VVS
MCID: VLV042
MIFTS: 40

Vulvar Vestibulitis Syndrome (VVS) malady

Categories: Rare diseases

Aliases & Classifications for Vulvar Vestibulitis Syndrome

Aliases & Descriptions for Vulvar Vestibulitis Syndrome:

Name: Vulvar Vestibulitis Syndrome 50
Vulvar Dysesthesia Localized in the Vestibule 50
Vulvar Vestibulitis 69
Vvs 50

Classifications:



Summaries for Vulvar Vestibulitis Syndrome

MalaCards based summary : Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to syncope, familial vasovagal and vaccinia. An important gene associated with Vulvar Vestibulitis Syndrome is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Prolactin Signaling Pathway. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

Related Diseases for Vulvar Vestibulitis Syndrome

Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 syncope, familial vasovagal 11.6
2 vaccinia 11.2
3 pseudoainhum 10.3 IL1B MBL2
4 giant cell glioblastoma 10.2 IL1B IL1R1
5 hepatocellular carcinoma 10.2 IL1B IL1RN
6 intussusception 10.2 IL1B TNF
7 tau syndrome 10.2 IL1B TNF
8 stocco dos santos syndrome 10.2 IL1B TNF
9 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 IL1B TNF
10 twin-to-twin transfusion syndrome 10.2 IL1B TNF
11 anal paget's disease 10.2 IL1B TNF
12 cataract 10.2 IL1B TNF
13 tracheal calcification 10.2 MBL2 TNF
14 hepatic encephalopathy 10.2 IL1B TNF
15 bipolar i disorder 10.2 IL1B TNF
16 human immunodeficiency virus infectious disease 10.2 IL1B TNF
17 cerebellar disease 10.2 IL1B TNF
18 tinea capitis 10.2 IL1B TNF
19 amyotrophic lateral sclerosis type 14 10.2 IL1B TNF
20 measles 10.2 IL1B TNF
21 parkinson disease 11 10.2 IL1B TNF
22 carbuncle 10.2 ESR1 IL1B
23 osteochondrodysplasia 10.2 ESR1 IL1B
24 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL1B TNF
25 gastroduodenal crohn's disease 10.2 IL1B TNF
26 nemaline myopathy 1, autosomal dominant or recessive 10.2 IL1RN TNF
27 larynx leiomyoma 10.1 ESR1 IL1B
28 childhood endodermal sinus tumor 10.1 IL1B TNF
29 steroid dehydrogenase deficiency dental anomalies 10.1 IL1B TNF
30 mikulicz disease 10.1 IL1B TNF
31 acquired thrombocytopenia 10.1 IL1B TNF
32 phlyctenulosis 10.1 MBL2 TNF
33 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL1B TNF
34 ectodermal dysplasia bartalos type 10.1 IL1B TNF
35 mental retardation hypotonia skin hyperpigmentation 10.1 IL1B IL1RN MBL2
36 oral cavity carcinoma in situ 10.1 IL1B IL1RN MBL2
37 glossitis 10.1 IL1B IL1RN
38 bile duct signet ring cell carcinoma 10.1 IL1R1 TNF
39 mineral metabolism disease 10.1 IL1B TNF
40 amelanotic melanoma 10.1 IL1B NLRP3
41 retinal cancer 10.1 IL1B NLRP3
42 nephropathy familial with hyperuricemia 10.1 IL1R1 IL1RN MBL2
43 primary ciliary dyskinesia 10.1 IL1R1 TNF
44 childhood type dermatomyositis 10.1 IL1B MBL2 TNF
45 nephropathy with pretibial epidermolysis bullosa and deafness 10.1 IL1B MBL2 TNF
46 pulmonary eosinophilia 10.1 IL1B MBL2 TNF
47 rectum squamous cell carcinoma 10.1 IL1B MBL2 TNF
48 respiratory system disease 10.0 IL1B IL1R1 TNF
49 functional gastric disease 10.0 IL1R1 MBL2 TNF
50 coloboma of optic papilla 10.0 IL1R1 NLRP3

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to Vulvar Vestibulitis Syndrome

Symptoms & Phenotypes for Vulvar Vestibulitis Syndrome

MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IL1RN MBL2 MC1R ESR1 NLRP3 IL1B
2 homeostasis/metabolism MP:0005376 9.87 IL1R1 IL1RN MBL2 ESR1 NLRP3 IL1B
3 immune system MP:0005387 9.86 IL1R1 IL1RN MBL2 MC1R ESR1 NLRP3
4 integument MP:0010771 9.7 IL1RN MC1R ESR1 NLRP3 IL1B TNF
5 neoplasm MP:0002006 9.35 IL1R1 MC1R ESR1 IL1B TNF
6 skeleton MP:0005390 9.1 IL1R1 IL1RN ESR1 NLRP3 IL1B TNF

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Drugs for Vulvar Vestibulitis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 1 137-58-6 3676
3 Cholinergic Agents Phase 4,Phase 3,Phase 2
4 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
5 abobotulinumtoxinA Phase 4,Phase 3
6 incobotulinumtoxinA Phase 4,Phase 3
7 onabotulinumtoxinA Phase 4,Phase 3
8 Botulinum Toxins Phase 4,Phase 3,Phase 2
9 Botulinum Toxins, Type A Phase 4,Phase 3
10 Sodium Channel Blockers Phase 4,Phase 2,Phase 1
11 Anesthetics Phase 4,Phase 2,Phase 1
12 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Anesthetics, Local Phase 4,Phase 2,Phase 1
15 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1
16 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
17
Nifedipine Approved Phase 3 21829-25-4 4485
18
Capsaicin Approved Phase 2, Phase 3,Phase 1 404-86-4 1548943
19
Milnacipran Approved Phase 3 92623-85-3 65833
20
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
21 calcium channel blockers Phase 3,Phase 2
22
Serotonin Phase 3 50-67-9 5202
23 Serotonin Agents Phase 3
24 Adrenergic Agents Phase 3
25 Serotonin Uptake Inhibitors Phase 3
26 Neurotransmitter Uptake Inhibitors Phase 3
27 Tocolytic Agents Phase 3
28 Dermatologic Agents Phase 2, Phase 3,Phase 1
29 Vasodilator Agents Phase 3
30 Antidepressive Agents Phase 3
31 Psychotropic Drugs Phase 3,Phase 2
32 Calcium, Dietary Phase 3,Phase 2
33 Antipruritics Phase 2, Phase 3,Phase 1
34 Neuromuscular Agents Phase 3
35 Pharmaceutical Solutions Phase 3
36 Tomato Nutraceutical Phase 3
37
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
38
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
39
Diphenhydramine Approved Phase 2 58-73-1, 147-24-0 3100
40
Promethazine Approved Phase 2 60-87-7 4927
41
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
42
Petrolatum Approved Phase 2 8009-03-8
43
Histamine Phosphate Phase 2 51-74-1 65513
44 Analgesics Phase 2
45 Gastrointestinal Agents Phase 2
46 Histamine Antagonists Phase 2
47 Histamine H1 Antagonists Phase 2
48 Tranquilizing Agents Phase 2
49 Anti-Allergic Agents Phase 2
50 Anti-Anxiety Agents Phase 2

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4
2 Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia Recruiting NCT01935063 Phase 4
3 Dysbiosis in Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
4 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3
5 Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis Completed NCT00496184 Phase 3
6 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Recruiting NCT02858219 Phase 3
7 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Recruiting NCT02854670 Phase 2, Phase 3
8 Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Not yet recruiting NCT02773641 Phase 3
9 Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia Unknown status NCT01747161 Phase 2
10 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2
11 Enoxaparin as Treatment for Vulvodynia Completed NCT00874484 Phase 2
12 Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort Completed NCT00590590 Phase 2
13 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis Terminated NCT00450242 Phase 2
14 Pregabalin for the Treatment of Vulvodynia Terminated NCT00853229 Phase 2
15 Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study Active, not recruiting NCT01996384 Phase 1
16 Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine Completed NCT00276068
17 Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia Completed NCT02494934
18 The Use of Acupuncture for the Treatment of Vulvar Vestibulitis Completed NCT02362763
19 "Vestibulitis Educational Seminar Trial" Study Completed NCT00278850
20 Integrated Mindfulness for Provoked Vestibulodynia Completed NCT01704443
21 Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia Completed NCT01455350
22 Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Completed NCT02204319
23 Pilot Study to Assess the Efficacy of Cognitive-behavioral Couple Therapy for Provoked Vestibulodynia Completed NCT01582373
24 Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia Completed NCT02858375
25 Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Completed NCT02543593
26 A Search for Helicobacter Pylori in Localized Vulvodynia Completed NCT00501774
27 Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Completed NCT01731288
28 To Evaluate if the Medication Gabapentin Lessens Vulvar Pain Completed NCT00390013
29 Acupuncture for the Treatment of Vulvodynia Completed NCT02197429
30 Acupuncture for Vulvodynia: A Pre-pilot Study Completed NCT02704234
31 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
32 Outcomes of Delivery in Patients With Dyspareunia Completed NCT01753258
33 The Effectiveness of Vestibulectomy Completed NCT00873301
34 A Randomized Clinical Trial for Women With Vulvodynia Completed NCT00607490
35 Physiotherapy Intervention for Provoked Vulvar Vestibulodynia Recruiting NCT01628679
36 Subtypes of Provoked Vestibulodynia Recruiting NCT02712814
37 The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia Recruiting NCT02892214
38 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
39 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Active, not recruiting NCT01704456
40 Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia Terminated NCT01149031
41 Study of Emu Oil vs. Placebo for Vulvar Pain in Women. Terminated NCT01295268
42 Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia Withdrawn NCT01741948

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

39
Testes

Publications for Vulvar Vestibulitis Syndrome

Articles related to Vulvar Vestibulitis Syndrome:

(show top 50) (show all 82)
id Title Authors Year
1
The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome. ( 24961922 )
2014
2
Elevated tissue levels of tumor necrosis factor-I+ in vulvar vestibulitis syndrome. ( 25551965 )
2014
3
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. ( 20168100 )
2009
4
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. ( 19622972 )
2009
5
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. ( 19254587 )
2009
6
Somatization and psychological distress among women with vulvar vestibulitis syndrome. ( 18635182 )
2008
7
Overlap between orofacial pain and vulvar vestibulitis syndrome. ( 18287822 )
2008
8
Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism. ( 18166320 )
2008
9
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. ( 17936236 )
2008
10
Human papillomavirus in vulvar vestibulitis syndrome. ( 17694965 )
2007
11
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. ( 17136588 )
2007
12
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. ( 17970976 )
2007
13
Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. ( 17367437 )
2007
14
Vulvar vestibulitis syndrome. ( 17064641 )
2006
15
A conceptual model for the pathophysiology of vulvar vestibulitis syndrome. ( 16719941 )
2006
16
Hyperoxaluria in women with vulvar vestibulitis syndrome. ( 16846091 )
2006
17
Surgical treatment of vulvar vestibulitis syndrome: outcome assessment derived from a postoperative questionnaire. ( 16942537 )
2006
18
A cognitive-behavioral group program for women with vulvar vestibulitis syndrome (VVS): factors associated with treatment success. ( 16809249 )
2006
19
Surgical techniques: Surgery for Vulvar Vestibulitis syndrome. ( 16681483 )
2006
20
Surgical treatment for the vulvar vestibulitis syndrome. ( 16449109 )
2006
21
Tender point examination in women with vulvar vestibulitis syndrome. ( 16926575 )
2006
22
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. ( 16050536 )
2005
23
Vulvar vestibulitis syndrome: a review. ( 15927350 )
2005
24
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. ( 15772910 )
2005
25
Psychological aspects of vulvar vestibulitis syndrome. ( 16050535 )
2005
26
The major histopathologic characteristics in the vulvar vestibulitis syndrome. ( 15542936 )
2005
27
Psychological factors associated with perception of experimental pain in vulvar vestibulitis syndrome. ( 16020147 )
2005
28
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. ( 15836975 )
2005
29
Vulvar vestibulitis syndrome: an important factor in the evaluation of lifelong vaginismus? ( 16457419 )
2005
30
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. ( 15467537 )
2004
31
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. ( 15162345 )
2004
32
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. ( 15305821 )
2004
33
To cut or not to cut: treatment of vulvar vestibulitis syndrome. ( 15376407 )
2004
34
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. ( 15295354 )
2004
35
Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative? ( 15775875 )
2004
36
A new instrument for pain assessment in vulvar vestibulitis syndrome. ( 15043051 )
2004
37
Vulvar vestibulitis syndrome: a clinical approach. ( 15205070 )
2004
38
Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms. ( 15041996 )
2004
39
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. ( 12593899 )
2003
40
Estrogen receptor expression in vulvar vestibulitis syndrome. ( 14520218 )
2003
41
Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. ( 14584306 )
2003
42
Hypnotherapy as a treatment for vulvar vestibulitis syndrome: a case report. ( 12851128 )
2003
43
Web-enabled Glazer surface electromyographic protocol for the remote, real-time assessment and rehabilitation of pelvic floor dysfunction in vulvar vestibulitis syndrome. A case report. ( 12380455 )
2002
44
Vulvar vestibulitis syndrome: care made to measure. ( 12061037 )
2002
45
Differential characterization of women with vulvar vestibulitis syndrome. ( 12237632 )
2002
46
Vulvar vestibulitis syndrome: an overview of non-surgical treatment. ( 11858882 )
2002
47
Physical therapy for vulvar vestibulitis syndrome: a retrospective study. ( 11995597 )
2002
48
In favor of an integrated pain-relief treatment approach for vulvar vestibulitis syndrome. ( 12061041 )
2002
49
Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome. ( 11932072 )
2002
50
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome. ( 11967493 )
2002

Variations for Vulvar Vestibulitis Syndrome

Expression for Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for Vulvar Vestibulitis Syndrome

Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 IL1B IL1R1 IL1RN NLRP3 TNF
2
Show member pathways
12.25 ESR1 IL1B IL1RN
3
Show member pathways
12.06 IL1B IL1R1 IL1RN
4
Show member pathways
12.03 IL1B IL1R1 TNF
5
Show member pathways
11.94 IL1B IL1R1 TNF
6 11.92 IL1B IL1RN TNF
7 11.83 IL1B IL1R1 TNF
8 11.78 IL1B IL1R1 TNF
9 11.73 IL1B IL1R1 TNF
10 11.62 IL1B IL1R1 TNF
11 11.59 IL1B IL1R1 TNF
12 11.56 IL1B IL1R1 TNF
13 11.45 IL1B IL1R1 TNF
14 11.38 IL1B NLRP3 TNF
15 11.34 IL1B TNF
16 11.32 ESR1 TNF
17 11.32 IL1B TNF
18 11.31 IL1B TNF
19 11.28 IL1B TNF
20 11.23 IL1B NLRP3
21 11.16 IL1B TNF
22 11.15 IL1B TNF
23 11.1 IL1B TNF
24 11.08 IL1B TNF
25 11.06 IL1B TNF
26
Show member pathways
10.97 IL1B IL1R1 TNF
27 10.91 IL1B TNF
28 10.73 IL1B TNF
29 10.61 IL1B IL1R1 IL1RN TNF
30 10.53 IL1B IL1R1 NLRP3

GO Terms for Vulvar Vestibulitis Syndrome

Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 IL1B IL1R1 IL1RN MBL2 NLRP3 TNF

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.91 ESR1 IL1B MC1R NLRP3 TNF
2 immune response GO:0006955 9.87 IL1B IL1R1 IL1RN TNF
3 inflammatory response GO:0006954 9.73 IL1B IL1RN NLRP3 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 IL1B NLRP3 TNF
5 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B TNF
6 positive regulation of interleukin-6 production GO:0032755 9.63 IL1B TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.63 ESR1 IL1B TNF
8 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.62 NLRP3 TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL1B TNF
10 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.61 IL1B TNF
11 protein kinase B signaling GO:0043491 9.61 IL1B TNF
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.6 IL1B TNF
13 positive regulation of interleukin-8 production GO:0032757 9.59 IL1B TNF
14 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 IL1B TNF
15 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.56 MBL2 TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IL1B TNF
18 regulation of inflammatory response GO:0050727 9.54 ESR1 IL1R1 NLRP3
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.52 IL1B TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL1B TNF
21 positive regulation of chemokine biosynthetic process GO:0045080 9.48 IL1B TNF
22 regulation of establishment of endothelial barrier GO:1903140 9.4 IL1B TNF
23 positive regulation of fever generation GO:0031622 9.32 IL1B TNF
24 interleukin-1 beta production GO:0032611 9.26 IL1B NLRP3
25 sequestering of triglyceride GO:0030730 9.16 IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF
27 positive regulation of phagocytosis GO:0050766 8.8 IL1B MBL2 TNF

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1RN TNF
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Vulvar Vestibulitis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
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70 UMLS via Orphanet
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