MCID: VGT001
MIFTS: 60

Vogt-Koyanagi-Harada Disease

Categories: Rare diseases, Neuronal diseases, Eye diseases, Immune diseases

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 49 55 51 14
Uveomeningoencephalitic Syndrome 12 41 69
Vogt-Koyanagi-Harada Syndrome 49 36
Uveomenigitic Syndrome 49 55
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 49
Vkh Disease 49

Characteristics:

Orphanet epidemiological data:

55
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:12297
ICD10 32 H20.82 H30.81
ICD9CM 34 363.22 364.24
MeSH 41 D014607
NCIt 46 C85218
Orphanet 55 ORPHA3437
UMLS via Orphanet 70 C0042170
ICD10 via Orphanet 33 H20.8 H30.8
KEGG 36 H01504
UMLS 69 C0042170

Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : 49 Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis), white patches of skin (vitiligo), hair loss (alopecia), dizziness and nausea (inner ear related problems), and vision and hearing loss. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications. Last updated: 10/26/2017

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to uveitis and vitiligo-associated multiple autoimmune disease susceptibility 1, and has symptoms including abnormality of the eyelashes, glaucoma and visual impairment. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 uveitis 31.0 HLA-B IL10 IL17A IL2RA
2 vitiligo-associated multiple autoimmune disease susceptibility 1 30.6 NLRP1 PMEL PTPN22 TYR TYRP1
3 anterior uveitis 30.5 HLA-A HLA-B IL2RA PTPN22
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.4 IL10 IL17A PTPN22
5 graves' disease 30.3 FAS HLA-DRB1 IL2RA PTPN22
6 diabetes mellitus 30.0 HLA-DQB1 HLA-DRB1 IL2RA PTPN22
7 panuveitis 29.8 HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
8 autoimmune disease 28.2 FAS HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
9 alezzandrini syndrome 11.5
10 choroiditis 11.0
11 retinitis 10.8
12 hepatitis 10.6
13 hepatitis c 10.6
14 retinal detachment 10.6
15 headache 10.6
16 tyrosinase-like 10.5 TYR TYRP1
17 limbic encephalitis with lgi1 antibodies 10.5 HLA-DQB1 HLA-DRB1
18 sympathetic ophthalmia 10.5
19 melanoma 10.5
20 phenytoin or carbamazepine toxicity 10.5 HLA-A HLA-B
21 scleritis 10.5
22 metal allergy 10.5 HLA-DQB1 HLA-DRB1
23 focal epithelial hyperplasia 10.5 HLA-DQB1 HLA-DRB1
24 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
25 rheumatoid factor-negative juvenile idiopathic arthritis 10.4 HLA-DRB1 IL2RA PTPN22
26 beryllium disease 10.4 HLA-DQB1 HLA-DRB1
27 glaucomatocyclitic crisis 10.4 HLA-A HLA-B
28 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
29 fibrosis of extraocular muscles, congenital, 1 10.4
30 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
31 alopecia 10.4
32 leukemia 10.4
33 lymphoma 10.4
34 posterior scleritis 10.4
35 neuropathy 10.4
36 acute posterior multifocal placoid pigment epitheliopathy 10.4
37 central serous chorioretinopathy 10.4
38 recurrent respiratory papillomatosis 10.4 HLA-DQB1 HLA-DRB1
39 melanotic neurilemmoma 10.4 PMEL TYR
40 postherpetic neuralgia 10.4 HLA-A HLA-B HLA-DRB1
41 diffuse meningeal melanocytosis 10.4 PMEL TYR
42 chronic beryllium disease 10.4 HLA-DQB1 HLA-DRB1
43 halo nevi 10.4 HLA-DRB1 PMEL TYR
44 palindromic rheumatism 10.4 HLA-A HLA-DRB1 PTPN22
45 pars planitis 10.4 HLA-A HLA-B HLA-DRB1
46 juvenile myasthenia gravis 10.4 HLA-DRB1 IL10
47 nontuberculous mycobacterial lung disease 10.4 HLA-A HLA-B HLA-DRB1
48 melanoacanthoma 10.4 PMEL TYR
49 autoimmune pancreatitis 10.4 HLA-DQB1 HLA-DRB1
50 alveolar echinococcosis 10.3 HLA-A HLA-B HLA-DRB1

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease

Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

55 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the eyelashes 55 31 hallmark (90%) Very frequent (99-80%) HP:0000499
2 glaucoma 55 31 frequent (33%) Frequent (79-30%) HP:0000501
3 visual impairment 55 31 frequent (33%) Frequent (79-30%) HP:0000505
4 cataract 55 31 frequent (33%) Frequent (79-30%) HP:0000518
5 retinal detachment 55 31 frequent (33%) Frequent (79-30%) HP:0000541
6 sensorineural hearing impairment 55 31 hallmark (90%) Very frequent (99-80%) HP:0000407
7 vitiligo 55 31 hallmark (90%) Very frequent (99-80%) HP:0001045
8 hypopigmented skin patches 55 31 hallmark (90%) Very frequent (99-80%) HP:0001053
9 sparse scalp hair 55 31 hallmark (90%) Very frequent (99-80%) HP:0002209
10 premature graying of hair 55 31 hallmark (90%) Very frequent (99-80%) HP:0002216
11 poliosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0002290
12 short stature 55 31 frequent (33%) Frequent (79-30%) HP:0004322
13 cognitive impairment 55 31 hallmark (90%) Very frequent (99-80%) HP:0100543
14 abnormality of the eyebrow 55 Very frequent (99-80%)
15 abnormal eyebrow morphology 31 hallmark (90%) HP:0000534

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL17A IL2RA NLRP1 PMEL FAS HLA-DQB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 IL17A IL2RA NLRP1 PMEL FAS HLA-DQB1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 IL2RA HLA-DQB1 NLRP1 FAS IL10 IL17A
2 homeostasis/metabolism MP:0005376 10.18 IL17A GATA3 IL2RA HLA-DQB1 FAS IL10
3 endocrine/exocrine gland MP:0005379 10.11 IL17A GATA3 IL2RA HLA-DQB1 FAS IL10
4 immune system MP:0005387 10.11 GATA3 IL2RA HLA-DQB1 FAS IL10 IL17A
5 mortality/aging MP:0010768 10.06 IL17A GATA3 IL2RA HLA-DQB1 IL10 FAS
6 digestive/alimentary MP:0005381 10.02 IL17A GATA3 IL2RA HLA-DQB1 IL10 FAS
7 craniofacial MP:0005382 9.97 IL17A GATA3 IL10 FAS TYR TYRP1
8 reproductive system MP:0005389 9.76 GATA3 HLA-DQB1 IL10 FAS TYR TYRP1
9 pigmentation MP:0001186 9.65 GATA3 FAS TYR PMEL TYRP1
10 respiratory system MP:0005388 9.5 IL17A IL2RA HLA-DQB1 IL10 FAS PTPN22
11 vision/eye MP:0005391 9.17 GATA3 IL2RA IL10 FAS TYR PMEL

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 3
3 Angiogenesis Modulating Agents Phase 3
4
Azathioprine Approved 446-86-6 2265
5
Iodine Approved, Investigational 7553-56-2 807
6
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
7
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
8
Mycophenolic acid Approved 24280-93-1 446541
9
Povidone Approved 9003-39-8
10
Povidone-iodine Approved 25655-41-8
11 Anti-Bacterial Agents
12 Antibiotics, Antitubercular
13 Antifungal Agents
14 Anti-Infective Agents
15 Antirheumatic Agents
16 cadexomer iodine
17 Calcineurin Inhibitors
18 Cyclosporins
19 Dermatologic Agents
20 Immunosuppressive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study Unknown status NCT02015351 bevacizumab
3 Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease Recruiting NCT03399175 Early high-dose corticosteroid and immunosuppressive therapy

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

38
Eye, Skin, Retina, T Cells, Myeloid, Liver, Spinal Cord

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 392)
# Title Authors Year
1
Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection: A Case Report. ( 29321438 )
2018
2
Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )
2018
3
Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage. ( 29396390 )
2018
4
Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis. ( 29443768 )
2018
5
Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( 29111815 )
2018
6
Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. ( 29264653 )
2018
7
MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. ( 28972028 )
2018
8
Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease. ( 29334924 )
2018
9
Vogt-Koyanagi-Harada disease-like uveitis induced by vemurafenib for metastatic cutaneous malignant melanoma. ( 29314171 )
2018
10
Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study. ( 29339644 )
2018
11
Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease. ( 28868031 )
2017
12
Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )
2017
13
Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )
2017
14
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2017
15
Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient. ( 28574002 )
2017
16
Clinical spectrum and management options in Vogt-Koyanagi-Harada disease. ( 28848322 )
2017
17
Multispectral image analysis in Vogt-Koyanagi-Harada disease. ( 29220112 )
2017
18
Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. ( 28432342 )
2017
19
Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. ( 29138505 )
2017
20
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease. ( 28535268 )
2017
21
Unilateral Ocular Manifestations of Vogt-Koyanagi-Harada Disease. ( 29020488 )
2017
22
Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia. ( 28574001 )
2017
23
The effect on choroidal changes of the route of systemic corticosteroids in acute Vogt-Koyanagi-Harada disease. ( 28382438 )
2017
24
Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease. ( 28503445 )
2017
25
Promoter Hypermethylation of GATA3, IL-4, and TGF-I^ Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese. ( 28278322 )
2017
26
Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )
2017
27
Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt-Koyanagi-Harada disease. ( 29148525 )
2017
28
Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease. ( 29080887 )
2017
29
A case of Vogt Koyanagi Harada disease in a 16 year old girl. ( 29171577 )
2017
30
Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. ( 28299496 )
2017
31
Induction of Vogt-Koyanagi-Harada Disease by Interferon-Alpha and Ribavirin Treatment in Patients with Hepatitis C: A Case Report and Review of the Literature. ( 29023176 )
2017
32
Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )
2017
33
Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease. ( 29258782 )
2017
34
The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )
2017
35
Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography. ( 28700251 )
2017
36
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. ( 28761327 )
2017
37
Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging. ( 28091938 )
2017
38
Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease. ( 28695542 )
2017
39
F-18 FDG PET Findings for Vogt-Koyanagi-Harada Disease. ( 28559946 )
2017
40
Outcomes of Trabeculectomy With Mitomycin-C in Uveitis Associated With Vogt-Koyanagi-Harada Disease. ( 26900830 )
2016
41
Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population. ( 27046676 )
2016
42
Juvenile Vogt-Koyanagi-Harada Disease in Which Good Visual Prognosis Was Derived from Swift and Definitive Diagnosis. ( 27110416 )
2016
43
FLUOCINOLONE ACETONIDE IMPLANT FOR VOGT-KOYANAGI-HARADA DISEASE: Three-Year Outcomes of Efficacy and Safety. ( 27333235 )
2016
44
Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression. ( 27525196 )
2016
45
Vogt-Koyanagi-Harada disease. ( 27241814 )
2016
46
Successful Treatment of Vitiligo Associated with Vogt-Koyanagi-Harada Disease. ( 27981622 )
2016
47
Outcomes of Vogt-Koyanagi-Harada Disease: A Subanalysis From a Randomized Clinical Trial of Antimetabolite Therapies. ( 27296490 )
2016
48
Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity. ( 27003480 )
2016
49
KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease. ( 27490240 )
2016
50
The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease. ( 27048179 )
2016

Variations for Vogt-Koyanagi-Harada Disease

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 GATA3 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
13.17 GATA3 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10
3
Show member pathways
12.86 FAS HLA-A HLA-B IL2RA TLR3
4
Show member pathways
12.46 FAS HLA-A HLA-B TLR3
5
Show member pathways
12.4 HLA-A HLA-B HLA-DQB1 HLA-DRB1
6
Show member pathways
12.39 FAS HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL2RA
7
Show member pathways
12.3 FAS GATA3 IL10 IL17A
8
Show member pathways
12.3 FAS HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10
9
Show member pathways
12.27 GATA3 HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
10 12.21 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL2RA
11 12.03 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10
12 12.01 HLA-A HLA-B HLA-DQB1 HLA-DRB1
13
Show member pathways
11.99 HLA-A HLA-B IL10 IL17A
14 11.97 HLA-A HLA-B HLA-DQB1 HLA-DRB1
15 11.87 GATA3 IL10 IL17A
16
Show member pathways
11.86 HLA-A HLA-DRB1 IL2RA
17
Show member pathways
11.83 HLA-DQB1 HLA-DRB1 PTPN22
18 11.77 HLA-DQB1 HLA-DRB1 IL2RA
19
Show member pathways
11.75 GATA3 IL10 IL17A TLR3
20 11.74 FAS GATA3 IL10 IL17A IL2RA NLRP1
21
Show member pathways
11.73 IL17A TGFBR3 TLR3
22 11.72 HLA-DQB1 HLA-DRB1 IL17A
23 11.6 HLA-DQB1 HLA-DRB1 PTPN22
24 11.57 GATA3 IL10 IL17A IL2RA
25 11.48 HLA-DQB1 HLA-DRB1 IL10
26 11.38 GATA3 IL10 IL2RA
27
Show member pathways
11.23 FAS IL10 IL2RA
28 10.85 GATA3 TGFBR3
29 10.25 TYR TYRP1

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.85 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TLR3
2 external side of plasma membrane GO:0009897 9.71 HLA-DRB1 IL17A IL2RA TGFBR3
3 melanosome GO:0042470 9.65 PMEL TYR TYRP1
4 endosome membrane GO:0010008 9.62 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
5 cell surface GO:0009986 9.5 FAS HLA-A HLA-B HLA-DRB1 IL2RA TGFBR3
6 MHC class II protein complex GO:0042613 9.49 HLA-DQB1 HLA-DRB1
7 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-A HLA-B HLA-DQB1 HLA-DRB1
8 melanosome membrane GO:0033162 9.43 TYR TYRP1
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DQB1 HLA-DRB1 TYRP1
10 MHC class I protein complex GO:0042612 9.37 HLA-A HLA-B
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.92 HLA-A HLA-B HLA-DQB1 HLA-DRB1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 FAS IL10 IL17A IL2RA NLRP1 TLR3
2 T cell receptor signaling pathway GO:0050852 9.78 GATA3 HLA-DQB1 HLA-DRB1 PTPN22
3 negative regulation of inflammatory response GO:0050728 9.72 GATA3 IL10 IL2RA
4 negative regulation of T cell proliferation GO:0042130 9.63 HLA-DRB1 IL10 IL2RA
5 interferon-gamma-mediated signaling pathway GO:0060333 9.62 HLA-A HLA-B HLA-DQB1 HLA-DRB1
6 melanosome organization GO:0032438 9.58 PMEL TYRP1
7 positive regulation of T cell differentiation GO:0045582 9.58 GATA3 IL2RA
8 negative regulation of interferon-gamma production GO:0032689 9.58 GATA3 HLA-DRB1 IL10
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.57 HLA-DQB1 HLA-DRB1
10 inflammatory response to antigenic stimulus GO:0002437 9.56 HLA-DRB1 IL2RA
11 immune system process GO:0002376 9.56 GATA3 HLA-A HLA-B HLA-DRB1 IL2RA NLRP1
12 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-A HLA-B
13 necroptotic signaling pathway GO:0097527 9.52 FAS TLR3
14 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.51 HLA-DQB1 HLA-DRB1
15 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
16 antigen processing and presentation GO:0019882 9.46 HLA-A HLA-B HLA-DQB1 HLA-DRB1
17 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
18 melanin biosynthetic process GO:0042438 9.43 PMEL TYR TYRP1
19 immune response GO:0006955 9.28 FAS HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DQB1 HLA-DRB1

Sources for Vogt-Koyanagi-Harada Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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