MCID: VTM001
MIFTS: 34

Vitamin K Deficiency Hemorrhagic Disease malady

Categories: Metabolic diseases

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

Aliases & Descriptions for Vitamin K Deficiency Hemorrhagic Disease:

Name: Vitamin K Deficiency Hemorrhagic Disease 12 14
Vitamin K Deficiency 12 52 42 69
Deficiency of Vitamin K 12
Vitamin K 41

Classifications:



External Ids:

Disease Ontology 12 DOID:11249
ICD10 33 E56.1
ICD9CM 35 269.0
MeSH 42 D014813
NCIt 47 C99108
SNOMED-CT 64 124892003 52675005
UMLS 69 C0042880

Summaries for Vitamin K Deficiency Hemorrhagic Disease

MedlinePlus : 41 vitamins are substances that your body needs to grow and develop normally. vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards based summary : Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to hereditary combined deficiency of vitamin k-dependent clotting factors and chondrodysplasia punctata, autosomal dominant chondrodysplasia punctata due to vitamin k deficiency, included. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Benzocaine and Cholecalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 hereditary combined deficiency of vitamin k-dependent clotting factors 12.2
2 chondrodysplasia punctata, autosomal dominant chondrodysplasia punctata due to vitamin k deficiency, included 12.0
3 vitamin k-dependent clotting factors, combined deficiency of, 1 11.8
4 vitamin k-dependent clotting factors, combined deficiency of, 2 11.7
5 congenital disorder of glycosylation, type iil 11.0
6 factor x deficiency 11.0
7 chondrodysplasia punctata, x-linked dominant 11.0
8 rectum leiomyoma 10.2 AFP F2
9 chromosomal disease 10.2 BGLAP F2
10 angelucci's syndrome 10.2 AFP F2
11 freiberg's disease 10.2 F2 F8
12 alpha-2-macroglobulin deficiency 10.2 F2 F8
13 dyskinetic cerebral palsy 10.2 F2 F8
14 stroke, ischemic 10.2 F2 F8
15 dysgammaglobulinemia 10.2 AFP F2
16 autonomic neuropathy 10.2 F2 F8
17 bullous skin disease 10.2 F2 F8
18 fletcher factor deficiency 10.2 F2 F8
19 neuroaxonal dystrophy 10.2 F2 F8
20 lynch syndrome 10.2 F2 F8
21 capillary hemangioma 10.2 AFP F2
22 pineal region meningioma 10.2 BGLAP F8
23 myotonic dystrophy 10.2 F2 F8
24 essential thrombocythemia 10.2 F2 F8
25 infiltrating ureter transitional cell carcinoma 10.2 F2 F8
26 spinocerebellar ataxia 27 10.2 F2 F8
27 scapuloperoneal myopathy, x-linked dominant 10.1 F2 F8
28 mixed epithelial tumor of ovary 10.1 F2 PROS1
29 hendra virus infection 10.1 F2 PROS1
30 hemolytic-uremic syndrome 10.1 AFP F2
31 pregnancy loss, recurrent 2 10.1 F2 F8
32 low anorectal malformation 10.1 F2 F8
33 otopalatodigital syndrome, type i 10.1 F2 F8
34 scar contracture 10.1 F2 VKORC1
35 blepharoconjunctivitis 10.1 F2 PROS1
36 atrophic nonflaccid tympanic membrane 10.1 F2 F8
37 vulvitis 10.1 AFP F2
38 pregnancy loss, recurrent 1 10.1 F2 F8
39 aids dementia complex 10.1 F2 F8
40 pancreas adenocarcinoma 10.1 BGLAP F2
41 familial periodic paralysis 10.0 F2 VKORC1
42 focal epithelial hyperplasia 10.0 AFP F8
43 immunodeficiency, common variable, 6 10.0 F2 F8
44 unclassified intestinal pseudoobstruction 10.0 GGCX VKORC1
45 ocular hyperemia 10.0 F2 F8
46 giant papillary conjunctivitis 9.9 F2 F8 PROS1
47 pyridoxamine 5'-phosphate oxidase deficiency 9.9 F2 F8
48 arterial calcification, generalized, of infancy, 2 9.8 GGCX MGP VKORC1
49 alcoholic gastritis 9.8 AFP F2 F8 PROS1
50 social phobia 8.9 AFP BGLAP F2 F8 GGCX MGP

Comorbidity relations with Vitamin K Deficiency Hemorrhagic Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to Vitamin K Deficiency Hemorrhagic Disease

Symptoms & Phenotypes for Vitamin K Deficiency Hemorrhagic Disease

MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 AFP F2 F8 GGCX MGP PROS1
2 mortality/aging MP:0010768 9.17 AFP F2 F8 GGCX MGP PROS1

Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

Drugs for Vitamin K Deficiency Hemorrhagic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1 67-97-0 6221 10883523 5280795
3
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 50-14-6 5280793
4 tannic acid Approved, Nutraceutical Phase 4
5
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
6
Menadione Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-27-5 4055
7
Phytonadione Approved, Nutraceutical Phase 4,Phase 3,Phase 2 84-80-0 4812 5284607
8 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Calcium, Dietary Phase 4,Phase 3,Phase 2
10 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1
11 Hormones Phase 4,Phase 3
12 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
13 Retinol palmitate Phase 4
14 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
15 vitamin d Phase 4,Phase 3,Phase 2,Phase 1
16 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
17 Anticoagulants Phase 4,Phase 3
18 Antifibrinolytic Agents Phase 4,Phase 3,Phase 2
19 Coagulants Phase 4,Phase 3,Phase 2
20 Hemostatics Phase 4,Phase 3,Phase 2
21 Vitamin K 2 Phase 4,Phase 3,Phase 2
22 Vitamin MK 7 Phase 4,Phase 3,Phase 2
23 Thrombin Phase 4,Phase 3
24 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
25 retinol Nutraceutical Phase 4
26 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
27 Menaquinone Nutraceutical Phase 4,Phase 3,Phase 2
28 naphthoquinone Nutraceutical Phase 4,Phase 3,Phase 2
29 Vitamin K Nutraceutical Phase 4,Phase 3,Phase 2
30
Calcium carbonate Approved Phase 3,Phase 2 471-34-1
31
Zinc Approved Phase 3 7440-66-6 32051 23994
32
Selenium Approved, Vet_approved Phase 3 7782-49-2
33
Hydroxocobalamin Approved Phase 2, Phase 3 13422-51-0 11953898 5460373 44475014
34
Bevacizumab Approved, Investigational Phase 3 216974-75-3
35
Fluorouracil Approved Phase 3 51-21-8 3385
36
Levoleucovorin Approved Phase 3 68538-85-2
37
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599, 9887054 43805
38
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
39
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
41
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
42
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
43
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
44
Cyanocobalamin Approved, Nutraceutical Phase 2, Phase 3 68-19-9 44176380
45 Antacids Phase 3,Phase 2
46 Anti-Ulcer Agents Phase 3,Phase 2
47 Carotenoids Phase 3
48 Gastrointestinal Agents Phase 3,Phase 2
49 Tocopherols Phase 3
50 Tocotrienols Phase 3

Interventional clinical trials:

(show top 50) (show all 64)
id Name Status NCT ID Phase
1 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4
2 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4
3 Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal Completed NCT01159210 Phase 4
4 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4
5 Effect of Vitamin D Supplementation on Fasting Glucose and Interleukin-10 (IL-10) in Arab Women With Impaired Fasting Glucose Completed NCT00877123 Phase 4
6 Clinical Effects of Vitamin D Repletion in Patients With Parkinson's Disease Terminated NCT00571285 Phase 4
7 Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients Completed NCT01407601 Phase 3
8 Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Completed NCT00183001 Phase 3
9 Prothrombin Complex Concentrate for Anticoagulant Reversal Completed NCT00168077 Phase 3
10 The Effects of Vitamin D Repletion in Vitamin D Deficient Patients With Stage 3 and 4 Chronic Kidney Disease Completed NCT01029002 Phase 3
11 Combined Vitamins and Minerals Decrease Incidence of Upper Respiratory Tract Infections in Older Persons Completed NCT01484756 Phase 3
12 Role of Antioxidants Supplementation in Chronic Pancreatitis Completed NCT00319358 Phase 3
13 Vitamin B12 Supplementation During Pregnancy on Cognitive Development Recruiting NCT03071666 Phase 2, Phase 3
14 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3
15 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Not yet recruiting NCT02473341 Phase 3
16 Vitamin D as a Modifier of Serum Hepcidin in Children With Chronic Kidney Disease Unknown status NCT01532349 Phase 2
17 Vitamin K2 Supplementation and Arterial Stiffness in the Renal Transplant Population (The KING Trial) Completed NCT02517580 Phase 2
18 Effect of Vitamin D Supplementation on Hemoglobin A1c Completed NCT01354262 Phase 2
19 VitamIN D Treating patIents With Chronic heArT failurE Completed NCT01619891 Phase 2
20 Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents Completed NCT01102374 Phase 2
21 A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Completed NCT00000655 Phase 2
22 Safety and Effectiveness of Alendronate for Bone Mineral Density in HIV-infected Children and Adolescents Completed NCT00921557 Phase 2
23 Treatment to Reduce Vascular Calcification In Hemodialysis Patients Using Vitamin K Recruiting NCT02870829 Phase 2
24 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Not yet recruiting NCT02974257 Phase 2
25 Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus Terminated NCT01498406 Phase 2
26 A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis Completed NCT00461448 Phase 1
27 Defining Vitamin D Insufficiency in School Age Children: A Randomized Placebo Controlled Trial of Vitamin D3 Completed NCT00732758 Phase 1
28 Magnesium Supplementation to Prevent Bone Loss Completed NCT00346658 Phase 1
29 Nutritional Status of Patients Victims of Haemorragic Accidents With Antivitamins K Unknown status NCT01742871
30 The Effect of Vitamin D on Lung Function in Patients With Cystic Fibrosis Unknown status NCT02043717
31 Complications After Bariatric Surgery - a Clinical Trial Unknown status NCT01930838
32 The Cork BASELINE Birth Cohort Study Unknown status NCT01498965
33 D Vitamin Intervention in VA Completed NCT01375660
34 Changes in Microbiota and Iron Status After Iron Fortification of Complementary Foods Completed NCT01111864
35 Improving Vitamin D Status in Home-bound Elders Completed NCT01410084
36 Identifying Vitamin D Deficiency in Very Low Birth Weight Infant (VLBW) Infants Part 2 Completed NCT01363167
37 Vitamin D Deficiency, Insulin Resistance and FGF-23 Completed NCT00491322
38 The Association Between Religious Origin and Age, and Vitamin B12 and Folic Acid Plasma Levels in Non Jewish Population in Western Galilee Completed NCT01297361
39 Different Vitamin D Preparations & FGF23 in Humans Completed NCT00957879
40 Role of Vitamin D in Innate Immunity to Tuberculosis Completed NCT01244204
41 Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function Completed NCT02392767
42 Vitamin D and Arterial Function in Patients With Chronic Kidney Disease Completed NCT01384539
43 Effect of Vitamin D Supplementation on Oral Glucose Tolerance Among Obese Adolescents Completed NCT01856946
44 Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children Completed NCT00272116
45 A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial Completed NCT00374023
46 Efficacy and Safety Study of Oral Eligen® B12 in Subjects With Low Serum Cobalamin Completed NCT01312831
47 A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Completed NCT00001994
48 Project Grow Smart: Intervention Trial of Multiple Micronutrients and Early Learning Among Infants in India Completed NCT01660958
49 Treatment of Hypovitaminosis D in Rheumatoid Arthritis Completed NCT00423358
50 Impact of Zinc Supplementation on Mortality and Hospitalizations in Children Aged 1 Months to 23 Months Completed NCT00269542

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Cochrane evidence based reviews: vitamin k deficiency

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

39
Bone

Publications for Vitamin K Deficiency Hemorrhagic Disease

Variations for Vitamin K Deficiency Hemorrhagic Disease

Expression for Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for Vitamin K Deficiency Hemorrhagic Disease

Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.64 F2 F8 PROS1
2 11.47 F2 F8 PROS1
3 11.35 AFP BGLAP
4
Show member pathways
11.29 BGLAP F2 GGCX PROS1
5 11.05 AFP F2
6 10.9 BGLAP MGP
7
Show member pathways
10.68 GGCX VKORC1
8 10.28 BGLAP F2 GGCX MGP PROS1 VKORC1

GO Terms for Vitamin K Deficiency Hemorrhagic Disease

Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 AFP BGLAP F2 F8 PROS1
2 extracellular region GO:0005576 9.63 AFP BGLAP F2 F8 MGP PROS1
3 platelet alpha granule lumen GO:0031093 9.32 F8 PROS1
4 Golgi lumen GO:0005796 9.13 BGLAP F2 PROS1
5 endoplasmic reticulum lumen GO:0005788 8.92 AFP BGLAP F2 F8

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.56 BGLAP F2 F8 PROS1
2 hemostasis GO:0007599 9.5 F2 F8 PROS1
3 bone development GO:0060348 9.48 BGLAP VKORC1
4 acute-phase response GO:0006953 9.46 F2 F8
5 fibrinolysis GO:0042730 9.43 F2 PROS1
6 regulation of bone mineralization GO:0030500 9.4 BGLAP MGP
7 blood coagulation, intrinsic pathway GO:0007597 9.37 F2 F8
8 blood coagulation GO:0007596 9.35 F2 F8 GGCX PROS1 VKORC1
9 signal peptide processing GO:0006465 9.33 BGLAP F2 PROS1
10 peptidyl-glutamic acid carboxylation GO:0017187 9.02 BGLAP F2 GGCX PROS1 VKORC1

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 BGLAP F2 MGP PROS1
2 structural constituent of bone GO:0008147 8.62 BGLAP MGP

Sources for Vitamin K Deficiency Hemorrhagic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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