MCID: VTM001
MIFTS: 37

Vitamin K Deficiency Hemorrhagic Disease malady

Summaries for Vitamin K Deficiency Hemorrhagic Disease

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35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to warfarin resistance and vitamin k-dependent coagulation defect. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinol biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds Vitamin K1 2,3-epoxide and vitamin k hydroquinone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are mortality/aging and cardiovascular system.

Wikipedia:66 Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body needs for... more...

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:



Aliases & Descriptions:

vitamin k deficiency hemorrhagic disease 9 11
vitamin k deficiency 9 46 63
deficiency of vitamin k 9
vitamin k 35


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Disease Ontology9 DOID:11249
MeSH36 D014813
SNOMED-CT59 124892003, 52675005
ICD9CM28 269.0
ICD1026 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

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18GeneCards, 19GeneDecks
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Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1warfarin resistance31.0VKORC1
2vitamin k-dependent coagulation defect30.8GGCX
3thromboembolism30.7F2, F3, F7
4hemorrhagic disease30.7F2, F3
5pseudoxanthoma elasticum30.4MGP, GGCX
6lupus erythematosus30.1F2, F3
7disseminated intravascular coagulation30.1F2, F3, F7
8atherosclerosis30.1MGP, F3, VKORC1, F7
9protein s deficiency30.0F2, F3
10pulmonary embolism30.0F3, F2
11antiphospholipid syndrome30.0F3, F2
12venous thrombosis30.0F3, F2
13hemophilia b30.0F7, F3, F2
14thrombocytopenia30.0F7, F3, F2
15hepatocellular carcinoma10.6
16prothrombin deficiency10.5
17warfarin sensitivity10.5
18venous thromboembolism10.5
19vitamin k-dependent clotting factors, combined deficiency of, 210.4
20biliary atresia10.4
21chondrodysplasia10.4
22hereditary resistance to anti-vitamin k10.3
23vitamin k-dependent clotting factors, combined deficiency of, 110.3
24cystic fibrosis10.3
25liver disease10.3
26kidney disease10.3
27bone fracture10.2
28hepatitis b10.2
29aortic atherosclerosis10.2
30calciphylaxis10.2
31protein c deficiency10.2
32hepatitis10.2
33pancreatitis10.2
34retinal vein occlusion10.2
35retinitis10.2
36tuberculosis10.2
37uremia10.2
38abetalipoproteinemia10.1
39diabetes insipidus10.1
40celiac disease10.1
41choledochal cyst10.1
42hemarthrosis10.1
43hemolytic-uremic syndrome10.1
44systemic lupus erythematosus10.1
45parkinson's disease10.1
46binder syndrome10.1
47cervicitis10.1
48cholestasis10.1
49osteoporosis10.1
50paraplegia10.1

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Symptoms for Vitamin K Deficiency Hemorrhagic Disease

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Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

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Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

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34MalaCards
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MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

34
Bone

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8F7, GGCX, F3, MGP, F2
2MP:00053857.5F2, MGP, F3, GGCX, F7
3MP:00053767.3F7, GGCX, VKORC1, F3, MGP, F2

Publications for Vitamin K Deficiency Hemorrhagic Disease

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Variations for Vitamin K Deficiency Hemorrhagic Disease

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Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 55R&D Systems, 52PharmGKB
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Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
ubiquinol-10 biosynthesis (eukaryotic)39
all-trans-decaprenyl diphosphate biosynthesis39
9.6GGCX, VKORC1
29.4MGP, BGLAP
3
Show member pathways
thioredoxin pathway39
9.4F7, F2
4
Show member pathways
8.6F7, F3, F2
5
Show member pathways
8.6F2, F3, F7
6
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.6F7, F3, F2
7
Show member pathways
8.6F2, F3, F7
8
Show member pathways
8.6F7, GGCX, VKORC1, F2
9
Show member pathways
7.6F7, GGCX, VKORC1, BGLAP, MGP, F2

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources:
25HMDB, 46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1Vitamin K1 2,3-epoxide2510.1VKORC1, GGCX
2vitamin k hydroquinone4610.1GGCX, VKORC1
3fluindione52 4610.9F2, VKORC1
4r-warfarin469.8F2, VKORC1
5calcium oxalate469.8F2, GGCX
6aprosulate469.6F2, F3
7napsagatran469.6F2, F3
8brodifacoum469.5F2, F3
9mnpt469.5F3, F2
10certoparin469.5F2, F3
11appt469.5F2, F3
12hemochron469.5F2, F3
13heparin sodium469.5F2, F3
14inogatran469.5F2, F3
15ecarin469.5F3, F2
16dextran 70469.5F3, F2
17polybrene469.5F2, F3
18spectrozyme469.5F2, F3
19s-warfarin469.5F2, F3
20danaparoid469.5F2, F3
21hepaplastin469.5F2, F3
22rivaroxaban46 1210.4F2, F3
23kaolin469.4F2, F3
24ximelagatran46 1210.4F2, F3
25organon469.4F2, F3
26heparinoids469.4F3, F2
27fondaparinux469.4F3, F2
28bivalirudin46 1210.3F2, F3
29hydroxyethyl starch469.3F2, F3
30argatroban46 1210.2F2, F3
31ppack469.2F3, F2
32vitamin k2469.2GGCX, BGLAP
33tranexamic acid46 1210.1F2, F3
34acenocoumarol46 52 1211.1F2, F3, VKORC1
35phenprocoumon46 52 1211.1VKORC1, F3, F2
36coumarin46 3 52 2512.1F2, F3, VKORC1
37levonorgestrel46 62 30 1212.0F7, F3, F2
38protamine sulfate469.0F2, F3
39kininogen469.0F7, F3, F2
40vitamin k epoxide468.9F2, BGLAP, VKORC1, GGCX
41calcitriol46 62 25 1211.9BGLAP, MGP, F2
42simvastatin46 52 62 30 25 1213.7F2, BGLAP, F3
43coumarins468.5VKORC1, F3, BGLAP, F2
44menadione46 25 1210.4F2, BGLAP, VKORC1, GGCX, F7
45creatinine468.3F7, F3, BGLAP, F2
46aspartate468.3F2, BGLAP, F3, F7
47vitamin k146 259.1VKORC1, F3, BGLAP, MGP, F2
48serine467.8F7, F3, BGLAP, MGP, F2
49warfarin46 52 25 1210.2F7, GGCX, VKORC1, F3, BGLAP, MGP
50gamma-carboxyglutamic acid467.2BGLAP, MGP, F2, F3, VKORC1, F7

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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17Gene Ontology
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Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.4F7, F2
2extracellular spaceGO:0056157.7F7, F3, BGLAP, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:0325719.6BGLAP, F7
2positive regulation of blood coagulationGO:0301949.4F2, F7
3regulation of bone mineralizationGO:0305009.3BGLAP, MGP
4positive regulation of platelet-derived growth factor receptor signaling pathwayGO:0106419.3F3, F7
5blood coagulation, extrinsic pathwayGO:0075989.3F7, F3
6positive regulation of positive chemotaxisGO:0509279.2F7, F3
7positive regulation of protein kinase B signalingGO:0518979.1F7, F3
8response to estrogenGO:0436279.0F7, BGLAP
9peptidyl-glutamic acid carboxylationGO:0171878.9F7, GGCX, VKORC1, F2
10post-translational protein modificationGO:0436878.8F2, VKORC1, GGCX, F7
11cellular protein metabolic processGO:0442678.7F7, GGCX, VKORC1, F2
12blood coagulationGO:0075968.4F2, F3, GGCX, F7

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:0081479.1BGLAP, MGP
2calcium ion bindingGO:0055098.4F7, BGLAP, MGP, F2

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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  • Antibodies
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Sources for Vitamin K Deficiency Hemorrhagic Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet