VVS
MCID: VLV042
MIFTS: 36

Vulvar Vestibulitis Syndrome (VVS) malady

Neuronal diseases, Genetic diseases categories

Summaries for Vulvar Vestibulitis Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

MalaCards: Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to familial neurocardiogenic syncope and vaccinia. An important gene associated with Vulvar Vestibulitis Syndrome is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)), and among its related pathways are MAPK signaling pathway and Monoamine Transport. The compounds tenidap and cuprophan have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and tumorigenesis.

Aliases & Classifications for Vulvar Vestibulitis Syndrome

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60UMLS, 42NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

vulvar vestibulitis syndrome 42
vulvar dysesthesia localized in the vestibule 42
familial neurocardiogenic syncope 60
vvs 42


Related Diseases for Vulvar Vestibulitis Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to vulvar vestibulitis syndrome

Clinical Features for Vulvar Vestibulitis Syndrome

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Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vulvar Vestibulitis Syndrome

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Anatomical Context for Vulvar Vestibulitis Syndrome

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Animal Models for Vulvar Vestibulitis Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.6IL1B
2MP:00020068.6TNF, IL1B, IL1R1, MC1R
3MP:00107717.5TNF, NLRP3, IL1RN, IL1R1, ESR1, MC1R
4MP:00053787.4NLRP3, TNF, MC1R, IL1RN, IL1R1, ESR1
5MP:00053977.3NLRP3, MBL2, TNF, IL1RN, IL1R1, ESR1
6MP:00053876.9MBL2, TNF, IL1RN, IL1R1, IL1B, ESR1
7MP:00053766.7IL1R1, IL1B, ESR1, TNF, MBL2, NLRP3

Publications for Vulvar Vestibulitis Syndrome

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Genetic Variations for Vulvar Vestibulitis Syndrome

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Expression for genes affiliated with Vulvar Vestibulitis Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for genes affiliated with Vulvar Vestibulitis Syndrome

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37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 52R&D Systems
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Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1IL1R1
210.1IL1R1
3
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9.4IL1R1, IL1B
49.3TNF, IL1B
59.3TNF, IL1B
69.3TNF, IL1B
79.3IL1B, TNF
89.3IL1B, TNF
9
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8.9IL1RN, IL1R1, IL1B
10
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8.9IL1B, IL1R1, IL1RN
11
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8.9IL1B, IL1R1, IL1RN
12
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8.9TNF, IL1R1, IL1B
138.9TNF, IL1R1, IL1B
148.9TNF, IL1R1, IL1B
15
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8.9TNF, IL1R1, IL1B
16
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8.9IL1B, IL1R1, TNF
17
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8.9IL1B, IL1R1, TNF
18
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8.9IL1B, IL1R1, TNF
198.9IL1B, IL1R1, TNF
208.9IL1B, IL1R1, TNF
218.9IL1B, IL1R1, TNF
228.9IL1B, TNF, NLRP3
23
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8.9IL1B, TNF, NLRP3
248.8TNF, IL1RN, IL1B
258.7ESR1, IL1R1, TNF
26
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8.5NLRP3, TNF, IL1R1, IL1B
27
Immune response Bacterial infections in normal airways
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8.4IL1B, IL1R1, IL1RN, TNF
28
Hide members
8.1NLRP3, MBL2, IL1RN, IL1R1, IL1B

Compounds for genes affiliated with Vulvar Vestibulitis Syndrome

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1tenidap44 2811.5IL1R1
2cuprophan4410.4IL1R1
3prednisolone44 28 1112.1IL1R1, MBL2
4pentoxifylline44 1111.0IL1RN, IL1R1
5monosodium urate449.4IL1R1, IL1B
6zymosan449.4MBL2, TNF, IL1RN
7adalimumab44 49 1111.4IL1RN, TNF, IL1R1
8n,n-dimethylsphingosine44 5910.4TNF, IL1B
9vesnarinone449.3IL1B, TNF
10vitamin d449.3MC1R, IL1R1, ESR1
11il-12449.3IL1R1, IL1B, TNF
12polysulfone449.3IL1B, IL1RN, IL1R1
13diphenyleneiodonium449.3IL1B, IL1R1, TNF
14chloroquine44 2 49 28 1113.2TNF, IL1R1, IL1RN
15ccl344 2810.2IL1R1, TNF, IL1B
16toxin-1449.2IL1RN, IL1B, TNF
17ibuprofen44 28 49 11 2413.2IL1B, IL1RN, IL1R1
18thalidomide44 49 59 1112.2TNF, IL1B, IL1R1
19ns 39844 5910.2IL1B, TNF, IL1RN
20l-nmma449.1IL1B, IL1RN, TNF
21corticosterone44 59 2411.1IL1B, IL1RN, IL1R1
22cicaprost44 2810.0TNF, IL1B
23fibrinogen448.9TNF, IL1RN, IL1R1, MBL2
24acth448.9MC1R, IL1RN, IL1R1, IL1B
25rosiglitazone44 49 28 11 2412.9TNF, IL1RN, IL1R1
26polymyxin b448.9IL1B, IL1RN, TNF, MBL2
27gold sodium thiomalate448.8IL1R1, IL1B, TNF, IL1RN
28sulfasalazine44 28 49 1111.8IL1RN, IL1B, TNF, IL1R1
29etanercept44 49 1110.8TNF, IL1RN, IL1R1, IL1B
30il 10448.8IL1RN, IL1B, IL1R1, TNF
31infliximab44 49 1110.8IL1R1, IL1B, IL1RN, TNF
32ivig448.8IL1B, IL1R1, IL1RN, TNF
33leukotriene b444 59 2410.8IL1R1, IL1RN, TNF, IL1B
34mifepristone44 59 28 1111.8ESR1, IL1R1, IL1B
35prostaglandin448.8IL1R1, IL1B, IL1RN, TNF
36indomethacin44 59 28 1111.7IL1RN, TNF, IL1R1, IL1B
37sb 20358044 599.7IL1RN, TNF, IL1B, IL1R1
38superoxide44 249.5MBL2, IL1B, IL1RN, TNF
39lipoteichoic acid448.5TNF, MBL2, IL1B, IL1R1, IL1RN
40peptidoglycan44 289.5TNF, IL1R1, IL1B, MBL2, IL1RN
41neopterin448.5IL1RN, MBL2, TNF, IL1R1, IL1B
42rantes448.4TNF, IL1RN, MBL2, IL1R1, IL1B
43anakinra44 119.4TNF, IL1RN, IL1R1, IL1B, NLRP3
44dexamethasone44 49 28 1111.4MBL2, IL1RN, IL1B, IL1R1, TNF
45actinomycin d448.4ESR1, IL1B, IL1R1, TNF
46nitric oxide44 11 2410.3IL1RN, TNF, IL1R1, MBL2, IL1B
47leflunomide49 44 1110.0IL1RN, ESR1, IL1B, IL1R1, TNF
48retinoic acid44 248.8TNF, ESR1, IL1RN, IL1R1, IL1B
49vegf447.6IL1R1, IL1RN, IL1B, TNF, ESR1, MBL2
50methotrexate44 49 119.6NLRP3, ESR1, TNF, IL1B, IL1R1, IL1RN

GO Terms for genes affiliated with Vulvar Vestibulitis Syndrome

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16Gene Ontology
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Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4IL1B, IL1RN, TNF, MBL2

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:0441309.9TNF, MBL2
2chronic inflammatory response to antigenic stimulusGO:0024399.8IL1RN, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IL1B
4sequestering of triglycerideGO:0307309.7TNF, IL1B
5positive regulation of heterotypic cell-cell adhesionGO:0341169.7IL1B, TNF
6positive regulation of fever generationGO:0316229.7IL1B, TNF
7positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, TNF
8positive regulation of JUN kinase activityGO:0435079.7TNF, IL1RN
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7TNF, IL1B
10positive regulation of membrane protein ectodomain proteolysisGO:0510449.6IL1B, TNF
11negative regulation of lipid catabolic processGO:0509959.6IL1B, TNF
12positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
13negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
14defense response to Gram-positive bacteriumGO:0508309.6TNF, MBL2
15positive regulation of mitosisGO:0458409.6TNF, IL1B
16positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.6TNF, NLRP3
17lipopolysaccharide-mediated signaling pathwayGO:0316639.5TNF, IL1B
18cellular response to organic cyclic compoundGO:0714079.5IL1B, TNF
19acute-phase responseGO:0069539.5MBL2, IL1RN
20protein kinase B signaling cascadeGO:0434919.5TNF, IL1B
21positive regulation of interferon-gamma productionGO:0327299.4IL1B, TNF
22positive regulation of NF-kappaB transcription factor activityGO:0510929.2IL1B, TNF, NLRP3
23positive regulation of interleukin-6 productionGO:0327559.0IL1B, TNF
24positive regulation of nitric oxide biosynthetic processGO:0454298.9ESR1, IL1B, TNF
25inflammatory responseGO:0069548.9IL1B, TNF, NLRP3
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9TNF, IL1B, ESR1
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, MC1R, IL1B, ESR1

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.3IL1B, IL1RN

Products for genes affiliated with Vulvar Vestibulitis Syndrome

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Sources for Vulvar Vestibulitis Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet