MCID: VTM001
MIFTS: 38

Vitamin K Deficiency Hemorrhagic Disease malady

Metabolic category

Summaries for Vitamin K Deficiency Hemorrhagic Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to warfarin resistance and thromboembolism. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinone and other terpenoid-quinone biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds vitamin k hydroquinone and aprosulate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, and related mouse phenotypes are cardiovascular system and mortality/aging.

Wikipedia:64 Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body needs for... more...

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

vitamin k deficiency hemorrhagic disease 8 10
vitamin k deficiency 8 45 61
deficiency of vitamin k 8
vitamin k 34


External Ids:

Disease Ontology8 DOID:11249
ICD9CM27 269.0
SNOMED-CT57 52675005, 124892003
MeSH35 D014813
ICD1025 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1warfarin resistance30.9VKORC1
2thromboembolism30.7F9, F7, F3, F2
3warfarin sensitivity30.5F9
4cystic fibrosis30.4F9
5protein s deficiency30.3F2, F3, PROS1
6hepatitis a30.2F2
7pseudoxanthoma elasticum30.2MGP, GGCX
8atherosclerosis30.2GAS6, MGP, VKORC1, F7, F3
9hemarthrosis30.1F9, F3
10factor v deficiency30.1F2, F3
11protein c deficiency30.0F9, PROS1, F2
12antiphospholipid syndrome30.0F2, F3, PROS1
13hemophilia b29.9F9, F7, F3, F2
14thrombocytopenia29.9F2, F3, F7, F9
15venous thrombosis29.9F2, F3, PROS1, F9
16prothrombin deficiency10.5
17venous thromboembolism10.5
18vitamin k-dependent coagulation defect10.4
19vitamin k-dependent clotting factors, combined deficiency of, 210.4
20biliary atresia10.4
21chondrodysplasia10.4
22hereditary resistance to anti-vitamin k10.3
23vitamin k-dependent clotting factors, combined deficiency of, 110.3
24bone fracture10.2
25hepatitis c10.2
26calciphylaxis10.2
27aortic atherosclerosis10.2
28tuberculosis10.2
29uremia10.2
30hepatitis c virus10.2
31binder syndrome10.1
32abetalipoproteinemia10.1
33systemic lupus erythematosus10.1
34diabetes insipidus10.1
35celiac disease10.1
36choledochal cyst10.1
37hemolytic-uremic syndrome10.1
38osteoporosis10.1
39chondrodysplasia punctata 2, x-linked10.1
40diffuse alveolar hemorrhage10.1
41osteoporotic fracture10.0
42crohn's disease10.0
43atrophic gastritis10.0
44obstructive jaundice10.0
45hepatitis e10.0
46metachromatic leukodystrophy10.0
47lichen planus10.0
48bacterial gastritis10.0
49short bowel syndrome10.0
50hypervitaminosis a10.0

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Clinical Features for Vitamin K Deficiency Hemorrhagic Disease

Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vitamin K Deficiency Hemorrhagic Disease

Drug clinical trials:

Search ClinicalTrials for Vitamin K Deficiency Hemorrhagic Disease

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Search CenterWatch for Vitamin K Deficiency Hemorrhagic Disease

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

33
Small intestine

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.4GGCX, F2, F3, F7, GAS6, F9
2MP:00107686.6F9, GAS6, PROS1, F7, F3, F2
3MP:00053766.4F2, F3, F7, PROS1, VKORC1, GAS6

Publications for Vitamin K Deficiency Hemorrhagic Disease

Genetic Variations for Vitamin K Deficiency Hemorrhagic Disease

Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GGCX, VKORC1
29.6MGP, BGLAP
39.0GAS6, PROS1, F2
4
Hide members
8.8F7, PROS1, GAS6, F9
5
Hide members
8.1PROS1, F7, F3, F2
6
Hide members
7.6F9, PROS1, F7, F3, F2
7
Hide members
7.6F9, PROS1, F7, F3, F2
8
Hide members
7.6F9, PROS1, F7, F3, F2
9
Hide members
7.5F9, GAS6, VKORC1, PROS1, F7, F2
107.5F9, GAS6, VKORC1, PROS1, F7, F2
11
Hide members
5.8GGCX, BGLAP, F9, F2, F3, F7

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1vitamin k hydroquinone4510.2GGCX, VKORC1
2aprosulate4510.0F3
3Phytonadione1110.0BGLAP, GGCX
45-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)119.8F2, F7
5mononine459.8F9, F2
6aspartate459.7F2, F7
7fluindione45 5010.7VKORC1, F2
82-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE119.6F3, F7
9{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID119.6F7, F3
10Coagulation Factor IX119.6F2, GGCX, F7
11[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA119.6F3, F7
12Drotrecogin alfa119.4PROS1, GGCX, F2
13brodifacoum459.4F2, F3
14napsagatran459.4F3, F2
15Coagulation factor VIIa119.4F7, F3, GGCX
16Gamma-Carboxy-Glutamic Acid119.3BGLAP, F9, F2
17certoparin459.3F2, F3
18appt459.3F2, F3
19hemochron459.3F2, F3
20inogatran459.2F3, F2
21heparin sodium459.1F3, F2
22warfarin45 50 11 2412.1MGP, GAS6, F9, VKORC1, GGCX
23vitamin k epoxide459.1BGLAP, F2, GGCX, VKORC1
24dextran 70459.1F2, F3
25ecarin459.0F2, F3
26spectrozyme459.0F3, F2
27levonorgestrel45 60 29 1112.0F7, F3, F2
28organon459.0F9, F2, F3
29kaolin459.0F3, F2, F9
30fondaparinux459.0F9, F3, F2
31tranexamic acid45 1110.0F9, F2, F3
32epsilon aminocaproic acid459.0F2, F3, F9
33ristocetin459.0F2, F9, F3
34desmopressin45 60 29 1111.9F9, F2, F3
35hirudin458.8F9, F3, F2
36dermatan sulfate458.8F2, F9, F3
37polybrene458.7F3, F2
38acenocoumarol45 50 1110.7F9, VKORC1, F3, F2
39phenprocoumon45 50 1110.7F3, VKORC1, F9, F2
40coumarin45 2 50 2411.7VKORC1, F3, F9, F2
41kininogen458.6F7, F2, F3, F9
42phosphatidylserine45 29 1110.5F2, F9, GAS6, F3
43vitamin k145 249.2BGLAP, MGP, VKORC1, F3, F2
44coumarins458.2F2, F3, VKORC1, F9, BGLAP
45heparin45 29 11 2410.8BGLAP, PROS1, F3, F9, F2
46menadione45 11 249.7F7, F9, BGLAP, VKORC1, PROS1, GGCX
47creatinine457.5F2, F3, F9, F7, PROS1, BGLAP
48calcium45 50 11 2410.5MGP, BGLAP, PROS1, GGCX, GAS6, F9
49serine457.1F3, BGLAP, F2, MGP, F9, F7
50gamma-carboxyglutamic acid456.2VKORC1, F7, PROS1, MGP, GAS6, F3

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057888.6F9, GAS6, F7, F2
2Golgi lumenGO:0057968.1F2, F7, PROS1, GAS6, F9
3extracellular spaceGO:0056157.8F2, F3, F7, GAS6, BGLAP
4extracellular regionGO:0055767.3BGLAP, F9, GAS6, PROS1, F7, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:0325719.8BGLAP, F7
2organ regenerationGO:0311009.7F7, GAS6
3regulation of bone mineralizationGO:0305009.7MGP, BGLAP
4positive regulation of blood coagulationGO:0301949.6F7, F2
5positive regulation of platelet-derived growth factor receptor signaling pathwayGO:0106419.5F7, F3
6blood coagulation, intrinsic pathwayGO:0075979.5F2, F9
7positive regulation of positive chemotaxisGO:0509279.4F3, F7
8fibrinolysisGO:0427309.3F2, PROS1
9cellular response to growth factor stimulusGO:0713639.3GAS6, BGLAP
10leukocyte migrationGO:0509009.2F2, PROS1, GAS6
11positive regulation of protein kinase B signaling cascadeGO:0518979.1GAS6, F7, F3
12blood coagulation, extrinsic pathwayGO:0075989.1F3, F7, F9
13platelet activationGO:0301688.9GAS6, PROS1, F2
14proteolysisGO:0065088.4F2, F7, PROS1, GAS6, F9
15peptidyl-glutamic acid carboxylationGO:0171877.8GGCX, F9, GAS6, VKORC1, PROS1, F7
16post-translational protein modificationGO:0436877.8F9, GAS6, VKORC1, PROS1, F7, F2
17cellular protein metabolic processGO:0442677.8F9, GAS6, VKORC1, PROS1, F7, F2
18blood coagulationGO:0075967.3F9, GAS6, PROS1, F7, F3, F2

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:0081479.5BGLAP, MGP
2receptor bindingGO:0051029.1F2, F7, GAS6
3serine-type endopeptidase activityGO:0042528.7F2, F7, F9
4calcium ion bindingGO:0055097.2F2, F7, PROS1, MGP, GAS6, F9

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vitamin K Deficiency Hemorrhagic Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet