MCID: VTL002
MIFTS: 60

Vitiligo malady

Skin diseases category

Summaries for Vitiligo

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. as a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. the average age of onset is in the mid-20s. it is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. in the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. the exact cause of vitiligo is not known, but there are several different theories. there is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. the main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments). last updated: 11/20/2012

MalaCards: Vitiligo is related to melanoma and thyroiditis. An important gene associated with Vitiligo is MCHR1 (melanin-concentrating hormone receptor 1), and among its related pathways are Phenylalanine metabolism and Basal cell carcinoma. The drugs methoxsalen and trioxsalen and the compounds tyrosine and dopachrome have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and eye, and related mouse phenotypes are homeostasis/metabolism and integument.

Disease Ontology:8 An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.

Genetics Home Reference:21 Vitiligo is a condition that causes patchy changes in skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-20s, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.

MedlinePlus:33 Vitiligo causes white patches on your skin. it can also affect your eyes, mouth, and nose. it occurs when the cells that give your skin its color are destroyed. no one knows what destroys them. it is more common in people with autoimmune diseases, and it might run in families. it usually starts before age 40. the white patches are more common where your skin is exposed to the sun. in some cases, the patches spread. vitiligo can cause your hair to gray early. if you have dark skin, you may lose color inside your mouth. using sunscreen will help protect your skin, and cosmetics can cover up the patches. treatments for vitiligo include medicines, light therapy, and surgery. not every treatment is right for everyone. many have side effects. some take a long time. some do not always work. nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia:63 Vitiligo /ˌvɪtɨˈlaɪɡoʊ/ is a condition that causes depigmentation of parts of the skin. It occurs... more...

Description from OMIM:46 193200

Aliases & Classifications for Vitiligo

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

vitiligo 8 42 21 10 44 33 30 60


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Disease Ontology8 DOID:12306
ICD9CM27 709.01
NCIt39 C26915
SNOMED-CT56 156437000, 56727007
OMIM46 193200
MeSH34 D014820
ICD1025 L80

Related Diseases for Vitiligo

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17GeneCards, 18GeneDecks
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Diseases related to Vitiligo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.8MCHR1, CAT, CTLA4, MLANA, DCT, TYR
2thyroiditis30.7CTLA4, PTPN22
3psoriasis30.7CTLA4, PTPN22
4alopecia areata30.6AIRE
5autoimmune thyroiditis30.5CTLA4, AIRE, TYRP1, PTPN22
6hypothyroidism30.3CTLA4, DCT, AIRE, TYR, TYRP1
7hepatitis30.3CAT, CTLA4, AIRE
8vitiligo-associated multiple autoimmune disease susceptibility 130.3SLEV1, NLRP1
9vogt-koyanagi-harada disease30.3TYR
10microphthalmia30.2PMEL, MLANA, DCT, TYRP1, TYR
11graves' disease30.1CTLA4, TYR, AIRE, PTPN22, DCT, TYRP1
12amelanotic melanoma29.9TYRP1, TYR, DCT
13albinism29.9TYR, DCT, TYRP1
14systemic lupus erythematosus29.9TYR, C4B, CTLA4, PTPN22
15diabetes mellitus29.9CAT, CTLA4, AIRE, PTPN22
16influenza29.7TYR, MLANA, PMEL
17vaccinia29.7TYR
18thymoma29.7AIRE, CTLA4
19oculocutaneous albinism29.7TYR, TYRP1
20celiac disease29.7PTPN22, CTLA4
21alopecia10.5
22dermatitis10.3
23lupus erythematosus10.3
24pernicious anemia10.3
25alopecia universalis10.2
26piebaldism10.2
27lichen planus10.2
28hepatitis a10.2
29skin disease10.2
30alopecia universalis onychodystrophy vitiligo10.2
31hepatitis c10.1
32atopic dermatitis10.1
33mycosis fungoides10.1
34dermatitis herpetiformis10.1
35scleroderma10.1
36deafness vitiligo achalasia10.1
37basal cell carcinoma10.1
38bullous pemphigoid10.0
39pityriasis rubra pilaris10.0
40arthritis10.0
41rheumatoid arthritis10.0
42sarcoma10.0
43squamous cell carcinoma10.0
44testicular cancer10.0TYR, PMEL, MLANA, TYRP1
45juvenile xanthogranuloma10.0TYR, MLANA, PMEL
46addison's disease10.0AIRE, CTLA4, PTPN22
47hermansky-pudlak syndrome10.0TYR, TYRP1
48hypersensitivity reaction type ii disease10.0CTLA4, PTPN22, AIRE
49intraocular melanoma10.0MLANA, TYR, PMEL
50lymphopenia10.0CAT, PTPN22

Graphical network of the top 20 diseases related to Vitiligo:



Diseases related to vitiligo

Clinical Features for Vitiligo

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Sources:
46OMIM
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Clinical features from OMIM:

193200

Drugs & Therapeutics for Vitiligo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vitiligo

Drug clinical trials:

Search ClinicalTrials for Vitiligo

Search NIH Clinical Center for Vitiligo

Search CenterWatch for Vitiligo

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Vitiligo cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Vitiligo:
JACE
Embryonic/Adult Cultured Cells Related to Vitiligo:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Vitiligo

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Anatomical Context for Vitiligo

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32MalaCards
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MalaCards organs/tissues related to Vitiligo:

32
Skin, Thyroid, Eye, Retina, T cells, Testes, Liver, Heart, Bone, B cells, Thymus

Animal Models for Vitiligo or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vitiligo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3TYRP1, PMEL, NLRP1, CTLA4, C4B, FBXO11
2MP:001077111.2DCT, FBXO11, TYR, MLANA, PCBD1, CD8A
3MP:001076811.1CD8A, TYRP1, TYR, AIRE, FBXO11, C4B
4MP:000118611.0PMEL, PCBD1, TYRP1, TYR, DCT, MLANA
5MP:000539110.8TYR, AIRE, DCT, FBXO11, TYRP1, PMEL
6MP:000539710.7AIRE, PTPN22, CD8A, FBXO11, C4B, CTLA4

Publications for Vitiligo

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Sources:
50PubMed
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Articles related to Vitiligo:

(show top 50)    (show all 877)
idTitleAuthorsYear
1
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
2
The association of Foxo3a gene polymorphisms with serum Foxo3a levels and oxidative stress markers in vitiligo patients. (24365591)
2013
3
Modern vitiligo genetics sheds new light on an ancient disease. (23668538)
2013
4
Association of HLA alleles and haplotypes with vitiligo in Moroccan patients: a case-control study. (23700241)
2013
5
Biology and genetics of oculocutaneous albinism and vitiligo - common pigmentation disorders in southern Africa. (24300644)
2013
6
Innate immune mechanisms in vitiligo: danger from within. (24238922)
2013
7
Acral vitiligo and lesions over joints treated with non-cultured epidermal cell suspension transplantation. (23531153)
2013
8
Vitiligo: an evidence-based update. Report of the 13(th) Evidence Based Update Meeting, 23(rd) May 2013, Loughborough, UK. (24131286)
2013
9
Efficacy of levamisole for the treatment of slow spreading vitiligo. (24292309)
2013
10
A central role for inducible heat-shock protein 70 in autoimmune vitiligo. (23786523)
2013
11
Colocalization of vitiligo and alopecia areata: coincidence or consequence? (23960402)
2013
12
Mutant HSP70 reverses autoimmune depigmentation in vitiligo. (23447019)
2013
13
Potential advantages of simvastatin as a novel anti-vitiligo arsenal. (23877867)
2013
14
Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial. (23551324)
2013
15
The coexistence of psoriasis and vitiligo: a review. (22971303)
2012
16
Serum 25-hydroxyvitamin D deficiency in Chinese patients with vitiligo: a case-control study. (23300773)
2012
17
Hair depigmentation and vitiligo-like lesions in a leukaemic paediatric patient during chemotherapy with dasatinib. (22307953)
2012
18
Circumcised foreskin may be useful as a donor tissue during an autologous, non-cultured, epidermal cell transplantation for the treatment of widespread vitiligo. (22720324)
2012
19
Development of melanocye-keratinocyte co-culture model for controls and vitiligo to assess regulators of pigmentation and melanocytes. (22960816)
2012
20
A review of monochromatic excimer light in vitiligo. (22524428)
2012
21
A proposal for the treatment guideline in segmental vitiligo. (22233150)
2012
22
Role of keratinocytes in the development of vitiligo. (22577260)
2012
23
Survey of dermatologists' phototherapy practices for vitiligo. (22199064)
2012
24
The Newest Hypothesis about Vitiligo: Most of the Suggested Pathogeneses of Vitiligo Can Be Attributed to Lack of One Factor, Zinc-I+2-Glycoprotein. (22778983)
2012
25
Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo. (22846211)
2012
26
Intelligent bioengineering in vitiligo treatment: transdermal protein transduction of melanocyte-lineage-specific genes. (22999738)
2012
27
Late onset vitiligo and audiological abnormalities: is there any association? (21860155)
2011
28
Analysis of inducible nitric oxide synthase gene polymorphisms in vitiligo in Han Chinese people. (22205923)
2011
29
Vitiligo during Treatment of Crohn's Disease with Adalimumab: Adverse Effect or Co-Occurrence? (21931575)
2011
30
Effect of 0.1% tacrolimus ointment in localized vitiligo: an open uncontrolled trial. (21965863)
2011
31
Photo(chemo)therapy for vitiligo. (21950634)
2011
32
Vitiligo-epidemiological study of 4134 patients at the National Center for Vitiligo and Psoriasis in Central Saudi Arabia. (22159386)
2011
33
Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population. (22058000)
2011
34
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. (20410501)
2010
35
Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population. (19843086)
2010
36
Membrane lipid defects are responsible for the generation of reactive oxygen species in peripheral blood mononuclear cells from vitiligo patients. (20049874)
2010
37
Vitiligo-like depigmentation induced by imiquimod treatment of superficial basal cell carcinoma. (19659986)
2009
38
Extragenital lichen sclerosus and atrophicus treated with topical steroids and retinoids in a child with vitiligo. (18831946)
2008
39
Keratoacanthoma in vitiligo lesion after UVB narrowband phototherapy. (16869872)
2006
40
Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo. (16528352)
2006
41
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. (14766237)
2004
42
Efficacy of antioxidants as an adjunct to photochemotherapy in vitiligo: a case study of 30 patients. (17656936)
2002
43
Keratinocytes suppress TRP-1 expression and reduce cell number of co-cultured melanocytes - implications for grafting of patients with vitiligo. (11310791)
2001
44
Oral dexamethasone pulse treatment for vitiligo. (11312430)
2001
45
Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: an evaluation. (10385915)
1999
46
Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice. (9825864)
1998
47
Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo. (9118024)
1997
48
Vitiligo and pernicious anemia presenting as congestive heart failure. (2225934)
1990
49
Pityriasis rubra pilaris and vitiligo in Down's syndrome. (2978467)
1988
50
ALOPECIA UNIVERSALIS, ONYCHODYSTROPHY, AND TOTAL VITILIGO. (14043609)
1963

Genetic Variations for Vitiligo

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Expression for genes affiliated with Vitiligo

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitiligo

Search GEO for disease gene expression data for Vitiligo.

Pathways for genes affiliated with Vitiligo

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29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Vitiligo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TYRP1, TYR, DCT
2
Hide members
10.7TYRP1, TYR, DCT
3
Hide members
10.7PTPN22, CD8A, CTLA4
4
Hide members
10.6CAT, TYRP1
510.6TYRP1, CAT

Compounds for genes affiliated with Vitiligo

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44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Vitiligo according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.3PTPN22, CTLA4, LPO, DCT, AIRE, TYR
2dopachrome4411.1TYR, TYRP1, PMEL, DCT
3levodopa44 1112.1TYRP1, CAT, TYR, DCT
4dhica4411.1DCT, TYR, TYRP1
5copper44 2412.1TYR, DCT, CAT, TYRP1
6arbutin2 4412.1TYRP1, DCT, TYR
7dopaquinone44 2412.0TYRP1, DCT, TYR
8eumelanin4411.0TYR, DCT, TYRP1
9hemocyanin4411.0CTLA4, TYR, PMEL
10hmba4411.0DCT, TYRP1, TYR
11tetrahydrobiopterin44 11 2413.0TYR, CAT, PCBD1
12cysteine4411.0TYRP1, TYR, LPO, CTLA4, CAT, DCT
13l-dopachrome44 2411.9DCT, TYR
144-s-cysteaminylphenol4410.9CAT, TYR
15kojic acid4410.9TYR, TYRP1
165,6-dihydroxyindole44 2411.9TYR, DCT
17salicylhydroxamic acid4410.9LPO, CAT
18resorcinol4410.9LPO, TYR
19h2o24410.9TYR, LPO, TYRP1, PCBD1, CAT
203-hydroxyanthranilic acid44 2411.9TYR, CAT
21dmpo4410.8LPO, CAT
22lecithin4410.8DCT, TYRP1
23silver4410.8PMEL, TYRP1, DCT
24guaiacol44 2411.8LPO, CAT
25dihydrobiopterin44 2411.8PCBD1, TYR
26ibmx44 28 5912.7TYR, DCT, TYRP1
27azide4410.6CAT, LPO
28cyanide44 2411.5LPO, DCT
29trolox4410.3LPO, CAT

GO Terms for genes affiliated with Vitiligo

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16Gene Ontology
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Cellular components related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosome membraneGO:03316210.7TYRP1, TYR, DCT
2melanosomeGO:04247010.5TYRP1, TYR, DCT, MLANA, PMEL

Biological processes related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanin biosynthetic process from tyrosineGO:00658310.6TYR, DCT
2hydrogen peroxide catabolic processGO:04274410.6LPO, CAT
3melanin biosynthetic processGO:04243810.5TYRP1, PMEL
4melanosome organizationGO:03243810.3TYRP1, PMEL

Molecular functions related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3TYR, PTPN22, FGFR1OP, PCBD1, CD8A, PMEL
2copper ion bindingGO:00550710.6TYRP1, TYR, DCT
3protein homodimerization activityGO:04280310.5TYR, TYRP1, CD8A, FGFR1OP, CAT

Products for genes affiliated with Vitiligo

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Sources for Vitiligo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet