MCID: VGT001
MIFTS: 56

Vogt-Koyanagi-Harada Disease malady

Neuronal diseases, Eye diseases categories

Summaries for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Vogt-koyanagi-harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  melanin is the substance that gives skin, hair, and eyes their color.  melanin is also found in the retina, where it plays a role in normal vision.  individuals with vogt-koyanagi-harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  research suggests this condition is an autoimmune disease.  vogt-koyanagi-harada syndrome is more common in individuals with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. last updated: 3/14/2014

MalaCards: Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to hepatitis and hepatitis c, and has symptoms including short stature/dwarfism/nanism, visual loss/blindness/amblyopia and retinal detachment. An important gene associated with Vogt-Koyanagi-Harada Disease is TYR (tyrosinase), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The compounds (glc)4 and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina.

Disease Ontology:8 An autoimmune disease that is caused by t helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Eye diseases


Characteristics (Orphanet epidemiological data):

48
vogt-koyanagi-harada disease:
Inheritance: Multigenic/multifactorial; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

vogt-koyanagi-harada disease 8 10 44 48
uveomeningoencephalitic syndrome 8 60
vogt-koyanagi-harada syndrome 42
vogt-koyanagi syndrome 8
uveomenigitic syndrome 48
harada's disease 8
vkh syndrome 42


External Ids:

Disease Ontology8 DOID:12297
MeSH34 D014607
ICD9CM27 364.24, 363.22
NCIt39 C85218
ICD10 via Orphanet26 H20.8, H30.8
SNOMED-CT via Orphanet57 193497004

Related Diseases for Vogt-Koyanagi-Harada Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to vogt-koyanagi-harada disease

Clinical Features for Vogt-Koyanagi-Harada Disease

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48Orphanet
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Symptoms:

48 (show all 13)
  • short stature/dwarfism/nanism
  • visual loss/blindness/amblyopia
  • retinal detachment
  • cataract/lens opacification
  • glaucoma
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • premature greying of hair
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • irregular/patchy skin hypopigmentation
  • sensorineural deafness/hearing loss
  • absent/decreased lashes
  • absent/decreased/thin eyebrows
  • mild visual loss/impaired visual acuity

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vogt-Koyanagi-Harada Disease

Drug clinical trials:

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Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

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Genetic Tests for Vogt-Koyanagi-Harada Disease

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Anatomical Context for Vogt-Koyanagi-Harada Disease

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32MalaCards
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MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

32
Eye, Skin, Retina, T cells, Ovary, Spinal cord

Animal Models for Vogt-Koyanagi-Harada Disease or affiliated genes

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Publications for Vogt-Koyanagi-Harada Disease

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50PubMed
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Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Retinal pigment epithelium folds as a diagnostic finding of Vogt-Koyanagi-Harada disease. (23149670)
2013
2
Vogt-Koyanagi-Harada disease masquerading as a lymphoproliferative process of the uvea. (23913248)
2013
3
A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis. (23928854)
2013
4
Herpes zoster motor neuropathy in a patient with previous motor paresis secondary to Vogt-Koyanagi-Harada disease. (23221673)
2013
5
Vogt-Koyanagi-Harada disease: presentation and implications in undocumented immigrants. (23707001)
2013
6
Imaging in the diagnosis and management of Vogt-Koyanagi-Harada disease. (22954938)
2012
7
Chronic noninfectious uveitis associated with Vogt-Koyanagi-Harada disease treated with low-dose weekly systemic methotrexate. (22042569)
2012
8
Retinal functional changes measured by microperimetry after immunosuppressive therapy in patients with Vogt-Koyanagi-Harada disease. (21928252)
2012
9
Vogt-Koyanagi-Harada disease, diabetes mellitus, and psoriasis in a child. (22188226)
2012
10
Indocyanine green angiography findings in patients with long-standing Vogt-Koyanagi-Harada disease: a cross-sectional study. (22889440)
2012
11
Intravitreal bevacizumab injection for persistent serous retinal detachment associated with Vogt-Koyanagi-Harada disease. (20689964)
2011
12
A study of KIR genes and HLA-C in Vogt-Koyanagi-Harada disease in Saudi Arabia. (22219647)
2011
13
Linear immunoglobulin A/immunoglobulin G bullous dermatosis associated with Vogt-Koyanagi-Harada disease. (21545501)
2011
14
Vogt-Koyanagi-Harada disease occurring during pegylated interferon-I+2b and ribavirin combination therapy for chronic hepatitis C. (21494079)
2011
15
Inner retinal changes in acute-phase Vogt-Koyanagi-Harada disease measured by enhanced spectral domain optical coherence tomography. (21331684)
2011
16
Relapse of Vogt-Koyanagi-Harada Disease during Interferon-I+ and Ribavirin Therapy in a Case of Chronic Viral Hepatitis C. (21532994)
2011
17
Rituximab in refractory Vogt-Koyanagi-Harada disease. (21744181)
2011
18
The prognostic value of angiography in Vogt-Koyanagi-Harada disease. (20933219)
2010
19
Vogt-Koyanagi-Harada disease: diagnosis and treatments update. (20829689)
2010
20
Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt-Koyanagi-Harada disease. (19910285)
2010
21
Presumed Vogt-Koyanagi-Harada disease with unilateral ocular involvement: report of three cases. (19308440)
2009
22
Prognostic factors of Vogt-Koyanagi-Harada disease in Singapore. (18834575)
2009
23
Vogt-Koyanagi-Harada disease associated with brainstem encephalitis. (19201191)
2009
24
Choroidal folds in acute Vogt-Koyanagi-Harada disease. (19657984)
2009
25
Correlation between sunset glow fundus and initial dosage of corticosteroid in patients with Vogt-Koyanagi-Harada disease. (19376333)
2009
26
Type 1 diabetes mellitus associated with Graves' disease and Vogt-Koyanagi-Harada syndrome. (18591848)
2008
27
Headache as a first manifestation of Vogt-Koyanagi-Harada disease. (18408397)
2008
28
Vogt-Koyanagi-Harada disease in children. (17479116)
2008
29
Influence of early cerebrospinal fluid-guided diagnosis and early high-dose corticosteroid therapy on ocular outcomes of Vogt-Koyanagi-Harada disease. (17476572)
2007
30
Interferon-alpha2a and Vogt-Koyanagi-Harada disease: a double-edged sword? (17318324)
2007
31
Vogt-Koyanagi-Harada disease. (16770158)
2006
32
Choroidal dye filling velocity in patients with Vogt-Koyanagi-Harada disease. (16411096)
2006
33
Vogt-Koyanagi-Harada disease associated with interferon-A and ribavirin therapy for chronic hepatitis C infection. (15951019)
2006
34
Photodynamic therapy for subfoveal choroidal neovascularisation in Vogt-Koyanagi-Harada disease. (16687455)
2006
35
Evaluation of the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease. (16815259)
2006
36
Treatment of Vogt-Koyanagi-Harada disease by corticosteroids and immunosuppressive agents. (16597535)
2006
37
Decrease in the glyceraldehyde derived advanced glycation end products in the sera of patients with Vogt-Koyanagi-Harada disease. (16234440)
2005
38
Iris atrophy, serous detachment of the ciliary body, and ocular hypotony in chronic phase of Vogt-Koyanagi-Harada disease. (15812774)
2005
39
Ultrastructural changes in rat eyes with experimental Vogt-Koyanagi-Harada disease. (15175913)
2004
40
Annular choroidal detachment in a patient with Vogt-Koyanagi-Harada disease. (14963715)
2004
41
Significant prognostic factors for Vogt-Koyanagi-Harada disease in the early stage. (15124893)
2004
42
Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation. (12397437)
2002
43
Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease. (11336935)
2001
44
The contribution of indocyanine green angiography to the appraisal and management of Vogt-Koyanagi-Harada disease. (11150265)
2001
45
Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. (11336942)
2001
46
Histopathologic findings in the alopecia associated with Vogt-Koyanagi-Harada disease. (11003722)
2000
47
HLA-DR is strongly associated with Vogt-Koyanagi-Harada disease in Mexican Mestizo patients. (9689639)
1998
48
Expression of Fas antigen on helper T lymphocytes in Vogt-Koyanagi-Harada disease. (9646088)
1998
49
The uveo-encephalitic syndrome or Vogt-Koyanagi-Harada disease. (13573301)
1958
50
Vogt-Koyanagi-Harada disease; treatment with prednisone. (13410236)
1957

Genetic Variations for Vogt-Koyanagi-Harada Disease

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Expression for genes affiliated with Vogt-Koyanagi-Harada Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3FASLG, FAS
2
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10.3FASLG, FAS
3
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10.2IL2RA, FASLG, FAS
4
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10.1IL2RA, SOCS1, SOCS2
5
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10.1FAS, FASLG, HLA-DRB1, IL2RA
6
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10.1FAS, FASLG, HLA-DRB1, IL2RA
7
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10.1SOCS1, FASLG, HLA-DRB1, IL2RA
810.1SOCS1, FAS, FASLG, IL2RA
9
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10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
10
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10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
11
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10.0IL2RA, FASLG, FAS, SOCS1, SOCS2
12
Hide members
9.8KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
13
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9.6KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR3DS1, KIR2DL4
14
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9.3KIR2DS1, KIR2DL4, KIR3DL3, KIR2DS2, KIR2DL2, KIR2DS3
15
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9.2KIR2DS5, SOCS1, FAS, KIR2DS1, KIR2DL4, KIR2DS2

Compounds for genes affiliated with Vogt-Koyanagi-Harada Disease

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1(glc)44410.6FASLG, FAS
2concanamycin a44 5911.5FAS, FASLG, TYR
32-chlorodeoxyadenosine4410.5IL2RA, FASLG, FAS
4c-d4t4410.5FASLG, IL2RA
5ivig4410.5FAS, FASLG, IL2RA
6atpo44 2811.5FAS, FASLG
7c2ceramide4410.5TYR, FASLG, FAS
8resveratrol44 59 11 2413.4TYR
9ascorbic acid44 2411.4FAS, FASLG, TYR, IL2RA
10anisomycin44 1111.4IL2RA, FASLG, FAS
11indomethacin44 59 28 1113.4IL2RA, TYR, FASLG, FAS
12ifn-alpha4410.3IL2RA, FASLG, FAS, SOCS1, SOCS2
13polysaccharide4410.2FAS, FASLG, TYR, IL2RA
14gold sodium thiomalate4410.2IL2RA, HLA-DRB1
15paclitaxel44 49 1112.2IL2RA, TYR, FASLG, FAS
16gp 1304410.2SOCS1, FAS, IL2RA
17doxorubicin44 49 1111.8IL2RA, TYR, FASLG, FAS
18tyrosine449.8FASLG, FAS, SOCS1, SOCS2, HLA-DRB1, TYR

GO Terms for genes affiliated with Vogt-Koyanagi-Harada Disease

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16Gene Ontology
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Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1IL2RA, HLA-DRB1, FASLG, FAS
2integral to plasma membraneGO:0058879.3FASLG, HLA-DRB1, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1
3plasma membraneGO:0058869.0KIR2DS5, FAS, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:00243710.3IL2RA, HLA-DRB1
2inflammatory cell apoptotic processGO:00692510.3FASLG, FAS
3activation-induced cell death of T cellsGO:00692410.2FAS, IL2RA
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS
5regulation of immune responseGO:0507769.9KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
6immune responseGO:0069559.6KIR2DS5, FASLG, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.2SOCS1, SOCS2
2transmembrane signaling receptor activityGO:0048889.7KIR2DS1, KIR2DL4, KIR2DS2, FAS

Products for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources for Vogt-Koyanagi-Harada Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet