MCID: VLV042
MIFTS: 44

Vulvar Vestibulitis Syndrome

Categories: Rare diseases

Aliases & Classifications for Vulvar Vestibulitis Syndrome

MalaCards integrated aliases for Vulvar Vestibulitis Syndrome:

Name: Vulvar Vestibulitis Syndrome 49
Vulvar Dysesthesia Localized in the Vestibule 49
Vulvar Vestibulitis 69
Vvs 49

Classifications:



External Ids:

UMLS 69 C0269084

Summaries for Vulvar Vestibulitis Syndrome

MalaCards based summary : Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to vaginitis and vulvovaginal candidiasis. An important gene associated with Vulvar Vestibulitis Syndrome is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Prolactin Signaling Pathway. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain and testes, and related phenotypes are hematopoietic system and growth/size/body region

Wikipedia : 72 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

Related Diseases for Vulvar Vestibulitis Syndrome

Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 vaginitis 30.5 ESR1 IL1B
2 vulvovaginal candidiasis 29.5 IL1RN MBL2 NLRP3
3 syncope, familial vasovagal 12.0
4 vaccinia 11.3
5 prosthetic joint infection 10.4 IL1B MBL2
6 episodic pain syndrome, familial, 1 10.4
7 gastric cancer, hereditary diffuse 10.4 IL1B IL1RN
8 polyposis, gastric 10.3 IL1B TNF
9 systemic onset juvenile idiopathic arthritis 10.3 IL1B TNF
10 staphylococcal toxic shock syndrome 10.3 IL1B TNF
11 kashin-beck disease 10.3 IL1B TNF
12 hydrarthrosis 10.3 IL1B IL1RN
13 burns 10.3 IL1B TNF
14 laryngitis 10.3 IL1B TNF
15 haemophilus influenzae 10.3 IL1B TNF
16 retinitis pigmentosa 60 10.3 IL1B TNF
17 acute vascular insufficiency of intestine 10.3 IL1B TNF
18 actinic prurigo 10.3 IL1B TNF
19 poems syndrome 10.3 IL1B TNF
20 irritant dermatitis 10.3 IL1B TNF
21 crohn's colitis 10.3 IL1B TNF
22 adult dermatomyositis 10.3 MBL2 TNF
23 burning mouth syndrome 10.3 IL1B TNF
24 central nervous system vasculitis 10.3 IL1B TNF
25 dental pulp disease 10.3 IL1B TNF
26 stachybotrys chartarum 10.3 IL1B TNF
27 jejunoileitis 10.3 IL1B TNF
28 endometrial disease 10.3 ESR1 IL1B
29 root resorption 10.3 IL1B IL1RN
30 spondylosis 10.3 ESR1 IL1B
31 eales disease 10.3 IL1B TNF
32 paratyphoid fever 10.3 IL1R1 TNF
33 pulpitis 10.2 IL1B TNF
34 scrub typhus 10.2 IL1B TNF
35 listeriosis 10.2 MBL2 TNF
36 lacrimal apparatus disease 10.2 IL1B TNF
37 pleural disease 10.2 IL1B TNF
38 middle ear disease 10.2 IL1B TNF
39 scleral disease 10.2 IL1RN TNF
40 q fever 10.2 IL1B TNF
41 viral encephalitis 10.2 IL1B TNF
42 cellulitis 10.2 IL1R1 TNF
43 post-transplant lymphoproliferative disease 10.2 IL1R1 TNF
44 perinatal necrotizing enterocolitis 10.2 IL1B TNF
45 commensal bacterial infectious disease 10.2 IL1B TNF
46 palindromic rheumatism 10.2 IL1B TNF
47 pyoderma 10.2 IL1R1 TNF
48 sweat gland disease 10.2 IL1RN TNF
49 acute respiratory distress syndrome 10.2 IL1B TNF
50 periventricular leukomalacia 10.2 IL1R1 TNF

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to Vulvar Vestibulitis Syndrome

Symptoms & Phenotypes for Vulvar Vestibulitis Syndrome

MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IL1RN MBL2 ESR1 MC1R NLRP3 IL1B
2 growth/size/body region MP:0005378 9.95 IL1RN ESR1 MC1R NLRP3 IL1B TNF
3 homeostasis/metabolism MP:0005376 9.87 IL1R1 IL1RN MBL2 ESR1 NLRP3 IL1B
4 immune system MP:0005387 9.86 IL1RN MBL2 ESR1 MC1R NLRP3 IL1B
5 integument MP:0010771 9.7 IL1RN ESR1 MC1R NLRP3 IL1B TNF
6 neoplasm MP:0002006 9.35 ESR1 MC1R IL1B TNF IL1R1
7 skeleton MP:0005390 9.1 IL1RN ESR1 NLRP3 IL1B TNF IL1R1

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Drugs for Vulvar Vestibulitis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 1 137-58-6 3676
3 abobotulinumtoxinA Phase 4,Phase 3
4 Cholinergic Agents Phase 4,Phase 3,Phase 2
5 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
6 onabotulinumtoxinA Phase 4,Phase 3
7 Botulinum Toxins Phase 4,Phase 3,Phase 2
8 Botulinum Toxins, Type A Phase 4,Phase 3
9 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
10 Sodium Channel Blockers Phase 4,Phase 2,Phase 1
11 Anesthetics Phase 4,Phase 2,Phase 1
12 Anesthetics, Local Phase 4,Phase 2,Phase 1
13 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 1
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1
16
Nifedipine Approved Phase 3 21829-25-4 4485
17
Capsaicin Approved Phase 2, Phase 3,Phase 1 404-86-4 1548943
18
Milnacipran Approved, Investigational Phase 3 92623-85-3 65833
19 Tomato Approved, Nutraceutical Phase 3
20
Serotonin Phase 3 50-67-9 5202
21 calcium channel blockers Phase 3,Phase 2
22 Adrenergic Agents Phase 3
23 Serotonin Agents Phase 3
24 Serotonin Uptake Inhibitors Phase 3
25 Tocolytic Agents Phase 3
26 Neurotransmitter Uptake Inhibitors Phase 3
27 Vasodilator Agents Phase 3
28 Dermatologic Agents Phase 2, Phase 3,Phase 1
29 Antidepressive Agents Phase 3
30 Psychotropic Drugs Phase 3,Phase 2
31 Antipruritics Phase 2, Phase 3,Phase 1
32 Calcium, Dietary Phase 3,Phase 2
33 Neuromuscular Agents Phase 3
34 Pharmaceutical Solutions Phase 3
35
Heparin Approved, Investigational Phase 2 9005-49-6 46507594 772
36
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
37
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
38
Promethazine Approved, Investigational Phase 2 60-87-7 4927
39
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
40
Petrolatum Approved, Investigational Phase 2 8009-03-8
41
Histamine Phosphate Phase 2 51-74-1 65513
42 Gastrointestinal Agents Phase 2
43 Histamine Antagonists Phase 2
44 Histamine H1 Antagonists Phase 2
45 Anti-Allergic Agents Phase 2
46 Hypnotics and Sedatives Phase 2
47 Antiemetics Phase 2
48 Autonomic Agents Phase 2
49 Analgesics Phase 2
50 Tranquilizing Agents Phase 2

Interventional clinical trials:

(show all 43)

# Name Status NCT ID Phase Drugs
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
2 Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia Recruiting NCT01935063 Phase 4
3 Dysbiosis in Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
4 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
5 Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis Completed NCT00496184 Phase 3 Nifedipine cream topical application
6 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Recruiting NCT02858219 Phase 3 Botulinum Toxin Type A
7 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Recruiting NCT02854670 Phase 2, Phase 3 Capsaicin patch
8 Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Not yet recruiting NCT02773641 Phase 3 Botulinum Toxin Type A;Placebo
9 Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia Unknown status NCT01747161 Phase 2 Botulin toxin;physiological water
10 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
11 Enoxaparin as Treatment for Vulvodynia Completed NCT00874484 Phase 2 Clexane (enoxaparin)
12 Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort Completed NCT00590590 Phase 2 Lidocaine/Diphenhydramine;lidocaine;placebo
13 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis Terminated NCT00450242 Phase 2 5% topical lidocaine ointment;Placebo cream
14 Pregabalin for the Treatment of Vulvodynia Terminated NCT00853229 Phase 2 pregabalin
15 Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study Completed NCT01996384 Phase 1 Lidocaine
16 Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia Completed NCT02494934
17 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Completed NCT01704456
18 Integrated Mindfulness for Provoked Vestibulodynia Completed NCT01704443
19 The Use of Acupuncture for the Treatment of Vulvar Vestibulitis Completed NCT02362763
20 Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia Completed NCT01455350 lidocaine
21 Pilot Study to Assess the Efficacy of Cognitive-behavioral Couple Therapy for Provoked Vestibulodynia Completed NCT01582373
22 Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine Completed NCT00276068 topical lidocaine + oral desipramine, and/or placebo
23 Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia Completed NCT02858375
24 Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Completed NCT02543593
25 "Vestibulitis Educational Seminar Trial" Study Completed NCT00278850
26 A Search for Helicobacter Pylori in Localized Vulvodynia Completed NCT00501774
27 Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Completed NCT01731288
28 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
29 Acupuncture for the Treatment of Vulvodynia Completed NCT02197429
30 Acupuncture for Vulvodynia: A Pre-pilot Study Completed NCT02704234
31 Outcomes of Delivery in Patients With Dyspareunia Completed NCT01753258
32 The Effectiveness of Vestibulectomy Completed NCT00873301
33 Physiotherapy Intervention for Provoked Vulvar Vestibulodynia Recruiting NCT01628679
34 Lipofilling as a Treatment for Vestibulodynia Recruiting NCT03431779
35 Subtypes of Provoked Vestibulodynia Recruiting NCT02712814 Topical hormonal cream (estrogen)
36 The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia Recruiting NCT02892214 estriol cream (ovestin)
37 Effect of Acupuncture on Patient Vulvodynia Outcomes Recruiting NCT03364127
38 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
39 Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia Terminated NCT01149031
40 Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Terminated NCT02204319
41 Study of Emu Oil vs. Placebo for Vulvar Pain in Women. Terminated NCT01295268
42 Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia Withdrawn NCT01741948 Hormonal contraceptive
43 Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia Withdrawn NCT03390049

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

38
Brain, Testes

Publications for Vulvar Vestibulitis Syndrome

Articles related to Vulvar Vestibulitis Syndrome:

(show top 50) (show all 82)
# Title Authors Year
1
The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome. ( 24961922 )
2014
2
Elevated tissue levels of tumor necrosis factor-I+ in vulvar vestibulitis syndrome. ( 25551965 )
2014
3
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. ( 20168100 )
2009
4
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. ( 19622972 )
2009
5
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. ( 19254587 )
2009
6
Overlap between orofacial pain and vulvar vestibulitis syndrome. ( 18287822 )
2008
7
Somatization and psychological distress among women with vulvar vestibulitis syndrome. ( 18635182 )
2008
8
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. ( 17936236 )
2008
9
Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism. ( 18166320 )
2008
10
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. ( 17136588 )
2007
11
Human papillomavirus in vulvar vestibulitis syndrome. ( 17694965 )
2007
12
Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. ( 17367437 )
2007
13
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. ( 17970976 )
2007
14
Vulvar vestibulitis syndrome. ( 17064641 )
2006
15
Surgical treatment of vulvar vestibulitis syndrome: outcome assessment derived from a postoperative questionnaire. ( 16942537 )
2006
16
A cognitive-behavioral group program for women with vulvar vestibulitis syndrome (VVS): factors associated with treatment success. ( 16809249 )
2006
17
Surgical treatment for the vulvar vestibulitis syndrome. ( 16449109 )
2006
18
Hyperoxaluria in women with vulvar vestibulitis syndrome. ( 16846091 )
2006
19
A conceptual model for the pathophysiology of vulvar vestibulitis syndrome. ( 16719941 )
2006
20
Surgical techniques: Surgery for Vulvar Vestibulitis syndrome. ( 16681483 )
2006
21
Tender point examination in women with vulvar vestibulitis syndrome. ( 16926575 )
2006
22
Vulvar vestibulitis syndrome: an important factor in the evaluation of lifelong vaginismus? ( 16457419 )
2005
23
The major histopathologic characteristics in the vulvar vestibulitis syndrome. ( 15542936 )
2005
24
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. ( 15836975 )
2005
25
Vulvar vestibulitis syndrome: a review. ( 15927350 )
2005
26
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. ( 16050536 )
2005
27
Psychological aspects of vulvar vestibulitis syndrome. ( 16050535 )
2005
28
Psychological factors associated with perception of experimental pain in vulvar vestibulitis syndrome. ( 16020147 )
2005
29
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. ( 15772910 )
2005
30
To cut or not to cut: treatment of vulvar vestibulitis syndrome. ( 15376407 )
2004
31
Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms. ( 15041996 )
2004
32
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. ( 15305821 )
2004
33
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. ( 15467537 )
2004
34
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. ( 15295354 )
2004
35
Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative? ( 15775875 )
2004
36
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. ( 15162345 )
2004
37
A new instrument for pain assessment in vulvar vestibulitis syndrome. ( 15043051 )
2004
38
Vulvar vestibulitis syndrome: a clinical approach. ( 15205070 )
2004
39
Estrogen receptor expression in vulvar vestibulitis syndrome. ( 14520218 )
2003
40
Hypnotherapy as a treatment for vulvar vestibulitis syndrome: a case report. ( 12851128 )
2003
41
Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. ( 14584306 )
2003
42
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. ( 12593899 )
2003
43
In favor of an integrated pain-relief treatment approach for vulvar vestibulitis syndrome. ( 12061041 )
2002
44
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome. ( 11967493 )
2002
45
Web-enabled Glazer surface electromyographic protocol for the remote, real-time assessment and rehabilitation of pelvic floor dysfunction in vulvar vestibulitis syndrome. A case report. ( 12380455 )
2002
46
Physical therapy for vulvar vestibulitis syndrome: a retrospective study. ( 11995597 )
2002
47
Differential characterization of women with vulvar vestibulitis syndrome. ( 12237632 )
2002
48
Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome. ( 11932072 )
2002
49
Vulvar vestibulitis syndrome: care made to measure. ( 12061037 )
2002
50
Vulvar vestibulitis syndrome: an overview of non-surgical treatment. ( 11858882 )
2002

Variations for Vulvar Vestibulitis Syndrome

Expression for Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for Vulvar Vestibulitis Syndrome

Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 IL1B IL1R1 IL1RN NLRP3 TNF
2
Show member pathways
12.26 ESR1 IL1B IL1RN
3
Show member pathways
12.07 IL1B IL1R1 IL1RN
4
Show member pathways
12.03 IL1B IL1R1 TNF
5
Show member pathways
11.99 IL1B NLRP3 TNF
6
Show member pathways
11.94 IL1B IL1R1 TNF
7 11.92 IL1B IL1RN TNF
8 11.83 IL1B IL1R1 TNF
9 11.78 IL1B IL1R1 TNF
10 11.73 IL1B IL1R1 TNF
11 11.62 IL1B IL1R1 TNF
12 11.59 IL1B IL1R1 TNF
13 11.56 IL1B IL1R1 TNF
14 11.45 IL1B IL1R1 TNF
15 11.38 IL1B NLRP3 TNF
16 11.34 IL1B TNF
17 11.33 ESR1 TNF
18 11.32 IL1B TNF
19 11.32 IL1B TNF
20 11.29 IL1B TNF
21 11.24 IL1B NLRP3
22 11.16 IL1B TNF
23 11.16 IL1B TNF
24 11.11 IL1B TNF
25 11.09 IL1B TNF
26 11.07 IL1B TNF
27
Show member pathways
10.97 IL1B IL1R1 TNF
28 10.92 IL1B TNF
29 10.73 IL1B TNF
30 10.61 IL1B IL1R1 IL1RN TNF
31 10.53 IL1B IL1R1 NLRP3

GO Terms for Vulvar Vestibulitis Syndrome

Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 IL1B IL1R1 IL1RN MBL2 NLRP3 TNF

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 ESR1 IL1B MC1R NLRP3 TNF
2 immune response GO:0006955 9.88 IL1B IL1R1 IL1RN TNF
3 inflammatory response GO:0006954 9.8 IL1B IL1RN NLRP3 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.74 IL1B NLRP3 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.69 ESR1 IL1B TNF
6 defense response to Gram-positive bacterium GO:0050830 9.65 MBL2 NLRP3 TNF
7 positive regulation of interleukin-6 production GO:0032755 9.64 IL1B TNF
8 protein kinase B signaling GO:0043491 9.64 IL1B TNF
9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.63 NLRP3 TNF
10 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B TNF
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL1B TNF
12 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.62 IL1B TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 IL1B TNF
14 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B TNF
15 positive regulation of NF-kappaB import into nucleus GO:0042346 9.6 IL1B TNF
16 negative regulation of lipid catabolic process GO:0050995 9.59 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IL1B TNF
18 negative regulation of growth of symbiont in host GO:0044130 9.56 MBL2 TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.55 IL1B TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL1B TNF
21 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
22 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
23 interleukin-1 beta production GO:0032611 9.4 IL1B NLRP3
24 fever generation GO:0001660 9.37 IL1B IL1RN
25 positive regulation of fever generation GO:0031622 9.32 IL1B TNF
26 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
28 positive regulation of phagocytosis GO:0050766 9.13 IL1B MBL2 TNF
29 regulation of inflammatory response GO:0050727 8.92 ESR1 IL1R1 NLRP3 TNF

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1RN TNF
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Vulvar Vestibulitis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
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53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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