MCID: VGT001
MIFTS: 56

Vogt-Koyanagi-Harada Disease malady

Neuronal diseases, Eye diseases categories

Summaries for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Vogt-koyanagi-harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  melanin is the substance that gives skin, hair, and eyes their color.  melanin is also found in the retina, where it plays a role in normal vision.  individuals with vogt-koyanagi-harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  research suggests this condition is an autoimmune disease.  vogt-koyanagi-harada syndrome is more common in individuals with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. last updated: 3/14/2014

MalaCards: Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to hepatitis and hepatitis c, and has symptoms including absent/decreased/thin eyebrows, retinal detachment and glaucoma. An important gene associated with Vogt-Koyanagi-Harada Disease is TYR (tyrosinase), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The compounds (glc)4 and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina.

Disease Ontology:8 An autoimmune disease that is caused by t helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Eye diseases


Characteristics (Orphanet epidemiological data):

48
vogt-koyanagi-harada disease:
Inheritance: Multigenic/multifactorial; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

vogt-koyanagi-harada disease 8 10 44 48
uveomeningoencephalitic syndrome 8 60
vogt-koyanagi-harada syndrome 42
vogt-koyanagi syndrome 8
uveomenigitic syndrome 48
harada's disease 8
vkh syndrome 42


External Ids:

Disease Ontology8 DOID:12297
MeSH34 D014607
ICD9CM27 364.24, 363.22
NCIt39 C85218
ICD10 via Orphanet26 H20.8, H30.8
SNOMED-CT via Orphanet57 193497004

Related Diseases for Vogt-Koyanagi-Harada Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to vogt-koyanagi-harada disease

Clinical Features for Vogt-Koyanagi-Harada Disease

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48Orphanet
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Symptoms:

48 (show all 13)
  • absent/decreased/thin eyebrows
  • retinal detachment
  • glaucoma
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • premature greying of hair
  • absent/decreased lashes
  • irregular/patchy skin hypopigmentation
  • visual loss/blindness/amblyopia
  • short stature/dwarfism/nanism
  • sensorineural deafness/hearing loss
  • mild visual loss/impaired visual acuity
  • cataract/lens opacification
  • intellectual deficit/mental/psychomotor retardation/learning disability

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vogt-Koyanagi-Harada Disease

Drug clinical trials:

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Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Search CenterWatch for Vogt-Koyanagi-Harada Disease

Genetic Tests for Vogt-Koyanagi-Harada Disease

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Anatomical Context for Vogt-Koyanagi-Harada Disease

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32MalaCards
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MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

32
Eye, Skin, Retina, T cells, Spinal cord, Ovary

Animal Models for Vogt-Koyanagi-Harada Disease or affiliated genes

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Publications for Vogt-Koyanagi-Harada Disease

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50PubMed
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Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome. (23268366)
2014
2
Characteristics and prognosis of hearing loss associated with vogt-koyanagi-harada disease. (24335059)
2014
3
Indocyanine green angiography-guided management of Vogt-Koyanagi-Harada disease: differentiation between choroidal scars and active lesions. (23277207)
2013
4
Vogt-Koyanagi-Harada disease: a disorder unfamiliar to dermatologists. (23098571)
2013
5
CHOROIDAL THICKNESS IN CONVALESCENT VOGT-KOYANAGI-HARADA DISEASE. (23979311)
2013
6
Recurrent Vogt-Koyanagi-Harada disease with sensorineural hearing loss and choroidal thickening. (24022645)
2013
7
Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography. (22240936)
2012
8
Case report: Vogt-Koyanagi-Harada disease in an African-American female. (22859250)
2012
9
CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population. (22087016)
2012
10
Vogt-Koyanagi-Harada disease presenting as acute angle closure glaucoma at onset. (22452682)
2011
11
A case of vogt-koyanagi-harada disease associated with polycystic ovary syndrome. (21811536)
2011
12
Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease. (21331694)
2011
13
Indocyanine green angiography guided management of vogt-koyanagi-harada disease. (22454746)
2011
14
Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. (19151926)
2010
15
Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease. (19965835)
2010
16
Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease. (20036008)
2010
17
Longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease. (20547624)
2010
18
Vogt-Koyanagi-Harada disease occurring during interferon-alpha and ribavirin therapy for chronic hepatitis C virus infection. (20177954)
2010
19
Expression of suppressor of cytokine signaling in peripheral blood monocular cells of patients with Vogt-Koyanagi-Harada disease]. (20137421)
2009
20
Efficacy of infliximab therapy in two patients with refractory Vogt-Koyanagi-Harada disease. (19854741)
2009
21
Fluocinolone acetonide intravitreal implants in Vogt-Koyanagi-Harada disease. (20001265)
2009
22
A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease. (19568361)
2009
23
Revised diagnostic criteria for vogt-koyanagi-harada disease: considerations on the different disease categories. (18992868)
2009
24
HLA-DRB1 among patients with Vogt-Koyanagi-Harada disease in Saudi Arabia. (19756183)
2009
25
Applicability of the 2001 revised diagnostic criteria in Brazilian Vogt-Koyanagi-Harada disease patients. (18408841)
2008
26
Correlation between peripapillary atrophy and corticosteroid therapy in patients with Vogt-Koyanagi-Harada disease. (16980924)
2008
27
The spectrum of Vogt-Koyanagi-Harada disease in Turkey: VKH in Turkey. (16957877)
2007
28
Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease. (18199975)
2007
29
Tomographic features of serous retinal detachment with multilobular dye pooling in acute Vogt-Koyanagi-Harada disease. (17533104)
2007
30
The positive role of lumbar puncture in the diagnosis of Vogt-Koyanagi-Harada disease: lymphocyte subsets in the aqueous humor and cerebrospinal fluid. (17211585)
2007
31
Retinal fluorescein and indocyanine green angiography and optical coherence tomography in successive stages of Vogt-Koyanagi-Harada disease. (17273903)
2007
32
Association between severity of inflammation in CNS and development of sunset glow fundus in Vogt-Koyanagi-Harada disease. (16765691)
2006
33
Vogt-Koyanagi-Harada disease in Thai patients. (16681048)
2005
34
Experimentally induced Vogt-Koyanagi-Harada disease in two Akita dogs. (15670805)
2005
35
Optical coherence tomography in the acute and chronic phases of Vogt-Koyanagi-Harada disease. (16019683)
2005
36
Vogt-Koyanagi-Harada disease: clinical outcomes. (16226518)
2005
37
A case of vogt-koyanagi-harada disease associated with malignant lymphoma. (15944834)
2005
38
Bcl-2 expression by CD4 T lymphocytes in Vogt-Koyanagi-Harada disease. (12778345)
2002
39
Vogt-Koyanagi-Harada disease. (12434482)
2002
40
Ultrasound biomicroscopic study of ciliary body changes in the post-treatment phase of Vogt-Koyanagi-Harada disease. (12446369)
2002
41
Inflammatory vitiligo in Vogt-Koyanagi-Harada disease. (11148490)
2001
42
Disturbed expression of Fas/FasL on CD4(+) and CD8(+)T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome, and idiopathic anterior uveitis. (11815887)
2001
43
Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. (11120868)
2000
44
Multiple recurrences of exudative retinal detachment in a patient with Vogt-Koyanagi-Harada disease. (11131425)
2000
45
Quantitative evaluation of "sunset glow" fundus in Vogt-Koyanagi-Harada disease. (10482481)
1999
46
HLA-DRB1*0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease. (9548078)
1998
47
Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt-Koyanagi-Harada disease. (8671669)
1996
48
Vogt-Koyanagi-Harada disease during pregnancy. (7880803)
1995
49
Studies on corticosteroid therapy in Vogt-Koyanagi-Harada disease. (2089358)
1990
50
Two cases of Vogt-Koyanagi-Harada disease. (13691273)
1960

Genetic Variations for Vogt-Koyanagi-Harada Disease

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Expression for genes affiliated with Vogt-Koyanagi-Harada Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3FASLG, FAS
2
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10.3FASLG, FAS
3
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10.2IL2RA, FASLG, FAS
4
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10.1IL2RA, SOCS1, SOCS2
5
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10.1FAS, FASLG, HLA-DRB1, IL2RA
6
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10.1FAS, FASLG, HLA-DRB1, IL2RA
7
Hide members
10.1SOCS1, FASLG, HLA-DRB1, IL2RA
810.1SOCS1, FAS, FASLG, IL2RA
9
Hide members
10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
10
Hide members
10.0SOCS2, SOCS1, HLA-DRB1, IL2RA
11
Hide members
10.0IL2RA, FASLG, FAS, SOCS1, SOCS2
12
Hide members
9.8KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
13
Hide members
9.6KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR3DS1, KIR2DL4
14
Hide members
9.3KIR2DS1, KIR2DL4, KIR3DL3, KIR2DS2, KIR2DL2, KIR2DS3
15
Hide members
9.2KIR2DS5, SOCS1, FAS, KIR2DS1, KIR2DL4, KIR2DS2

Compounds for genes affiliated with Vogt-Koyanagi-Harada Disease

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1(glc)44410.6FASLG, FAS
2concanamycin a44 5911.5FAS, FASLG, TYR
32-chlorodeoxyadenosine4410.5IL2RA, FASLG, FAS
4c-d4t4410.5FASLG, IL2RA
5ivig4410.5FAS, FASLG, IL2RA
6atpo44 2811.5FAS, FASLG
7c2ceramide4410.5TYR, FASLG, FAS
8resveratrol44 59 11 2413.4TYR
9ascorbic acid44 2411.4FAS, FASLG, TYR, IL2RA
10anisomycin44 1111.4IL2RA, FASLG, FAS
11indomethacin44 59 28 1113.4IL2RA, TYR, FASLG, FAS
12ifn-alpha4410.3IL2RA, FASLG, FAS, SOCS1, SOCS2
13polysaccharide4410.2FAS, FASLG, TYR, IL2RA
14gold sodium thiomalate4410.2IL2RA, HLA-DRB1
15paclitaxel44 49 1112.2IL2RA, TYR, FASLG, FAS
16gp 1304410.2SOCS1, FAS, IL2RA
17doxorubicin44 49 1111.8IL2RA, TYR, FASLG, FAS
18tyrosine449.8FASLG, FAS, SOCS1, SOCS2, HLA-DRB1, TYR

GO Terms for genes affiliated with Vogt-Koyanagi-Harada Disease

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16Gene Ontology
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Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.1IL2RA, HLA-DRB1, FASLG, FAS
2integral to plasma membraneGO:0058879.3FASLG, HLA-DRB1, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1
3plasma membraneGO:0058869.0KIR2DS5, FAS, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:00243710.3IL2RA, HLA-DRB1
2inflammatory cell apoptotic processGO:00692510.3FASLG, FAS
3activation-induced cell death of T cellsGO:00692410.2FAS, IL2RA
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS
5regulation of immune responseGO:0507769.9KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL4, KIR2DS1
6immune responseGO:0069559.6KIR2DS5, FASLG, HLA-DRB1, IL2RA, KIR2DL3, KIR2DL1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.2SOCS1, SOCS2
2transmembrane signaling receptor activityGO:0048889.7KIR2DS1, KIR2DL4, KIR2DS2, FAS

Products for genes affiliated with Vogt-Koyanagi-Harada Disease

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Sources for Vogt-Koyanagi-Harada Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet