VVS
MCID: VLV042
MIFTS: 37

Vulvar Vestibulitis Syndrome (VVS) malady

Neuronal, Genetic categories

Summaries for Vulvar Vestibulitis Syndrome

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64Wikipedia, 33MalaCards
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Wikipedia:64 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

MalaCards: Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to n syndrome and char syndrome. An important gene associated with Vulvar Vestibulitis Syndrome is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)), and among its related pathways are MAPK signaling pathway and Monoamine Transport. The compounds tenidap and cuprophan have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and tumorigenesis.

Aliases & Classifications for Vulvar Vestibulitis Syndrome

Sources:
61UMLS, 43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal


Aliases & Descriptions:

vulvar vestibulitis syndrome 43
vulvar dysesthesia localized in the vestibule 43
familial neurocardiogenic syncope 61
vvs 43


Related Diseases for Vulvar Vestibulitis Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to vulvar vestibulitis syndrome

Clinical Features for Vulvar Vestibulitis Syndrome

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Vulvar Vestibulitis Syndrome

Drug clinical trials:

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Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Search CenterWatch for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

Animal Models for Vulvar Vestibulitis Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.6IL1B
2MP:00020068.6TNF, MC1R, IL1R1, IL1B
3MP:00107717.5NLRP3, TNF, MC1R, IL1RN, IL1R1, ESR1
4MP:00053787.4TNF, MC1R, IL1RN, IL1R1, ESR1, NLRP3
5MP:00053977.3NLRP3, MBL2, TNF, IL1RN, IL1R1, ESR1
6MP:00053876.9ESR1, NLRP3, MBL2, TNF, IL1RN, IL1R1
7MP:00053766.7NLRP3, MBL2, TNF, IL1RN, IL1R1, IL1B

Publications for Vulvar Vestibulitis Syndrome

Sources:
51PubMed
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Articles related to Vulvar Vestibulitis Syndrome:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. (20168100)
2009
2
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. (19622972)
2009
3
Overlap between orofacial pain and vulvar vestibulitis syndrome. (18287822)
2008
4
Somatization and psychological distress among women with vulvar vestibulitis syndrome. (18635182)
2008
5
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. (17936236)
2008
6
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. (17136588)
2007
7
Human papillomavirus in vulvar vestibulitis syndrome. (17694965)
2007
8
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. (17970976)
2007
9
Surgical treatment for the vulvar vestibulitis syndrome. (16449109)
2006
10
Vulvar vestibulitis syndrome. (17064641)
2006
11
Surgical techniques: Surgery for Vulvar Vestibulitis syndrome. (16681483)
2006
12
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. (15772910)
2005
13
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. (16050536)
2005
14
The major histopathologic characteristics in the vulvar vestibulitis syndrome. (15542936)
2005
15
Psychological aspects of vulvar vestibulitis syndrome. (16050535)
2005
16
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. (15305821)
2004
17
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. (15162345)
2004
18
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. (15295354)
2004
19
Vulvar vestibulitis syndrome: a clinical approach. (15205070)
2004
20
To cut or not to cut: treatment of vulvar vestibulitis syndrome. (15376407)
2004
21
A new instrument for pain assessment in vulvar vestibulitis syndrome. (15043051)
2004
22
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. (12593899)
2003
23
Vulvar vestibulitis syndrome: care made to measure. (12061037)
2002
24
Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome. (11932072)
2002
25
Vulvar vestibulitis syndrome: an overview of non-surgical treatment. (11858882)
2002
26
Physical therapy for vulvar vestibulitis syndrome: a retrospective study. (11995597)
2002
27
Combined vulvar vestibulitis syndrome with vaginismus: which to treat first? (11554214)
2001
28
A review of physical and psychological factors in vulvar vestibulitis syndrome. (11589808)
2001
29
Vulvar vestibulitis syndrome and vaginismus. A case report. (10756500)
2000
30
Vulvar Vestibulitis Syndrome: A Post-infectious Entity? (11095904)
2000
31
Vulvar vestibulitis syndrome. (10554969)
1999
32
Human papillomavirus with co-existing vulvar vestibulitis syndrome and vestibular papillomatosis. (10366048)
1999
33
Vulvar vestibulitis syndrome: an often unrecognized cause of dyspareunia. (10099756)
1999
34
Epidemiology of vulvar vestibulitis syndrome: an exploratory case-control study. (10616356)
1999
35
Assessment of response to treatment in vulvar vestibulitis syndrome by means of the vulvar algesiometer. (10411802)
1999
36
Vulvar vestibulitis syndrome: a descriptive study and assessment of response to local steroid and topical clindamycin treatment. (15512220)
1999
37
Vestibular nerve fiber proliferation in vulvar vestibulitis syndrome. (9540943)
1998
38
Sexual behavior changes with vulvar vestibulitis syndrome. (9777617)
1998
39
Vulvar vestibulitis syndrome: a critical review. (9084950)
1997
40
Polymerase chain reaction search for viral etiology of vulvar vestibulitis syndrome. (8694039)
1996
41
Behavioral approach with or without surgical intervention to the vulvar vestibulitis syndrome: a prospective randomized and non-randomized study. (8892160)
1996
42
Vulvar vestibulitis syndrome: an exploratory case-control study. (8272306)
1994
43
Intralesional alpha interferon. Cost-effective therapy for vulvar vestibulitis syndrome. (8382744)
1993
44
Antitrichomonal (cross) immunity as an important factor in vulvar vestibulitis syndrome pathogenesis. (1607200)
1992
45
Vulvar vestibulitis syndrome. (1606769)
1992
46
Vulvar vestibulitis syndrome. (1472890)
1992
47
Vulvar vestibulitis syndrome: an overview. (1659198)
1991
48
Vulvar vestibulitis syndrome: a clinico-pathological study. (1883796)
1991
49
The histopathology of vulvar vestibulitis syndrome. (2460413)
1988
50
Vulvar vestibulitis syndrome. (3560069)
1987

Genetic Variations for Vulvar Vestibulitis Syndrome

Expression for genes affiliated with Vulvar Vestibulitis Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for genes affiliated with Vulvar Vestibulitis Syndrome

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore, 53R&D Systems
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Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1IL1R1
210.1IL1R1
3
Hide members
9.4IL1R1, IL1B
49.3TNF, IL1B
59.3TNF, IL1B
69.3TNF, IL1B
79.3IL1B, TNF
89.3IL1B, TNF
9
Hide members
8.9IL1RN, IL1R1, IL1B
10
Hide members
8.9IL1B, IL1R1, IL1RN
11
Hide members
8.9IL1B, IL1R1, IL1RN
12
Hide members
8.9TNF, IL1R1, IL1B
138.9TNF, IL1R1, IL1B
148.9TNF, IL1R1, IL1B
15
Hide members
8.9TNF, IL1R1, IL1B
16
Hide members
8.9IL1B, IL1R1, TNF
17
Hide members
8.9IL1B, IL1R1, TNF
18
Hide members
8.9IL1B, IL1R1, TNF
198.9IL1B, IL1R1, TNF
208.9IL1B, IL1R1, TNF
218.9IL1B, IL1R1, TNF
228.9IL1B, TNF, NLRP3
23
Hide members
8.9IL1B, TNF, NLRP3
248.8TNF, IL1RN, IL1B
258.7ESR1, IL1R1, TNF
26
Hide members
8.5NLRP3, TNF, IL1R1, IL1B
27
Immune response Bacterial infections in normal airways
Hide members
8.4IL1B, IL1R1, IL1RN, TNF
28
Hide members
8.1NLRP3, MBL2, IL1RN, IL1R1, IL1B

Compounds for genes affiliated with Vulvar Vestibulitis Syndrome

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1tenidap45 2911.5IL1R1
2cuprophan4510.4IL1R1
3prednisolone45 29 1112.1IL1R1, MBL2
4pentoxifylline45 1111.0IL1R1, IL1RN
5monosodium urate459.5IL1B, IL1R1
6zymosan459.4IL1RN, TNF, MBL2
7adalimumab45 50 1111.4IL1R1, IL1RN, TNF
8n,n-dimethylsphingosine45 6010.3IL1B, TNF
9vesnarinone459.3IL1B, TNF
10vitamin d459.3MC1R, IL1R1, ESR1
11il-12459.3TNF, IL1R1, IL1B
12polysulfone459.3IL1RN, IL1R1, IL1B
13diphenyleneiodonium459.3TNF, IL1R1, IL1B
14chloroquine45 2 50 29 1113.2TNF, IL1RN, IL1R1
15ccl345 2910.2IL1B, IL1R1, TNF
16toxin-1459.2IL1B, IL1RN, TNF
17ibuprofen45 29 50 11 2413.2IL1B, IL1R1, IL1RN
18thalidomide45 50 60 1112.2IL1B, IL1R1, TNF
19ns 39845 6010.2IL1B, IL1RN, TNF
20l-nmma459.1IL1B, IL1RN, TNF
21corticosterone45 60 2411.1IL1B, IL1R1, IL1RN
22cicaprost45 2910.0IL1B, TNF
23fibrinogen458.9MBL2, TNF, IL1RN, IL1R1
24acth458.9MC1R, IL1RN, IL1R1, IL1B
25rosiglitazone45 50 29 11 2412.9TNF, IL1RN, IL1R1
26polymyxin b458.9IL1B, IL1RN, TNF, MBL2
27gold sodium thiomalate458.8TNF, IL1RN, IL1R1, IL1B
28sulfasalazine45 29 50 1111.8TNF, IL1RN, IL1R1, IL1B
29etanercept45 50 1110.8TNF, IL1RN, IL1R1, IL1B
30il 10458.8IL1B, IL1R1, IL1RN, TNF
31infliximab45 50 1110.8TNF, IL1RN, IL1R1, IL1B
32ivig458.8TNF, IL1RN, IL1R1, IL1B
33leukotriene b445 60 2410.8TNF, IL1RN, IL1R1, IL1B
34mifepristone45 60 29 1111.8IL1R1, IL1B, ESR1
35prostaglandin458.8TNF, IL1RN, IL1R1, IL1B
36indomethacin45 60 29 1111.7TNF, IL1RN, IL1R1, IL1B
37sb 20358045 609.7TNF, IL1RN, IL1R1, IL1B
38superoxide45 249.5MBL2, TNF, IL1RN, IL1B
39lipoteichoic acid458.5MBL2, TNF, IL1RN, IL1R1, IL1B
40peptidoglycan45 299.5MBL2, TNF, IL1RN, IL1R1, IL1B
41neopterin458.5MBL2, TNF, IL1RN, IL1R1, IL1B
42rantes458.4MBL2, TNF, IL1RN, IL1R1, IL1B
43anakinra45 119.4IL1B, IL1R1, IL1RN, TNF, NLRP3
44dexamethasone45 50 29 1111.4MBL2, TNF, IL1RN, IL1R1, IL1B
45actinomycin d458.4TNF, IL1R1, IL1B, ESR1
46nitric oxide45 11 2410.3MBL2, TNF, IL1RN, IL1R1, IL1B
47leflunomide50 45 1110.0TNF, IL1RN, IL1R1, IL1B, ESR1
48retinoic acid45 248.8TNF, IL1RN, IL1R1, IL1B, ESR1
49vegf457.6MBL2, TNF, IL1RN, IL1R1, IL1B, ESR1
50methotrexate45 50 119.6NLRP3, TNF, IL1RN, IL1R1, IL1B, ESR1

GO Terms for genes affiliated with Vulvar Vestibulitis Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4IL1B, IL1RN, TNF, MBL2

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:0441309.9TNF, MBL2
2chronic inflammatory response to antigenic stimulusGO:0024399.8IL1RN, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IL1B
4sequestering of triglycerideGO:0307309.7TNF, IL1B
5positive regulation of heterotypic cell-cell adhesionGO:0341169.7IL1B, TNF
6positive regulation of fever generationGO:0316229.7IL1B, TNF
7positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, TNF
8positive regulation of JUN kinase activityGO:0435079.7TNF, IL1RN
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7TNF, IL1B
10positive regulation of membrane protein ectodomain proteolysisGO:0510449.6IL1B, TNF
11negative regulation of lipid catabolic processGO:0509959.6IL1B, TNF
12positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
13negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
14defense response to Gram-positive bacteriumGO:0508309.6TNF, MBL2
15positive regulation of mitosisGO:0458409.6TNF, IL1B
16positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.6TNF, NLRP3
17lipopolysaccharide-mediated signaling pathwayGO:0316639.5TNF, IL1B
18cellular response to organic cyclic compoundGO:0714079.5IL1B, TNF
19acute-phase responseGO:0069539.5MBL2, IL1RN
20protein kinase B signaling cascadeGO:0434919.5TNF, IL1B
21positive regulation of interferon-gamma productionGO:0327299.4IL1B, TNF
22positive regulation of NF-kappaB transcription factor activityGO:0510929.2IL1B, TNF, NLRP3
23positive regulation of interleukin-6 productionGO:0327559.0IL1B, TNF
24positive regulation of nitric oxide biosynthetic processGO:0454298.9ESR1, IL1B, TNF
25inflammatory responseGO:0069548.9IL1B, TNF, NLRP3
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9TNF, IL1B, ESR1
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, MC1R, IL1B, ESR1

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.3IL1B, IL1RN

Products for genes affiliated with Vulvar Vestibulitis Syndrome

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Sources for Vulvar Vestibulitis Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet