MCID: VGT001
MIFTS: 60

Vogt-Koyanagi-Harada Disease malady

Rare diseases, Neuronal diseases, Eye diseases, Immune diseases categories
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Summaries for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Vogt-koyanagi-harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  melanin is the substance that gives skin, hair, and eyes their color.  melanin is also found in the retina, where it plays a role in normal vision.  individuals with vogt-koyanagi-harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  research suggests this condition is an autoimmune disease.  vogt-koyanagi-harada syndrome is more common in individuals with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. last updated: 3/14/2014

MalaCards: Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to vitiligo and hepatitis c, and has symptoms including absent/decreased/thin eyebrows, retinal detachment and glaucoma. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are Hematopoietic cell lineage and IL12 signaling mediated by STAT4. The compounds gold sodium thiomalate and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:8 A hypersensitivity reaction type ii disease that is caused by t helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 43NIH Rare Diseases, 40NCIt, 58SNOMED-CT, 27ICD9CM, 35MeSH, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Eye diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
vogt-koyanagi-harada disease:
Inheritance: Multigenic/multifactorial; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

vogt-koyanagi-harada disease 8 10 45 49
uveomeningoencephalitic syndrome 8 62
vogt-koyanagi-harada syndrome 43
uveomenigitic syndrome 49
vogt-koyanagi syndrome 8
harada's disease 8
vkh syndrome 43


External Ids:

Disease Ontology8 DOID:12297
NCIt40 C85218
ICD9CM27 364.24, 363.22
MeSH35 D014607
ICD10 via Orphanet26 H20.8, H30.8
SNOMED-CT via Orphanet59 193497004

Related Diseases for Vogt-Koyanagi-Harada Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to vogt-koyanagi-harada disease

Symptoms for Vogt-Koyanagi-Harada Disease

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49Orphanet
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Symptoms:

49 (show all 13)
  • absent/decreased/thin eyebrows
  • retinal detachment
  • glaucoma
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • premature greying of hair
  • absent/decreased lashes
  • irregular/patchy skin hypopigmentation
  • visual loss/blindness/amblyopia
  • short stature/dwarfism/nanism
  • sensorineural deafness/hearing loss
  • mild visual loss/impaired visual acuity
  • cataract/lens opacification
  • intellectual deficit/mental/psychomotor retardation/learning disability

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Vogt-Koyanagi-Harada Disease

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Genetic Tests for Vogt-Koyanagi-Harada Disease

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Anatomical Context for Vogt-Koyanagi-Harada Disease

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33MalaCards
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MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

33
Eye, Skin, Retina, T cells, Ovary, Spinal cord

Animal Models for Vogt-Koyanagi-Harada Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3FASLG, FAS, PTPN22, TYR
2MP:00053818.2PTPN22, FAS, FASLG, IL2RA
3MP:00053797.9TYR, PTPN22, FAS, FASLG
4MP:00107687.8IL2RA, FASLG, FAS, PTPN22, TYR
5MP:00053877.7TYR, PTPN22, FAS, FASLG, IL2RA

Publications for Vogt-Koyanagi-Harada Disease

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Sources:
52PubMed
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Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50)    (show all 263)
idTitleAuthorsYear
1
Vogt-koyanagi-harada disease in an adolescent boy. (23869531)
2014
2
Vogt-Koyanagi-Harada disease in First Nations and MActis of Northern Alberta. (23769774)
2013
3
Retinal pigment epithelium folds as a diagnostic finding of Vogt-Koyanagi-Harada disease. (23149670)
2013
4
Indocyanine green angiography-guided management of Vogt-Koyanagi-Harada disease: differentiation between choroidal scars and active lesions. (23277207)
2013
5
Vogt-Koyanagi-Harada disease masquerading as a lymphoproliferative process of the uvea. (23913248)
2013
6
Vogt-Koyanagi-Harada disease: a forgotten entity in the Canadian uveitis landscape? (23769771)
2013
7
Vogt-Koyanagi-Harada disease in Thailand. (23163754)
2012
8
Probable Vogt-Koyanagi-Harada disease with initial unilateral ocular manifestation in a hepatitis C carrier. (22588777)
2012
9
Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease. (22669715)
2012
10
Imaging in the diagnosis and management of Vogt-Koyanagi-Harada disease. (22954938)
2012
11
Resolution of subretinal fluid with systemic corticosteroid treatment in acute Vogt-Koyanagi-Harada disease. (22942161)
2012
12
Vogt-Koyanagi-Harada disease presenting as acute angle closure glaucoma at onset. (22452682)
2011
13
Intravitreal triamcinolone acetonide for rebound phenomenon after high-dose intravenous steroid treatment in Vogt-Koyanagi-Harada disease. (22125406)
2011
14
Intravitreal bevacizumab injection for persistent serous retinal detachment associated with Vogt-Koyanagi-Harada disease. (20689964)
2011
15
Effect of the duration of immunomodulatory therapy on the clinical features of recurrent episodes in Vogt--Koyanagi--Harada disease. (21251241)
2011
16
Spectral domain optical coherence tomography and autofluorescence in a case of acute posterior multifocal placoid pigment epitheliopathy mimicking Vogt-Koyanagi-Harada disease: case report and review of literature. (21034311)
2011
17
Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. (19151926)
2010
18
Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease. (19965835)
2010
19
Morphologic changes in the anterior segment in patients with initial-onset or recurrent Vogt-Koyanagi-Harada disease. (20662662)
2010
20
The prognostic value of angiography in Vogt-Koyanagi-Harada disease. (20933219)
2010
21
Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. (21052896)
2010
22
Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease. (20036008)
2010
23
Vogt-Koyanagi-Harada disease: diagnosis and treatments update. (20829689)
2010
24
Usefulness of anterior chamber depth measurement for efficacy assessment of steroid pulse therapy in patients with Vogt-Koyanagi-Harada disease. (21052900)
2010
25
Spectral-domain cirrus optical coherence tomography of choroidal striations seen in the acute stage of Vogt-Koyanagi-Harada disease. (18834577)
2009
26
Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin? (18174263)
2008
27
Elevated choroidal blood flow velocity during systemic corticosteroid therapy in Vogt-Koyanagi-Harada disease. (19016661)
2008
28
Thunderclap headache as initial manifestation of Vogt-Koyanagi-Harada disease. (17868357)
2008
29
Characteristics of Vogt-Koyanagi-Harada disease in a French cohort: ethnicity, systemic manifestations, and HLA genotype data. (18379934)
2008
30
Vitreous surgery for macular hole in patients with Vogt-Koyanagi-Harada disease. (19278482)
2008
31
Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease. (18191100)
2008
32
Vogt-Koyanagi-Harada disease: inquiry into the genesis of a disease name in the historical context of Switzerland and Japan. (17468832)
2007
33
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease. (17253112)
2007
34
The spectrum of Vogt-Koyanagi-Harada disease in Turkey: VKH in Turkey. (16957877)
2007
35
IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. (17335887)
2007
36
Vogt-koyanagi-harada disease with onset in elderly patients aged 68 to 89 years. (17295144)
2007
37
Pathology of Vogt-Koyanagi-Harada disease. (17435969)
2007
38
Vogt-Koyanagi-Harada disease in patients with chronic hepatitis C. (16310490)
2005
39
Early manifestation of vogt-koyanagi-harada disease as unilateral posterior scleritis. (12457922)
2002
40
Pathogenesis of Vogt-Koyanagi-Harada disease. (12189608)
2002
41
Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation. (12397437)
2002
42
Complications and prognostic factors in Vogt-Koyanagi-Harada disease. (11336934)
2001
43
Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. (11120868)
2000
44
HLA-DRB1*0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease. (9548078)
1998
45
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient. (9510558)
1998
46
Vogt Koyanagi Harada disease. (2098028)
1990
47
Choroidal neovascularization in long-standing case of Vogt-Koyanagi-Harada disease. (6190031)
1983
48
Vitiligo with an inflammatory erythema in Vogt-Koyanagi-Harada disease: demonstration of filamentous masses and amyloid deposits. (7119218)
1982
49
Two cases of Vogt-Koyanagi-Harada disease. (13691273)
1960
50
Vogt-Koyanagi-Harada disease; treatment with prednisone. (13410236)
1957

Variations for Vogt-Koyanagi-Harada Disease

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Expression for genes affiliated with Vogt-Koyanagi-Harada Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome, 54R&D Systems, 5Cell Signaling Technology
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Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, HLA-DRB1
29.5HLA-DRB1, IL2RA
3
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.5IL2RA, HLA-DRB1
4
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.4IL2RA, FASLG
5
Show member pathways
IL2 signaling events mediated by STAT538
9.4FASLG, IL2RA
6
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.4IL2RA, FASLG
7
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.0FASLG, FAS
8
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0FAS, FASLG
9
Show member pathways
TRAIL signaling pathway38
9.0FASLG, FAS
10
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0FAS, FASLG
119.0FASLG, FAS
129.0FASLG, FAS
13
Show member pathways
9.0FAS, FASLG
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.9IL2RA, FASLG, HLA-DRB1
15
Show member pathways
8.6IL2RA, FASLG, FAS
16
Show member pathways
8.6IL2RA, FASLG, FAS
17
Show member pathways
Immune response CD16 signaling in NK cells60
8.5KIR2DS3, FASLG, FAS
188.2PTPN22, FAS, FASLG, IL2RA
19
Show member pathways
8.1HLA-DRB1, FAS, FASLG, IL2RA
20
Show member pathways
7.5KIR2DS3, IL2RA, FASLG, FAS, HLA-DRB1

Compounds for genes affiliated with Vogt-Koyanagi-Harada Disease

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate459.9IL2RA, HLA-DRB1
2ranitidine45 29 24 1112.9IL2RA, TYR
3selenite459.8IL2RA, TYR
4c-d4t459.8IL2RA, FASLG
5polysulfone459.6FASLG, IL2RA
6chitosan459.6FAS, TYR
7(glc)4459.4FASLG, FAS
8atpo29 4510.4FASLG, FAS
9sodium arsenite459.4IL2RA, FASLG
10nitrate459.4IL2RA, FASLG
11teniposide45 1110.4FAS, FASLG
12okt3459.3IL2RA, FAS
13methotrexate51 45 1111.2HLA-DRB1, FASLG, IL2RA
14concanamycin a45 6110.1FASLG, FAS, TYR
15c2ceramide459.0TYR, FAS, FASLG
162-chlorodeoxyadenosine459.0IL2RA, FASLG, FAS
17resveratrol45 61 24 1112.0FASLG, FAS, TYR
18vitamin d459.0IL2RA, FAS, TYR
19ivig459.0FAS, FASLG, IL2RA
20ifn-alpha459.0IL2RA, FASLG, FAS
21anisomycin45 1110.0IL2RA, FASLG, FAS
22agar459.0FASLG, FAS, TYR
23ionomycin458.9IL2RA, FASLG, FAS
243-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide458.9FASLG, FAS
255fluorouracil458.9IL2RA, FASLG, FAS
26rantes458.9FAS, FASLG, IL2RA
27sb 20358045 619.9FASLG, FAS, TYR
28epinephrine45 24 1110.9FAS, FASLG, IL2RA
29etoposide45 51 61 1111.9IL2RA, FASLG, FAS
30n acetylcysteine458.9FAS, FASLG, IL2RA
31dutp458.7FASLG, FAS
32rapamycin458.7IL2RA, FASLG, FAS
33ly294002458.7TYR, FAS, FASLG
34ascorbic acid45 249.6TYR, FAS, FASLG, IL2RA
35indomethacin45 29 61 1111.6IL2RA, FASLG, FAS, TYR
36polysaccharide458.6TYR, FAS, FASLG, IL2RA
37paclitaxel45 51 1110.6IL2RA, FASLG, FAS, TYR
38doxorubicin45 51 1110.6IL2RA, FASLG, FAS, TYR
39paraffin458.6IL2RA, FASLG, FAS, TYR
40genistein45 29 61 3 24 1113.6TYR, FAS, FASLG, IL2RA
41cisplatin45 51 61 1111.6TYR, FAS, FASLG, IL2RA
42aspartate458.6TYR, FAS, FASLG, IL2RA
43h2o2458.6TYR, FAS, FASLG, IL2RA
44testosterone45 61 24 1111.5TYR, FAS, FASLG, IL2RA
45dexamethasone45 51 29 1111.5TYR, FAS, FASLG, IL2RA
46glutamate458.5TYR, HLA-DRB1, PTPN22, FASLG, IL2RA
47vegf458.5TYR, FAS, FASLG, IL2RA
48cysteine458.4TYR, FAS, FASLG, IL2RA
49arginine458.3TYR, HLA-DRB1, PTPN22, FAS, IL2RA
50tyrosine457.7TYR, HLA-DRB1, PTPN22, FAS, FASLG, IL2RA

GO Terms for genes affiliated with Vogt-Koyanagi-Harada Disease

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16Gene Ontology
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Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.1FASLG, PTPN22, TYR
2external side of plasma membraneGO:0098977.8IL2RA, FASLG, FAS, HLA-DRB1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:0024379.7IL2RA, HLA-DRB1
2negative regulation of T cell proliferationGO:0421309.6IL2RA, HLA-DRB1
3activation-induced cell death of T cellsGO:0069249.4IL2RA, FAS
4inflammatory cell apoptotic processGO:0069259.3FASLG, FAS
5necroptotic signaling pathwayGO:0975279.3FASLG, FAS
6regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.2FAS, FASLG
7extrinsic apoptotic signaling pathwayGO:0971919.1FAS, FASLG
8extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.1FAS, FASLG
9apoptotic signaling pathwayGO:0971909.0FASLG, FAS
10activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.9FAS, FASLG
11immune responseGO:0069558.9IL2RA, FASLG, HLA-DRB1
12apoptotic processGO:0069158.3IL2RA, FASLG, FAS

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase bindingGO:0199009.3FAS, PTPN22

Products for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources for Vogt-Koyanagi-Harada Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet