MCID: VLV044
MIFTS: 56

Vulvar Intraepithelial Neoplasia malady

Reproductive diseases, Cancer diseases, Rare diseases categories
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Summaries for Vulvar Intraepithelial Neoplasia

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65Wikipedia, 33MalaCards
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Wikipedia:65 The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin... more...

MalaCards: Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to cervical intraepithelial neoplasia and papilloma. An important gene associated with Vulvar Intraepithelial Neoplasia is KRT5 (keratin 5), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Glucocorticoid receptor regulatory network. The compounds latanoprost and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are taste/olfaction and pigmentation.

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

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49Orphanet, 62UMLS, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

vulvar intraepithelial neoplasia 49
vulval intraepithelial neoplasia 62
vulvar intraepithelial tumor 49


External Ids:

UMLS via Orphanet63 C0346210
SNOMED-CT via Orphanet59 399933001

Related Diseases for Vulvar Intraepithelial Neoplasia

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17GeneCards, 18GeneDecks
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Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1cervical intraepithelial neoplasia30.8CDKN2A, BIRC5, TERT
2papilloma30.7CDKN2A, KRT5, TP53
3melanoma29.9CTNNB1, CD44, CDH1, CDKN2A, BIRC5, CCND1
4cervicitis10.8
5lichen sclerosus10.7
6vulvovaginitis10.4
7vulva cancer10.4
8blindness10.4
9systemic lupus erythematosus10.3
10acne10.3
11herpes simplex10.3
12lupus erythematosus10.3
13vulvar disease10.3
14t-lymphocytopenia10.3
15trichofolliculoma10.3
16endotheliitis10.3
17meningioma10.1TERT
18actinic keratosis10.1TP53
19turcot syndrome10.1CTNNB1
20arthropathy10.1MMP1, TIMP1
21oral submucous fibrosis10.1MMP1, TIMP1
22oral lichen planus10.1MMP1, TIMP2
23pulpitis10.1MMP1, TIMP1
24craniopharyngioma10.1CTNNB1
25benign meningioma10.1BIRC5, TERT
26fibromatosis10.1CTNNB1, TIMP2
27fibromatosis, gingival10.1MMP1, MMP2
28thoracic aortic aneurysm10.1MMP1, MMP2
29gingival overgrowth10.1MMP1, TIMP1
30synovitis10.1MMP1, TIMP1, TIMP2
31carotid stenosis10.1MMP1, MMP9
32multiple myeloma10.1CD44, CCND1
33middle ear cholesteatoma10.1MMP1, MMP9
34lymphangioleiomyomatosis10.1MMP1, MMP2
35benign mesothelioma10.1KRT5, TP53
36oropharyngeal cancer, adult10.1CDKN2A, TP53
37periodontitis10.1MMP9
38li-fraumeni syndrome10.1CDKN2A, TP53
39pulmonary emphysema10.1MMP1, MMP9, TIMP2
40relapsing-remitting multiple sclerosis10.1MMP9, TIMP1
41gingivitis10.1MMP1, TIMP1
42malignant peripheral nerve sheath tumor10.1CD44, CDKN2A, TERT
43keratoconus10.1MMP1, MMP2, TIMP1
44periodontal disease10.1MMP1, MMP2, TIMP1
45glomerulosclerosis10.1MMP2, TIMP1, TIMP2
46pulmonary disease, chronic obstructive10.1MMP9, TIMP1
47proliferative diabetic retinopathy10.0MMP9, TIMP1, TIMP2
48kawasaki disease10.0MMP9, TIMP1
49hypertrophic scars10.0KRT5, MMP1, MMP2, TIMP1
50aneurysm10.0MMP2, MMP9, TIMP2

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to vulvar intraepithelial neoplasia

Symptoms for Vulvar Intraepithelial Neoplasia

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Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Vulvar Intraepithelial Neoplasia

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

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Anatomical Context for Vulvar Intraepithelial Neoplasia

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33MalaCards
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MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

33
Skin, T cells, Testes, Lung, Endothelial

Animal Models for Vulvar Intraepithelial Neoplasia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2CTNNB1, SOX2, TERT
2MP:00011868.6CTNNB1, CDKN2A, SOX2, TP53
3MP:00053718.2TP53, MMP9, KRT5, CD44, CTNNB1
4MP:00053828.1TP53, SOX2, MMP2, CCND1, KRT5, CTNNB1
5MP:00053697.7TP53, SOX2, MMP9, MMP2, CDKN2A, CD44
6MP:00053807.5TP53, SOX2, BIRC5, CDKN2A, CDH1, CTNNB1
7MP:00030127.5VWF, TP53, SOX2, KRT5, CDKN2A, CDH1
8MP:00053867.3TP53, TIMP2, SOX2, MMP9, CCND1, KRT5
9MP:00053887.2TP53, TIMP1, SOX2, MMP9, MMP2, CCND1
10MP:00053907.2TERT, TP53, SOX2, MMP9, MMP2, CCND1
11MP:00053917.0H2AFX, TP53, SOX2, MMP9, MMP2, CCND1
12MP:00107717.0TP53, SOX2, MMP9, CCND1, KRT5, CDKN2A
13MP:00028736.9TERT, TP53, TIMP2, SOX2, MMP2, CCND1
14MP:00053796.6TERT, H2AFX, TP53, TIMP1, SOX2, CCND1
15MP:00036316.4TIMP2, TP53, VWF, TERT, SOX2, MMP9
16MP:00053816.3TERT, VWF, TP53, SOX2, MMP9, CCND1
17MP:00053896.2TERT, H2AFX, TP53, TIMP1, SOX2, MMP9
18MP:00053856.1VWF, H2AFX, TP53, TIMP1, MMP9, MMP2
19MP:00053785.8SOX2, TIMP1, TP53, H2AFX, TERT, MMP9
20MP:00053845.8SOX2, TP53, H2AFX, VWF, TERT, MMP9
21MP:00053975.7TIMP2, TP53, H2AFX, VWF, TERT, TIMP1
22MP:00020065.6CTNNB1, CD44, CDH1, CDKN2A, CCND1, MMP1
23MP:00053765.2SOX2, TIMP1, TIMP2, TP53, VWF, TERT
24MP:00107684.9SOX2, TIMP1, TP53, H2AFX, VWF, TERT
25MP:00053874.6CTNNB1, TERT, VWF, CD44, CDH1, CDKN2A

Publications for Vulvar Intraepithelial Neoplasia

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52PubMed
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Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. (24399036)
2014
2
Immunohistochemical expression of SOX2 in vulvar intraepithelial neoplasia and squamous cell carcinoma. (23518916)
2013
3
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. (23032420)
2013
4
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. (23190170)
2013
5
Focused ultrasound therapy for vulvar intraepithelial neoplasia in a mice model. (23187305)
2013
6
Anti-HPV16 E2 protein T-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partners. (22590583)
2012
7
Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy. (22913259)
2012
8
Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series. (22207153)
2012
9
Optical coherence tomography in vulvar intraepithelial neoplasia. (23214182)
2012
10
Vulvar intraepithelial neoplasia (VIN 2/3): comparing clinical outcomes and evaluating risk factors for recurrence. (22867736)
2012
11
Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study. (22029821)
2011
12
The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment. (21873951)
2011
13
Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris. (20652114)
2009
14
A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian indigenous women. (18766449)
2009
15
Women's perception of the outcome of the surgical management of vulvar intraepithelial neoplasia. (19160655)
2008
16
Women's experiences with vulvar intraepithelial neoplasia. (19012714)
2008
17
A nonsurgical treatment for vulvar intraepithelial neoplasia. (18769666)
2008
18
Imiquimod 5% cream reduced lesion size in vulvar intraepithelial neoplasia. (18836111)
2008
19
Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia. (16633069)
2006
20
Concordance of gross surgical and final fixed margins in vulvar intraepithelial neoplasia 3 and vulvar cancer. (16967630)
2006
21
Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva. (16998595)
2006
22
Synchronous vulvar intraepithelial neoplasia (VIN) of warty type and cervical intraepithelial neoplasia (CIN): case report. (17183865)
2006
23
Re: "Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients". (16472846)
2006
24
Medical management of vulvar intraepithelial neoplasia. (16205189)
2005
25
Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. (16419625)
2005
26
Treatment of undifferentiated vulvar intraepithelial neoplasia with 5% imiquimod cream: a prospective study of 12 cases. (15492184)
2004
27
The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia, and vulvar lichen sclerosus as determined by microvessel density analysis. (12713988)
2003
28
Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests. (12521370)
2003
29
Loop electrosurgical excision procedure in vulvar intraepithelial neoplasia treatment. (17051029)
2002
30
CO2 laser surgery for vulvar intraepithelial neoplasia. Excisional, destructive and combined techniques. (12497680)
2002
31
Vulvar intraepithelial neoplasia treated with cavitational ultrasonic surgical aspiration. (11925129)
2002
32
Photodynamic therapy of vulvar intraepithelial neoplasia III using topically applied 5-aminolevulinic acid. (11136571)
2001
33
Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women. (10986677)
2000
34
A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. (10999722)
2000
35
Human papillomavirus DNA in multicentric vulvar intraepithelial neoplasia. (9475186)
1998
36
Differentiating vulvar intraepithelial neoplasia from nonneoplastic epithelial disorders. The toluidine blue test. (9749417)
1998
37
Angiogenesis in vulvar intraepithelial neoplasia. (9062159)
1997
38
Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus. (9166302)
1997
39
Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. (9277660)
1997
40
Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Italian Study Group on Vulvar Disease. (8887191)
1996
41
Vulvar intraepithelial neoplasia and vulvar cancer. (8784883)
1996
42
Biologic behavior of vulvar intraepithelial neoplasia. Histologic and clinical parameters. (8383203)
1993
43
Vulvar intraepithelial neoplasia. A clinicopathologic study of 60 cases. (2177508)
1990
44
Prospective randomized trial of topical alpha-interferon (alpha-interferon gels) for the treatment of vulvar intraepithelial neoplasia III. (2182407)
1990
45
Expression of the human papillomavirus type 16 genome in SK-v cells, a line derived from a vulvar intraepithelial neoplasia. (2157796)
1990
46
Unrecognized invasive carcinoma in vulvar intraepithelial neoplasia (VIN). (3410345)
1988
47
Laser surgery for vulvar intraepithelial neoplasia: principles and results. (3826173)
1987
48
Vulvar intraepithelial neoplasia: a report of two cases. (3744920)
1986
49
Vulvar intraepithelial neoplasia (severe atypia and carcinoma in situ). A clinicopathologic analysis of 41 cases. (6088029)
1984
50
Management of vulvar intraepithelial neoplasia by carbon dioxide laser. (6806733)
1982

Variations for Vulvar Intraepithelial Neoplasia

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Expression for genes affiliated with Vulvar Intraepithelial Neoplasia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for genes affiliated with Vulvar Intraepithelial Neoplasia

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 12EMD Millipore, 5Cell Signaling Technology, 57SinoBiological, 54R&D Systems
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Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCND1, MMP1, TIMP1
29.6TP53, MMP1, KRT5
39.6BIRC5, CCND1, MMP2
4
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.5MMP1, TIMP1, TP53
5
Show member pathways
9.4TP53, CCND1, CDKN2A
6
Show member pathways
9.4CDKN2A, CCND1, TP53
79.3MMP9, MMP2, CD44
89.2TIMP2, MMP9, MMP1, CD44
99.2CDH1, SOX2, TP53
109.2H2AFX, TP53, CCND1
119.2TIMP2, TIMP1, MMP9, MMP2
129.2TIMP2, TIMP1, MMP9, MMP2
139.1CCND1, MMP1, MMP2, MMP9
149.1TERT, TP53, MMP9, BIRC5
15
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1TP53, MMP9, CCND1, BIRC5
16
Show member pathways
8.9TIMP2, TIMP1, MMP9, MMP2, MMP1
17
Show member pathways
DNA damage response38
8.9H2AFX, TP53, CCND1, CDKN2A
18
Show member pathways
8.9H2AFX, TP53, CCND1, CDKN2A
19
Show member pathways
Cell cycle38
8.8CDH1, CDKN2A, CCND1, TP53
208.7CTNNB1, CDH1, CCND1
218.6CD44, CDKN2A, CCND1, MMP9, TP53
22
Show member pathways
8.6CD44, MMP1, TIMP1, TP53, VWF
238.6CTNNB1, CDH1, TP53
248.6TP53, CCND1, CDKN2A, CTNNB1
25
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5MMP9, MMP2, CCND1, CTNNB1
268.5TP53, CCND1, CD44, CTNNB1
278.5CTNNB1, CDKN2A, MMP2, TP53
28
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.5VWF, CCND1, CD44, CTNNB1
29
Show member pathways
8.4TERT, H2AFX, TP53, CCND1, BIRC5, CDKN2A
308.3CTNNB1, CD44, CDH1, MMP2
318.3TERT, TP53, CCND1, CDKN2A, CTNNB1
32
Show member pathways
8.3TIMP2, TIMP1, SOX2, CDH1, CTNNB1
338.3SOX2, CCND1, BIRC5, CDH1, CTNNB1
348.3TP53, CCND1, CDH1, CTNNB1
35
Show member pathways
Wnt Signaling Pathway NetPath38
8.3CTNNB1, CDH1, CCND1, TP53
36
Show member pathways
Signal transduction PTEN pathway60
8.0TP53, CCND1, BIRC5, CDH1, CTNNB1
378.0TP53, CCND1, BIRC5, CDH1, CTNNB1
38
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.0TP53, SOX2, CCND1, CDKN2A, CD44, CTNNB1
398.0TP53, MMP1, CCND1, CDH1, CTNNB1
40
Show member pathways
7.9TIMP2, TIMP1, MMP9, MMP2, MMP1, CDH1
41
Show member pathways
7.9TIMP2, TIMP1, MMP9, MMP2, MMP1, CDH1
42
Show member pathways
7.8TERT, TP53, TIMP2, TIMP1, MMP9, MMP2
437.7TP53, MMP9, MMP2, CCND1, CD44, CTNNB1
44
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
7.7H2AFX, TP53, CCND1, CDH1, CTNNB1
457.7TERT, MMP9, MMP2, CCND1, CDH1, CTNNB1
46
Show member pathways
7.6TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
47
Show member pathways
7.2TP53, TIMP2, TIMP1, SOX2, CCND1, CDKN2A
487.0CTNNB1, TP53, MMP9, MMP2, MMP1, CCND1
49
Show member pathways
Signaling Pathways in Glioblastoma38
6.9TP53, MMP9, MMP2, MMP1, CCND1, CDKN2A
506.7TP53, MMP9, MMP2, MMP1, CCND1, BIRC5

Compounds for genes affiliated with Vulvar Intraepithelial Neoplasia

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 245)
idCompoundScoreTop Affiliating Genes
1latanoprost45 1110.2TIMP2, MMP9, MMP1, MMP2, TIMP1
2(4-aminophenyl)mercuric acetate459.2TIMP1, MMP9, MMP2, MMP1, TIMP2
3methyl selenol458.9TIMP1, MMP9, MMP2, TIMP2
4p00001458.8CDH1, CDKN2A, TIMP2, CCND1, CD44, BIRC5
5crcs458.1CDH1, CDKN2A, BIRC5, CCND1, TP53, CTNNB1
6depsipeptide458.0CDH1, CDKN2A, CCND1, MMP2, TP53, H2AFX
7roscovitine458.0CTNNB1, BIRC5, CCND1, TP53, H2AFX, CDKN2A
812-o-tetradecanoylphorbol 13-acetate458.0TIMP1, MMP9, KRT5, CD44, TIMP2, CDH1
9doxycycline45 118.9CTNNB1, TIMP1, CDKN2A, MMP9, MMP2, MMP1
10methotrexate51 45 119.9CDH1, CDKN2A, BIRC5, CCND1, MMP1, MMP2
11celecoxib45 61 29 51 24 1112.8MMP2, CTNNB1, CDH1, BIRC5, MMP1, MMP9
12p002457.8CDH1, CD44, BIRC5, TIMP1, MMP9, TIMP2
13hyaluronic acid45 248.8CD44, VWF, TIMP2, TIMP1, MMP2, MMP1
14vitamin a45 24 119.7MMP1, CTNNB1, VWF, KRT5, BIRC5, MMP2
15etoposide45 51 61 1110.6CDH1, BIRC5, CD44, H2AFX, TP53, TERT
16tgf beta1457.5CDH1, CCND1, MMP1, MMP2, MMP9, CTNNB1
17adriamycin457.5CDKN2A, CTNNB1, CD44, CCND1, CDH1, BIRC5
185fluorouracil457.5TIMP2, BIRC5, TERT, TP53, CTNNB1, MMP2
19herbimycin a45 618.5TIMP1, MMP9, MMP1, MMP2, CDH1, CTNNB1
20lactate457.5TIMP2, TIMP1, VWF, MMP9, CD44, MMP2
21arsenite45 248.3CTNNB1, CDKN2A, BIRC5, CCND1, MMP1, MMP9
22pge2457.2MMP1, TIMP1, CD44, CDH1, MMP9, MMP2
23curcumin457.1CTNNB1, CDH1, BIRC5, CCND1, TP53, MMP1
24pd 98,059457.1CDH1, CTNNB1, BIRC5, CCND1, TERT, TIMP2
25h2o2457.1CTNNB1, MMP1, VWF, TP53, TIMP1, MMP2
26cytochalasin d45 618.0CTNNB1, CD44, VWF, TIMP1, MMP9, MMP2
27wortmannin456.9CTNNB1, BIRC5, CCND1, MMP2, MMP9, H2AFX
28sb 20358045 617.9TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
29cycloheximide456.9TP53, TIMP2, TIMP1, MMP9, MMP2, MMP1
30paclitaxel45 51 118.8TERT, TP53, TIMP2, TIMP1, MMP1, CCND1
31doxorubicin45 51 118.7TERT, H2AFX, TP53, MMP1, CCND1, BIRC5
32matrigel456.7VWF, TIMP2, TIMP1, MMP9, MMP2, MMP1
33cisplatin45 51 61 119.7H2AFX, CTNNB1, CD44, CDKN2A, BIRC5, CDH1
34butyrate456.6CCND1, MMP9, TIMP1, TIMP2, TP53, TERT
35genistein45 29 61 3 24 1111.6TERT, TIMP2, TIMP1, MMP9, MMP2, MMP1
36alanine456.5MMP9, CTNNB1, CD44, CDH1, CDKN2A, BIRC5
37phosphatidylinositol456.5CCND1, MMP9, CTNNB1, MMP2, TIMP1, CDH1
38progesterone45 29 61 24 1110.5CDH1, CD44, CTNNB1, CDKN2A, KRT5, TP53
39cysteine456.3MMP1, MMP2, CD44, MMP9, TIMP2, VWF
40arginine456.3CDKN2A, CTNNB1, CD44, CDH1, TIMP1, TP53
41egcg456.3CTNNB1, CDH1, CDKN2A, BIRC5, CCND1, MMP1
42testosterone45 61 24 119.2KRT5, CDKN2A, CDH1, CD44, CTNNB1, BIRC5
43ly294002456.0TP53, TIMP2, TIMP1, MMP9, MMP2, CCND1
44tyrosine455.9MMP9, CTNNB1, CD44, KRT5, BIRC5, CCND1
45n acetylcysteine455.5CTNNB1, H2AFX, VWF, TERT, CDH1, CDKN2A
46vegf455.4BIRC5, CDKN2A, CDH1, CD44, CTNNB1, CCND1
47estrogen455.2TERT, VWF, TP53, TIMP2, TIMP1, MMP9
48paraffin455.2MMP9, MMP2, MMP1, CCND1, BIRC5, KRT5
49retinoic acid45 246.0CDH1, CD44, CTNNB1, CDKN2A, KRT5, BIRC5
50serine454.7TERT, VWF, H2AFX, TP53, TIMP2, TIMP1

GO Terms for genes affiliated with Vulvar Intraepithelial Neoplasia

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16Gene Ontology
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Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:0056579.4TP53, H2AFX
2catenin complexGO:0163429.1CTNNB1, CDH1
3proteinaceous extracellular matrixGO:0055789.1VWF, MMP9, MMP2, MMP1
4basolateral plasma membraneGO:0163238.4CDH1, CD44, CTNNB1
5extracellular regionGO:0055767.9CDH1, MMP1, MMP2, MMP9, TIMP1, TIMP2
6cytosolGO:0058297.9CTNNB1, CDKN2A, KRT5, BIRC5, CCND1, SOX2
7nucleoplasmGO:0056547.9TERT, H2AFX, TP53, CCND1, CDKN2A, CTNNB1
8cytoplasmGO:0057377.0TERT, TP53, SOX2, BIRC5, KRT5, CDKN2A

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0CCND1, TP53
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.9SOX2, CDH1
3positive regulation of cell cycle arrestGO:0711589.8TP53, CDKN2A
4replicative senescenceGO:0903999.8CDKN2A, TP53, TERT
5collagen catabolic processGO:0305749.8MMP1, MMP2, MMP9
6leukocyte migrationGO:0509009.7MMP9, MMP1, CD44
7cell cycle arrestGO:0070509.7TP53, SOX2, CDKN2A
8epithelial tube branching involved in lung morphogenesisGO:0604419.6CTNNB1, SOX2
9response to X-rayGO:0101659.6TP53, CCND1
10positive regulation of MAPK cascadeGO:0434109.5CTNNB1, SOX2, TIMP2
11positive regulation of neuroblast proliferationGO:0020529.5SOX2, CTNNB1
12response to cytokineGO:0340979.5TIMP2, TIMP1, CTNNB1
13male genitalia developmentGO:0305399.4SOX2, CTNNB1
14regulation of protein localization to cell surfaceGO:20000089.4CDH1, CTNNB1
15cellular response to indole-3-methanolGO:0716819.4CDH1, CTNNB1
16cellular response to DNA damage stimulusGO:0069749.2CCND1, TP53, H2AFX
17liver developmentGO:0018899.1VWF, CCND1, CTNNB1
18blood coagulationGO:0075969.0VWF, TP53, TIMP1, MMP1, CD44
19cell-cell adhesionGO:0163379.0CDH1, CD44, CTNNB1
20negative regulation of cell proliferationGO:0082858.9CTNNB1, CDKN2A, TIMP2, TP53
21negative regulation of apoptotic processGO:0430668.9CD44, BIRC5, TIMP1, TP53
22negative regulation of transcription, DNA-templatedGO:0458928.8TP53, BIRC5, CDKN2A, CTNNB1
23response to drugGO:0424938.8CTNNB1, CDH1, CCND1, TIMP2
24positive regulation of transcription, DNA-templatedGO:0458938.4TP53, SOX2, CDKN2A, CDH1, CTNNB1
25extracellular matrix disassemblyGO:0226178.3CD44, TIMP2, TIMP1, MMP9, MMP2, MMP1
26extracellular matrix organizationGO:0301987.8VWF, TIMP2, TIMP1, MMP9, MMP2, MMP1

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.9TP53, CDKN2A
2metalloendopeptidase inhibitor activityGO:0081919.9TIMP1, TIMP2
3chaperone bindingGO:0510879.5BIRC5, TP53, VWF
4metalloendopeptidase activityGO:0042229.4MMP1, MMP2, MMP9
5collagen bindingGO:0055189.4CD44, MMP9, VWF
6protease bindingGO:0020209.4VWF, TP53, TIMP1
7transcription regulatory region DNA bindingGO:0442129.0CTNNB1, SOX2, TP53
8protein phosphatase bindingGO:0199038.8CTNNB1, CDH1, TP53
9transcription factor bindingGO:0081348.7CTNNB1, CDKN2A, CCND1, TP53
10protein kinase bindingGO:0199018.6TP53, CCND1, CDKN2A, CTNNB1
11identical protein bindingGO:0428028.6VWF, TP53, MMP9, BIRC5
12enzyme bindingGO:0198998.4H2AFX, TP53, CCND1, BIRC5, CTNNB1
13protein bindingGO:0055154.6CTNNB1, TERT, VWF, H2AFX, TP53, TIMP2

Products for genes affiliated with Vulvar Intraepithelial Neoplasia

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Sources for Vulvar Intraepithelial Neoplasia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet