MCID: VLV044
MIFTS: 42

Vulvar Intraepithelial Neoplasia malady

Reproductive diseases, Cancer diseases categories

Summaries for Vulvar Intraepithelial Neoplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin... more...

MalaCards: Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to squamous cell carcinoma and papilloma. An important gene associated with Vulvar Intraepithelial Neoplasia is KRT5 (keratin 5), and among its related pathways are Glioma and Cell Cycle. The compounds (4-aminophenyl)mercuric acetate and doxycycline have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

vulvar intraepithelial neoplasia 48
vulval intraepithelial neoplasia 60
vulvar intraepithelial tumor 48


External Ids:

SNOMED-CT via Orphanet57 399933001

Related Diseases for Vulvar Intraepithelial Neoplasia

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17GeneCards, 18GeneDecks
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Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.3CCND1, CDKN2A, CD44, MMP2, MMP1, MMP9
2papilloma30.6CDKN2A, KRT5, TP53
3herpes simplex30.3TIMP2
4skin disease30.3MMP9
5cervical cancer30.3TIMP2, CDKN2A, CD44, MMP2, BIRC5, TERT
6melanoma30.3CD44, CDKN2A, CCND1, TIMP1, TIMP2, MMP2
7cervicitis10.7
8vulva squamous cell carcinoma10.7
9vulvar disease10.6
10vulva cancer10.5
11vulvar keratinizing squamous cell carcinoma10.4
12vulvovaginitis10.4
13keratinizing squamous cell carcinoma10.4
14in situ carcinoma10.4
15epidermodysplasia verruciformis10.3
16systemic lupus erythematosus10.2
17vulvar melanoma10.2
18acne10.2
19lupus erythematosus10.2
20vascular cancer10.2
21chordoma10.0KRT5
22psoriasis10.0KRT5
23myelodysplastic syndromes10.0BIRC5
24meningioma10.0TERT
25chondrosarcoma10.0MMP1
26myeloid leukemia10.0BIRC5
27galactosemia10.0TIMP1
28pheochromocytoma10.0TERT
29liver cirrhosis10.0TIMP1
30epidermolysis bullosa10.0KRT5
31hepatitis b10.0TERT
32fibromatosis10.0TIMP2
33hypertensive heart disease10.0MMP1
34cholesteatoma10.0MMP9
35hypertension10.0MMP9
36nijmegen breakage syndrome10.0H2AFX
37abdominal aortic aneurysm10.0MMP9
38bronchopulmonary dysplasia10.0TIMP1
39cervical adenocarcinoma10.0CDKN2A
40hepatoblastoma10.0BIRC5
41dilated cardiomyopathy10.0MMP1
42meningitis10.0MMP9
43renal clear cell carcinoma10.0BIRC5
44gallbladder cancer10.0TP53
45ulcerative colitis10.0TP53
46neuroblastoma10.0TP53
47parathyroid carcinoma10.0CCND1
48gastritis10.0TP53
49actinic keratosis10.0TP53
50leiomyosarcoma10.0TP53

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to vulvar intraepithelial neoplasia

Clinical Features for Vulvar Intraepithelial Neoplasia

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Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Vulvar Intraepithelial Neoplasia

Drug clinical trials:

Search ClinicalTrials for Vulvar Intraepithelial Neoplasia

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Search CenterWatch for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

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Anatomical Context for Vulvar Intraepithelial Neoplasia

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32MalaCards
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MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

32
Skin

Animal Models for Vulvar Intraepithelial Neoplasia or affiliated genes

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36MGI
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Publications for Vulvar Intraepithelial Neoplasia

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Genetic Variations for Vulvar Intraepithelial Neoplasia

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Expression for genes affiliated with Vulvar Intraepithelial Neoplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for genes affiliated with Vulvar Intraepithelial Neoplasia

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Sources:
29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TP53
210.0H2AFX
310.0BIRC5, MMP1
49.9BIRC5, MMP2
59.8MMP9, MMP1
6
Hide members
9.5TIMP2, TIMP1, MMP2
79.5MMP1, KRT5, TP53
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.5MMP1, CCND1, TIMP1
99.5CCND1, MMP2, BIRC5
10
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.4TIMP1, MMP1, TP53
11
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9.4TP53, BIRC5, CCND1
129.3MMP9, MMP2, CCND1
13
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9.3CCND1, MMP1, TP53
14
Transcription P53 signaling pathway
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9.3TP53, MMP2, CDKN2A
15
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9.3TP53, CDKN2A, CCND1
169.3TP53, CDKN2A, CCND1
17
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9.3TP53, CDKN2A, CCND1
189.3TP53, MMP9, CCND1
19
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9.2CCND1, CDKN2A, H2AFX
209.2TIMP2, TIMP1, MMP2, MMP9
219.2TIMP2, TIMP1, MMP2, MMP9
229.2TP53, TERT, BIRC5, MMP9
239.1MMP9, MMP2, CD44
249.1TP53, H2AFX, CCND1
259.1TP53, CD44, CDKN2A
269.1MMP9, MMP1, MMP2, CCND1
27
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9.0TP53, BIRC5, MMP9, CCND1
289.0CCND1, CDKN2A, TERT, TP53
29
Cell adhesion Cell-matrix glycoconjugates
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9.0TIMP2, CD44, MMP1, MMP9
30
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8.9TIMP2, TIMP1, MMP2, MMP1, MMP9
31
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8.8TIMP2, TIMP1, MMP2, MMP1, TP53
328.3CCND1, CDKN2A, CD44, MMP9, TP53
33
Hide members
8.3TIMP2, TIMP1, CD44, MMP2, MMP1, MMP9
34
Cell adhesion ECM remodeling
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8.3MMP9, MMP1, MMP2, CD44, TIMP1, TIMP2
358.3CCND1, CD44, MMP2, MMP9, TP53
36
Hide members
8.2TIMP2, TIMP1, CCND1, SOX2, CDKN2A, TP53
37
Hide members
8.1TP53, CD44, CDKN2A, SOX2, CCND1
388.0CCND1, CDKN2A, MMP2, MMP1, MMP9, BIRC5
39
Hide members
7.5TIMP2, TIMP1, CDKN2A, CD44, MMP2, MMP9

Compounds for genes affiliated with Vulvar Intraepithelial Neoplasia

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4410.6TIMP1
2doxycycline44 1111.3MMP1
3matrigel4410.2MMP1, CCND1
4methyl selenol449.6TIMP2, MMP2, MMP9, TIMP1
5pdtc449.5MMP2, MMP1, MMP9
6norcantharidin449.5BIRC5, TIMP2, CCND1, MMP2
7latanoprost44 1110.3TIMP2, TIMP1, MMP2, MMP1, MMP9
8hydroxamate449.3TIMP1, TIMP2, MMP1, MMP9, MMP2
91,10-phenanthroline44 210.3TIMP1, TIMP2, MMP2, MMP1, MMP9
10batimastat44 59 1111.2MMP1, MMP2, TIMP1, TIMP2, MMP9
11depsipeptide449.2TP53, CDKN2A, CCND1, H2AFX
12hydroxyproline44 11 2411.1MMP9, TIMP2, MMP2, TIMP1, MMP1
13silymarin449.1BIRC5, MMP9, MMP2, CCND1, TIMP2
14etoposide44 49 59 1112.1CD44, H2AFX, TERT, TIMP1
15vitamin a44 11 2411.1KRT5, TIMP1, MMP2, BIRC5, MMP9, MMP1
16p00001449.0BIRC5, CD44, TIMP2, CDKN2A, CCND1
17guanine44 11 2410.9CCND1, VWF
18celecoxib44 59 28 49 11 2413.9MMP9, MMP2, MMP1, CCND1, BIRC5
19arsenite44 249.9CCND1, CDKN2A, MMP9, TP53, BIRC5, TERT
20pioglitazone44 49 28 1111.8MMP9, TIMP1, MMP1, TIMP2, MMP2
21h2o2448.8MMP2, TIMP2, CDKN2A, VWF, MMP1
22roscovitine448.8TP53, CDKN2A, CCND1, H2AFX, BIRC5
23aprotinin44 119.5MMP9, VWF, MMP1, MMP2, TIMP2, TIMP1
24curcumin448.5TP53, BIRC5, MMP9, MMP1, MMP2, CCND1
25adriamycin448.4TERT, TP53, BIRC5, CD44, CCND1, CDKN2A
26pd 98,059448.4MMP2, MMP1, MMP9, TERT, CCND1, TIMP1
2712-o-tetradecanoylphorbol 13-acetate448.4TIMP2, TIMP1, CD44, MMP2, MMP1, MMP9
28methotrexate44 49 1110.4MMP1, CDKN2A, MMP2, MMP9, BIRC5, TIMP1
29sb 20358044 599.2MMP9, TP53, CCND1, TIMP2, MMP1, MMP2
30actinomycin d448.1CDKN2A, CD44, MMP9, BIRC5, TP53, TIMP2
31folate448.1VWF, MMP9, MMP2, CDKN2A, CCND1, TIMP1
32nicotine44 49 28 1111.1MMP2, CDKN2A, MMP1, MMP9, VWF, BIRC5
33paclitaxel44 49 1110.0TP53, BIRC5, TIMP2, TIMP1, CCND1, CDKN2A
34genistein44 28 59 2 11 2412.9TERT, CCND1, MMP2, TIMP2, MMP9, MMP1
35cytochalasin d44 598.9VWF, MMP9, TIMP2, TIMP1, CD44, MMP2
36hyaluronic acid44 248.9TIMP1, CD44, MMP2, MMP1, MMP9, VWF
37doxorubicin44 49 119.7CCND1, H2AFX, BIRC5, TERT, TP53, MMP1
38cisplatin44 49 59 1110.7CD44, CCND1, TIMP1, H2AFX, BIRC5, TERT
39serine447.6TIMP2, TIMP1, CCND1, CD44, MMP2, MMP1
40lactate447.6VWF, BIRC5, MMP9, CD44, TIMP1, TIMP2
41oligonucleotide447.4CCND1, TIMP2, TERT, TP53, CDKN2A, MMP1
42progesterone44 59 28 11 2411.4MMP1, CD44, BIRC5, TIMP2, TIMP1, TP53
43alanine447.2CDKN2A, KRT5, TIMP1, CD44, BIRC5, MMP2
44paraffin447.2TERT, KRT5, BIRC5, VWF, MMP1, MMP2
45ly294002447.1TIMP1, TIMP2, TERT, H2AFX, TP53, MMP9
46cysteine447.0CDKN2A, TIMP1, TERT, CD44, MMP2, MMP9
47testosterone44 59 11 2410.0KRT5, CDKN2A, CCND1, CD44, TERT, BIRC5
48n acetylcysteine446.6CCND1, TIMP1, TERT, BIRC5, CDKN2A, TP53
49vegf446.2TIMP2, TIMP1, CCND1, CDKN2A, MMP9, VWF
50retinoic acid44 246.5CD44, CDKN2A, SOX2, TIMP1, TIMP2, CCND1

GO Terms for genes affiliated with Vulvar Intraepithelial Neoplasia

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16Gene Ontology
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Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:0056579.5TP53, H2AFX
2proteinaceous extracellular matrixGO:0055788.4VWF, MMP9, MMP1, MMP2

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.6TP53, CCND1
2response to X-rayGO:0101659.6TP53, CCND1
3positive regulation of cell cycle arrestGO:0711589.6CDKN2A, TP53
4replicative senescenceGO:0903999.5CDKN2A, TERT, TP53
5collagen catabolic processGO:0305749.5MMP9, MMP1, MMP2
6extracellular matrix disassemblyGO:0226179.1MMP9, MMP1, MMP2, TIMP1, TIMP2
7cell cycle arrestGO:0070508.9TP53, CDKN2A, SOX2
8extracellular matrix organizationGO:0301988.4TIMP2, TIMP1, CD44, MMP2, MMP1, MMP9

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.9TIMP1, TIMP2
2MDM2/MDM4 family protein bindingGO:0973719.7TP53, CDKN2A
3metalloendopeptidase activityGO:0042229.2MMP9, MMP1, MMP2
4chaperone bindingGO:0510879.1VWF, BIRC5, TP53
5collagen bindingGO:0055188.8VWF, MMP9, CD44
6enzyme bindingGO:0198998.7CCND1, H2AFX, BIRC5, TP53
7protein bindingGO:0055155.2TP53, TIMP1, CCND1, SOX2, CDKN2A, CD44

Products for genes affiliated with Vulvar Intraepithelial Neoplasia

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  • Antibodies
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Sources for Vulvar Intraepithelial Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet