Aliases & Classifications for Vitamin B12 Deficiency

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 22GTR, 60UMLS
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Vitamin B12 Deficiency, Aliases & Descriptions:

Name: Vitamin B12 Deficiency 9 11 43
Cobalamin Deficiency 9 22
 
Vitamin B 12 Deficiency 60
Hypocobalaminemia 9


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Disease Ontology9 DOID:0050731

Summaries for Vitamin B12 Deficiency

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Disease Ontology:9 A vitamin metabolic disorder that results from low blood levels of vitamin b12.

MalaCards based summary: Vitamin B12 Deficiency, also known as cobalamin deficiency, is related to transcobalamin ii deficiency and megaloblastic anemia. An important gene associated with Vitamin B12 Deficiency is TCN1 (transcobalamin I (vitamin B12 binding protein, R binder family)), and among its related pathways are Vitamin digestion and absorption and Carbon metabolism. The compounds cobinamide and 5-Methyltetrahydrofolic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and breast.

Related Diseases for Vitamin B12 Deficiency

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Graphical network of the top 20 diseases related to Vitamin B12 Deficiency:



Diseases related to vitamin b12 deficiency

Symptoms for Vitamin B12 Deficiency

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Drugs & Therapeutics for Vitamin B12 Deficiency

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Drug clinical trials:

Search ClinicalTrials for Vitamin B12 Deficiency

Search NIH Clinical Center for Vitamin B12 Deficiency

Genetic Tests for Vitamin B12 Deficiency

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Genetic tests related to Vitamin B12 Deficiency:

id Genetic test Affiliating Genes
1 Cobalamin Deficiency22

Anatomical Context for Vitamin B12 Deficiency

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MalaCards organs/tissues related to Vitamin B12 Deficiency:

31
Spinal cord, Bone, Breast, Testes, Brain, Skin, Eye, Heart, Liver, Bone marrow, Smooth muscle, Small intestine, Thyroid, Endothelial, Neutrophil

Animal Models for Vitamin B12 Deficiency or affiliated genes

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Publications for Vitamin B12 Deficiency

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Articles related to Vitamin B12 Deficiency:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Acute demyelination with leukoencephalopathy and cerebellar involvement in vitamin B12 deficiency. (25807133)
2015
2
Acute Myocardial Infarction in a Young Lady due to Vitamin B12 Deficiency Induced Hyperhomocysteinemia. (25838876)
2015
3
Vitamin B12 deficiency in Jordan: a population-based study. (24943588)
2014
4
Vitamin B12 deficiency causing night sweats. (25281396)
2014
5
Undetected vitamin B12 deficiency due to false normal assay results. (23356970)
2013
6
Pancytopenia from severe cobalamin (vitamin B12) deficiency in Johanson-Blizzard syndrome. (23900243)
2013
7
Delirium as a result of vitamin B12 deficiency in a vegetarian female patient. (23859997)
2013
8
Cranial magnetic resonance imaging findings of nutritional vitamin B12 deficiency in 15 hypotonic infants. (21903432)
2012
9
Psychotic disorder, hypertension and seizures associated with vitamin B12 deficiency: a case report. (22027500)
2012
10
Involuntary movements after correction of vitamin B12 deficiency: a video-case report. (22591802)
2012
11
Homocystinuria masquerading as vitamin B12 deficiency. (22864044)
2012
12
Vitamin B12 deficiency causing hyperhomocysteinaemia and cerebral venous sinus thrombosis. (22616971)
2012
13
Re: Honzik T, Adamovicova A, Smolka V, Magner M, Hruba E, Zeman J. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency--what have we learned? Eur Jour Ped Neurol 14 (2010) 488-495. (21295506)
2011
14
Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes. (20890610)
2011
15
Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. (20206879)
2010
16
Charles Bonnet syndrome and vitamin B12 deficiency: a case report. (20633753)
2010
17
"Anchor"-shaped bright posterior column in a patient with vitamin B12 deficiency myelopathy. (19417166)
2009
18
Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. (18214631)
2008
19
Serum vitamin B12 deficiency and hyperhomocystinemia: a reversible cause of acute chorea, cerebellar ataxia in an adult with cerebral ischemia. (18678379)
2008
20
Effects of maternal vitamin B12 deficiency from end of gestation to weaning on the growth and haematological and immunological parameters in mouse dams and offspring. (18459540)
2008
21
Vitamin B12 deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver. (17761010)
2008
22
Neurologic disease and vitamin B12 deficiency. (17920997)
2007
23
High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. (16601915)
2006
24
Patient and family fact sheet. Vitamin B12 deficiency and the nervous system. (16688019)
2006
25
Primary SjAPgren's syndrome and vitamin B12 deficiency: preliminary results in 80 patients. (16750953)
2006
26
Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes. (15805657)
2005
27
Prevalence of vitamin B12 deficiency in patients with plasma cell dyscrasias. (15937914)
2005
28
Use of metformin is a cause of vitamin B12 deficiency. (14765765)
2004
29
Predictors of vitamin B12 deficiency: age and Helicobacter pylori load of antral mucosa. (14593537)
2003
30
Vitamin B12 deficiency. (12643357)
2003
31
Cobalamin (vitamin B12)-deficiency-induced changes in the proteome of rat cerebrospinal fluid. (12769818)
2003
32
Iron and vitamin B12 deficiency anaemia in a vegetarian. (12572200)
2002
33
Vitamin B12 deficiency among elderly patients an important diagnosis. (15112856)
2002
34
Serum acylcarnitines and vitamin B12 deficiency. (12089192)
2002
35
Reversible chorea and focal dystonia in vitamin B12 deficiency. (12140313)
2002
36
Metformin and vitamin B12 deficiency. (11863489)
2002
37
Vitamin B12 deficiency may cause benign familial infantile convulsions: a case report. (10565467)
1999
38
Vitamin B12 deficiency: a new risk factor for breast cancer? (10518411)
1999
39
Delirium associated with vitamin B12 deficiency after pneumonia. (10626095)
1999
40
Improvement of P300 latency by treatment of vitamin B12 deficiency. (9563586)
1998
41
Infantile megaloblastosis secondary to maternal vitamin B12 deficiency. (9146943)
1997
42
Does folic acid harm people with vitamin B12 deficiency? (7796091)
1995
43
Urinary methylmalonic acid to detect vitamin B12 deficiency. (7723154)
1995
44
Nutritional vitamin B12 deficiency in a breastfed infant following maternal gastric bypass. (8060815)
1994
45
Vitamin B12 deficiency. (8463771)
1993
46
Correction of the DNA synthesis defect in vitamin B12 deficiency by tetrahydrofolate using the dU suppression test. (8136293)
1993
47
Vitamin B12 deficiency. (8463772)
1993
48
Prevalence of vitamin B12 deficiency among geriatric outpatients. (1331288)
1992
49
Biologically significant serum vitamin B12 deficiency in multiple sclerosis inadequately documented. (1497491)
1992
50
Adult celiac disease (celiac sprue), pernicious anemia and IgA deficiency. Case report and review of the relationships between vitamin B12 deficiency, small intestinal mucosal disease and immunoglobulin deficiency. (3734360)
1986

Variations for Vitamin B12 Deficiency

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Expression for genes affiliated with Vitamin B12 Deficiency

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Search GEO for disease gene expression data for Vitamin B12 Deficiency.

Pathways for genes affiliated with Vitamin B12 Deficiency

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Pathways related to Vitamin B12 Deficiency according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4GIF, TCN2
2
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.0MTR, MTHFR
3
Show member pathways
thioredoxin pathway36
9.0MTR, MTHFR
4
Show member pathways
Vitamin B12 Metabolism36
8.7GIF, TCN1, MTHFR
5
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
8.5TCN2, MTHFR, MTR
67.5MTR, MTHFR, TCN1, TCN2, GIF
7
Show member pathways
flavin biosynthesis IV (mammalian)36
molybdenum cofactor biosynthesis36
coenzyme A biosynthesis36
thiamin salvage III36
alanine biosynthesis III36
thio-molybdenum cofactor biosynthesis36
biotin-carboxyl carrier protein assembly36
7.5MTR, MTHFR, TCN1, TCN2, GIF
8
Show member pathways
7.5MTR, MTHFR, TCN1, TCN2, GIF

Compounds for genes affiliated with Vitamin B12 Deficiency

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 49PharmGKB
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Compounds related to Vitamin B12 Deficiency according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1cobinamide43 2410.7MTR, TCN1
25-Methyltetrahydrofolic acid249.4MTHFR, MTR
3methyl-group439.4MTHFR, MTR
45,10-methenyltetrahydrofolate439.4MTR, MTHFR
5b vitamins439.4MTHFR, MTR
610-formyltetrahydrofolate439.4MTHFR, MTR
75-methyltetrahydrofolate43 1210.3MTR, MTHFR
8benazepril43 49 1211.3MTR, MTHFR
9tetrahydrofolate439.3MTHFR, MTR
10betaine43 2410.3MTR, MTHFR
11Tetrahydrofolic acid24 1210.3MTR, MTHFR
12corrinoid439.3TCN2, TCN1, MTR
13dihydrofolate439.3MTR, MTHFR
14pyridoxal 5-phosphate439.3MTR, MTHFR
15s-adenosylhomocysteine43 2410.2MTHFR, MTR
16purine43 2410.2MTR, MTHFR
17thymidylate439.2MTR, MTHFR
18s-adenosylmethionine43 24 1211.1MTHFR, MTR
19carbon439.1MTR, MTHFR
20cyclophosphamide43 49 1211.0MTR, MTHFR
21methotrexate49 43 1211.0MTR, MTHFR
22FAD248.9MTHFR, MTR
23adenosylcobalamin43 249.9TCN2, MTHFR, MTR
24cystathionine438.9TCN2, MTHFR, MTR
25vitamin b6438.9TCN2, MTHFR, MTR
26folate438.8MTR, MTHFR, TCN2
27creatinine438.8TCN2, MTHFR, MTR
28cobalt43 249.7MTR, TCN1, TCN2, GIF
29valine438.7MTR, MTHFR
30methylcobalamin43 249.5TCN2, TCN1, MTHFR, MTR
31cyanocobalamin49 24 1210.5TCN2, TCN1, MTHFR, MTR
32hydroxocobalamin43 129.5TCN2, TCN1, MTHFR, MTR
33methylmalonic acid43 249.5MTR, MTHFR, TCN1, TCN2
34homocysteine43 249.4MTR, MTHFR, TCN1, TCN2
35methionine438.4MTR, MTHFR, TCN1, TCN2
36cobalamin43 248.9MTR, MTHFR, TCN1, TCN2, GIF
37vitamin b12437.9GIF, TCN2, TCN1, MTHFR, MTR

GO Terms for genes affiliated with Vitamin B12 Deficiency

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Cellular components related to Vitamin B12 Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:00432029.3TCN2, GIF
2endosomeGO:00057689.1TCN2, GIF
3extracellular regionGO:00055769.0TCN1, TCN2, GIF

Biological processes related to Vitamin B12 Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cobalamin transportGO:00158898.9GIF, TCN2, TCN1
2cobalt ion transportGO:00068248.7GIF, TCN2, TCN1
3cobalamin metabolic processGO:00092358.4GIF, TCN2, TCN1, MTR
4water-soluble vitamin metabolic processGO:00067677.6MTR, MTHFR, TCN1, TCN2, GIF
5vitamin metabolic processGO:00067667.6GIF, TCN2, TCN1, MTHFR, MTR
6small molecule metabolic processGO:00442817.5MTR, MTHFR, TCN1, TCN2, GIF

Molecular functions related to Vitamin B12 Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cobalamin bindingGO:00314198.4MTR, TCN1, TCN2, GIF

Products for genes affiliated with Vitamin B12 Deficiency

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Sources for Vitamin B12 Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet