MCID: VGT001
MIFTS: 55

Vogt-Koyanagi-Harada Disease malady

Categories: Rare diseases, Neuronal diseases, Eye diseases, Immune diseases

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

Aliases & Descriptions for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 50 56 52 14
Uveomeningoencephalitic Syndrome 12 42 69
Uveomenigitic Syndrome 50 56
Vogt-Koyanagi-Harada Syndrome 50
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 50
Vkh Disease 50

Characteristics:

Orphanet epidemiological data:

56
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:12297
ICD10 33 H20.82 H30.81
ICD9CM 35 363.22 364.24
MeSH 42 D014607
NCIt 47 C85218
Orphanet 56 ORPHA3437
ICD10 via Orphanet 34 H20.8 H30.8
UMLS 69 C0042170

Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : 50 vogt-koyanagi-harada disease (vkh disease) is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin. melanin is the substance that gives skin, hair, and eyes their color. melanin is also found in the retina, where it plays a role in normal vision. people with vkh disease usually develop vision and hearing disturbances first, followed by signs of skin problems. the most common symptoms include headaches, panuveitis, vitiligo, hair loss (alopecia), and inner ear disturbances. neurological symptoms may also occur. the exact cause of vkh disease is not well understood, but research suggests it is an autoimmune disease. it is more common in people with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. the disease is treated with corticosteroids and other medications. last updated: 9/2/2016

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to hepatitis and alezzandrini syndrome, and has symptoms including cataract, sensorineural hearing impairment and visual impairment. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are Increased shRNA abundance (Z-score > 2) and endocrine/exocrine gland

Disease Ontology : 12 A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.8 HLA-A HLA-B HLA-C HLA-DRB1
2 alezzandrini syndrome 11.4
3 choroiditis 10.9
4 retinitis 10.7
5 uveitis 10.6
6 retinal detachment 10.5
7 hepatitis c 10.5
8 headache 10.5
9 sympathetic ophthalmia 10.4
10 scleritis 10.4
11 alopecia 10.3
12 neuropathy 10.3
13 lymphoma 10.3
14 posterior scleritis 10.3
15 melanoma 10.3
16 acute posterior multifocal placoid pigment epitheliopathy 10.3
17 central serous chorioretinopathy 10.3
18 solid pseudopapillary carcinoma of pancreas 10.3 HLA-A HLA-B
19 hemoglobin d disease 10.3 HLA-DQB1 HLA-DRB1
20 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.3 HLA-A HLA-B
21 complement component 8 deficiency 10.3 HLA-DRB1 PTPN22
22 mirizzi syndrome 10.3 HLA-B HLA-DRB1
23 bilateral parasagittal parieto-occipital polymicrogyria 10.3 HLA-DQB1 HLA-DRB1
24 cerebral sarcoidosis 10.3 HLA-A HLA-DRB1 IL2RA
25 lin-gettig syndrome 10.3 HLA-DQB1 HLA-DRB1
26 sacral nerve root cysts 10.3 HLA-A HLA-B HLA-DRB1
27 cataract 10.2
28 optic neuritis 10.2
29 macular holes 10.2
30 leukemia 10.2
31 neuritis 10.2
32 psoriasis 10.2
33 meningitis 10.2
34 meningoencephalitis 10.2
35 hernia of ovary and fallopian tube 10.2 HLA-A HLA-B HLA-DRB1
36 hashimoto's encephalitis 10.2 HLA-DRB1 PMEL TYR
37 rete testis adenocarcinoma 10.2 HLA-A HLA-DQB1
38 nystagmus, congenital motor, autosomal recessive 10.2 HLA-A HLA-B HLA-DRB1
39 patau syndrome 10.2 HLA-A HLA-DRB1 PTPN22
40 acanthoma 10.2 HLA-A HLA-B HLA-DRB1
41 immune deficiency, familial variable 10.2 HLA-B HLA-DQB1 HLA-DRB1
42 periodontosis 10.2 HLA-A IL2RA PTPN22
43 cervical adenoid basal carcinoma 10.2 HLA-B HLA-DQB1 HLA-DRB1
44 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.2 IL2RA TLR3
45 craniosynostosis 6 10.2 PMEL TYR TYRP1
46 respiratory system disease 10.2 HLA-B HLA-DRB1 IL2RA
47 neonatal antiphospholipid syndrome 10.2 HLA-DQB1 HLA-DRB1 IL17A
48 demyelinating disease 10.2 PMEL TYR
49 disease of mental health 10.2 HLA-B HLA-DRB1 IL17A
50 intracranial hemorrhage in brain cerebrovascular malformations 10.2 HLA-DRB1 IL2RA PTPN22

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease

Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

56 32 (show all 14)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cataract 56 32 Frequent (79-30%) HP:0000518
2 sensorineural hearing impairment 56 32 Very frequent (99-80%) HP:0000407
3 visual impairment 56 32 Frequent (79-30%) HP:0000505
4 short stature 56 32 Frequent (79-30%) HP:0004322
5 cognitive impairment 56 32 Very frequent (99-80%) HP:0100543
6 vitiligo 56 32 Very frequent (99-80%) HP:0001045
7 hypopigmented skin patches 56 32 Very frequent (99-80%) HP:0001053
8 abnormality of the eyelashes 56 32 Very frequent (99-80%) HP:0000499
9 abnormality of the eyebrow 56 32 Very frequent (99-80%) HP:0000534
10 premature graying of hair 56 32 Very frequent (99-80%) HP:0002216
11 glaucoma 56 32 Frequent (79-30%) HP:0000501
12 retinal detachment 56 32 Frequent (79-30%) HP:0000541
13 sparse scalp hair 56 32 Very frequent (99-80%) HP:0002209
14 poliosis 56 32 Very frequent (99-80%) HP:0002290

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.84 HLA-C HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.84 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.84 HLA-A HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.84 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.84 HLA-C HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.84 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.84 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.84 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.84 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.84 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.84 HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.84 HLA-C HLA-A HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.84 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.84 IFNA2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.84 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.84 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.84 HLA-C HLA-A HLA-B IFNA2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.84 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.84 HLA-C HLA-A IL2RA HLA-B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.84 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.84 HLA-C IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.84 IL2RA IFNA2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.84 IFNA2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.84 HLA-C HLA-A HLA-B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.84 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.84 HLA-C
27 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.84 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.84 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.84 IL2RA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.84 HLA-C HLA-A HLA-B
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.84 HLA-C HLA-A HLA-B
32 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.84 IL2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.84 HLA-C
34 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 FAS HLA-DQB1 IL17A IL2RA NLRP1 PMEL
35 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 FAS HLA-DQB1 IL17A IL2RA NLRP1 PMEL

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 CD8A FAS HLA-DQB1 IL17A IL2RA PTPN22
2 hematopoietic system MP:0005397 9.65 TGFBR3 TLR3 CD8A FAS HLA-DQB1 IL17A
3 immune system MP:0005387 9.32 CD8A FAS HLA-DQB1 IL17A IL2RA NLRP1

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 3
3 Angiogenesis Modulating Agents Phase 3
4
Cyclosporine Approved, Investigational, Vet_approved 79217-60-0, 59865-13-3 5284373 6435893
5
Mycophenolic acid Approved 24280-93-1 446541
6
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
7
Azathioprine Approved 446-86-6 2265
8
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
9
Povidone-iodine Approved 25655-41-8
10
Iodine 7553-56-2 807
11 cadexomer iodine
12 Dermatologic Agents
13 Anti-Bacterial Agents
14 Povidone
15 Anti-Infective Agents
16 Immunosuppressive Agents
17 Antifungal Agents
18 Antibiotics, Antitubercular
19 Antirheumatic Agents
20 Calcineurin Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3
2 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2
3 Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study Unknown status NCT02015351

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

39
Eye, Skin, Retina, T Cells, Liver, Ovary, Spinal Cord

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 354)
id Title Authors Year
1
Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging. ( 28091938 )
2017
2
Detection of Asymptomatic Choroiditis by Fundus Examination in Vogt-Koyanagi-Harada Disease. ( 27379469 )
2016
3
Optical Intensities of Different Compartments of Subretinal Fluid in Acute Vogt-Koyanagi-Harada Disease. ( 26871896 )
2016
4
Comparison of Enhanced Depth Imaging and Swept Source Optical Coherence Tomography in Assessment of Choroidal Thickness in Vogt-Koyanagi-Harada Disease. ( 27070488 )
2016
5
Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment. ( 26875727 )
2016
6
Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy. ( 27079805 )
2016
7
Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression. ( 27525196 )
2016
8
The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease. ( 27048179 )
2016
9
FEATURES OF OPTICAL COHERENCE TOMOGRAPHY FOR THE DIAGNOSIS OF VOGT-KOYANAGI-HARADA DISEASE. ( 27145255 )
2016
10
Juvenile Vogt-Koyanagi-Harada Disease in Which Good Visual Prognosis Was Derived from Swift and Definitive Diagnosis. ( 27110416 )
2016
11
Incidence and Management of Glaucoma in Vogt Koyanagi Harada Disease. ( 26967258 )
2016
12
SUB-TENON TRIAMCINOLONE ACETONIDE INJECTION IN A PREGNANT PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE. ( 28033228 )
2016
13
Mycophenolate mofetil combined with systemic corticosteroids prevents progression to chronic recurrent inflammation and development of 'sunset glow fundus' in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease. ( 27535102 )
2016
14
Adalimumab Treatment in Patients with Vogt-Koyanagi-Harada Disease. ( 27775450 )
2016
15
Topical difluprednate for treatment of serous retinal detachment and panuveitis associated with Vogt-Koyanagi-Harada disease. ( 27582676 )
2016
16
Point-of-Care Ultrasound Diagnosis of Bilateral Retinal Detachment Associated With Vogt-Koyanagi-Harada Disease in the Pediatric Emergency Department. ( 26890299 )
2016
17
Vogt-Koyanagi-Harada disease. ( 27241814 )
2016
18
The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt-Koyanagi-Harada Disease. ( 27440118 )
2016
19
FLUOCINOLONE ACETONIDE IMPLANT FOR VOGT-KOYANAGI-HARADA DISEASE: Three-Year Outcomes of Efficacy and Safety. ( 27333235 )
2016
20
Response to comment on: Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment. ( 27084083 )
2016
21
Outcomes of Trabeculectomy With Mitomycin-C in Uveitis Associated With Vogt-Koyanagi-Harada Disease. ( 26900830 )
2016
22
Reappraisal of the management of Vogt-Koyanagi-Harada disease: sunset glow fundus is no more a fatality. ( 27844182 )
2016
23
Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment. ( 26847039 )
2016
24
KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease. ( 27490240 )
2016
25
Fundus autofluorescence as a marker of disease severity in Vogt-Koyanagi-Harada disease. ( 27368955 )
2016
26
Changes of choroidal structure after corticosteroid treatment in eyes with Vogt-Koyanagi-Harada disease. ( 26906951 )
2016
27
Vogt-Koyanagi-Harada disease following BCG vaccination and tuberculosis. ( 27247899 )
2016
28
Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population. ( 27046676 )
2016
29
Outcomes of Vogt-Koyanagi-Harada Disease: A Subanalysis From a Randomized Clinical Trial of Antimetabolite Therapies. ( 27296490 )
2016
30
Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. ( 27008848 )
2016
31
Comment on: Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment. ( 27084081 )
2016
32
Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity. ( 27003480 )
2016
33
A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt-Koyanagi-Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy. ( 27652046 )
2016
34
Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease. ( 26671509 )
2016
35
Enhanced Depth SD-OCT Images Reveal Characteristic Choroidal Changes in Patients With Vogt-Koyanagi-Harada Disease. ( 27842195 )
2016
36
Surgical Treatment of Subretinal Fibrosis Caused Macular Detachment in Vogt-Koyanagi-Harada Disease: A Pioneer Study. ( 27494778 )
2016
37
Successful Treatment of Vitiligo Associated with Vogt-Koyanagi-Harada Disease. ( 27981622 )
2016
38
Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease. ( 26261230 )
2015
39
En Face Optical Coherence Tomography Imaging of the Choroid in a Case with Central Serous Chorioretinopathy during the Course of Vogt-Koyanagi-Harada Disease: A Case Report. ( 26955354 )
2015
40
RETINAL PIGMENT EPITHELIUM UNDULATIONS IN ACUTE STAGE OF VOGT-KOYANAGI-HARADA DISEASE: Biomarker for Functional Outcomes After High-Dose Steroid Therapy. ( 26352553 )
2015
41
Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study. ( 26301103 )
2015
42
Late posterior segment relapses in a series of Vogt-Koyanagi-Harada disease. ( 25604241 )
2015
43
Vogt-Koyanagi-Harada disease in three-year-old boy. ( 25711345 )
2015
44
Vogt-Koyanagi-Harada disease. ( 26448042 )
2015
45
Analysis of choroidal folds in acute Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography. ( 25663475 )
2015
46
TLR3 and TLR4 But not TLR2 are Involved in Vogt-Koyanagi- Harada Disease by Triggering Proinflammatory Cytokines Production Through Promoting the Production of Mitochondrial Reactive Oxygen Species. ( 26238371 )
2015
47
Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with Vogt-Koyanagi-Harada disease. ( 25565265 )
2015
48
Posterior subtenon triamcinolone acetonide injection as a primary treatment in eyes with acute Vogt-Koyanagi-Harada disease. ( 25792626 )
2015
49
DETECTION OF CHOROIDAL FOLDS IN PATIENTS WITH VOGT-KOYANAGI-HARADA DISEASE BY RETROMODE SCANNING LASER OPHTHALMOSCOPY. ( 26444520 )
2015
50
SUBFOVEAL CHOROIDAL THICKNESS IN PAPILLITIS TYPE OF VOGT-KOYANAGI-HARADA DISEASE AND IDIOPATHIC OPTIC NEURITIS. ( 26509220 )
2015

Variations for Vogt-Koyanagi-Harada Disease

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD8A HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
2
Show member pathways
13.34 CD8A HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
3
Show member pathways
13.25 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 IFNA2
4
Show member pathways
12.48 HLA-DQB1 HLA-DRB1 IL17A IL2RA
5
Show member pathways
12.43 FAS HLA-A HLA-B HLA-C IFNA2
6
Show member pathways
12.37 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 IFNA2
7
Show member pathways
12.36 CD8A HLA-A HLA-B HLA-C
8 12.31 HLA-A HLA-B HLA-C IL2RA
9 12.3 CD8A FAS IL17A IL2RA NLRP1 PTPN22
10
Show member pathways
12.3 FAS HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
11 12.21 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 IL2RA
12 12.18 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
13
Show member pathways
12.06 CD8A FAS HLA-A HLA-B HLA-C HLA-DQB1
14 12.01 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15 12 CD8A HLA-A HLA-B HLA-C
16
Show member pathways
11.98 HLA-A HLA-B HLA-C IFNA2 IL17A
17 11.88 CD8A IFNA2 IL2RA
18
Show member pathways
11.88 CD8A HLA-A HLA-DRB1 IL2RA
19
Show member pathways
11.85 HLA-DQB1 HLA-DRB1 PTPN22
20
Show member pathways
11.84 CD8A HLA-A HLA-DRB1
21
Show member pathways
11.81 IL17A TGFBR3 TLR3
22 11.79 CD8A HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
23 11.78 CD8A HLA-DQB1 HLA-DRB1 IL2RA
24 11.74 HLA-DQB1 HLA-DRB1 IL17A
25 11.67 CD8A IL17A IL2RA
26 11.61 CD8A HLA-DQB1 HLA-DRB1 PTPN22
27
Show member pathways
11.55 CD8A HLA-A IL2RA
28 11.08 HLA-A HLA-B HLA-C
29 10.27 TYR TYRP1

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.85 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TLR3
2 endosome membrane GO:0010008 9.78 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
3 early endosome membrane GO:0031901 9.73 HLA-A HLA-B HLA-C
4 external side of plasma membrane GO:0009897 9.73 CD8A FAS HLA-DRB1 IL17A IL2RA TGFBR3
5 melanosome GO:0042470 9.71 PMEL TYR TYRP1
6 phagocytic vesicle membrane GO:0030670 9.67 HLA-A HLA-B HLA-C
7 recycling endosome membrane GO:0055038 9.63 HLA-A HLA-B HLA-C
8 cell surface GO:0009986 9.61 CD8A FAS HLA-A HLA-B HLA-C HLA-DRB1
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.58 HLA-DQB1 HLA-DRB1 TYRP1
10 MHC class II protein complex GO:0042613 9.55 HLA-DQB1 HLA-DRB1
11 ER to Golgi transport vesicle membrane GO:0012507 9.55 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
12 melanosome membrane GO:0033162 9.52 TYR TYRP1
13 MHC class I protein complex GO:0042612 9.5 HLA-A HLA-B HLA-C
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15 integral component of membrane GO:0016021 10.25 CD8A FAS HLA-A HLA-B HLA-C HLA-DQB1
16 integral component of plasma membrane GO:0005887 10.05 CD8A FAS HLA-A HLA-B PMEL TGFBR3

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.95 HLA-A HLA-B HLA-C HLA-DRB1 NLRP1
2 inflammatory response GO:0006954 9.91 FAS IFNA2 IL17A IL2RA NLRP1 TLR3
3 regulation of immune response GO:0050776 9.86 CD8A HLA-A HLA-B HLA-C
4 immune system process GO:0002376 9.81 CD8A HLA-A HLA-B HLA-C HLA-DRB1 IL2RA
5 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.74 HLA-A HLA-B HLA-C
6 type I interferon signaling pathway GO:0060337 9.71 HLA-A HLA-B HLA-C IFNA2
7 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
8 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.63 HLA-A HLA-B HLA-C
9 melanosome organization GO:0032438 9.59 PMEL TYRP1
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.58 HLA-DQB1 HLA-DRB1
11 inflammatory response to antigenic stimulus GO:0002437 9.58 HLA-DRB1 IL2RA
12 necroptotic signaling pathway GO:0097527 9.54 FAS TLR3
13 melanin biosynthetic process GO:0042438 9.54 PMEL TYR TYRP1
14 activation-induced cell death of T cells GO:0006924 9.52 FAS IL2RA
15 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.51 HLA-DQB1 HLA-DRB1
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.5 HLA-A HLA-B HLA-C
17 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
18 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.48 HLA-DQB1 HLA-DRB1
19 antigen processing and presentation GO:0019882 9.43 CD8A HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
20 immune response GO:0006955 9.32 CD8A FAS HLA-A HLA-B HLA-C HLA-DQB1
21 apoptotic process GO:0006915 10 FAS IFNA2 IL17A IL2RA NLRP1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1

Sources for Vogt-Koyanagi-Harada Disease

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