MCID: VTL002
MIFTS: 61

Vitiligo malady

Rare diseases, Skin diseases, Immune diseases categories
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Summaries for Vitiligo

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NIH Rare Diseases:42 Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. as a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. the average age of onset is in the mid-20s. it is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. in the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. the exact cause of vitiligo is not known, but there are several different theories. there is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. the main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments). last updated: 11/20/2012

MalaCards based summary: Vitiligo is related to thyroiditis and vogt-koyanagi-harada disease. An important gene associated with Vitiligo is NLRP1 (NLR family, pyrin domain containing 1), and among its related pathways are Phenylalanine metabolism and superoxide radicals degradation. The drugs methoxsalen and trioxsalen and the compounds kojic acid and dhica have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and thyroid, and related mouse phenotypes are pigmentation and liver/biliary system.

Disease Ontology:8 A hypersensitivity reaction type ii disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.

Genetics Home Reference:21 Vitiligo is a condition that causes patchy changes in skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-20s, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.

MedlinePlus:33 Vitiligo causes white patches on your skin. it can also affect your eyes, mouth, and nose. it occurs when the cells that give your skin its color are destroyed. no one knows what destroys them. it is more common in people with autoimmune diseases, and it might run in families. it usually starts before age 40. the white patches are more common where your skin is exposed to the sun. in some cases, the patches spread. vitiligo can cause your hair to gray early. if you have dark skin, you may lose color inside your mouth. using sunscreen will help protect your skin, and cosmetics can cover up the patches. treatments for vitiligo include medicines, light therapy, and surgery. not every treatment is right for everyone. many have side effects. some take a long time. some do not always work. nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia:65 Vitiligo /?v?t??la??o?/ is a condition that causes depigmentation of parts of the skin. It occurs when... more...

Description from OMIM:46 193200

Aliases & Classifications for Vitiligo

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Vitiligo, Aliases & Descriptions:

Name: Vitiligo 30 8 42 21 10 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases


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Disease Ontology8 DOID:12306
ICD9CM27 709.01
OMIM46 193200
SNOMED-CT57 56727007, 156437000
MeSH34 D014820
NCIt39 C26915
ICD1025 L80

Related Diseases for Vitiligo

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Diseases related to Vitiligo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.1PTPN22, CTLA4
2vogt-koyanagi-harada disease31.1TYR
3amelanotic melanoma30.5TYRP1, TYR
4albinism30.5TYRP1, TYR
5autoimmune thyroiditis30.4CTLA4, TYRP1, AIRE, PTPN22
6hypothyroidism30.3TYRP1, TYR, AIRE, CTLA4
7oculocutaneous albinism30.2TYRP1, TYR
8hepatitis30.2CTLA4, CAT, AIRE
9melanoma30.2MCHR1, CAT, CTLA4, CD8A, TYR, TYRP1
10myasthenia gravis30.0AIRE, CTLA4
11graves' disease29.8CTLA4, PTPN22, TYR, AIRE, TYRP1
12systemic lupus erythematosus29.8C4B, CTLA4, TYR, PTPN22
13autoimmune hepatitis29.8AIRE, CTLA4
14type 1 diabetes mellitus29.7CTLA4, PTPN22, AIRE
15diabetes mellitus29.7CTLA4, CAT, PTPN22, AIRE
16alopecia10.6
17psoriasis10.5
18alopecia areata10.5
19dermatitis10.4
20lupus erythematosus10.4
21halo nevi10.3
22waardenburg's syndrome10.3TYRP1, TYR
23congenital deafness with vitiligo and achalasia10.3
24ocular albinism10.3TYRP1, TYR
25vitiligo-associated multiple autoimmune disease susceptibility 110.3
26hermansky-pudlak syndrome10.3TYRP1, TYR
27pernicious anemia10.3
28alopecia universalis10.3
29discoid lupus erythematosus10.3
30lichen planus10.2
31piebaldism10.2
32alopecia universalis onychodystrophy vitiligo10.2
33wegener's granulomatosis10.2CTLA4
34mycosis fungoides10.2
35hepatitis c10.2
36microphthalmia10.2
37atopic dermatitis10.2
38dermatitis herpetiformis10.2
39scleroderma10.2
40skin disease10.1
41basal cell carcinoma10.1
42twenty-nail dystrophy10.1
43factor vii deficiency10.1TYR, CTLA4
44phenylketonuria10.1PCBD1, QDPR
45arthritis10.1
46rheumatoid arthritis10.1
47pityriasis rubra pilaris10.1
48bullous pemphigoid10.1
49acanthosis nigricans10.1
50sarcoma10.1

Graphical network of the top 20 diseases related to Vitiligo:



Diseases related to vitiligo

Symptoms for Vitiligo

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Clinical features from OMIM:

193200

Drugs & Therapeutics for Vitiligo

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Drug clinical trials:

Search ClinicalTrials for Vitiligo

Search NIH Clinical Center for Vitiligo

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Vitiligo cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Vitiligo:
JACE
Embryonic/Adult Cultured Cells Related to Vitiligo:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Vitiligo

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Anatomical Context for Vitiligo

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MalaCards organs/tissues related to Vitiligo:

32
Skin, Eye, Thyroid, T cells, Retina, Testes, Liver, Bone, Thymus, Heart, B cells

Animal Models for Vitiligo or affiliated genes

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Publications for Vitiligo

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Articles related to Vitiligo:

(show top 50)    (show all 892)
idTitleAuthorsYear
1
Alteration in regulatory T cells and programmed death (PD)1 expressing regulatory T cells in active generalized vitiligo and their clinical correlation. (25376752)
2014
2
Vitiligo Extent Tensity Index (VETI) score: a new definition, assessment and treatment evaluation criteria in vitiligo. (25396094)
2014
3
Anti-SRP Antibody-positive Myopathy with Universal Alopecia and Multiple Vitiligo. (25325714)
2014
4
BB-UVA vs. NB-UVB in the treatment of vitiligo: a randomized controlled clinical study (single blinded). (24001379)
2013
5
The association between a single nucleotide polymorphism rs11966200 in MHC region and clinical features of generalized vitiligo in Chinese Han population. (23516070)
2013
6
Autoimmune thyroid disease in vitiligo: multivariate analysis indicates intricate pathomechanisms. (23253044)
2013
7
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
8
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
9
A new era of vitiligo research and treatment. (24023425)
2013
10
Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo. (23711243)
2013
11
Role of histamine as a toxic mediator in the pathogenesis of vitiligo. (24249891)
2013
12
Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. (22963656)
2013
13
Psoralen-narrowband UVB phototherapy in treatment of vitiligo in comparison to narrowband UVB phototherapy. (24118425)
2013
14
Comparison of the psychological impacts of asymptomatic and symptomatic cutaneous diseases: vitiligo and atopic dermatitis. (24371393)
2013
15
Type 2A Koebner's phenomenon in vitiligo is distinct from other subtypes - observations from an Indian cohort. (24111847)
2013
16
Evaluation of total oxidant and antioxidant status in localized and generalized vitiligo. (23601201)
2013
17
The association of Foxo3a gene polymorphisms with serum Foxo3a levels and oxidative stress markers in vitiligo patients. (24365591)
2013
18
Development and validation of the K-VSCOR for scoring Koebner's phenomenon in vitiligo/non-segmental vitiligo. (23302147)
2013
19
Commentary from the Editorial Board to Vitiligo: interplay between oxidative stress and immune system (Laddha et al.). (23651466)
2013
20
The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis. (23264102)
2013
21
Treatment of localized non-segmental vitiligo with intradermal 5-flurouracil injection combined with narrow-band ultraviolet B: a preliminary study. (21781011)
2012
22
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-I^ for autoreactive CD8a8_ T-cell accumulation in the skin. (22297636)
2012
23
The coexistence of psoriasis and vitiligo: a review. (22971303)
2012
24
Low yield of routine screening for thyroid dysfunction in asymptomatic patients with vitiligo. (22050082)
2012
25
Study of CCN3 (NOV) and DDR1 in normal melanocytes and vitiligo skin. (22507556)
2012
26
Immunohistochemical detection of P53 and Mdm2 in vitiligo. (23189248)
2012
27
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
28
Quality of life in vitiligo patients. (23237035)
2012
29
Glutathione S-transferase M1/T1 gene polymorphisms and vitiligo in a Mediterranean population. (21615880)
2011
30
Treatment of vitiligo: advantages and disadvantages, indications for use and outcomes. (21956273)
2011
31
Liver X receptor expression in human melanocytes, does it have a role in the pathogenesis of vitiligo? (19645823)
2010
32
Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus. (20804490)
2010
33
Expression of InnVit/FBXO11 in vitiligo and its role in tyrosinase export from endoplasmic reticulum]. (20646433)
2010
34
Autoantigens in vitiligo identified by the serological selection of a phage-displayed melanocyte cDNA expression library. (19587696)
2010
35
Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (19416273)
2009
36
Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in children]. (19861278)
2009
37
Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin? (18174263)
2008
38
Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation. (18393827)
2008
39
Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivo. (17199578)
2007
40
Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo. (16405610)
2006
41
Neurofibromatosis 1/Noonan syndrome associated with Hashimoto's thyroiditis and vitiligo. (16586003)
2006
42
Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity. (16272362)
2005
43
Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice. (16117796)
2005
44
A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients. (16101862)
2005
45
Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. (15541077)
2004
46
Levels of neuropeptide-Y in the plasma and skin tissue fluids of patients with vitiligo. (11641057)
2001
47
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. (10077623)
1999
48
Serum selenium levels and blood glutathione peroxidase activities in vitiligo. (10468804)
1999
49
Successful culture of adult human melanocytes obtained from normal and vitiligo donors. (1698887)
1990
50
Vitiligo as a Sequela of Influenza and Erysipelas. (20753304)
1891

Variations for Vitiligo

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Expression for genes affiliated with Vitiligo

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Expression patterns in normal tissues for genes affiliated with Vitiligo

Search GEO for disease gene expression data for Vitiligo.

Pathways for genes affiliated with Vitiligo

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Pathways related to Vitiligo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
10.0TYR, TYRP1
29.9CAT, TYRP1
3
Show member pathways
acetate conversion to acetyl-CoA37
oxidative ethanol degradation III37
ethanol degradation IV37
9.9CAT, TYRP1
49.8CD8A, AIRE
59.5QDPR, GCH1
6
Show member pathways
9.4CTLA4, CD8A, PTPN22
7
Show member pathways
8.4PCBD1, TYRP1, QDPR, GCH1, CAT, TYR

Compounds for genes affiliated with Vitiligo

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Compounds related to Vitiligo according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1kojic acid4410.3TYRP1, TYR
2dhica4410.3TYRP1, TYR
3arbutin2 4411.3TYRP1, TYR
4dopaquinone44 2411.3TYRP1, TYR
5eumelanin4410.3TYRP1, TYR
6dopachrome4410.3TYR, TYRP1
74-s-cysteaminylphenol4410.3CAT, TYR
83-hydroxyanthranilic acid44 2411.2CAT, TYR
9hmba4410.2TYRP1, TYR
107-biopterin4410.2PCBD1, QDPR
116-biopterin4410.1TYR, QDPR
12hydroquinone44 2411.1TYR, CAT
134a-hydroxytetrahydrobiopterin44 2411.1PCBD1, GCH1
14pterin44 2411.1PCBD1, QDPR
15hemocyanin4410.1CTLA4, TYR
16selenite4410.1TYR, CAT
175-hydroxytryptophan4410.1TYR, QDPR
18copper44 2410.9TYRP1, TYR, CAT
19pteridine449.8GCH1, QDPR
20indoleamine449.8GCH1, CTLA4
21agar449.8CAT, TYR, TYRP1
226-pyruvoyltetrahydropterin449.7GCH1, PCBD1, QDPR
23dihydropteridine44 2410.7PCBD1, GCH1, QDPR
24sepiapterin44 2410.7PCBD1, GCH1, QDPR
25formate449.6GCH1, CAT
26dihydrobiopterin44 2410.4TYR, PCBD1, QDPR, GCH1
27phenylalanine449.4GCH1, PCBD1, QDPR
28gtp44 2810.3GCH1, TYRP1, PCBD1, QDPR
29ascorbic acid44 2410.3GCH1, TYR, CAT
30sb 20358044 6110.2TYR, CAT, AIRE
31Water249.2PTPN22, GCH1, CAT, PCBD1, TYR
32steroid449.2C4B, TYRP1, QDPR, CTLA4
33tetrahydrobiopterin44 24 1111.1GCH1, CAT, PCBD1, TYR, QDPR
34levodopa44 1110.1TYRP1, CAT, GCH1, QDPR, TYR
35h2o2448.8TYRP1, TYR, PCBD1, CAT, GCH1, QDPR
36serine448.7CTLA4, TYR, GCH1, C4B, AIRE, TYRP1
37calcium44 50 24 1111.3TYRP1, GCH1, CTLA4, C4B, QDPR, MCHR1
38tyrosine448.0CTLA4, GCH1, CD8A, QDPR, TYRP1, AIRE

GO Terms for genes affiliated with Vitiligo

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Cellular components related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosome membraneGO:0331629.7TYR, TYRP1
2perinuclear region of cytoplasmGO:0484718.7FGFR1OP, CTLA4, PTPN22, TYR

Biological processes related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1L-phenylalanine catabolic processGO:0065599.8QDPR, PCBD1
2tetrahydrobiopterin biosynthetic processGO:0067299.0QDPR, GCH1, PCBD1

Molecular functions related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428037.2TYRP1, TYR, CAT, GCH1, CD8A, QDPR
2protein bindingGO:0055156.1AIRE, TYRP1, TYR, FBXO11, PTPN22, PCBD1

Products for genes affiliated with Vitiligo

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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
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