MCID: VTM007
MIFTS: 28

Vitamin D-Dependent Rickets Type Ii malady

Summaries for Vitamin D-Dependent Rickets Type Ii

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MalaCards: Vitamin D-Dependent Rickets Type Ii, also known as vitamin d-dependent rickets type ii with alopecia, is related to rickets and rickets, vitamin d-resistant, type iia. An important gene associated with Vitamin D-Dependent Rickets Type Ii is VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds clodronate and 24(r),25-dihydroxyvitamin d3 have been mentioned in the context of this disorder.

Aliases & Classifications for Vitamin D-Dependent Rickets Type Ii

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20GeneTests, 22GTR, 44Novoseek, 60UMLS
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Aliases & Descriptions:

vitamin d-dependent rickets type ii 20 22
vitamin d-dependent rickets type ii with alopecia 60
vitamin d-dependent rickets, type ii 44
vitamin d-dependent rickets, type 2 60


Related Diseases for Vitamin D-Dependent Rickets Type Ii

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17GeneCards, 18GeneDecks
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Diseases in the Vitamin D-Dependent Rickets Type I family:

vitamin d-dependent rickets type ii

Diseases related to Vitamin D-Dependent Rickets Type Ii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1rickets31.7PTH, CYP27B1, VDR, BGLAP
2rickets, vitamin d-resistant, type iia30.5VDR, CYP27B1
3alopecia10.7
4myelofibrosis10.4
5hypervitaminosis d10.0CYP27B1
6addison's disease10.0CYP27B1
7osteonecrosis10.0BGLAP
8hypogonadism10.0BGLAP
9sarcoidosis10.0CYP27B1
10hyperostosis10.0BGLAP
11growth hormone deficiency10.0BGLAP
12acromegaly10.0BGLAP
13hypothyroidism10.0PTH
14hypertension10.0PTH
15osteosclerosis10.0PTH
16myeloma10.0BGLAP
17asthma10.0VDR
18psoriasis10.0VDR, CYP27B1
19rheumatoid arthritis10.0CYP27B1, BGLAP
20x-linked hypophosphatemia10.0VDR, CYP27B1
21primary biliary cirrhosis10.0VDR, BGLAP
22hypoparathyroidism10.0BGLAP, PTH
23hypersensitivity reaction type ii disease10.0VDR
24williams syndrome10.0VDR, CYP27B1
25pseudohypoparathyroidism type 1b10.0BGLAP, PTH
26basal cell carcinoma10.0CYP27B1, VDR
27hyperthyroidism10.0PTH, BGLAP
28osteitis fibrosa10.0PTH, BGLAP
29hyperphosphatemia10.0PTH, VDR
30parathyroid adenoma10.0PTH, VDR
31nephrolithiasis10.0PTH, VDR
32uremia10.0PTH, VDR
33pseudohypoparathyroidism10.0BGLAP, PTH
34ankylosing spondylitis10.0BGLAP, PTH
35adenoma10.0VDR, PTH
36primary hyperoxaluria10.0PTH, BGLAP
37metabolic acidosis10.0PTH, BGLAP
38type 1 diabetes10.0CYP27B1, VDR, BGLAP
39inflammatory bowel disease10.0CYP27B1, VDR, BGLAP
40graves' disease10.0CYP27B1, VDR, BGLAP
41goiter10.0PTH, BGLAP
42prostate cancer10.0CYP27B1, VDR, BGLAP
43renal osteodystrophy10.0PTH, VDR, BGLAP
44primary hyperparathyroidism10.0BGLAP, VDR, CYP27B1, PTH
45secondary hyperparathyroidism of renal origin10.0BGLAP, VDR, CYP27B1, PTH
46osteoporosis, postmenopausal10.0BGLAP, VDR, CYP27B1, PTH
47hypophosphatemia10.0BGLAP, VDR, CYP27B1, PTH
48osteomalacia10.0PTH, CYP27B1, VDR, BGLAP
49secondary syphilis10.0BGLAP, VDR, CYP27B1, PTH
50hypercalcemia10.0BGLAP, VDR, CYP27B1, PTH

Graphical network of the top 20 diseases related to Vitamin D-Dependent Rickets Type Ii:



Diseases related to vitamin d-dependent rickets type ii

Clinical Features for Vitamin D-Dependent Rickets Type Ii

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Drugs & Therapeutics for Vitamin D-Dependent Rickets Type Ii

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Vitamin D-Dependent Rickets Type Ii

Search CenterWatch for Vitamin D-Dependent Rickets Type Ii

Genetic Tests for Vitamin D-Dependent Rickets Type Ii

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20GeneTests, 22GTR
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Genetic tests related to Vitamin D-Dependent Rickets Type Ii:

id Genetic test Affiliating Genes
1 Vitamin D-Dependent Rickets Type Ii20 VDR
2 Vitamin D-Dependent Rickets, Type 222

Anatomical Context for Vitamin D-Dependent Rickets Type Ii

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Animal Models for Vitamin D-Dependent Rickets Type Ii or affiliated genes

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Publications for Vitamin D-Dependent Rickets Type Ii

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Genetic Variations for Vitamin D-Dependent Rickets Type Ii

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Expression for genes affiliated with Vitamin D-Dependent Rickets Type Ii

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitamin D-Dependent Rickets Type Ii

Search GEO for disease gene expression data for Vitamin D-Dependent Rickets Type Ii.

Pathways for genes affiliated with Vitamin D-Dependent Rickets Type Ii

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37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Pathways related to Vitamin D-Dependent Rickets Type Ii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CYP27B1, VDR
2
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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8.6PTH, VDR, BGLAP
3
Vitamin D2 (ergocalciferol) metabolism
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8.5VDR, CYP27B1, PTH
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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8.0PTH, CYP27B1, VDR, BGLAP

Compounds for genes affiliated with Vitamin D-Dependent Rickets Type Ii

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Vitamin D-Dependent Rickets Type Ii according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1clodronate44 49 1112.3VDR
224(r),25-dihydroxyvitamin d3449.8VDR, BGLAP
31,25(oh)2-16-ene-23-yne-d3449.8BGLAP, VDR
4kh 1060449.8BGLAP, VDR
522-oxacalcitriol449.8VDR, BGLAP
6Calcidiol11 2410.7VDR, CYP27B1
7thiazide449.7BGLAP, VDR
8calcifediol599.7VDR, CYP27B1
9hydrochlorothiazide44 49 28 11 2413.7VDR, BGLAP
10gemini449.7VDR, CYP27B1
11Ergocalciferol11 2410.7CYP27B1, VDR
12raloxifene44 28 49 1112.7BGLAP, VDR
13doxercalciferol449.5VDR, PTH
14calcium carbonate449.5PTH, BGLAP
15pamidronate44 49 1111.4BGLAP, PTH
16caffeine44 49 28 2 11 2414.4VDR, BGLAP
17hydroxyproline44 11 2411.3PTH, BGLAP
18alfacalcidol44 59 1111.2BGLAP, VDR, CYP27B1
1924,25-dihydroxyvitamin d3449.2BGLAP, VDR, CYP27B1
20calcipotriol44 59 28 1112.2CYP27B1, VDR, BGLAP
21eb 108944 5910.2BGLAP, VDR, CYP27B1
22estrone44 28 11 2412.2PTH, BGLAP
23dihydrotestosterone44 28 11 2412.1VDR, BGLAP
24deoxypyridinoline449.0PTH, VDR, BGLAP
25alendronate44 49 1111.0PTH, VDR, BGLAP
26thyroxine44 249.9BGLAP, VDR, PTH
27paricalcitol44 119.9VDR, CYP27B1, PTH
28tamoxifen44 49 28 1111.9PTH, VDR, BGLAP
29creatinine448.9PTH, VDR, BGLAP
30cysteine448.8CYP27B1, VDR, BGLAP
31dexamethasone44 49 28 1111.8PTH, VDR, BGLAP
32cycloheximide448.7PTH, CYP27B1, VDR
33arginine448.7BGLAP, VDR, PTH
34retinoic acid44 249.7BGLAP, VDR, CYP27B1
3525-hydroxyvitamin d448.4PTH, CYP27B1, VDR, BGLAP
36phosphorus448.4BGLAP, VDR, CYP27B1, PTH
371,25 dihydroxy vitamin d3448.4BGLAP, VDR, CYP27B1, PTH
38calcitriol44 59 11 2411.4BGLAP, VDR, CYP27B1, PTH
39vitamin d448.4BGLAP, VDR, CYP27B1, PTH
40testosterone44 59 11 2411.3BGLAP, VDR, CYP27B1, PTH
41estrogen448.3PTH, CYP27B1, VDR, BGLAP
42calcium44 49 11 2411.2BGLAP, VDR, CYP27B1, PTH

GO Terms for genes affiliated with Vitamin D-Dependent Rickets Type Ii

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16Gene Ontology
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Biological processes related to Vitamin D-Dependent Rickets Type Ii according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:0109809.6CYP27B1, VDR
2positive regulation of keratinocyte differentiationGO:0456189.5VDR, CYP27B1
3response to vitamin DGO:0332809.5CYP27B1, BGLAP
4regulation of bone mineralizationGO:0305009.4BGLAP, CYP27B1
5decidualizationGO:0466979.4CYP27B1, VDR
6calcium ion transportGO:0068169.3CYP27B1, VDR
7bone mineralizationGO:0302829.3CYP27B1, BGLAP
8response to estrogen stimulusGO:0436279.2BGLAP, CYP27B1
9cellular calcium ion homeostasisGO:0068748.8PTH, VDR
10skeletal system developmentGO:0015018.8PTH, VDR, BGLAP

Products for genes affiliated with Vitamin D-Dependent Rickets Type Ii

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vitamin D-Dependent Rickets Type Ii

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet