MCID: VTM001
MIFTS: 40

Vitamin K Deficiency Hemorrhagic Disease malady

Metabolic diseases category
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Summaries for Vitamin K Deficiency Hemorrhagic Disease

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MedlinePlus:33 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards based summary: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to warfarin resistance and pseudoxanthoma elasticum. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinol biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds Vitamin K1 2,3-epoxide and vitamin k hydroquinone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are mortality/aging and cardiovascular system.

Wikipedia:65 Vitamin K is a group of structurally similar, fat-soluble vitamins the human body needs for complete... more...

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

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Vitamin K Deficiency Hemorrhagic Disease, Aliases & Descriptions:

Name: Vitamin K Deficiency Hemorrhagic Disease 8 10
Vitamin K Deficiency 8 44 62
 
Deficiency of Vitamin K 8 62
Vitamin K 33


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:11249
ICD9CM27 269.0
SNOMED-CT57 124892003, 52675005
MeSH34 D014813
ICD1025 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

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Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1warfarin resistance31.5VKORC1
2pseudoxanthoma elasticum30.7MGP, GGCX
3hemorrhagic disease30.7F2, F3
4thromboembolism30.5F3, F2, F7
5protein s deficiency30.1F2, F3
6pulmonary embolism30.1F2, F3
7antiphospholipid syndrome30.0F3, F2
8lupus erythematosus30.0F3, F2
9disseminated intravascular coagulation30.0F2, F3, F7
10venous thrombosis30.0F3, F2
11hemophilia b29.8F7, F3, F2
12thrombocytopenia29.8F2, F3, F7
13atherosclerosis29.8VKORC1, F3, MGP, F7
14hepatocellular carcinoma10.6
15prothrombin deficiency10.5
16warfarin sensitivity10.5
17venous thromboembolism10.5
18vitamin k-dependent clotting factors, combined deficiency of, 110.4
19vitamin k-dependent clotting factors, combined deficiency of, 210.4
20glanzmann's thrombasthenia10.4F7
21biliary atresia10.4
22chondrodysplasia10.4
23varicose veins10.4F2
24hereditary resistance to anti-vitamin k10.3
25cystic fibrosis10.3
26liver disease10.3
27factor xii deficiency10.3F3
28kidney disease10.3
29aortic atherosclerosis10.2
30bone fracture10.2
31hepatitis10.2
32hepatitis b10.2
33retinal vein occlusion10.2
34calciphylaxis10.2
35protein c deficiency10.2
36pancreatitis10.2
37retinitis10.2
38tuberculosis10.2
39uremia10.2
40celiac disease10.1
41osteoporosis10.1
42parkinson's disease10.1
43systemic lupus erythematosus10.1
44binder syndrome10.1
45abetalipoproteinemia10.1
46choledochal cyst10.1
47hemarthrosis10.1
48diabetes insipidus10.1
49hemolytic-uremic syndrome10.1
50cervicitis10.1

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Symptoms for Vitamin K Deficiency Hemorrhagic Disease

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Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

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Drug clinical trials:

Search ClinicalTrials for Vitamin K Deficiency Hemorrhagic Disease

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

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Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

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MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

32
Bone

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

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MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8F7, GGCX, F3, MGP, F2
2MP:00053857.5F2, MGP, F3, GGCX, F7
3MP:00053767.3F7, GGCX, VKORC1, F3, MGP, F2

Publications for Vitamin K Deficiency Hemorrhagic Disease

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Variations for Vitamin K Deficiency Hemorrhagic Disease

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Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Expression patterns in normal tissues for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
ubiquinol-10 biosynthesis (eukaryotic)37
all-trans-decaprenyl diphosphate biosynthesis37
9.6VKORC1, GGCX
29.4BGLAP, MGP
3
Show member pathways
thioredoxin pathway37
9.4F7, F2
4
Show member pathways
8.6F7, F3, F2
5
Show member pathways
8.6F2, F3, F7
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.6F7, F3, F2
7
Show member pathways
8.6F7, F3, F2
8
Show member pathways
8.6F2, VKORC1, GGCX, F7
9
Show member pathways
7.6BGLAP, VKORC1, GGCX, F7, MGP, F2

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1Vitamin K1 2,3-epoxide2410.1VKORC1, GGCX
2vitamin k hydroquinone4410.1GGCX, VKORC1
3fluindione50 4410.9F2, VKORC1
4r-warfarin449.8F2, VKORC1
5calcium oxalate449.8F2, GGCX
6aprosulate449.6F2, F3
7napsagatran449.6F2, F3
8brodifacoum449.5F2, F3
9mnpt449.5F3, F2
10certoparin449.5F2, F3
11appt449.5F2, F3
12hemochron449.5F2, F3
13heparin sodium449.5F2, F3
14inogatran449.5F2, F3
15ecarin449.5F3, F2
16dextran 70449.5F3, F2
17polybrene449.5F2, F3
18spectrozyme449.5F2, F3
19s-warfarin449.5F2, F3
20danaparoid449.5F2, F3
21hepaplastin449.5F2, F3
22rivaroxaban44 1110.4F2, F3
23kaolin449.4F2, F3
24ximelagatran44 1110.4F2, F3
25organon449.4F2, F3
26heparinoids449.4F3, F2
27fondaparinux449.4F3, F2
28bivalirudin44 1110.3F2, F3
29hydroxyethyl starch449.3F2, F3
30argatroban44 1110.2F2, F3
31ppack449.2F3, F2
32vitamin k2449.2GGCX, BGLAP
33tranexamic acid44 1110.1F2, F3
34acenocoumarol44 50 1111.1F2, F3, VKORC1
35phenprocoumon44 50 1111.1VKORC1, F3, F2
36coumarin44 2 50 2412.1F2, F3, VKORC1
37levonorgestrel44 61 28 1112.0F7, F3, F2
38protamine sulfate449.0F2, F3
39kininogen449.0F7, F3, F2
40vitamin k epoxide448.9F2, BGLAP, VKORC1, GGCX
41calcitriol44 61 24 1111.9BGLAP, MGP, F2
42simvastatin44 50 61 28 24 1113.7F2, BGLAP, F3
43coumarins448.5VKORC1, F3, BGLAP, F2
44menadione44 24 1110.4F2, BGLAP, VKORC1, GGCX, F7
45creatinine448.3F7, F3, BGLAP, F2
46aspartate448.3F2, BGLAP, F3, F7
47vitamin k144 249.1VKORC1, F3, BGLAP, MGP, F2
48serine447.8F7, F3, BGLAP, MGP, F2
49warfarin44 50 24 1110.2F7, GGCX, VKORC1, F3, BGLAP, MGP
50gamma-carboxyglutamic acid447.2BGLAP, MGP, F2, F3, VKORC1, F7

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.4F7, F2
2extracellular spaceGO:0056157.7F7, F3, BGLAP, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:0325719.6BGLAP, F7
2positive regulation of blood coagulationGO:0301949.4F2, F7
3regulation of bone mineralizationGO:0305009.3BGLAP, MGP
4positive regulation of platelet-derived growth factor receptor signaling pathwayGO:0106419.3F3, F7
5blood coagulation, extrinsic pathwayGO:0075989.3F7, F3
6positive regulation of positive chemotaxisGO:0509279.2F7, F3
7positive regulation of protein kinase B signalingGO:0518979.1F7, F3
8response to estrogenGO:0436279.0F7, BGLAP
9peptidyl-glutamic acid carboxylationGO:0171878.9F7, GGCX, VKORC1, F2
10post-translational protein modificationGO:0436878.8F2, VKORC1, GGCX, F7
11cellular protein metabolic processGO:0442678.7F7, GGCX, VKORC1, F2
12blood coagulationGO:0075968.4F2, F3, GGCX, F7

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:0081479.1BGLAP, MGP
2calcium ion bindingGO:0055098.4F7, BGLAP, MGP, F2

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources for Vitamin K Deficiency Hemorrhagic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet