MCID: VLV038
MIFTS: 25

Vulvar Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Vulvar Sarcoma

MalaCards integrated aliases for Vulvar Sarcoma:

Name: Vulvar Sarcoma 12 14
Sarcoma of Vulva 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2096
NCIt 46 C40317
SNOMED-CT 64 254897006
UMLS 69 C0238525

Summaries for Vulvar Sarcoma

MalaCards based summary : Vulvar Sarcoma, also known as sarcoma of vulva, is related to vulvar alveolar soft part sarcoma and extraosseous chondrosarcoma. An important gene associated with Vulvar Sarcoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and B Cell Development Pathways. Related phenotypes are cellular and hematopoietic system

Related Diseases for Vulvar Sarcoma

Diseases related to Vulvar Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 vulvar alveolar soft part sarcoma 11.1
2 extraosseous chondrosarcoma 10.4 EWSR1 SMARCB1
3 epithelial-myoepithelial carcinoma 10.3 KRT7 SMARCB1
4 epidural neoplasm 10.3 PTPRC SMARCB1
5 collecting duct carcinoma 10.3 KRT7 SMARCB1
6 atypical choroid plexus papilloma 10.3 KRT7 TWIST1
7 extraskeletal ewing sarcoma 10.3 EWSR1 PTPRC
8 bone epithelioid hemangioma 10.3 CD34 EWSR1
9 spindle cell liposarcoma 10.3 CD34 SMARCB1
10 chondrosarcoma, extraskeletal myxoid 10.3 EWSR1 SMARCB1
11 myoepithelioma 10.2 EWSR1 SMARCB1
12 olfactory neuroblastoma 10.2 EWSR1 PTPRC
13 mucinous cystadenocarcinoma 10.2 KRT7 PTPRC
14 epithelioid sarcoma 10.2 KRT7 SMARCB1
15 bone ewing's sarcoma 10.2 EWSR1 PTPRC
16 interstitial emphysema 10.2 CD34 TWIST1
17 oncocytic breast carcinoma 10.2 AR KRT7
18 apocrine adenocarcinoma 10.2 AR KRT7
19 immune system organ benign neoplasm 10.2 KRT7 PTPRC
20 thymus lipoma 10.2 KRT7 PTPRC
21 eccrine adenocarcinoma 10.2 CD34 KRT7
22 meibomian cyst 10.2 AR KRT7
23 corneal abscess 10.2 AR KRT7
24 extracutaneous mastocytoma 10.2 CD34 PTPRC
25 liver inflammatory pseudotumor 10.2 CD34 PTPRC
26 paget disease, extramammary 10.2 AR KRT7
27 glomeruloid hemangioma 10.2 CD34 PTPRC
28 diffuse cutaneous mastocytosis 10.2 CD34 PTPRC
29 sarcomatoid squamous cell skin carcinoma 10.2 CD34 PTPRC
30 chronic monocytic leukemia 10.2 CD34 PTPRC
31 infiltrative basal cell carcinoma 10.2 AR KRT7
32 skin sarcoma 10.2 CD34 EWSR1
33 conventional fibrosarcoma 10.2 CD34 PTPRC
34 kidney rhabdoid cancer 10.1 EWSR1 PTPRC SMARCB1
35 intraneural perineurioma 10.1 CD34 KRT7
36 rhabdoid cancer 10.1 EWSR1 PTPRC SMARCB1
37 reticulohistiocytic granuloma 10.1 CD34 PTPRC
38 cystitis cystica 10.1 AR KRT7
39 nephrogenic adenofibroma 10.1 CD34 KRT7
40 sweat gland cancer 10.1 AR KRT7
41 mesenchymal cell neoplasm 10.1 CD34 EWSR1 SMARCB1
42 muscle cancer 10.1 CD34 EWSR1
43 connective tissue cancer 10.0 CD34 EWSR1 SMARCB1
44 nervous system cancer 10.0 CD34 EWSR1 SMARCB1
45 desmoplastic small round cell tumor 10.0 EWSR1 PTPRC
46 spindle cell synovial sarcoma 10.0 CD34 KRT7 SMARCB1
47 organ system benign neoplasm 10.0 CD34 KRT7 SMARCB1
48 integumentary system benign neoplasm 10.0 CD34 EWSR1 KRT7
49 cell type cancer 10.0 CD34 EWSR1 KRT7
50 sarcoma 10.0

Graphical network of the top 20 diseases related to Vulvar Sarcoma:



Diseases related to Vulvar Sarcoma

Symptoms & Phenotypes for Vulvar Sarcoma

MGI Mouse Phenotypes related to Vulvar Sarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 H2AFX KRT7 PTPRC AR SMARCB1 CD34
2 hematopoietic system MP:0005397 9.8 H2AFX PTPRC AR SMARCB1 TCHP CD34
3 homeostasis/metabolism MP:0005376 9.76 H2AFX KRT7 PTPRC AR SMARCB1 TCHP
4 digestive/alimentary MP:0005381 9.72 PTPRC AR SMARCB1 TWIST1 GPX1
5 immune system MP:0005387 9.5 H2AFX PTPRC AR SMARCB1 TCHP CD34
6 neoplasm MP:0002006 9.02 H2AFX PTPRC AR SMARCB1 CD34

Drugs & Therapeutics for Vulvar Sarcoma

Search Clinical Trials , NIH Clinical Center for Vulvar Sarcoma

Genetic Tests for Vulvar Sarcoma

Anatomical Context for Vulvar Sarcoma

Publications for Vulvar Sarcoma

Articles related to Vulvar Sarcoma:

# Title Authors Year
1
A rare association between neurofibromatosis type 1 and vulvar sarcoma. ( 24819769 )
2014
2
Vulvar sarcoma: clinical implications. ( 7821491 )
1994
3
Vulvar sarcoma: a report of four cases. ( 1526519 )
1992

Variations for Vulvar Sarcoma

Expression for Vulvar Sarcoma

Search GEO for disease gene expression data for Vulvar Sarcoma.

Pathways for Vulvar Sarcoma

Pathways related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 AR EWSR1 H2AFX SMARCB1
2 10.88 CD34 PTPRC
3 10.64 AR TWIST1

GO Terms for Vulvar Sarcoma

Cellular components related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.13 AR H2AFX SMARCB1
2 XY body GO:0001741 8.62 H2AFX SMARCB1

Biological processes related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of tumor necrosis factor production GO:0032720 8.96 CD34 TWIST1
2 response to gamma radiation GO:0010332 8.62 GPX1 PTPRC

Molecular functions related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.8 AR CD34 TWIST1

Sources for Vulvar Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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