MCID: VLV044
MIFTS: 47

Vulvar Intraepithelial Neoplasia malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

Aliases & Descriptions for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 56
Vulval Intraepithelial Neoplasia 69
Vulvar Intraepithelial Tumor 56

Classifications:



External Ids:

Orphanet 56 ORPHA137583
ICD10 via Orphanet 34 D07.1
UMLS via Orphanet 70 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

MalaCards based summary : Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to vulva cancer and squamous cell carcinoma, and has symptoms including pruritus and macule. An important gene associated with Vulvar Intraepithelial Neoplasia is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. The drugs Vaccines and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 71 The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin... more...

Related Diseases for Vulvar Intraepithelial Neoplasia

Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 vulva cancer 11.4
2 squamous cell carcinoma 10.5
3 facio skeletal genital syndrome rippberger type 10.4 MMP2 MMP9
4 cervicitis 10.4
5 linitis plastica 10.3 CDH1 TP53
6 kleptomania 10.3 MMP1 MMP2 MMP9
7 senile atrophy of choroid 10.3 MMP1 MMP2 MMP9
8 linear porokeratosis 10.3 MMP1 MMP2 MMP9
9 clear cell adenofibroma 10.3 CDKN2A TP53
10 onychocytic matricoma 10.3 MMP1 MMP2 MMP9
11 gallbladder papillomatosis 10.3 BIRC5 MMP2 TP53
12 appendix carcinoid tumor 10.3 MMP2 MMP9 TIMP1
13 statin toxicity 10.3 BIRC5 MMP9 TP53
14 lacrimal gland adenoid cystic carcinoma 10.3 CDKN2A TP53
15 laryngostenosis 10.3 MMP1 MMP2 MMP9
16 chondrodysplasia punctata, rhizomelic, type 1 10.3 CDH1 MMP9 TIMP1
17 zika fever 10.3 MMP1 MMP2 TIMP1
18 spinal meninges cancer 10.3 CTNNB1 MMP2 MMP9
19 lichen sclerosus 10.2
20 esophageal neuroendocrine tumor 10.2 CDH1 MMP2 TIMP1
21 lower lip cancer 10.2 BIRC5 MMP2 MMP9
22 cervical verrucous carcinoma 10.2 CDKN2A KRT10 TP53
23 vascular myelopathy 10.2 CDKN2A SOX2 TP53
24 mitochondrial encephalomyopathy 10.2 CDKN2A MMP2 TP53
25 charcot-marie-tooth disease type 2n 10.2 BIRC5 CDKN2A TERT
26 optic nerve neoplasm 10.2 MMP1 MMP9 TIMP1
27 pityriasis rosea 10.2 CDKN2A TIMP2 TP53
28 schwannomatosis 10.2 MMP2 MMP9 TIMP1 TIMP2
29 central nervous system teratoma 10.2 MMP1 MMP2 MMP9 TIMP1
30 retinal drusen 10.2 MMP2 MMP9 TIMP1 TIMP2
31 breast papillary carcinoma 10.2 CDH1 MMP2 MMP9 TIMP1
32 angiomyoma 10.2 MMP1 MMP2 TIMP1 TIMP2
33 renal oncocytoma 10.2 MMP1 MMP9 TIMP1 TIMP2
34 megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 10.2 KRT10 KRT5 TP53
35 ideomotor apraxia 10.2 CDH1 CTNNB1 TP53
36 histiocytosis 10.2 MMP1 MMP2 MMP9 TIMP1
37 acute tricyclic antidepressant poisoning 10.2 MMP2 MMP9
38 marginal zone b-cell lymphoma 10.2 CDKN2A MMP2 MMP9 TP53
39 fallopian tube leiomyosarcoma 10.2 CDH1 CDKN2A TP53
40 lattice corneal dystrophy 10.2 CDKN2A MMP2 MMP9 TP53
41 spinal cord oligodendroglioma 10.2 CDKN2A KRT5 TP53
42 puerperal pulmonary embolism 10.2 MMP2 MMP9 TIMP1 TIMP2
43 connective tissue benign neoplasm 10.2 CDH1 CDKN2A TP53
44 basaloid squamous cell carcinoma 10.2 CDH1 KRT10 KRT5
45 vascular dementia 10.2 KRT10 MMP2 MMP9
46 hepatic flexure cancer 10.2 CDKN2A MMP2 TERT TP53
47 hypotrichosis 8 10.2 CDKN2A MMP2 MMP9 TP53
48 subglottis neoplasm 10.2 CDKN2A MMP1 MMP2 TIMP2
49 pseudo-meigs syndrome 10.2 CDH1 CDKN2A CTNNB1
50 glucosephosphate isomerase deficiency 10.2 CDKN2A MMP2 MMP9 TP53

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to Vulvar Intraepithelial Neoplasia

Symptoms & Phenotypes for Vulvar Intraepithelial Neoplasia

UMLS symptoms related to Vulvar Intraepithelial Neoplasia:


pruritus, macule

MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 BIRC5 CTNNB1 CDH1 H2AFX CDKN2A HAVCR2
2 homeostasis/metabolism MP:0005376 10.3 BIRC5 CTNNB1 CDH1 H2AFX CDKN2A KLRC1
3 hematopoietic system MP:0005397 10.22 BIRC5 CTNNB1 H2AFX CDKN2A HAVCR2 KLRC1
4 immune system MP:0005387 10.22 KLRC1 CTNNB1 BIRC5 CDH1 H2AFX CDKN2A
5 cardiovascular system MP:0005385 10.21 CDKN2A CTNNB1 CDH1 H2AFX MMP9 MMP2
6 growth/size/body region MP:0005378 10.21 HAVCR2 CDKN2A CTNNB1 CDH1 H2AFX MMP9
7 endocrine/exocrine gland MP:0005379 10.16 BIRC5 CTNNB1 CDH1 H2AFX CDKN2A RPS6
8 digestive/alimentary MP:0005381 10.13 CTNNB1 CDH1 CDKN2A MMP9 KRT5 SOX2
9 mortality/aging MP:0010768 10.1 CDKN2A HAVCR2 BIRC5 CTNNB1 CDH1 H2AFX
10 neoplasm MP:0002006 9.9 CTNNB1 CDH1 H2AFX CDKN2A TIMP1 SOX2
11 reproductive system MP:0005389 9.61 CDKN2A CTNNB1 CDH1 H2AFX TERT MMP9
12 respiratory system MP:0005388 9.28 CTNNB1 CDKN2A KLRC1 SOX2 MMP2 TERT

Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

Drugs for Vulvar Intraepithelial Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2
2
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
3
Aluminum hydroxide Approved Phase 3 21645-51-2
4
Menthol Approved Phase 3 2216-51-5 16666
5 interferons Phase 2, Phase 3
6 Adjuvants, Immunologic Phase 2, Phase 3
7 Interferon Inducers Phase 2, Phase 3
8 Aluminum sulfate Phase 3
9 Anesthetics Phase 3
10 Immunosuppressive Agents

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions Not yet recruiting NCT03051516 Phase 4
2 Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines Not yet recruiting NCT03180034 Phase 4
3 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
4 A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia Completed NCT00394758 Phase 3
5 ITIC (Imiquimod Therapy in Cervical Intraepithelial Neoplasia)-Trial Completed NCT00941252 Phase 2, Phase 3
6 A Study to Evaluate the Safety, Immune Response, and Efficacy of Gardasil (V501, qHPV) in Mid-Adult Women (V501-019) Completed NCT00090220 Phase 3
7 Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia Recruiting NCT01861535 Phase 3
8 Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent(Type 16/18 )Vaccine Active, not recruiting NCT01735006 Phase 3
9 A Bridging Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Active, not recruiting NCT02562508 Phase 3
10 Imiquimod Treatment of CIN Lesions Terminated NCT02329171 Phase 3
11 Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Terminated NCT00577317 Phase 3
12 Immunevasion of Human Papillomavirus (HPV) in Vulvar Intraepithelial Neoplasia 2/3 and Anogenital Warts and Efficiency and Mechanisms of Imiquimod Treatment Completed NCT00941811 Phase 2
13 The Impact of the "WOMAN-PRO II Program" on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence Completed NCT01986725 Phase 2
14 Dose-Ranging Study of Quadrivalent Human Papillomavirus (HPV) (Types 6,11,16,18) L1 Virus-Like Particle (VLP) Vaccine (V501-007)(COMPLETED) Completed NCT00365716 Phase 2
15 Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With uVIN Active, not recruiting NCT02596074 Phase 2
16 VGX-3100 Followed by Electroporation Alone or in Combination With Imiquimod for the Treatment of Human Papilloma Virus HPV-16 and/or HPV-18 Related High Grade Squamous Intraepithelial Lesion (HSIL) of the Vulva Not yet recruiting NCT03180684 Phase 2
17 A New Patient Reported Outcome Instrument to Assess Symptom Experience in Women With Vulvar Neoplasms (WOMAN-PRO) Unknown status NCT01300663
18 SR-T100 Gel Efficacy & Safety Study for Vulva Pre-cancerous Lesions & Cutaneous Condyloma Completed NCT01676792 Early Phase 1
19 Immunogenicity to Human Papillomavirus Vaccine (Gardasil) Among IBD Patients on Immunosuppressive Therapy Completed NCT00727636
20 GARDASIL™ Vaccine Impact in Population Study (V501-033) Completed NCT01077856
21 Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia Recruiting NCT02875561
22 Prevalence of Anal Dysplasia and Anal Cancer in Women With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021
23 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Recruiting NCT02735109
24 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Recruiting NCT02223975
25 Long-term Follow-up of Broad Spectrum Human Papillomavirus (HPV) Vaccine Study in Women (V503-021) Active, not recruiting NCT02653118
26 Evaluation of Long-term HPV Vaccine Efficacy Enrolling by invitation NCT01393470
27 Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Not yet recruiting NCT03061435
28 Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis Not yet recruiting NCT03052556
29 Colposcopy and High Resolution Anoscopy in Screening For Anal Dysplasia in Patients With Cervical, Vaginal, or Vulvar Dysplasia or Cancer Withdrawn NCT01313104

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

Anatomical Context for Vulvar Intraepithelial Neoplasia

MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

39
Skin, T Cells, Testes, Endothelial, Lung

Publications for Vulvar Intraepithelial Neoplasia

Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50) (show all 228)
id Title Authors Year
1
Committee Opinion No. 675: Management of Vulvar Intraepithelial Neoplasia: Correction. ( 28092302 )
2017
2
The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges. ( 26974999 )
2016
3
Committee Opinion No.675: Management of Vulvar Intraepithelial Neoplasia. ( 27661656 )
2016
4
Extra-Genital Bowen's Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia. ( 27298533 )
2016
5
Vulvar intraepithelial neoplasia grade 3 associated with BehAset's disease. ( 26983442 )
2016
6
Differentiated Vulvar Intraepithelial Neoplasia: What Criteria Do We Use in Practice? ( 27105329 )
2016
7
Distinguishing Erosive Lichen Planus From Differentiated Vulvar Intraepithelial Neoplasia. ( 26796658 )
2016
8
Type-specific HPV infection correlates with risk of recurrence of vulvar intraepithelial neoplasia usual type. ( 28006842 )
2016
9
Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia. ( 27513074 )
2016
10
Medical and Surgical Treatments for Usual-Type Vulvar Intraepithelial Neoplasia. ( 27490514 )
2016
11
Vulvar intraepithelial neoplasia: clinical presentation, management and outcomes in women infected with HIV. ( 26959352 )
2016
12
Vulvar and Vaginal Cancer, Vulvar Intraepithelial Neoplasia 3 and Vaginal Intraepithelial Neoplasia 3: Experience of a Referral Institute. ( 27430086 )
2016
13
Usual-type vulvar intraepithelial neoplasia: report of a case and its dermoscopic features. ( 27419656 )
2016
14
MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia. ( 27399691 )
2016
15
Committee Opinion No. 675 Summary: Management of Vulvar Intraepithelial Neoplasia. ( 27661648 )
2016
16
Dermoscopic findings of vulvar intraepithelial neoplasia (VIN): a series of 4 cases. ( 27291788 )
2016
17
No viral association found in a set of differentiated vulvar intraepithelial neoplasia cases by human papillomavirus and pan-viral microarray testing. ( 25894343 )
2015
18
Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: A review. ( 26335596 )
2015
19
LASER VAPORIZATION IN VULVAR INTRAEPITHELIAL NEOPLASIA (VIN), VAGINAL INTRAEPITHELIAL NEOPLASIA (VAIN) AND CONDYLOMATA ACUMINATA: IGCS-0093 Vulvar and Vaginal Cancer. ( 25955950 )
2015
20
Efficacy of 5% imiquimod cream on vulvar intraepithelial neoplasia in Korea: pilot study. ( 25673934 )
2015
21
Vulvar Intraepithelial Neoplasia (VIN) and Condylomata. ( 26133495 )
2015
22
Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series. ( 25149547 )
2014
23
Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy. ( 24415578 )
2014
24
Surgical treatment of usual type vulvar intraepithelial neoplasia: a study at three academic hospitals. ( 24534242 )
2014
25
Vulvar intraepithelial neoplasia. ( 25106700 )
2014
26
Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival. ( 25220367 )
2014
27
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. ( 24399036 )
2014
28
Aberrant staining patterns of E-cadherin and I^-catenin: a potential diagnostic value for distinguishing vulvar intraepithelial neoplasia from non-neoplastic vulvar lesions. ( 23826417 )
2013
29
Quality of life and female sexual function after skinning vulvectomy with split-thickness skin graft in women with vulvar intraepithelial neoplasia or vulvar Paget disease. ( 24090498 )
2013
30
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. ( 23190170 )
2013
31
Treatment of vulvar intraepithelial neoplasia with CO(2) laser vaporization and excision surgery. ( 23609594 )
2013
32
Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: independent lesions due to different HPV types occurring in immunocompromised patients. ( 23026935 )
2013
33
Immunohistochemical expression of SOX2 in vulvar intraepithelial neoplasia and squamous cell carcinoma. ( 23518916 )
2013
34
The use of argon beam coagulation in treating vulvar intraepithelial neoplasia III: a retrospective review. ( 23887037 )
2013
35
Fascin and cyclin D1 immunoreactivity in non-neoplastic vulvar squamous epithelium, vulvar intraepithelial neoplasia and invasive squamous carcinoma: correlation with Ki67 and p16 protein expression. ( 24218024 )
2013
36
Clinical characteristics associated with development of recurrence and progression in usual-type vulvar intraepithelial neoplasia. ( 24257562 )
2013
37
Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia. ( 23765247 )
2013
38
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. ( 23032420 )
2013
39
Treatment of vulvar intraepithelial neoplasia with topical 5% imiquimod cream. ( 23219095 )
2013
40
Focused ultrasound therapy for vulvar intraepithelial neoplasia in a mice model. ( 23187305 )
2013
41
Interobserver variability and the effect of education in the histopathological diagnosis of differentiated vulvar intraepithelial neoplasia. ( 23370772 )
2013
42
Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series. ( 22207153 )
2012
43
Human papillomavirus distribution in vulvar intraepithelial neoplasia. ( 22300742 )
2012
44
Optical coherence tomography in vulvar intraepithelial neoplasia. ( 23214182 )
2012
45
Prevalence of human papillomavirus types in invasive vulvar cancers and vulvar intraepithelial neoplasia 3 in the United States before vaccine introduction. ( 22652576 )
2012
46
Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy. ( 22913259 )
2012
47
Management of vulvar intraepithelial neoplasia. ( 22020407 )
2012
48
Photodynamic therapy of vulvar intraepithelial neoplasia using methyl aminolevulinate. ( 21254852 )
2012
49
CO2 laser total superficial vulvectomy: an outpatient treatment for wide multifocal vulvar intraepithelial neoplasia grade 3. ( 23084682 )
2012
50
A multicenter study of the clinical characteristics of usual-type vulvar intraepithelial neoplasia in China. ( 22261126 )
2012

Variations for Vulvar Intraepithelial Neoplasia

Expression for Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for Vulvar Intraepithelial Neoplasia

Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 36)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 BIRC5 CDH1 CTNNB1 HAVCR2 KLRC1 MMP1
2
Show member pathways
13.46 CTNNB1 H2AFX KRT10 KRT5 KRT7 MMP2
3
Show member pathways
13.26 BIRC5 HAVCR2 MMP1 MMP2 MMP9 SOX2
4
Show member pathways
12.95 CDH1 CDKN2A CTNNB1 MMP2 MMP9 RPS6
5
Show member pathways
12.69 CDH1 MMP1 MMP2 MMP9 TIMP1 TIMP2
6
Show member pathways
12.56 BIRC5 CTNNB1 MMP2 TIMP1 TP53
7
Show member pathways
12.51 CDH1 CTNNB1 MMP2 MMP9 TP53
8 12.46 BIRC5 CDH1 CDKN2A CTNNB1 MMP1 MMP2
9 12.38 CDKN2A CTNNB1 TERT TP53
10
Show member pathways
12.31 BIRC5 CDH1 CTNNB1 TP53
11 12.23 CTNNB1 MMP2 MMP9 RPS6 TP53
12
Show member pathways
12.21 MMP1 RPS6 TIMP1 TP53
13 12.12 BIRC5 CDH1 CTNNB1 SOX2
14 12.11 CDH1 CTNNB1 MMP1 TP53
15 12.06 CTNNB1 MMP2 MMP9 TP53
16 11.93 CDH1 CTNNB1 MMP2 MMP9
17 11.92 BIRC5 CDH1 CTNNB1 MMP1 MMP2 MMP9
18
Show member pathways
11.83 MMP1 MMP2 MMP9 TIMP1 TIMP2
19 11.75 KRT5 MMP1 TP53
20 11.74 MMP2 MMP9 TIMP1 TIMP2 VWF
21 11.72 BIRC5 MMP9 TERT TP53
22 11.69 BIRC5 CDKN2A TP53
23 11.68 CDKN2A CTNNB1 MMP2 TP53
24 11.66 CDH1 CTNNB1 MMP2 MMP9 TERT
25 11.58 MMP2 MMP9 TERT TIMP1
26
Show member pathways
11.56 BIRC5 MMP1 MMP2 MMP9
27 11.53 BIRC5 MMP1 TP53
28 11.52 CDKN2A MMP2 TP53
29 11.5 MMP1 MMP2 MMP9 TIMP1 TIMP2
30 11.37 MMP1 MMP9 TIMP2
31 11.31 MMP1 MMP2 MMP9
32 11.3 CDH1 CDKN2A MMP1 MMP2 MMP9 TP53
33 11.22 BIRC5 MMP1 MMP2 MMP9 SOX2 TIMP1
34 11.21 CDH1 CTNNB1 TP53
35 11.11 MMP9 TIMP1 TIMP2
36 10.78 CDH1 CTNNB1

GO Terms for Vulvar Intraepithelial Neoplasia

Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 CDH1 CTNNB1 H2AFX HAVCR2 KRT10 KRT5
2 proteinaceous extracellular matrix GO:0005578 9.43 MMP1 MMP2 MMP9 TIMP1 TIMP2 VWF
3 catenin complex GO:0016342 9.32 CDH1 CTNNB1
4 flotillin complex GO:0016600 9.26 CDH1 CTNNB1
5 extracellular matrix GO:0031012 9.1 MMP1 MMP2 MMP9 TIMP1 TIMP2 VWF

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.8 BIRC5 MMP9 RPS6 TERT TIMP1 TP53
2 positive regulation of apoptotic process GO:0043065 9.77 CDKN2A CTNNB1 MMP9 RPS6 TP53
3 positive regulation of MAPK cascade GO:0043410 9.67 CTNNB1 SOX2 TIMP2
4 collagen catabolic process GO:0030574 9.63 MMP1 MMP2 MMP9
5 entry of bacterium into host cell GO:0035635 9.48 CDH1 CTNNB1
6 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.43 TIMP1 TIMP2
7 cellular response to indole-3-methanol GO:0071681 9.4 CDH1 CTNNB1
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.33 MMP2 MMP9 TERT
9 negative regulation of metallopeptidase activity GO:1905049 9.26 TIMP1 TIMP2
10 replicative senescence GO:0090399 9.13 CDKN2A TERT TP53
11 extracellular matrix disassembly GO:0022617 9.1 CDH1 MMP1 MMP2 MMP9 TIMP1 TIMP2

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.26 TIMP1 TIMP2 TP53 VWF
2 chaperone binding GO:0051087 8.92 BIRC5 TERT TP53 VWF
3 protein binding GO:0005515 10.11 BIRC5 CDH1 CDKN2A CTNNB1 H2AFX HAVCR2

Sources for Vulvar Intraepithelial Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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