MCID: VGT001
MIFTS: 52

Vogt-Koyanagi-Harada Disease malady

Neuronal, Eye categories

Summaries for Vogt-Koyanagi-Harada Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Vogt-koyanagi-harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  melanin is the substance that gives skin, hair, and eyes their color.  melanin is also found in the retina, where it plays a role in normal vision.  individuals with vogt-koyanagi-harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  research suggests this condition is an autoimmune disease.  vogt-koyanagi-harada syndrome is more common in individuals with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. last updated: 11/1/2010

MalaCards: Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to hepatitis c and vitiligo, and has symptoms including intellectual deficit/mental/psychomotor retardation/learning disability, cataract/lens opacification and mild visual loss/impaired visual acuity. An important gene associated with Vogt-Koyanagi-Harada Disease is TYR (tyrosinase), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The compounds (glc)4 and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and spinal cord.

Disease Ontology:8 An autoimmune disease that is caused by t helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 43NIH Rare Diseases, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Eye


Characteristics (Orphanet epidemiological data):

49
vogt-koyanagi-harada disease:
Inheritance: Multigenic/multifactorial; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

vogt-koyanagi-harada disease 8 10 45 49
uveomeningoencephalitic syndrome 8 61
vogt-koyanagi-harada syndrome 43
vogt-koyanagi syndrome 8
uveomenigitic syndrome 49
harada's disease 8
vkh syndrome 43


External Ids:

Disease Ontology8 DOID:12297
MeSH35 D014607
ICD9CM27 364.24, 363.22
NCIt40 C85218
ICD10 via Orphanet26 H20.8, H30.8
SNOMED-CT via Orphanet58 193497004

Related Diseases for Vogt-Koyanagi-Harada Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to vogt-koyanagi-harada disease

Clinical Features for Vogt-Koyanagi-Harada Disease

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 13)
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • cataract/lens opacification
  • mild visual loss/impaired visual acuity
  • sensorineural deafness/hearing loss
  • short stature/dwarfism/nanism
  • visual loss/blindness/amblyopia
  • irregular/patchy skin hypopigmentation
  • absent/decreased lashes
  • premature greying of hair
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • glaucoma
  • retinal detachment
  • absent/decreased/thin eyebrows

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Vogt-Koyanagi-Harada Disease

Drug clinical trials:

Search ClinicalTrials for Vogt-Koyanagi-Harada Disease

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Search CenterWatch for Vogt-Koyanagi-Harada Disease

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

33
Skin, Ovary, Spinal cord, Retina, T cells, B lymphoblasts, B cells

Animal Models for Vogt-Koyanagi-Harada Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Vogt-Koyanagi-Harada Disease

Sources:
51PubMed
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Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50)    (show all 280)
idTitleAuthorsYear
1
TRAF5 and TRAF3IP2 Gene Polymorphisms Are Associated with BehAset's Disease and Vogt-Koyanagi-Harada Syndrome: A Case-Control Study. (24416204)
2014
2
The outcomes of indocyanine green angiography monitored immunotherapy in Vogt-Koyanagi-Harada disease. (23212203)
2013
3
Case of Vogt-Koyanagi-Harada disease with psoriasis vulgaris. (23488594)
2013
4
Development of acquired idiopathic generalized anhidrosis in a case of Vogt-Koyanagi-Harada disease. (24125704)
2013
5
Successful use of infliximab therapy in sight-threatening corticosteroid-resistant Vogt-Koyanagi-Harada disease. (23617262)
2013
6
Vogt-Koyanagi-Harada disease: presentation and implications in undocumented immigrants. (23707001)
2013
7
Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease. (22669715)
2012
8
Increased IL-7 expression in Vogt-Koyanagi-Harada disease. (22247488)
2012
9
Optic disc swelling in Vogt-Koyanagi-Harada disease. (22408010)
2012
10
Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. (23095726)
2012
11
Intravitreal triamcinolone acetonide for rebound phenomenon after high-dose intravenous steroid treatment in Vogt-Koyanagi-Harada disease. (22125406)
2011
12
Effect of the duration of immunomodulatory therapy on the clinical features of recurrent episodes in Vogt--Koyanagi--Harada disease. (21251241)
2011
13
Optical coherence tomographic assessment of dynamic macular changes in patients with Vogt-Koyanagi-Harada disease. (21194005)
2011
14
Headache in late pregnancy: a symptom for Vogt-Koyanagi-Harada disease. (21046128)
2011
15
Rituximab in refractory Vogt-Koyanagi-Harada disease. (21744181)
2011
16
Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with BehAset's disease in a Chinese Han population. (20620187)
2010
17
Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. (21052896)
2010
18
Usefulness of anterior chamber depth measurement for efficacy assessment of steroid pulse therapy in patients with Vogt-Koyanagi-Harada disease. (21052900)
2010
19
Correlation between cerebrospinal fluid cell count and cerebrospinal fluid level of chemokine, monokine induced by interferon-gamma in Vogt-Koyanagi-Harada disease. (18700882)
2010
20
Mutton fat-like subretinal precipitates associated with Vogt-Koyanagi-Harada disease. (20128649)
2010
21
Retinal pigment epithelial changes in chronic Vogt-Koyanagi-Harada disease: fundus autofluorescence and spectral domain-optical coherence tomography findings. (20010321)
2010
22
Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt-Koyanagi-Harada disease. (19910285)
2010
23
Spectral-domain cirrus optical coherence tomography of choroidal striations seen in the acute stage of Vogt-Koyanagi-Harada disease. (18834577)
2009
24
New insights into Vogt-Koyanagi-Harada disease. (19668980)
2009
25
Acute Vogt-Koyanagi-Harada disease in enhanced spectral-domain optical coherence tomography. (19643489)
2009
26
Effects of the duration of initial oral corticosteroid treatment on the recurrence of inflammation in Vogt-Koyanagi-Harada disease. (18369377)
2009
27
Delayed fellow eye involvement in patients with Vogt-Koyanagi-Harada disease. (19395635)
2009
28
Edema of the photoreceptor layer in Vogt-Koyanagi-Harada disease observed using high-resolution optical coherence tomography. (19568354)
2009
29
Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin? (18174263)
2008
30
Characteristics of Vogt-Koyanagi-Harada disease in a French cohort: ethnicity, systemic manifestations, and HLA genotype data. (18379934)
2008
31
Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease. (18191100)
2008
32
Longitudinal quantification of aqueous flare and cells in Vogt-Koyanagi-Harada disease. (17965105)
2008
33
Vogt-Koyanagi-Harada disease in children. (17479116)
2008
34
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease. (17253112)
2007
35
Vogt-Koyanagi-Harada disease after head trauma. (17932867)
2007
36
Spectrum of Vogt-Koyanagi-Harada disease in Singapore. (17103022)
2007
37
Work-up, diagnosis and management of acute Vogt-Koyanagi-Harada disease: a case of acute myopization with granulomatous uveitis. (17484019)
2007
38
Vogt-Koyanagi-Harada disease in Hispanic patients. (17380271)
2007
39
Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. (17200659)
2006
40
Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease. (15589059)
2005
41
Significant prognostic factors for Vogt-Koyanagi-Harada disease in the early stage. (15124893)
2004
42
Pathogenesis of Vogt-Koyanagi-Harada disease. (12189608)
2002
43
Subretinal fibrosis in patients with Vogt-Koyanagi-Harada disease. (10964836)
2000
44
Vogt-Koyanagi-Harada disease presenting initially as aseptic meningoencephalitis. (11136362)
2000
45
Dominance of activated T cells and interleukin-6 in aqueous humor in Vogt-Koyanagi-Harada disease. (8300361)
1994
46
Class II major histocompatibility complex on melanocytes of Vogt-Koyanagi-Harada disease. (1929956)
1991
47
Surface markers of peripheral blood lymphocytes in Vogt-Koyanagi-Harada disease. (3840207)
1985
48
CSF findings and distribution of T and B lymphocytes in Vogt-Koyanagi-Harada disease. (6336108)
1984
49
Sympathetic ophthalmia simulating vogt-Koyanagi-Harada's disease: a clinico-pathologic study of four cases. (6656012)
1983
50
Systemic corticosteroid treatment in Vogt-Koyanagi-Harada disease. (7056483)
1982

Genetic Variations for Vogt-Koyanagi-Harada Disease

Expression for genes affiliated with Vogt-Koyanagi-Harada Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for genes affiliated with Vogt-Koyanagi-Harada Disease

Sources:
54Reactome, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3FASLG, FAS
2
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10.3FASLG, FAS
3
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10.2IL2RA, FASLG, FAS
4
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10.1IL2RA, SOCS1, SOCS2
5
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10.1FAS, FASLG, HLA-DRB1, IL2RA
6
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10.1FAS, FASLG, HLA-DRB1, IL2RA
7
Hide members
10.1SOCS1, FASLG, HLA-DRB1, IL2RA
810.1SOCS1, FAS, FASLG, IL2RA
9
Hide members
10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
10
Hide members
10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
11
Hide members
10.0IL2RA, FASLG, FAS, SOCS1, SOCS2
12
Hide members
9.8KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
13
Hide members
9.6KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR3DS1, KIR2DL4
14
Hide members
9.3KIR2DS1, KIR2DL4, KIR3DL3, KIR2DS2, KIR2DL2, KIR2DS3
15
Hide members
9.2KIR2DS5, SOCS1, FAS, KIR2DS1, KIR2DL4, KIR2DS2

Compounds for genes affiliated with Vogt-Koyanagi-Harada Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1(glc)44510.6FASLG, FAS
2concanamycin a45 6011.5FAS, FASLG, TYR
32-chlorodeoxyadenosine4510.5IL2RA, FASLG, FAS
4c-d4t4510.5FASLG, IL2RA
5ivig4510.5FAS, FASLG, IL2RA
6atpo45 2911.5FAS, FASLG
7c2ceramide4510.5TYR, FASLG, FAS
8resveratrol45 60 11 2413.4TYR
9ascorbic acid45 2411.4FAS, FASLG, TYR, IL2RA
10anisomycin45 1111.4IL2RA, FASLG, FAS
11indomethacin45 60 29 1113.4IL2RA, TYR, FASLG, FAS
12ifn-alpha4510.3IL2RA, FASLG, FAS, SOCS1, SOCS2
13polysaccharide4510.2FAS, FASLG, TYR, IL2RA
14gold sodium thiomalate4510.2IL2RA, HLA-DRB1
15paclitaxel45 50 1112.2IL2RA, TYR, FASLG, FAS
16gp 1304510.2SOCS1, FAS, IL2RA
17doxorubicin45 50 1111.8IL2RA, TYR, FASLG, FAS
18tyrosine459.8FASLG, FAS, SOCS1, SOCS2, HLA-DRB1, TYR

GO Terms for genes affiliated with Vogt-Koyanagi-Harada Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1IL2RA, HLA-DRB1, FASLG, FAS
2integral to plasma membraneGO:0058879.3FASLG, HLA-DRB1, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1
3plasma membraneGO:0058869.0KIR2DS5, FAS, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:00243710.3IL2RA, HLA-DRB1
2inflammatory cell apoptotic processGO:00692510.3FASLG, FAS
3activation-induced cell death of T cellsGO:00692410.2FAS, IL2RA
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS
5regulation of immune responseGO:0507769.9KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
6immune responseGO:0069559.6KIR2DS5, FASLG, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.2SOCS1, SOCS2
2transmembrane signaling receptor activityGO:0048889.7KIR2DS1, KIR2DL4, KIR2DS2, FAS

Products for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources for Vogt-Koyanagi-Harada Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet