MCID: VTL002
MIFTS: 60

Vitiligo malady

Skin diseases category

Summaries for Vitiligo

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. as a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. the average age of onset is in the mid-20s. it is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. in the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. the exact cause of vitiligo is not known, but there are several different theories. there is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. the main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments). last updated: 11/20/2012

MalaCards: Vitiligo is related to melanoma and thyroiditis. An important gene associated with Vitiligo is MCHR1 (melanin-concentrating hormone receptor 1), and among its related pathways are Phenylalanine metabolism and Basal cell carcinoma. The drugs methoxsalen and trioxsalen and the compounds tyrosine and dopachrome have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and eye, and related mouse phenotypes are homeostasis/metabolism and integument.

Disease Ontology:8 An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.

MedlinePlus:33 Vitiligo causes white patches on your skin. it can also affect your eyes, mouth, and nose. it occurs when the cells that give your skin its color are destroyed. no one knows what destroys them. it is more common in people with autoimmune diseases, and it might run in families. it usually starts before age 40. the white patches are more common where your skin is exposed to the sun. in some cases, the patches spread. vitiligo can cause your hair to gray early. if you have dark skin, you may lose color inside your mouth. using sunscreen will help protect your skin, and cosmetics can cover up the patches. treatments for vitiligo include medicines, light therapy, and surgery. not every treatment is right for everyone. many have side effects. some take a long time. some do not always work. nih: national institute of arthritis and musculoskeletal and skin diseases

Genetics Home Reference:21 Vitiligo is a condition that causes patchy changes in skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-20s, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.

Wikipedia:63 Vitiligo /ˌvɪtɨˈlaɪɡoʊ/ is a condition that causes depigmentation of parts of the skin. It occurs... more...

Description from OMIM:46 193200

Aliases & Classifications for Vitiligo

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

vitiligo 8 42 21 10 44 33 30 60


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Disease Ontology8 DOID:12306
ICD9CM27 709.01
NCIt39 C26915
SNOMED-CT56 156437000, 56727007
OMIM46 193200
MeSH34 D014820
ICD1025 L80

Related Diseases for Vitiligo

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17GeneCards, 18GeneDecks
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Diseases related to Vitiligo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.8MCHR1, CAT, CTLA4, MLANA, DCT, TYR
2thyroiditis30.7CTLA4, PTPN22
3psoriasis30.7CTLA4, PTPN22
4alopecia areata30.6AIRE
5autoimmune thyroiditis30.5CTLA4, AIRE, TYRP1, PTPN22
6hypothyroidism30.3CTLA4, DCT, AIRE, TYR, TYRP1
7hepatitis30.3CAT, CTLA4, AIRE
8vitiligo-associated multiple autoimmune disease susceptibility 130.3SLEV1, NLRP1
9vogt-koyanagi-harada disease30.3TYR
10microphthalmia30.2PMEL, MLANA, DCT, TYRP1, TYR
11graves' disease30.1CTLA4, TYR, AIRE, PTPN22, DCT, TYRP1
12amelanotic melanoma29.9TYRP1, TYR, DCT
13albinism29.9TYR, DCT, TYRP1
14systemic lupus erythematosus29.9TYR, C4B, CTLA4, PTPN22
15diabetes mellitus29.9CAT, CTLA4, AIRE, PTPN22
16influenza29.7TYR, MLANA, PMEL
17vaccinia29.7TYR
18thymoma29.7AIRE, CTLA4
19oculocutaneous albinism29.7TYR, TYRP1
20celiac disease29.7PTPN22, CTLA4
21alopecia10.5
22dermatitis10.3
23lupus erythematosus10.3
24pernicious anemia10.3
25alopecia universalis10.2
26piebaldism10.2
27lichen planus10.2
28hepatitis a10.2
29skin disease10.2
30alopecia universalis onychodystrophy vitiligo10.2
31hepatitis c10.1
32atopic dermatitis10.1
33mycosis fungoides10.1
34dermatitis herpetiformis10.1
35scleroderma10.1
36deafness vitiligo achalasia10.1
37basal cell carcinoma10.1
38bullous pemphigoid10.0
39pityriasis rubra pilaris10.0
40arthritis10.0
41rheumatoid arthritis10.0
42sarcoma10.0
43squamous cell carcinoma10.0
44testicular cancer10.0TYR, PMEL, MLANA, TYRP1
45juvenile xanthogranuloma10.0TYR, MLANA, PMEL
46addison's disease10.0AIRE, CTLA4, PTPN22
47hermansky-pudlak syndrome10.0TYR, TYRP1
48hypersensitivity reaction type ii disease10.0CTLA4, PTPN22, AIRE
49intraocular melanoma10.0MLANA, TYR, PMEL
50lymphopenia10.0CAT, PTPN22

Graphical network of the top 20 diseases related to Vitiligo:



Diseases related to vitiligo

Clinical Features for Vitiligo

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Sources:
46OMIM
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Clinical features from OMIM:

193200

Drugs & Therapeutics for Vitiligo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vitiligo

Drug clinical trials:

Search ClinicalTrials for Vitiligo

Search NIH Clinical Center for Vitiligo

Search CenterWatch for Vitiligo

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Vitiligo cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Vitiligo:
JACE
Embryonic/Adult Cultured Cells Related to Vitiligo:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Vitiligo

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Anatomical Context for Vitiligo

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32MalaCards
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MalaCards organs/tissues related to Vitiligo:

32
Skin, Thyroid, Eye, Retina, T cells, Testes, Liver, Heart, Bone, B cells, Thymus

Animal Models for Vitiligo or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vitiligo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3C4B, CTLA4, CAT, NLRP1, PMEL, FBXO11
2MP:001077111.2PMEL, NLRP1, CTLA4, FBXO11, MLANA, DCT
3MP:001076811.1CAT, CTLA4, C4B, FBXO11, AIRE, TYR
4MP:000118611.0PCBD1, PMEL, CTLA4, MLANA, DCT, TYR
5MP:000539110.8PMEL, FBXO11, DCT, AIRE, TYR, TYRP1
6MP:000539710.7PMEL, NLRP1, CTLA4, C4B, FBXO11, AIRE

Publications for Vitiligo

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Sources:
50PubMed
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Articles related to Vitiligo:

(show top 50)    (show all 877)
idTitleAuthorsYear
1
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
2
Commentary from the Editorial Board to Vitiligo: interplay between oxidative stress and immune system (Laddha et al.). (23651466)
2013
3
Depigmentation patterns of nonsegmental vitiligo: a prospective study of macromorphologic changes in lesions. (23329080)
2013
4
New suggestive clue to the mechanism of vitiligo: inflammatory vitiligo showing prominent leukocytoclasis at the erythematous rim. (23621749)
2013
5
Association between vitiligo extent and distribution and quality-of-life impairment. (23560296)
2013
6
Photoletter to the editor: Dermatitis herpetiformis co-localised with vitiligo in a patient with autoimmune polyglandular syndrome. (24133566)
2013
7
International Vitiligo Symposium, Shenyang, China, November 16-18, 2012. (23347317)
2013
8
Vitiligo vulgaris in a patient of progeria. (23716861)
2013
9
Evaluation of serum 25-hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases. (23281695)
2013
10
Guidelines for the management of vitiligo: the European Dermatology Forum consensus. (22860621)
2013
11
Impact of genital involvement on the sexual lives of vitiligo patients. (24330180)
2013
12
Non-cultured melanocyte/keratinocyte transplantation for the treatment of stable vitiligo on the face: report of two cases. (24173191)
2013
13
Prevalence of vitiligo among type 2 diabetic patients in an Iranian population. (24134629)
2013
14
Vitiligo: Emerging paradigms. (22199055)
2012
15
Expression profile of genes associated with the dopamine pathway in vitiligo skin biopsies and blood sera. (22572099)
2012
16
Quality of life among Malaysian patients with vitiligo. (22250623)
2012
17
Segmental vitiligo: a randomized controlled trial to evaluate efficacy and safety of 0.1% tacrolimus ointment vs 0.05% fluticasone propionate cream. (22199063)
2012
18
Successful treatment of extensive vitiligo with monobenzone. (23277803)
2012
19
Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris. (22983179)
2012
20
Vitiligo exacerbated after herpes zoster. (22390749)
2012
21
Vitiligo in children: a clinical-epidemiologic study in Jordan. (21854414)
2012
22
Narrowband ultraviolet B phototherapy in childhood vitiligo: evaluation of results in 28 patients. (22329609)
2012
23
Letter to the editor: Involvement of the epidermal grafting area in the recurrence of segmental vitiligo. (23738935)
2012
24
A descriptive study to characterize segmental vitiligo. (23075640)
2012
25
Circulatory levels of T-cell cytokines (interleukin [IL]-2, IL-4, IL-17, and transforming growth factor-I^) in patients with vitiligo. (22342018)
2012
26
DKK1 is highly expressed in the dermis of vitiligo lesion: is there association between DKK1 and vitiligo? (22386696)
2012
27
Squamous cell carcinoma complicating vitiligo in an Indian man. (22557854)
2012
28
Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. (21085187)
2011
29
Mercury levels in vitiligo patients. (22202514)
2011
30
An approach to the correlation between vitiligo and autoimmune thyroiditis in Chinese children. (19874359)
2010
31
Inflammatory Vitiligo or Hypopigmented Mycosis Fungoides? (20418787)
2010
32
Coexistence of granular cell tumor and schwannoma in a patient with vitiligo. (20375935)
2010
33
Dysfunction of glutathione S-transferase leads to excess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients. (20070240)
2010
34
Vitiligo occurring at site of interferon-alpha 2b injection in a patient with chronic viral hepatitis C: a case report. (18498412)
2008
35
Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivo. (17199578)
2007
36
Twenty nail dystrophy in vitiligo. (17291300)
2007
37
Acquired haemophilia heralded by bleeding into the oral mucosa in a patient with bullous pemphigoid, rheumatoid arthritis, and vitiligo. (16397069)
2006
38
Aspirin reduces serum anti-melanocyte antibodies and soluble interleukin-2 receptors in vitiligo patients. (16047057)
2005
39
The role of oxidants and antioxidants in generalized vitiligo at tissue level. (15482295)
2004
40
On the etiology of contact/occupational vitiligo. (15140065)
2004
41
Association of HLA class I antigens and HLA class II alleles with vitiligo in a Turkish population. (15016308)
2004
42
Alterations of mitochondria in peripheral blood mononuclear cells of vitiligo patients. (12950736)
2003
43
Vitiligo antibodies are not directed to tyrosinase. (10206048)
1999
44
Alopecia totalis and vitiligo in common variable immunodeficiency. (2062780)
1991
45
Can C4AQO decreased frequency be considered a genetic marker for vitiligo and familial melanoma? (2394312)
1990
46
Psoriasis, necrobiosis lipoidica, granuloma annulare, vitiligo and skin infections in the same diabetic patient. (2229646)
1990
47
Vitiligo and alcoholic liver cirrhosis. (3494395)
1987
48
Vitiligo with an inflammatory erythema in Vogt-Koyanagi-Harada disease: demonstration of filamentous masses and amyloid deposits. (7119218)
1982
49
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
50
Thyrotoxicosis; exophthalmic ophthalmoplegia, myasthenia gravis and vitiligo. (18210580)
1949

Genetic Variations for Vitiligo

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Expression for genes affiliated with Vitiligo

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vitiligo

Search GEO for disease gene expression data for Vitiligo.

Pathways for genes affiliated with Vitiligo

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29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Vitiligo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TYRP1, TYR, DCT
2
Hide members
10.7TYRP1, TYR, DCT
3
Hide members
10.7PTPN22, CD8A, CTLA4
4
Hide members
10.6CAT, TYRP1
510.6TYRP1, CAT

Compounds for genes affiliated with Vitiligo

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44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Vitiligo according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.3CTLA4, LPO, DCT, AIRE, TYR, TYRP1
2dopachrome4411.1TYRP1, TYR, DCT, PMEL
3levodopa44 1112.1CAT, DCT, TYR, TYRP1
4dhica4411.1DCT, TYR, TYRP1
5copper44 2412.1CAT, DCT, TYR, TYRP1
6arbutin2 4412.1TYRP1, TYR, DCT
7dopaquinone44 2412.0DCT, TYR, TYRP1
8eumelanin4411.0TYRP1, TYR, DCT
9hemocyanin4411.0TYR, CTLA4, PMEL
10hmba4411.0TYRP1, TYR, DCT
11tetrahydrobiopterin44 11 2413.0CAT, TYR, PCBD1
12cysteine4411.0TYRP1, TYR, DCT, LPO, CTLA4, CAT
134-s-cysteaminylphenol4410.9CAT, TYR
14kojic acid4410.9TYR, TYRP1
15l-dopachrome44 2411.9DCT, TYR
16salicylhydroxamic acid4410.9LPO, CAT
175,6-dihydroxyindole44 2411.9TYR, DCT
18resorcinol4410.9LPO, TYR
19h2o24410.9CAT, LPO, TYR, TYRP1, PCBD1
20lecithin4410.9DCT, TYRP1
213-hydroxyanthranilic acid44 2411.9CAT, TYR
22dmpo4410.8CAT, LPO
23silver4410.8PMEL, DCT, TYRP1
24guaiacol44 2411.8LPO, CAT
25dihydrobiopterin44 2411.8PCBD1, TYR
26ibmx44 28 5912.7TYRP1, TYR, DCT
27azide4410.6LPO, CAT
28cyanide44 2411.5LPO, DCT
29trolox4410.3LPO, CAT

GO Terms for genes affiliated with Vitiligo

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16Gene Ontology
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Cellular components related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosome membraneGO:03316210.7TYRP1, TYR, DCT
2melanosomeGO:04247010.5TYRP1, TYR, DCT, MLANA, PMEL

Biological processes related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanin biosynthetic process from tyrosineGO:00658310.6TYR, DCT
2hydrogen peroxide catabolic processGO:04274410.6LPO, CAT
3melanin biosynthetic processGO:04243810.5TYRP1, PMEL
4melanosome organizationGO:03243810.3TYRP1, PMEL

Molecular functions related to Vitiligo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3NLRP1, CTLA4, FBXO11, MLANA, AIRE, TYR
2copper ion bindingGO:00550710.6TYRP1, TYR, DCT
3protein homodimerization activityGO:04280310.5CAT, TYR, TYRP1, CD8A, FGFR1OP

Products for genes affiliated with Vitiligo

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Sources for Vitiligo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet