MCID: VLV011
MIFTS: 56

Vulvovaginal Candidiasis malady

Infectious diseases, Reproductive diseases categories

Summaries for Vulvovaginal Candidiasis

About this section


MedlinePlus:32 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. the cervix has a small opening that expands during childbirth. it also allows menstrual blood to leave a woman's body. your health care provider may perform a pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. other problems with the cervix include: cervicitis - inflammation of the cervix. this is usually from an infection. cervical incompetence - this can happen during pregnancy. the opening of the cervix widens long before the baby is due. cervical polyps and cysts - abnormal growths on the cervix

MalaCards based summary: Vulvovaginal Candidiasis, also known as candidiasis of vulva and vagina, is related to candidiasis and bacterial vaginosis. An important gene associated with Vulvovaginal Candidiasis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The drugs miconazole and miconazole nitrate pwdr and the compounds tuberculin and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:9 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by candida albicans. the symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

CDC:3 Genital / vulvovaginal candidiasis (VVC) is also sometimes called a "yeast infection," and it occurs when there is overgrowth of the normal yeast in the vagina. This infection is relatively common -- nearly 75% of all adult women have had at least one "yeast infection" in their lifetime.

Wikipedia:63 Candidal vulvovaginitis, also known as a vaginal yeast infection and vaginal thrush, is excessive growth... more...

Aliases & Classifications for Vulvovaginal Candidiasis

About this section

Vulvovaginal Candidiasis, Aliases & Descriptions:

Name: Vulvovaginal Candidiasis 9 11 3
Candidiasis of Vulva and Vagina 9
Candidal: Vulvovaginitis Nos 9
Candidal Vulvovaginitis Nos 9
Candidiasis, Vulvovaginal 60
Candidiasis Vulvovaginal 43
 
Monilial Vulvovaginitis 9
Candidal Vulvovaginitis 9
Cervix Disorders 32
Cervix Diseases 60
Cervix Disease 9
Cervix 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


Related Diseases for Vulvovaginal Candidiasis

About this section

Diseases related to Vulvovaginal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.1SKAP2, DEFB4A, CD79A, IFNG
2bacterial vaginosis31.6LAP3, MBL2
3cystic fibrosis30.6DEFB1, LAP3, MBL2, DEFB4A
4deficiency anemia30.1CD79A, IL2, F2
5vulvovaginitis11.4
6vaginitis11.0
7folliculitis10.6DEFB4A
8candida glabrata10.5
9urethritis10.5CD79A
10tonsillitis10.5CD79A
11periodontal disease10.5CD79A
12q fever10.5CD79A
13choledocholithiasis10.5GGT1
14periapical granuloma10.5IL4
15fascioliasis10.4GGT1
16cryptosporidiosis10.4CD79A, MBL2
17acne10.4DEFB4A, DEFB1
18thyroiditis10.4MBL2, CD79A
19immunoglobulin g deficiency10.4CD79A, MBL2
20sinusitis10.4DEFB4A, CD79A
21mesangial proliferative glomerulonephritis10.4CD79A, MBL2
22conjunctivitis10.4NLRP3, CD79A
23immunoglobulin alpha deficiency10.4CD79A, MBL2
24membranoproliferative glomerulonephritis10.4MBL2, CD79A
25neisseria meningitidis infection10.3IL1RN, MBL2
26trichomoniasis10.3
27blindness10.3
28leprosy10.3IL2
29cinca syndrome10.3IL1RN, NLRP3
30bronchiectasis10.3MBL2, CD79A
31allergic bronchopulmonary aspergillosis10.3IL4, MBL2
32gastritis10.3DEFB4A, IL1RN
33otitis media10.3MBL2, DEFB1, CD79A
34oral candidiasis10.3DEFB4A, SKAP2
35selective iga deficiency disease10.3CD79A, IL4
36immunodeficiency, x-linked, with hyper-igm10.3IL4, CD79A
37cholesteatoma10.3DEFB1, DEFB4A
38cork-handlers' disease10.3MBL2, DEFB1, DEFB4A
39duodenal ulcer10.3IL1RN, DEFB1, DEFB4A
40periodontitis10.2DEFB1, IL1RN, DEFB4A
41pulmonary eosinophilia10.2GGT1, IL4
42alcoholic hepatitis10.2F2, GGT1
43bilirubin metabolic disorder10.2F2, GGT1
44portal hypertension10.2F2, GGT1
45alopecia areata10.2IFNG, IL1RN
46pregnancy loss, recurrent 110.2MBL2, F2
47exanthem10.2IL1RN, CD79A, NLRP3
48alcoholic liver cirrhosis10.2F2, GGT1
49relapsing-remitting multiple sclerosis10.2IL1RN, IFNG
50aspergillosis10.2IFNG, CD79A, MBL2

Graphical network of the top 20 diseases related to Vulvovaginal Candidiasis:



Diseases related to vulvovaginal candidiasis

Symptoms for Vulvovaginal Candidiasis

About this section

Drugs & Therapeutics for Vulvovaginal Candidiasis

About this section

Genetic Tests for Vulvovaginal Candidiasis

About this section

Anatomical Context for Vulvovaginal Candidiasis

About this section

MalaCards organs/tissues related to Vulvovaginal Candidiasis:

31
Cervix, Testes, Uterus, Colon, Neutrophil, B cells

Animal Models for Vulvovaginal Candidiasis or affiliated genes

About this section

MGI Mouse Phenotypes related to Vulvovaginal Candidiasis:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7DEFB1, IFNG, IL4, NLRP3, MBL2, CD79A
2MP:00053818.3IL2, IL4, IFNG, F2, NLRP3
3MP:00053908.0GGT1, IL4, F2, IFNG, IL1RN, NLRP3
4MP:00107717.9F2, IFNG, IL4, NLRP3, GGT1, IL1RN
5MP:00053847.9CD79A, NLRP3, IL1RN, IL2, IL4, IFNG
6MP:00053897.6NLRP3, IL1RN, IL2, IL4, F2, GGT1
7MP:00053787.5F2, IL2, IL4, IL1RN, NLRP3, GGT1
8MP:00107687.2F2, DEFB1, IFNG, IL4, IL2, IL1RN
9MP:00053767.1F2, IFNG, IL2, MBL2, IL1RN, GGT1
10MP:00053976.6MBL2, GGT1, SKAP2, NLRP3, CD79A, F2
11MP:00053875.8IL1RN, IL4, MBL2, GGT1, SKAP2, F2

Publications for Vulvovaginal Candidiasis

About this section

Articles related to Vulvovaginal Candidiasis:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Can intrauterine contraceptive devices lead to VulvoVaginal Candidiasis (VVC) andanemia in Iranian new users? (25637424)
2015
2
Comment on "Vulvovaginal Candidiasis as a Chronic Disease: Diagnostic Criteria and Definition" (24769654)
2014
3
Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis. (25143944)
2014
4
Determinants of symptomatic vulvovaginal candidiasis among human immunodeficiency virus type 1 infected women in rural KwaZulu-Natal, South Africa. (24812479)
2014
5
Vulvovaginal candidiasis: species distribution, fluconazole resistance and drug efflux pump gene overexpression. (24962255)
2014
6
Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. (24152852)
2013
7
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
8
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
9
Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis. (23334938)
2013
10
Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis. (23119175)
2012
11
Evaluation of sexual function in Brazilian women with recurrent vulvovaginal candidiasis and localized provoked vulvodynia. (22214370)
2012
12
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
13
Recurrent vulvovaginal candidiasis - current management. (21597520)
2011
14
Antifungal efficacy of propolis against fluconazole-resistant Candida glabrata isolates obtained from women with recurrent vulvovaginal candidiasis. (21669419)
2011
15
Vulvovaginal Candidiasis Caused by Non-albicans Candida Species: New Insights. (21308556)
2010
16
Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. (19187507)
2009
17
Vulvovaginal candidiasis: diagnostic and therapeutic approaches used by Dutch general practitioners. (18464170)
2008
18
Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study. (18612052)
2008
19
Itraconazole vs fluconazole for the treatment of uncomplicated acute vaginal and vulvovaginal candidiasis in nonpregnant women: a metaanalysis of randomized controlled trials. (18068146)
2008
20
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
21
Vulvovaginal candidiasis and its related factors in diabetic women. (18182346)
2007
22
Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis. (17714358)
2007
23
Vulvovaginal candidiasis. (16434042)
2006
24
Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis. (15830422)
2005
25
Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)
2005
26
Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. (15041994)
2004
27
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
28
Prevention and treatment of vulvovaginal candidiasis using exogenous Lactobacillus. (12774870)
2003
29
Vulvovaginal candidiasis. (12228137)
2002
30
Pathogenesis of Recurrent Vulvovaginal Candidiasis. (12433327)
2002
31
Itraconazole (SporanoxAr) for vulvovaginal candidiasis. (12432422)
2002
32
Chronic vulvovaginal candidiasis. (11237084)
2001
33
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). (11687165)
2001
34
Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. (9500475)
1998
35
Treatment of vulvovaginal candidiasis in patients with diabetes. (9540031)
1998
36
Clinical and cost considerations in the pharmacotherapy of vulvovaginal candidiasis. (10160477)
1996
37
Role of antifungal drug resistance in the pathogenesis of recurrent vulvovaginal candidiasis. (8912167)
1996
38
The impact of oral contraception on vulvovaginal candidiasis. (7628203)
1995
39
Treatment options for vulvovaginal candidiasis, 1993. (7795112)
1995
40
Vulvovaginal candidiasis. (7993497)
1994
41
Vulvovaginal candidiasis refractory to treatment with fluconazole. (1587371)
1992
42
Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison. (1941796)
1991
43
Papers selected from presentations given at the symposium "Vulvovaginal Candidiasis: Current Views". January 10-11, 1987. (3364510)
1988
44
Three-day treatment of vulvovaginal candidiasis. (3364485)
1988
45
Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. (3522761)
1986
46
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
47
Vulvovaginal candidiasis treated with clotrimazole cream in seven days compared with fourteen-day treatment with miconazole cream. (360842)
1978
48
Cure rates of oral contraceptive users and non-users when treated for vulvovaginal candidiasis (moniliasis) with miconazole nitrate 2% vaginal cream. (880814)
1977
49
Gynodaktarin (miconazole nitrate) for vulvovaginal candidiasis. (1067505)
1976
50
Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. (4604245)
1974

Variations for Vulvovaginal Candidiasis

About this section

Expression for genes affiliated with Vulvovaginal Candidiasis

About this section
Search GEO for disease gene expression data for Vulvovaginal Candidiasis.

Pathways for genes affiliated with Vulvovaginal Candidiasis

About this section

Pathways related to Vulvovaginal Candidiasis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL2, IFNG
29.6IFNG, IL2
39.6IL2, IFNG
4
Show member pathways
9.4DEFB1, DEFA5, DEFB4A
59.4CD79A, IL2, IL4
6
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4IFNG, DEFB4A, IL4
7
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.3IL4, IFNG, IL1RN
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.3F2, IFNG, IL2
99.2IL2, IL4, IFNG
10
Show member pathways
Immune response CD16 signaling in NK cells58
9.2IL2, IFNG, IL4
11
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.2IL2, IL4, IFNG
129.2IL2, IL4, IFNG
139.2IFNG, IL2, IL4
14
Show member pathways
9.2IL2, IL4, IFNG
159.2IFNG, IL2, IL4
169.2IL4, IL2, IFNG
17
Show member pathways
9.2IL4, IL2, IFNG
18
Show member pathways
Type III interferon signaling36
9.2IL4, IL2, IFNG
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.2IL4, IFNG, IL2
209.2IL4, IFNG, IL2
21
Show member pathways
9.0IL2, IL4, IFNG, NLRP3
22
Show member pathways
8.9IFNG, IL2, CD79A, IL4
23
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.9IFNG, IL2, IL4, CD79A
24
Show member pathways
8.9IL2, IL4, IFNG, F2
25
Show member pathways
8.9IFNG, IL2, IL4, F2
26
Show member pathways
thioredoxin pathway36
8.9GGT1, IFNG, F2

Compounds for genes affiliated with Vulvovaginal Candidiasis

About this section

Compounds related to Vulvovaginal Candidiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1tuberculin439.8CD79A, MBL2, IFNG
2hbd2439.8DEFA5, DEFB4A, DEFB1
3clarithromycin43 1210.8F2, CD79A, IL1RN
4tdac439.8IL4, IL2
5bucillamine439.7IFNG, IL2, CD79A
6adalimumab43 49 1211.7IFNG, IL1RN, CD79A
7interferon gamma439.6IFNG, IL2, IL4
8gold sodium thiomalate439.6IL1RN, IL2, IFNG
9amphotericin b439.6IL1RN, IL4, IFNG
10alpha-galactosylceramide439.6IFNG, IL2, IL4
11glatiramer acetate43 1210.6IFNG, IL4, IL2
12lipoteichoic acid439.5DEFB4A, MBL2, IL1RN
13il-12439.5IL2, IFNG, IL4
14mannose439.5MBL2, IL1RN, DEFB4A, CD79A
15polyethylene glycol439.5CD79A, F2, IL4, IL1RN
16chloroquine43 2 49 28 1213.4IL1RN, CD79A, IL4, IL2
17ivig439.4IL4, IFNG, CD79A, IL1RN
18allergens439.4IL4, CD79A, IFNG, IL1RN
19okt3439.4IL4, IL2, IFNG, CD79A
20il 10439.3IL4, IL1RN, IFNG, IL2
21praziquantel43 1210.3IL4, GGT1, CD79A
22polymyxin b439.3IL1RN, IL4, IFNG, DEFB1, MBL2
23gamma globulin439.3CD79A, GGT1, IFNG
24gm-csf43 2810.2IL4, IL2, IFNG
25simvastatin43 49 59 28 24 1214.2IL4, IFNG, F2, IL1RN
26hydrocortisone43 2 59 1212.2IL2, IFNG, IL4, IL1RN
27prednisolone43 28 1211.2IL2, IL1RN, CD79A, MBL2, IFNG
28con a439.1MBL2, CD79A, IFNG, IL4, IL2
29anti-fungal439.1DEFB4A, CD79A, MBL2, SKAP2, IFNG
30thyroxine43 2410.0CD79A, MBL2, GGT1, IL4
31mycophenolate mofetil43 49 1210.9CD79A, GGT1, IL2, IFNG
32hyaluronic acid43 249.9IL1RN, F2, GGT1, CD79A
33azathioprine43 2 49 1211.9IL4, CD79A, IL2, GGT1
34neopterin438.8CD79A, IFNG, IL4, IL2, IL1RN, MBL2
35pge2438.8CD79A, IL1RN, IL2, IL4, IFNG
36methotrexate49 43 1210.8CD79A, GGT1, NLRP3, IL1RN, F2
37histamine43 28 2410.8IL4, IL1RN, IL2, DEFB4A, CD79A, IFNG
38cyclosporin a43 28 5910.7IFNG, F2, IL4, CD79A, IL1RN, IL2
39ribavirin43 49 1210.6MBL2, GGT1, IL2, IL4, IFNG
40rantes438.6MBL2, IL1RN, IL2, IL4, IFNG, DEFB1
41pentoxifylline43 129.5IFNG, GGT1, IL4, IL2, IL1RN
42tacrolimus43 49 1210.5IL2, GGT1, CD79A, IFNG, IL4
43retinoic acid43 249.3IFNG, LAP3, DEFB4A, DEFB1, CD79A, IL1RN
44indomethacin43 28 59 1211.2IFNG, IL4, IL2, IL1RN, GGT1, CD79A
45creatinine438.2CD79A, MBL2, GGT1, IL1RN, LAP3, F2
46lactate438.2GGT1, IL1RN, LAP3, F2, CD79A
47vegf438.2CD79A, IL1RN, LAP3, IFNG, IL4, IL2
48aspartate437.6GGT1, SKAP2, LAP3, F2, MBL2
49cysteine437.5GGT1, CD79A, MBL2, IL1RN, IL4, LAP3
50dexamethasone43 49 28 1210.5IFNG, IL4, CD79A, MBL2, GGT1, IL1RN

GO Terms for genes affiliated with Vulvovaginal Candidiasis

About this section

Cellular components related to Vulvovaginal Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3CD79A, IL4, IFNG
2Golgi lumenGO:00057969.0DEFB1, DEFA5, DEFB4A, F2
3extracellular spaceGO:00056157.8IL4, IL2, IL1RN, MBL2, DEFA5, F2
4extracellular regionGO:00055767.7MBL2, IL2, IFNG, DEFB1, DEFA5, DEFB4A

Biological processes related to Vulvovaginal Candidiasis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:000267410.1IL4, NLRP3
2negative regulation of growth of symbiont in hostGO:004413010.0MBL2, IFNG
3positive regulation of MHC class II biosynthetic processGO:00453489.9IFNG, IL4
4positive regulation of chemokine biosynthetic processGO:00450809.9IL4, IFNG
5acute-phase responseGO:00069539.8MBL2, IL1RN, F2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8IL4, IL2
7positive regulation of interleukin-1 beta secretionGO:00507189.8NLRP3, IFNG
8defense response to protozoanGO:00428329.8IFNG, IL4
9chemotaxisGO:00069359.8DEFB4A, DEFB1, IL4
10positive regulation of activated T cell proliferationGO:00421049.7IL2, IL4
11extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7IL2, IL4
12defense response to bacteriumGO:00427429.6MBL2, IFNG, DEFB1, DEFB4A
13B cell activationGO:00421139.6SKAP2, CD79A
14positive regulation of isotype switching to IgG isotypesGO:00483049.5IL2, IL4, IFNG
15positive regulation of B cell proliferationGO:00308909.4IL2, IL4
16innate immune responseGO:00450879.2DEFB4A, DEFA5, DEFB1, NLRP3, MBL2
17immune responseGO:00069559.1DEFB4A, DEFB1, IL4, IL2, IL1RN

Molecular functions related to Vulvovaginal Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.2IL2, IL4, IFNG
2growth factor activityGO:00080839.0IL2, IL4, F2

Products for genes affiliated with Vulvovaginal Candidiasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Vulvovaginal Candidiasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet