MCID: VTM001
MIFTS: 37

Vitamin K Deficiency Hemorrhagic Disease malady

Metabolic diseases category

Summaries for Vitamin K Deficiency Hemorrhagic Disease

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MedlinePlus:34 Vitamin k helps your body by making proteins for healthy bones and tissues. it also makes proteins for blood clotting. if you don't have enough vitamin k, you may bleed too much. newborns have very little vitamin k. they usually get a shot of vitamin k soon after they are born. if you take blood thinners, you need to be careful about how much vitamin k you get. you also need to be careful about taking vitamin e supplements. vitamin e can interfere with how vitamin k works in your body. ask your health care provider for recommendations about these vitamins. there are different types of vitamin k. most people get vitamin k from plants such as green vegetables, and dark berries. bacteria in your intestines also produce small amounts of another type of vitamin k.

MalaCards based summary: Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to hemorrhagic disease and vitamin k-dependent clotting factors, combined deficiency of, 1. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is GGCX (gamma-glutamyl carboxylase), and among its related pathways are Ubiquinol biosynthesis and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds Vitamin K1 2,3-epoxide and vitamin k hydroquinone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are mortality/aging and cardiovascular system.

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

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Vitamin K Deficiency Hemorrhagic Disease, Aliases & Descriptions:

Name: Vitamin K Deficiency Hemorrhagic Disease 10 12
Vitamin K Deficiency 10 45 62
 
Deficiency of Vitamin K 10 62
Vitamin K 34


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology10 DOID:11249
MeSH35 D014813
SNOMED-CT57 124892003, 52675005
ICD9CM29 269.0
ICD1027 E56.1

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

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Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic disease30.7F2, F3
2vitamin k-dependent clotting factors, combined deficiency of, 130.6GGCX
3liver disease30.4F7, F3, F2
4pseudoxanthoma elasticum30.3MGP, GGCX
5atherosclerosis30.2MGP, F3, VKORC1, F7
6lupus erythematosus30.2F2, F3
7disseminated intravascular coagulation30.2F2, F3, F7
8protein s deficiency30.0F2, F3
9pulmonary embolism30.0F3, F2
10antiphospholipid syndrome30.0F3, F2
11hemophilia b30.0F7, F3, F2
12thrombocytopenia30.0F7, F3, F2
13hepatocellular carcinoma10.6
14prothrombin deficiency10.6
15hereditary combined deficiency of vitamin k-dependent clotting factors10.5
16vitamin k-dependent clotting factors, combined deficiency of, 210.5
17biliary atresia10.4
18chondrodysplasia punctata10.4
19chondrodysplasia10.4
20hereditary resistance to anti-vitamin k10.3
21cystic fibrosis10.3
22celiac disease10.3
23hypoprothrombinemia10.3
24calciphylaxis10.3
25kidney disease10.3
26resistance to vitamin k antagonists10.3
27aortic atherosclerosis10.2
28bone fracture10.2
29hepatitis10.2
30hepatitis b10.2
31retinal vein occlusion10.2
32protein c deficiency10.2
33atrial fibrillation10.2
34pancreatitis10.2
35retinitis10.2
36tuberculosis10.2
37uremia10.2
38german syndrome10.2
39vitamin k antagonists toxicity or dose selection10.2
40body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency10.2
41systemic lupus erythematosus10.2
42hypercholanemia, familial10.2
43abetalipoproteinemia10.2
44osteoporosis10.2
45chondrodysplasia punctata, x-linked dominant10.2
46diabetes insipidus10.2
47choledochal cyst10.2
48hemarthrosis10.2
49hemolytic-uremic syndrome10.2
50binder syndrome10.2

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to vitamin k deficiency hemorrhagic disease

Symptoms for Vitamin K Deficiency Hemorrhagic Disease

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Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

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Drug clinical trials:

Search ClinicalTrials for Vitamin K Deficiency Hemorrhagic Disease

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

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Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

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MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

33
Bone

Animal Models for Vitamin K Deficiency Hemorrhagic Disease or affiliated genes

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MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8F7, GGCX, F3, MGP, F2
2MP:00053857.5F2, MGP, F3, GGCX, F7
3MP:00053767.3F7, GGCX, VKORC1, F3, MGP, F2

Publications for Vitamin K Deficiency Hemorrhagic Disease

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Variations for Vitamin K Deficiency Hemorrhagic Disease

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Expression for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
ubiquinol-10 biosynthesis (eukaryotic)38
all-trans-decaprenyl diphosphate biosynthesis38
9.6GGCX, VKORC1
29.4MGP, BGLAP
3
Show member pathways
thioredoxin pathway38
9.4F7, F2
4
Show member pathways
8.6F7, F3, F2
5
Show member pathways
8.6F2, F3, F7
6
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.6F7, F3, F2
7
Show member pathways
8.6F2, F3, F7
8
Show member pathways
8.6F7, GGCX, VKORC1, F2
9
Show member pathways
7.6F7, GGCX, VKORC1, BGLAP, MGP, F2

Compounds for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Compounds related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1Vitamin K1 2,3-epoxide2610.1VKORC1, GGCX
2vitamin k hydroquinone4510.1GGCX, VKORC1
3fluindione51 4510.9F2, VKORC1
4r-warfarin459.8F2, VKORC1
5calcium oxalate459.8F2, GGCX
6aprosulate459.6F2, F3
7napsagatran459.6F2, F3
8brodifacoum459.5F2, F3
9mnpt459.5F3, F2
10certoparin459.5F2, F3
11appt459.5F2, F3
12hemochron459.5F2, F3
13heparin sodium459.5F2, F3
14inogatran459.5F2, F3
15ecarin459.5F3, F2
16dextran 70459.5F3, F2
17polybrene459.5F2, F3
18spectrozyme459.5F2, F3
19s-warfarin459.5F2, F3
20danaparoid459.5F2, F3
21hepaplastin459.5F2, F3
22rivaroxaban45 1310.4F2, F3
23kaolin459.4F2, F3
24ximelagatran45 1310.4F2, F3
25organon459.4F2, F3
26heparinoids459.4F3, F2
27fondaparinux459.4F3, F2
28bivalirudin45 1310.3F2, F3
29hydroxyethyl starch459.3F2, F3
30argatroban45 1310.2F2, F3
31ppack459.2F3, F2
32vitamin k2459.2GGCX, BGLAP
33tranexamic acid45 1310.1F2, F3
34acenocoumarol45 51 1311.1F2, F3, VKORC1
35phenprocoumon45 51 1311.1VKORC1, F3, F2
36coumarin45 3 51 2612.1F2, F3, VKORC1
37levonorgestrel45 61 30 1312.0F7, F3, F2
38protamine sulfate459.0F2, F3
39kininogen459.0F7, F3, F2
40vitamin k epoxide458.9F2, BGLAP, VKORC1, GGCX
41calcitriol45 61 26 1311.9BGLAP, MGP, F2
42simvastatin45 51 61 30 26 1313.7F2, BGLAP, F3
43coumarins458.5VKORC1, F3, BGLAP, F2
44menadione45 26 1310.4F2, BGLAP, VKORC1, GGCX, F7
45creatinine458.3F7, F3, BGLAP, F2
46aspartate458.3F2, BGLAP, F3, F7
47vitamin k145 269.1VKORC1, F3, BGLAP, MGP, F2
48serine457.8F7, F3, BGLAP, MGP, F2
49warfarin45 51 26 1310.2F7, GGCX, VKORC1, F3, BGLAP, MGP
50gamma-carboxyglutamic acid457.2BGLAP, MGP, F2, F3, VKORC1, F7

GO Terms for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.4F7, F2
2extracellular spaceGO:00056157.7F7, F3, BGLAP, F2

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin KGO:00325719.6BGLAP, F7
2positive regulation of blood coagulationGO:00301949.4F2, F7
3regulation of bone mineralizationGO:00305009.3BGLAP, MGP
4positive regulation of platelet-derived growth factor receptor signaling pathwayGO:00106419.3F3, F7
5blood coagulation, extrinsic pathwayGO:00075989.3F7, F3
6positive regulation of positive chemotaxisGO:00509279.2F7, F3
7positive regulation of protein kinase B signalingGO:00518979.1F7, F3
8response to estrogenGO:00436279.0F7, BGLAP
9peptidyl-glutamic acid carboxylationGO:00171878.9F7, GGCX, VKORC1, F2
10post-translational protein modificationGO:00436878.8F2, VKORC1, GGCX, F7
11cellular protein metabolic processGO:00442678.7F7, GGCX, VKORC1, F2
12blood coagulationGO:00075968.4F2, F3, GGCX, F7

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of boneGO:00081479.1BGLAP, MGP
2calcium ion bindingGO:00055098.4F7, BGLAP, MGP, F2

Products for genes affiliated with Vitamin K Deficiency Hemorrhagic Disease

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Sources for Vitamin K Deficiency Hemorrhagic Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet