Von Willebrand's Disease malady

Genetics Home Reference: Von Willebrand disease is a bleeding disorder that slows the blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience easy bruising, long-lasting nosebleeds, and excessive bleeding or oozing following an injury, surgery, or dental work. Mild forms of von Willebrand disease may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Women with this condition typically have heavy or prolonged bleeding during menstruation (menorrhagia), and some may also experience reproductive tract bleeding during pregnancy and childbirth. In severe cases of von Willebrand disease, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Symptoms of von Willebrand disease may change over time. Increased age, pregnancy, exercise, and stress may cause bleeding symptoms to become less frequent.¹⁷

MalaCards: Von Willebrand's Disease, also known as von willebrand disease, is related to type 3 von willebrand disease and pseudo-von willebrand disease. An important gene associated with Von Willebrand's Disease is VWF (von Willebrand factor), and among its related pathways are Warfarin Pathway, Pharmacodynamics and Response to elevated platelet cytosolic Ca2+. The drugs antihemophilic factor and antihemophilic factor,recombinant and the compounds abciximab and lysine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and heart, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Disease Ontology: A coagulation protein disease that is a hereditary abnormality which slows the blood clotting process. it arises from a qualitative or quantitative deficiency of von willebrand factor (vwf), a multimeric protein that is required for platelet adhesion.⁶

Wikipedia: Von Willebrand disease (vWD) is the most common hereditary coagulation abnormality described in humans,...⁴⁴ more...

GeneReviews summary for von-willebrand

Aliases & Descriptions:

von willebrand's disease 6 von willebrand disease 7 15 16 17 32 43 von willebrand factor deficiency 15 16 vascular pseudohemophilia 6 17 von willebrand's-jurgens' disease 6 von willebrand-jrgens disease 6

von willebrand disorder 6 von willebrands disease 8 vascular hemophilia 6 angiohemophilia 17 vwd 16

Diseases related to von willebrand's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 366)

id	Related Disease	Score	Top Affiliating Genes
1	type 3 von willebrand disease	36.1	VWF, F8, PLAT
2	pseudo-von willebrand disease	36.0	VWF, GP1BA
3	thrombosis	32.5	MTHFR, F8, F5, F2
4	type 1 von willebrand disease	31.2	VWF, MTHFR, P2RY12, F8, ADAMTS13
5	hereditary hemorrhagic telangiectasia	31.0	VWF, F5, F3
6	hemophilia	31.0	VWF, SELP, SERPINC1, MTHFR, IFNA1, F9
7	glanzmann's thrombasthenia	30.8	VWF, ITGA2, ITGA2B, ITGB3, GP1BA, F9
8	factor xi deficiency	30.6	VWF, F9, F8, F7, F5, F3
9	antithrombin iii deficiency	30.5	SERPINC1, MTHFR, F5, F2
10	acquired von willebrand syndrome	30.4	VWF, F8, F3, F2, F11
11	thrombasthenia	29.9	VWF, MTHFR, ITGA2, ITGA2B, ITGB3, GP9
12	factor viii deficiency	29.8	VWF, F9, F8, F7, F5, F3
13	hypofibrinogenemia	29.7	VWF, SERPINC1, F3, F2, PLAT
14	venous thrombosis	29.6	LRP1, VWF, SELP, SERPINC1, MTHFR, F9
15	bernard-soulier syndrome	29.4	VWF, ITGA2, ITGA2B, ITGB3, GP9, GP1BA
16	blood platelet disease	29.3	VWF, SELP, SERPINC1, F8, F3, PF4
17	hemophilia b	29.1	VWF, F9, F8, F7, F3, F2
18	systemic lupus erythematosus	29.0	VWF, IFNA1, F8, F3, F2, CALR
19	periodontitis	28.6	VWF, SELP, MTHFR, ITGA2, ITGB1, MMRN1
20	pulmonary embolism	28.4	PIK3C2A, SERPINC1, MTHFR, GP1BA, F9, F5
21	twinning	28.1	LRP1, VWF, SERPINC1, MTHFR, CFB, ITGA2
22	hypothyroidism	27.1	PIK3C2A, LRPAP1, VWF, SELP, SERPINC1, IFNA1
23	deep vein thrombosis	26.3	VWF, SELP, SERPINC1, MTHFR, ITGB3, F9
24	thrombocytopenia	25.8	PIK3C2A, VWF, SELP, SERPINC1, MTHFR, CFB
25	hepatitis c	25.1	SELP, SERPINC1, MTHFR, ITGA2, ITGA2B, ITGB1
26	lupus erythematosus	23.6	PIK3C2A, VWF, SELP, SERPINC1, MTHFR, P2RY12
27	atherosclerosis	21.5	PIK3C2A, LRP1, LRPAP1, VWF, SELP, SERPINC1
28	hepatitis	20.0	PIK3C2A, LRP1, VWF, SELP, SERPINC1, MTHFR
29	afibrinogenemia	13.7	VWF, F3, F2
30	stroke, ischemic	13.6	F5, F2
31	factor xii deficiency	13.6	F5, F3, F2
32	blood protein disease	13.6	MTHFR, F5, F2
33	vitamin k-dependent clotting factors	13.6	F9, F5, F2
34	bombay phenotype	13.6	VWF, ADAMTS13
35	porencephaly	13.6	MTHFR, F5, F2
36	vitamin k deficiency hemorrhagic disease	13.6	F9, F7, F3, F2
37	bilirubin metabolic disorder	13.5	F9, F2, ADAMTS13
38	hemarthrosis	13.5	VWF, F9, F8, F3, F2
39	vascular malformations	13.5	VWF, F3, F2
40	acquired hemophilia	13.5	F9, F8, F5, F3, F11
41	critical limb ischemia	13.5	VWF, F5, PLAT
42	gastroschisis	13.5	MTHFR, F5, F2
43	achenbach syndrome	13.5	F9, F8, F3, F2, PLAT
44	catastrophic antiphospholipid syndrome	13.5	MTHFR, F8, F5, F3, ADAMTS13
45	chronic myeloproliferative disease	13.5	MTHFR, F7, F5, F2
46	head injury	13.4	SELP, CD63, F3, F2
47	factor x deficiency	13.4	F9, F7, F5, F3, F2
48	factor v and factor viii	13.4	F8, F5, HSPA5
49	gray platelet syndrome	13.4	SELP, GP9, GP6
50	arterial occlusive disease	13.4	VWF, SELP, MTHFR, F3, PLAT

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 antihemophilic factor, antihemophilic factor,human, antihemophilic factor,human,method m,monoclonal, antihemophilic factor,porcine, antihemophilic factor,recombinant

Genetic tests related to von willebrand's disease:

id	Genetic test	Affiliating Genes
1	Von Willebrand's Disease clinical/research	VWF

MalaCards organs/tissues related to von willebrand's disease:

²²

MGI Mouse Phenotypes related to von willebrand's disease:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.9	ADAMTS13, F11, GP1BA, ITGA2B, ITGA2, P2RY12
2	liver/biliary system phenotype	MP:0005370	9.7	SERPINC1, F9, F11
3	reproductive system phenotype	MP:0005389	9.2	HSPA5, F8, ITGB1, ITGA2B, LRPAP1
4	embryogenesis phenotype	MP:0005380	8.7	PDIA3, CALR, HSP90B1, HSPA5, F2, SERPINC1
5	renal/urinary system phenotype	MP:0005367	8.7	CPB2, HSPA5, ITGB1, CD63, CFB, SELP
6	immune system phenotype	MP:0005387	8.5	F11, HSP90B1, PLAT, PDIA3, CPB2, ADAMTS13
7	skeleton phenotype	MP:0005390	7.6	COL11A2, PLAU, PLAT, ITGB3, ITGB1, CFB
8	normal phenotype	MP:0002873	7.3	ADAMTS13, HSPA5, F2, F3, F7, ITGB3
9	growth/size phenotype	MP:0005378	6.5	HSP90B1, CALR, PLAT, PLAU, COL11A2, PDIA3
10	cardiovascular system phenotype	MP:0005385	6.1	F3, F2, F11, HSPA5, HSP90B1, CALR
11	mortality/aging	MP:0010768	4.8	F3, F2, F11, HSPA5, HSP90B1, CALR
12	homeostasis/metabolism phenotype	MP:0005376	3.9	PIK3C2A, F8, F7, F5, F3, F2

Articles related to von willebrand's disease:

(show top 50)    (show all 440)

id	Title	Authors	Year	Affiliating Genes
1	Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand disease. (21596755)	Wang J.W.... Eikenboom J.	2011	VWF
2	Autosomal recessive von Willebrand disease type 1 or 2 due to homozygous or compound heterozygous mutations in the von Willebrand fa ctor gene. A single center experience on molecular heterogeneity and laboratory features in 12 families. (19506356)	Castaman G.... Rodeghiero F.	2009	VWF
3	Rapid molecular diagnosis of von Willebrand disease b y direct sequencing. Detection of 12 novel putative mutations in VWF gene. (19277422)	Corrales I.... Vidal F.	2009	VWF
4	Laboratory diagnosis and molecular basis of mild von Willebrand disease type 1. (19506353)	Michiels J.J.... van Vliet H.H.	2009	VWF, F8
5	Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease. (19786936)	Batlle J.... PAcrez-RodrA-guez M.A.	2009	F8
6	An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary. (18665926)	Mohl A.... Schneppenheim R.	2008	VWF
7	von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). (18315614)	Nichols W.L.... Yawn B.P.	2008	VWF
8	Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD). (18315556)	Budde U.... Peake I.	2008	VWF
9	Genetics of type 1 von Willebrand disease. (17934350)	Goodeve A.	2007	VWF
10	Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand's disease by flow cytometry. (18055988)	Giannini S.... Gresele P.	2007	VWF
11	Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD). (16985174)	Goodeve A.... Peake I.	2007	VWF
12	Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival. (16835381)	Haberichter S.L.... Montgomery R.R.	2006	VWF
13	External peer review quality assurance testing in von Willebrand disease: the recent experience of the United States College of American Pathologists proficiency testing program. (16862523)	Hayes T.E.... Cunningham M.T.	2006	VWF
14	Composition, quality control, and labeling of plasma-derived products for the treatment of von Willebrand disease. (16862527)	Mazurier C.	2006	VWF
15	Laboratory testing for von Willebrand disease: contribution of multimer analysis to diagnosis and classification. (16862525)	Budde U.... Schneppenheim R.	2006	F3
16	Management of inherited von Willebrand disease in 2006. (16977571)	Federici A.B.	2006	VWF, F8
17	Laboratory identification of von Willebrand disease: technical and scientific perspectives. (16862518)	Favaloro E.J.	2006	VWF, F8
18	Effect of desmopressin (DDAVP) on platelet membrane glycoprotein expression in patients with von Willebrand's disease. (15764817)	Gordz S.... Jung F.	2005	SELP
19	Theoretical structural explanation for Group I and Group II, type 2A von Willebrand disease mutations. (15842374)	O'Brien L.A.... Lillicrap D.	2005	VWF
20	Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease. (15705799)	Othman M.... O'Shaughnessy D.F.	2005	GP1BA
21	Recombinant expression of mutations causing von Willebrand disease type Normandy: characterization of a combined defect of factor VIII binding and multimerization. (15213842)	Schneppenheim R.... Budde U.	2004	VWF, F8
22	A novel type 2A (Group II) von Willebrand disease mutation (L1503Q) associated with loss of the highest molecular weight von Willebrand factor multimers. (15219197)	O'Brien L.A.... Lillicrap D.	2004	VWF
23	Expression of two type 2N von Willebrand disease mutations identified in exon 18 of von Willebrand factor gene. (15461624)	Hilbert L.... Mazurier C.	2004	VWF, F8
24	Diagnostic standards of von Willebrand disease (15029269)	Budde U.... Schneppenheim R.	2004	VWF
25	Von Willebrand's disease in the year 2003: towards the complete identification of gene defects for correct diagnosis and treatment. (12551832)	Castaman G.... Mannucci P.M.	2003	VWF, F8
26	Response of von Willebrand factor parameters to desmopressin in patients with type 1 and type 2 congenital von Willebrand disease: diagnostic and therapeutic implications. (11992235)	Michiels J.J.... Berneman Z.	2002	VWF
27	Acquired von Willebrand disease--hemostatic managemen t of major orthopedic surgery with high-dose immunoglobulin, desmopressin, and continuous factor concentrate infusion. (11994985)	Frank R.D.... Wirtz D.C.	2002	VWF
28	Perioperative therapy of von Willebrand disease. Dem onstration of pathophysiology, clinical problems and therapy options using two case reports (12395174)	Kleinschmidt S.... MAPrsdorf S.	2002	VWF
29	Von Willebrand's disease caused by compound heterozygosity for a substitution mutation (T1156M) in the D3 domain of the von Willebrand factor and a stop mutation (Q2470X). (12353070)	Lethagen S.... Holmberg L.	2002	VWF
30	Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6. (10959689)	Newby D.E.... Ludlam C.A.	2000	VWF, PLAT
31	The platelet function analyzer (PFA-100) may not be suitable for monitoring the therapeutic efficiency of von willebrand concentrate in type III von willebrand disease. (10525831)	Meskal A.... Berneman Z.N.	1999	F8
32	Analysis of von Willebrand factor in platelets of pat ients with various forms of von Willebrand disease: is there a clinical relevan ce? (10650864)	Kertzscher F.... Lenk H.	1999	VWF, F8
33	Idiopathic immune-mediated acquired von Willebrand's disease in a patient with angiodysplasia: demonstration of an unusual inhibitor causing a functional defect and rapid clearance of von Willebrand factor. (9929110)	Alhumood S.A.... Carter C.J.	1999	VWF, F3
34	von Willebrand factor contained in factor VIII concen trates of different purities supports platelet adhesion in blood samples from a heterogeneous group of patients with von Willebrand disease. (9864923)	Escolar G.... Aznar-Salatti J.	1998	F8
35	The revised classification of von Willebrand disease including the previously masqueraded female hemophilia A (type 2N) (9220657)	Nishino M.... Yoshioka A.	1997	VWF
36	Different organization of von Willebrand factor oligomers in type-2A and -2B von Willebrand disease variants: effects of DDAVP infusion and protease inhibitors. (7578526)	Casonato A.... Girolami A.	1995	VWF
37	Hemophilia and von Willebrand's disease: 2. Management. Association of Hemophilia Clinic Directors of Canada. (7600466)		1995	F9
38	Hemophilia and von Willebrand's disease: 1. Diagnosis, comprehensive care and assessment. Association of Hemophilia Clinic Directors of Canada. (7796372)		1995	F9
39	Substitution of Val for Met at residue 239 of platelet glycoprotein Ib alpha in Japanese patients with platelet-type von Willebrand disease. (7833477)	Takahashi H.... Watanabe K.	1995	GP1BA
40	Laboratory assessment of von Willebrand factor. Use o f different assays can influence the diagnosis of von Willebrand's disease, dep endent on differing sensitivity to sample preparation and differential recognit ion of high molecular weight VWF forms. (7677113)	Favaloro E.J.... Grispo L.	1995	VWF
41	The use of intermediate and high purity factor VIII products in the treatment of von Willebrand disease. (8191394)	Hanna W.T.... Rickles F.R.	1994	VWF
42	Secretory response of the vessel wall to DDAVP and venous occlusion in von Willebrand's disease. (7992599)	Bykowska K.... Lopaciuk S.	1994	VWF, PLAT
43	Glanzmann's thrombasthenia with mild von Willebrand's disease. (8282841)	Nounou R.... Spence D.	1993	F2, F3
44	Alpha granule proteins in type I von Willebrand's disease. (8438875)	McKeown L.P.... Gralnick H.R.	1993	VWF, PPBP, PF4
45	Two new candidate mutations in type IIA von Willebrand's disease (Arg834-->Gly, Gly846-->Arg) and one polymorphism (Tyr821-->Cys) in the A2 region of the von Willebrand factor. (8348943)	Donner M.... Holmberg L.	1993	VWF
46	Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment. (8486780)	Murata M.... Ware J.	1993	VWF, GP1BA
47	New variant of von Willebrand disease type II with markedly increased levels of von Willebrand factor antigen and dominant mode of inheritance: von Willebrand disease type IIC Miami. (8324222)	Ledford M.R.... Civantos F.	1993	VWF
48	The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor. (1732004)	Jorieux S.... Sadler J.E.	1992	F8
49	Replacement therapy with virus-inactivated plasma con centrates in von Willebrand disease. (1642002)	Rodeghiero F.... Mannucci P.M.	1992	F8
50	Mutations in severe, type III von Willebrand's disease in the Dutch population: candidate missense and nonsense mutations associated with reduced levels of von Willebrand factor messenger RNA. (1448779)	Eikenboom J.C.... Briet E.	1992	VWF

Genes related to von willebrand's disease according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	VWF	von Willebrand factor	11.1	Summaries, Publications
2	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.1	Summaries, Publications
3	F8	coagulation factor VIII, procoagulant component	11.0	Publications
4	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
5	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	11.0	Publications
6	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
7	F11	coagulation factor XI	11.0	Publications
8	CD63	CD63 molecule	11.0
9	F9	coagulation factor IX	11.0	Publications
10	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0
11	IL11	interleukin 11	11.0	Publications
12	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0
13	PLAT	plasminogen activator, tissue	11.0	Publications
14	ADAMTSL1	ADAMTS-like 1	11.0
15	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
16	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
17	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
18	F2	coagulation factor II (thrombin)	11.0	Publications
19	DUSP28	dual specificity phosphatase 28	11.0
20	GP9	glycoprotein IX (platelet)	11.0	Publications
21	PDIA4	protein disulfide isomerase family A, member 4	11.0	Publications
22	MMRN1	multimerin 1	11.0	Publications
23	PDIA3	protein disulfide isomerase family A, member 3	11.0	Publications
24	CFB	complement factor B	11.0	Publications
25	COL11A2	collagen, type XI, alpha 2	11.0	Publications
26	CPB2	carboxypeptidase B2 (plasma)	11.0	Publications
27	GP6	glycoprotein VI (platelet)	11.0	Publications
28	CALR	calreticulin	11.0	Publications
29	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
30	HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	11.0	Publications
31	PF4	platelet factor 4	11.0	Publications
32	LRPAP1	low density lipoprotein receptor-related protein associated protein 1	11.0	Publications
33	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.0	Publications
34	LRP1	low density lipoprotein receptor-related protein 1	11.0	Publications
35	ANO2	anoctamin 2	11.0	Publications
36	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
37	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	11.0	Publications
38	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
39	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	11.0	Publications
40	PLAU	plasminogen activator, urokinase	11.0	Publications
41	IFNA1	interferon, alpha 1	11.0	Publications
42	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications

Pathways related to von willebrand's disease according to GeneDecks:

(show all 38)

id	Pathway	Score	Top Affiliating Genes
1	Warfarin Pathway, Pharmacodynamics34	10.4	F2, F7, F9
2	Response to elevated platelet cytosolic Ca2+38	10.3	CD63, MMRN1, F8
3	Cell surface interactions at the vascular wall38	10.2	F2, GP6, SELP
4	Common Pathway38	10.0	SERPINC1, F5
5	Akt Signaling36	10.0	PF4, IL11, ITGA2B, ITGA2
6	PTEN Pathway36	9.9	COL11A2, PPBP, ITGA2B, ITGA2
7	Dissolution of Fibrin Clot38	9.9	PLAT, PLAU
8	Platelet activation, signaling and aggregation38	9.9	VWF, PPBP, PF4
9	Extrinsic Prothrombin Activation Pathway36	9.8	F2, F3, F5, F7, SERPINC1
10	Hematopoietic cell lineage20	9.6	GP1BA, GP9, IL11, ITGB3, ITGA2B, ITGA2
11	Cell adhesion_Integrin inside-out signaling41	9.6	ITGA2, ITGB1, ITGB3
12	Protein processing in endoplasmic reticulum20	9.6	PDIA4, PDIA3, CALR, HSP90B1, HSPA5
13	Intrinsic Prothrombin Activation Pathway36	9.5	COL11A2, F11, F2, F5, F8, F9
14	Regulation of actin cytoskeleton20	9.4	ITGA2, ITGA2B, ITGB1
15	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	9.4	ITGB3, ITGB1, ITGA2B, ITGA2
16	Phagocytosis of Microbes36	9.4	ITGB3, ITGB1, ITGA2B, ITGA2
17	Hypertrophic cardiomyopathy (HCM)20	9.4	ITGA2, ITGA2B, ITGB1, ITGB3
18	HGF Pathway36	9.4	ITGB3, ITGB1, ITGA2B, ITGA2
19	ERK Signaling36	9.4	PF4, COL11A2, PPBP, IL11, ITGB1, ITGA2B
20	Glioma Invasiveness36	9.3	PLAU, PPBP, ITGB1, ITGA2B
21	Dilated cardiomyopathy20	9.3	ITGB3, ITGB1, ITGA2B, ITGA2
22	Cell adhesion Integrin inside-out signaling10	9.3	F2, ITGB3, ITGB1, ITGA2B, ITGA2
23	Blood Coagulation Cascade36	9.3	COL11A2, F11, F2, F3, F5, F7
24	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.3	F2, GP6, GP9, ITGB3, ITGA2B, ITGA2
25	Reelin Pathway (Cajal-Retzius cells)36	9.2	ITGB3, ITGB1, ITGA2B, ITGA2
26	FAK1 Signaling36	9.2	ITGA2, ITGA2B, ITGB1, ITGB3, COL11A2
27	Regulation of eIF4 and p70S6K36	9.2	IL11, ITGB3, ITGB1, ITGA2B, ITGA2
28	Focal adhesion20	9.2	COL11A2, ITGB3, ITGB1, ITGA2B, ITGA2, VWF
29	PPAR Pathway36	8.9	PPBP, ITGB3, ITGB1, ITGA2B, ITGA2
30	Integrin Pathway36	8.9	COL11A2, ITGB3, ITGB1, ITGA2B, ITGA2
31	Transendothelial Migration of Leukocytes36	8.8	PF4, COL11A2, F2, ITGB3, ITGB1, ITGA2B
32	Calpain Protease Regulates Cellular Mechanics36	8.8	ITGB3, ITGB1, ITGA2B, ITGA2
33	Molecular Mechanisms of Cancer36	8.8	PF4, COL11A2, PPBP, IL11, ITGB1, ITGA2B
34	ECM-receptor interaction20	8.7	COL11A2, GP6, GP1BA, GP9, ITGB3, ITGB1
35	UPA-UPAR Pathway36	8.6	ITGB1, ITGB3, PLAU, COL11A2, ITGA2B, ITGA2
36	Rho Family GTPases36	8.6	PF4, COL11A2, PPBP, IL11, ITGB3, ITGB1
37	Complement and coagulation cascades20	8.3	CPB2, SERPINC1, CFB, F9, F8, F7
38	Blood Coagulation Signaling Pathways37	8.2	PLAU, PLAT, VWF, SERPINC1, GP9, GP1BA

Compounds related to von willebrand's disease according to GeneDecks:

(show top 50)    (show all 224)

id	Compound	Score	Top Affiliating Genes
1	abciximab32 9 9	12.4	VWF, ITGA2B, F2, F3
2	lysine32	9.9	PF4, PLAU
3	clopidogrel32 34 9 18 9	13.9	SERPINC1, P2RY12, CD63, PPBP
4	phosphatidylserine32 9 9	11.6	ADAMTSL1, F2, CALR, VWF, GP1BA, GP6
5	hydroxyethyl starch32	9.6	F2, F3, F8, SERPINC1
6	citrate32	9.6	SELP, F9, F8, PPBP, PF4, PIK3C2A
7	ppack32	9.5	P2RY12, SELP, F2, VWF, PLAT, F3
8	glucose32	9.5	CFB, ITGA2, IL11, GP1BA, HSP90B1, CALR
9	fondaparinux32	9.4	SERPINC1, F9, F5, F3, F2, PLAT
10	bivalirudin32 9 9	11.4	F3, F5, SERPINC1, SELP, F2, PLAT
11	argatroban32 9 9	11.3	F2, SELP, F3, F5, SERPINC1, PLAT
12	ptca32	9.2	SELP, F3, PPBP, PIK3C2A, PLAT, ADAMTSL1
13	ticlopidine32 9 9	11.2	ADAMTS13, VWF, SELP, SERPINC1, P2RY12, F3
14	tranexamic acid32 9 9	11.1	F9, F8, F3, F2, PLAT, PLAU
15	protamine32	9.0	SERPINC1, F5, SELP, PLAT, F3, ADAMTSL1
16	epsilon aminocaproic acid32	8.9	F2, PLAU, PLAT, F3, F9, ADAMTSL1
17	hirudin32	8.9	SERPINC1, GP1BA, F9, F5, F11, PLAU
18	thromboxane32 18	9.9	PIK3C2A, VWF, SELP, PF4, PLAT, PPBP
19	thromboxane a232 18	9.8	GP6, F8, PPBP, PLAT, PF4, ITGA2
20	protamine sulfate32	8.8	SERPINC1, F5, F3, F2, PLAT, PF4
21	aspartate32	8.7	PIK3C2A, SELP, IL11, GP9, F9, F8
22	dextran sulfate32	8.6	F3, PF4, PLAU, F11, F5, ADAMTSL1
23	pge132	8.6	F2, F5, IL11, P2RY12, VWF, PIK3C2A
24	dermatan sulfate32	8.5	F3, F2, F11, PLAT, PLAU, PF4
25	homocysteine32 18	9.4	SERPINC1, MTHFR, F9, F8, F5, F3
26	tirofiban32 9 9	10.4	VWF, SELP, SERPINC1, P2RY12, ITGA2, ITGA2B
27	warfarin32 34 9 18 9	12.3	PLAT, PF4, PPBP, F2, F3, PIK3C2A
28	desmopressin32 42 9 9	11.2	F11, PPBP, PLAT, PLAU, ADAMTS13, F2
29	kininogen32	8.1	F11, PLAT, PLAU, PF4, ADAMTSL1, F2
30	ristocetin32	8.0	VWF, SELP, SERPINC1, ITGB3, GP9, GP1BA
31	aprotinin32 9 9	10.0	LRP1, VWF, SELP, SERPINC1, GP1BA, F9
32	prostacyclin32	8.0	PIK3C2A, VWF, SELP, SERPINC1, GP1BA, F8
33	epinephrine32 9 18 9	10.7	GP6, F8, F5, F3, F2, PPBP
34	polysaccharide32	7.5	HSPA5, ADAMTSL1, PDIA3, PF4, PLAU, SELP
35	cyclosporin a32 42	8.4	F9, PIK3C2A, IFNA1, SELP, MTHFR, ITGB1
36	lactate32	7.4	HSPA5, F2, F8, GP1BA, CD63, SELP
37	cholesterol32 9 18 9	10.3	PF4, CPB2, ADAMTSL1, PLAT, PPBP, HSPA5
38	cysteine32	7.2	LRP1, SELP, MTHFR, ITGA2B, ITGB1, IL11
39	heparin32 9 18 9	10.2	PLAU, ADAMTS13, ADAMTSL1, PPBP, CALR, F11
40	aspirin32 34 18	9.1	PLAT, PLAU, PF4, ADAMTSL1, PPBP, F2
41	creatinine32	7.0	PIK3C2A, PF4, CPB2, ADAMTS13, PLAU, PLAT
42	arginine32	6.4	F5, PIK3C2A, F9, GP6, ITGA2, SERPINC1
43	adp32 18	7.2	SELP, HSPA5, HSP90B1, PPBP, PLAT, PF4
44	alanine32	6.1	F9, F5, F2, PPBP, PLAU, PF4
45	lipid32	5.9	P2RY12, LRP1, LRPAP1, HSPA5, CD63, ITGA2
46	vegf32	5.1	PIK3C2A, LRP1, VWF, SELP, SERPINC1, IL11
47	tyrosine32	4.7	IL11, ITGB3, ITGB1, ITGA2, CD63, P2RY12
48	calcium32 9 18 9	7.7	ITGA2, ITGA2B, ITGB1, ITGB3, IL11, ANO2
49	fibrinogen32	4.3	ADAMTS13, ADAMTSL1, PIK3C2A, VWF, SELP, SERPINC1
50	serine32	3.8	PLAU, ADAMTS13, ADAMTSL1, PLAT, GP6, IFNA1

Cellular components related to von willebrand's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.6	PF4, PPBP, F5, F8, MMRN1, VWF
2	platelet alpha granule membrane	GO:031092	9.5	SELP, ITGA2B, ITGB3
3	external side of plasma membrane	GO:009897	9.1	ITGB1, ITGA2B, ITGA2, SELP, VWF, CALR
4	integrin complex	GO:008305	9.0	ITGB3, ITGB1, ITGA2B, ITGA2
5	endoplasmic reticulum lumen	GO:005788	8.8	PDIA4, PDIA3, COL11A2, CALR, HSP90B1, HSPA5
6	melanosome	GO:042470	8.5	PDIA4, PDIA3, HSP90B1, HSPA5, ITGB3, ITGB1
7	cell surface	GO:009986	7.8	ADAMTS13, PLAU, PLAT, CALR, HSPA5, ITGB1
8	extracellular space	GO:005615	7.4	SELP, ADAMTS13, CPB2, PF4, PLAU, PLAT
9	extracellular region	GO:005576	7.0	F2, F11, PPBP, PLAT, PLAU, COL11A2
10	plasma membrane	GO:005886	5.2	GP1BA, GP6, F9, F8, F7, F5

Biological processes related to von willebrand's disease according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation, extrinsic pathway	GO:007598	10.3	F9, F7, F3
2	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:010641	10.2	F7, F3
3	peptidyl-glutamic acid carboxylation	GO:017187	10.2	F9, F7, F2
4	sequestering of calcium ion	GO:051208	10.0	HSP90B1, CALR
5	blood coagulation, intrinsic pathway	GO:007597	9.9	F11, F2, F8, F9, GP1BA, GP9
6	smooth muscle cell migration	GO:014909	9.6	ITGB3, PLAT
7	post-translational protein modification	GO:043687	9.6	PDIA3, CALR, F2, F7, F9
8	fibrinolysis	GO:042730	9.5	CPB2, PLAU, PLAT, F2, GP1BA
9	integrin-mediated signaling pathway	GO:007229	9.2	ADAMTS13, ITGB3, ITGB1, ITGA2B, ITGA2
10	cell-matrix adhesion	GO:007160	9.1	ADAMTS13, ITGB3, ITGB1, ITGA2B, ITGA2
11	leukocyte migration	GO:050900	9.0	F2, GP6, ITGB3, ITGB1, SELP
12	proteolysis	GO:006508	8.9	ADAMTS13, CPB2, PLAU, PLAT, F11, F2
13	cell adhesion	GO:007155	8.9	F5, F8, GP1BA, GP9, MMRN1, ITGB3
14	platelet degranulation	GO:002576	8.5	PF4, PPBP, HSPA5, F5, F8, MMRN1
15	platelet activation	GO:030168	7.5	F2, F5, F8, GP6, GP1BA, GP9
16	blood coagulation	GO:007596	5.0	GP1BA, GP9, MMRN1, ITGB3, ITGB1, ITGA2B

Molecular functions related to von willebrand's disease according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein disulfide isomerase activity	GO:003756	9.8	ITGB3, PDIA3, PDIA4
2	glycoprotein binding	GO:001948	9.7	F7, ITGB1, SELP, VWF
3	collagen binding	GO:005518	9.4	GP6, ITGB1, ITGA2, VWF
4	protease binding	GO:002020	9.2	VWF, SERPINC1, ITGB1, F3
5	integrin binding	GO:005178	9.2	VWF, ITGB1, CALR, ADAMTS13
6	serine-type endopeptidase activity	GO:004252	9.2	CFB, PLAU, PLAT, F11, F2, F7
7	heparin binding	GO:008201	9.1	PF4, F11, SERPINC1, SELP, LRPAP1
8	calcium ion binding	GO:005509	8.8	CALR, HSP90B1, HSPA5, F2, F7, F9
9	protein binding	GO:005515	5.1	F2, F11, HSPA5, HSP90B1, CALR, PLAT