MCID: VLV011
MIFTS: 64

Vulvovaginal Candidiasis malady

Infectious diseases, Reproductive diseases categories

Summaries for Vulvovaginal Candidiasis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. the cervix has a small opening that expands during childbirth. it also allows menstrual blood to leave a woman's body. your health care provider may perform a pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. other problems with the cervix include: cervicitis - inflammation of the cervix. this is usually from an infection. cervical incompetence - this can happen during pregnancy. the opening of the cervix widens long before the baby is due. cervical polyps and cysts - abnormal growths on the cervix

MalaCards: Vulvovaginal Candidiasis, also known as candidiasis of vulva and vagina, is related to candidiasis and adenocarcinoma. An important gene associated with Vulvovaginal Candidiasis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Spinal Cord Injury and Beta defensins. The drugs clotrimazole and fluconazole and the compounds prednisolone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related mouse phenotypes are renal/urinary system and reproductive system.

Disease Ontology:8 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by candida albicans. the symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

Wikipedia:63 Candidal vulvovaginitis or vaginal thrush is an infection of the vagina’s mucous membranes by Candida... more...

Aliases & Classifications for Vulvovaginal Candidiasis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

vulvovaginal candidiasis 8 10
candidiasis of vulva and vagina 8
candidal: vulvovaginitis nos 8
candidal vulvovaginitis nos 8
candidiasis, vulvovaginal 60
candidiasis vulvovaginal 44
monilial vulvovaginitis 8
candidal vulvovaginitis 8
cervix disorders 33
cervix diseases 60
cervix disease 8
cervix 8


Related Diseases for Vulvovaginal Candidiasis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vulvovaginal Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.0SKAP2, IFNG, DEFB4A, CD79A
2adenocarcinoma31.4LAP3, GGT1
3oral candidiasis31.2DEFB4A, SKAP2
4bacterial vaginosis30.8MBL2, LAP3
5cervical cancer30.7MBL2
6adenoma30.5GGT1
7diabetes mellitus30.4GGT1, CD79A
8melanoma30.2IFNG, IL4, IL2, LAP3
9cystic fibrosis30.2MBL2, DEFB1, DEFB4A, LAP3
10deficiency anemia30.1F2, IL2, CD79A
11plasmacytoma29.9CD79A
12prostatitis29.9CD79A
13thyroiditis29.9CD79A, MBL2
14lung cancer29.9IL2
15arthropathy29.8IL1RN, NLRP3
16tuberculosis29.8IL2, IL4, CD79A, DEFB4A, MBL2, IFNG
17pancreatitis29.6GGT1
18herpes simplex29.6CD79A
19nephrotic syndrome29.6CD79A
20macroglobulinemia29.6CD79A
21urethritis29.6CD79A
22meningitis29.6CD79A, MBL2
23colorectal cancer29.6IL2
24acute leukemia29.6IL2
25ovarian cancer29.6IL2
26vaccinia29.6IL2
27vasculitis29.6MBL2, CD79A, F2
28hypertension29.6CD79A, F2, GGT1
29stomach cancer29.6MBL2, DEFB4A, IL1RN
30schistosomiasis29.6IL4, CD79A, IFNG
31arthritis29.6NLRP3, IFNG, IL1RN, IL4
32leukemia29.6IFNG, MBL2, CD79A, IL4, IL2
33vulvovaginitis11.4
34vaginitis10.9
35squamous cell carcinoma10.8
36adenocarcinoma in situ10.7
37cervicitis10.7
38cervix small cell carcinoma10.6
39small cell carcinoma10.6
40clear cell adenocarcinoma10.6
41in situ carcinoma10.6
42neuroendocrine carcinoma10.6
43adenosquamous carcinoma10.5
44papillary adenocarcinoma10.5
45rhabdomyosarcoma10.5
46sarcoma10.4
47adenosarcoma10.4
48verrucous carcinoma10.4
49cervical squamous cell carcinoma10.4
50cervical adenocarcinoma10.4

Graphical network of the top 20 diseases related to Vulvovaginal Candidiasis:



Diseases related to vulvovaginal candidiasis

Clinical Features for Vulvovaginal Candidiasis

About this section

Drugs & Therapeutics for Vulvovaginal Candidiasis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vulvovaginal Candidiasis

Drug clinical trials:

Search ClinicalTrials for Vulvovaginal Candidiasis

Search NIH Clinical Center for Vulvovaginal Candidiasis

Search CenterWatch for Vulvovaginal Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Vulvovaginal Candidiasis

About this section

Anatomical Context for Vulvovaginal Candidiasis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Vulvovaginal Candidiasis:

32
Cervix, Testes, Uterus, Colon, B cells

Animal Models for Vulvovaginal Candidiasis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Vulvovaginal Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1NLRP3
2MP:00053899.5NLRP3, IL1RN
3MP:00107719.0GGT1, F2, NLRP3
4MP:00053766.9NLRP3, IFNG, MBL2, CD79A, IL1RN, IL4
5MP:00053976.5CD79A, MBL2, IFNG, NLRP3, IL1RN, IL4
6MP:00053875.6LAP3, NLRP3, IFNG, MBL2, DEFB1, CD79A

Publications for Vulvovaginal Candidiasis

About this section
Sources:
50PubMed
See all sources

Articles related to Vulvovaginal Candidiasis:

(show top 50)    (show all 306)
idTitleAuthorsYear
1
Immune deviation in recurrent vulvovaginal candidiasis: correlation with iron deficiency anemia. (23811551)
2013
2
Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences. (24146467)
2013
3
NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response. (24063977)
2013
4
Lactobacillus helveticus HY7801 ameliorates vulvovaginal candidiasis in mice by inhibiting fungal growth and NF-I_B activation. (22735758)
2012
5
Use of complementary and alternative medicine in recurrent vulvovaginal candidiasis--results of a practitioner survey. (22579433)
2012
6
Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product, in women affected by vulvovaginal candidiasis: a pilot study. (22955364)
2012
7
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
8
Antifungal efficacy of propolis against fluconazole-resistant Candida glabrata isolates obtained from women with recurrent vulvovaginal candidiasis. (21669419)
2011
9
Diagnostic techniques for bacterial vaginosis and vulvovaginal candidiasis - requirement for a simple differential test. (23496149)
2010
10
Reduced fluconazole susceptibility of Candida albicans isolates in women with recurrent vulvovaginal candidiasis: effects of long-term fluconazole therapy. (19501794)
2009
11
Relationship between clinical diagnosis of recurrent vulvovaginal candidiasis and detection of Candida species by culture and polymerase chain reaction. (18506464)
2009
12
Efficient diagnosis of vulvovaginal candidiasis by use of a new rapid immunochromatography test. (19794036)
2009
13
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
14
Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. (17470593)
2007
15
Glucose in vaginal secretions before and after oral glucose tolerance testing in women with and without recurrent vulvovaginal candidiasis. (17138777)
2006
16
Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis. (15830422)
2005
17
Recurrent vulvovaginal candidiasis. (16265812)
2005
18
Safety and efficacy of bedtime versus daytime administration of the miconazole nitrate 1200 mg vaginal ovule insert to treat vulvovaginal candidiasis. (15881484)
2005
19
Recurrent vulvovaginal candidiasis. (15799663)
2005
20
Current treatment options for vulvovaginal candidiasis. (19803842)
2005
21
Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. (15329425)
2004
22
IgA, IgE and IgG subclasses to Candida albicans in serum and vaginal fluid from patients with vulvovaginal candidiasis]. (14963598)
2003
23
Vulvovaginal candidiasis. (12228137)
2002
24
Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis. (12151172)
2002
25
Drugs for vulvovaginal candidiasis. (11151090)
2001
26
Measurement of T-cell-derived antigen binding molecules and immunoglobulin G specific to Candida albicans mannan in sera of patients with recurrent vulvovaginal candidiasis. (10858192)
2000
27
Determinants of incident vulvovaginal candidiasis in human immunodeficiency virus-positive women. (10968602)
2000
28
The study of cell-mediated immune response in recurrent vulvovaginal candidiasis. (11024346)
2000
29
Recurrent vulvovaginal candidiasis: why does it occur? (10454177)
1999
30
Vulvovaginal candidiasis in female sex workers. (9764936)
1998
31
Once-daily fluocinonide-bifonazole combination for the treatment of vulvar itching and vulvovaginal candidiasis. Preliminary study. (8894328)
1996
32
Detection of anti-Candida albicans IgE antibodies in vaginal washes from patients with acute vulvovaginal candidiasis. (8150365)
1994
33
Application of biotyping and DNA typing of Candida albicans to the epidemiology of recurrent vulvovaginal candidiasis. (8101553)
1993
34
Vulvovaginal candidiasis refractory to treatment with fluconazole. (1587371)
1992
35
Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison. (1941796)
1991
36
Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis. (1877264)
1991
37
Vulvovaginal candidiasis complicating recurrent bacterial vaginosis. (2305336)
1990
38
Comparison of 0.8% and 1.6% terconazole cream in severe vulvovaginal candidiasis. (2381618)
1990
39
A comparison of butoconazole nitrate cream with econazole nitrate cream for the treatment of vulvovaginal candidiasis. (2257961)
1990
40
Terconazole for the treatment of vulvovaginal candidiasis. (2277372)
1990
41
Comparison of three-day butoconazole treatment with seven-day miconazole treatment for vulvovaginal candidiasis. (2671362)
1989
42
Papers selected from presentations given at the symposium "Vulvovaginal Candidiasis: Current Views". January 10-11, 1987. (3364510)
1988
43
Three-day treatment of vulvovaginal candidiasis. (3364485)
1988
44
Depo-Provera in the treatment of recurrent vulvovaginal candidiasis. (2945926)
1986
45
A comparison of the efficacy of two vaginal creams for vulvovaginal candidiasis, and correlations with the presence of Candida species in the perianal area and oral contraceptive use. (6347382)
1983
46
A three-day treatment regimen for vulvovaginal candidiasis. (6750015)
1982
47
Treatment of vulvovaginal candidiasis with boric acid powder. (7282789)
1981
48
Miconazole in the treatment of vulvovaginal candidiasis: comparison of a 6-day therapy and a 3-day treatment course. (7189485)
1980
49
Trichomoniasis and candidiasis vulvovaginitis. Procedures that most frequently result in permanent cures and prevent thrush in newborn infants. (13733397)
1960
50
The clinical use of Taschdjian's medium in the diagnosis of vulvovaginal candidiasis. (13837061)
1960

Genetic Variations for Vulvovaginal Candidiasis

About this section

Expression for genes affiliated with Vulvovaginal Candidiasis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vulvovaginal Candidiasis

Search GEO for disease gene expression data for Vulvovaginal Candidiasis.

Pathways for genes affiliated with Vulvovaginal Candidiasis

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 51QIAGEN
See all sources

Pathways related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL4, IL2
2
Hide members
9.4DEFB4A, DEFB1, DEFA5
3
Immune response Bacterial infections in normal airways
Hide members
9.4IFNG, DEFB4A, IL1RN
4
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.3IL4, IL1RN, IFNG
5
Development PDGF signaling via STATs and NF-kB
Hide members
9.3F2, IL2, IFNG
69.3IL2, IL4, IFNG
79.3IL2, IL4, IFNG
8
Hide members
9.3IL2, IL4, IFNG
99.3IL2, IL4, IFNG
10
Hide members
9.3IL2, IL4, IFNG
119.3IFNG, IL4, IL2
129.3IFNG, IL4, IL2
13
Hide members
9.0IL2, IL4, IFNG, NLRP3
14
Hide members
9.0IFNG, CD79A, IL4, IL2
15
Hide members
9.0IFNG, CD79A, IL4, IL2
16
Hide members
9.0IFNG, CD79A, IL4, IL2
178.9GGT1, F2, IFNG
18
Hide members
7.4IL2, NLRP3, IFNG, MBL2, DEFA5, DEFB1

Compounds for genes affiliated with Vulvovaginal Candidiasis

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.4CD79A, MBL2
2gm-csf44 2811.2IFNG
3indomethacin44 59 28 1113.1GGT1
4pge24410.1IL2
5gamma globulin4410.0GGT1
6tdac4410.0IL4, IL2
7tuberculin449.8IFNG, MBL2, CD79A
8cyclosporin a44 28 5911.8IFNG, CD79A, F2
9hbd2449.8DEFA5, DEFB1, DEFB4A
10clarithromycin44 1110.7CD79A, IL1RN, F2
11bucillamine449.7IFNG, CD79A, IL2
12lipoteichoic acid449.7IL1RN, DEFB4A, MBL2
13interferon gamma449.7IFNG, IL4, IL2
14alpha-galactosylceramide449.7IFNG, IL4, IL2
15adalimumab44 49 1111.6IL1RN, CD79A, IFNG
16glatiramer acetate44 1110.6IFNG, IL4, IL2
17amphotericin b449.6IFNG, IL1RN, IL4
18gold sodium thiomalate449.6IFNG, IL1RN, IL2
19il-12449.5IFNG, IL4, IL2
20polyethylene glycol449.5F2, IL4, IL1RN, CD79A
21mannose449.4MBL2, DEFB4A, CD79A, IL1RN
22okt3449.4IFNG, CD79A, IL4, IL2
23ivig449.4IL4, IL1RN, CD79A, IFNG
24chloroquine44 2 49 28 1113.4IL2, IL4, IL1RN, CD79A
25allergens449.4IFNG, CD79A, IL1RN, IL4
26pentoxifylline44 1110.4IL1RN, IL4, GGT1
27praziquantel44 1110.3CD79A, IL4, GGT1
28il 10449.3IFNG, IL1RN, IL4, IL2
29dexamethasone44 49 28 1112.3DEFB1, DEFB4A, CD79A, GGT1
30polymyxin b449.3IFNG, MBL2, DEFB1, IL1RN, IL4
31simvastatin44 49 59 28 11 2414.2F2, IL4, IL1RN, IFNG
32rantes449.2IL2, IL4, DEFB4A, MBL2, IFNG
33con a449.2IFNG, MBL2, CD79A, IL4, IL2
34anti-fungal449.1IFNG, MBL2, DEFB4A, CD79A, SKAP2
35p-nitroaniline449.1LAP3, GGT1
36thyroxine44 2410.0MBL2, CD79A, IL4, GGT1
37polyinosinic-polycytidylic acid449.0IFNG, IL4, IL2
38calcitriol44 59 11 2411.9F2, IL2, IL4, IFNG
39mycophenolate mofetil44 49 1110.9GGT1, IL2, CD79A, IFNG
40azathioprine44 49 2 1111.9CD79A, IL4, IL2, GGT1
41hyaluronic acid44 249.9CD79A, IL1RN, F2, GGT1
42neopterin448.8IL2, IL4, IL1RN, CD79A, MBL2, IFNG
43methotrexate44 49 1110.8GGT1, F2, IL1RN, CD79A, NLRP3
44histamine44 28 2410.7IFNG, DEFB4A, CD79A, IL1RN, IL4, IL2
45ribavirin44 49 1110.6GGT1, IL2, IL4, MBL2, IFNG
46tacrolimus44 49 1110.5IFNG, CD79A, IL4, IL2, GGT1
47creatinine448.2MBL2, CD79A, IL1RN, F2, GGT1, LAP3
48vegf448.1IFNG, MBL2, CD79A, IL1RN, IL4, IL2
49lactate447.9LAP3, GGT1, F2, IL1RN, CD79A
50cysteine447.5IFNG, MBL2, DEFB4A, CD79A, IL1RN, IL4

GO Terms for genes affiliated with Vulvovaginal Candidiasis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.8DEFA5, DEFB1, DEFB4A, F2
2extracellular regionGO:0055768.0F2, IL2, DEFB4A, DEFB1, DEFA5, MBL2
3extracellular spaceGO:0056157.7F2, IL2, IL4, IL1RN, DEFA5, MBL2

Biological processes related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.0NLRP3, IL4
2positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
3negative regulation of growth of symbiont in hostGO:0441309.8IFNG, MBL2
4positive regulation of chemokine biosynthetic processGO:0450809.8IL4, IFNG
5acute-phase responseGO:0069539.8F2, IL1RN, MBL2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL2, IL4
7chemotaxisGO:0069359.7IL4, DEFB4A, DEFB1
8positive regulation of activated T cell proliferationGO:0421049.7IL2, IL4
9defense response to protozoanGO:0428329.6IL4, IFNG
10positive regulation of isotype switching to IgG isotypesGO:0483049.5IFNG, IL4, IL2
11positive regulation of interleukin-1 beta secretionGO:0507189.4IFNG, NLRP3
12innate immune responseGO:0450879.1NLRP3, MBL2, DEFA5, DEFB1, DEFB4A
13immune responseGO:0069559.1DEFB1, DEFB4A, IL1RN, IL4, IL2
14defense response to bacteriumGO:0427429.0DEFB4A, DEFB1, DEFA5, MBL2, IFNG

Products for genes affiliated with Vulvovaginal Candidiasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vulvovaginal Candidiasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet