MCID: VTM001
MIFTS: 42

Vitamin K Deficiency Hemorrhagic Disease malady

Metabolic diseases category

Summaries for Vitamin K Deficiency Hemorrhagic Disease

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to hepatocellular carcinoma and hemorrhagic disease. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinone and other terpenoid-quinone biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds vitamin k hydroquinone and Phytonadione have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are cardiovascular system and mortality/aging.

Wikipedia:63 Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body needs for... more...

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

vitamin k deficiency hemorrhagic disease 8 10
vitamin k deficiency 8 44 60
deficiency of vitamin k 8
vitamin k 33


External Ids:

Disease Ontology8 DOID:11249
ICD9CM27 269.0
SNOMED-CT56 52675005, 124892003
MeSH34 D014813
ICD1025 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

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17GeneCards, 18GeneDecks
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Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma30.8F2, F7, F9
2hemorrhagic disease30.6F2, F3, F9
3cystic fibrosis30.3F9
4pseudoxanthoma elasticum30.2MGP, GGCX
5hepatitis30.2F9, F2
6protein c deficiency30.1F9, PROS1, F2
7atherosclerosis30.1GAS6, MGP, VKORC1, F7, F3
8cholestasis30.1F2
9hemarthrosis30.1F9, F3
10lupus erythematosus30.1F2, F3, PROS1
11disseminated intravascular coagulation30.1F9, F7, F3, F2
12prostatitis29.9PROS1
13hepatitis a29.9F2
14prostate cancer29.9BGLAP, GAS6, PROS1
15antiphospholipid syndrome29.9F2, F3, PROS1
16protein s deficiency29.9F2, F3, PROS1
17hemophilia b29.9F9, F7, F3, F2
18thrombocytopenia29.9F2, F3, F7, F9
19pulmonary embolism29.9F9, PROS1, F3, F2
20prothrombin deficiency10.4
21vitamin k-dependent coagulation defect10.4
22vitamin k-dependent clotting factors, combined deficiency of, 210.4
23biliary atresia10.3
24hereditary resistance to anti-vitamin k10.3
25vitamin k-dependent clotting factors, combined deficiency of, 110.3
26liver disease10.3
27kidney disease10.2
28bone fracture10.1
29calciphylaxis10.1
30hepatitis b10.1
31aortic atherosclerosis10.1
32pancreatitis10.1
33retinal vein occlusion10.1
34retinitis10.1
35tuberculosis10.1
36uremia10.1
37binder syndrome10.1
38parkinson's disease10.1
39abetalipoproteinemia10.1
40systemic lupus erythematosus10.1
41diabetes insipidus10.1
42celiac disease10.1
43choledochal cyst10.1
44hemolytic-uremic syndrome10.1
45osteoporosis10.1
46cervicitis10.1
47paraplegia10.1
48purpura10.1
49chondrodysplasia punctata 2, x-linked10.1
50glomerulonephritis10.0GAS6

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Clinical Features for Vitamin K Deficiency Hemorrhagic Disease

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Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vitamin K Deficiency Hemorrhagic Disease

Drug clinical trials:

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Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Search CenterWatch for Vitamin K Deficiency Hemorrhagic Disease

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

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Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

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32MalaCards
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MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

32
Bone

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.4GGCX, F9, GAS6, F7, F3, F2
2MP:00107686.6GAS6, MGP, PROS1, F7, F3, F2
3MP:00053766.4F9, GAS6, VKORC1, PROS1, F7, F3

Publications for Vitamin K Deficiency Hemorrhagic Disease

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50PubMed
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Articles related to Vitamin K Deficiency Hemorrhagic Disease:

idTitleAuthorsYear
1
Hemorrhagic disease in an infant fed on a vitamin K-deficient soya formula. (8956177)
1996
2
Hemorrhagic disease in pigs associated with vitamin K deficiency. (7182633)
1982
3
Hemorrhagic disease due to vitamin K deficiency in a premature infant: a syndrome which may resemble disseminated intravascular coagulation (DIC). (4196842)
1973
4
The relation of vitamin K deficiency to hemorrhagic disease of the newborn. (14952375)
1952

Genetic Variations for Vitamin K Deficiency Hemorrhagic Disease

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Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 52R&D Systems, 49PharmGKB
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Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GGCX, VKORC1
29.6MGP, BGLAP
39.0GAS6, PROS1, F2
4
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8.8F7, PROS1, GAS6, F9
5
Hide members
8.1PROS1, F7, F3, F2
6
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7.6F9, PROS1, F7, F3, F2
7
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7.6F9, PROS1, F7, F3, F2
8
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7.6F9, PROS1, F7, F3, F2
9
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7.5F9, GAS6, VKORC1, PROS1, F7, F2
107.5F9, GAS6, VKORC1, PROS1, F7, F2
11
Hide members
5.8GGCX, BGLAP, F9, F2, F3, F7

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1vitamin k hydroquinone4410.2GGCX, VKORC1
2Phytonadione1110.0GGCX, BGLAP
3aprosulate4410.0F3
45-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)119.8F2, F7
5fluindione44 4910.8VKORC1, F2
6mononine449.7F9, F2
7aspartate449.7F2, F7
8[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA119.6F3, F7
9{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID119.6F3, F7
102-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE119.6F7, F3
11Coagulation Factor IX119.6GGCX, F2, F7
12Drotrecogin alfa119.4PROS1, F2, GGCX
13Coagulation factor VIIa119.4F7, F3, GGCX
14brodifacoum449.4F2, F3
15napsagatran449.4F2, F3
16Gamma-Carboxy-Glutamic Acid119.3F2, F9, BGLAP
17hemochron449.3F3, F2
18certoparin449.3F3, F2
19appt449.2F3, F2
20inogatran449.2F2, F3
21heparin sodium449.1F2, F3
22warfarin44 49 11 2412.1MGP, GAS6, F9, VKORC1, GGCX
23vitamin k epoxide449.1BGLAP, VKORC1, F2, GGCX
24ecarin449.1F3, F2
25dextran 70449.0F3, F2
26polybrene449.0F2, F3
27levonorgestrel44 59 28 1112.0F7, F3, F2
28kaolin449.0F9, F3, F2
29organon449.0F9, F3, F2
30fondaparinux449.0F9, F3, F2
31tranexamic acid44 1110.0F2, F3, F9
32epsilon aminocaproic acid449.0F9, F3, F2
33ristocetin449.0F2, F3, F9
34desmopressin44 59 28 1111.9F9, F3, F2
35hirudin448.8F9, F3, F2
36dermatan sulfate448.8F9, F3, F2
37spectrozyme448.7F2, F3
38acenocoumarol44 49 1110.7F2, F3, VKORC1, F9
39phenprocoumon44 49 1110.7F9, VKORC1, F3, F2
40coumarin44 2 49 2411.7F9, VKORC1, F3, F2
41kininogen448.6F2, F3, F7, F9
42phosphatidylserine44 28 1110.5F2, F3, GAS6, F9
43vitamin k144 249.2BGLAP, MGP, VKORC1, F3, F2
44coumarins448.2F2, F3, VKORC1, F9, BGLAP
45heparin44 28 11 2410.8BGLAP, F9, PROS1, F3, F2
46menadione44 11 249.7BGLAP, GGCX, F2, F7, PROS1, VKORC1
47creatinine447.5BGLAP, F9, PROS1, F7, F3, F2
48calcium44 49 11 2410.5BGLAP, F9, GAS6, MGP, PROS1, F7
49serine447.1BGLAP, F9, MGP, PROS1, F7, F3
50gamma-carboxyglutamic acid446.2GGCX, F2, F3, F7, PROS1, VKORC1

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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16Gene Ontology
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Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057888.6F9, GAS6, F7, F2
2Golgi lumenGO:0057968.1F2, F7, PROS1, GAS6, F9
3extracellular spaceGO:0056157.8F2, F3, F7, GAS6, BGLAP
4extracellular regionGO:0055767.3BGLAP, F9, GAS6, PROS1, F7, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:0325719.8BGLAP, F7
2organ regenerationGO:0311009.7F7, GAS6
3regulation of bone mineralizationGO:0305009.7MGP, BGLAP
4positive regulation of blood coagulationGO:0301949.6F7, F2
5positive regulation of platelet-derived growth factor receptor signaling pathwayGO:0106419.5F7, F3
6blood coagulation, intrinsic pathwayGO:0075979.5F2, F9
7positive regulation of positive chemotaxisGO:0509279.4F3, F7
8fibrinolysisGO:0427309.3F2, PROS1
9cellular response to growth factor stimulusGO:0713639.3GAS6, BGLAP
10leukocyte migrationGO:0509009.2F2, PROS1, GAS6
11positive regulation of protein kinase B signaling cascadeGO:0518979.1GAS6, F7, F3
12blood coagulation, extrinsic pathwayGO:0075989.1F3, F7, F9
13platelet activationGO:0301688.9GAS6, PROS1, F2
14proteolysisGO:0065088.4F2, F7, PROS1, GAS6, F9
15peptidyl-glutamic acid carboxylationGO:0171877.8GGCX, F9, GAS6, VKORC1, PROS1, F7
16post-translational protein modificationGO:0436877.8F9, GAS6, VKORC1, PROS1, F7, F2
17cellular protein metabolic processGO:0442677.8F9, GAS6, VKORC1, PROS1, F7, F2
18blood coagulationGO:0075967.3F9, GAS6, PROS1, F7, F3, F2

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:0081479.5BGLAP, MGP
2receptor bindingGO:0051029.1F2, F7, GAS6
3serine-type endopeptidase activityGO:0042528.7F2, F7, F9
4calcium ion bindingGO:0055097.2F2, F7, PROS1, MGP, GAS6, F9

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Vitamin K Deficiency Hemorrhagic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet