MCID: VSC018
MIFTS: 21

Visceral Steatosis malady

Liver diseases category

Summaries for Visceral Steatosis

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32MalaCards
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MalaCards: Visceral Steatosis, also known as fatty metamorphosis of viscera, is related to fatty liver disease and azoospermia. An important gene associated with Visceral Steatosis is SLC22A5 (solute carrier family 22 (organic cation/carnitine transporter), member 5), and among its related pathways are PPAR signaling pathway and Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The compounds etomoxir and malonyl-coa have been mentioned in the context of this disorder. Affiliated tissues include liver.

Aliases & Classifications for Visceral Steatosis

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Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

visceral steatosis 42 44
fatty metamorphosis of viscera 42 60
fatal neonatal hepatic steatosis 42
white liver disease 42
steatosis of liver 42
fatty degeneration 60


Related Diseases for Visceral Steatosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Visceral Steatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease10.1
2azoospermia10.1
3hypoglycemia10.0CPT1A
4carnitine palmitoyltransferase ii deficiency10.0CPT1A
5sudden infant death syndrome10.0SLC22A5
6hepatitis10.0
7neuropathy10.0
8dysferlinopathy10.0
9carnitine palmitoyl transferase 1 deficiency10.0CPT1A, CPT1B

Graphical network of diseases related to Visceral Steatosis:



Diseases related to visceral steatosis

Clinical Features for Visceral Steatosis

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Drugs & Therapeutics for Visceral Steatosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Visceral Steatosis

Drug clinical trials:

Search ClinicalTrials for Visceral Steatosis

Search NIH Clinical Center for Visceral Steatosis

Search CenterWatch for Visceral Steatosis

Genetic Tests for Visceral Steatosis

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Anatomical Context for Visceral Steatosis

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32MalaCards
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MalaCards organs/tissues related to Visceral Steatosis:

32
Liver

Animal Models for Visceral Steatosis or affiliated genes

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Publications for Visceral Steatosis

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Genetic Variations for Visceral Steatosis

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Expression for genes affiliated with Visceral Steatosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Visceral Steatosis

Search GEO for disease gene expression data for Visceral Steatosis.

Pathways for genes affiliated with Visceral Steatosis

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Sources:
29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Visceral Steatosis

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Sources:
44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Visceral Steatosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1etomoxir449.4CPT1B, CPT1A
2malonyl-coa44 2410.3CPT1A, CPT1B
3Coenzyme A11 2410.3CPT1A, CPT1B
4acyl-coa449.3CPT1B, CPT1A
5palmitate449.2CPT1A, CPT1B
6glycerol44 11 2411.2CPT1A, CPT1B
7acetyl-coa44 2410.1CPT1B, CPT1A
8fatty acid449.1CPT1A, CPT1B
9pyruvate449.0CPT1A, CPT1B
10glycogen44 249.8CPT1A, CPT1B
11L-Carnitine11 249.8CPT1A, CPT1B, SLC22A5
12carnitine448.7CPT1A, CPT1B, SLC22A5

GO Terms for genes affiliated with Visceral Steatosis

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Sources:
16Gene Ontology
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Cellular components related to Visceral Steatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.1CPT1A, CPT1B

Biological processes related to Visceral Steatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular lipid metabolic processGO:0442559.1CPT1A, CPT1B
2carnitine shuttleGO:0068539.0CPT1A, CPT1B
3fatty acid beta-oxidationGO:0066358.8CPT1A, CPT1B

Molecular functions related to Visceral Steatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carnitine O-palmitoyltransferase activityGO:0040959.1CPT1A, CPT1B

Products for genes affiliated with Visceral Steatosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Visceral Steatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet