Vitiligo malady

MedlinePlus: Vitiligo causes white patches on your skin. it can also affect your eyes, mouth and nose. it occurs when the cells that give your skin its color are destroyed. no one knows what destroys them. it is more common in people with autoimmune diseases, and it might run in families. it usually starts before age 40. the white patches are more common where your skin is exposed to the sun. in some cases, the patches spread. vitiligo can cause your hair to gray early. if you have dark skin, you may lose color inside your mouth. using sunscreen will help protect your skin, and cosmetics can cover up the patches. treatments for vitiligo include medicines, light therapy and surgery. not every treatment is right for everyone. many have side effects. some take a long time. some do not always work. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Vitiligo, also known as vitiligo (disorder), is related to systemic lupus erythematosus and hepatitis. An important gene associated with Vitiligo is FBXO11 (F-box protein 11), and among its related pathways are Tyrosine metabolism and Tyrosine metabolism p.1 (dopamine). The drugs trioxsalen and monobenzone and the compounds levodopa and ivig have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and skin, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.⁶

Genetics Home Reference: Vitiligo is a condition that causes patchy changes in skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-20s, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.¹⁷

Wikipedia: Vitiligo (pron.: /ˌvɪtɨˈlaɪɡoʊ/) is a condition that causes depigmentation of sections of skin....⁴⁴ more...

Aliases & Descriptions:

vitiligo 6 17 8 33 32 23 43 vitiligo (disorder) 6

Diseases related to vitiligo by text searches and GeneDecks gene sharing:

(show top 50)    (show all 977)

id	Related Disease	Score	Top Affiliating Genes
1	systemic lupus erythematosus	29.9	FOXP3, FASLG, MBL2, PTPN22, CTLA4
2	hepatitis	29.0	XDH, GZMB, GSR, FASLG, FAS, IFNA2
3	microphthalmia	28.6	KIT, MPO, MLANA, MITF, MC1R, TYR
4	piebaldism	28.6	KIT, KITLG, CLEC11A, MITF, PDGFRA
5	vogt-koyanagi-harada disease	27.2	CD8A, ARMC9, IL17A, IL2RA, FASLG, FAS
6	autoimmune thyroiditis	27.1	CIITA, CD59, IL2RA, IL4, FASLG, FAS
7	hepatitis c	27.0	CIITA, GSR, IL10, IL4, FAS, CCR5
8	colorectal cancer	26.0	VDR, MSH2, MLH1, GSTM1, GSTP1, GSTT1
9	vaccinia	24.7	KITLG, CIITA, BAX, FURIN, CD8A, CD4
10	mycosis fungoides	24.0	KIT, CD4, MLANA, MLH1, GZMB, IL10
11	viral hepatitis	22.7	BAX, MPO, GSR, IL10, IL4, IL6
12	melanoma	20.6	KIT, KITLG, VDR, BMP6, BIRC5, PARP1
13	lichen planus	20.3	LPP, BAX, CD79A, CD4, GZMB, IL10
14	graves' disease	20.3	KITLG, BTNL2, VDR, BMP6, CIITA, BAX
15	psoriasis	19.9	KITLG, VDR, BIRC5, CIITA, BAX, MPO
16	blindness	19.4	VDR, XDH, MPO, CD79A, GSR, FGF2
17	nasopharyngitis	18.6	KIT, KITLG, VDR, BMP6, BIRC5, PARP1
18	lupus erythematosus	17.8	BTNL2, VDR, BMP6, PARP1, BCHE, CIITA
19	fibrosis	16.9	KIT, KITLG, LPO, VDR, BMP6, BIRC5
20	thyroiditis	16.4	PDE10A, KIT, KITLG, LPO, VDR, BMP6
21	neuronitis	15.5	PDE10A, KIT, KITLG, GCHFR, GCH1, VDR
22	hermansky-pudlak syndrome	14.4	GCH1, PAH, GSR, CAT, TYR, TYRP1
23	intraocular melanoma	14.3	CD59, CD46, MLANA, MITF, MC1R, MAGEA1
24	hyperphenylalaninemia	14.2	PCBD1, GCH1, PAH, QDPR, CAT, G6PD
25	oculocutaneous albinism	14.2	KIT, MITF, MC1R, TYR, TYRP1, DCT
26	tetrahydrobiopterin deficiency	14.2	PCBD1, GCH1, PAH, QDPR, TH, SOD1
27	senile cataract	14.2	GSR, GSTM1, GSTT1, FGF2, CAT, G6PD
28	diabetic cataract	14.1	GSR, CAT, G6PD, SOD1, CP
29	autoimmune disease 1	14.1	FOXD3, NLRP1, SLEV1
30	social phobia	14.1	MAOA, CAT, SOD1, NPY
31	perivascular epithelioid cell tumor	14.1	KIT, KITLG, MLANA, MITF, PMEL
32	phenylketonuria	14.1	PCBD1, PAH, QDPR, G6PD, TH
33	sepiapterin reductase deficiency	14.1	PCBD1, GCHFR, GCH1, QDPR, TH
34	post-traumatic stress disorder	14.1	MAOA, CAT, SOD1, NPY
35	phobia	14.1	MAOA, CAT, COMT, SOD1, NPY
36	juvenile xanthogranuloma	14.1	KIT, MLANA, TYR, PMEL
37	hypothyroidism, autoimmune	14.1	IL2RA, AIRE, TPO, CTLA4
38	hyperpigmentation of eyelid	14.0	KIT, KITLG, MITF, EDN1, TYR, TYRP1
39	drug dependence	14.0	MAOA, PNOC, OPRL1, SOD1, POMC, NPY
40	waardenburg's syndrome	14.0	KIT, MITF, TYR, TYRP1, POMC
41	posterior uveal melanoma	14.0	BIRC5, MLANA, MITF, TYR, TAP1
42	pigmentation disease	14.0	KIT, MITF, TYR
43	cor pulmonale	14.0	FGF2, CAT, LTA, EDN1, ACE, SOD1
44	tyrosinemia	14.0	PAH, QDPR, TYR, TAT
45	hypoparathyroidism	14.0	VDR, IL2RA, AIRE, TPO, PTPN22, CTLA4
46	postpartum depression	14.0	MAOA, TPO, PNOC, COMT
47	bilirubin metabolic disorder	14.0	GCH1, PAH, XDH, ACADS, ACHE, G6PD
48	orthostatic hypotension	13.9	MAOA, DDC, ACE, ACHE
49	gtp cyclohydrolase i deficiency	13.9	GCH1, QDPR, TH
50	postherpetic neuralgia	13.9	HLA-A, HLA-B, HLA-DRB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 methoxsalen, monobenzone, trioxsalen

MalaCards organs/tissues related to vitiligo:

²²

MGI Mouse Phenotypes related to vitiligo:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	TH, ACHE, PTPN22, IL10RB, FOXP1, FOXD3
2	endocrine/exocrine gland phenotype	MP:0005379	9.9	XDH, MITF, FASLG, IFNG, AIRE, DDR1
3	craniofacial phenotype	MP:0005382	9.8	MC1R, DDR1, NFE2L2, PDGFRA, EDN1, ACHE
4	pigmentation phenotype	MP:0001186	9.6	CTLA4, PDGFRA, TYR, TYRP1, DCT, POMC
5	renal/urinary system phenotype	MP:0005367	9.6	KIT, PCBD1, PAH, BAX, ASIP, AQP3
6	hematopoietic system phenotype	MP:0005397	9.3	IL17A, IL20RA, CCR6, HLA-C, HLA-DQA1, HLA-DQB1
7	embryogenesis phenotype	MP:0005380	9.2	TBP, COMT, PDGFRA, G6PD, TYR, CSF2
8	hearing/vestibular/ear phenotype	MP:0005377	9.2	MC1R, FAS, GPX1, CASP3, DDR1, EDN1
9	nervous system phenotype	MP:0003631	8.9	NFE2L2, PDGFRA, LTA, EDN1, ACHE, G6PD
10	liver/biliary system phenotype	MP:0005370	8.7	ATP8B1, FURIN, ASIP, IL10RB, IL6, CCR5
11	normal phenotype	MP:0002873	7.9	NR1H3, CTLA4, HLA-DQB1, AIRE, HMGCR, HUNK
12	no phenotypic analysis	MP:0003012	7.9	HLA-C, TP53, PTGS2, TBP, KLRD1, ACHE
13	adipose tissue phenotype	MP:0005375	7.8	ACE, ACHE, TGFBR2, CSF2, POMC, PMCH
14	digestive/alimentary phenotype	MP:0005381	7.5	NPY, PMS2, MLH1, IL17A, FBXO11, AQP3
15	skeleton phenotype	MP:0005390	7.5	F2RL1, CASP3, ESR1, TP53, PTGS2, DDR1
16	integument phenotype	MP:0010771	7.5	KIT, KITLG, FAS, IFNG, F2RL1, TP53
17	behavior/neurological phenotype	MP:0005386	7.4	ACE, ACADS, C12orf10, LTA, PDGFRA, COMT
18	immune system phenotype	MP:0005387	7.1	PMS2, POMC, GPX1, IFNG, ICA1, AIRE
19	growth/size phenotype	MP:0005378	7.1	KIT, IL6, FBXO11, AQP3, MC1R, MCHR1
20	reproductive system phenotype	MP:0005389	6.6	COMT, NR1H3, PTGS2, TNF, CASP3, PDGFRA
21	vision/eye phenotype	MP:0005391	6.5	PTGS2, TNF, TP53, AIRE, CASP3, IFNG
22	mortality/aging	MP:0010768	6.0	ZMIZ1, PARP1, BCHE, XDH, XBP1, MSH6
23	tumorigenesis	MP:0002006	5.5	KIT, ESR1, AIRE, TP53, TNF, PTGS2
24	muscle phenotype	MP:0005369	5.0	HLA-DQB1, TP53, TNF, PTGS2, NR1H3, PDGFRA
25	cardiovascular system phenotype	MP:0005385	4.5	KITLG, VDR, ZMIZ1, XBP1, FURIN, MPO
26	homeostasis/metabolism phenotype	MP:0005376	4.3	TSLP, TH, TG, TGFBR2, TF, OPRL1
27	cellular phenotype	MP:0005384	2.7	KIT, FOXD3, FOXP1, FOXP3, MLH1, ASIP

Articles related to vitiligo:

(show top 50)    (show all 234)

id	Title	Authors	Year	Affiliating Genes
1	Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of on set. (21326295)	Jin Y.... Spritz R.A.	2011	BTNL2, C6orf10
2	Heme oxygenase-1 expression protects melanocytes from stress-induced cell death: implications for vitiligo. (21426408)	Elassiuty Y.E.... Le Poole I.C.	2011	HMOX1
3	Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients. (21625016)	Esmaeili B.... Rafatpanah H.	2011	IL17A, MT-CO2
4	Genetic Variants of the DDR1 Gene Are Associated with Vitiligo in Two Independent Brazilian Population Samples. (20182441)	de Castro C.C.... Mira M.T.	2010	DDR1
5	Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entran ce of Myg1. (20377893)	Philips M.A.... KA/ks S.	2010	C12orf10
6	Dysfunction of glutathione S-transferase leads to exc ess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients. (20070240)	Kostyuk V.A.... Korkina L.G.	2010	GSTT1, GSTM1
7	First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with h alo nevi. (20370855)	van Geel N.A.... Lambert J.	2010	TYR, MLANA, PMEL
8	SMOC2 gene variant and the risk of vitiligo in Jordan ian Arabs. (20965805)	Alkhateeb A.... Qarqaz F.	2010	SMOC2
9	CTLA4 and generalized vitiligo: two genetic association studies and a meta-analysis of published data. (19175525)	Birlea S.A.... Spritz R.A.	2009	CTLA4
10	Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. (19543371)	Ren Y.... Zhang X.	2009	XBP1, HLA-DRB1
11	Fine-Mapping of Vitiligo Susceptibility Loci on Chrom osomes 7 and 9 and Interactions with NLRP1 (NALP1). (19727120)	Jin Y.... Spritz R.A.	2009	NLRP1
12	Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo. (19129082)	Pehlivan S.... Ozkinay C.	2009	ACE, CCR5, IL4
13	Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in chil dren]. (19861278)	Chen J.P.... Li J.	2009	MLANA
14	Protease-activated receptor-2 downregulation is assoc iated to vitiligo lesions. (19368691)	Moretti S.... Massi D.	2009	F2RL1
15	The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population. (18537816)	Guan C.P.... Hong W.S.	2008	NFE2L2
16	A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population. (19112571)	Li K.... Gao T.	2008	COMT
17	Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients. (18337837)	Adams S.... Bhardwaj N.	2008	TYR, DCT, MLANA
18	Vitiligo occurring at site of interferon-alpha 2b injection in a patient with chronic viral hepatitis C: a case report. (18498412)	Anbar T.S.... Ahmad H.M.	2008	IFNA2
19	Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population. (17568619)	Uhm Y.K.... Lee M.H.	2007	GSTT1, GSTM1
20	ssociation of HLA class I and II alleles with generalized vitiligo in Chinese Hans in north China (17407088)	Wang J.... Chen H.D.	2007	HLA-A, HLA-DQB1, HLA-DRB1
21	Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. (17637824)	Jin Y.... Spritz R.A.	2007	NLRP1
22	Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo. (16946714)	Spencer J.D.... Schallreuter K.U.	2007	POMC
23	Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo. (16528352)	Schallreuter K.U.... Anderson D.	2006	CAT
24	Enhanced survival associated with vitiligo expression during maintenance biotherapy for metastatic melanoma. (16946711)	Boasberg P.D.... O'Day S.J.	2006	DCT
25	Psoriasis confined strictly to vitiligo areas--a Koebner-like phenomenon? (16441627)	Berger T.G.... Simon M.	2006	TNF, IFNG
26	Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients. (16260696)	Luiten R.M.... de Gast G.C.	2005	MAGEA1, MLANA, PMEL
27	A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients. (16101862)	Hazneci E.... EA9refoA9lu M.	2005	SOD1, CAT
28	A novel linkage to generalized vitiligo on 4q13-q21 identified in a genomewide linkage analysis of Chinese families. (15809929)	Chen J.J.... Zhang X.J.	2005	AIS4
29	Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo. (16098053)	Alkhateeb A.... Spritz R.A.	2005	FOXD3, AIS1
30	Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)	de Vijlder H.C.... Claas F.H.	2004	HLA-DRB1, HLA-DRB4
31	Association of angiotensin converting enzyme gene I/D polymorphism of vitiligo in Korean population. (14717849)	Jin S.Y.... Lee M.H.	2004	ACE
32	VIT1 gene and vitiligo. (17642606)	Eapen B.R.	2004	FBXO11
33	Increased epidermal functioning wild-type p53 expression in vitiligo. (12823440)	Schallreuter K.U.... Fanghanel J.	2003	TP53, PRDX5
34	Sequential immunohistochemical study of depigmenting and repigmenting minigrafts in vitiligo. (14721774)	Abdallah M.... Orfanos C.E.	2003	CD8A
35	Vitiligo: complex segregation and linkage disequilibrium analyses with respect to microsatellite loci spanning the HLA. (11941482)	Arcos-Burgos M.... Palacio G.	2002	VTLG
36	Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo. (11511311)	Palermo B.... Giachino C.	2001	TYR, PMEL
37	Molecular mapping of epitopes on melanocyte-specific protein Pmel17 which are recognized by autoantibodies in patients with vitiligo. (11472416)	Kemp E.H.... Weetman A.P.	2001	PMEL
38	Increased basic fibroblast growth factor levels in serum and blister fluid from patients with vitiligo. (11243639)	Ozdemir M.... TA1zA1n Y.	2000	FGF2
39	Serum selenium levels and blood glutathione peroxidase activities in vitiligo. (10468804)	Beazley W.D.... Schallreuter K.U.	1999	CAT
40	The expression of alpha-MSH by melanocytes is reduced in vitiligo. (10816691)	Graham A.... Thody A.J.	1999	POMC
41	Anti-tyrosinase-related protein-2 immune response in vitiligo patients and melanoma patients receiving active-specific immunotherapy. (9856813)	Okamoto T.... Hoon D.S.	1998	DCT
42	Increased sensitivity to peroxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. (9284096)	Maresca V.... Picardo M.	1997	SOD1, CAT
43	Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo. (9118024)	Fishman P.... Shoenfeld Y.	1997	TYR
44	Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C. (9426968)	Nouri K.... Machler B.C.	1997	IFNA2
45	Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay. (9204957)	Kemp E.H.... Weetman A.P.	1997	TYR
46	Treatment of vitiligo with a topical application of p seudocatalase and calcium in combination with short-term UVB exposure: a case s tudy on 33 patients. (7599386)	Schallreuter K.U.... Levenig C.	1995	MAOA, CAT
47	The role of tyrosinase in autoimmune vitiligo. (7934446)	Song Y.H.... Maclaren N.	1994	TYR
48	Increased incidence of antismooth muscle antibody in Korean vitiligo patients. (8300936)	Hann S.K.... Park Y.K.	1993	TG
49	Nonsegmental vitiligo: decrease of the CD45RA+ T-cell subset and evidence for peripheral T-cell activation. (1587659)	Abdel-Naser M.B.... Orfanos C.E.	1992	CD8A
50	Age of onset in vitiligo: relationship with HLA supratypes. (1997215)	Finco O.... Rabbiosi G.	1991	C4B

Genes related to vitiligo according to GeneCards:

(show top 50)    (show all 168)

id	Symbol	Description	Score	GeneCards Section Context
1	FBXO11	F-box protein 11	11.1	Publications, Orthologs, Summaries, Aliases & Descriptions
2	VTLG	Vitiligo	11.0	Publications, Aliases & Descriptions
3	AIS3	autoimmune susceptibility 3 (vitiligo specific)	11.0	Publications, Aliases & Descriptions
4	SLEV1	systemic lupus erythematosus, vitiligo-related 1	11.0	Publications, Aliases & Descriptions
5	NLRP1	NLR family, pyrin domain containing 1	11.0	Publications
6	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
7	CAT	catalase	11.0	Publications
8	AIS2	autoimmune susceptibility 2	11.0	Publications
9	C12orf10	chromosome 12 open reading frame 10	11.0	Publications
10	PMEL	premelanosome protein	11.0	Publications
11	TYRP1	tyrosinase-related protein 1	11.0	Publications
12	PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	11.0	Publications
13	MCHR1	melanin-concentrating hormone receptor 1	11.0	Publications
14	MLANA	melan-A	11.0	Publications
15	TYR	tyrosinase (oculocutaneous albinism IA)	11.0	Publications
16	DCT	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)	11.0	Publications
17	QDPR	quinoid dihydropteridine reductase	11.0	Publications
18	CD8A	CD8a molecule	11.0	Publications
19	AIRE	autoimmune regulator	11.0	Publications
20	C4B	complement component 4B (Chido blood group)	11.0	Publications
21	GPX1	glutathione peroxidase 1	11.0	Publications
22	LPO	lactoperoxidase	11.0	Publications
23	PRDX5	peroxiredoxin 5	11.0	Publications
24	GCH1	GTP cyclohydrolase 1	11.0	Publications
25	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
26	PAH	phenylalanine hydroxylase	11.0	Publications
27	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
28	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
29	MAOA	monoamine oxidase A	11.0	Publications
30	KITLG	KIT ligand	11.0	Publications
31	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
32	MITF	microphthalmia-associated transcription factor	11.0	Publications
33	NPY	neuropeptide Y	11.0	Publications
34	SOD1	superoxide dismutase 1, soluble	11.0	Publications
35	BCHE	butyrylcholinesterase	11.0	Publications
36	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
37	GSR	glutathione reductase	11.0	Publications
38	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
39	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
40	POMC	proopiomelanocortin	11.0	Publications
41	TPO	thyroid peroxidase	11.0	Publications
42	XDH	xanthine dehydrogenase	11.0	Publications
43	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	11.0
44	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
45	AIS4	autoimmune disease, susceptibility to, 4	10.9	Publications
46	PRO2268	uncharacterized protein PRO2268	10.9	Publications
47	AIS1	autoimmune susceptibility 1	10.9	Publications
48	AIS	Adolescent idiopathic scoliosis	10.9	Publications
49	IDDM8	insulin-dependent diabetes mellitus 8	10.9	Publications
50	FOXD3	forkhead box D3	10.9	Publications

Pathways related to vitiligo according to GeneDecks:

(show top 50)    (show all 130)

id	Pathway	Score	Top Affiliating Genes
1	Tyrosine metabolism20	10.9	DCT, TAT, TH, TYRP1, TYR, COMT
2	Tyrosine metabolism p.1 (dopamine)41	10.8	COMT, TYR, TH, PNMT, DDC, MAOA
3	Tyrosine metabolism p.1 (dopamine)10	10.8	DDC, TH, COMT, MAOA, PAH, PNMT
4	Graft-versus-host disease20	10.6	HLA-C, HLA-B, HLA-A, KLRD1, HLA-DRB4, HLA-DRA
5	Antigen processing and presentation20	10.4	HLA-DRB4, KLRD1, TAP1, HLA-DRB1, CIITA, CD8A
6	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	GZMB, IL2RA, FASLG, CSF2
7	Lymphocyte Signaling3	10.3	GPX1, KITLG, KIT, HMOX1, FASLG, IL2RA
8	CTLA4 Signaling36	10.2	HLA-DRB4, HLA-DRA, HLA-DQA1, CD4, CTLA4, CD8A
9	CTL Mediated Apoptosis36	10.2	HLA-DQA1, HLA-C, HLA-B, HLA-A, CASP3, HLA-DRA
10	Jak-STAT signaling pathway20	10.1	IL10, IL19, IL20, IL20RA, IL22RA1, IL2RA
11	RAR-Gamma-RXR-Alpha Degradation36	10.1	TBP, IL20, CSF2, IL19, LTA
12	Immune response IL-22 signaling pathway10	10.1	CD4, IL22RA1, IL10RB, HLA-DQB1, HLA-DQA1, IL2RA
13	Phagosome20	10.0	MBL2, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TAP1
14	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	10.0	TP53, XDH, MSH2, MLH1, GPX1, CAT
15	Immune response_IL-22 signaling pathway41	10.0	HLA-DRB1, CD4, IL10RB, IL22RA1, IL2RA, HLA-DQA1
16	Asthma20	9.8	HLA-DRB4, IL10, IL4, HLA-DQA1, HLA-DQB1, TNF
17	NFAT in Immune Response36	9.6	HLA-DRB4, HGF, DDR1, PDGFRA, NUDT6, HLA-DRB1
18	Autoimmune thyroid disease20	9.5	HLA-DRA, TG, CTLA4, TPO, HLA-DRB4, HLA-DRB1
19	Viral myocarditis20	9.5	HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, HLA-DRB1, HLA-C
20	Immune System38	9.4	CCR6, CSF2, HGF, TAP1, KLRD1, NLRP1
21	Hematopoietic cell lineage20	9.3	IL2RA, IL4, IL6, HLA-DRA, CD59, HLA-DRB4
22	Type I diabetes mellitus20	9.0	HLA-DQA1, HLA-C, HLA-B, HLA-A, ICA1, IFNG
23	THC Differentiation Pathway36	8.9	HLA-DRB4, TNF, IL4, IL10, IL10RB, IL2RA
24	Endothelin-1 Signaling Pathway36	8.9	PDGFRA, IL20, EDN1, DDR1, CASP3, IL6
25	TGF-Beta Pathway36	8.8	BMP6, KITLG, IL2RA, IL20, IL19, IL10RB
26	Rheumatoid arthritis20	8.8	TNF, IFNG, IL17A, IL6, CTLA4, HLA-DQA1
27	Apoptotic Pathways in Synovial Fibroblasts36	8.7	HGF, TP53, IL2RA, NUDT6, LTA, PDGFRA
28	Pathways in cancer20	8.6	BIRC5, HGF, TGFBR2, BAX, MSH2, MSH6
29	Allograft rejection20	8.6	TNF, GZMB, HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1
30	Toxoplasmosis20	8.5	HLA-DRB4, TNF, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1
31	MAPK Family Pathway36	8.5	IL22RA1, IL20RA, IL20, IL19, IL10RB, IL2RA
32	Molecular Mechanisms of Cancer36	8.5	BAX, PDGFRA, HGF, NUDT6, TGFBR2, BMP6
33	Natural killer cell mediated cytotoxicity20	8.5	IFNA2, TNF, FASLG, CSF2, KLRD1, FAS
34	Influenza A20	8.5	TNF, HLA-DRB4, HLA-DRA, CIITA, HLA-DQA1, HLA-DRB1
35	Tec Kinases Signaling36	8.5	HGF, NUDT6, PDGFRA, BMP6, BAX, CD4
36	Leishmaniasis20	8.4	HLA-DQB1, TNF, IL10, IL4, IFNG, PTGS2
37	p53 Mediated Apoptosis36	8.4	FGF2, IL2RA, IL6, CASP3, PDGFRA, HGF
38	Akt Signaling36	8.4	NUDT6, IL6, HGF, CCR5, TNF, DDR1
39	MIF Regulation of Innate Immune Cells36	8.3	LTA, PTGS2, CSF2, BMP6, BAX, IL10
40	STAT3 Pathway36	8.3	CSF2, IL19, IL20, IL22RA1, IL6, IL2RA
41	MIF Mediated Glucocorticoid Regulation36	8.3	IL6, HGF, CSF2, BMP6, BAX, IL10
42	all-trans-Retinoic Acid Signaling in Brain36	8.2	IL6, IL4, IL20, IL19, TNF, BAX
43	PAK Pathway36	8.2	IL20, TNF, PDGFRA, HGF, LTA, NUDT6
44	Antioxidant Action of Vitamin-C36	8.1	BMP6, CCR6, CCR5, TNF, LTA, NUDT6
45	Cellular Apoptosis Pathway36	8.0	NUDT6, PDGFRA, TNF, TP53, CASP3, KITLG
46	Tuberculosis20	7.9	VDR, HLA-DQB1, HLA-DQA1, CASP3, IFNG, IFNA2
47	JAK-STAT Pathway36	7.8	NUDT6, IL2RA, IL10RB, IL19, HGF, IL20
48	Cytokine-cytokine receptor interaction20	7.4	IL22RA1, IL2RA, IL4, IL6, FASLG, FAS
49	p38 Signaling36	7.3	PDGFRA, CSF2, IL10RB, CCR6, IL6, IL4
50	Colorectal Cancer Metastasis36	6.7	PTGS2, TNF, CASP3, IFNG, IL6, MLH1

Compounds related to vitiligo according to GeneDecks:

(show top 50)    (show all 449)

id	Compound	Score	Top Affiliating Genes
1	levodopa32 9 9	12.9	KITLG, GCH1, PAH, QDPR, MC1R, MAOA
2	ivig32	10.2	FASLG, CCR5, LTA, TG, CSF2
3	h2o232	9.9	KITLG, PCBD1, GCHFR, GCH1, LPO, PAH
4	aspartate32	9.9	VDR, BMP6, PAH, FURIN, GZMB, GSR
5	epinephrine32 9 18 9	12.7	KITLG, GCH1, LPO, BMP6, PAH, CD79A
6	dopamine32 9 18 9	12.6	GCH1, BMP6, PAH, CIITA, CD79A, GSTP1
7	ascorbic acid32 18	10.6	GCH1, LPO, VDR, GSTM1, GSTP1, GSTT1
8	adenylate32	9.5	KITLG, VDR, FURIN, GSR, GSTP1, IL1RN
9	heparin32 9 18 9	12.5	KITLG, BCHE, FURIN, MPO, CD79A, CD4
10	arginine32	9.5	GCH1, LPO, VDR, PAH, BCHE, XDH
11	n acetylcysteine32	9.4	BIRC5, CD79A, IL2RA, HMGCR, TP53, NFE2L2
12	thyroxine32 18	10.4	LPO, VDR, CIITA, CD79A, GSR, FGF2
13	iron32 18	10.4	KITLG, LPO, PAH, XDH, FURIN, MPO
14	tetrahydrobiopterin32 9 18 9	12.3	PCBD1, GCHFR, GCH1, PAH, XDH, QDPR
15	folate32	9.3	GCH1, VDR, PAH, QDPR, CD79A, MLH1
16	pge232	9.2	CIITA, MT-CO2, CD4, FOXP3, GSR, FGF2
17	glutamate32	9.1	VDR, BMP6, BCHE, MSH2, CD79A, CD4
18	estrogen32	8.9	PCBD1, GCH1, VDR, XBP1, FURIN, MLH1
19	melphalan32 9 9	10.8	BIRC5, CD79A, GSTP1, IL4, IFNA2, IFNG
20	superoxide32 18	9.7	KITLG, GCH1, LPO, BIRC5, CLEC11A, XDH
21	norepinephrine32 9 18 9	11.7	KITLG, GCH1, LPO, BMP6, PAH, BCHE
22	cyclosporin a32 42	9.7	KITLG, VDR, CIITA, CD59, CD46, FOXP3
23	agarose32	8.7	KIT, KITLG, PARP1, BAX, MLH1, GZMB
24	creatinine32	8.6	KITLG, PCBD1, VDR, BMP6, BCHE, MPO
25	histamine32 18	9.6	KIT, KITLG, BMP6, MPO, CD79A, IL1RN
26	ly29400232	8.6	GZMB, FGF2, IL10, IL17A, IL4, IL6
27	oxygen32 18	9.5	KITLG, GCH1, LPO, BIRC5, PARP1, PAH
28	4-hydroxynonenal32 18	9.4	PARP1, BAX, XDH, MPO, GSR, GSTM1
29	aspirin32 34 18	10.1	KITLG, VDR, BMP6, BIRC5, BCHE, CD79A
30	nitric oxide32 9 18 9	11.1	KIT, KITLG, GCHFR, GCH1, LPO, BMP6
31	tyrosine32	7.8	KIT, KITLG, GCH1, LPO, BMP6, BIRC5
32	rantes32	7.8	KITLG, BMP6, CIITA, CD4, CD46, GZMB
33	sb 20358032 42	8.6	VDR, BMP6, BIRC5, PARP1, FGF2, IL17A
34	doxorubicin32 34 9 9	10.4	KIT, KITLG, LPO, BMP6, PARP1, MSH2
35	vitamin d32	7.4	VDR, BMP6, PAH, XBP1, CD79A, GSTM1
36	cysteine32	7.4	LPO, VDR, PARP1, PAH, XDH, MSRA
37	prednisolone32 9 9	9.2	KITLG, BMP6, MPO, CD79A, GZMB, GSTM1
38	neopterin32	7.1	GCH1, PAH, QDPR, CD79A, CD4, GZMB
39	methotrexate32 34 42 9 9	11.1	KIT, KITLG, BMP6, BIRC5, QDPR, CD79A
40	pdtc32	7.1	BIRC5, PARP1, XDH, IL4, IL6, IFNG
41	serine32	7.0	KIT, KITLG, GCH1, VDR, BMP6, BIRC5
42	lactate32	6.9	KIT, KITLG, LPO, BMP6, BIRC5, BCHE
43	vegf32	6.8	KIT, KITLG, CLEC11A, PARP1, XBP1, MPO
44	paraffin32	6.6	KIT, KITLG, BIRC5, BAX, MSH2, MSH6
45	indomethacin32 9 9	8.4	BMP6, BIRC5, MPO, CD79A, GSR, IL17A
46	thymidine32 18	7.1	KIT, KITLG, VDR, BMP6, BIRC5, CIITA
47	dexamethasone32 42 34 9 9	9.6	KITLG, VDR, BMP6, BIRC5, PARP1, CIITA
48	genistein32 9 18 9	8.5	KITLG, VDR, BIRC5, PARP1, BAX, CD4
49	actinomycin d32	4.6	KIT, KITLG, VDR, BIRC5, PARP1, CIITA
50	cycloheximide32	4.2	KIT, KITLG, VDR, BMP6, BIRC5, PARP1

Cellular components related to vitiligo according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:042470	10.7	GCHFR, RAB5B, MLANA, TYR, TYRP1, DCT
2	melanosome membrane	GO:033162	10.5	DCT, TH, TYRP1, TYR
3	clathrin-coated endocytic vesicle membrane	GO:030669	10.5	TYRP1, HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.4	HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-C
5	ER to Golgi transport vesicle membrane	GO:012507	10.4	HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-C
6	MHC class II protein complex	GO:042613	10.4	HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
7	transport vesicle membrane	GO:030658	10.3	HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, ICA1
8	trans-Golgi network membrane	GO:032588	10.0	HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
9	integral to plasma membrane	GO:005887	9.5	HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB4, TPO, TNF
10	cytosol	GO:005829	8.5	COMT, NLRP1, PNMT, DDC, TP53, HMOX1
11	external side of plasma membrane	GO:009897	8.3	IFNG, HLA-DRB1, HLA-DRB4, TNF, CTLA4, ACE
12	extracellular region	GO:005576	8.2	TG, ACHE, C4B, EDN1, RNASET2, PNOC
13	plasma membrane	GO:005886	7.7	TNF, TPO, HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1
14	extracellular space	GO:005615	7.1	HGF, HMOX1, TNF, LTA, C1QTNF6, EDN1

Biological processes related to vitiligo according to GeneDecks:

(show all 47)

id	Name	GO ID	Score	Top Affiliating Genes
1	melanin biosynthetic process	GO:042438	10.9	TYRP1, PMEL, MC1R, ASIP
2	cellular nitrogen compound metabolic process	GO:034641	10.9	POMC, PSMB8, PSMB9, TAT, TH, PNMT
3	hydrogen peroxide catabolic process	GO:042744	10.9	PRDX5, TPO, CAT, GPX1, MPO, LPO
4	L-phenylalanine catabolic process	GO:006559	10.9	TAT, QDPR, PAH, PCBD1
5	catecholamine biosynthetic process	GO:042423	10.9	TH, PNMT, DDC, PAH
6	detection of bacterium	GO:016045	10.6	HLA-A, HLA-B, HLA-DRB1, HLA-DRB4
7	neurotransmitter biosynthetic process	GO:042136	10.6	TH, ACHE, COMT, MAOA, PAH
8	glutathione metabolic process	GO:006749	10.6	SOD1, G6PD, GPX1, GSTT1, GSTP1, GSR
9	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.6	HLA-DRB4, HLA-DRB1, HLA-DQB1
10	germ cell programmed cell death	GO:035234	10.6	BAX, KITLG, KIT
11	pigmentation	GO:043473	10.5	TH, C12orf10, MC1R, KIT
12	embryonic hemopoiesis	GO:035162	10.5	TGFBR2, TPO, KITLG, KIT
13	elevation of cytosolic calcium ion concentration	GO:007204	10.4	PMCH, OPRL1, EDN1, PDGFRA, F2RL1, CCR5
14	T cell costimulation	GO:031295	10.4	CTLA4, HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
15	T cell receptor signaling pathway	GO:050852	10.4	PTPN22, HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
16	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.4	HGF, PDGFRA, CAT, F2RL1, KIT
17	dopamine biosynthetic process	GO:042416	10.3	GCH1, DDC, TH
18	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.3	HLA-DRB4, HLA-DRB1, HLA-DQB1
19	regulation of blood pressure	GO:008217	10.3	POMC, SOD1, ACE, PTGS2, HMOX1, GCH1
20	positive regulation of phospholipase C activity	GO:010863	10.3	KIT, FGF2, PDGFRA
21	tetrahydrobiopterin biosynthetic process	GO:006729	10.3	QDPR, GCH1, PCBD1
22	protein tetramerization	GO:051262	10.0	ACHE, TP53, HLA-DRB4, HLA-DRB1, HMGCR, CAT
23	transformed cell apoptotic process	GO:006927	9.9	TNF, FAS, BAX
24	response to oxidative stress	GO:006979	9.8	PRDX5, TAT, PTGS2, HMOX1, MBL2, MPO
25	small molecule metabolic process	GO:044281	9.8	ACADS, COMT, PNMT, DDC, PTGS2, ACHE
26	induction of apoptosis via death domain receptors	GO:008625	9.8	TNF, CASP3, FAS, FASLG
27	interferon-gamma-mediated signaling pathway	GO:060333	9.8	HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-DQA1, HLA-C
28	positive regulation of interleukin-23 production	GO:032747	9.7	CSF2, IFNG, IL17A
29	neuron apoptotic process	GO:051402	9.7	NLRP1, TP53, CASP3, FAS, BAX
30	induction of apoptosis	GO:006917	9.6	LTA, NLRP1, TNF, CASP3, IFNA2, FAS
31	virus-host interaction	GO:019048	9.6	PSMB8, PSMB9, PDGFRA, TBP, TP53, HLA-C
32	positive regulation of MHC class II biosynthetic process	GO:045348	9.5	CIITA, IL10, IL4, IFNG
33	immune response	GO:006955	9.5	CSF2, AIRE, HLA-A, HLA-B, HLA-C, HLA-DQA1
34	positive regulation of chemokine biosynthetic process	GO:045080	9.4	TNF, HMOX1, IFNG, IL4
35	negative regulation of growth of symbiont in host	GO:044130	9.2	LTA, TNF, IFNG, MBL2, IL10
36	anti-apoptosis	GO:006916	9.2	HGF, SOD1, TNF, TXNDC5, HMOX1, GPX1
37	humoral immune response	GO:006959	9.1	IL6, CCR6, IFNG, AIRE, TNF, LTA
38	signal transduction	GO:007165	9.1	HUNK, ESR1, HLA-DRB4, SMOC2, PNOC, LTA
39	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	EDN1, PTGS2, TNF, HMOX1, IL6
40	cytokine-mediated signaling pathway	GO:019221	9.1	HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, PSMB8
41	cell surface receptor signaling pathway	GO:007166	9.0	EDN1, KLRD1, IFNG, IFNA2, CCR5, IL2RA
42	response to glucocorticoid stimulus	GO:051384	8.9	TAT, ACADS, PTGS2, TNF, FAS, IL6
43	inflammatory response	GO:006954	8.6	PRDX5, C4B, PTGS2, TNF, F2RL1, IFNA2
44	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	EDN1, PTGS2, TNF, ESR1, IFNG
45	response to drug	GO:042493	7.8	PTGS2, COMT, LTA, EDN1, TGFBR2, SOD1
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	IFNG, F2RL1, ESR1, AIRE, TP53, TNF
47	apoptotic process	GO:006915	7.6	IFNG, CASP3, TP53, TNF, TGFBR2, PSMB9

Molecular functions related to vitiligo according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	amino acid binding	GO:016597	10.5	GCHFR, PAH, DDC, TAT
2	MHC class II receptor activity	GO:032395	10.4	HLA-DRB4, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
3	receptor binding	GO:005102	10.0	NPY, POMC, PRDX5, LTA, HLA-B, HLA-A
4	copper ion binding	GO:005507	9.9	CP, SOD1, DCT, TYRP1, TYR, TP53
5	peroxidase activity	GO:004601	9.9	PRDX5, PTGS2, TPO, MPO, LPO
6	growth factor activity	GO:008083	9.1	HGF, CSF2, NUDT6, IL6, IL4, IL10
7	protein homodimerization activity	GO:042803	8.9	CAT, HMOX1, HMGCR, PTGS2, PDGFRA, ACHE
8	enzyme binding	GO:019899	8.3	HMOX1, TP53, PTGS2, NLRP1, ESR1, CAT
9	cytokine activity	GO:005125	7.7	KITLG, CSF2, TSLP, EDN1, LTA, TNF
10	protein binding	GO:005515	5.2	TP53, TNF, PTPN22, TBP, DDC, DDR1