MCID: VLV044
MIFTS: 48

Vulvar Intraepithelial Neoplasia malady

Reproductive diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

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Sources:
48Orphanet, 61UMLS, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 48
Vulval Intraepithelial Neoplasia 61
 
Vulvar Intraepithelial Tumor 48


Classifications:



External Ids:

Orphanet48 137583
UMLS via Orphanet62 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

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Wikipedia:64 The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin... more...

MalaCards based summary: Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to cervical intraepithelial neoplasia and papilloma. An important gene associated with Vulvar Intraepithelial Neoplasia is KRT5 (keratin 5), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Glucocorticoid receptor regulatory network. The compounds latanoprost and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are taste/olfaction and pigmentation.

Related Diseases for Vulvar Intraepithelial Neoplasia

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Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia31.1CDKN2A, BIRC5, TERT
2papilloma31.0CDKN2A, KRT5, TP53
3melanoma28.0CTNNB1, CD44, CDH1, CDKN2A, BIRC5, CCND1
4cervicitis10.8
5lichen sclerosus10.7
6meningioma, familial10.6TERT
7vulvovaginitis10.5
8blindness10.5
9chronic ulcer of skin10.4MMP1, TIMP2
10actinic keratosis10.4TP53
11mismatch repair cancer syndrome10.4CTNNB1
12arthropathy10.4MMP1, TIMP1
13oral submucous fibrosis10.4MMP1, TIMP1
14oral lichen planus10.4MMP1, TIMP2
15pulpitis10.4MMP1, TIMP1
16tonsil squamous cell carcinoma10.4CDKN2A, CCND1
17craniopharyngioma10.4CTNNB1
18fibromatosis10.3CTNNB1, TIMP2
19benign meningioma10.3BIRC5, TERT
20fibromatosis, gingival10.3MMP1, MMP2
21thoracic aortic aneurysm10.3MMP1, MMP2
22gingival overgrowth10.3MMP1, TIMP1
23synovitis10.3MMP1, TIMP1, TIMP2
24carotid stenosis10.3MMP1, MMP9
25systemic lupus erythematosus10.3
26acne10.3
27amyloidosis10.3
28herpes simplex10.3
29lupus erythematosus10.3
30vulva cancer10.3
31vulvar disease10.3
32trichofolliculoma10.3
33endotheliitis10.3
34multiple myeloma10.3CD44, CCND1
35middle ear cholesteatoma10.3MMP1, MMP9
36lymphangioleiomyomatosis10.3MMP1, MMP2
37benign mesothelioma10.3KRT5, TP53
38gallbladder adenoma10.3CTNNB1, CDKN2A
39oropharynx cancer10.3CDKN2A, TP53
40periodontitis10.3MMP9
41li-fraumeni syndrome10.3CDKN2A, TP53
42pulmonary emphysema10.2MMP1, MMP9, TIMP2
43relapsing-remitting multiple sclerosis10.2MMP9, TIMP1
44gingivitis10.2MMP1, TIMP1
45malignant peripheral nerve sheath tumor10.2CD44, CDKN2A, TERT
46keratoconus10.2MMP1, MMP2, TIMP1
47periodontal disease10.2MMP1, MMP2, TIMP1
48glomerulosclerosis10.2MMP2, TIMP1, TIMP2
49pulmonary disease, chronic obstructive10.2MMP9, TIMP1
50microvascular complications of diabetes 110.2MMP9, TIMP1, TIMP2

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to vulvar intraepithelial neoplasia

Symptoms for Vulvar Intraepithelial Neoplasia

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Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

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Drug clinical trials:

Search ClinicalTrials for Vulvar Intraepithelial Neoplasia

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

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Anatomical Context for Vulvar Intraepithelial Neoplasia

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MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

31
Skin, T cells, Testes, Lung, Endothelial

Animal Models for Vulvar Intraepithelial Neoplasia or affiliated genes

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MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

35 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2CTNNB1, SOX2, TERT
2MP:00011868.6TP53, SOX2, CDKN2A, CTNNB1
3MP:00053718.2MMP9, KRT5, CD44, CTNNB1, TP53
4MP:00053828.1TP53, SOX2, CCND1, KRT5, CTNNB1, MMP2
5MP:00053697.7CD44, CDKN2A, MMP2, MMP9, SOX2, TP53
6MP:00053807.5CTNNB1, CDH1, CDKN2A, BIRC5, SOX2, TP53
7MP:00030127.5VWF, CDH1, CDKN2A, KRT5, SOX2, TP53
8MP:00053867.3SOX2, TIMP2, MMP9, CTNNB1, CD44, CDKN2A
9MP:00053887.2TP53, CD44, CTNNB1, CDKN2A, CCND1, MMP2
10MP:00053907.2CD44, CTNNB1, CDKN2A, MMP2, MMP9, TERT
11MP:00053917.0H2AFX, CTNNB1, CD44, CDKN2A, CCND1, MMP2
12MP:00107717.0TP53, SOX2, KRT5, CDKN2A, CDH1, CD44
13MP:00028736.9CD44, CDH1, CCND1, MMP2, TIMP2, TP53
14MP:00053796.6TERT, CTNNB1, CD44, CDH1, CDKN2A, CCND1
15MP:00036316.4SOX2, CTNNB1, TERT, CCND1, MMP2, VWF
16MP:00053816.3SOX2, TERT, VWF, TP53, CCND1, CD44
17MP:00053896.2H2AFX, SOX2, TIMP1, TERT, TP53, CTNNB1
18MP:00053856.1CTNNB1, CCND1, CD44, CDH1, VWF, H2AFX
19MP:00053785.8CDH1, CTNNB1, CD44, CDKN2A, CCND1, MMP2
20MP:00053845.8CTNNB1, CD44, CDH1, CDKN2A, H2AFX, CCND1
21MP:00053975.7H2AFX, MMP2, MMP9, TIMP1, TIMP2, TP53
22MP:00020065.6CD44, TERT, H2AFX, TP53, TIMP1, MMP9
23MP:00053765.2CTNNB1, TERT, VWF, TP53, TIMP1, SOX2
24MP:00107684.9CCND1, BIRC5, KRT5, CDKN2A, TIMP1, CDH1
25MP:00053874.6CD44, CDH1, CDKN2A, TIMP1, SOX2, TP53

Publications for Vulvar Intraepithelial Neoplasia

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Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Efficacy of 5% imiquimod cream on vulvar intraepithelial neoplasia in Korea: pilot study. (25673934)
2015
2
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. (24399036)
2014
3
Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series. (25149547)
2014
4
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. (23032420)
2013
5
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. (23190170)
2013
6
Focused ultrasound therapy for vulvar intraepithelial neoplasia in a mice model. (23187305)
2013
7
Anti-HPV16 E2 protein T-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partners. (22590583)
2012
8
Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy. (22913259)
2012
9
Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series. (22207153)
2012
10
Optical coherence tomography in vulvar intraepithelial neoplasia. (23214182)
2012
11
Vulvar intraepithelial neoplasia (VIN 2/3): comparing clinical outcomes and evaluating risk factors for recurrence. (22867736)
2012
12
Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study. (22029821)
2011
13
The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment. (21873951)
2011
14
Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris. (20652114)
2009
15
A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian indigenous women. (18766449)
2009
16
Women's perception of the outcome of the surgical management of vulvar intraepithelial neoplasia. (19160655)
2008
17
Women's experiences with vulvar intraepithelial neoplasia. (19012714)
2008
18
A nonsurgical treatment for vulvar intraepithelial neoplasia. (18769666)
2008
19
Imiquimod 5% cream reduced lesion size in vulvar intraepithelial neoplasia. (18836111)
2008
20
Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia. (16633069)
2006
21
Concordance of gross surgical and final fixed margins in vulvar intraepithelial neoplasia 3 and vulvar cancer. (16967630)
2006
22
Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva. (16998595)
2006
23
Synchronous vulvar intraepithelial neoplasia (VIN) of warty type and cervical intraepithelial neoplasia (CIN): case report. (17183865)
2006
24
Re: "Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients". (16472846)
2006
25
Medical management of vulvar intraepithelial neoplasia. (16205189)
2005
26
Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. (16419625)
2005
27
Treatment of undifferentiated vulvar intraepithelial neoplasia with 5% imiquimod cream: a prospective study of 12 cases. (15492184)
2004
28
The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia, and vulvar lichen sclerosus as determined by microvessel density analysis. (12713988)
2003
29
Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests. (12521370)
2003
30
Loop electrosurgical excision procedure in vulvar intraepithelial neoplasia treatment. (17051029)
2002
31
CO2 laser surgery for vulvar intraepithelial neoplasia. Excisional, destructive and combined techniques. (12497680)
2002
32
Vulvar intraepithelial neoplasia treated with cavitational ultrasonic surgical aspiration. (11925129)
2002
33
Photodynamic therapy of vulvar intraepithelial neoplasia III using topically applied 5-aminolevulinic acid. (11136571)
2001
34
Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women. (10986677)
2000
35
A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. (10999722)
2000
36
Human papillomavirus DNA in multicentric vulvar intraepithelial neoplasia. (9475186)
1998
37
Angiogenesis in vulvar intraepithelial neoplasia. (9062159)
1997
38
Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus. (9166302)
1997
39
Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. (9277660)
1997
40
Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Italian Study Group on Vulvar Disease. (8887191)
1996
41
Vulvar intraepithelial neoplasia and vulvar cancer. (8784883)
1996
42
Biologic behavior of vulvar intraepithelial neoplasia. Histologic and clinical parameters. (8383203)
1993
43
Vulvar intraepithelial neoplasia. A clinicopathologic study of 60 cases. (2177508)
1990
44
Prospective randomized trial of topical alpha-interferon (alpha-interferon gels) for the treatment of vulvar intraepithelial neoplasia III. (2182407)
1990
45
Expression of the human papillomavirus type 16 genome in SK-v cells, a line derived from a vulvar intraepithelial neoplasia. (2157796)
1990
46
Unrecognized invasive carcinoma in vulvar intraepithelial neoplasia (VIN). (3410345)
1988
47
Laser surgery for vulvar intraepithelial neoplasia: principles and results. (3826173)
1987
48
Vulvar intraepithelial neoplasia: a report of two cases. (3744920)
1986
49
Vulvar intraepithelial neoplasia (severe atypia and carcinoma in situ). A clinicopathologic analysis of 41 cases. (6088029)
1984
50
Management of vulvar intraepithelial neoplasia by carbon dioxide laser. (6806733)
1982

Variations for Vulvar Intraepithelial Neoplasia

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Expression for genes affiliated with Vulvar Intraepithelial Neoplasia

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Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for genes affiliated with Vulvar Intraepithelial Neoplasia

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Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MMP1, CCND1, TIMP1
29.6TP53, KRT5, MMP1
39.6MMP2, BIRC5, CCND1
4
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway36
9.5TIMP1, TP53, MMP1
5
Show member pathways
9.4TP53, CDKN2A, CCND1
6
Show member pathways
9.4CDKN2A, CCND1, TP53
79.3MMP2, CD44, MMP9
89.2MMP9, MMP1, CD44, TIMP2
99.2H2AFX, TP53, CCND1
109.2MMP2, TIMP2, MMP9, TIMP1
119.2MMP2, MMP9, TIMP2, TIMP1
129.1MMP9, MMP2, MMP1, CCND1
139.1MMP9, BIRC5, TERT, TP53
14
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1BIRC5, CCND1, MMP9, TP53
15
Show member pathways
8.9MMP1, MMP9, MMP2, TIMP2, TIMP1
16
Show member pathways
DNA damage response36
8.9CCND1, TP53, CDKN2A, H2AFX
17
Show member pathways
8.9CCND1, H2AFX, TP53, CDKN2A
18
Show member pathways
Cell cycle36
8.8TP53, CDKN2A, CCND1, CDH1
198.7CDH1, CCND1, CTNNB1
208.6CDKN2A, CD44, CCND1, MMP9, TP53
21
Show member pathways
8.6TP53, TIMP1, VWF, CD44, MMP1
228.6CDH1, TP53, CTNNB1
238.6TP53, CCND1, CDKN2A, CTNNB1
24
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
8.5MMP9, MMP2, CCND1, CTNNB1
258.5CTNNB1, TP53, CCND1, CD44
268.5CTNNB1, CDKN2A, TP53, MMP2
27
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.5VWF, CCND1, CD44, CTNNB1
28
Show member pathways
8.4CDKN2A, H2AFX, CCND1, TP53, BIRC5, TERT
298.3MMP2, CD44, CTNNB1, CDH1
308.3CDKN2A, TERT, TP53, CCND1, CTNNB1
31
Show member pathways
8.3TIMP1, SOX2, CDH1, TIMP2, CTNNB1
328.3CTNNB1, BIRC5, CCND1, SOX2, CDH1
33
Show member pathways
Wnt Signaling Pathway NetPath36
8.3TP53, CCND1, CTNNB1, CDH1
348.3CDH1, CCND1, TP53, CTNNB1
358.0TP53, CDH1, BIRC5, CCND1, CTNNB1
36
Show member pathways
Signal transduction PTEN pathway59
8.0CTNNB1, TP53, CDH1, CCND1, BIRC5
37
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.0CD44, CDKN2A, CCND1, CTNNB1, TP53, SOX2
388.0CTNNB1, TP53, MMP1, CDH1, CCND1
39
Show member pathways
Metalloproteases in connective tissue degradation
7.9CD44, CDH1, MMP1, MMP2, MMP9, TIMP1
40
Show member pathways
7.9CDH1, TIMP2, MMP9, CD44, MMP2, MMP1
41
Show member pathways
7.8TP53, TIMP2, TIMP1, MMP9, MMP2, CD44
427.7CCND1, CD44, CTNNB1, TP53, MMP9, MMP2
43
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
7.7H2AFX, TP53, CCND1, CDH1, CTNNB1
447.7CCND1, MMP9, CTNNB1, CDH1, TERT, MMP2
45
Show member pathways
7.6MMP2, MMP9, TIMP1, TIMP2, TP53, CDKN2A
46
Show member pathways
7.2TIMP1, TIMP2, TP53, CCND1, CDKN2A, CDH1
477.0CCND1, MMP1, BIRC5, CDH1, TP53, CTNNB1
48
Show member pathways
Signaling Pathways in Glioblastoma36
6.9TP53, MMP9, MMP2, MMP1, CCND1, CTNNB1
496.7MMP9, MMP1, MMP2, TP53, CCND1, BIRC5

Compounds for genes affiliated with Vulvar Intraepithelial Neoplasia

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Compounds related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 245)
idCompoundScoreTop Affiliating Genes
1latanoprost44 1110.2TIMP2, MMP9, MMP1, MMP2, TIMP1
2(4-aminophenyl)mercuric acetate449.2TIMP1, MMP9, MMP2, MMP1, TIMP2
3methyl selenol448.9TIMP1, MMP9, MMP2, TIMP2
4p00001448.8CDH1, CDKN2A, TIMP2, CCND1, CD44, BIRC5
5crcs448.1CDH1, CDKN2A, BIRC5, CCND1, TP53, CTNNB1
6depsipeptide448.0CDH1, CDKN2A, CCND1, MMP2, TP53, H2AFX
7roscovitine448.0CTNNB1, BIRC5, CCND1, TP53, H2AFX, CDKN2A
812-o-tetradecanoylphorbol 13-acetate448.0TIMP1, MMP9, KRT5, CD44, TIMP2, CDH1
9doxycycline44 118.9CTNNB1, TIMP1, CDKN2A, MMP9, MMP2, MMP1
10methotrexate50 44 119.9CDH1, CDKN2A, BIRC5, CCND1, MMP1, MMP2
11celecoxib44 60 28 50 24 1112.8MMP2, CTNNB1, CDH1, BIRC5, MMP1, MMP9
12p002447.8CDH1, CD44, BIRC5, TIMP1, MMP9, TIMP2
13hyaluronic acid44 248.8CD44, VWF, TIMP2, TIMP1, MMP2, MMP1
14vitamin a44 24 119.7MMP1, CTNNB1, VWF, KRT5, BIRC5, MMP2
15etoposide44 50 60 1110.6CDH1, BIRC5, CD44, H2AFX, TP53, TERT
16tgf beta1447.5CDH1, CCND1, MMP1, MMP2, MMP9, CTNNB1
17adriamycin447.5CDKN2A, CTNNB1, CD44, CCND1, CDH1, BIRC5
185fluorouracil447.5TIMP2, BIRC5, TERT, TP53, CTNNB1, MMP2
19herbimycin a44 608.5TIMP1, MMP9, MMP1, MMP2, CDH1, CTNNB1
20lactate447.5TIMP2, TIMP1, VWF, MMP9, CD44, MMP2
21arsenite44 248.3CTNNB1, CDKN2A, BIRC5, CCND1, MMP1, MMP9
22pge2447.2MMP1, TIMP1, CD44, CDH1, MMP9, MMP2
23curcumin447.1CTNNB1, CDH1, BIRC5, CCND1, TP53, MMP1
24pd 98,059447.1CDH1, CTNNB1, BIRC5, CCND1, TERT, TIMP2
25h2o2447.1CTNNB1, MMP1, VWF, TP53, TIMP1, MMP2
26cytochalasin d44 608.0CTNNB1, CD44, VWF, TIMP1, MMP9, MMP2
27wortmannin446.9CTNNB1, BIRC5, CCND1, MMP2, MMP9, H2AFX
28sb 20358044 607.9TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
29cycloheximide446.9TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
30paclitaxel44 50 118.8TERT, TP53, TIMP2, TIMP1, MMP1, CCND1
31doxorubicin44 50 118.7TERT, H2AFX, TP53, MMP1, CCND1, BIRC5
32matrigel446.7VWF, TIMP2, TIMP1, MMP9, MMP2, MMP1
33cisplatin44 50 60 119.7H2AFX, CTNNB1, CD44, CDKN2A, BIRC5, CDH1
34butyrate446.6CCND1, MMP9, TIMP1, TIMP2, TP53, TERT
35genistein44 28 60 1 24 1111.6TERT, TIMP2, TIMP1, MMP9, MMP2, MMP1
36alanine446.5MMP9, CTNNB1, CD44, CDH1, CDKN2A, BIRC5
37phosphatidylinositol446.5CCND1, MMP9, CTNNB1, MMP2, TIMP1, CDH1
38progesterone44 28 60 24 1110.5CDH1, CD44, CTNNB1, CDKN2A, KRT5, TP53
39cysteine446.3MMP1, MMP2, CD44, MMP9, TIMP2, VWF
40arginine446.3CDKN2A, CTNNB1, CD44, CDH1, TIMP1, TP53
41egcg446.3CTNNB1, CDH1, CDKN2A, BIRC5, CCND1, MMP1
42testosterone44 60 24 119.2KRT5, CDKN2A, CDH1, CD44, CTNNB1, BIRC5
43ly294002446.0TP53, TIMP2, TIMP1, MMP9, MMP2, CCND1
44tyrosine445.9MMP9, CTNNB1, CD44, KRT5, BIRC5, CCND1
45n acetylcysteine445.5CTNNB1, H2AFX, VWF, TERT, CDH1, CDKN2A
46vegf445.4BIRC5, CDKN2A, CDH1, CD44, CTNNB1, CCND1
47estrogen445.2TERT, VWF, TP53, TIMP2, TIMP1, MMP9
48paraffin445.2MMP9, MMP2, MMP1, CCND1, BIRC5, KRT5
49retinoic acid44 246.0CDH1, CD44, CTNNB1, CDKN2A, KRT5, BIRC5
50serine444.7TERT, VWF, H2AFX, TP53, TIMP2, TIMP1

GO Terms for genes affiliated with Vulvar Intraepithelial Neoplasia

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Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00056579.4TP53, H2AFX
2catenin complexGO:00163429.1CTNNB1, CDH1
3proteinaceous extracellular matrixGO:00055789.1VWF, MMP9, MMP2, MMP1
4basolateral plasma membraneGO:00163238.4CDH1, CD44, CTNNB1
5extracellular regionGO:00055767.9CDH1, MMP1, MMP2, MMP9, TIMP1, TIMP2
6cytosolGO:00058297.9CTNNB1, CDKN2A, KRT5, BIRC5, CCND1, SOX2
7nucleoplasmGO:00056547.9TERT, H2AFX, TP53, CCND1, CDKN2A, CTNNB1
8cytoplasmGO:00057377.0TERT, TP53, SOX2, BIRC5, KRT5, CDKN2A

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:003157110.0TP53, CCND1
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00432819.9SOX2, CDH1
3positive regulation of cell cycle arrestGO:00711589.8CDKN2A, TP53
4replicative senescenceGO:00903999.8CDKN2A, TP53, TERT
5collagen catabolic processGO:00305749.8MMP1, MMP9, MMP2
6response to X-rayGO:00101659.7TP53, CCND1
7leukocyte migrationGO:00509009.7MMP9, MMP1, CD44
8cell cycle arrestGO:00070509.7TP53, CDKN2A, SOX2
9epithelial tube branching involved in lung morphogenesisGO:00604419.6SOX2, CTNNB1
10positive regulation of MAPK cascadeGO:00434109.5TIMP2, SOX2, CTNNB1
11positive regulation of neuroblast proliferationGO:00020529.5SOX2, CTNNB1
12response to cytokineGO:00340979.5CTNNB1, TIMP1, TIMP2
13cellular response to indole-3-methanolGO:00716819.4CTNNB1, CDH1
14regulation of protein localization to cell surfaceGO:020000089.4CTNNB1, CDH1
15male genitalia developmentGO:00305399.3CTNNB1, SOX2
16cellular response to DNA damage stimulusGO:00069749.2H2AFX, CCND1, TP53
17liver developmentGO:00018899.1CCND1, CTNNB1, VWF
18blood coagulationGO:00075969.0VWF, TP53, CD44, MMP1, TIMP1
19cell-cell adhesionGO:00163379.0CD44, CTNNB1, CDH1
20negative regulation of cell proliferationGO:00082858.9TP53, TIMP2, CDKN2A, CTNNB1
21negative regulation of apoptotic processGO:00430668.9TP53, CD44, TIMP1, BIRC5
22negative regulation of transcription, DNA-templatedGO:00458928.8CTNNB1, BIRC5, TP53, CDKN2A
23response to drugGO:00424938.8CDH1, TIMP2, CTNNB1, CCND1
24positive regulation of transcription, DNA-templatedGO:00458938.4CDH1, TP53, CDKN2A, CTNNB1, SOX2
25extracellular matrix disassemblyGO:00226178.3TIMP1, TIMP2, CD44, CDH1, MMP1, MMP2
26extracellular matrix organizationGO:00301987.8TIMP1, VWF, MMP9, MMP2, MMP1, CDH1

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:00973719.9CDKN2A, TP53
2metalloendopeptidase inhibitor activityGO:00081919.9TIMP1, TIMP2
3chaperone bindingGO:00510879.5TP53, VWF, BIRC5
4metalloendopeptidase activityGO:00042229.4MMP2, MMP1, MMP9
5collagen bindingGO:00055189.4VWF, MMP9, CD44
6protease bindingGO:00020209.4VWF, TP53, TIMP1
7transcription regulatory region DNA bindingGO:00442129.0TP53, CTNNB1, SOX2
8protein phosphatase bindingGO:00199038.8CDH1, TP53, CTNNB1
9transcription factor bindingGO:00081348.7TP53, CCND1, CDKN2A, CTNNB1
10protein kinase bindingGO:00199018.6TP53, CCND1, CDKN2A, CTNNB1
11identical protein bindingGO:00428028.6TP53, MMP9, BIRC5, VWF
12enzyme bindingGO:00198998.4CCND1, BIRC5, TP53, H2AFX, CTNNB1
13protein bindingGO:00055154.6CCND1, TERT, MMP2, MMP9, SOX2, TIMP1

Sources for Vulvar Intraepithelial Neoplasia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet