MCID: VTM001
MIFTS: 32

Vitamin K Deficiency Hemorrhagic Disease malady

Metabolic diseases category

Summaries for Vitamin K Deficiency Hemorrhagic Disease

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MedlinePlus:32 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards based summary: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to vitamin k-dependent clotting factors, combined deficiency of, 1 and pseudoxanthoma elasticum. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinol biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds Vitamin K1 2,3-epoxide and vitamin k hydroquinone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are mortality/aging and cardiovascular system.

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

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Vitamin K Deficiency Hemorrhagic Disease, Aliases & Descriptions:

Name: Vitamin K Deficiency Hemorrhagic Disease 9 11
Vitamin K Deficiency 9 43 60
Vitamin K Deficiency Coagulation Disorder 60
 
Deficiency of Vitamin K 9
Vitamin K 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:11249
MeSH33 D014813
SNOMED-CT55 124892003, 52675005
ICD9CM27 269.0
ICD1025 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

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Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1vitamin k-dependent clotting factors, combined deficiency of, 131.2GGCX
2pseudoxanthoma elasticum30.7MGP, GGCX
3hemorrhagic disease30.7F2, F3
4liver disease30.2F7, F3, F2
5protein s deficiency30.1F2, F3
6pulmonary embolism30.1F3, F2
7antiphospholipid syndrome30.0F3, F2
8disseminated intravascular coagulation30.0F2, F3, F7
9lupus erythematosus30.0F2, F3
10hemophilia b29.8F7, F3, F2
11thrombocytopenia29.8F7, F3, F2
12atherosclerosis29.8MGP, F3, VKORC1, F7
13hypoprothrombinemia10.8
14inherited hypoprothrombinemia10.8
15prothrombin deficiency10.7
16hepatocellular carcinoma10.6
17hereditary combined deficiency of vitamin k-dependent clotting factors10.6
18vitamin k-dependent clotting factors, combined deficiency of, 210.5
19coumarin resistance10.4VKORC1
20biliary atresia10.4
21chondrodysplasia punctata10.4
22chondrodysplasia10.4
23glanzmann thrombasthenia10.4F7
24varicose veins10.4F2
25hereditary resistance to anti-vitamin k10.4
26resistance to vitamin k antagonists10.3
27cystic fibrosis10.3
28celiac disease10.3
29factor xiii deficiency10.3F3
30factor xii deficiency10.3F3
31calciphylaxis10.3
32kidney disease10.3
33vitamin k antagonists toxicity or dose selection10.3
34body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency10.3
35aortic atherosclerosis10.2
36bone fracture10.2
37hepatitis10.2
38hepatitis b10.2
39retinal vein occlusion10.2
40protein c deficiency10.2
41atrial fibrillation10.2
42pancreatitis10.2
43retinitis10.2
44tuberculosis10.2
45uremia10.2
46german syndrome10.2
47systemic lupus erythematosus10.2
48hypercholanemia, familial10.2
49abetalipoproteinemia10.2
50osteoporosis10.2

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Symptoms for Vitamin K Deficiency Hemorrhagic Disease

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Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

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Drug clinical trials:

Search ClinicalTrials for Vitamin K Deficiency Hemorrhagic Disease

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

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Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

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MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

31
Bone

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

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MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8F7, GGCX, F3, MGP, F2
2MP:00053857.5F2, MGP, F3, GGCX, F7
3MP:00053767.3F7, GGCX, VKORC1, F3, MGP, F2

Publications for Vitamin K Deficiency Hemorrhagic Disease

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Variations for Vitamin K Deficiency Hemorrhagic Disease

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Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
ubiquinol-10 biosynthesis (eukaryotic)36
all-trans-decaprenyl diphosphate biosynthesis36
9.6GGCX, VKORC1
29.4MGP, BGLAP
3
Show member pathways
thioredoxin pathway36
9.4F7, F2
4
Show member pathways
8.6F7, F3, F2
5
Show member pathways
8.6F2, F3, F7
6
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.6F7, F3, F2
7
Show member pathways
8.6F2, F3, F7
8
Show member pathways
8.6F7, GGCX, VKORC1, F2
9
Show member pathways
7.6F7, GGCX, VKORC1, BGLAP, MGP, F2

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1Vitamin K1 2,3-epoxide2410.1VKORC1, GGCX
2vitamin k hydroquinone4310.1GGCX, VKORC1
3fluindione49 4310.9F2, VKORC1
4r-warfarin439.8F2, VKORC1
5calcium oxalate439.8F2, GGCX
6aprosulate439.6F2, F3
7napsagatran439.6F2, F3
8brodifacoum439.5F2, F3
9mnpt439.5F3, F2
10certoparin439.5F2, F3
11appt439.5F2, F3
12hemochron439.5F2, F3
13heparin sodium439.5F2, F3
14inogatran439.5F2, F3
15ecarin439.5F3, F2
16dextran 70439.5F3, F2
17polybrene439.5F2, F3
18spectrozyme439.5F2, F3
19s-warfarin439.5F2, F3
20danaparoid439.5F2, F3
21hepaplastin439.5F2, F3
22rivaroxaban43 1210.4F2, F3
23kaolin439.4F2, F3
24ximelagatran43 1210.4F2, F3
25organon439.4F2, F3
26heparinoids439.4F3, F2
27fondaparinux439.4F3, F2
28bivalirudin43 1210.3F2, F3
29hydroxyethyl starch439.3F2, F3
30argatroban43 1210.2F2, F3
31ppack439.2F3, F2
32vitamin k2439.2GGCX, BGLAP
33tranexamic acid43 1210.1F2, F3
34acenocoumarol43 49 1211.1F2, F3, VKORC1
35phenprocoumon43 49 1211.1VKORC1, F3, F2
36coumarin43 2 49 2412.1F2, F3, VKORC1
37levonorgestrel43 59 28 1212.0F7, F3, F2
38protamine sulfate439.0F2, F3
39kininogen439.0F7, F3, F2
40vitamin k epoxide438.9F2, BGLAP, VKORC1, GGCX
41calcitriol43 59 24 1211.9BGLAP, MGP, F2
42simvastatin43 49 59 28 24 1213.7F2, BGLAP, F3
43coumarins438.5VKORC1, F3, BGLAP, F2
44menadione43 24 1210.4F2, BGLAP, VKORC1, GGCX, F7
45creatinine438.3F7, F3, BGLAP, F2
46aspartate438.3F2, BGLAP, F3, F7
47vitamin k143 249.1VKORC1, F3, BGLAP, MGP, F2
48serine437.8F7, F3, BGLAP, MGP, F2
49warfarin43 49 24 1210.2F7, GGCX, VKORC1, F3, BGLAP, MGP
50gamma-carboxyglutamic acid437.2BGLAP, MGP, F2, F3, VKORC1, F7

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.4F7, F2
2extracellular spaceGO:00056157.7F7, F3, BGLAP, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:00325719.6BGLAP, F7
2positive regulation of blood coagulationGO:00301949.4F2, F7
3regulation of bone mineralizationGO:00305009.3BGLAP, MGP
4positive regulation of platelet-derived growth factor receptor signaling pathwayGO:00106419.3F3, F7
5blood coagulation, extrinsic pathwayGO:00075989.3F7, F3
6positive regulation of positive chemotaxisGO:00509279.2F7, F3
7positive regulation of protein kinase B signalingGO:00518979.1F7, F3
8response to estrogenGO:00436279.0F7, BGLAP
9peptidyl-glutamic acid carboxylationGO:00171878.9F7, GGCX, VKORC1, F2
10post-translational protein modificationGO:00436878.8F2, VKORC1, GGCX, F7
11cellular protein metabolic processGO:00442678.7F7, GGCX, VKORC1, F2
12blood coagulationGO:00075968.4F2, F3, GGCX, F7

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:00081479.1BGLAP, MGP
2calcium ion bindingGO:00055098.4F7, BGLAP, MGP, F2

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources for Vitamin K Deficiency Hemorrhagic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet