MCID: VLV038
MIFTS: 30

Vulvar Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Sarcoma

MalaCards integrated aliases for Vulvar Sarcoma:

Name: Vulvar Sarcoma 12 14
Sarcoma of Vulva 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2096
NCIt 47 C40317
SNOMED-CT 64 254897006
UMLS 69 C0238525

Summaries for Vulvar Sarcoma

MalaCards based summary : Vulvar Sarcoma, also known as sarcoma of vulva, is related to vulvar alveolar soft part sarcoma and thymus large cell carcinoma. An important gene associated with Vulvar Sarcoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and B Cell Development Pathways. The drugs Octreotide and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include prostate and liver, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Vulvar Sarcoma

Diseases related to Vulvar Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Related Disease Score Top Affiliating Genes
1 vulvar alveolar soft part sarcoma 11.0
2 thymus large cell carcinoma 10.6 EWSR1 SMARCB1
3 spondyloepimetaphyseal dysplasia, isidor type 10.5 EWSR1 PTPRC
4 pediatric osteosarcoma 10.5 EWSR1 TWIST1
5 anal canal adenocarcinoma 10.4 EWSR1 PTPRC
6 juxtacortical osteosarcoma 10.4 EWSR1 PTPRC
7 thyroid cancer, nonmedullary, 4 10.4 EWSR1 SMARCB1
8 superior mesenteric artery syndrome 10.3 KRT7 TWIST1
9 gastric tubular adenocarcinoma 10.3 AR KRT7
10 ovarian mucinous adenocarcinoma 10.3 KRT7 PTPRC
11 hordeolum 10.3 AR KRT7
12 bowman's membrane folds or rupture 10.3 AR KRT7
13 uterine benign neoplasm 10.3 KRT7 PTPRC
14 rectum lymphoma 10.3 KRT7 PTPRC
15 pemphigus vulgaris, familial 10.3 AR KRT7
16 kidney clear cell sarcoma 10.3 AR KRT7
17 lung benign neoplasm 10.3 EWSR1 PTPRC SMARCB1
18 cerebrum cancer 10.2 EWSR1 PTPRC SMARCB1
19 cystic basal cell carcinoma 10.2 AR KRT7
20 prostate small cell carcinoma 10.2 AR KRT7
21 dextrocardia with situs inversus 10.2 EWSR1 PTPRC
22 cervical adenoma malignum 10.1 CD34 EWSR1
23 cutaneous liposarcoma 10.1 CD34 SMARCB1
24 hyperbiliverdinemia 10.1 EWSR1 KRT7 SMARCB1
25 filamentary keratitis 10.1 CD34 PTPRC
26 vestibule of mouth cancer 10.1 CD34 PTPRC
27 salivary gland adenoid cystic carcinoma 10.1 CD34 PTPRC
28 hyperlucent lung 10.0 CD34 TWIST1
29 pericoronitis 10.0 CD34 PTPRC
30 fallopian tube squamous cell carcinoma 10.0 CD34 PTPRC
31 gum cancer 10.0 CD34 PTPRC
32 connective tissue benign neoplasm 10.0 CD34 EWSR1
33 brain stem infarction 10.0 CD34 PTPRC
34 plantar fasciitis 10.0 CD34 SMARCB1
35 peritoneal benign neoplasm 10.0 CD34 SMARCB1
36 leydig cell tumor 9.9 CD34 EWSR1
37 bronchiolo-alveolar adenocarcinoma 9.9 CD34 KRT7
38 acneiform dermatitis 9.9 CD34 PTPRC
39 rare endometriosis 9.9 H2AFX KRT7
40 sarcoma 9.9
41 sick building syndrome 9.8 CD34 EWSR1 SMARCB1
42 fibrosarcoma of bone 9.8 CD34 EWSR1 SMARCB1
43 small cell sarcoma 9.8 CD34 EWSR1 SMARCB1
44 serous cystadenocarcinoma 9.8 KRT7 PTPRC
45 mediastinum rhabdomyosarcoma 9.8 CD34 EWSR1
46 spindle cell sarcoma 9.8 EWSR1 PTPRC
47 epicardium cancer 9.7 CD34 KRT7
48 nodular tenosynovitis 9.7 CD34 KRT7
49 gestational choriocarcinoma 9.7 CD34 EWSR1
50 epithelioid cell synovial sarcoma 9.7 CD34 KRT7 SMARCB1

Graphical network of the top 20 diseases related to Vulvar Sarcoma:



Diseases related to Vulvar Sarcoma

Symptoms & Phenotypes for Vulvar Sarcoma

MGI Mouse Phenotypes related to Vulvar Sarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 AR CD34 GPX1 H2AFX KRT7 PTPRC
2 homeostasis/metabolism MP:0005376 9.76 CD34 GPX1 H2AFX KRT7 PTPRC SMARCB1
3 hematopoietic system MP:0005397 9.73 AR CD34 GPX1 H2AFX PTPRC SMARCB1
4 digestive/alimentary MP:0005381 9.72 AR GPX1 PTPRC SMARCB1 TWIST1
5 immune system MP:0005387 9.43 AR CD34 GPX1 H2AFX PTPRC SMARCB1
6 neoplasm MP:0002006 9.02 AR CD34 H2AFX PTPRC SMARCB1

Drugs & Therapeutics for Vulvar Sarcoma

Drugs for Vulvar Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Dehydroepiandrosterone Approved, Nutraceutical Phase 3 53-43-0 9860744
4 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
5 Antineoplastic Agents, Hormonal Phase 3
6 Gastrointestinal Agents Phase 3
7 Adjuvants, Anesthesia Phase 3
8 Analgesics Phase 3
9 Analgesics, Opioid Phase 3
10 Anesthetics Phase 3
11 Anesthetics, General Phase 3
12 Anesthetics, Intravenous Phase 3
13 Central Nervous System Depressants Phase 3
14 Liver Extracts Phase 3,Phase 1
15 Narcotics Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Adjuvants, Immunologic Phase 3
18 Cola Nutraceutical Phase 3,Phase 1
19 DHEA (Dehydroepiandrosterone) Nutraceutical Phase 3
20 Fondaparinux Investigational Phase 2 104993-28-4
21 Anticoagulants Phase 2
22 Fibrinolytic Agents Phase 2
23 PENTA Phase 2
24
Topotecan Approved, Investigational Phase 1 119413-54-6, 123948-87-8 60700
25
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
26
Gemcitabine Approved Phase 1 95058-81-4 60750
27
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
28
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
29
Entinostat Investigational Phase 1 209783-80-2
30
Camptothecin Experimental Phase 1 7689-03-4
31 topoisomerase I inhibitors Phase 1
32 Topoisomerase Inhibitors Phase 1
33 Antimitotic Agents Phase 1
34 Anti-Infective Agents Phase 1
35 Antimetabolites Phase 1
36 Antimetabolites, Antineoplastic Phase 1
37 Antiviral Agents Phase 1
38 Immunosuppressive Agents Phase 1
39 Histone Deacetylase Inhibitors Phase 1
40
Formaldehyde Approved, Vet_approved 50-00-0 712
41
Menthol Approved 2216-51-5 16666
42
Caffeine Approved, Nutraceutical 58-08-2 2519

Interventional clinical trials:

(show all 24)

id Name Status NCT ID Phase Drugs
1 Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis Completed NCT00033605 Phase 3 octreotide acetate
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms Active, not recruiting NCT01376349 Phase 3 prasterone
4 Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer Unknown status NCT00905658 Phase 2
5 Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer Completed NCT00381888 Phase 2 fondaparinux sodium
6 Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies Completed NCT01079832 Phase 2
7 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
8 Topotecan in Treating Patients With Gynecologic Cancer That Cannot Be Removed by Surgery Completed NCT00842452 Phase 1 topotecan hydrochloride
9 Docetaxel in Treating Patients With Refractory or Recurrent Advanced Gynecologic Cancer Completed NCT00287885 Phase 1 docetaxel
10 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
11 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
12 Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00083213 Phase 1
13 Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00082823 Phase 1
14 Chemotherapy Plus Radiation Therapy in Treating Patients With Unresectable, Residual, or Recurrent Colorectal Cancer Completed NCT00003704 Phase 1 capecitabine
15 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
16 Study of DNA Mutations in Predicting the Effect of External-Beam Radiation Therapy in Patients With Early Breast Cancer, Localized Prostate Cancer, or Gynecological Cancer Unknown status NCT00601406
17 A Survivorship Care Plan for Gynaecological Cancer Patients Unknown status NCT01582906
18 Study of Physical and Psychosocial Rehabilitation Needs of Patients After Diagnosis and Treatment of Upper Gastrointestinal Cancer or Gynecological Cancer Completed NCT01216813
19 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
20 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
21 Pelvic Floor Muscle Training in Treating Urinary Incontinence in Gynecologic Cancer Survivors Completed NCT01806350
22 Validation of a Nutrition Screening Tool Completed NCT01851928
23 Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic Cancer Completed NCT02096783
24 Specimen and Data Study for Ovarian Cancer Early Detection and Prevention Recruiting NCT00005095

Search NIH Clinical Center for Vulvar Sarcoma

Genetic Tests for Vulvar Sarcoma

Anatomical Context for Vulvar Sarcoma

MalaCards organs/tissues related to Vulvar Sarcoma:

39
Prostate, Liver

Publications for Vulvar Sarcoma

Articles related to Vulvar Sarcoma:

id Title Authors Year
1
A rare association between neurofibromatosis type 1 and vulvar sarcoma. ( 24819769 )
2014
2
Vulvar sarcoma: clinical implications. ( 7821491 )
1994
3
Vulvar sarcoma: a report of four cases. ( 1526519 )
1992

Variations for Vulvar Sarcoma

Expression for Vulvar Sarcoma

Search GEO for disease gene expression data for Vulvar Sarcoma.

Pathways for Vulvar Sarcoma

Pathways related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.17 EWSR1 H2AFX SMARCB1
2 10.88 CD34 PTPRC
3 10.64 AR TWIST1

GO Terms for Vulvar Sarcoma

Cellular components related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.8 AR H2AFX SMARCB1

Biological processes related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of tumor necrosis factor production GO:0032720 8.96 CD34 TWIST1
2 response to gamma radiation GO:0010332 8.62 GPX1 PTPRC

Sources for Vulvar Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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