MCID: VLV042
MIFTS: 40

Vulvar Vestibulitis Syndrome malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Aliases & Classifications for Vulvar Vestibulitis Syndrome

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Vulvar Vestibulitis Syndrome, Aliases & Descriptions:

Name: Vulvar Vestibulitis Syndrome 41
Vulvar Dysesthesia Localized in the Vestibule 41
Familial Neurocardiogenic Syncope 60
 
Vulvar Vestibulitis 60
Vvs 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Summaries for Vulvar Vestibulitis Syndrome

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Wikipedia:63 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

MalaCards based summary: Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to pyoderma gangrenosum and malaria. An important gene associated with Vulvar Vestibulitis Syndrome is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are TRAF Pathway and Th17 Differentiation. The compounds zymosan and adalimumab have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Related Diseases for Vulvar Vestibulitis Syndrome

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Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1pyoderma gangrenosum10.5NLRP3
2malaria10.4TNF
3dengue shock syndrome10.4IL1RN
4gastric cancer risk after h. pylori infection10.4IL1RN
5hyper-igd syndrome10.4IL1RN
6vaccinia10.4
7intervertebral disc disease10.4IL1B
8periodontal disease10.4TNF
9periodontitis10.4IL1B
10skin disease10.3IL1B
11urethritis10.3
12vulvovaginitis10.3
13vulvovaginal candidiasis10.3
14candidiasis10.3
15psychosexual disorder10.3
16vaginitis10.3
17aseptic meningitis10.3NLRP3, IL1R1
18schnitzler syndrome10.2IL1R1, IL1RN
19familial mediterranean fever, ar10.2NLRP3, TNF
20exanthem10.2IL1RN, NLRP3
21behcet's disease10.2TNF, MBL2
22alopecia areata10.2IL1R1, IL1RN
23acute respiratory distress syndrome10.2IL1R1, TNF
24syncope, familial vasovagal10.2
25hiv-110.2
26molluscum contagiosum10.2
27otitis media10.2IL1B, MBL2
28interstitial lung disease10.2IL1R1, IL1RN
29iga glomerulonephritis10.2IL1R1, MBL2
30gout10.2NLRP3, IL1B
31shigellosis10.2IL1R1, IL1B
32meningitis10.2MBL2, IL1B
33graft-versus-host disease, protection against10.1IL1R1, TNF
34aids dementia complex10.1TNF, IL1B
35arthritis10.1TNF, IL1B
36psoriatic arthritis10.1TNF, IL1B
37uveitis10.1TNF, IL1R1
38respiratory failure10.1IL1B, TNF
39neisseria meningitidis infection10.1IL1R1, IL1RN, MBL2
40acute pancreatitis10.1IL1RN, IL1R1
41vasculitis10.1MBL2, TNF
42peritonitis10.1TNF, IL1B
43nephritis10.1IL1RN, IL1R1
44bacterial vaginosis10.0IL1R1, IL1B, MBL2
45familial cold autoinflammatory syndrome10.0IL1R1, IL1B, NLRP3
46osteoporosis10.0IL1RN, ESR1
47muckle-wells syndrome10.0IL1R1, IL1B, NLRP3
48acute graft versus host disease10.0IL1RN, IL1R1, TNF
49juvenile rheumatoid arthritis10.0TNF, IL1R1, IL1RN
50spondyloarthropathy 110.0TNF, IL1R1, IL1RN

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to vulvar vestibulitis syndrome

Symptoms for Vulvar Vestibulitis Syndrome

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Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

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Drug clinical trials:

Search ClinicalTrials for Vulvar Vestibulitis Syndrome

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

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Anatomical Context for Vulvar Vestibulitis Syndrome

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MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

31
Testes

Animal Models for Vulvar Vestibulitis Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5TNF, MC1R, ESR1, NLRP3
2MP:00053708.2NLRP3, IL1R1, ESR1, TNF
3MP:00053678.1ESR1, IL1R1, NLRP3, MBL2
4MP:00020067.9TNF, MC1R, ESR1, IL1R1, IL1B
5MP:00036317.6NLRP3, IL1B, IL1R1, ESR1, TNF
6MP:00107717.6TNF, MC1R, ESR1, IL1R1, IL1RN, NLRP3
7MP:00053857.6TNF, ESR1, IL1R1, IL1RN, IL1B
8MP:00053847.5TNF, MC1R, ESR1, IL1R1, IL1RN, NLRP3
9MP:00053787.5TNF, MC1R, ESR1, IL1R1, IL1RN, NLRP3
10MP:00053907.4TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3
11MP:00107687.1TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3
12MP:00053977.1MBL2, TNF, ESR1, IL1R1, IL1RN, IL1B
13MP:00053877.0TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3
14MP:00053767.0TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3

Publications for Vulvar Vestibulitis Syndrome

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Articles related to Vulvar Vestibulitis Syndrome:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Elevated tissue levels of tumor necrosis factor-I+ in vulvar vestibulitis syndrome. (25551965)
2014
2
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. (19254587)
2009
3
Overlap between orofacial pain and vulvar vestibulitis syndrome. (18287822)
2008
4
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. (17136588)
2007
5
A cognitive-behavioral group program for women with vulvar vestibulitis syndrome (VVS): factors associated with treatment success. (16809249)
2006
6
Surgical treatment for the vulvar vestibulitis syndrome. (16449109)
2006
7
Hyperoxaluria in women with vulvar vestibulitis syndrome. (16846091)
2006
8
Psychological factors associated with perception of experimental pain in vulvar vestibulitis syndrome. (16020147)
2005
9
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. (15772910)
2005
10
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. (15836975)
2005
11
Vulvar vestibulitis syndrome: a review. (15927350)
2005
12
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. (16050536)
2005
13
The major histopathologic characteristics in the vulvar vestibulitis syndrome. (15542936)
2005
14
Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms. (15041996)
2004
15
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. (15305821)
2004
16
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. (15162345)
2004
17
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. (15295354)
2004
18
Vulvar vestibulitis syndrome: a clinical approach. (15205070)
2004
19
To cut or not to cut: treatment of vulvar vestibulitis syndrome. (15376407)
2004
20
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. (15467537)
2004
21
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. (12593899)
2003
22
Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. (14584306)
2003
23
Differential characterization of women with vulvar vestibulitis syndrome. (12237632)
2002
24
In favor of an integrated pain-relief treatment approach for vulvar vestibulitis syndrome. (12061041)
2002
25
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome. (11967493)
2002
26
Web-enabled Glazer surface electromyographic protocol for the remote, real-time assessment and rehabilitation of pelvic floor dysfunction in vulvar vestibulitis syndrome. A case report. (12380455)
2002
27
Vulvar vestibulitis syndrome: care made to measure. (12061037)
2002
28
Combined vulvar vestibulitis syndrome with vaginismus: which to treat first? (11554214)
2001
29
A review of physical and psychological factors in vulvar vestibulitis syndrome. (11589808)
2001
30
Psychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndrome. (11690731)
2001
31
Vulvar vestibulitis syndrome: reliability of diagnosis and evaluation of current diagnostic criteria. (11430955)
2001
32
Vulvar vestibulitis syndrome (VVS) is not primarily a psychosexual disorder. (10870796)
2000
33
Vulvar vestibulitis syndrome and vaginismus. A case report. (10756500)
2000
34
Vulvar Vestibulitis Syndrome: A Post-infectious Entity? (11095904)
2000
35
Vulvar vestibulitis syndrome. (10554969)
1999
36
Human papillomavirus with co-existing vulvar vestibulitis syndrome and vestibular papillomatosis. (10366048)
1999
37
Vulvar vestibulitis syndrome: an often unrecognized cause of dyspareunia. (10099756)
1999
38
Epidemiology of vulvar vestibulitis syndrome: an exploratory case-control study. (10616356)
1999
39
Increased intraepithelial innervation in women with vulvar vestibulitis syndrome. (9813445)
1998
40
Polymerase chain reaction search for viral etiology of vulvar vestibulitis syndrome. (8694039)
1996
41
Behavioral approach with or without surgical intervention to the vulvar vestibulitis syndrome: a prospective randomized and non-randomized study. (8892160)
1996
42
Treatment of vulvar vestibulitis syndrome with electromyographic biofeedback of pelvic floor musculature. (7623358)
1995
43
Vulvar vestibulitis syndrome: an exploratory case-control study. (8272306)
1994
44
Vaginismus: an important factor in the evaluation and management of vulvar vestibulitis syndrome. (8001875)
1994
45
Intralesional alpha interferon. Cost-effective therapy for vulvar vestibulitis syndrome. (8382744)
1993
46
Antitrichomonal (cross) immunity as an important factor in vulvar vestibulitis syndrome pathogenesis. (1607200)
1992
47
Vulvar vestibulitis syndrome. (1606769)
1992
48
Vulvar vestibulitis syndrome: an overview. (1659198)
1991
49
Vulvar vestibulitis syndrome: a clinico-pathological study. (1883796)
1991
50
Vulvar vestibulitis syndrome. (3560069)
1987

Variations for Vulvar Vestibulitis Syndrome

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Expression for genes affiliated with Vulvar Vestibulitis Syndrome

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Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for genes affiliated with Vulvar Vestibulitis Syndrome

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Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TNF
2
Show member pathways
9.4IL1B, IL1R1
3
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.4IL1B, IL1R1
49.3TNF, IL1B
59.3TNF, IL1B
69.3TNF, IL1B
79.3TNF, IL1B
89.3TNF, IL1B
99.3TNF, IL1B
109.3TNF, IL1B
11
Show member pathways
IL27-mediated signaling events36
9.3TNF, IL1B
129.3IL1B, TNF
139.3IL1B, TNF
149.3IL1B, TNF
158.9TNF, IL1B, NLRP3
16
Show member pathways
8.9TNF, IL1B, NLRP3
17
Show member pathways
8.9NLRP3, IL1B, TNF
18
Show member pathways
8.9IL1B, IL1RN, IL1R1
19
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
8.9IL1B, IL1RN, IL1R1
20
Show member pathways
8.9IL1B, IL1RN, IL1R1
21
Show member pathways
Serotonin Transporter Activity36
8.9TNF, IL1R1, IL1B
228.9TNF, IL1R1, IL1B
23
Show member pathways
8.9TNF, IL1R1, IL1B
24
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.9TNF, IL1R1, IL1B
25
Show member pathways
Immune response MIF in innate immunity response58
8.9TNF, IL1R1, IL1B
268.9TNF, IL1R1, IL1B
27
Show member pathways
8.9TNF, IL1R1, IL1B
28
Show member pathways
8.9TNF, IL1R1, IL1B
29
Show member pathways
8.9IL1B, IL1R1, TNF
308.9IL1B, IL1R1, TNF
31
Show member pathways
MAPK signaling pathway36
8.9IL1B, IL1R1, TNF
328.9IL1B, IL1R1, TNF
338.9IL1B, IL1R1, TNF
348.8IL1B, IL1RN, TNF
358.7IL1R1, ESR1, TNF
36
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.6IL1B, IL1R1, ESR1
37
Show member pathways
8.1TNF, ESR1, IL1R1, IL1B
38
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
7.9NLRP3, IL1B, IL1RN, IL1R1, TNF

Compounds for genes affiliated with Vulvar Vestibulitis Syndrome

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Compounds related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1zymosan439.5TNF, IL1RN, MBL2
2adalimumab43 49 1211.4IL1RN, IL1R1, TNF
3tenidap43 2810.3TNF, IL1R1, IL1B
4il-12439.3TNF, IL1R1, IL1B
5cuprophan439.2IL1B, IL1RN, IL1R1
6polysulfone439.2IL1R1, IL1RN, IL1B
7toxin-1439.2TNF, IL1RN, IL1B
8p003439.2MBL2, IL1RN, IL1R1
9diphenyleneiodonium439.1TNF, IL1R1, IL1B
10ns 39843 5910.1IL1B, IL1RN, TNF
11chloroquine43 2 49 28 1213.1TNF, IL1R1, IL1RN
12ccl343 2810.1TNF, IL1R1, IL1B
13ibuprofen43 28 49 24 1213.1IL1B, IL1RN, IL1R1
14l-nmma439.1IL1B, IL1RN, TNF
15prednisolone43 28 1211.0MBL2, IL1RN, IL1R1, TNF
16thalidomide43 49 59 1212.0TNF, IL1R1, IL1B
17polymyxin b438.9TNF, IL1RN, IL1B, MBL2
18fibrinogen438.9MBL2, IL1RN, IL1R1, TNF
19corticosterone43 59 2410.9IL1R1, IL1RN, IL1B
20acth438.8MC1R, IL1R1, IL1RN, IL1B
21gold sodium thiomalate438.8IL1B, IL1RN, IL1R1, TNF
22sulfasalazine28 43 49 1211.8IL1B, IL1RN, IL1R1, TNF
23etanercept43 49 1210.8TNF, IL1R1, IL1RN, IL1B
24il 10438.8TNF, IL1R1, IL1RN, IL1B
25infliximab43 49 1210.8IL1B, IL1RN, IL1R1, TNF
26ivig438.8TNF, IL1R1, IL1RN, IL1B
27pentoxifylline43 129.8IL1B, IL1RN, IL1R1, TNF
28leukotriene b443 59 2410.8IL1B, IL1RN, IL1R1, TNF
29hydrocortisone43 2 59 1211.7TNF, IL1R1, IL1RN, IL1B
30endotoxin438.7IL1B, IL1RN, IL1R1, TNF
31prostaglandin438.7TNF, IL1R1, IL1RN, IL1B
32indomethacin43 28 59 1211.7IL1B, IL1RN, IL1R1, TNF
33sb 20358043 599.7TNF, IL1R1, IL1RN, IL1B
34mifepristone43 28 59 1211.5IL1B, IL1R1, ESR1
35lipoteichoic acid438.5TNF, IL1R1, IL1RN, IL1B, MBL2
36peptidoglycan43 289.5TNF, IL1R1, IL1RN, IL1B, MBL2
37neopterin438.4TNF, IL1R1, IL1RN, IL1B, MBL2
38rantes438.4TNF, IL1R1, IL1RN, IL1B, MBL2
39pge2438.4IL1B, IL1RN, IL1R1, TNF
40anakinra43 129.4NLRP3, IL1B, IL1RN, IL1R1, TNF
41vitamin d438.4MC1R, ESR1, IL1R1, IL1RN, MBL2
42dexamethasone43 49 28 1211.3TNF, IL1R1, IL1RN, IL1B, MBL2
43nitric oxide43 24 1210.3TNF, IL1R1, IL1RN, IL1B, MBL2
44actinomycin d438.3TNF, ESR1, IL1R1, IL1B
45superoxide43 249.2TNF, IL1RN, IL1B, MBL2
46leflunomide43 49 1210.0TNF, ESR1, IL1R1, IL1RN, IL1B
47cycloheximide437.9TNF, ESR1, IL1R1, IL1RN, IL1B
48retinoic acid43 248.7TNF, ESR1, IL1R1, IL1RN, IL1B
49vegf437.6TNF, ESR1, IL1R1, IL1RN, IL1B, MBL2
50methotrexate49 43 129.6TNF, ESR1, IL1R1, IL1RN, IL1B, NLRP3

GO Terms for genes affiliated with Vulvar Vestibulitis Syndrome

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Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.9TNF, IL1R1, MBL2
2extracellular regionGO:00055768.5MBL2, IL1B, IL1R1, TNF
3extracellular spaceGO:00056158.4MBL2, IL1B, IL1RN, TNF

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:004413010.0TNF, MBL2
2defense response to Gram-positive bacteriumGO:00508309.9TNF, MBL2
3chronic inflammatory response to antigenic stimulusGO:00024399.8IL1RN, TNF
4interleukin-1 beta productionGO:00326119.8IL1B, NLRP3
5acute-phase responseGO:00069539.8IL1RN, MBL2
6positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00432809.8TNF, NLRP3
7positive regulation of JUN kinase activityGO:00435079.8TNF, IL1RN
8positive regulation of calcidiol 1-monooxygenase activityGO:00605599.7TNF, IL1B
9sequestering of triglycerideGO:00307309.7TNF, IL1B
10fever generationGO:00016609.7IL1RN, IL1B
11positive regulation of heterotypic cell-cell adhesionGO:00341169.7TNF, IL1B
12positive regulation of fever generationGO:00316229.7TNF, IL1B
13positive regulation of chemokine biosynthetic processGO:00450809.7TNF, IL1B
14regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.7TNF, IL1B
15positive regulation of membrane protein ectodomain proteolysisGO:00510449.7IL1B, TNF
16negative regulation of lipid catabolic processGO:00509959.7IL1B, TNF
17positive regulation of NF-kappaB import into nucleusGO:00423469.7IL1B, TNF
18lipopolysaccharide-mediated signaling pathwayGO:00316639.7TNF, IL1B
19positive regulation of mitosisGO:00458409.7IL1B, TNF
20positive regulation of protein kinase B signalingGO:00518979.6MC1R, TNF
21protein kinase B signalingGO:00434919.6TNF, IL1B
22negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.6IL1B, TNF
23cellular response to organic cyclic compoundGO:00714079.6TNF, IL1B
24positive regulation of interferon-gamma productionGO:00327299.6TNF, IL1B
25positive regulation of interleukin-6 productionGO:00327559.5IL1B, TNF
26positive regulation of JNK cascadeGO:00463309.5IL1B, TNF
27MAPK cascadeGO:00001659.4TNF, IL1B
28response to glucocorticoidGO:00513849.4TNF, IL1RN
29regulation of insulin secretionGO:00507969.3IL1B, TNF
30positive regulation of NF-kappaB transcription factor activityGO:00510929.3NLRP3, IL1B, TNF
31activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.2NLRP3, TNF
32inflammatory responseGO:00069549.2NLRP3, IL1B, TNF
33immune responseGO:00069559.1IL1R1, IL1RN, IL1B
34negative regulation of gene expressionGO:00106299.0TNF, ESR1
35positive regulation of nitric oxide biosynthetic processGO:00454298.9IL1B, ESR1, TNF
36positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL1B, ESR1, TNF
37positive regulation of transcription from RNA polymerase II promoterGO:00459448.5IL1B, ESR1, MC1R, TNF

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.5IL1R1, TNF
2interleukin-1 receptor bindingGO:00051499.0IL1B, IL1RN

Products for genes affiliated with Vulvar Vestibulitis Syndrome

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Sources for Vulvar Vestibulitis Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
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