VVS
MCID: VLV042
MIFTS: 47

Vulvar Vestibulitis Syndrome (VVS) malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Vulvar Vestibulitis Syndrome

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66Wikipedia, 34MalaCards
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Wikipedia:66 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

MalaCards: Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to vaccinia and urethritis. An important gene associated with Vulvar Vestibulitis Syndrome is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are TRAF Pathway and Th17 Differentiation. The compounds zymosan and adalimumab have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Aliases & Classifications for Vulvar Vestibulitis Syndrome

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63UMLS, 44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

vulvar vestibulitis syndrome 44
vulvar dysesthesia localized in the vestibule 44
familial neurocardiogenic syncope 63
vvs 44


Related Diseases for Vulvar Vestibulitis Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1vaccinia10.4
2urethritis10.2
3vulvovaginitis10.2
4vulvovaginal candidiasis10.2
5candidiasis10.2
6psychosexual disorder10.2
7molluscum contagiosum10.2
8hiv-110.2
9pyoderma gangrenosum10.1NLRP3
10malaria10.1TNF
11dengue shock syndrome10.1IL1RN
12gastric cancer risk after h. pylori infection10.1IL1RN
13hyper-igd syndrome10.1IL1RN
14degenerative disc disease10.1IL1B
15periodontal disease10.1TNF
16periodontitis10.1IL1B
17skin disease10.1IL1B
18aseptic meningitis10.1NLRP3, IL1R1
19schnitzler syndrome10.1IL1R1, IL1RN
20familial mediterranean fever10.1NLRP3, TNF
21exanthem10.1IL1RN, NLRP3
22alopecia areata10.0IL1R1, IL1RN
23behcet's disease10.0TNF, MBL2
24adult respiratory distress syndrome10.0IL1R1, TNF
25otitis media10.0IL1B, MBL2
26interstitial lung disease10.0IL1R1, IL1RN
27iga glomerulonephritis10.0IL1R1, MBL2
28gout10.0NLRP3, IL1B
29shigellosis10.0IL1R1, IL1B
30meningitis10.0MBL2, IL1B
31graft versus host disease10.0IL1R1, TNF
32aids dementia complex10.0TNF, IL1B
33arthritis10.0TNF, IL1B
34psoriatic arthritis10.0TNF, IL1B
35uveitis10.0TNF, IL1R1
36respiratory failure10.0IL1B, TNF
37newborn respiratory distress syndrome10.0IL1RN, IL1B
38neisseria meningitidis infection10.0IL1R1, IL1RN, MBL2
39acute pancreatitis10.0IL1RN, IL1R1
40vasculitis10.0MBL2, TNF
41peritonitis10.0TNF, IL1B
42nephritis10.0IL1RN, IL1R1
43bacterial vaginosis10.0IL1R1, IL1B, MBL2
44familial cold autoinflammatory syndrome10.0IL1R1, IL1B, NLRP3
45osteoporosis, postmenopausal10.0IL1RN, ESR1
46muckle-wells syndrome10.0IL1R1, IL1B, NLRP3
47acute graft versus host disease10.0IL1RN, IL1R1, TNF
48juvenile rheumatoid arthritis10.0TNF, IL1R1, IL1RN
49ankylosing spondylitis10.0TNF, IL1R1, IL1RN
50rheumatic disease10.0TNF, IL1R1, IL1RN

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to vulvar vestibulitis syndrome

Symptoms for Vulvar Vestibulitis Syndrome

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Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vulvar Vestibulitis Syndrome

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Anatomical Context for Vulvar Vestibulitis Syndrome

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34MalaCards
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MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

34
Testes

Animal Models for Vulvar Vestibulitis Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5TNF, MC1R, ESR1, NLRP3
2MP:00053708.2NLRP3, IL1R1, ESR1, TNF
3MP:00053678.1ESR1, IL1R1, NLRP3, MBL2
4MP:00020067.9TNF, MC1R, ESR1, IL1R1, IL1B
5MP:00036317.6NLRP3, IL1B, IL1R1, ESR1, TNF
6MP:00107717.6TNF, MC1R, ESR1, IL1R1, IL1RN, NLRP3
7MP:00053857.6TNF, ESR1, IL1R1, IL1RN, IL1B
8MP:00053847.5TNF, MC1R, ESR1, IL1R1, IL1RN, NLRP3
9MP:00053787.5TNF, MC1R, ESR1, IL1R1, IL1RN, NLRP3
10MP:00053907.4TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3
11MP:00107687.1TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3
12MP:00053977.1MBL2, TNF, ESR1, IL1R1, IL1RN, IL1B
13MP:00053877.0TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3
14MP:00053767.0TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3

Publications for Vulvar Vestibulitis Syndrome

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53PubMed
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Articles related to Vulvar Vestibulitis Syndrome:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. (19254587)
2009
2
Overlap between orofacial pain and vulvar vestibulitis syndrome. (18287822)
2008
3
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. (17136588)
2007
4
A cognitive-behavioral group program for women with vulvar vestibulitis syndrome (VVS): factors associated with treatment success. (16809249)
2006
5
Surgical treatment for the vulvar vestibulitis syndrome. (16449109)
2006
6
Hyperoxaluria in women with vulvar vestibulitis syndrome. (16846091)
2006
7
A conceptual model for the pathophysiology of vulvar vestibulitis syndrome. (16719941)
2006
8
Psychological factors associated with perception of experimental pain in vulvar vestibulitis syndrome. (16020147)
2005
9
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. (15772910)
2005
10
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. (15836975)
2005
11
Vulvar vestibulitis syndrome: a review. (15927350)
2005
12
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. (16050536)
2005
13
The major histopathologic characteristics in the vulvar vestibulitis syndrome. (15542936)
2005
14
Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms. (15041996)
2004
15
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. (15305821)
2004
16
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. (15162345)
2004
17
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. (15295354)
2004
18
Vulvar vestibulitis syndrome: a clinical approach. (15205070)
2004
19
To cut or not to cut: treatment of vulvar vestibulitis syndrome. (15376407)
2004
20
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. (15467537)
2004
21
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. (12593899)
2003
22
Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. (14584306)
2003
23
Differential characterization of women with vulvar vestibulitis syndrome. (12237632)
2002
24
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome. (11967493)
2002
25
Web-enabled Glazer surface electromyographic protocol for the remote, real-time assessment and rehabilitation of pelvic floor dysfunction in vulvar vestibulitis syndrome. A case report. (12380455)
2002
26
Vulvar vestibulitis syndrome: care made to measure. (12061037)
2002
27
Combined vulvar vestibulitis syndrome with vaginismus: which to treat first? (11554214)
2001
28
A review of physical and psychological factors in vulvar vestibulitis syndrome. (11589808)
2001
29
Psychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndrome. (11690731)
2001
30
Vulvar vestibulitis syndrome: reliability of diagnosis and evaluation of current diagnostic criteria. (11430955)
2001
31
Vulvar vestibulitis syndrome (VVS) is not primarily a psychosexual disorder. (10870796)
2000
32
Vulvar vestibulitis syndrome and vaginismus. A case report. (10756500)
2000
33
Vulvar Vestibulitis Syndrome: A Post-infectious Entity? (11095904)
2000
34
Vulvar vestibulitis syndrome. (10554969)
1999
35
Human papillomavirus with co-existing vulvar vestibulitis syndrome and vestibular papillomatosis. (10366048)
1999
36
Vulvar vestibulitis syndrome: an often unrecognized cause of dyspareunia. (10099756)
1999
37
Increased intraepithelial innervation in women with vulvar vestibulitis syndrome. (9813445)
1998
38
Polymerase chain reaction search for viral etiology of vulvar vestibulitis syndrome. (8694039)
1996
39
Behavioral approach with or without surgical intervention to the vulvar vestibulitis syndrome: a prospective randomized and non-randomized study. (8892160)
1996
40
Treatment of vulvar vestibulitis syndrome with electromyographic biofeedback of pelvic floor musculature. (7623358)
1995
41
Vulvar vestibulitis syndrome: an exploratory case-control study. (8272306)
1994
42
Vaginismus: an important factor in the evaluation and management of vulvar vestibulitis syndrome. (8001875)
1994
43
Intralesional alpha interferon. Cost-effective therapy for vulvar vestibulitis syndrome. (8382744)
1993
44
Urethral pressure variation in women with vulvar vestibulitis syndrome. (8333432)
1993
45
Antitrichomonal (cross) immunity as an important factor in vulvar vestibulitis syndrome pathogenesis. (1607200)
1992
46
Vulvar vestibulitis syndrome. (1606769)
1992
47
Vulvar vestibulitis syndrome: an overview. (1659198)
1991
48
Vulvar vestibulitis syndrome: a clinico-pathological study. (1883796)
1991
49
Association of human papillomavirus with vulvodynia and the vulvar vestibulitis syndrome. (2841460)
1988
50
Vulvar vestibulitis syndrome. (3560069)
1987

Variations for Vulvar Vestibulitis Syndrome

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Expression for genes affiliated with Vulvar Vestibulitis Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for genes affiliated with Vulvar Vestibulitis Syndrome

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Sources:
51PathCards, 54QIAGEN, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome
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Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TNF
2
Show member pathways
9.4IL1B, IL1R1
3
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.4IL1B, IL1R1
49.3TNF, IL1B
59.3TNF, IL1B
69.3TNF, IL1B
79.3TNF, IL1B
89.3TNF, IL1B
99.3TNF, IL1B
109.3TNF, IL1B
11
Show member pathways
IL27-mediated signaling events39
9.3TNF, IL1B
129.3IL1B, TNF
139.3IL1B, TNF
149.3IL1B, TNF
158.9TNF, IL1B, NLRP3
16
Show member pathways
8.9TNF, IL1B, NLRP3
17
Show member pathways
8.9NLRP3, IL1B, TNF
18
Show member pathways
8.9IL1B, IL1RN, IL1R1
19
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
8.9IL1B, IL1RN, IL1R1
20
Show member pathways
8.9IL1B, IL1RN, IL1R1
21
Show member pathways
Serotonin Transporter Activity39
8.9TNF, IL1R1, IL1B
228.9TNF, IL1R1, IL1B
23
Show member pathways
8.9TNF, IL1R1, IL1B
24
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.9TNF, IL1R1, IL1B
25
Show member pathways
Immune response MIF in innate immunity response61
8.9TNF, IL1R1, IL1B
268.9TNF, IL1R1, IL1B
27
Show member pathways
8.9TNF, IL1R1, IL1B
28
Show member pathways
8.9TNF, IL1R1, IL1B
29
Show member pathways
8.9IL1B, IL1R1, TNF
308.9IL1B, IL1R1, TNF
31
Show member pathways
MAPK signaling pathway39
8.9IL1B, IL1R1, TNF
328.9IL1B, IL1R1, TNF
338.9IL1B, IL1R1, TNF
348.8IL1B, IL1RN, TNF
358.7IL1R1, ESR1, TNF
36
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.6IL1B, IL1R1, ESR1
37
Show member pathways
8.1TNF, ESR1, IL1R1, IL1B
38
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
7.9NLRP3, IL1B, IL1RN, IL1R1, TNF

Compounds for genes affiliated with Vulvar Vestibulitis Syndrome

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1zymosan469.5IL1RN, MBL2, TNF
2adalimumab46 52 1211.4IL1R1, TNF, IL1RN
3tenidap46 3010.3IL1B, TNF, IL1R1
4il-12469.3TNF, IL1R1, IL1B
5cuprophan469.2IL1R1, IL1RN, IL1B
6polysulfone469.2IL1R1, IL1B, IL1RN
7toxin-1469.2TNF, IL1RN, IL1B
8p003469.2MBL2, IL1RN, IL1R1
9diphenyleneiodonium469.1TNF, IL1R1, IL1B
10ns 39846 6210.1TNF, IL1RN, IL1B
11ccl346 3010.1IL1B, TNF, IL1R1
12ibuprofen46 30 52 25 1213.1IL1B, IL1R1, IL1RN
13l-nmma469.1TNF, IL1RN, IL1B
14chloroquine46 3 52 30 1213.1IL1R1, IL1RN, TNF
15thalidomide46 52 62 1212.0TNF, IL1R1, IL1B
16prednisolone46 30 1211.0IL1RN, IL1R1, MBL2, TNF
17polymyxin b468.9MBL2, IL1B, IL1RN, TNF
18fibrinogen468.9IL1R1, TNF, MBL2, IL1RN
19corticosterone46 62 2510.9IL1B, IL1R1, IL1RN
20acth468.8IL1R1, IL1B, IL1RN, MC1R
21gold sodium thiomalate468.8IL1RN, TNF, IL1R1, IL1B
22sulfasalazine30 46 52 1211.8IL1RN, IL1R1, TNF, IL1B
23etanercept46 52 1210.8IL1R1, IL1RN, TNF, IL1B
24il 10468.8IL1R1, IL1B, IL1RN, TNF
25infliximab46 52 1210.8TNF, IL1RN, IL1B, IL1R1
26ivig468.8IL1RN, IL1R1, IL1B, TNF
27pentoxifylline46 129.8IL1RN, TNF, IL1R1, IL1B
28leukotriene b446 62 2510.8TNF, IL1R1, IL1B, IL1RN
29hydrocortisone46 3 62 1211.7IL1B, IL1RN, IL1R1, TNF
30endotoxin468.7IL1B, IL1RN, IL1R1, TNF
31prostaglandin468.7IL1RN, IL1R1, TNF, IL1B
32indomethacin46 30 62 1211.7TNF, IL1R1, IL1RN, IL1B
33sb 20358046 629.7IL1RN, IL1R1, IL1B, TNF
34mifepristone46 30 62 1211.5ESR1, IL1R1, IL1B
35lipoteichoic acid468.5IL1R1, MBL2, IL1B, TNF, IL1RN
36peptidoglycan46 309.5MBL2, IL1B, TNF, IL1RN, IL1R1
37neopterin468.4TNF, IL1RN, MBL2, IL1B, IL1R1
38rantes468.4IL1R1, TNF, IL1RN, IL1B, MBL2
39pge2468.4IL1R1, IL1RN, IL1B, TNF
40anakinra46 129.4IL1RN, NLRP3, IL1B, IL1R1, TNF
41vitamin d468.4ESR1, IL1R1, MC1R, MBL2, IL1RN
42dexamethasone46 52 30 1211.3IL1B, IL1RN, TNF, IL1R1, MBL2
43nitric oxide46 25 1210.3TNF, IL1B, MBL2, IL1RN, IL1R1
44actinomycin d468.3IL1R1, ESR1, TNF, IL1B
45superoxide46 259.2TNF, IL1RN, IL1B, MBL2
46leflunomide46 52 1210.0ESR1, IL1R1, IL1RN, IL1B, TNF
47cycloheximide467.9ESR1, IL1B, IL1RN, IL1R1, TNF
48retinoic acid46 258.7ESR1, IL1R1, IL1RN, IL1B, TNF
49vegf467.6TNF, MBL2, IL1R1, IL1RN, ESR1, IL1B
50methotrexate52 46 129.6TNF, NLRP3, IL1B, IL1RN, IL1R1, ESR1

GO Terms for genes affiliated with Vulvar Vestibulitis Syndrome

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17Gene Ontology
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Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9TNF, IL1R1, MBL2
2extracellular regionGO:0055768.5MBL2, IL1B, IL1R1, TNF
3extracellular spaceGO:0056158.4MBL2, IL1B, IL1RN, TNF

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.0TNF, MBL2
2defense response to Gram-positive bacteriumGO:0508309.9TNF, MBL2
3chronic inflammatory response to antigenic stimulusGO:0024399.8IL1RN, TNF
4interleukin-1 beta productionGO:0326119.8IL1B, NLRP3
5acute-phase responseGO:0069539.8IL1RN, MBL2
6positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.8TNF, NLRP3
7positive regulation of JUN kinase activityGO:0435079.8TNF, IL1RN
8positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IL1B
9sequestering of triglycerideGO:0307309.7TNF, IL1B
10fever generationGO:0016609.7IL1RN, IL1B
11positive regulation of heterotypic cell-cell adhesionGO:0341169.7TNF, IL1B
12positive regulation of fever generationGO:0316229.7TNF, IL1B
13positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IL1B
14regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.7TNF, IL1B
15positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IL1B, TNF
16negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
17positive regulation of NF-kappaB import into nucleusGO:0423469.7IL1B, TNF
18lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
19positive regulation of mitosisGO:0458409.7IL1B, TNF
20positive regulation of protein kinase B signalingGO:0518979.6MC1R, TNF
21protein kinase B signalingGO:0434919.6TNF, IL1B
22negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
23cellular response to organic cyclic compoundGO:0714079.6TNF, IL1B
24positive regulation of interferon-gamma productionGO:0327299.6TNF, IL1B
25positive regulation of interleukin-6 productionGO:0327559.5IL1B, TNF
26positive regulation of JNK cascadeGO:0463309.5IL1B, TNF
27MAPK cascadeGO:0001659.4TNF, IL1B
28response to glucocorticoidGO:0513849.4TNF, IL1RN
29regulation of insulin secretionGO:0507969.3IL1B, TNF
30positive regulation of NF-kappaB transcription factor activityGO:0510929.3NLRP3, IL1B, TNF
31activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.2NLRP3, TNF
32inflammatory responseGO:0069549.2NLRP3, IL1B, TNF
33immune responseGO:0069559.1IL1R1, IL1RN, IL1B
34negative regulation of gene expressionGO:0106299.0TNF, ESR1
35positive regulation of nitric oxide biosynthetic processGO:0454298.9IL1B, ESR1, TNF
36positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL1B, ESR1, TNF
37positive regulation of transcription from RNA polymerase II promoterGO:0459448.5IL1B, ESR1, MC1R, TNF

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5IL1R1, TNF
2interleukin-1 receptor bindingGO:0051499.0IL1B, IL1RN

Products for genes affiliated with Vulvar Vestibulitis Syndrome

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Sources for Vulvar Vestibulitis Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet