B
8fatty acid459.1CPT1B, CPT1A
9pyruvate459.0CPT1B, CPT1A
10glycogen45 249.8CPT1B, CPT1A
11L-Carnitine11 249.8SLC22A5, CPT1B, CPT1A
12carnitine458.7SLC22A5, CPT1B, CPT1A

GO Terms for genes affiliated with Visceral Steatosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Visceral Steatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.1CPT1A, CPT1B

Biological processes related to Visceral Steatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular lipid metabolic processGO:0442559.1CPT1A, CPT1B
2carnitine shuttleGO:0068539.0CPT1A, CPT1B
3fatty acid beta-oxidationGO:0066358.8CPT1A, CPT1B

Molecular functions related to Visceral Steatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carnitine O-palmitoyltransferase activityGO:0040959.1CPT1A, CPT1B

Products for genes affiliated with Visceral Steatosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Visceral Steatosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet