MCID: VTL002
MIFTS: 60

Vitiligo malady

Rare diseases, Skin diseases, Immune diseases categories

Summaries for Vitiligo

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Sources:
9Disease Ontology, 22Genetics Home Reference, 44NIH Rare Diseases, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. as a result, white patches appear on the skin in different parts of the body, and sometimesĀ also on both the mucous membranes and the retina. the average age of onset is in the mid-20s.Ā it is generally considered to be an autoimmune disorder, andĀ about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. in the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. the exact cause of vitiligo is not known, but there are several different theories. there is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. the main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments). last updated: 11/20/2012

MalaCards: Vitiligo is related to thyroiditis and melanoma. An important gene associated with Vitiligo is NLRP1 (NLR family, pyrin domain containing 1), and among its related pathways are Phenylalanine metabolism and superoxide radicals degradation. The drugs methoxsalen and trioxsalen and the compounds dhica and kojic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and thyroid, and related mouse phenotypes are pigmentation and liver/biliary system.

Disease Ontology:9 A hypersensitivity reaction type ii disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.

Genetics Home Reference:22 Vitiligo is a condition that causes patchy changes in skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-20s, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.

MedlinePlus:35 Vitiligo causes white patches on your skin. it can also affect your eyes, mouth, and nose. it occurs when the cells that give your skin its color are destroyed. no one knows what destroys them. it is more common in people with autoimmune diseases, and it might run in families. it usually starts before age 40. the white patches are more common where your skin is exposed to the sun. in some cases, the patches spread. vitiligo can cause your hair to gray early. if you have dark skin, you may lose color inside your mouth. using sunscreen will help protect your skin, and cosmetics can cover up the patches. treatments for vitiligo include medicines, light therapy, and surgery. not every treatment is right for everyone. many have side effects. some take a long time. some do not always work. nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia:66 Vitiligo /?v?t??la??o?/ is a condition that causes depigmentation of parts of the skin. It occurs when... more...

Description from OMIM:48 193200

Aliases & Classifications for Vitiligo

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9Disease Ontology, 44NIH Rare Diseases, 22Genetics Home Reference, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 28ICD9CM, 48OMIM, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases


Aliases & Descriptions:

vitiligo 9 44 22 11 46 35 32 63


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Disease Ontology9 DOID:12306
ICD9CM28 709.01
OMIM48 193200
SNOMED-CT59 156437000, 56727007
MeSH36 D014820
NCIt41 C26915
ICD1026 L80

Related Diseases for Vitiligo

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Vitiligo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.9CTLA4, PTPN22
2melanoma30.7CTLA4, CD8A, CAT, MCHR1, TYR, TYRP1
3autoimmune thyroiditis30.5CTLA4, PTPN22, TYRP1, AIRE
4vogt-koyanagi-harada disease30.5TYR
5hypothyroidism30.3AIRE, TYRP1, TYR, CTLA4
6hepatitis30.3AIRE, CAT, CTLA4
7graves' disease30.1AIRE, TYRP1, TYR, PTPN22, CTLA4
8amelanotic melanoma30.1TYR, TYRP1
9albinism30.1TYR, TYRP1
10myasthenia gravis30.0AIRE, CTLA4
11type 1 diabetes mellitus30.0AIRE, PTPN22, CTLA4
12systemic lupus erythematosus29.9C4B, CTLA4, PTPN22, TYR
13diabetes mellitus29.9AIRE, PTPN22, CAT, CTLA4
14oculocutaneous albinism29.9TYRP1, TYR
15autoimmune hepatitis29.7CTLA4, AIRE
16alopecia10.5
17psoriasis10.5
18alopecia areata10.5
19dermatitis10.4
20lupus erythematosus10.4
21halo nevi10.3
22pernicious anemia10.3
23alopecia universalis10.3
24discoid lupus erythematosus10.3
25lichen planus10.2
26piebaldism10.2
27alopecia universalis onychodystrophy vitiligo10.2
28vitiligo-associated multiple autoimmune disease susceptibility 110.2
29hepatitis c10.2
30microphthalmia10.2
31mycosis fungoides10.2
32dermatitis herpetiformis10.2
33scleroderma10.2
34deafness vitiligo achalasia10.2
35atopic dermatitis10.1
36basal cell carcinoma10.1
37skin disease10.1
38twenty-nail dystrophy10.1
39waardenburg's syndrome10.1TYRP1, TYR
40pityriasis rubra pilaris10.1
41arthritis10.1
42rheumatoid arthritis10.1
43sarcoma10.1
44lichen sclerosus10.1
45blindness10.1
46ocular albinism10.1TYR, TYRP1
47hermansky-pudlak syndrome10.1TYR, TYRP1
48wegener's granulomatosis10.1CTLA4
49factor vii deficiency10.0CTLA4, TYR
50phenylketonuria10.0PCBD1, QDPR

Graphical network of the top 20 diseases related to Vitiligo:



Diseases related to vitiligo

Symptoms for Vitiligo

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48OMIM
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Clinical features from OMIM:

193200

Drugs & Therapeutics for Vitiligo

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Vitiligo

Drug clinical trials:

Search ClinicalTrials for Vitiligo

Search NIH Clinical Center for Vitiligo

Search CenterWatch for Vitiligo

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Vitiligo cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Vitiligo:
JACE
Embryonic/Adult Cultured Cells Related to Vitiligo:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Vitiligo

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Anatomical Context for Vitiligo

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34MalaCards
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MalaCards organs/tissues related to Vitiligo:

34
Skin, Eye, Thyroid, Retina, T cells, Testes, Liver, Heart, Thymus, Bone, B cells

Animal Models for Vitiligo or affiliated genes

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38MGI
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Publications for Vitiligo

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53PubMed
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Articles related to Vitiligo:

(show top 50)    (show all 868)
idTitleAuthorsYear
1
BB-UVA vs. NB-UVB in the treatment of vitiligo: a randomized controlled clinical study (single blinded). (24001379)
2013
2
The association between a single nucleotide polymorphism rs11966200 in MHC region and clinical features of generalized vitiligo in Chinese Han population. (23516070)
2013
3
Autoimmune thyroid disease in vitiligo: multivariate analysis indicates intricate pathomechanisms. (23253044)
2013
4
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
5
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
6
A new era of vitiligo research and treatment. (24023425)
2013
7
Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo. (23711243)
2013
8
Role of histamine as a toxic mediator in the pathogenesis of vitiligo. (24249891)
2013
9
Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. (22963656)
2013
10
Psoralen-narrowband UVB phototherapy in treatment of vitiligo in comparison to narrowband UVB phototherapy. (24118425)
2013
11
Type 2A Koebner's phenomenon in vitiligo is distinct from other subtypes - observations from an Indian cohort. (24111847)
2013
12
Evaluation of total oxidant and antioxidant status in localized and generalized vitiligo. (23601201)
2013
13
The association of Foxo3a gene polymorphisms with serum Foxo3a levels and oxidative stress markers in vitiligo patients. (24365591)
2013
14
Development and validation of the K-VSCOR for scoring Koebner's phenomenon in vitiligo/non-segmental vitiligo. (23302147)
2013
15
Commentary from the Editorial Board to Vitiligo: interplay between oxidative stress and immune system (Laddha et al.). (23651466)
2013
16
The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis. (23264102)
2013
17
Autoimmune signals in non-segmental vitiligo patients are associated with distinct clinical parameters and toxic exposures. (22703111)
2013
18
In vitro evaluation of a novel topical cream for vitiligo and psoriasis that selectively delivers NB-UVB therapy when exposed to sunlight. (23952638)
2013
19
Treatment of localized non-segmental vitiligo with intradermal 5-flurouracil injection combined with narrow-band ultraviolet B: a preliminary study. (21781011)
2012
20
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-I^ for autoreactive CD8a8_ T-cell accumulation in the skin. (22297636)
2012
21
The coexistence of psoriasis and vitiligo: a review. (22971303)
2012
22
Low yield of routine screening for thyroid dysfunction in asymptomatic patients with vitiligo. (22050082)
2012
23
Study of CCN3 (NOV) and DDR1 in normal melanocytes and vitiligo skin. (22507556)
2012
24
Immunohistochemical detection of P53 and Mdm2 in vitiligo. (23189248)
2012
25
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
26
Quality of life in vitiligo patients. (23237035)
2012
27
Over-expression of tumor necrosis factor-I+ in vitiligo lesions after narrow-band UVB therapy: an immunohistochemical study. (22832941)
2012
28
Glutathione S-transferase M1/T1 gene polymorphisms and vitiligo in a Mediterranean population. (21615880)
2011
29
Treatment of vitiligo: advantages and disadvantages, indications for use and outcomes. (21956273)
2011
30
Liver X receptor expression in human melanocytes, does it have a role in the pathogenesis of vitiligo? (19645823)
2010
31
Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus. (20804490)
2010
32
Expression of InnVit/FBXO11 in vitiligo and its role in tyrosinase export from endoplasmic reticulum]. (20646433)
2010
33
Autoantigens in vitiligo identified by the serological selection of a phage-displayed melanocyte cDNA expression library. (19587696)
2010
34
Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs. (20574744)
2010
35
Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (19416273)
2009
36
Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in children]. (19861278)
2009
37
Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin? (18174263)
2008
38
Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation. (18393827)
2008
39
Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivo. (17199578)
2007
40
Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo. (16405610)
2006
41
Neurofibromatosis 1/Noonan syndrome associated with Hashimoto's thyroiditis and vitiligo. (16586003)
2006
42
Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity. (16272362)
2005
43
Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice. (16117796)
2005
44
A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients. (16101862)
2005
45
Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. (15541077)
2004
46
Levels of neuropeptide-Y in the plasma and skin tissue fluids of patients with vitiligo. (11641057)
2001
47
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. (10077623)
1999
48
Serum selenium levels and blood glutathione peroxidase activities in vitiligo. (10468804)
1999
49
Successful culture of adult human melanocytes obtained from normal and vitiligo donors. (1698887)
1990
50
Vitiligo as a Sequela of Influenza and Erysipelas. (20753304)
1891

Variations for Vitiligo

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Expression for genes affiliated with Vitiligo

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitiligo

Search GEO for disease gene expression data for Vitiligo.

Pathways for genes affiliated with Vitiligo

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN
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Pathways related to Vitiligo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
10.0TYR, TYRP1
29.9CAT, TYRP1
3
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.9CAT, TYRP1
49.8CD8A, AIRE
59.5QDPR, GCH1
6
Show member pathways
9.4PTPN22, CD8A, CTLA4
7
Show member pathways
8.4TYRP1, TYR, PCBD1, CAT, GCH1, QDPR

Compounds for genes affiliated with Vitiligo

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46Novoseek, 3BitterDB, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB
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Compounds related to Vitiligo according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1dhica4610.4TYRP1, TYR
2kojic acid4610.4TYRP1, TYR
3arbutin3 4611.3TYR, TYRP1
4dopaquinone46 2511.3TYRP1, TYR
5eumelanin4610.3TYR, TYRP1
6dopachrome4610.3TYRP1, TYR
74-s-cysteaminylphenol4610.3TYR, CAT
83-hydroxyanthranilic acid46 2511.2TYR, CAT
9hmba4610.2TYRP1, TYR
107-biopterin4610.2PCBD1, QDPR
116-biopterin4610.1TYR, QDPR
12hydroquinone46 2511.1TYR, CAT
134a-hydroxytetrahydrobiopterin46 2511.1GCH1, PCBD1
14pterin46 2511.1QDPR, PCBD1
15hemocyanin4610.1TYR, CTLA4
16selenite4610.1CAT, TYR
175-hydroxytryptophan4610.0TYR, QDPR
18copper46 2510.9CAT, TYR, TYRP1
19pteridine469.8QDPR, GCH1
20agar469.8TYRP1, TYR, CAT
21indoleamine469.8CTLA4, GCH1
226-pyruvoyltetrahydropterin469.7QDPR, GCH1, PCBD1
23dihydropteridine46 2510.7PCBD1, GCH1, QDPR
24sepiapterin46 2510.7QDPR, GCH1, PCBD1
25formate469.6CAT, GCH1
26dihydrobiopterin46 2510.4TYR, PCBD1, GCH1, QDPR
27phenylalanine469.4PCBD1, GCH1, QDPR
28gtp46 3010.3TYRP1, PCBD1, GCH1, QDPR
29ascorbic acid46 2510.3GCH1, CAT, TYR
30sb 20358046 6210.2AIRE, TYR, CAT
31Water259.2TYR, PTPN22, PCBD1, CAT, GCH1
32steroid469.2QDPR, C4B, CTLA4, TYRP1
33tetrahydrobiopterin46 25 1211.1QDPR, GCH1, CAT, PCBD1, TYR
34levodopa46 1210.1TYRP1, TYR, CAT, GCH1, QDPR
35h2o2468.8TYRP1, TYR, PCBD1, CAT, GCH1, QDPR
36serine468.7AIRE, TYRP1, TYR, GCH1, CTLA4, C4B
37calcium46 52 25 1211.3QDPR, C4B, CTLA4, GCH1, MCHR1, TYRP1
38tyrosine468.0AIRE, TYRP1, TYR, PTPN22, GCH1, CD8A

GO Terms for genes affiliated with Vitiligo

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17Gene Ontology
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Cellular components related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosome membraneGO:0331629.7TYR, TYRP1
2perinuclear region of cytoplasmGO:0484718.7FGFR1OP, CTLA4, PTPN22, TYR

Biological processes related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1L-phenylalanine catabolic processGO:0065599.8QDPR, PCBD1
2tetrahydrobiopterin biosynthetic processGO:0067299.0QDPR, GCH1, PCBD1

Molecular functions related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428037.2FGFR1OP, TYRP1, TYR, CAT, GCH1, CD8A
2protein bindingGO:0055156.1TYRP1, TYR, FBXO11, PTPN22, PCBD1, NLRP1

Products for genes affiliated with Vitiligo

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Sources for Vitiligo

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet