MCID: VTM001
MIFTS: 37

Vitamin K Deficiency Hemorrhagic Disease malady

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Summaries for Vitamin K Deficiency Hemorrhagic Disease

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34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to warfarin resistance and vitamin k-dependent coagulation defect. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinol biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds Vitamin K1 2,3-epoxide and vitamin k hydroquinone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are mortality/aging and cardiovascular system.

Wikipedia:65 Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body needs for... more...

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

vitamin k deficiency hemorrhagic disease 8 10
vitamin k deficiency 8 45 62
deficiency of vitamin k 8
vitamin k 34


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Disease Ontology8 DOID:11249
MeSH35 D014813
SNOMED-CT58 124892003, 52675005
ICD9CM27 269.0
ICD1025 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

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17GeneCards, 18GeneDecks
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Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1warfarin resistance31.0VKORC1
2vitamin k-dependent coagulation defect30.8GGCX
3thromboembolism30.7F2, F3, F7
4hemorrhagic disease30.7F2, F3
5pseudoxanthoma elasticum30.4MGP, GGCX
6lupus erythematosus30.1F2, F3
7disseminated intravascular coagulation30.1F2, F3, F7
8atherosclerosis30.1MGP, F3, VKORC1, F7
9protein s deficiency30.0F2, F3
10pulmonary embolism30.0F3, F2
11antiphospholipid syndrome30.0F3, F2
12venous thrombosis30.0F3, F2
13hemophilia b30.0F7, F3, F2
14thrombocytopenia30.0F7, F3, F2
15hepatocellular carcinoma10.6
16prothrombin deficiency10.5
17warfarin sensitivity10.5
18venous thromboembolism10.5
19vitamin k-dependent clotting factors, combined deficiency of, 210.4
20biliary atresia10.4
21chondrodysplasia10.4
22hereditary resistance to anti-vitamin k10.3
23vitamin k-dependent clotting factors, combined deficiency of, 110.3
24cystic fibrosis10.3
25liver disease10.3
26kidney disease10.3
27bone fracture10.2
28hepatitis b10.2
29aortic atherosclerosis10.2
30calciphylaxis10.2
31protein c deficiency10.2
32hepatitis10.2
33pancreatitis10.2
34retinal vein occlusion10.2
35retinitis10.2
36tuberculosis10.2
37uremia10.2
38abetalipoproteinemia10.1
39diabetes insipidus10.1
40celiac disease10.1
41choledochal cyst10.1
42hemarthrosis10.1
43hemolytic-uremic syndrome10.1
44systemic lupus erythematosus10.1
45parkinson's disease10.1
46binder syndrome10.1
47cervicitis10.1
48cholestasis10.1
49osteoporosis10.1
50paraplegia10.1

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Symptoms for Vitamin K Deficiency Hemorrhagic Disease

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Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Vitamin K Deficiency Hemorrhagic Disease

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

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Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

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33MalaCards
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MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

33
Bone

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8F7, GGCX, F3, MGP, F2
2MP:00053857.5F2, MGP, F3, GGCX, F7
3MP:00053767.3F7, GGCX, VKORC1, F3, MGP, F2

Publications for Vitamin K Deficiency Hemorrhagic Disease

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Variations for Vitamin K Deficiency Hemorrhagic Disease

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Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 54R&D Systems, 51PharmGKB
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Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
ubiquinol-10 biosynthesis (eukaryotic)38
all-trans-decaprenyl diphosphate biosynthesis38
9.6GGCX, VKORC1
29.4MGP, BGLAP
3
Show member pathways
thioredoxin pathway38
9.4F7, F2
4
Show member pathways
8.6F7, F3, F2
5
Show member pathways
8.6F2, F3, F7
6
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.6F7, F3, F2
7
Show member pathways
8.6F2, F3, F7
8
Show member pathways
8.6F7, GGCX, VKORC1, F2
9
Show member pathways
7.6F7, GGCX, VKORC1, BGLAP, MGP, F2

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources:
24HMDB, 45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1Vitamin K1 2,3-epoxide2410.1VKORC1, GGCX
2vitamin k hydroquinone4510.1GGCX, VKORC1
3fluindione51 4510.9F2, VKORC1
4r-warfarin459.8F2, VKORC1
5calcium oxalate459.8F2, GGCX
6aprosulate459.6F2, F3
7napsagatran459.6F2, F3
8brodifacoum459.5F2, F3
9mnpt459.5F3, F2
10certoparin459.5F2, F3
11appt459.5F2, F3
12hemochron459.5F2, F3
13heparin sodium459.5F2, F3
14inogatran459.5F2, F3
15ecarin459.5F3, F2
16dextran 70459.5F3, F2
17polybrene459.5F2, F3
18spectrozyme459.5F2, F3
19s-warfarin459.5F2, F3
20danaparoid459.5F2, F3
21hepaplastin459.5F2, F3
22rivaroxaban45 1110.4F2, F3
23kaolin459.4F2, F3
24ximelagatran45 1110.4F2, F3
25organon459.4F2, F3
26heparinoids459.4F3, F2
27fondaparinux459.4F3, F2
28bivalirudin45 1110.3F2, F3
29hydroxyethyl starch459.3F2, F3
30argatroban45 1110.2F2, F3
31ppack459.2F3, F2
32vitamin k2459.2GGCX, BGLAP
33tranexamic acid45 1110.1F2, F3
34acenocoumarol45 51 1111.1F2, F3, VKORC1
35phenprocoumon45 51 1111.1VKORC1, F3, F2
36coumarin45 3 51 2412.1F2, F3, VKORC1
37levonorgestrel45 61 29 1112.0F7, F3, F2
38protamine sulfate459.0F2, F3
39kininogen459.0F7, F3, F2
40vitamin k epoxide458.9F2, BGLAP, VKORC1, GGCX
41calcitriol45 61 24 1111.9BGLAP, MGP, F2
42simvastatin45 51 61 29 24 1113.7F2, BGLAP, F3
43coumarins458.5VKORC1, F3, BGLAP, F2
44menadione45 24 1110.4F2, BGLAP, VKORC1, GGCX, F7
45creatinine458.3F7, F3, BGLAP, F2
46aspartate458.3F2, BGLAP, F3, F7
47vitamin k145 249.1VKORC1, F3, BGLAP, MGP, F2
48serine457.8F7, F3, BGLAP, MGP, F2
49warfarin45 51 24 1110.2F7, GGCX, VKORC1, F3, BGLAP, MGP
50gamma-carboxyglutamic acid457.2BGLAP, MGP, F2, F3, VKORC1, F7

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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16Gene Ontology
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Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.4F7, F2
2extracellular spaceGO:0056157.7F7, F3, BGLAP, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:0325719.6BGLAP, F7
2positive regulation of blood coagulationGO:0301949.4F2, F7
3regulation of bone mineralizationGO:0305009.3BGLAP, MGP
4positive regulation of platelet-derived growth factor receptor signaling pathwayGO:0106419.3F3, F7
5blood coagulation, extrinsic pathwayGO:0075989.3F7, F3
6positive regulation of positive chemotaxisGO:0509279.2F7, F3
7positive regulation of protein kinase B signalingGO:0518979.1F7, F3
8response to estrogenGO:0436279.0F7, BGLAP
9peptidyl-glutamic acid carboxylationGO:0171878.9F7, GGCX, VKORC1, F2
10post-translational protein modificationGO:0436878.8F2, VKORC1, GGCX, F7
11cellular protein metabolic processGO:0442678.7F7, GGCX, VKORC1, F2
12blood coagulationGO:0075968.4F2, F3, GGCX, F7

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:0081479.1BGLAP, MGP
2calcium ion bindingGO:0055098.4F7, BGLAP, MGP, F2

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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  • Antibodies
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Sources for Vitamin K Deficiency Hemorrhagic Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet