MCID: VLV044
MIFTS: 40

Vulvar Intraepithelial Neoplasia

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

MalaCards integrated aliases for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 55
Vulval Intraepithelial Neoplasia 69
Vulvar Intraepithelial Tumor 55

Classifications:



External Ids:

Orphanet 55 ORPHA137583
UMLS via Orphanet 70 C0346210
ICD10 via Orphanet 33 D07.1
UMLS 69 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

MalaCards based summary : Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to vulva cancer and squamous cell carcinoma, and has symptoms including macule and pruritus. An important gene associated with Vulvar Intraepithelial Neoplasia is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Pathways in cancer and Immune response IL-23 signaling pathway. The drugs Imiquimod and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and cervix.

Wikipedia : 72 Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that... more...

Related Diseases for Vulvar Intraepithelial Neoplasia

Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 vulva cancer 32.5 KRT7 TP53
2 squamous cell carcinoma 30.6 KRT7 MMP2 TP53
3 bowen's disease 30.1 KRT10 KRT7
4 lichen planus 30.1 KRT10 TP53
5 papilloma 29.9 KRT10 KRT7 TP53
6 cervicitis 10.4
7 lichen sclerosus 10.3
8 bladder transitional cell papilloma 10.3 BIRC5 TP53
9 cervical carcinosarcoma 10.3 BIRC5 TP53
10 keratocystic odontogenic tumor 10.3 BIRC5 TP53
11 skin squamous cell carcinoma 10.3 BIRC5 TP53
12 breast metaplastic carcinoma 10.2 KRT10 TP53
13 pinguecula 10.2 KRT10 TP53
14 keratoacanthoma 10.2 KRT10 TP53
15 malignant spiradenoma 10.2 KRT7 TP53
16 grade iii astrocytoma 10.2 MMP2 TP53
17 female reproductive endometrioid cancer 10.2 KRT7 TP53
18 eccrine sweat gland neoplasm 10.2 KRT7 TP53
19 bladder carcinoma in situ 10.2 KRT7 TP53
20 actinic keratosis 10.2 MMP2 TP53
21 papillary serous adenocarcinoma 10.2 KRT7 TP53
22 nasal cavity adenocarcinoma 10.2 KRT7 TP53
23 glycogen-rich clear cell breast carcinoma 10.2 KRT7 TP53
24 pleomorphic carcinoma 10.2 KRT7 TP53
25 biliary papillomatosis 10.2 KRT7 TP53
26 tongue squamous cell carcinoma 10.2 MMP2 TP53
27 spiradenoma 10.2 KRT7 TP53
28 endocervical adenocarcinoma 10.2 KRT7 TP53
29 tongue cancer 10.2 MMP2 TP53
30 ovary adenocarcinoma 10.2 KRT7 TP53
31 mixed cell type cancer 10.2 KRT7 TP53
32 epithelial-myoepithelial carcinoma 10.2 KRT7 TP53
33 vaginitis 10.2
34 necrotizing sialometaplasia 10.2 KRT7 TP53
35 cystic teratoma 10.2 KRT7 TP53
36 basaloid squamous cell carcinoma 10.2 KRT7 TP53
37 granulosa cell tumor of the ovary 10.2 KRT7 TP53
38 biliary tract neoplasm 10.2 KRT7 TP53
39 inverted papilloma 10.2 KRT7 TP53
40 hidradenocarcinoma 10.2 KRT7 TP53
41 pseudomyxoma peritonei 10.2 KRT7 TP53
42 signet ring cell adenocarcinoma 10.2 KRT7 TP53
43 acinar cell carcinoma 10.2 KRT7 TP53
44 skin melanoma 10.2 MMP2 TP53
45 mucinous adenocarcinoma 10.2 KRT7 TP53
46 bile duct adenocarcinoma 10.2 KRT7 TP53
47 gastrointestinal system benign neoplasm 10.2 KRT7 TP53
48 germ cell and embryonal cancer 10.2 KRT7 TP53
49 pancreatic ductal carcinoma 10.1 KRT7 TP53
50 ovarian clear cell carcinoma 10.1 KRT7 TP53

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to Vulvar Intraepithelial Neoplasia

Symptoms & Phenotypes for Vulvar Intraepithelial Neoplasia

UMLS symptoms related to Vulvar Intraepithelial Neoplasia:


macule, pruritus

Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

Drugs for Vulvar Intraepithelial Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
2
Aluminum hydroxide Approved, Investigational Phase 3 21645-51-2
3
Aluminum sulfate Approved Phase 3 10043-01-3
4 interferons Phase 2, Phase 3
5 Adjuvants, Immunologic Phase 2, Phase 3
6 Vaccines Phase 3,Phase 2,Phase 1
7 Interferon Inducers Phase 2, Phase 3
8 Anesthetics Phase 3
9
Zinc Approved, Investigational Phase 2 7440-66-6 32051 23994
10
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 50-18-0, 6055-19-2 2907
11
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
12
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
13 Analgesics Phase 2
14 Alkylating Agents Phase 2,Phase 1
15 Gastrointestinal Agents Phase 2
16 Tocolytic Agents Phase 2
17 Cyclooxygenase Inhibitors Phase 2
18 Analgesics, Non-Narcotic Phase 2
19 Vitamins Phase 2
20 Antacids Phase 2
21 Peripheral Nervous System Agents Phase 2
22 Immunosuppressive Agents Phase 2,Phase 1
23 Anti-Inflammatory Agents Phase 2
24 Anti-Inflammatory Agents, Non-Steroidal Phase 2
25 Anti-Ulcer Agents Phase 2
26 Proton pump inhibitors Phase 2
27 Antirheumatic Agents Phase 2,Phase 1
28
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
29
Aldesleukin Approved Phase 1 110942-02-4, 85898-30-2
30
Pembrolizumab Approved Phase 1 1374853-91-4
31 Antibodies, Monoclonal Phase 1
32 Anti-HIV Agents Phase 1
33 Anti-Infective Agents Phase 1
34 Immunoglobulins Phase 1
35 Anti-Retroviral Agents Phase 1
36 Antibodies Phase 1
37 Antiviral Agents Phase 1

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
2 A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia Completed NCT00394758 Phase 3
3 ITIC (Imiquimod Therapy in Cervical Intraepithelial Neoplasia)-Trial Completed NCT00941252 Phase 2, Phase 3 Topical imiquimod therapy
4 A Bridging Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Completed NCT02562508 Phase 3
5 Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia Recruiting NCT01861535 Phase 3 Imiquimod
6 Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent(Type 16/18 )Vaccine Active, not recruiting NCT01735006 Phase 3
7 Imiquimod Treatment of CIN Lesions Terminated NCT02329171 Phase 3 Imiquimod
8 Immunevasion of Human Papillomavirus (HPV) in Vulvar Intraepithelial Neoplasia 2/3 and Anogenital Warts and Efficiency and Mechanisms of Imiquimod Treatment Completed NCT00941811 Phase 2 Imiquimod
9 Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With uVIN Completed NCT02596074 Phase 2 Omiganan (CLS001) topical gel;Vehicle topical gel
10 The Impact of the "WOMAN-PRO II Program" on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence Completed NCT01986725 Phase 2
11 Dose-Ranging Study of Quadrivalent Human Papillomavirus (HPV) (Types 6,11,16,18) L1 Virus-Like Particle (VLP) Vaccine (V501-007)(COMPLETED) Completed NCT00365716 Phase 2
12 IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3 Recruiting NCT03267680 Phase 2 Cyclophosphamide;Indomethacin;Omeprazole
13 VGX-3100 Followed by Electroporation Alone or in Combination With Imiquimod for the Treatment of Human Papilloma Virus HPV-16 and/or HPV-18 Related Vulvar High Grade Squamous Intraepithelial Lesion (HSIL) (Also Referred as: VIN, VIN 2 or VIN 3, Vulvar Dys Recruiting NCT03180684 Phase 2 Imiquimod 5% cream
14 E7 TCR T Cells With or Without PD-1 Blockade for Human Papillomavirus-Associated Cancers Recruiting NCT02858310 Phase 1 pembrolizumab;aldesleukin;fludarabine;cyclophosphamide
15 A New Patient Reported Outcome Instrument to Assess Symptom Experience in Women With Vulvar Neoplasms (WOMAN-PRO) Unknown status NCT01300663
16 SR-T100 Gel Efficacy & Safety Study for Vulva Pre-cancerous Lesions & Cutaneous Condyloma Completed NCT01676792 Early Phase 1 SR-T100 gel with 2.3% of SM in Solanum undatum plant extract
17 Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia Recruiting NCT02875561
18 Prevalence of Anal Dysplasia and Anal Cancer in Women With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021
19 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Recruiting NCT02735109
20 Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Active, not recruiting NCT03206255
21 Evaluation of Long-term HPV Vaccine Efficacy Enrolling by invitation NCT01393470
22 Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Not yet recruiting NCT03061435
23 OCT-AF Imaging of Pre-cancers of Vulva and Cervix Not yet recruiting NCT03285841
24 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975
25 Colposcopy and High Resolution Anoscopy in Screening For Anal Dysplasia in Patients With Cervical, Vaginal, or Vulvar Dysplasia or Cancer Withdrawn NCT01313104

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

Anatomical Context for Vulvar Intraepithelial Neoplasia

MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

38
Skin, T Cells, Cervix, Testes, Endothelial, Nk Cells, Lung

Publications for Vulvar Intraepithelial Neoplasia

Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50) (show all 239)
# Title Authors Year
1
The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia. ( 29393881 )
2018
2
Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model. ( 29315730 )
2018
3
Vulvar intraepithelial neoplasia: Risk factors for recurrence. ( 29126556 )
2018
4
Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications. ( 29434343 )
2018
5
Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia. ( 28795241 )
2017
6
HPV-independent Differentiated Vulvar Intraepithelial Neoplasia (dVIN) is Associated With an Aggressive Clinical Course. ( 28319571 )
2017
7
Dermoscopic features of pigmented vulvar intraepithelial neoplasia. ( 28940726 )
2017
8
Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3). ( 28954490 )
2017
9
Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma. ( 29299981 )
2017
10
Committee Opinion No. 675: Management of Vulvar Intraepithelial Neoplasia: Correction. ( 28092302 )
2017
11
Yield of Cytology Surveillance After High-Grade Vulvar Intraepithelial Neoplasia or Cancer. ( 28644191 )
2017
12
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia. ( 28451790 )
2017
13
Type-specific HPV infection correlates with risk of recurrence of vulvar intraepithelial neoplasia usual type. ( 28006842 )
2016
14
The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges. ( 26974999 )
2016
15
Distinguishing Erosive Lichen Planus From Differentiated Vulvar Intraepithelial Neoplasia. ( 26796658 )
2016
16
Vulvar intraepithelial neoplasia: clinical presentation, management and outcomes in women infected with HIV. ( 26959352 )
2016
17
Vulvar intraepithelial neoplasia grade 3 associated with BehAset's disease. ( 26983442 )
2016
18
Dermoscopic findings of vulvar intraepithelial neoplasia (VIN): a series of 4 cases. ( 27291788 )
2016
19
Extra-Genital Bowen's Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia. ( 27298533 )
2016
20
Usual-type vulvar intraepithelial neoplasia: report of a case and its dermoscopic features. ( 27419656 )
2016
21
Committee Opinion No. 675 Summary: Management of Vulvar Intraepithelial Neoplasia. ( 27661648 )
2016
22
Differentiated Vulvar Intraepithelial Neoplasia: What Criteria Do We Use in Practice? ( 27105329 )
2016
23
Medical and Surgical Treatments for Usual-Type Vulvar Intraepithelial Neoplasia. ( 27490514 )
2016
24
MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia. ( 27399691 )
2016
25
Committee Opinion No.675: Management of Vulvar Intraepithelial Neoplasia. ( 27661656 )
2016
26
Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia. ( 27513074 )
2016
27
Vulvar and Vaginal Cancer, Vulvar Intraepithelial Neoplasia 3 and Vaginal Intraepithelial Neoplasia 3: Experience of a Referral Institute. ( 27430086 )
2016
28
No viral association found in a set of differentiated vulvar intraepithelial neoplasia cases by human papillomavirus and pan-viral microarray testing. ( 25894343 )
2015
29
Vulvar Intraepithelial Neoplasia (VIN) and Condylomata. ( 26133495 )
2015
30
Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: A review. ( 26335596 )
2015
31
Efficacy of 5% imiquimod cream on vulvar intraepithelial neoplasia in Korea: pilot study. ( 25673934 )
2015
32
LASER VAPORIZATION IN VULVAR INTRAEPITHELIAL NEOPLASIA (VIN), VAGINAL INTRAEPITHELIAL NEOPLASIA (VAIN) AND CONDYLOMATA ACUMINATA: IGCS-0093 Vulvar and Vaginal Cancer. ( 25955950 )
2015
33
Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series. ( 25149547 )
2014
34
Surgical treatment of usual type vulvar intraepithelial neoplasia: a study at three academic hospitals. ( 24534242 )
2014
35
Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival. ( 25220367 )
2014
36
Vulvar intraepithelial neoplasia. ( 25106700 )
2014
37
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. ( 24399036 )
2014
38
Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy. ( 24415578 )
2014
39
Fascin and cyclin D1 immunoreactivity in non-neoplastic vulvar squamous epithelium, vulvar intraepithelial neoplasia and invasive squamous carcinoma: correlation with Ki67 and p16 protein expression. ( 24218024 )
2013
40
Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: independent lesions due to different HPV types occurring in immunocompromised patients. ( 23026935 )
2013
41
Interobserver variability and the effect of education in the histopathological diagnosis of differentiated vulvar intraepithelial neoplasia. ( 23370772 )
2013
42
Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia. ( 23765247 )
2013
43
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. ( 23190170 )
2013
44
Aberrant staining patterns of E-cadherin and I^-catenin: a potential diagnostic value for distinguishing vulvar intraepithelial neoplasia from non-neoplastic vulvar lesions. ( 23826417 )
2013
45
Clinical characteristics associated with development of recurrence and progression in usual-type vulvar intraepithelial neoplasia. ( 24257562 )
2013
46
Treatment of vulvar intraepithelial neoplasia with topical 5% imiquimod cream. ( 23219095 )
2013
47
Immunohistochemical expression of SOX2 in vulvar intraepithelial neoplasia and squamous cell carcinoma. ( 23518916 )
2013
48
Treatment of vulvar intraepithelial neoplasia with CO(2) laser vaporization and excision surgery. ( 23609594 )
2013
49
Focused ultrasound therapy for vulvar intraepithelial neoplasia in a mice model. ( 23187305 )
2013
50
Quality of life and female sexual function after skinning vulvectomy with split-thickness skin graft in women with vulvar intraepithelial neoplasia or vulvar Paget disease. ( 24090498 )
2013

Variations for Vulvar Intraepithelial Neoplasia

Expression for Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for Vulvar Intraepithelial Neoplasia

GO Terms for Vulvar Intraepithelial Neoplasia

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 BIRC5 TP53

Sources for Vulvar Intraepithelial Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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