MCID: VLV011
MIFTS: 64

Vulvovaginal Candidiasis malady

Infectious diseases, Reproductive diseases categories

Summaries for Vulvovaginal Candidiasis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. the cervix has a small opening that expands during childbirth. it also allows menstrual blood to leave a woman's body. your health care provider may perform a pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. other problems with the cervix include: cervicitis - inflammation of the cervix. this is usually from an infection. cervical incompetence - this can happen during pregnancy. the opening of the cervix widens long before the baby is due. cervical polyps and cysts - abnormal growths on the cervix

MalaCards: Vulvovaginal Candidiasis, also known as candidiasis of vulva and vagina, is related to candidiasis and adenocarcinoma. An important gene associated with Vulvovaginal Candidiasis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Spinal Cord Injury and Beta defensins. The drugs clotrimazole and fluconazole and the compounds prednisolone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related mouse phenotypes are renal/urinary system and reproductive system.

Disease Ontology:8 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by candida albicans. the symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

Wikipedia:63 Candidal vulvovaginitis or vaginal thrush is an infection of the vagina’s mucous membranes by Candida... more...

Aliases & Classifications for Vulvovaginal Candidiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

vulvovaginal candidiasis 8 10
candidiasis of vulva and vagina 8
candidal: vulvovaginitis nos 8
candidal vulvovaginitis nos 8
candidiasis, vulvovaginal 60
candidiasis vulvovaginal 44
monilial vulvovaginitis 8
candidal vulvovaginitis 8
cervix disorders 33
cervix diseases 60
cervix disease 8
cervix 8


Related Diseases for Vulvovaginal Candidiasis

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17GeneCards, 18GeneDecks
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Diseases related to Vulvovaginal Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.0SKAP2, IFNG, DEFB4A, CD79A
2adenocarcinoma31.4LAP3, GGT1
3oral candidiasis31.2DEFB4A, SKAP2
4bacterial vaginosis30.8MBL2, LAP3
5cervical cancer30.7MBL2
6adenoma30.5GGT1
7diabetes mellitus30.4GGT1, CD79A
8melanoma30.2IFNG, IL4, IL2, LAP3
9cystic fibrosis30.2MBL2, DEFB1, DEFB4A, LAP3
10deficiency anemia30.1F2, IL2, CD79A
11plasmacytoma29.9CD79A
12prostatitis29.9CD79A
13thyroiditis29.9CD79A, MBL2
14lung cancer29.9IL2
15arthropathy29.8IL1RN, NLRP3
16tuberculosis29.8IL2, IL4, CD79A, DEFB4A, MBL2, IFNG
17pancreatitis29.6GGT1
18herpes simplex29.6CD79A
19nephrotic syndrome29.6CD79A
20macroglobulinemia29.6CD79A
21urethritis29.6CD79A
22meningitis29.6CD79A, MBL2
23colorectal cancer29.6IL2
24acute leukemia29.6IL2
25ovarian cancer29.6IL2
26vaccinia29.6IL2
27vasculitis29.6MBL2, CD79A, F2
28hypertension29.6CD79A, F2, GGT1
29stomach cancer29.6MBL2, DEFB4A, IL1RN
30schistosomiasis29.6IL4, CD79A, IFNG
31arthritis29.6NLRP3, IFNG, IL1RN, IL4
32leukemia29.6IFNG, MBL2, CD79A, IL4, IL2
33vulvovaginitis11.4
34vaginitis10.9
35squamous cell carcinoma10.8
36adenocarcinoma in situ10.7
37cervicitis10.7
38cervix small cell carcinoma10.6
39small cell carcinoma10.6
40clear cell adenocarcinoma10.6
41in situ carcinoma10.6
42neuroendocrine carcinoma10.6
43adenosquamous carcinoma10.5
44papillary adenocarcinoma10.5
45rhabdomyosarcoma10.5
46sarcoma10.4
47adenosarcoma10.4
48verrucous carcinoma10.4
49cervical squamous cell carcinoma10.4
50cervical adenocarcinoma10.4

Graphical network of the top 20 diseases related to Vulvovaginal Candidiasis:



Diseases related to vulvovaginal candidiasis

Clinical Features for Vulvovaginal Candidiasis

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Drugs & Therapeutics for Vulvovaginal Candidiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vulvovaginal Candidiasis

Drug clinical trials:

Search ClinicalTrials for Vulvovaginal Candidiasis

Search NIH Clinical Center for Vulvovaginal Candidiasis

Search CenterWatch for Vulvovaginal Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Vulvovaginal Candidiasis

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Anatomical Context for Vulvovaginal Candidiasis

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32MalaCards
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MalaCards organs/tissues related to Vulvovaginal Candidiasis:

32
Cervix, Testes, Uterus, Colon, B cells

Animal Models for Vulvovaginal Candidiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vulvovaginal Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1NLRP3
2MP:00053899.5NLRP3, IL1RN
3MP:00107719.0GGT1, F2, NLRP3
4MP:00053766.9NLRP3, IFNG, MBL2, CD79A, IL1RN, IL4
5MP:00053976.5CD79A, MBL2, IFNG, NLRP3, IL1RN, IL4
6MP:00053875.6LAP3, NLRP3, IFNG, MBL2, DEFB1, CD79A

Publications for Vulvovaginal Candidiasis

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Sources:
50PubMed
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Articles related to Vulvovaginal Candidiasis:

(show top 50)    (show all 306)
idTitleAuthorsYear
1
Evaluation of Mucoadhesive Gels with Propolis (EPP-AF) in Preclinical Treatment of Candidiasis Vulvovaginal Infection. (23997797)
2013
2
Chronic vulvovaginal candidiasis: what we know and what we have yet to learn. (22998230)
2012
3
Electromyography and vaginal pressure of the pelvic floor muscles in women with recurrent vulvovaginal candidiasis and vulvodynia. (22523874)
2012
4
Assessment of in vitro biofilm formation by Candida species isolates from vulvovaginal candidiasis and ultrastructural characteristics. (22001373)
2012
5
Epidemiologic features of Vulvovaginal Candidiasis among reproductive-age women in India. (23118494)
2012
6
Microsatellite analysis of Candida isolates from recurrent vulvovaginal candidiasis. (22538998)
2012
7
Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and I+-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-I_B activation. (21830186)
2011
8
Prevalence of bacterial vaginosis and vulvovaginal candidiasis mixed infection in a southeastern american STD clinic. (21844715)
2011
9
The epidemiology of Candida species associated with vulvovaginal candidiasis in an Iranian patient population. (21194828)
2011
10
Vulvovaginal candidiasis in postmenopausal women: the role of hormone replacement therapy. (21959570)
2011
11
Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China. (20516286)
2010
12
Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. (19187507)
2009
13
Vulvovaginal candidiasis: diagnostic and therapeutic approaches used by Dutch general practitioners. (18464170)
2008
14
Vulvovaginal candidiasis in women who have sex with women. (18418293)
2008
15
Study on vaginal production of human defensins and the correlated pathogenetic factors of vulvovaginal candidiasis]. (19080508)
2008
16
Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis. (18715406)
2008
17
Vulvovaginal candidiasis and its related factors in diabetic women. (18182346)
2007
18
An epidemiological study of vulvovaginal candidiasis in women of childbearing age. (17582200)
2007
19
Comprehensive review of conventional and non-conventional methods of management of recurrent vulvovaginal candidiasis. (17627679)
2007
20
Clinical aspects and luteal phase assessment in patients with recurrent vulvovaginal candidiasis. (16687200)
2007
21
Perceived stress in women with recurrent vulvovaginal candidiasis. (17577760)
2007
22
Fluconazole versus 3-day clotrimazole in the treatment of sporadic and recurrent vulvovaginal candidiasis. (16916515)
2006
23
Recurrent vulvovaginal candidiasis. (16703718)
2006
24
Terbinafine versus itraconazole and fluconazole in the treatment of Vulvovaginal candidiasis. (16858169)
2006
25
Does lactobacillus prevent post-antibiotic vulvovaginal candidiasis? (16225781)
2005
26
Vulvovaginal candidiasis is associated with the production of germ tubes by Candida albicans. (15983735)
2005
27
An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis. (15102806)
2004
28
Vulvovaginal candidiasis. (14719844)
2003
29
Itraconazole (SporanoxAr) for vulvovaginal candidiasis. (12432422)
2002
30
Vulvovaginal candidiasis: a comparison of HIV-positive and -negative women. (12015006)
2002
31
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). (11687165)
2001
32
Increased incidence of vulvovaginal candidiasis caused by Candida glabrata in Jordan. (11544399)
2001
33
Single-dose miconazole nitrate vaginal ovule in the treatment of vulvovaginal candidiasis: two single-blind, controlled studies versus miconazole nitrate 100 mg cream for 7 days. (10868615)
2000
34
Treatment of recurrent vulvovaginal candidiasis. (10865926)
2000
35
What to do with the patient with recurrent vulvovaginal candidiasis. (10615306)
1999
36
Clinical and cost considerations in the pharmacotherapy of vulvovaginal candidiasis. (10160477)
1996
37
Immunopathogenesis of recurrent vulvovaginal candidiasis. (8809464)
1996
38
The impact of oral contraception on vulvovaginal candidiasis. (7628203)
1995
39
Vulvovaginal candidiasis. (7993497)
1994
40
Clinical and microbiological characteristics of symptomatic vulvovaginal candidiasis in HIV-seropositive women. (7959713)
1994
41
Pathogenesis and treatment of recurrent vulvovaginal candidiasis. (1562688)
1992
42
Efficacy and tolerance of local treatment of acute vulvovaginal candidiasis with 4 different single doses (10, 25, 50 and 100 mg) of Ro 14-4767 versus a 7-day treatment with miconazole. (16312711)
1989
43
Phase II study of D.651, an oral vaccine designed to prevent recurrences of vulvovaginal candidiasis. (2683457)
1989
44
Pathogenesis and epidemiology of vulvovaginal candidiasis. (3063184)
1988
45
Vulvovaginal candidiasis: a symposium. (3735269)
1986
46
Three-day treatment with butoconazole vaginal suppositories for vulvovaginal candidiasis. (3514908)
1986
47
Recurrent vulvovaginal candidiasis. A prospective study of the efficacy of maintenance ketoconazole therapy. (3537785)
1986
48
Vulvovaginal candidiasis--what we do and do not know. (6087707)
1984
49
Clotrimazole for vulvovaginal candidiasis. Report of double-blind study. (331156)
1977
50
Monistat cream (miconazole nitrate) a new agent for the treatment of vulvovaginal candidiasis. (765457)
1975

Genetic Variations for Vulvovaginal Candidiasis

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Expression for genes affiliated with Vulvovaginal Candidiasis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvovaginal Candidiasis

Search GEO for disease gene expression data for Vulvovaginal Candidiasis.

Pathways for genes affiliated with Vulvovaginal Candidiasis

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Sources:
37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL4, IL2
2
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9.4DEFB4A, DEFB1, DEFA5
3
Immune response Bacterial infections in normal airways
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9.4IFNG, DEFB4A, IL1RN
4
Development Thrombopoetin signaling via JAK-STAT pathway
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9.3IL4, IL1RN, IFNG
5
Development PDGF signaling via STATs and NF-kB
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9.3F2, IL2, IFNG
69.3IL2, IL4, IFNG
79.3IL2, IL4, IFNG
8
Hide members
9.3IL2, IL4, IFNG
99.3IL2, IL4, IFNG
10
Hide members
9.3IL2, IL4, IFNG
119.3IFNG, IL4, IL2
129.3IFNG, IL4, IL2
13
Hide members
9.0IL2, IL4, IFNG, NLRP3
14
Hide members
9.0IFNG, CD79A, IL4, IL2
15
Hide members
9.0IFNG, CD79A, IL4, IL2
16
Hide members
9.0IFNG, CD79A, IL4, IL2
178.9GGT1, F2, IFNG
18
Hide members
7.4IL2, NLRP3, IFNG, MBL2, DEFA5, DEFB1

Compounds for genes affiliated with Vulvovaginal Candidiasis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.4CD79A, MBL2
2gm-csf44 2811.2IFNG
3indomethacin44 59 28 1113.1GGT1
4pge24410.1IL2
5gamma globulin4410.0GGT1
6tdac4410.0IL4, IL2
7tuberculin449.8CD79A, MBL2, IFNG
8cyclosporin a44 28 5911.8IFNG, CD79A, F2
9hbd2449.8DEFA5, DEFB1, DEFB4A
10clarithromycin44 1110.8F2, IL1RN, CD79A
11bucillamine449.7IFNG, IL2, CD79A
12lipoteichoic acid449.7DEFB4A, IL1RN, MBL2
13interferon gamma449.7IFNG, IL4, IL2
14alpha-galactosylceramide449.6IL2, IFNG, IL4
15adalimumab44 49 1111.6CD79A, IFNG, IL1RN
16glatiramer acetate44 1110.6IL2, IL4, IFNG
17amphotericin b449.6IL4, IL1RN, IFNG
18gold sodium thiomalate449.6IL1RN, IFNG, IL2
19il-12449.5IL4, IFNG, IL2
20polyethylene glycol449.5IL4, IL1RN, F2, CD79A
21mannose449.4CD79A, IL1RN, MBL2, DEFB4A
22okt3449.4IFNG, IL2, IL4, CD79A
23ivig449.4IL4, IL1RN, CD79A, IFNG
24chloroquine44 2 49 28 1113.4IL1RN, IL2, IL4, CD79A
25allergens449.4IL4, IL1RN, CD79A, IFNG
26pentoxifylline44 1110.4GGT1, IL4, IL1RN
27praziquantel44 1110.3IL4, CD79A, GGT1
28il 10449.3IL2, IL4, IL1RN, IFNG
29dexamethasone44 49 28 1112.3DEFB1, DEFB4A, CD79A, GGT1
30polymyxin b449.3IFNG, MBL2, DEFB1, IL1RN, IL4
31simvastatin44 49 59 28 11 2414.2IL4, IFNG, F2, IL1RN
32rantes449.2IL2, IL4, DEFB4A, MBL2, IFNG
33con a449.2MBL2, IFNG, IL2, CD79A, IL4
34anti-fungal449.1SKAP2, CD79A, DEFB4A, MBL2, IFNG
35p-nitroaniline449.1LAP3, GGT1
36thyroxine44 2410.0MBL2, GGT1, IL4, CD79A
37polyinosinic-polycytidylic acid449.0IL4, IL2, IFNG
38calcitriol44 59 11 2411.9IL2, IL4, IFNG, F2
39mycophenolate mofetil44 49 1110.9CD79A, IL2, IFNG, GGT1
40azathioprine44 49 2 1111.9IL4, GGT1, CD79A, IL2
41hyaluronic acid44 249.9IL1RN, F2, GGT1, CD79A
42neopterin448.8IL2, IL4, IL1RN, CD79A, MBL2, IFNG
43methotrexate44 49 1110.8F2, IL1RN, NLRP3, CD79A, GGT1
44histamine44 28 2410.7IL4, IL2, IL1RN, CD79A, DEFB4A, IFNG
45ribavirin44 49 1110.6IL4, IL2, GGT1, MBL2, IFNG
46tacrolimus44 49 1110.5IL2, IFNG, IL4, CD79A, GGT1
47creatinine448.2LAP3, GGT1, MBL2, F2, IL1RN, CD79A
48vegf448.1IL4, MBL2, CD79A, IL2, IFNG, IL1RN
49lactate447.9CD79A, LAP3, IL1RN, GGT1, F2
50cysteine447.5IL4, IL1RN, CD79A, DEFB4A, MBL2, IFNG

GO Terms for genes affiliated with Vulvovaginal Candidiasis

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Sources:
16Gene Ontology
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Cellular components related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.8DEFA5, DEFB1, DEFB4A, F2
2extracellular regionGO:0055768.0F2, IL2, DEFB4A, DEFB1, DEFA5, MBL2
3extracellular spaceGO:0056157.7F2, IL2, IL4, IL1RN, DEFA5, MBL2

Biological processes related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.0NLRP3, IL4
2positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
3negative regulation of growth of symbiont in hostGO:0441309.8IFNG, MBL2
4positive regulation of chemokine biosynthetic processGO:0450809.8IL4, IFNG
5acute-phase responseGO:0069539.8F2, IL1RN, MBL2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL2, IL4
7chemotaxisGO:0069359.7IL4, DEFB4A, DEFB1
8positive regulation of activated T cell proliferationGO:0421049.7IL2, IL4
9defense response to protozoanGO:0428329.6IL4, IFNG
10positive regulation of isotype switching to IgG isotypesGO:0483049.5IFNG, IL4, IL2
11positive regulation of interleukin-1 beta secretionGO:0507189.4IFNG, NLRP3
12innate immune responseGO:0450879.1NLRP3, MBL2, DEFA5, DEFB1, DEFB4A
13immune responseGO:0069559.1DEFB1, DEFB4A, IL1RN, IL4, IL2
14defense response to bacteriumGO:0427429.0DEFB4A, DEFB1, DEFA5, MBL2, IFNG

Products for genes affiliated with Vulvovaginal Candidiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vulvovaginal Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet