MCID: VTL002
MIFTS: 59

Vitiligo malady

Skin category

Summaries for Vitiligo

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. as a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. the average age of onset is in the mid-20s. it is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. in the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. the exact cause of vitiligo is not known, but there are several different theories. there is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. the main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments). last updated: 11/20/2012

MalaCards: Vitiligo is related to thyroiditis and alopecia areata. An important gene associated with Vitiligo is MCHR1 (melanin-concentrating hormone receptor 1), and among its related pathways are Phenylalanine metabolism and Basal cell carcinoma. The drugs methoxsalen and trioxsalen and the compounds tyrosine and dopachrome have been mentioned in the context of this disorder. Affiliated tissues include thymus, retina and heart, and related mouse phenotypes are homeostasis/metabolism and integument.

Disease Ontology:8 An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.

MedlinePlus:34 Vitiligo causes white patches on your skin. it can also affect your eyes, mouth, and nose. it occurs when the cells that give your skin its color are destroyed. no one knows what destroys them. it is more common in people with autoimmune diseases, and it might run in families. it usually starts before age 40. the white patches are more common where your skin is exposed to the sun. in some cases, the patches spread. vitiligo can cause your hair to gray early. if you have dark skin, you may lose color inside your mouth. using sunscreen will help protect your skin, and cosmetics can cover up the patches. treatments for vitiligo include medicines, light therapy, and surgery. not every treatment is right for everyone. many have side effects. some take a long time. some do not always work. nih: national institute of arthritis and musculoskeletal and skin diseases

Genetics Home Reference:21 Vitiligo is a condition that causes patchy changes in skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-20s, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.

Wikipedia:64 Vitiligo /ˌvɪtɨˈlaɪɡoʊ/ is a condition that causes depigmentation of parts of the skin. It occurs... more...

Description from OMIM:47 193200

Aliases & Classifications for Vitiligo

Sources:
8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 47OMIM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

vitiligo 8 43 21 10 45 34 31 61


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Disease Ontology8 DOID:12306
ICD9CM27 709.01
NCIt40 C26915
SNOMED-CT57 156437000, 56727007
OMIM47 193200
MeSH35 D014820
ICD1025 L80

Related Diseases for Vitiligo

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vitiligo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.6PTPN22, CTLA4
2alopecia areata30.6AIRE
3autoimmune thyroiditis30.5CTLA4, AIRE, TYRP1, PTPN22
4vitiligo-associated multiple autoimmune disease susceptibility 130.3NLRP1, SLEV1
5vogt-koyanagi-harada disease30.3TYR
6microphthalmia30.2TYRP1, TYR, DCT, MLANA, PMEL
7graves' disease30.2CTLA4, DCT, AIRE, TYR, TYRP1, PTPN22
8amelanotic melanoma29.9DCT, TYR, TYRP1
9albinism29.9DCT, TYR, TYRP1
10systemic lupus erythematosus29.9CTLA4, C4B, TYR, PTPN22
11vaccinia29.7TYR
12thymoma29.7AIRE, CTLA4
13oculocutaneous albinism29.7TYRP1, TYR
14celiac disease29.7PTPN22, CTLA4
15alopecia10.5
16halo nevi10.3
17pernicious anemia10.3
18alopecia universalis10.2
19alopecia universalis onychodystrophy vitiligo10.2
20discoid lupus erythematosus10.2
21hepatitis c10.2
22piebaldism10.2
23lichen planus10.2
24atopic dermatitis10.2
25mycosis fungoides10.2
26n syndrome10.2
27hepatitis a10.2
28deafness vitiligo achalasia10.2
29basal cell carcinoma10.1
30twenty-nail dystrophy10.1
31bullous pemphigoid10.1
32pityriasis rubra pilaris10.1
33kaposi's sarcoma10.1
34arthritis10.1
35squamous cell carcinoma10.1
36lichen sclerosus10.1
37hypothyroidism, autoimmune10.1
38melanoma10.0PMEL, CAT, CTLA4, MLANA, DCT, TYR
39hypothyroidism10.0CTLA4, DCT, AIRE, TYR, TYRP1
40skin cancer10.0CAT, MLANA, TYR, TYRP1
41testicular cancer10.0PMEL, MLANA, TYR, TYRP1
42influenza10.0TYR, MLANA, PMEL
43juvenile xanthogranuloma10.0PMEL, MLANA, TYR
44addison's disease10.0PTPN22, AIRE, CTLA4
45hermansky-pudlak syndrome10.0TYRP1, TYR
46hypersensitivity reaction type ii disease10.0PTPN22, AIRE, CTLA4
47intraocular melanoma10.0TYR, MLANA, PMEL
48lymphopenia10.0PTPN22, CAT
49hyperthyroidism10.0CTLA4, LPO, PTPN22
50angiomyolipoma10.0TYR, MLANA, PMEL

Graphical network of the top 20 diseases related to Vitiligo:



Diseases related to vitiligo

Clinical Features for Vitiligo

Sources:
47OMIM
See all sources

Clinical features from OMIM:

193200

Drugs & Therapeutics for Vitiligo

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vitiligo

Drug clinical trials:

Search ClinicalTrials for Vitiligo

Search NIH Clinical Center for Vitiligo

Search CenterWatch for Vitiligo

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Vitiligo cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Vitiligo:
JACE
Embryonic/Adult Cultured Cells Related to Vitiligo:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Vitiligo

Anatomical Context for Vitiligo

Sources:
33MalaCards
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MalaCards organs/tissues related to Vitiligo:

33
Thymus, Retina, Heart, Liver, Thyroid, Skin, Nk cells, T cells, B cells, Fetal liver, Fetal thyroid

Animal Models for Vitiligo or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Vitiligo

Sources:
51PubMed
See all sources

Articles related to Vitiligo:

(show top 50)    (show all 880)
idTitleAuthorsYear
1
Vitiligo management strategy in Jeddah, Saudi Arabia as reported by dermatologists and experienced by patients. (23273274)
2014
2
The association between a single nucleotide polymorphism rs11966200 in MHC region and clinical features of generalized vitiligo in Chinese Han population. (23516070)
2013
3
Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. (22963656)
2013
4
Role of in vivo reflectance confocal microscopy in determining stability in vitiligo: a preliminary study. (24249892)
2013
5
NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1I^ processing via the NLRP1 inflammasome. (23382179)
2013
6
Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female. (24350017)
2013
7
Pentachrome vitiligo in a segmental pattern. (23458395)
2013
8
Relapse after methylprednisolone oral minipulse therapy in childhood vitiligo: a 12-month follow-up study. (23716799)
2013
9
Association study between nonsense polymorphism (rs2039381, Gln71Stop) of interferon-I/ and susceptibility to vitiligo in Korean population. (23802172)
2013
10
Microchimerism in vitiligo. (22835060)
2013
11
Impact of vitiligo on the health-related quality of life of 104 adult patients, using Dermatology Life Quality Index and stress score: first Egyptian report. (24126099)
2013
12
Association of ACE gene I/D polymorphism with vitiligo: a meta-analysis. (23325447)
2013
13
Annular elastolytic giant cell granuloma developing on lesions of vitiligo. (23113612)
2013
14
Coexistence of lip-tip vitiligo and disseminated discoid lupus erythematosus with hypothyroidism: Need for careful therapeutic approach. (23741668)
2013
15
WITHDRAWN: Comparision between 308-nm excimer laser and 308-nm excimer lamp in the treatment of vitiligo - a randomized self control study. (23713762)
2013
16
Dermatology life quality index scores in children with vitiligo: comparison with atopic dermatitis and healthy control subjects. (23278616)
2013
17
Non-segmental vitiligo and psoriasis comorbidity - a case-control study in Italian patients. (23441884)
2013
18
Over-expression of tumor necrosis factor-I+ in vitiligo lesions after narrow-band UVB therapy: an immunohistochemical study. (22832941)
2012
19
Assessment methods for the evaluation of vitiligo. (22416879)
2012
20
Classification of vitiligo: a challenging endeavor. (23237033)
2012
21
Comparison between autologous noncultured epidermal cell suspension and suction blister epidermal grafting in stable vitiligo: a randomized study. (22897617)
2012
22
Post-thymus transplant vitiligo in a child with Foxn1 deficiency]. (22721479)
2012
23
Immunological Basis of Melanoma-Associated Vitiligo-Like Depigmentation. (23146137)
2012
24
Error in Byline in: Measurement Properties of Outcome Measures for Vitiligo: A Systematic Review. (23165831)
2012
25
Measurement Properties of Outcome Measures for Vitiligo: A Systematic Review. (22986764)
2012
26
Treatment of vitiligo: advantages and disadvantages, indications for use and outcomes. (21956273)
2011
27
Surgical excision and primary closure for the treatment of lip vitiligo. (22279393)
2011
28
Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. (21839315)
2011
29
Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo. (21913803)
2011
30
The polymorphism of catalase T/C codon 389 in exon 9 and vitiligo susceptibility: a meta-analysis. (21054578)
2011
31
Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo. (22125590)
2011
32
Vitiligo iridis in patients with a history of smallpox infection. (20733557)
2010
33
Juvenile-onset hypopigmented mycosis fungoides mimicking vitiligo. (19706233)
2009
34
Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (19555430)
2009
35
HAIR-AN syndrome in a male adolescent with concomitant vitiligo. (19380681)
2009
36
Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients. (18337837)
2008
37
Autoimmune diseases and vitamin D receptor Apa-I polymorphism are associated with vitiligo in a small inbred Romanian community. (16710576)
2006
38
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
39
Chilblain lupus erythematosus mimicking acrofacial vitiligo. (17642933)
2003
40
Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor. (14632194)
2003
41
Inflammatory vitiligo in Vogt-Koyanagi-Harada disease. (11148490)
2001
42
Successful treatment of oxidative stress in vitiligo. (10393521)
1999
43
Vitiligo, psoralen, and melanogenesis: some observations and understanding. (8888309)
1996
44
Pityriasis rubra pilaris, lichen planus, alopecia universalis and vitiligo in a patient with chronic viral hepatitis C. (8186518)
1994
45
Culture of melanocytes obtained from normal and vitiligo subjects. (1309014)
1992
46
Guttate psoriasis and vitiligo: anatomic cohabitation. (2715422)
1989
47
Dermatitis herpetiformis and vitiligo. (3769556)
1986
48
Serum electrophoretic patterns in vitiligo, psoriasis and discoid lupus erythematosus. (757701)
1978
49
Iritis in patients with cutaneous melanoma and vitiligo. (718499)
1978
50
The treatment of alopecia universalis with methyl prednisolone (medrol); associated with vitiligo involving arms, forearms, neck, and thigh. (13648966)
1959

Genetic Variations for Vitiligo

Expression for genes affiliated with Vitiligo

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vitiligo

Search GEO for disease gene expression data for Vitiligo.

Pathways for genes affiliated with Vitiligo

Sources:
30KEGG, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Pathways related to Vitiligo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TYRP1, TYR, DCT
2
Hide members
10.7TYRP1, TYR, DCT
3
Hide members
10.7PTPN22, CD8A, CTLA4
4
Hide members
10.6CAT, TYRP1
510.6TYRP1, CAT

Compounds for genes affiliated with Vitiligo

Sources:
45Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Vitiligo according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.3CTLA4, LPO, DCT, AIRE, TYR, TYRP1
2dopachrome4511.1TYRP1, TYR, DCT, PMEL
3levodopa45 1112.1CAT, DCT, TYR, TYRP1
4dhica4511.1DCT, TYR, TYRP1
5copper45 2412.1CAT, DCT, TYR, TYRP1
6arbutin2 4512.1TYRP1, TYR, DCT
7dopaquinone45 2412.0DCT, TYR, TYRP1
8eumelanin4511.0TYRP1, TYR, DCT
9hemocyanin4511.0TYR, CTLA4, PMEL
10hmba4511.0TYRP1, TYR, DCT
11tetrahydrobiopterin45 11 2413.0CAT, TYR, PCBD1
12cysteine4511.0TYRP1, TYR, DCT, LPO, CTLA4, CAT
134-s-cysteaminylphenol4510.9CAT, TYR
14kojic acid4510.9TYR, TYRP1
15l-dopachrome45 2411.9DCT, TYR
16salicylhydroxamic acid4510.9LPO, CAT
175,6-dihydroxyindole45 2411.9TYR, DCT
18resorcinol4510.9LPO, TYR
19h2o24510.9CAT, LPO, TYR, TYRP1, PCBD1
20lecithin4510.9DCT, TYRP1
213-hydroxyanthranilic acid45 2411.9CAT, TYR
22dmpo4510.8CAT, LPO
23silver4510.8PMEL, DCT, TYRP1
24guaiacol45 2411.8LPO, CAT
25dihydrobiopterin45 2411.8PCBD1, TYR
26ibmx45 29 6012.7TYRP1, TYR, DCT
27azide4510.6LPO, CAT
28cyanide45 2411.5LPO, DCT
29trolox4510.3LPO, CAT

GO Terms for genes affiliated with Vitiligo

Sources:
16Gene Ontology
See all sources

Cellular components related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosome membraneGO:03316210.7TYRP1, TYR, DCT
2melanosomeGO:04247010.5TYRP1, TYR, DCT, MLANA, PMEL

Biological processes related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanin biosynthetic process from tyrosineGO:00658310.6TYR, DCT
2hydrogen peroxide catabolic processGO:04274410.6LPO, CAT
3melanin biosynthetic processGO:04243810.5TYRP1, PMEL
4melanosome organizationGO:03243810.3TYRP1, PMEL

Molecular functions related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3NLRP1, CTLA4, FBXO11, MLANA, AIRE, TYR
2copper ion bindingGO:00550710.6TYRP1, TYR, DCT
3protein homodimerization activityGO:04280310.5CAT, TYR, TYRP1, CD8A, FGFR1OP

Products for genes affiliated with Vitiligo

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vitiligo

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet