MCID: VGT001
MIFTS: 55

Vogt-Koyanagi-Harada Disease

Categories: Rare diseases, Neuronal diseases, Eye diseases, Immune diseases

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 50 56 52 14
Uveomeningoencephalitic Syndrome 12 42 69
Uveomenigitic Syndrome 50 56
Vogt-Koyanagi-Harada Syndrome 50
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 50
Vkh Disease 50

Characteristics:

Orphanet epidemiological data:

56
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : 50 vogt-koyanagi-harada disease (vkh disease) is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin. melanin is the substance that gives skin, hair, and eyes their color. melanin is also found in the retina, where it plays a role in normal vision. people with vkh disease usually develop vision and hearing disturbances first, followed by signs of skin problems. the most common symptoms include headaches, panuveitis, vitiligo, hair loss (alopecia), and inner ear disturbances. neurological symptoms may also occur. the exact cause of vkh disease is not well understood, but research suggests it is an autoimmune disease. it is more common in people with darker skin pigmentation including asian, middle eastern, hispanic, and native american populations. the disease is treated with corticosteroids and other medications. last updated: 9/2/2016

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to myelitis and alezzandrini syndrome, and has symptoms including short stature, visual impairment and sparse scalp hair. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Disease Ontology : 12 A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 myelitis 30.3 GATA3 HLA-B IL2RA
2 alezzandrini syndrome 11.4
3 choroiditis 10.9
4 retinitis 10.8
5 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 10.7 HLA-A HLA-B
6 fruit allergy 10.7 HLA-DQB1 HLA-DRB1
7 migraine with brainstem aura 10.7 HLA-B HLA-DRB1
8 breast hemangiopericytoma 10.7 HLA-DQB1 HLA-DRB1
9 cardioskeletal syndrome, kuwaiti type 10.6 HLA-A HLA-B
10 uveitis 10.6
11 biemond syndrome 10.6 HLA-DQB1 HLA-DRB1
12 light chain deposition disease 10.6 HLA-DQB1 HLA-DRB1
13 cerebral sarcoidosis 10.6 HLA-A HLA-DRB1 IL2RA
14 tropical spastic paraparesis 10.6 PMEL TYR
15 ramsay hunt syndrome i 10.6 HLA-A HLA-B HLA-DRB1
16 autoimmune retinopathy 10.5 HLA-DQB1 HLA-DRB1 IL2RA
17 hanhart syndrome 10.5 HLA-DRB1 PMEL TYR
18 childhood brainstem astrocytoma 10.5 PMEL TYR
19 hernia of ovary and fallopian tube 10.5 HLA-A HLA-B HLA-DRB1
20 mosaic trisomy 1 10.5 HLA-DQB1 HLA-DRB1
21 not otherwise specified 3-mga-uria type 10.5 HLA-A HLA-B HLA-DRB1
22 patau syndrome 10.5 HLA-A HLA-DRB1 PTPN22
23 hepatitis c 10.5
24 retinal detachment 10.5
25 hepatitis 10.5
26 aseptic meningitis 10.5 HLA-A HLA-B HLA-DRB1
27 portal vein thrombosis 10.5 PMEL TYR
28 acanthoma 10.5 HLA-A HLA-B HLA-DRB1
29 lens-induced iridocyclitis 10.5 HLA-A HLA-B HLA-C
30 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 10.5 IL17A IL2RA
31 respiratory system disease 10.5 HLA-B HLA-DRB1 IL2RA
32 acute cholangitis 10.5 HLA-B HLA-C HLA-DRB1
33 headache 10.5
34 kaposi sarcoma 10.5 HLA-DRB1 IL2RA PTPN22
35 idiopathic subglottic tracheal stenosis 10.5 HLA-B HLA-DQB1 HLA-DRB1
36 heterotaxy, visceral, 4, autosomal 10.5 HLA-A HLA-B HLA-C
37 intestinal disaccharidase deficiency 10.5 HLA-A IL2RA PTPN22
38 eye carcinoma in situ 10.5 HLA-A HLA-B HLA-DRB1
39 autism susceptibility 16 10.5 PMEL TYR TYRP1
40 emphysema, congenital lobar 10.4 HLA-A HLA-B HLA-DRB1
41 hemophagocytic lymphohistiocytosis 10.4 HLA-A HLA-B HLA-C
42 sympathetic ophthalmia 10.4
43 clear cell adenocarcinoma of ovary 10.4 HLA-DQB1 HLA-DRB1 IL17A
44 disease of mental health 10.4 HLA-B HLA-DRB1 IL17A
45 hemangioma-thrombocytopenia syndrome 10.4 HLA-A HLA-C IL17A
46 mesenchymal cell neoplasm 10.4 HLA-DRB1 IL17A PTPN22
47 reproductive system disease 10.4 HLA-DQB1 HLA-DRB1 IL17A
48 fallopian tube serous papilloma 10.4 PMEL TYR
49 clopidogrel resistance 10.4 HLA-DRB1 NLRP1 PTPN22
50 scleritis 10.4

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease

Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

56 32 (show all 14)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 short stature 56 32 frequent (33%) Frequent (79-30%) HP:0004322
2 visual impairment 56 32 frequent (33%) Frequent (79-30%) HP:0000505
3 sparse scalp hair 56 32 hallmark (90%) Very frequent (99-80%) HP:0002209
4 retinal detachment 56 32 frequent (33%) Frequent (79-30%) HP:0000541
5 cognitive impairment 56 32 hallmark (90%) Very frequent (99-80%) HP:0100543
6 glaucoma 56 32 frequent (33%) Frequent (79-30%) HP:0000501
7 cataract 56 32 frequent (33%) Frequent (79-30%) HP:0000518
8 sensorineural hearing impairment 56 32 hallmark (90%) Very frequent (99-80%) HP:0000407
9 premature graying of hair 56 32 hallmark (90%) Very frequent (99-80%) HP:0002216
10 hypopigmented skin patches 56 32 hallmark (90%) Very frequent (99-80%) HP:0001053
11 vitiligo 56 32 hallmark (90%) Very frequent (99-80%) HP:0001045
12 poliosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0002290
13 abnormality of the eyelashes 56 32 hallmark (90%) Very frequent (99-80%) HP:0000499
14 abnormality of the eyebrow 56 32 hallmark (90%) Very frequent (99-80%) HP:0000534

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.84 HLA-C HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.84 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.84 HLA-B HLA-C HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.84 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.84 HLA-C HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.84 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.84 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.84 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.84 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.84 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.84 HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.84 HLA-A HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.84 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.84 IFNA2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.84 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.84 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.84 HLA-A HLA-B HLA-C IFNA2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.84 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.84 HLA-A IL2RA HLA-B HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.84 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.84 IL2RA HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.84 IL2RA IFNA2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.84 IFNA2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.84 HLA-A HLA-B HLA-C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.84 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.84 HLA-C
27 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.84 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.84 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.84 IL2RA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.84 HLA-A HLA-B HLA-C
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.84 HLA-A HLA-B HLA-C
32 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.84 IL2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.84 HLA-C
34 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL17A IL2RA NLRP1 PMEL FAS HLA-DQB1
35 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 IL2RA NLRP1 PMEL FAS HLA-DQB1 IL17A

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 FAS GATA3 HLA-DQB1 IL17A IL2RA NLRP1
2 endocrine/exocrine gland MP:0005379 9.92 FAS GATA3 HLA-DQB1 IL17A IL2RA PTPN22
3 homeostasis/metabolism MP:0005376 9.9 FAS GATA3 HLA-DQB1 IL17A IL2RA NLRP1
4 immune system MP:0005387 9.65 HLA-DQB1 IL17A IL2RA NLRP1 PTPN22 TGFBR3
5 pigmentation MP:0001186 9.02 FAS GATA3 PMEL TYR TYRP1

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 3
3 Angiogenesis Modulating Agents Phase 3
4
Azathioprine Approved 446-86-6 2265
5
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
6
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
7
Mycophenolic acid Approved 24280-93-1 446541
8
Povidone Approved 9003-39-8
9 Povidone-iodine Approved 25655-41-8
10
Iodine Investigational 7553-56-2 807
11 Anti-Bacterial Agents
12 Antibiotics, Antitubercular
13 Antifungal Agents
14 Anti-Infective Agents
15 Antirheumatic Agents
16 cadexomer iodine
17 Calcineurin Inhibitors
18 Cyclosporins
19 Dermatologic Agents
20 Immunosuppressive Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study Unknown status NCT02015351 bevacizumab

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

39
Eye, Skin, Retina, T Cells, Liver, Spinal Cord, Myeloid

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 374)
id Title Authors Year
1
Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )
2017
2
Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )
2017
3
Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. ( 28299496 )
2017
4
Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease. ( 28503445 )
2017
5
The effect on choroidal changes of the route of systemic corticosteroids in acute Vogt-Koyanagi-Harada disease. ( 28382438 )
2017
6
Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )
2017
7
The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )
2017
8
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease. ( 28535268 )
2017
9
Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease. ( 28868031 )
2017
10
Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography. ( 28700251 )
2017
11
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. ( 28761327 )
2017
12
F-18 FDG PET Findings for Vogt-Koyanagi-Harada Disease. ( 28559946 )
2017
13
Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. ( 28432342 )
2017
14
Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging. ( 28091938 )
2017
15
Clinical spectrum and management options in Vogt-Koyanagi-Harada disease. ( 28848322 )
2017
16
Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia. ( 28574001 )
2017
17
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2017
18
Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )
2017
19
Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease. ( 28695542 )
2017
20
Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient. ( 28574002 )
2017
21
Promoter Hypermethylation of GATA3, IL-4, and TGF-I^ Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese. ( 28278322 )
2017
22
Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression. ( 27525196 )
2016
23
Adalimumab Treatment in Patients with Vogt-Koyanagi-Harada Disease. ( 27775450 )
2016
24
Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity. ( 27003480 )
2016
25
Outcomes of Trabeculectomy With Mitomycin-C in Uveitis Associated With Vogt-Koyanagi-Harada Disease. ( 26900830 )
2016
26
Fundus autofluorescence as a marker of disease severity in Vogt-Koyanagi-Harada disease. ( 27368955 )
2016
27
Incidence and Management of Glaucoma in Vogt Koyanagi Harada Disease. ( 26967258 )
2016
28
Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment. ( 26875727 )
2016
29
Point-of-Care Ultrasound Diagnosis of Bilateral Retinal Detachment Associated With Vogt-Koyanagi-Harada Disease in the Pediatric Emergency Department. ( 26890299 )
2016
30
Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population. ( 27046676 )
2016
31
Juvenile Vogt-Koyanagi-Harada Disease in Which Good Visual Prognosis Was Derived from Swift and Definitive Diagnosis. ( 27110416 )
2016
32
Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment. ( 26847039 )
2016
33
SUB-TENON TRIAMCINOLONE ACETONIDE INJECTION IN A PREGNANT PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE. ( 28033228 )
2016
34
Vogt-Koyanagi-Harada disease. ( 27241814 )
2016
35
FEATURES OF OPTICAL COHERENCE TOMOGRAPHY FOR THE DIAGNOSIS OF VOGT-KOYANAGI-HARADA DISEASE. ( 27145255 )
2016
36
Comment on: Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment. ( 27084081 )
2016
37
Changes of choroidal structure after corticosteroid treatment in eyes with Vogt-Koyanagi-Harada disease. ( 26906951 )
2016
38
Vogt-Koyanagi-Harada disease following BCG vaccination and tuberculosis. ( 27247899 )
2016
39
Topical difluprednate for treatment of serous retinal detachment and panuveitis associated with Vogt-Koyanagi-Harada disease. ( 27582676 )
2016
40
KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease. ( 27490240 )
2016
41
Successful Treatment of Vitiligo Associated with Vogt-Koyanagi-Harada Disease. ( 27981622 )
2016
42
Optical Intensities of Different Compartments of Subretinal Fluid in Acute Vogt-Koyanagi-Harada Disease. ( 26871896 )
2016
43
Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease. ( 26671509 )
2016
44
Outcomes of Vogt-Koyanagi-Harada Disease: A Subanalysis From a Randomized Clinical Trial of Antimetabolite Therapies. ( 27296490 )
2016
45
Surgical Treatment of Subretinal Fibrosis Caused Macular Detachment in Vogt-Koyanagi-Harada Disease: A Pioneer Study. ( 27494778 )
2016
46
Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. ( 27008848 )
2016
47
Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy. ( 27079805 )
2016
48
Detection of Asymptomatic Choroiditis by Fundus Examination in Vogt-Koyanagi-Harada Disease. ( 27379469 )
2016
49
FLUOCINOLONE ACETONIDE IMPLANT FOR VOGT-KOYANAGI-HARADA DISEASE: Three-Year Outcomes of Efficacy and Safety. ( 27333235 )
2016
50
A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt-Koyanagi-Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy. ( 27652046 )
2016

Variations for Vogt-Koyanagi-Harada Disease

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 GATA3 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
2
Show member pathways
13.22 GATA3 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
3 12.56 FAS HLA-A HLA-B HLA-C IFNA2 IL2RA
4
Show member pathways
12.48 GATA3 HLA-DQB1 HLA-DRB1 IL17A IL2RA
5
Show member pathways
12.41 FAS HLA-A HLA-B HLA-C IFNA2
6
Show member pathways
12.37 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 IFNA2
7
Show member pathways
12.35 FAS HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
8 12.29 HLA-A HLA-B HLA-C IL2RA
9 12.2 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
10 12.2 FAS GATA3 IL17A IL2RA NLRP1 PTPN22
11 12.14 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 IL2RA
12 12.01 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
13
Show member pathways
11.97 FAS HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
14 11.93 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15
Show member pathways
11.93 HLA-A HLA-B HLA-C IFNA2 IL17A
16
Show member pathways
11.86 HLA-A HLA-DRB1 IL2RA
17
Show member pathways
11.83 HLA-DQB1 HLA-DRB1 PTPN22
18
Show member pathways
11.82 GATA3 IL17A TLR3
19
Show member pathways
11.78 IL17A TGFBR3 TLR3
20 11.77 HLA-DQB1 HLA-DRB1 IL2RA
21 11.72 HLA-DQB1 HLA-DRB1 IL17A
22 11.66 GATA3 IL17A IL2RA
23 11.59 HLA-DQB1 HLA-DRB1 PTPN22
24 11.08 HLA-A HLA-B HLA-C
25 10.94 GATA3 TGFBR3
26 10.26 TYR TYRP1

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.85 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TLR3
2 endosome membrane GO:0010008 9.76 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
3 cell surface GO:0009986 9.76 FAS HLA-A HLA-B HLA-C HLA-DRB1 IL2RA
4 early endosome membrane GO:0031901 9.72 HLA-A HLA-B HLA-C
5 external side of plasma membrane GO:0009897 9.72 FAS HLA-DRB1 IL17A IL2RA TGFBR3
6 melanosome GO:0042470 9.69 PMEL TYR TYRP1
7 phagocytic vesicle membrane GO:0030670 9.65 HLA-A HLA-B HLA-C
8 recycling endosome membrane GO:0055038 9.61 HLA-A HLA-B HLA-C
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.58 HLA-DQB1 HLA-DRB1 TYRP1
10 MHC class II protein complex GO:0042613 9.54 HLA-DQB1 HLA-DRB1
11 melanosome membrane GO:0033162 9.49 TYR TYRP1
12 MHC class I protein complex GO:0042612 9.43 HLA-A HLA-B HLA-C
13 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15 integral component of membrane GO:0016021 10.3 FAS HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.96 HLA-A HLA-B HLA-C HLA-DRB1 NLRP1
2 inflammatory response GO:0006954 9.91 FAS IFNA2 IL17A IL2RA NLRP1 TLR3
3 T cell receptor signaling pathway GO:0050852 9.8 GATA3 HLA-DQB1 HLA-DRB1 PTPN22
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.74 HLA-A HLA-B HLA-C
5 type I interferon signaling pathway GO:0060337 9.71 HLA-A HLA-B HLA-C IFNA2
6 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.63 HLA-A HLA-B HLA-C
8 immune response GO:0006955 9.61 FAS HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
9 melanosome organization GO:0032438 9.6 PMEL TYRP1
10 positive regulation of T cell differentiation GO:0045582 9.59 GATA3 IL2RA
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.58 HLA-DQB1 HLA-DRB1
12 inflammatory response to antigenic stimulus GO:0002437 9.58 HLA-DRB1 IL2RA
13 necroptotic signaling pathway GO:0097527 9.55 FAS TLR3
14 antigen processing and presentation GO:0019882 9.55 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.54 HLA-DQB1 HLA-DRB1
16 melanin biosynthetic process GO:0042438 9.54 PMEL TYR TYRP1
17 activation-induced cell death of T cells GO:0006924 9.52 FAS IL2RA
18 protection from natural killer cell mediated cytotoxicity GO:0042270 9.51 HLA-A HLA-B
19 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.5 HLA-A HLA-B HLA-C
20 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.48 HLA-DQB1 HLA-DRB1
21 immune system process GO:0002376 9.28 GATA3 HLA-A HLA-B HLA-C HLA-DRB1 IL2RA
22 apoptotic process GO:0006915 10 FAS IFNA2 IL17A IL2RA NLRP1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
3 protein binding GO:0005515 10 FAS GATA3 HLA-A HLA-B HLA-C IFNA2

Sources for Vogt-Koyanagi-Harada Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....