MCID: VLV044
MIFTS: 56

Vulvar Intraepithelial Neoplasia malady

Reproductive diseases, Cancer diseases, Rare diseases categories
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Summaries for Vulvar Intraepithelial Neoplasia

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Wikipedia:65 The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin... more...

MalaCards based summary: Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to cervical intraepithelial neoplasia and papilloma. An important gene associated with Vulvar Intraepithelial Neoplasia is KRT5 (keratin 5), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Glucocorticoid receptor regulatory network. The compounds latanoprost and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are taste/olfaction and pigmentation.

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Vulvar Intraepithelial Neoplasia, Aliases & Descriptions:

Name: Vulvar Intraepithelial Neoplasia 48
Vulval Intraepithelial Neoplasia 62
 
Vulvar Intraepithelial Tumor 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

UMLS via Orphanet63 C0346210

Related Diseases for Vulvar Intraepithelial Neoplasia

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Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia31.1CDKN2A, BIRC5, TERT
2papilloma31.0CDKN2A, KRT5, TP53
3melanoma28.0CTNNB1, CD44, CDH1, CDKN2A, BIRC5, CCND1
4cervicitis10.8
5lichen sclerosus10.7
6meningioma10.6TERT
7vulvovaginitis10.5
8blindness10.5
9actinic keratosis10.4TP53
10turcot syndrome10.4CTNNB1
11arthropathy10.4MMP1, TIMP1
12oral submucous fibrosis10.4MMP1, TIMP1
13oral lichen planus10.4MMP1, TIMP2
14pulpitis10.4MMP1, TIMP1
15craniopharyngioma10.4CTNNB1
16fibromatosis10.4CTNNB1, TIMP2
17benign meningioma10.4BIRC5, TERT
18fibromatosis, gingival10.4MMP1, MMP2
19thoracic aortic aneurysm10.3MMP1, MMP2
20gingival overgrowth10.3MMP1, TIMP1
21synovitis10.3MMP1, TIMP1, TIMP2
22carotid stenosis10.3MMP1, MMP9
23multiple myeloma10.3CD44, CCND1
24middle ear cholesteatoma10.3MMP1, MMP9
25acne10.3
26systemic lupus erythematosus10.3
27amyloidosis10.3
28herpes simplex10.3
29lupus erythematosus10.3
30vulva cancer10.3
31vulvar disease10.3
32t-lymphocytopenia10.3
33trichofolliculoma10.3
34endotheliitis10.3
35lymphangioleiomyomatosis10.3MMP1, MMP2
36benign mesothelioma10.3KRT5, TP53
37gallbladder adenoma10.3CTNNB1, CDKN2A
38oropharyngeal cancer, adult10.3CDKN2A, TP53
39periodontitis10.3MMP9
40li-fraumeni syndrome10.3CDKN2A, TP53
41pulmonary emphysema10.2MMP1, MMP9, TIMP2
42relapsing-remitting multiple sclerosis10.2MMP9, TIMP1
43gingivitis10.2MMP1, TIMP1
44malignant peripheral nerve sheath tumor10.2CD44, CDKN2A, TERT
45keratoconus10.2MMP1, MMP2, TIMP1
46periodontal disease10.2MMP1, MMP2, TIMP1
47glomerulosclerosis10.2MMP2, TIMP1, TIMP2
48chronic obstructive pulmonary disease10.2MMP9, TIMP1
49proliferative diabetic retinopathy10.2MMP9, TIMP1, TIMP2
50kawasaki disease10.2MMP9, TIMP1

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to vulvar intraepithelial neoplasia

Symptoms for Vulvar Intraepithelial Neoplasia

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Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

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Drug clinical trials:

Search ClinicalTrials for Vulvar Intraepithelial Neoplasia

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

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Anatomical Context for Vulvar Intraepithelial Neoplasia

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MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

32
Skin, T cells, Testes, Lung, Endothelial

Animal Models for Vulvar Intraepithelial Neoplasia or affiliated genes

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MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2CTNNB1, SOX2, TERT
2MP:00011868.6CTNNB1, CDKN2A, SOX2, TP53
3MP:00053718.2TP53, MMP9, KRT5, CD44, CTNNB1
4MP:00053828.1TP53, SOX2, MMP2, CCND1, KRT5, CTNNB1
5MP:00053697.7TP53, SOX2, MMP9, MMP2, CDKN2A, CD44
6MP:00053807.5TP53, SOX2, BIRC5, CDKN2A, CDH1, CTNNB1
7MP:00030127.5VWF, TP53, SOX2, KRT5, CDKN2A, CDH1
8MP:00053867.3TP53, TIMP2, SOX2, MMP9, CCND1, KRT5
9MP:00053887.2TP53, TIMP1, SOX2, MMP9, MMP2, CCND1
10MP:00053907.2TERT, TP53, SOX2, MMP9, MMP2, CCND1
11MP:00053917.0H2AFX, TP53, SOX2, MMP9, MMP2, CCND1
12MP:00107717.0TP53, SOX2, MMP9, CCND1, KRT5, CDKN2A
13MP:00028736.9TERT, TP53, TIMP2, SOX2, MMP2, CCND1
14MP:00053796.6TERT, H2AFX, TP53, TIMP1, SOX2, CCND1
15MP:00036316.4TIMP2, TP53, VWF, TERT, SOX2, MMP9
16MP:00053816.3TERT, VWF, TP53, SOX2, MMP9, CCND1
17MP:00053896.2TERT, H2AFX, TP53, TIMP1, SOX2, MMP9
18MP:00053856.1VWF, H2AFX, TP53, TIMP1, MMP9, MMP2
19MP:00053785.8SOX2, TIMP1, TP53, H2AFX, TERT, MMP9
20MP:00053845.8SOX2, TP53, H2AFX, VWF, TERT, MMP9
21MP:00053975.7TIMP2, TP53, H2AFX, VWF, TERT, TIMP1
22MP:00020065.6CTNNB1, CD44, CDH1, CDKN2A, CCND1, MMP1
23MP:00053765.2SOX2, TIMP1, TIMP2, TP53, VWF, TERT
24MP:00107684.9SOX2, TIMP1, TP53, H2AFX, VWF, TERT
25MP:00053874.6CTNNB1, TERT, VWF, CD44, CDH1, CDKN2A

Publications for Vulvar Intraepithelial Neoplasia

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Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. (24399036)
2014
2
Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series. (25149547)
2014
3
Immunohistochemical expression of SOX2 in vulvar intraepithelial neoplasia and squamous cell carcinoma. (23518916)
2013
4
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. (23032420)
2013
5
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. (23190170)
2013
6
Focused ultrasound therapy for vulvar intraepithelial neoplasia in a mice model. (23187305)
2013
7
Anti-HPV16 E2 protein T-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partners. (22590583)
2012
8
Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy. (22913259)
2012
9
Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series. (22207153)
2012
10
Optical coherence tomography in vulvar intraepithelial neoplasia. (23214182)
2012
11
Vulvar intraepithelial neoplasia (VIN 2/3): comparing clinical outcomes and evaluating risk factors for recurrence. (22867736)
2012
12
Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study. (22029821)
2011
13
The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment. (21873951)
2011
14
Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris. (20652114)
2009
15
A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian indigenous women. (18766449)
2009
16
Women's perception of the outcome of the surgical management of vulvar intraepithelial neoplasia. (19160655)
2008
17
Women's experiences with vulvar intraepithelial neoplasia. (19012714)
2008
18
A nonsurgical treatment for vulvar intraepithelial neoplasia. (18769666)
2008
19
Imiquimod 5% cream reduced lesion size in vulvar intraepithelial neoplasia. (18836111)
2008
20
Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia. (16633069)
2006
21
Concordance of gross surgical and final fixed margins in vulvar intraepithelial neoplasia 3 and vulvar cancer. (16967630)
2006
22
Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva. (16998595)
2006
23
Synchronous vulvar intraepithelial neoplasia (VIN) of warty type and cervical intraepithelial neoplasia (CIN): case report. (17183865)
2006
24
Re: "Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients". (16472846)
2006
25
Medical management of vulvar intraepithelial neoplasia. (16205189)
2005
26
Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. (16419625)
2005
27
Treatment of undifferentiated vulvar intraepithelial neoplasia with 5% imiquimod cream: a prospective study of 12 cases. (15492184)
2004
28
The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia, and vulvar lichen sclerosus as determined by microvessel density analysis. (12713988)
2003
29
Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests. (12521370)
2003
30
Loop electrosurgical excision procedure in vulvar intraepithelial neoplasia treatment. (17051029)
2002
31
Vulvar intraepithelial neoplasia treated with cavitational ultrasonic surgical aspiration. (11925129)
2002
32
Photodynamic therapy of vulvar intraepithelial neoplasia III using topically applied 5-aminolevulinic acid. (11136571)
2001
33
Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women. (10986677)
2000
34
A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. (10999722)
2000
35
Human papillomavirus DNA in multicentric vulvar intraepithelial neoplasia. (9475186)
1998
36
Differentiating vulvar intraepithelial neoplasia from nonneoplastic epithelial disorders. The toluidine blue test. (9749417)
1998
37
Angiogenesis in vulvar intraepithelial neoplasia. (9062159)
1997
38
Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus. (9166302)
1997
39
Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. (9277660)
1997
40
Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Italian Study Group on Vulvar Disease. (8887191)
1996
41
Vulvar intraepithelial neoplasia and vulvar cancer. (8784883)
1996
42
Biologic behavior of vulvar intraepithelial neoplasia. Histologic and clinical parameters. (8383203)
1993
43
Vulvar intraepithelial neoplasia. A clinicopathologic study of 60 cases. (2177508)
1990
44
Prospective randomized trial of topical alpha-interferon (alpha-interferon gels) for the treatment of vulvar intraepithelial neoplasia III. (2182407)
1990
45
Expression of the human papillomavirus type 16 genome in SK-v cells, a line derived from a vulvar intraepithelial neoplasia. (2157796)
1990
46
Unrecognized invasive carcinoma in vulvar intraepithelial neoplasia (VIN). (3410345)
1988
47
Laser surgery for vulvar intraepithelial neoplasia: principles and results. (3826173)
1987
48
Vulvar intraepithelial neoplasia: a report of two cases. (3744920)
1986
49
Vulvar intraepithelial neoplasia (severe atypia and carcinoma in situ). A clinicopathologic analysis of 41 cases. (6088029)
1984
50
Management of vulvar intraepithelial neoplasia by carbon dioxide laser. (6806733)
1982

Variations for Vulvar Intraepithelial Neoplasia

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Expression for genes affiliated with Vulvar Intraepithelial Neoplasia

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Expression patterns in normal tissues for genes affiliated with Vulvar Intraepithelial Neoplasia

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Pathways for genes affiliated with Vulvar Intraepithelial Neoplasia

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Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCND1, MMP1, TIMP1
29.6TP53, MMP1, KRT5
39.6BIRC5, CCND1, MMP2
4
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.5MMP1, TIMP1, TP53
5
Show member pathways
9.4TP53, CCND1, CDKN2A
6
Show member pathways
9.4CDKN2A, CCND1, TP53
79.3MMP9, MMP2, CD44
89.2TIMP2, MMP9, MMP1, CD44
99.2CDH1, SOX2, TP53
109.2H2AFX, TP53, CCND1
119.2TIMP2, TIMP1, MMP9, MMP2
129.2TIMP2, TIMP1, MMP9, MMP2
139.1CCND1, MMP1, MMP2, MMP9
149.1TERT, TP53, MMP9, BIRC5
15
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1TP53, MMP9, CCND1, BIRC5
16
Show member pathways
8.9TIMP2, TIMP1, MMP9, MMP2, MMP1
17
Show member pathways
DNA damage response37
8.9H2AFX, TP53, CCND1, CDKN2A
18
Show member pathways
8.9H2AFX, TP53, CCND1, CDKN2A
19
Show member pathways
Cell cycle37
8.8CDH1, CDKN2A, CCND1, TP53
208.7CTNNB1, CDH1, CCND1
218.6CD44, CDKN2A, CCND1, MMP9, TP53
22
Show member pathways
8.6CD44, MMP1, TIMP1, TP53, VWF
238.6CTNNB1, CDH1, TP53
248.6TP53, CCND1, CDKN2A, CTNNB1
25
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5MMP9, MMP2, CCND1, CTNNB1
268.5TP53, CCND1, CD44, CTNNB1
278.5CTNNB1, CDKN2A, MMP2, TP53
28
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.5VWF, CCND1, CD44, CTNNB1
29
Show member pathways
8.4TERT, H2AFX, TP53, CCND1, BIRC5, CDKN2A
308.3CTNNB1, CD44, CDH1, MMP2
318.3TERT, TP53, CCND1, CDKN2A, CTNNB1
32
Show member pathways
8.3TIMP2, TIMP1, SOX2, CDH1, CTNNB1
338.3SOX2, CCND1, BIRC5, CDH1, CTNNB1
348.3TP53, CCND1, CDH1, CTNNB1
35
Show member pathways
Wnt Signaling Pathway NetPath37
8.3CTNNB1, CDH1, CCND1, TP53
36
Show member pathways
Signal transduction PTEN pathway60
8.0TP53, CCND1, BIRC5, CDH1, CTNNB1
378.0TP53, CCND1, BIRC5, CDH1, CTNNB1
38
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.0TP53, SOX2, CCND1, CDKN2A, CD44, CTNNB1
398.0TP53, MMP1, CCND1, CDH1, CTNNB1
40
Show member pathways
7.9TIMP2, TIMP1, MMP9, MMP2, MMP1, CDH1
41
Show member pathways
7.9TIMP2, TIMP1, MMP9, MMP2, MMP1, CDH1
42
Show member pathways
7.8TERT, TP53, TIMP2, TIMP1, MMP9, MMP2
437.7TP53, MMP9, MMP2, CCND1, CD44, CTNNB1
44
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
7.7H2AFX, TP53, CCND1, CDH1, CTNNB1
457.7TERT, MMP9, MMP2, CCND1, CDH1, CTNNB1
46
Show member pathways
7.6TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
47
Show member pathways
7.2TP53, TIMP2, TIMP1, SOX2, CCND1, CDKN2A
487.0CTNNB1, TP53, MMP9, MMP2, MMP1, CCND1
49
Show member pathways
Signaling Pathways in Glioblastoma37
6.9TP53, MMP9, MMP2, MMP1, CCND1, CDKN2A
506.7TP53, MMP9, MMP2, MMP1, CCND1, BIRC5

Compounds for genes affiliated with Vulvar Intraepithelial Neoplasia

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Compounds related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 245)
idCompoundScoreTop Affiliating Genes
1latanoprost44 1110.2TIMP2, MMP9, MMP1, MMP2, TIMP1
2(4-aminophenyl)mercuric acetate449.2TIMP1, MMP9, MMP2, MMP1, TIMP2
3methyl selenol448.9TIMP1, MMP9, MMP2, TIMP2
4p00001448.8CDH1, CDKN2A, TIMP2, CCND1, CD44, BIRC5
5crcs448.1CDH1, CDKN2A, BIRC5, CCND1, TP53, CTNNB1
6depsipeptide448.0CDH1, CDKN2A, CCND1, MMP2, TP53, H2AFX
7roscovitine448.0CTNNB1, BIRC5, CCND1, TP53, H2AFX, CDKN2A
812-o-tetradecanoylphorbol 13-acetate448.0TIMP1, MMP9, KRT5, CD44, TIMP2, CDH1
9doxycycline44 118.9CTNNB1, TIMP1, CDKN2A, MMP9, MMP2, MMP1
10methotrexate50 44 119.9CDH1, CDKN2A, BIRC5, CCND1, MMP1, MMP2
11celecoxib44 61 28 50 24 1112.8MMP2, CTNNB1, CDH1, BIRC5, MMP1, MMP9
12p002447.8CDH1, CD44, BIRC5, TIMP1, MMP9, TIMP2
13hyaluronic acid44 248.8CD44, VWF, TIMP2, TIMP1, MMP2, MMP1
14vitamin a44 24 119.7MMP1, CTNNB1, VWF, KRT5, BIRC5, MMP2
15etoposide44 50 61 1110.6CDH1, BIRC5, CD44, H2AFX, TP53, TERT
16tgf beta1447.5CDH1, CCND1, MMP1, MMP2, MMP9, CTNNB1
17adriamycin447.5CDKN2A, CTNNB1, CD44, CCND1, CDH1, BIRC5
185fluorouracil447.5TIMP2, BIRC5, TERT, TP53, CTNNB1, MMP2
19herbimycin a44 618.5TIMP1, MMP9, MMP1, MMP2, CDH1, CTNNB1
20lactate447.5TIMP2, TIMP1, VWF, MMP9, CD44, MMP2
21arsenite44 248.3CTNNB1, CDKN2A, BIRC5, CCND1, MMP1, MMP9
22pge2447.2MMP1, TIMP1, CD44, CDH1, MMP9, MMP2
23curcumin447.1CTNNB1, CDH1, BIRC5, CCND1, TP53, MMP1
24pd 98,059447.1CDH1, CTNNB1, BIRC5, CCND1, TERT, TIMP2
25h2o2447.1CTNNB1, MMP1, VWF, TP53, TIMP1, MMP2
26cytochalasin d44 618.0CTNNB1, CD44, VWF, TIMP1, MMP9, MMP2
27wortmannin446.9CTNNB1, BIRC5, CCND1, MMP2, MMP9, H2AFX
28sb 20358044 617.9TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
29cycloheximide446.9TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
30paclitaxel44 50 118.8TERT, TP53, TIMP2, TIMP1, MMP1, CCND1
31doxorubicin44 50 118.7TERT, H2AFX, TP53, MMP1, CCND1, BIRC5
32matrigel446.7VWF, TIMP2, TIMP1, MMP9, MMP2, MMP1
33cisplatin44 50 61 119.7H2AFX, CTNNB1, CD44, CDKN2A, BIRC5, CDH1
34butyrate446.6CCND1, MMP9, TIMP1, TIMP2, TP53, TERT
35genistein44 28 61 2 24 1111.6TERT, TIMP2, TIMP1, MMP9, MMP2, MMP1
36alanine446.5MMP9, CTNNB1, CD44, CDH1, CDKN2A, BIRC5
37phosphatidylinositol446.5CCND1, MMP9, CTNNB1, MMP2, TIMP1, CDH1
38progesterone44 28 61 24 1110.5CDH1, CD44, CTNNB1, CDKN2A, KRT5, TP53
39cysteine446.3MMP1, MMP2, CD44, MMP9, TIMP2, VWF
40arginine446.3CDKN2A, CTNNB1, CD44, CDH1, TIMP1, TP53
41egcg446.3CTNNB1, CDH1, CDKN2A, BIRC5, CCND1, MMP1
42testosterone44 61 24 119.2KRT5, CDKN2A, CDH1, CD44, CTNNB1, BIRC5
43ly294002446.0TP53, TIMP2, TIMP1, MMP9, MMP2, CCND1
44tyrosine445.9MMP9, CTNNB1, CD44, KRT5, BIRC5, CCND1
45n acetylcysteine445.5CTNNB1, H2AFX, VWF, TERT, CDH1, CDKN2A
46vegf445.4BIRC5, CDKN2A, CDH1, CD44, CTNNB1, CCND1
47estrogen445.2TERT, VWF, TP53, TIMP2, TIMP1, MMP9
48paraffin445.2MMP9, MMP2, MMP1, CCND1, BIRC5, KRT5
49retinoic acid44 246.0CDH1, CD44, CTNNB1, CDKN2A, KRT5, BIRC5
50serine444.7TERT, VWF, H2AFX, TP53, TIMP2, TIMP1

GO Terms for genes affiliated with Vulvar Intraepithelial Neoplasia

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Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:0056579.4TP53, H2AFX
2catenin complexGO:0163429.1CTNNB1, CDH1
3proteinaceous extracellular matrixGO:0055789.1VWF, MMP9, MMP2, MMP1
4basolateral plasma membraneGO:0163238.4CDH1, CD44, CTNNB1
5extracellular regionGO:0055767.9CDH1, MMP1, MMP2, MMP9, TIMP1, TIMP2
6cytosolGO:0058297.9CTNNB1, CDKN2A, KRT5, BIRC5, CCND1, SOX2
7nucleoplasmGO:0056547.9TERT, H2AFX, TP53, CCND1, CDKN2A, CTNNB1
8cytoplasmGO:0057377.0TERT, TP53, SOX2, BIRC5, KRT5, CDKN2A

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0CCND1, TP53
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.9SOX2, CDH1
3positive regulation of cell cycle arrestGO:0711589.8TP53, CDKN2A
4replicative senescenceGO:0903999.8CDKN2A, TP53, TERT
5collagen catabolic processGO:0305749.8MMP1, MMP2, MMP9
6leukocyte migrationGO:0509009.7MMP9, MMP1, CD44
7cell cycle arrestGO:0070509.7TP53, SOX2, CDKN2A
8epithelial tube branching involved in lung morphogenesisGO:0604419.6CTNNB1, SOX2
9response to X-rayGO:0101659.6TP53, CCND1
10positive regulation of MAPK cascadeGO:0434109.5CTNNB1, SOX2, TIMP2
11positive regulation of neuroblast proliferationGO:0020529.5SOX2, CTNNB1
12response to cytokineGO:0340979.5TIMP2, TIMP1, CTNNB1
13male genitalia developmentGO:0305399.4SOX2, CTNNB1
14regulation of protein localization to cell surfaceGO:20000089.4CDH1, CTNNB1
15cellular response to indole-3-methanolGO:0716819.4CDH1, CTNNB1
16cellular response to DNA damage stimulusGO:0069749.2CCND1, TP53, H2AFX
17liver developmentGO:0018899.1VWF, CCND1, CTNNB1
18blood coagulationGO:0075969.0VWF, TP53, TIMP1, MMP1, CD44
19cell-cell adhesionGO:0163379.0CDH1, CD44, CTNNB1
20negative regulation of cell proliferationGO:0082858.9CTNNB1, CDKN2A, TIMP2, TP53
21negative regulation of apoptotic processGO:0430668.9CD44, BIRC5, TIMP1, TP53
22negative regulation of transcription, DNA-templatedGO:0458928.8TP53, BIRC5, CDKN2A, CTNNB1
23response to drugGO:0424938.8CTNNB1, CDH1, CCND1, TIMP2
24positive regulation of transcription, DNA-templatedGO:0458938.4TP53, SOX2, CDKN2A, CDH1, CTNNB1
25extracellular matrix disassemblyGO:0226178.3CD44, TIMP2, TIMP1, MMP9, MMP2, MMP1
26extracellular matrix organizationGO:0301987.8VWF, TIMP2, TIMP1, MMP9, MMP2, MMP1

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.9TP53, CDKN2A
2metalloendopeptidase inhibitor activityGO:0081919.9TIMP1, TIMP2
3chaperone bindingGO:0510879.5BIRC5, TP53, VWF
4metalloendopeptidase activityGO:0042229.4MMP1, MMP2, MMP9
5collagen bindingGO:0055189.4CD44, MMP9, VWF
6protease bindingGO:0020209.4VWF, TP53, TIMP1
7transcription regulatory region DNA bindingGO:0442129.0CTNNB1, SOX2, TP53
8protein phosphatase bindingGO:0199038.8CTNNB1, CDH1, TP53
9transcription factor bindingGO:0081348.7CTNNB1, CDKN2A, CCND1, TP53
10protein kinase bindingGO:0199018.6TP53, CCND1, CDKN2A, CTNNB1
11identical protein bindingGO:0428028.6VWF, TP53, MMP9, BIRC5
12enzyme bindingGO:0198998.4H2AFX, TP53, CCND1, BIRC5, CTNNB1
13protein bindingGO:0055154.6CTNNB1, TERT, VWF, H2AFX, TP53, TIMP2

Products for genes affiliated with Vulvar Intraepithelial Neoplasia

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Sources for Vulvar Intraepithelial Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet