MCID: VTM003
MIFTS: 31

Vitamin Metabolic Disorder

Categories: Metabolic diseases

Aliases & Classifications for Vitamin Metabolic Disorder

MalaCards integrated aliases for Vitamin Metabolic Disorder:

Name: Vitamin Metabolic Disorder 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050718

Summaries for Vitamin Metabolic Disorder

Disease Ontology : 12 An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism.

MalaCards based summary : Vitamin Metabolic Disorder is related to ataxia with isolated vitamin e deficiency and cerebral folate receptor alpha deficiency. An important gene associated with Vitamin Metabolic Disorder is GIF (Gastric Intrinsic Factor), and among its related pathways/superpathways are Metabolism and HIV Life Cycle. The drugs Sevelamer and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver.

Related Diseases for Vitamin Metabolic Disorder

Diseases related to Vitamin Metabolic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
id Related Disease Score Top Affiliating Genes
1 ataxia with isolated vitamin e deficiency 10.7
2 cerebral folate receptor alpha deficiency 10.7
3 vitamin b12 deficiency 10.7
4 factor v leiden thrombophilia 10.3 AMN MTR
5 homocystinuria due to mthfr deficiency 10.3 MTHFR MTR
6 embryonal rhabdomyosarcoma 10.3 MTR TCN2
7 hereditary nephrotic syndromes, autosomal dominant 10.3 MTHFR TCN2
8 neural tube defects, folate-sensitive 10.3 MTHFR MTR
9 color blindness 10.2 GIF TCN1 TCN2
10 homologous wasting disease 10.2 MTHFR MTR
11 mediastinum leiomyoma 10.1 GIF MTHFR
12 ectopic pregnancy 10.1 MTHFR MTR
13 ehlers-danlos syndrome, type viic 10.0 MTHFR MTR
14 coenzyme q10 deficiency, primary, 2 9.9 AMN CUBN
15 cd19-related common variable immune deficiency 9.9 MTR MUT TCN2
16 autosomal dominant sideroblastic anemia 9.9 CD320 MTHFR TCN2
17 body dysmorphic disorder 9.9 MMADHC MUT
18 bone marrow failure syndrome 2 9.8 AMN CUBN
19 congenital hypomyelination neuropathy 9.7 MTHFR MTR
20 homocystinuria 9.7 MTHFR MTR MUT
21 autosomal dominant disease 9.7 AMN CUBN GIF
22 neural tube defects 9.6 MTHFR MTR TCN2
23 primary cerebellar degeneration 9.5 MMADHC MTHFR MTR TCN2
24 methylmalonic aciduria and homocystinuria type cblg 9.4 GIF MTHFR MTR TCN1 TCN2
25 calcaneonavicular coalition 8.9 MMADHC MTHFR MTR MUT TCN2
26 agammaglobulinemia 2 8.3 GIF MMADHC MTHFR MTR MUT TCN1
27 vaginal glandular tumor 7.7 AMN CUBN GIF MMADHC MTHFR MTR
28 serine deficiency 6.2 AMN CD320 CUBN GIF MMADHC MTHFR

Graphical network of the top 20 diseases related to Vitamin Metabolic Disorder:



Diseases related to Vitamin Metabolic Disorder

Symptoms & Phenotypes for Vitamin Metabolic Disorder

Drugs & Therapeutics for Vitamin Metabolic Disorder

Drugs for Vitamin Metabolic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 514)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevelamer Approved Phase 4,Phase 3,Phase 2 52757-95-6, 152751-57-0 3085017
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
3
Zinc Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 7440-66-6 32051 23994
4
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
5
Fenofibrate Approved Phase 4,Phase 2 49562-28-9 3339
6
Calcium Carbonate Approved Phase 4,Phase 2,Phase 3,Phase 1 471-34-1
7
Copper Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-50-8 27099
8
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Phase 1 13422-51-0 11953898 5460373 44475014
9
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
10
Vildagliptin Approved, Investigational Phase 4,Phase 2,Phase 3 274901-16-5 6918537
11
Amlodipine Approved Phase 4,Phase 2,Phase 3,Phase 1 88150-42-9 2162
12
Zoledronic acid Approved Phase 4,Phase 1 118072-93-8 68740
13
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3 56-81-5 753
14
Altretamine Approved Phase 4 645-05-6 2123
15
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
16
Acetylcarnitine Approved, Investigational Phase 4,Phase 3,Phase 2 3040-38-8 1
17
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
18
Indapamide Approved Phase 4 26807-65-8 3702
19
Irbesartan Approved, Investigational Phase 4,Phase 2 138402-11-6 3749
20
Apixaban Approved Phase 4 503612-47-3 10182969
21
Warfarin Approved Phase 4,Phase 3,Phase 1 81-81-2 6691 54678486
22
Alendronate Approved Phase 4,Phase 2 121268-17-5, 66376-36-1 2088
23
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
24
Ramipril Approved Phase 4,Phase 2 87333-19-5 5362129
25
Telmisartan Approved, Investigational Phase 4,Phase 3,Phase 1 144701-48-4 65999
26
Budesonide Approved Phase 4 51333-22-3 63006 5281004
27
Montelukast Approved Phase 4 158966-92-8 5281040
28
Ezetimibe Approved Phase 4,Phase 1 163222-33-1 150311
29
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
30
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
31
Voglibose Approved, Investigational Phase 4,Phase 2,Phase 3 83480-29-9 444020
32
Insulin Glargine Approved Phase 4,Phase 3 160337-95-1
33
Mitiglinide Approved, Investigational Phase 4 145375-43-5 3047758
34
Colestipol Approved Phase 4 26658-42-4, 50925-79-6 62816
35
Lactulose Approved Phase 4 4618-18-2 11333
36 Strontium ranelate Approved Phase 4 135459-87-9
37
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3 111025-46-8 4829
38
Lovastatin Approved, Investigational Phase 4,Phase 2 75330-75-5 53232
39
Ethanol Approved Phase 4,Phase 3 64-17-5 702
40
Menthol Approved Phase 4,Phase 3,Phase 1 2216-51-5 16666
41
Saxagliptin Approved Phase 4 361442-04-8 11243969
42
Rivaroxaban Approved Phase 4 366789-02-8
43
Phenprocoumon Approved Phase 4 435-97-2 9908 54680692
44
Dalteparin Approved Phase 4 9005-49-6
45
Testosterone Approved, Investigational Phase 4 58-22-0 6013
46
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 2 58-93-5 3639
47
Denosumab Approved Phase 4,Phase 1 615258-40-7
48
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
49
Enalaprilat Approved Phase 4 76420-72-9 6917719
50
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 878)

id Name Status NCT ID Phase Drugs
1 Vitamin D and Glucose Metabolism in Pediatrics Unknown status NCT01386736 Phase 4 Vitamin D drops;Placebo drops
2 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
3 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4 Vitamin D3
4 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
5 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
6 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
7 The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency Unknown status NCT01991054 Phase 4
8 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
9 Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin. Unknown status NCT00404599 Phase 4 atrorvastatin 10mg;simvastatin 40mg
10 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
11 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4 Calcitriol;placebo
12 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
13 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4 Folic Acid
14 Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose Plus Niacin in the Treatment of Mixed Hyperlipidemia Unknown status NCT01010516 Phase 4 High-dose rosuvastatin;Statin plus fenofibrate;Statin plus niacin ER/laropiprant
15 How Does Magnesium Status Influence Calcium Homeostasis? Completed NCT01593501 Phase 4
16 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4 Menaquinone
17 Can Vitamin D Supplementation Prevent Type 2 Diabetes? Completed NCT02112721 Phase 4
18 Effects of EPA and Vitamin E on Leptin, Adiponectin and Enzymatic Antioxidants in Type 2 DM Completed NCT00817622 Phase 4
19 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
20 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
21 Effect of Vitamin D Supplementation on Muscle Mass and Function Completed NCT01199926 Phase 4 Placebo
22 Role of Myo-inositol and D-chiro Inositol on the Ovaric and Metabolic Functions Completed NCT01626443 Phase 4
23 Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast® Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
24 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4 Calcitriol (Rocaltrol®);Paricalcitol
25 Effect of SLC30A8 rs13266634 Genetic Polymorphism on Zinc Supplementation and Glycemic Control in Egyptian Patients With Type 2 Diabetes Mellitus Completed NCT03112382 Phase 4 zinc supplement plus vitamin A and E;vitamin A and E
26 Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes Completed NCT01390480 Phase 4 Cholecalciferol
27 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4 Vitamin D3;Vitamin D3
28 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4 L-ascorbic acid
29 Vitamin D Supplementation for the Prevention of Cardiovascular Risk Completed NCT02020694 Phase 4 Vitamin D;Placebo (for vitamin D)
30 Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes Completed NCT02019186 Phase 4
31 Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients Completed NCT02214563 Phase 4
32 The Effect of Vitamin D Supplementation in Type 2 Diabetes Completed NCT01854463 Phase 4 Vitamin D3;placebo
33 Vitamin D Supplementation in Patients With Diabetes Mellitus Type 2 Completed NCT01741181 Phase 4 Vitamin D supplementation;Placebo Pill
34 Role of Calcium And Vitamin D In Nutritional Rickets And It's Management Completed NCT01578434 Phase 4 Vitamin D;Calcium Carbonate;Vitamin D and Calcium
35 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4 25 OH vitamin D
36 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
37 Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2 Completed NCT01497132 Phase 4 Vitamin D3;Placebo
38 A Study on Oral Vitamin D Megadoses Completed NCT01067898 Phase 4
39 Vitamin D and Genetics in Nutritional Rickets Completed NCT00949832 Phase 4
40 Influence of Vitamin D Treatment on Multi-systemic Functions in Young Men With Vitamin D Deficiency Due to Work Conditions Completed NCT01016184 Phase 4
41 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
42 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4 Vitamin D
43 Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus Completed NCT01436916 Phase 4 oral cholecalciferol + life style counselling;placebo + life style counselling
44 Immune and Metabolic Effects of Vitamin D Supplementation in Healthy Humans Completed NCT01248442 Phase 4 Cholecalciferol;Placebo
45 Effect of Three Different Doses of Oral Cholecalciferol on 25-Hydroxyvitamin D Changes Among Epilepsy Patients With Hypovitaminosis D Completed NCT02890823 Phase 4 Cholecalciferol
46 Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation Completed NCT01675089 Phase 4 Zoledronic acid
47 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
48 Renal Denervation in Diabetic Nephropathy Completed NCT01588795 Phase 4 Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin
49 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
50 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)

Search NIH Clinical Center for Vitamin Metabolic Disorder

Genetic Tests for Vitamin Metabolic Disorder

Anatomical Context for Vitamin Metabolic Disorder

MalaCards organs/tissues related to Vitamin Metabolic Disorder:

39
Bone, Kidney, Liver, Endothelial, Heart, Ovary, Testes

Publications for Vitamin Metabolic Disorder

Variations for Vitamin Metabolic Disorder

Expression for Vitamin Metabolic Disorder

Search GEO for disease gene expression data for Vitamin Metabolic Disorder.

Pathways for Vitamin Metabolic Disorder

Pathways related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 AMN CD320 CUBN GIF MMADHC MTHFR
2
Show member pathways
13.34 AMN CD320 CUBN GIF MMADHC MTR
3
Show member pathways
12.46 AMN CD320 CUBN GIF MMADHC MTHFR
4
Show member pathways
11.93 MTHFR MTR MUT
5
Show member pathways
11.73 MTHFR MTR TCN2
6
Show member pathways
11.21 AMN CD320 CUBN GIF MMADHC MTR
7 10.95 AMN CD320 CUBN GIF MMADHC MTR
8 10.81 CUBN GIF TCN2

GO Terms for Vitamin Metabolic Disorder

Cellular components related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.54 AMN CUBN GIF
2 clathrin-coated pit GO:0005905 9.4 AMN CUBN
3 endosome membrane GO:0010008 9.33 AMN CD320 CUBN
4 endocytic vesicle GO:0030139 9.32 AMN CUBN
5 brush border membrane GO:0031526 9.26 AMN CUBN
6 endosome GO:0005768 9.26 AMN CUBN GIF TCN2
7 lysosomal lumen GO:0043202 8.8 CUBN GIF TCN2

Biological processes related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.85 AMN CUBN GIF TCN1 TCN2 TTPA
2 cobalamin metabolic process GO:0009235 9.61 AMN CD320 CUBN GIF MMADHC MTR
3 cobalt ion transport GO:0006824 9.33 GIF TCN1 TCN2
4 high-density lipoprotein particle clearance GO:0034384 9.32 AMN CUBN
5 homocysteine metabolic process GO:0050667 9.26 MTHFR MUT
6 cobalamin transport GO:0015889 9.1 AMN CD320 CUBN GIF TCN1 TCN2

Molecular functions related to Vitamin Metabolic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cobalamin binding GO:0031419 9.17 CD320 CUBN GIF MTR MUT TCN1
2 modified amino acid binding GO:0072341 8.96 MTHFR MUT

Sources for Vitamin Metabolic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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