Vogt-koyanagi-harada Disease malady

NIH Rare Diseases: Vogt-Koyanagi-Harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  Melanin is the substance that gives skin, hair, and eyes their color.  Melanin is also found in the retina, where it plays a role in normal vision.  Individuals with Vogt-Koyanagi-Harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  Research suggests this condition is an autoimmune disease.  Vogt-Koyanagi-Harada syndrome is more common in individuals with darker skin pigmentation including Asian, Middle Eastern, Hispanic, and Native American populations.³⁰

MalaCards: Vogt-koyanagi-harada Disease, also known as uveomeningoencephalitic syndrome, is related to sympathetic ophthalmia and hepatitis. An important gene associated with Vogt-koyanagi-harada Disease is TYR (tyrosinase (oculocutaneous albinism IA)), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cell adhesion molecules (CAMs). The compounds agar and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include retina, skin and t cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Disease Ontology: An autoimmune disease that is caused by t helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.⁶

Aliases & Descriptions:

vogt-koyanagi-harada disease 6 8 32 uveomeningoencephalitic syndrome 6 43 vogt-koyanagi-harada disease (disorder) 6 vogt-koyanagi-harada syndrome 30

vogt-koyanagi syndrome 6 harada's disease 6 vkh syndrome 30

Diseases related to vogt-koyanagi-harada disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 387)

id	Related Disease	Score	Top Affiliating Genes
1	sympathetic ophthalmia	33.0	HLA-C, HLA-DRB1, TYRP1
2	hepatitis	31.7	FASLG, FAS, IFNA2, HLA-A, HLA-DRB1
3	type 1 diabetes mellitus	30.6	KIR3DL1, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, PTPN22
4	hepatitis c	30.3	FAS, IFNA2, IFNG, HLA-A, HLA-DRB1, SOCS1
5	behcet's disease	30.2	KIR2DL1, KIR3DL1, IL2RA, IFNA2, HLA-A, HLA-B
6	anterior uveitis	28.7	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
7	vitiligo	26.8	CD8A, ARMC9, IL17A, IL2RA, FASLG, FAS
8	diabetes mellitus	24.1	KIR2DS5, KIR3DS1, KIR3DL1, KIR2DS2, KIR2DL2, MIF
9	uveitis	23.9	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
10	hypergammaglobulinemia	13.6	IL2RA, FAS, HLA-DRB1
11	aids, delayed/rapid progression to	13.6	KIR3DS1, KIR3DL1
12	amelanotic melanoma	13.5	TYR, TYRP1, DCT
13	carney complex	13.5	TYR, TYRP1, DCT
14	t-cell large granular lymphocyte leukemia	13.5	KIR2DL1, KIR2DL3, IL2RA
15	autoimmune lymphoproliferative syndrome	13.4	IL2RA, FASLG, FAS, SPP1
16	htlv-1 associated myelopathy/tropical spastic paraparesis	13.4	IL2RA, FASLG, HLA-A
17	waardenburg's syndrome	13.4	KIR2DS4, TYR, TYRP1
18	large granular lymphocyte leukemia	13.3	KIR2DL1, KIR2DL3, IL2RA, FASLG, FAS
19	chediak-higashi syndrome	13.3	TYR, TYRP1, DCT
20	cystic echinococcosis	13.3	IL2RA, HLA-B, HLA-DRB1
21	oculocutaneous albinism	13.3	TYR, TYRP1, DCT
22	chronic venous leg ulcers	13.3	FASLG, FAS, HLA-B, HLA-DRB1
23	multiple sclerosis	13.3	HLA-DQB1, HLA-DRB1
24	posterior uveitis	13.2	IL2RA, FASLG, FAS, IFNG
25	tuberculoid leprosy	13.2	IL2RA, IFNG
26	tropical spastic paraparesis	13.2	IL2RA, FASLG, IFNG
27	tubulointerstitial nephritis and uveitis	13.2	HLA-DQB1, HLA-DRB1
28	psoriatic arthritis	13.2	HLA-C, HLA-DRB1, PTPN22
29	pneumoconiosis	13.2	FASLG, FAS, HLA-DQB1, HLA-DRB1
30	panniculitis	13.2	IL2RA, FAS, IFNG
31	listeriosis	13.1	KIR2DS4, CD8A, IFNG
32	ocular cicatricial pemphigoid	13.1	MIF, HLA-DQB1, HLA-DRB1
33	postherpetic neuralgia	13.1	HLA-A, HLA-B, HLA-DRB1
34	acute graft versus host disease	13.1	KIR3DL1, IL2RA, FASLG, IFNG
35	lymphoproliferative syndrome	13.1	KIR3DL1, IL2RA, FASLG, FAS, HLA-A
36	pars planitis	13.1	HLA-A, HLA-B, HLA-DRB1
37	celiac disease	13.0	MIF, HLA-DQB1, HLA-DRB1
38	juvenile rheumatoid arthritis	13.0	IL2RA, HLA-DQB1, HLA-DRB1
39	lymphoblastic lymphoma	13.0	CD8A, FASLG, FAS, ICAM1
40	focal epithelial hyperplasia	12.9	IFNA2, HLA-DRB1
41	intrahepatic cholestasis	12.9	IL2RA, HLA-DQB1, HLA-DRB1, SOCS3
42	whipple disease	12.9	HLA-B, HLA-DQB1, HLA-DRB1
43	adenomyosis	12.9	KIR2DL3, KIR3DL1, HLA-DRB1, SPP1
44	autoimmune hepatitis	12.9	FAS, HLA-A, HLA-DQB1, HLA-DRB1
45	silicosis	12.9	FASLG, FAS, HLA-DQB1, HLA-DRB1, SPP1
46	b-cell non-hodgkin lymphoma	12.9	IL2RA, FASLG, FAS, ICAM1
47	adult-onset still's disease	12.8	MIF, IL2RA, FASLG, FAS, ICAM1, HLA-DRB1
48	calcinosis	12.8	KIR3DL2, HLA-DQB1, HLA-DRB1, SPP1
49	aspergillosis	12.8	IL17A, IL2RA, IFNG, HLA-DRB1
50	cervical squamous cell carcinoma	12.8	FASLG, FAS, HLA-A, HLA-DQB1, HLA-DRB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to vogt-koyanagi-harada disease:

²²

MGI Mouse Phenotypes related to vogt-koyanagi-harada disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	SOCS2, PTPN22, UACA
2	renal/urinary system phenotype	MP:0005367	9.7	UACA, TYR, SOCS1, SOCS2
3	liver/biliary system phenotype	MP:0005370	9.3	SOCS3, PTPN22, IFNG, UACA
4	digestive/alimentary phenotype	MP:0005381	8.8	SOCS3, SOCS2, SOCS1, IFNG, IL17A
5	immune system phenotype	MP:0005387	8.5	UACA, TYR, PTPN22, HLA-DQB1, HLA-C, IFNG
6	tumorigenesis	MP:0002006	8.0	SOCS1, TYRP1, TYR, SPP1, ICAM1, IFNG
7	integument phenotype	MP:0010771	7.3	TYRP1, DCT, SOCS1, SOCS2, SOCS3, SOCS5
8	cellular phenotype	MP:0005384	6.5	SOCS1, TYR, SPP1, PTPN22, HLA-DQB1, HLA-C
9	hematopoietic system phenotype	MP:0005397	6.2	HLA-C, HLA-DOA, HLA-DQB1, PTPN22, SPP1, SOCS1

Articles related to vogt-koyanagi-harada disease:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Elevated serum osteopontin levels and genetic polymor phisms of osteopontin are associated with Vogt-Koyanagi-Harada disease. (21810982)	Chu M.... Kijlstra A.	2011	SPP1
2	Expression of suppressor of cytokine signaling in pe ripheral blood monocular cells of patients with Vogt-Koyanagi-Harada disease. (20137421)	Liu Y.X.... Zhou Z.C.	2009	SOCS2, SOCS3, SOCS1
3	Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi- Harada disease in Japanese patients. (19503742)	Horie Y.... Ohno S.	2009	PTPN22
4	Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin? (18174263)	Prignano F.... Lotti T.	2008	TYR
5	KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease. (18571006)	Levinson R.D.... Rajalingam R.	2008	KIR3DL1, HLA-A, HLA-C
6	Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia). (18421226)	Yamaki K.... Ohono S.	2008	TYRP1
7	Ocular infiltrating CD 4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens (19069378)	Sugita S.	2008	TYR
8	IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. (17335887)	Chi W.... Kijlstra A.	2007	IL17A
9	Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease. (18199975)	Horie Y.... Ohno S.	2007	IFNG
10	Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease. (17253112)	Sugita S.... Mochizuki M.	2007	TYR
11	Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. (17200659)	Horie Y.... Ohno S.	2006	TYR, TYRP1, DCT
12	Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease. (16481377)	Otani S.... Kawakami Y.	2006	ARMC9
13	Vogt-Koyanagi-Harada disease in patients with chronic hepatitis C. (16310490)	Touitou V.... Lehoang P.	2005	IFNA2
14	HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. (15603876)	Levinson R.D.... Holland G.N.	2004	HLA-DQB1, HLA-DRB1
15	High-dose corticosteroid administration induces increase of serum macrophage migration inhibitory factor in patients with Vogt-Koyanagi-Harada's disease. (11220683)	Kitaichi N.... Nishihira J.	2000	MIF
16	Soluble intercellular adhesion molecule-1 (ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with BehAset's disease and Vogt-Koyanagi-Harada's disease. (10342043)	Uchio E.... Ohno S.	1999	ICAM1, IL2RA
17	Strong association of HLA class II sequences in Mexicans with Vogt-Koyanagi-Harada's disease. (10527396)	Alaez C.... Gorodezky C.	1999	HLA-DRB1
18	Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient. (9510558)	Kobayashi H.... Katagiri M.	1998	TYR
19	Expression of Fas antigen on helper T lymphocytes in Vogt-Koyanagi-Harada disease. (9646088)	Ohta K.... Yoshimura N.	1998	FAS, CD8A
20	Influence of HLA-DRB1 gene variation on the clinical course of Vogt-Koyanagi-Harada disease. (7906684)	Islam S.M.... Masuda K.	1994	HLA-DRB1
21	Characterization of T-cell subsets, soluble interleukin-2 receptors and interleukin-6 in Vogt-Koyanagi-Harada disease. (1635294)	Kogiso M.... Mimura Y.	1992	IL2RA

Genes related to vogt-koyanagi-harada disease according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	TYR	tyrosinase (oculocutaneous albinism IA)	11.1	Publications
2	FAS	Fas (TNF receptor superfamily, member 6)	11.1	Publications
3	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.1	Publications
4	IL2RA	interleukin 2 receptor, alpha	11.1	Publications
5	FASLG	Fas ligand (TNF superfamily, member 6)	11.1
6	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	11.1	Publications
7	KIR3DP1	killer cell immunoglobulin-like receptor, three domains, pseudogene 1	11.1	Publications
8	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.1	Publications
9	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.1	Publications
10	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.1	Publications
11	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	11.1	Publications
12	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.1	Publications
13	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.1	Publications
14	TYRP1	tyrosinase-related protein 1	11.1	Publications
15	KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	11.1	Publications
16	KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	11.1	Publications
17	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.1	Publications
18	SOCS2	suppressor of cytokine signaling 2	11.1	Publications
19	HLA-DOA	major histocompatibility complex, class II, DO alpha	11.1
20	KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	11.1	Publications
21	KIR2DS4	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4	11.1	Publications
22	SOCS5	suppressor of cytokine signaling 5	11.1	Publications
23	CD8A	CD8a molecule	11.1	Publications
24	SOCS1	suppressor of cytokine signaling 1	11.1	Publications
25	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	11.1
26	SOCS3	suppressor of cytokine signaling 3	11.1	Publications
27	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.1	Publications
28	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.1	Publications
29	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.1	Publications
30	ARMC9	armadillo repeat containing 9	11.1	Publications
31	DCT	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)	11.1	Publications
32	KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	11.1	Publications
33	KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	11.1	Publications
34	IL17A	interleukin 17A	11.1	Publications
35	HLA-C	major histocompatibility complex, class I, C	11.1	Publications
36	SPP1	secreted phosphoprotein 1	11.1	Publications
37	HLA-A	major histocompatibility complex, class I, A	11.1	Publications
38	HLA-B	major histocompatibility complex, class I, B	11.1	Publications
39	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.1	Publications
40	ICAM1	intercellular adhesion molecule 1	11.1	Publications
41	IFNA2	interferon, alpha 2	11.1	Publications
42	IFNG	interferon, gamma	11.1	Publications

Pathways related to vogt-koyanagi-harada disease according to GeneDecks:

(show all 49)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.7	FASLG, IL2RA
2	Cell adhesion molecules (CAMs)20	10.5	HLA-DOA, CD8A
3	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	IL2RA, FASLG, FAS
4	Jak/Stat Pathway3	10.3	SOCS1, SOCS2, SOCS3
5	Lymphocyte Signaling3	10.2	SOCS1, FASLG, IL2RA, CD8A
6	IL-9 Pathway36	10.1	SOCS1, SOCS2, SOCS3, SOCS5
7	Tyrosine metabolism20	10.1	DCT, TYRP1, TYR, MIF
8	Growth Hormone Signaling36	10.1	SOCS5, SOCS3, SOCS2, SOCS1
9	Prolactin Signaling36	10.0	SOCS1, SOCS2, SOCS3, SOCS5
10	Immune response IL-12 signaling pathway10	9.9	IL2RA, IFNG, SOCS3
11	Immune response_IL-12 signaling pathway41	9.8	SOCS3, IFNG, IL2RA
12	Immune response IL-22 signaling pathway10	9.8	IL2RA, HLA-DOA, HLA-DQB1, HLA-DRB1, SOCS3
13	Immune response_IL-22 signaling pathway41	9.8	SOCS3, HLA-DRB1, HLA-DQB1, HLA-DOA, IL2RA
14	ICos-ICosL Pathway in T-Helper Cell36	9.8	HLA-DRB1, HLA-DQB1, HLA-DOA, IL2RA
15	Asthma20	9.7	HLA-DOA, HLA-DQB1, HLA-DRB1
16	CTLA4 Signaling36	9.7	PTPN22, HLA-DRB1, HLA-DQB1, HLA-DOA, CD8A
17	STAT3 Pathway36	9.6	IL2RA, SOCS1, SOCS2, SOCS3, SOCS5
18	Immune response Antigen presentation by MHC class II10	9.6	HLA-DRB1, HLA-DQB1, HLA-DOA
19	African trypanosomiasis20	9.5	ICAM1, IFNG, FAS, FASLG
20	THC Differentiation Pathway36	9.5	IL2RA, IFNG, HLA-DOA, HLA-DQB1, HLA-DRB1
21	Leishmaniasis20	9.4	IFNG, HLA-DOA, HLA-DQB1, HLA-DRB1
22	Staphylococcus aureus infection20	9.4	ICAM1, HLA-DOA, HLA-DQB1, HLA-DRB1
23	Immune response_Antigen presentation by MHC class II41	9.4	HLA-DOA, HLA-DQB1, HLA-DRB1
24	IL-4 Pathway36	9.4	SOCS5, SOCS3, SOCS2, SOCS1, HLA-DRB1, HLA-DQB1
25	Immune response Antigen presentation by MHC class I10	9.3	HLA-C, HLA-B, HLA-A, CD8A
26	Immune response_Antigen presentation by MHC class I41	9.3	HLA-C, HLA-B, HLA-A, CD8A
27	Toxoplasmosis20	9.3	SOCS1, HLA-DRB1, HLA-DQB1, HLA-DOA, IFNG
28	Immune response_MIF-mediated glucocorticoid regulation41	9.2	ICAM1, IFNG, MIF
29	Immune response Role of DAP12 receptors in NK cells10	9.2	KIR2DL1, KIR2DL4, KIR2DS2, KIR2DL5A, KIR2DS1, KIR2DL2
30	Immune response MIF-mediated glucocorticoid regulation10	9.2	ICAM1, IFNG, MIF
31	Immune response_Role of DAP12 receptors in NK cells41	9.2	KIR2DL1, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, HLA-B
32	Measles20	9.1	IFNG, IFNA2, FAS, FASLG, IL2RA
33	CTL Mediated Apoptosis36	8.9	HLA-DRB1, HLA-DQB1, HLA-DOA, HLA-C, HLA-B, HLA-A
34	Phagosome20	8.9	HLA-DRB1, HLA-DQB1, HLA-DOA, HLA-C, HLA-B, HLA-A
35	CDC42 Pathway36	8.8	HLA-DRB1, HLA-DQB1, HLA-DOA, HLA-C, HLA-B, HLA-A
36	Cytokine-cytokine receptor interaction20	8.8	IFNG, IFNA2, FAS, FASLG, IL2RA, IL17A
37	Jak-STAT signaling pathway20	8.7	SOCS5, SOCS3, SOCS2, SOCS1, IFNG, IFNA2
38	JAK-STAT Pathway36	8.6	SOCS5, SOCS3, SOCS2, SOCS1, IFNG, IFNA2
39	Rheumatoid arthritis20	8.6	HLA-DRB1, HLA-DQB1, HLA-DOA, ICAM1, IFNG, IL17A
40	Tuberculosis20	8.5	HLA-DRB1, HLA-DQB1, HLA-DOA, IFNG, IFNA2
41	Viral myocarditis20	8.3	HLA-DRB1, HLA-DQB1, HLA-DOA, HLA-C, HLA-B, HLA-A
42	Type I diabetes mellitus20	8.2	HLA-DQB1, HLA-DRB1, HLA-DOA, HLA-C, FASLG, FAS
43	Allograft rejection20	8.2	FASLG, FAS, IFNG, HLA-A, HLA-B, HLA-C
44	Graft-versus-host disease20	8.2	HLA-C, HLA-DOA, HLA-B, HLA-A, KIR3DL2, KIR2DL1
45	Autoimmune thyroid disease20	7.9	HLA-DRB1, HLA-DQB1, HLA-DOA, HLA-C, HLA-B, HLA-A
46	Influenza A20	7.7	SOCS3, HLA-DRB1, HLA-DQB1, HLA-DOA, ICAM1, IFNG
47	Antigen processing and presentation20	7.5	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
48	Immune System38	7.1	KIR2DS5, HLA-DOA, SOCS1, SOCS2, SOCS3, ICAM1
49	Natural killer cell mediated cytotoxicity20	5.6	ICAM1, HLA-A, HLA-B, HLA-C, IFNG, KIR2DL3

Compounds related to vogt-koyanagi-harada disease according to GeneDecks:

(show top 50)    (show all 66)

id	Compound	Score	Top Affiliating Genes
1	agar32	10.6	TYRP1
2	endotoxin32	10.5	MIF, FASLG
3	dhica32	10.4	DCT, TYRP1, TYR
4	arbutin32	10.4	DCT, TYRP1, TYR
5	dopaquinone32 18	11.4	TYR, TYRP1, DCT
6	eumelanin32	10.4	DCT, TYRP1, TYR
7	l-dopachrome32 18	11.3	DCT, TYR, MIF
8	5,6-dihydroxyindole32 18	11.3	MIF, TYR, DCT
9	dopachrome32	10.2	DCT, TYRP1, TYR, MIF
10	aspartate32	10.1	FASLG, HLA-DQB1, TYR
11	gp 13032	10.1	SOCS3, SOCS1, TYRP1, FAS, IL2RA
12	concanamycin a42 32	11.0	TYR, IFNG, FAS, FASLG
13	dr-1032	10.0	HLA-DRB1, HLA-A
14	okt332	10.0	ICAM1, FAS, IL2RA
15	gold sodium thiomalate32	10.0	HLA-DRB1, IFNG, IL2RA
16	pge232	9.9	SOCS3, SPP1, FASLG, IL17A
17	tuberculin32	9.9	IFNG, IL2RA, MIF
18	ivig32	9.9	IFNG, FAS, FASLG, IL2RA
19	sb 20358032 42	10.6	TYR, SPP1, IFNG, IL17A
20	vegf32	9.5	TYR, SPP1, ICAM1, MIF
21	natalizumab32 9 9	11.3	ICAM1, IFNG, IL2RA
22	paraffin32	9.3	TYR, SPP1, HLA-B, FAS, FASLG, IL2RA
23	levamisole32 9 9	11.2	SPP1, HLA-A, IFNA2, IL2RA
24	con a32	9.2	IL2RA, IFNA2, IFNG, SOCS3
25	ridostin32	9.1	IFNG, IFNA2
26	larifan32	9.0	IFNG, IFNA2
27	herbimycin a32 42	9.9	SPP1, ICAM1, IFNG, FAS, IL2RA, MIF
28	2,5-oligoadenylate32	8.9	HLA-B, IFNG, IFNA2, IL2RA
29	cysteine32	8.8	DCT, TYR, IFNG, IFNA2, FASLG, KIR2DS4
30	genistein32 9 18 9	11.7	TYR, SPP1, ICAM1, IFNG, FAS, FASLG
31	5fluorouracil32	8.7	HLA-A, IFNG, IFNA2, FAS, FASLG, IL2RA
32	5-aza-2deoxycytidine32	8.7	SOCS3, SOCS1, HLA-B, HLA-A, IFNG, FAS
33	infliximab32 9 9	10.7	SPP1, IFNG, IFNA2, FAS, IL2RA, IL17A
34	ascorbic acid32 18	9.6	TYR, SPP1, ICAM1, IFNA2, FAS, FASLG
35	cisplatin32 34 9 9	11.6	TYR, SPP1, IFNA2, FAS, FASLG, IL2RA
36	tacrolimus32 34 9 9	11.6	SPP1, HLA-B, HLA-A, IFNG, FASLG, IL2RA
37	h2o232	8.6	TYRP1, TYR, SPP1, HLA-B, ICAM1, FAS
38	actinomycin d32	8.5	SOCS1, SPP1, ICAM1, IFNG, FAS, FASLG
39	indomethacin32 9 9	10.5	TYR, SPP1, IFNG, IFNA2, FAS, FASLG
40	phosphatidylinositol32	8.5	SOCS3, SOCS2, SOCS1, SPP1, ICAM1, FAS
41	rantes32	8.5	HLA-B, ICAM1, IFNG, FAS, FASLG, IL2RA
42	ifn-alpha32	8.4	SOCS3, SOCS2, SOCS1, IFNG, IFNA2, FAS
43	arginine32	8.3	TYR, SPP1, PTPN22, HLA-DRB1, HLA-B, HLA-A
44	neopterin32	8.1	ICAM1, IFNG, IFNA2, IL2RA
45	dexamethasone32 42 34 9 9	12.0	TYR, SPP1, HLA-B, ICAM1, IFNG, FAS
46	cyclosporin a32 42	8.9	SPP1, HLA-B, HLA-A, ICAM1, IFNG, FAS
47	nitric oxide32 9 18 9	10.9	SOCS3, SOCS1, HLA-B, ICAM1, IFNG, FAS
48	oligonucleotide32	7.7	SOCS3, DCT, TYRP1, SPP1, HLA-DRB1, HLA-DQB1
49	retinoic acid32 42 18	8.9	SOCS1, DCT, TYR, SPP1, HLA-B, ICAM1
50	tyrosine32	4.2	KIR2DL1, HLA-B, HLA-DQB1, HLA-DRB1, PTPN22, SPP1

Cellular components related to vogt-koyanagi-harada disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	melanosome membrane	GO:033162	10.0	DCT, TYRP1, TYR
2	MHC class II protein complex	GO:042613	9.7	HLA-DOA, HLA-DQB1, HLA-DRB1
3	clathrin-coated endocytic vesicle membrane	GO:030669	9.4	HLA-DQB1, HLA-DRB1, TYRP1
4	phagocytic vesicle membrane	GO:030670	9.3	HLA-A, HLA-B, HLA-C
5	MHC class I protein complex	GO:042612	9.2	HLA-C, HLA-B, HLA-A
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.8	HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
7	ER to Golgi transport vesicle membrane	GO:012507	8.8	HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
8	external side of plasma membrane	GO:009897	8.7	HLA-DRB1, ICAM1, IFNG, FAS, FASLG, IL17A
9	integral to plasma membrane	GO:005887	6.8	KIR2DS3, HLA-DRB1, HLA-C, HLA-B, HLA-A, ICAM1
10	plasma membrane	GO:005886	5.8	IL2RA, FAS, ICAM1, HLA-A, HLA-B, HLA-C

Biological processes related to vogt-koyanagi-harada disease according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory cell apoptotic process	GO:006925	10.4	FASLG, FAS
2	melanin biosynthetic process from tyrosine	GO:006583	10.3	TYR, DCT
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.0	SOCS1, SOCS2, SOCS3
4	JAK-STAT cascade	GO:007259	9.8	SOCS1, SOCS2, SOCS3
5	regulation of interferon-gamma-mediated signaling pathway	GO:060334	9.7	SOCS3, SOCS1, IFNG
6	detection of bacterium	GO:016045	9.7	HLA-A, HLA-B, HLA-DRB1
7	positive regulation of interleukin-23 production	GO:032747	9.6	IL17A, IFNG
8	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	9.6	HLA-DQB1, HLA-DRB1
9	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	9.5	HLA-C, HLA-B, HLA-A
10	regulation of type I interferon-mediated signaling pathway	GO:060338	9.3	SOCS3, SOCS1, IFNA2
11	type I interferon-mediated signaling pathway	GO:060337	8.3	SOCS3, SOCS1, HLA-C, HLA-B, HLA-A, IFNA2
12	interferon-gamma-mediated signaling pathway	GO:060333	7.4	SOCS3, SOCS1, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B
13	regulation of immune response	GO:050776	7.2	HLA-C, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1
14	immune response	GO:006955	6.7	HLA-DRB1, HLA-DQB1, HLA-DOA, KIR2DS5, KIR2DL1, KIR2DL3
15	cytokine-mediated signaling pathway	GO:019221	6.3	SOCS5, SOCS3, SOCS1, HLA-DRB1, HLA-DQB1, HLA-C

Molecular functions related to vogt-koyanagi-harada disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	dopachrome isomerase activity	GO:004167	9.7	DCT, MIF
2	MHC class II receptor activity	GO:032395	9.6	HLA-DOA, HLA-DQB1, HLA-DRB1
3	transmembrane signaling receptor activity	GO:004888	9.5	KIR2DL4, KIR2DS2, KIR2DS1, ICAM1
4	MHC class I receptor activity	GO:032393	9.2	KIR3DS1, HLA-A, HLA-B, HLA-C
5	cytokine activity	GO:005125	8.1	SPP1, IFNG, IFNA2, FASLG, IL17A, MIF