MCID: VGT001
MIFTS: 56

Vogt-Koyanagi-Harada Disease malady

Neuronal diseases, Eye diseases categories

Summaries for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Vogt-koyanagi-harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  melanin is the substance that gives skin, hair, and eyes their color.  melanin is also found in the retina, where it plays a role in normal vision.  individuals with vogt-koyanagi-harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  research suggests this condition is an autoimmune disease.  vogt-koyanagi-harada syndrome is more common in individuals with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. last updated: 3/14/2014

MalaCards: Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to hepatitis and hepatitis c, and has symptoms including short stature/dwarfism/nanism, visual loss/blindness/amblyopia and retinal detachment. An important gene associated with Vogt-Koyanagi-Harada Disease is TYR (tyrosinase), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The compounds (glc)4 and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina.

Disease Ontology:8 An autoimmune disease that is caused by t helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Eye diseases


Characteristics (Orphanet epidemiological data):

48
vogt-koyanagi-harada disease:
Inheritance: Multigenic/multifactorial; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

vogt-koyanagi-harada disease 8 10 44 48
uveomeningoencephalitic syndrome 8 60
vogt-koyanagi-harada syndrome 42
vogt-koyanagi syndrome 8
uveomenigitic syndrome 48
harada's disease 8
vkh syndrome 42


External Ids:

Disease Ontology8 DOID:12297
MeSH34 D014607
ICD9CM27 364.24, 363.22
NCIt39 C85218
ICD10 via Orphanet26 H20.8, H30.8
SNOMED-CT via Orphanet57 193497004

Related Diseases for Vogt-Koyanagi-Harada Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to vogt-koyanagi-harada disease

Clinical Features for Vogt-Koyanagi-Harada Disease

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48Orphanet
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Symptoms:

48 (show all 13)
  • short stature/dwarfism/nanism
  • visual loss/blindness/amblyopia
  • retinal detachment
  • cataract/lens opacification
  • glaucoma
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • premature greying of hair
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • irregular/patchy skin hypopigmentation
  • sensorineural deafness/hearing loss
  • absent/decreased lashes
  • absent/decreased/thin eyebrows
  • mild visual loss/impaired visual acuity

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vogt-Koyanagi-Harada Disease

Drug clinical trials:

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Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

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Genetic Tests for Vogt-Koyanagi-Harada Disease

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Anatomical Context for Vogt-Koyanagi-Harada Disease

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32MalaCards
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MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

32
Eye, Skin, Retina, T cells, Ovary, Spinal cord

Animal Models for Vogt-Koyanagi-Harada Disease or affiliated genes

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Publications for Vogt-Koyanagi-Harada Disease

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50PubMed
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Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
TRAF5 and TRAF3IP2 Gene Polymorphisms Are Associated with BehAset's Disease and Vogt-Koyanagi-Harada Syndrome: A Case-Control Study. (24416204)
2014
2
The outcomes of indocyanine green angiography monitored immunotherapy in Vogt-Koyanagi-Harada disease. (23212203)
2013
3
Prognostic factors for clinical outcomes in patients with Vogt-Koyanagi-Harada disease treated with high-dose corticosteroids. (23575246)
2013
4
Development of acquired idiopathic generalized anhidrosis in a case of Vogt-Koyanagi-Harada disease. (24125704)
2013
5
Successful use of infliximab therapy in sight-threatening corticosteroid-resistant Vogt-Koyanagi-Harada disease. (23617262)
2013
6
A case of acute posterior multifocal placoid pigment epitheliopathy demonstrating vogt-koyanagi-harada disease-like optical coherence tomography findings in the acute stage. (24403900)
2013
7
Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease. (23359103)
2013
8
Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease. (22669715)
2012
9
Increased IL-7 expression in Vogt-Koyanagi-Harada disease. (22247488)
2012
10
Optic disc swelling in Vogt-Koyanagi-Harada disease. (22408010)
2012
11
Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. (23095726)
2012
12
The outcomes of mycophenolate mofetil therapy combined with systemic corticosteroids in acute uveitis associated with Vogt-Koyanagi-Harada disease. (22971163)
2012
13
Effect of the duration of immunomodulatory therapy on the clinical features of recurrent episodes in Vogt--Koyanagi--Harada disease. (21251241)
2011
14
Optical coherence tomographic assessment of dynamic macular changes in patients with Vogt-Koyanagi-Harada disease. (21194005)
2011
15
Headache in late pregnancy: a symptom for Vogt-Koyanagi-Harada disease. (21046128)
2011
16
Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. (21052896)
2010
17
Usefulness of anterior chamber depth measurement for efficacy assessment of steroid pulse therapy in patients with Vogt-Koyanagi-Harada disease. (21052900)
2010
18
Correlation between cerebrospinal fluid cell count and cerebrospinal fluid level of chemokine, monokine induced by interferon-gamma in Vogt-Koyanagi-Harada disease. (18700882)
2010
19
Retinal pigment epithelial changes in chronic Vogt-Koyanagi-Harada disease: fundus autofluorescence and spectral domain-optical coherence tomography findings. (20010321)
2010
20
Acute Vogt-Koyanagi-Harada disease in enhanced spectral-domain optical coherence tomography. (19643489)
2009
21
Delayed fellow eye involvement in patients with Vogt-Koyanagi-Harada disease. (19395635)
2009
22
Autofluorescence findings in Vogt-Koyanagi-Harada disease. (19882556)
2009
23
Acute lymphoblastic leukemia manifesting as acute Vogt-Koyanagi-Harada disease. (20046700)
2009
24
Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin? (18174263)
2008
25
Thunderclap headache as initial manifestation of Vogt-Koyanagi-Harada disease. (17868357)
2008
26
Posterior segment recurrences in Vogt-Koyanagi-Harada disease. (17898934)
2008
27
Longitudinal quantification of aqueous flare and cells in Vogt-Koyanagi-Harada disease. (17965105)
2008
28
Vogt-Koyanagi-Harada disease: inquiry into the genesis of a disease name in the historical context of Switzerland and Japan. (17468832)
2007
29
Vogt-koyanagi-harada disease with onset in elderly patients aged 68 to 89 years. (17295144)
2007
30
Vogt-Koyanagi-Harada disease after head trauma. (17932867)
2007
31
Role of intravitreal triamcinolone as an adjuvant in the management of Vogt-Koyanagi-Harada disease. (17951914)
2007
32
Work-up, diagnosis and management of acute Vogt-Koyanagi-Harada disease: a case of acute myopization with granulomatous uveitis. (17484019)
2007
33
Vogt-Koyanagi-Harada disease in Hispanic patients. (17380271)
2007
34
Pseudotumoral retinal pigment epithelium proliferation in a patient with Vogt-Koyanagi-Harada disease. (16966643)
2006
35
Vogt-Koyanagi-Harada disease. (16282153)
2005
36
Delayed regeneration of foveal cone photopigments in Vogt-Koyanagi-Harada disease at the convalescent stage. (14691190)
2004
37
A case of Vogt-Koyanagi-Harada disease with good visual acuity in spite of subfoveal fold. (14636850)
2003
38
Pathogenesis of Vogt-Koyanagi-Harada disease. (12189608)
2002
39
Complications and prognostic factors in Vogt-Koyanagi-Harada disease. (11336934)
2001
40
Subretinal fibrosis in patients with Vogt-Koyanagi-Harada disease. (10964836)
2000
41
Vogt-Koyanagi-Harada disease presenting initially as aseptic meningoencephalitis. (11136362)
2000
42
Analysis of 87 cases with Vogt-Koyanagi-Harada disease. (10913650)
2000
43
Vogt-Koyanagi-Harada disease. (11141638)
2000
44
Concurrent bilateral posterior scleritis and Vogt-Koyanagi-Harada disease in a patient with positive rheumatoid factor. (9286810)
1997
45
Dominance of activated T cells and interleukin-6 in aqueous humor in Vogt-Koyanagi-Harada disease. (8300361)
1994
46
A nationwide survey on the occurrence of Vogt-Koyanagi-Harada disease in Japan. (7967215)
1994
47
Class II major histocompatibility complex on melanocytes of Vogt-Koyanagi-Harada disease. (1929956)
1991
48
Vogt Koyanagi Harada disease. (2098028)
1990
49
HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. (2234843)
1990
50
CSF findings and distribution of T and B lymphocytes in Vogt-Koyanagi-Harada disease. (6336108)
1984

Genetic Variations for Vogt-Koyanagi-Harada Disease

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Expression for genes affiliated with Vogt-Koyanagi-Harada Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3FASLG, FAS
2
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10.3FASLG, FAS
3
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10.2IL2RA, FASLG, FAS
4
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10.1IL2RA, SOCS1, SOCS2
5
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10.1FAS, FASLG, HLA-DRB1, IL2RA
6
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10.1FAS, FASLG, HLA-DRB1, IL2RA
7
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10.1SOCS1, FASLG, HLA-DRB1, IL2RA
810.1SOCS1, FAS, FASLG, IL2RA
9
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10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
10
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10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
11
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10.0IL2RA, FASLG, FAS, SOCS1, SOCS2
12
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9.8KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
13
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9.6KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR3DS1, KIR2DL4
14
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9.3KIR2DS1, KIR2DL4, KIR3DL3, KIR2DS2, KIR2DL2, KIR2DS3
15
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9.2KIR2DS5, SOCS1, FAS, KIR2DS1, KIR2DL4, KIR2DS2

Compounds for genes affiliated with Vogt-Koyanagi-Harada Disease

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1(glc)44410.6FASLG, FAS
2concanamycin a44 5911.5FAS, FASLG, TYR
32-chlorodeoxyadenosine4410.5IL2RA, FASLG, FAS
4c-d4t4410.5FASLG, IL2RA
5ivig4410.5FAS, FASLG, IL2RA
6atpo44 2811.5FAS, FASLG
7c2ceramide4410.5TYR, FASLG, FAS
8resveratrol44 59 11 2413.4TYR
9ascorbic acid44 2411.4FAS, FASLG, TYR, IL2RA
10anisomycin44 1111.4IL2RA, FASLG, FAS
11indomethacin44 59 28 1113.4IL2RA, TYR, FASLG, FAS
12ifn-alpha4410.3IL2RA, FASLG, FAS, SOCS1, SOCS2
13polysaccharide4410.2FAS, FASLG, TYR, IL2RA
14gold sodium thiomalate4410.2IL2RA, HLA-DRB1
15paclitaxel44 49 1112.2IL2RA, TYR, FASLG, FAS
16gp 1304410.2SOCS1, FAS, IL2RA
17doxorubicin44 49 1111.8IL2RA, TYR, FASLG, FAS
18tyrosine449.8FASLG, FAS, SOCS1, SOCS2, HLA-DRB1, TYR

GO Terms for genes affiliated with Vogt-Koyanagi-Harada Disease

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16Gene Ontology
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Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1IL2RA, HLA-DRB1, FASLG, FAS
2integral to plasma membraneGO:0058879.3FASLG, HLA-DRB1, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1
3plasma membraneGO:0058869.0KIR2DS5, FAS, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:00243710.3IL2RA, HLA-DRB1
2inflammatory cell apoptotic processGO:00692510.3FASLG, FAS
3activation-induced cell death of T cellsGO:00692410.2FAS, IL2RA
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS
5regulation of immune responseGO:0507769.9KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
6immune responseGO:0069559.6KIR2DS5, FASLG, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.2SOCS1, SOCS2
2transmembrane signaling receptor activityGO:0048889.7KIR2DS1, KIR2DL4, KIR2DS2, FAS

Products for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources for Vogt-Koyanagi-Harada Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet