MCID: VTM003
MIFTS: 30

Vitamin Metabolic Disorder malady

Categories: Metabolic diseases

Aliases & Classifications for Vitamin Metabolic Disorder

Aliases & Descriptions for Vitamin Metabolic Disorder:

Name: Vitamin Metabolic Disorder 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050718

Summaries for Vitamin Metabolic Disorder

Disease Ontology : 12 An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism.

MalaCards based summary : Vitamin Metabolic Disorder is related to cerebral folate receptor alpha deficiency and vitamin b12 deficiency. An important gene associated with Vitamin Metabolic Disorder is GIF (Gastric Intrinsic Factor), and among its related pathways/superpathways are Metabolism and HIV Life Cycle. The drugs Sevelamer and Iron have been mentioned in the context of this disorder. Related phenotype is Increased shRNA abundance.

Related Diseases for Vitamin Metabolic Disorder

Diseases related to Vitamin Metabolic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
id Related Disease Score Top Affiliating Genes
1 cerebral folate receptor alpha deficiency 10.7
2 vitamin b12 deficiency 10.7
3 methylmalonic aciduria and homocystinuria, cblc type 10.2 CBL MTR
4 myh7-related myosin storage myopathy 10.1 MTHFR MTR
5 homocystinuria due to mthfr deficiency 10.1 MTHFR MTR
6 deafness, autosomal recessive 45 10.1 MTHFR MTR
7 color blindness 10.1 GIF TCN1 TCN2
8 ezh2-related overgrowth 10.1 LMBRD1 MTR
9 houlston ironton temple syndrome 10.1 MTHFR MTR
10 autosomal dominant sideroblastic anemia 10.1 MTHFR MTR
11 hnrnpa1-related amyotrophic lateral sclerosis 10.1 MTHFR TCN2
12 rhabdomyosarcoma 10.1 MTR TCN2
13 myosclerosis, congenital 10.0 MTHFR MTR TCN2
14 nephronophthisis 16 10.0 AMN CUBN
15 calcaneonavicular coalition 10.0 MTR MUT TCN2
16 3-methylglutaconic aciduria 9.9 CD320 TCN2
17 borderline glaucoma 9.9 MTHFR MTR MUT
18 craniofaciofrontodigital syndrome 9.9 MTHFR MTR
19 hmg-coa synthase-2 deficiency 9.9 MTHFR MTR TCN2
20 autosomal recessive disease 9.9 AMN CBL CUBN GIF
21 diabetes mellitus, insulin-dependent, 4 9.9 AMN CBL CUBN GIF
22 cleft lip 9.8 LMBRD1 MTHFR MTR TCN2
23 cdkn2a-related cutaneous malignant melanoma 9.8 LMBRD1 MTR MUT TCN2
24 congenital intrinsic factor deficiency 9.8 GIF MTHFR MTR TCN1 TCN2
25 warburg micro syndrome 3 9.8 AMN CUBN MTHFR MTR
26 hyperekplexia 2, autosomal recessive 9.7 LMBRD1 MTHFR MTR MUT TCN2
27 vaginal glandular tumor 9.5 AMN CUBN GIF MTHFR MTR TCN2
28 agammaglobulinemia 2 9.0 CBL CUBN GIF LMBRD1 MTHFR MTR
29 coenzyme q10 deficiency disease 8.6 AMN CBL CD320 CUBN GIF LMBRD1

Graphical network of the top 20 diseases related to Vitamin Metabolic Disorder:



Diseases related to Vitamin Metabolic Disorder

Symptoms & Phenotypes for Vitamin Metabolic Disorder

GenomeRNAi Phenotypes related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CBL MTHFR MTR MUT

Drugs & Therapeutics for Vitamin Metabolic Disorder

Drugs for Vitamin Metabolic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 710)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevelamer Approved Phase 4,Phase 2 52757-95-6, 152751-57-0 3085017
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
3
Zinc Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 7440-66-6 32051 23994
4
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
5
Fenofibrate Approved Phase 4,Phase 2 49562-28-9 3339
6
Linagliptin Approved Phase 4,Phase 3 668270-12-0 10096344
7
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
8
Voglibose Approved, Investigational Phase 4,Phase 2,Phase 3 83480-29-9 444020
9
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3 111025-46-8 4829
10
Nicorandil Approved Phase 4 65141-46-0 47528
11
Etidronic acid Approved Phase 4,Phase 3 7414-83-7, 2809-21-4 3305
12
Alendronate Approved Phase 4,Phase 3,Phase 2,Phase 1 121268-17-5, 66376-36-1 2088
13
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2 52232-67-4 16133850
14
Calcium carbonate Approved Phase 4,Phase 3,Phase 2,Phase 1 471-34-1
15
Copper Approved Phase 4,Phase 3,Phase 2,Phase 1 15158-11-9, 7440-50-8 27099
16
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Phase 1 13422-51-0 11953898 5460373 44475014
17
Warfarin Approved Phase 4,Phase 3,Phase 1 81-81-2 6691 54678486
18
Vildagliptin Approved, Investigational Phase 4,Phase 2,Phase 3 274901-16-5 6918537
19
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
20
Selenium Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7782-49-2
21
Ethanol Approved Phase 4,Phase 3 64-17-5 702
22
Menthol Approved Phase 4,Phase 3,Phase 1,Early Phase 1 2216-51-5 16666
23
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
24
Zoledronic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 118072-93-8 68740
25
Altretamine Approved Phase 4 645-05-6 2123
26
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
27
Acetylcarnitine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 3040-38-8 1
28
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
29
Indapamide Approved Phase 4 26807-65-8 3702
30
Irbesartan Approved, Investigational Phase 4,Phase 2 138402-11-6 3749
31
Apixaban Approved Phase 4 503612-47-3 10182969
32
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
33
Ramipril Approved Phase 4,Phase 2 87333-19-5 5362129
34
Telmisartan Approved, Investigational Phase 4,Phase 3 144701-48-4 65999
35
Budesonide Approved Phase 4 51333-22-3 63006 5281004
36
Montelukast Approved Phase 4 158966-92-8 5281040
37
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
38
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
39
Insulin Glargine Approved Phase 4,Phase 3 160337-95-1
40
Mitiglinide Approved, Investigational Phase 4 145375-43-5 3047758
41
Colestipol Approved Phase 4 26658-42-4, 50925-79-6 62816
42
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Phase 1 163222-33-1 150311
43
Lactulose Approved Phase 4 4618-18-2 11333
44 Strontium ranelate Approved Phase 4 135459-87-9
45
Lovastatin Approved, Investigational Phase 4,Phase 3 75330-75-5 53232
46
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
47
Topiramate Approved Phase 4 97240-79-4 5284627
48
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
49
Methyltestosterone Approved Phase 4,Phase 2,Phase 1 58-18-4 6010
50
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 1 58-22-0 6013

Interventional clinical trials:

(show top 50) (show all 1359)
id Name Status NCT ID Phase
1 Vitamin D and Glucose Metabolism in Pediatrics Unknown status NCT01386736 Phase 4
2 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4
3 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4
4 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4
5 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4
6 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
7 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4
8 Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin. Unknown status NCT00404599 Phase 4
9 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4
10 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4
11 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
12 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4
13 Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose Plus Niacin in the Treatment of Mixed Hyperlipidemia Unknown status NCT01010516 Phase 4
14 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4
15 Pioglitazone Vs Placebo in Combination With Niacin Extended Release on Low HDL Unknown status NCT00300365 Phase 4
16 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4
17 Efficacy Study of Nicorandil on Neointima Unknown status NCT02328521 Phase 4
18 Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes Unknown status NCT01978405 Phase 4
19 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4
20 Effects of Omega-3 Fatty Acids on Bone and Frailty Unknown status NCT00634686 Phase 4
21 The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels Unknown status NCT01765010 Phase 4
22 To Evaluate the Efficacy and the Safety of Monthly Versus Weekly Oral Risedronate With Vitamin D in Compliance, Improvement of Vitamin D and BMD in Korean Postmenopausal Osteoporotic Women Unknown status NCT01904110 Phase 4
23 Osteoporosis and Dental Implant Unknown status NCT00727493 Phase 4
24 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4
25 Efficacy and Safety Study of Risedronate, Cholecalciferol Combination Tablet in Patients With Osteoporosis Unknown status NCT01675297 Phase 4
26 How Does Magnesium Status Influence Calcium Homeostasis? Completed NCT01593501 Phase 4
27 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4
28 Can Vitamin D Supplementation Prevent Type 2 Diabetes? Completed NCT02112721 Phase 4
29 Effects of EPA and Vitamin E on Leptin, Adiponectin and Enzymatic Antioxidants in Type 2 DM Completed NCT00817622 Phase 4
30 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4
31 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4
32 Effect of Vitamin D Supplementation on Muscle Mass and Function Completed NCT01199926 Phase 4
33 Role of Myo-inositol and D-chiro Inositol on the Ovaric and Metabolic Functions Completed NCT01626443 Phase 4
34 Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast® Completed NCT00668200 Phase 4
35 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4
36 Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes Completed NCT01390480 Phase 4
37 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4
38 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4
39 Vitamin D Supplementation for the Prevention of Cardiovascular Risk Completed NCT02020694 Phase 4
40 Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes Completed NCT02019186 Phase 4
41 The Effect of Vitamin D Supplementation in Type 2 Diabetes Completed NCT01854463 Phase 4
42 Vitamin D Supplementation in Patients With Diabetes Mellitus Type 2 Completed NCT01741181 Phase 4
43 Role of Calcium And Vitamin D In Nutritional Rickets And It's Management Completed NCT01578434 Phase 4
44 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4
45 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4
46 Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2 Completed NCT01497132 Phase 4
47 A Study on Oral Vitamin D Megadoses Completed NCT01067898 Phase 4
48 Vitamin D and Genetics in Nutritional Rickets Completed NCT00949832 Phase 4
49 Influence of Vitamin D Treatment on Multi-systemic Functions in Young Men With Vitamin D Deficiency Due to Work Conditions Completed NCT01016184 Phase 4
50 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4

Search NIH Clinical Center for Vitamin Metabolic Disorder

Genetic Tests for Vitamin Metabolic Disorder

Anatomical Context for Vitamin Metabolic Disorder

Publications for Vitamin Metabolic Disorder

Variations for Vitamin Metabolic Disorder

Expression for Vitamin Metabolic Disorder

Search GEO for disease gene expression data for Vitamin Metabolic Disorder.

Pathways for Vitamin Metabolic Disorder

Pathways related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 AMN CD320 CUBN GIF LMBRD1 MTHFR
2
Show member pathways
13.41 AMN CBL CD320 CUBN GIF MTR
3
Show member pathways
12.26 AMN CD320 CUBN GIF LMBRD1 MTHFR
4
Show member pathways
12.13 CUBN GIF MTHFR MTR MUT TCN1
5
Show member pathways
11.97 MTHFR MTR MUT
6
Show member pathways
11.78 MTHFR MTR TCN2
7
Show member pathways
11.68 AMN CD320 CUBN GIF MTR MUT
8 11 CUBN GIF LMBRD1 TCN2
9 10.62 AMN CD320 CUBN GIF LMBRD1 MTR
10
Show member pathways
10.39 AMN CUBN GIF

GO Terms for Vitamin Metabolic Disorder

Cellular components related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.5 AMN CUBN GIF
2 clathrin-coated pit GO:0005905 9.4 AMN CUBN
3 endocytic vesicle GO:0030139 9.37 AMN CUBN
4 endosome membrane GO:0010008 9.33 AMN CD320 CUBN
5 brush border membrane GO:0031526 9.26 AMN CUBN
6 endosome GO:0005768 9.26 AMN CUBN GIF TCN2
7 lysosomal lumen GO:0043202 8.8 CUBN GIF TCN2

Biological processes related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.85 AMN CUBN GIF LMBRD1 TCN1 TCN2
2 cobalamin metabolic process GO:0009235 9.61 AMN CD320 CUBN GIF LMBRD1 MTR
3 lipoprotein metabolic process GO:0042157 9.4 AMN CUBN
4 cobalt ion transport GO:0006824 9.33 GIF TCN1 TCN2
5 high-density lipoprotein particle clearance GO:0034384 9.32 AMN CUBN
6 homocysteine metabolic process GO:0050667 9.26 MTHFR MUT
7 cobalamin transport GO:0015889 9.17 AMN CD320 CUBN GIF LMBRD1 TCN1

Molecular functions related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cobalamin binding GO:0031419 9.23 CD320 CUBN GIF LMBRD1 MTR MUT
2 modified amino acid binding GO:0072341 9.16 MTHFR MUT
3 cobalamin transporter activity GO:0015235 8.96 CD320 LMBRD1

Sources for Vitamin Metabolic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....