MCID: VLV011
MIFTS: 67

Vulvovaginal Candidiasis malady

Infectious diseases, Reproductive diseases categories
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Summaries for Vulvovaginal Candidiasis

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MedlinePlus:33 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. the cervix has a small opening that expands during childbirth. it also allows menstrual blood to leave a woman's body. your health care provider may perform a pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. other problems with the cervix include: cervicitis - inflammation of the cervix. this is usually from an infection. cervical incompetence - this can happen during pregnancy. the opening of the cervix widens long before the baby is due. cervical polyps and cysts - abnormal growths on the cervix

MalaCards based summary: Vulvovaginal Candidiasis, also known as cervix disorders, is related to candidiasis and bacterial vaginosis. An important gene associated with Vulvovaginal Candidiasis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Immune response MIF mediated glucocorticoid regulation. The drugs clotrimazole and fluconazole and the compounds tuberculin and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:8 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by candida albicans. the symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

CDC:3 Genital / vulvovaginal candidiasis (VVC) is also sometimes called a "yeast infection," and it occurs when there is overgrowth of the normal yeast in the vagina. This infection is relatively common -- nearly 75% of all adult women have had at least one "yeast infection" in their lifetime.

Wikipedia:65 Candidal vulvovaginitis or vaginal thrush is an infection of the vagina?s mucous membranes by Candida... more...

Aliases & Classifications for Vulvovaginal Candidiasis

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Vulvovaginal Candidiasis, Aliases & Descriptions:

Name: Vulvovaginal Candidiasis 8 10
Cervix Disorders 33 62
Candidiasis of Vulva and Vagina 8
Candidal: Vulvovaginitis Nos 8
Candidal Vulvovaginitis Nos 8
Candidiasis, Vulvovaginal 62
 
Candidiasis Vulvovaginal 44
Candidal Vulvovaginitis 8
Monilial Vulvovaginitis 8
Cervix Diseases 62
Cervix Disease 8
Cervix 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


Related Diseases for Vulvovaginal Candidiasis

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Diseases related to Vulvovaginal Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.0SKAP2, DEFB4A, CD79A, IFNG
2bacterial vaginosis31.5LAP3, MBL2
3cystic fibrosis30.6DEFB1, LAP3, MBL2, DEFB4A
4type 1 diabetes mellitus30.3IL4, IL1RN, IFNG
5deficiency anemia30.1CD79A, IL2, F2
6vulvovaginitis11.4
7vaginitis11.0
8folliculitis10.6DEFB4A
9urethritis10.5CD79A
10tonsillitis10.5CD79A
11periodontal disease10.5CD79A
12q fever10.5CD79A
13candida glabrata10.5
14choledocholithiasis10.5GGT1
15periapical granuloma10.5IL4
16fascioliasis10.4GGT1
17malaria10.4IFNG
18cryptosporidiosis10.4CD79A, MBL2
19thyroiditis10.4MBL2, CD79A
20immunoglobulin g deficiency10.4CD79A, MBL2
21sinusitis10.4DEFB4A, CD79A
22mesangial proliferative glomerulonephritis10.4CD79A, MBL2
23conjunctivitis10.4NLRP3, CD79A
24immunoglobulin alpha deficiency10.4CD79A, MBL2
25membranoproliferative glomerulonephritis10.4MBL2, CD79A
26neisseria meningitidis infection10.3IL1RN, MBL2
27leprosy10.3IL2
28diabetes mellitus10.3
29blindness10.3
30chronic infantile neurological cutaneous articular syndrome10.3IL1RN, NLRP3
31allergic bronchopulmonary aspergillosis10.3IL4, MBL2
32bronchiectasis10.3MBL2, CD79A
33gastritis10.3DEFB4A, IL1RN
34otitis media10.3MBL2, DEFB1, CD79A
35oral candidiasis10.3DEFB4A, SKAP2
36selective iga deficiency disease10.3CD79A, IL4
37cholesteatoma10.3DEFB1, DEFB4A
38immunodeficiency with hyper igm type 110.3IL4, CD79A
39cork-handlers' disease10.3MBL2, DEFB1, DEFB4A
40duodenal ulcer10.3IL1RN, DEFB1, DEFB4A
41periodontitis10.3DEFB1, IL1RN, DEFB4A
42pulmonary eosinophilia10.2GGT1, IL4
43alcoholic hepatitis10.2F2, GGT1
44bilirubin metabolic disorder10.2F2, GGT1
45portal hypertension10.2F2, GGT1
46alopecia areata10.2IFNG, IL1RN
47exanthem10.2IL1RN, CD79A, NLRP3
48aspergillosis10.2IFNG, CD79A, MBL2
49alcoholic liver cirrhosis10.2F2, GGT1
50relapsing-remitting multiple sclerosis10.2IL1RN, IFNG

Graphical network of the top 20 diseases related to Vulvovaginal Candidiasis:



Diseases related to vulvovaginal candidiasis

Symptoms for Vulvovaginal Candidiasis

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Drugs & Therapeutics for Vulvovaginal Candidiasis

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Genetic Tests for Vulvovaginal Candidiasis

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Anatomical Context for Vulvovaginal Candidiasis

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MalaCards organs/tissues related to Vulvovaginal Candidiasis:

32
Cervix, Testes, Uterus, Colon, B cells, Neutrophil

Animal Models for Vulvovaginal Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Vulvovaginal Candidiasis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7DEFB1, IFNG, IL4, NLRP3, MBL2, CD79A
2MP:00053818.3F2, IFNG, IL4, IL2, NLRP3
3MP:00053908.0F2, IFNG, IL4, IL1RN, NLRP3, GGT1
4MP:00107717.9F2, IFNG, IL4, IL1RN, NLRP3, GGT1
5MP:00053847.9F2, IFNG, IL4, IL2, IL1RN, NLRP3
6MP:00053897.6F2, IFNG, IL4, IL2, IL1RN, NLRP3
7MP:00053787.5GGT1, NLRP3, IL1RN, IL2, IL4, IFNG
8MP:00107687.2F2, DEFB1, IFNG, IL4, IL2, IL1RN
9MP:00053767.1F2, IFNG, IL4, IL2, IL1RN, NLRP3
10MP:00053976.6IL2, IL4, IFNG, F2, IL1RN, NLRP3
11MP:00053875.8CD79A, F2, DEFB1, LAP3, IFNG, IL4

Publications for Vulvovaginal Candidiasis

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Articles related to Vulvovaginal Candidiasis:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Comment on "Vulvovaginal Candidiasis as a Chronic Disease: Diagnostic Criteria and Definition" (24769654)
2014
2
Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis. (25143944)
2014
3
Determinants of symptomatic vulvovaginal candidiasis among human immunodeficiency virus type 1 infected women in rural KwaZulu-Natal, South Africa. (24812479)
2014
4
Vulvovaginal candidiasis: species distribution, fluconazole resistance and drug efflux pump gene overexpression. (24962255)
2014
5
Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. (24152852)
2013
6
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
7
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
8
Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis. (23334938)
2013
9
Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis. (23119175)
2012
10
Evaluation of sexual function in Brazilian women with recurrent vulvovaginal candidiasis and localized provoked vulvodynia. (22214370)
2012
11
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
12
Recurrent vulvovaginal candidiasis - current management. (21597520)
2011
13
Antifungal efficacy of propolis against fluconazole-resistant Candida glabrata isolates obtained from women with recurrent vulvovaginal candidiasis. (21669419)
2011
14
Vulvovaginal Candidiasis Caused by Non-albicans Candida Species: New Insights. (21308556)
2010
15
Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. (19187507)
2009
16
Vulvovaginal candidiasis: diagnostic and therapeutic approaches used by Dutch general practitioners. (18464170)
2008
17
Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study. (18612052)
2008
18
Itraconazole vs fluconazole for the treatment of uncomplicated acute vaginal and vulvovaginal candidiasis in nonpregnant women: a metaanalysis of randomized controlled trials. (18068146)
2008
19
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
20
Vulvovaginal candidiasis and its related factors in diabetic women. (18182346)
2007
21
Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis. (17714358)
2007
22
Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis. (17259500)
2007
23
Vulvovaginal candidiasis. (16434042)
2006
24
Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis. (15830422)
2005
25
Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)
2005
26
Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. (15041994)
2004
27
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
28
Prevention and treatment of vulvovaginal candidiasis using exogenous Lactobacillus. (12774870)
2003
29
Vulvovaginal candidiasis. (12228137)
2002
30
Pathogenesis of Recurrent Vulvovaginal Candidiasis. (12433327)
2002
31
Itraconazole (SporanoxAr) for vulvovaginal candidiasis. (12432422)
2002
32
Chronic vulvovaginal candidiasis. (11237084)
2001
33
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). (11687165)
2001
34
Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. (9500475)
1998
35
Treatment of vulvovaginal candidiasis in patients with diabetes. (9540031)
1998
36
Clinical and cost considerations in the pharmacotherapy of vulvovaginal candidiasis. (10160477)
1996
37
Role of antifungal drug resistance in the pathogenesis of recurrent vulvovaginal candidiasis. (8912167)
1996
38
The impact of oral contraception on vulvovaginal candidiasis. (7628203)
1995
39
Treatment options for vulvovaginal candidiasis, 1993. (7795112)
1995
40
Vulvovaginal candidiasis. (7993497)
1994
41
Vulvovaginal candidiasis refractory to treatment with fluconazole. (1587371)
1992
42
Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison. (1941796)
1991
43
Papers selected from presentations given at the symposium "Vulvovaginal Candidiasis: Current Views". January 10-11, 1987. (3364510)
1988
44
Three-day treatment of vulvovaginal candidiasis. (3364485)
1988
45
Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. (3522761)
1986
46
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
47
Vulvovaginal candidiasis treated with clotrimazole cream in seven days compared with fourteen-day treatment with miconazole cream. (360842)
1978
48
Cure rates of oral contraceptive users and non-users when treated for vulvovaginal candidiasis (moniliasis) with miconazole nitrate 2% vaginal cream. (880814)
1977
49
Gynodaktarin (miconazole nitrate) for vulvovaginal candidiasis. (1067505)
1976
50
Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. (4604245)
1974

Variations for Vulvovaginal Candidiasis

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Expression for genes affiliated with Vulvovaginal Candidiasis

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Expression patterns in normal tissues for genes affiliated with Vulvovaginal Candidiasis

Search GEO for disease gene expression data for Vulvovaginal Candidiasis.

Pathways for genes affiliated with Vulvovaginal Candidiasis

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Pathways related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL2, IFNG
29.6IFNG, IL2
39.6IFNG, IL2
4
Show member pathways
9.4DEFB4A, DEFA5, DEFB1
59.4CD79A, IL2, IL4
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4DEFB4A, IFNG, IL4
7
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.3IL1RN, IL4, IFNG
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3IL2, IFNG, F2
9
Show member pathways
Immune response CD16 signaling in NK cells60
9.2IL2, IL4, IFNG
10
Show member pathways
9.2IL2, IL4, IFNG
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.2IL2, IL4, IFNG
129.2IFNG, IL4, IL2
139.2IL2, IL4, IFNG
14
Show member pathways
9.2IL2, IL4, IFNG
159.2IFNG, IL4, IL2
16
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.2IL2, IL4, IFNG
17
Show member pathways
Type III interferon signaling37
9.2IFNG, IL4, IL2
189.2IFNG, IL4, IL2
199.2IL2, IL4, IFNG
209.2IFNG, IL4, IL2
21
Show member pathways
9.0NLRP3, IL2, IL4, IFNG
22
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9CD79A, IL2, IL4, IFNG
23
Show member pathways
8.9CD79A, IL2, IL4, IFNG
24
Show member pathways
8.9IL2, IL4, IFNG, F2
25
Show member pathways
8.9F2, IFNG, IL4, IL2
26
Show member pathways
thioredoxin pathway37
8.9GGT1, IFNG, F2

Compounds for genes affiliated with Vulvovaginal Candidiasis

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Compounds related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1tuberculin449.8CD79A, MBL2, IFNG
2hbd2449.8DEFA5, DEFB4A, DEFB1
3clarithromycin44 1110.8F2, CD79A, IL1RN
4tdac449.8IL4, IL2
5bucillamine449.7IFNG, IL2, CD79A
6adalimumab44 50 1111.7IFNG, IL1RN, CD79A
7interferon gamma449.6IFNG, IL2, IL4
8gold sodium thiomalate449.6IL1RN, IL2, IFNG
9amphotericin b449.6IL1RN, IL4, IFNG
10alpha-galactosylceramide449.6IFNG, IL2, IL4
11glatiramer acetate44 1110.6IFNG, IL4, IL2
12lipoteichoic acid449.5DEFB4A, MBL2, IL1RN
13il-12449.5IL2, IFNG, IL4
14mannose449.5MBL2, IL1RN, DEFB4A, CD79A
15polyethylene glycol449.5CD79A, F2, IL4, IL1RN
16chloroquine44 2 50 28 1113.4IL1RN, CD79A, IL4, IL2
17ivig449.4IL4, IFNG, CD79A, IL1RN
18allergens449.4IL4, CD79A, IFNG, IL1RN
19okt3449.4IL4, IL2, IFNG, CD79A
20il 10449.3IL4, IL1RN, IFNG, IL2
21praziquantel44 1110.3IL4, GGT1, CD79A
22polymyxin b449.3IL1RN, IL4, IFNG, DEFB1, MBL2
23gamma globulin449.3CD79A, GGT1, IFNG
24gm-csf44 2810.2IL4, IL2, IFNG
25simvastatin44 50 61 28 24 1114.2IL4, IFNG, F2, IL1RN
26hydrocortisone44 2 61 1112.2IL2, IFNG, IL4, IL1RN
27prednisolone44 28 1111.2IL2, IL1RN, CD79A, MBL2, IFNG
28con a449.1MBL2, CD79A, IFNG, IL4, IL2
29anti-fungal449.1DEFB4A, CD79A, MBL2, SKAP2, IFNG
30thyroxine44 2410.0CD79A, MBL2, GGT1, IL4
31mycophenolate mofetil44 50 1110.9CD79A, GGT1, IL2, IFNG
32hyaluronic acid44 249.9IL1RN, F2, GGT1, CD79A
33azathioprine44 2 50 1111.9IL4, CD79A, IL2, GGT1
34neopterin448.8CD79A, IFNG, IL4, IL2, IL1RN, MBL2
35pge2448.8CD79A, IL1RN, IL2, IL4, IFNG
36methotrexate50 44 1110.8CD79A, GGT1, NLRP3, IL1RN, F2
37histamine44 28 2410.8IL4, IL1RN, IL2, DEFB4A, CD79A, IFNG
38cyclosporin a44 28 6110.7IFNG, F2, IL4, CD79A, IL1RN, IL2
39ribavirin44 50 1110.6MBL2, GGT1, IL2, IL4, IFNG
40rantes448.6MBL2, IL1RN, IL2, IL4, IFNG, DEFB1
41pentoxifylline44 119.5IFNG, GGT1, IL4, IL2, IL1RN
42tacrolimus44 50 1110.5IL2, GGT1, CD79A, IFNG, IL4
43retinoic acid44 249.3IFNG, LAP3, DEFB4A, DEFB1, CD79A, IL1RN
44indomethacin44 28 61 1111.2IFNG, IL4, IL2, IL1RN, GGT1, CD79A
45creatinine448.2CD79A, MBL2, GGT1, IL1RN, LAP3, F2
46lactate448.2GGT1, IL1RN, LAP3, F2, CD79A
47vegf448.2CD79A, IL1RN, LAP3, IFNG, IL4, IL2
48aspartate447.6GGT1, SKAP2, LAP3, F2, MBL2
49cysteine447.5GGT1, CD79A, MBL2, IL1RN, IL4, LAP3
50dexamethasone44 50 28 1110.5IFNG, IL4, CD79A, MBL2, GGT1, IL1RN

GO Terms for genes affiliated with Vulvovaginal Candidiasis

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Cellular components related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD79A, IL4, IFNG
2Golgi lumenGO:0057969.0F2, DEFB4A, DEFA5, DEFB1
3extracellular spaceGO:0056157.8MBL2, IL1RN, IL2, IL4, IFNG, DEFA5
4extracellular regionGO:0055767.7F2, DEFB4A, DEFA5, DEFB1, IFNG, IL2

Biological processes related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.1IL4, NLRP3
2negative regulation of growth of symbiont in hostGO:04413010.0MBL2, IFNG
3positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
4positive regulation of chemokine biosynthetic processGO:0450809.9IL4, IFNG
5acute-phase responseGO:0069539.8MBL2, IL1RN, F2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IL4, IL2
7positive regulation of interleukin-1 beta secretionGO:0507189.8NLRP3, IFNG
8defense response to protozoanGO:0428329.8IFNG, IL4
9chemotaxisGO:0069359.8DEFB4A, DEFB1, IL4
10positive regulation of activated T cell proliferationGO:0421049.7IL2, IL4
11extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IL2, IL4
12defense response to bacteriumGO:0427429.6MBL2, IFNG, DEFB1, DEFB4A
13B cell activationGO:0421139.6SKAP2, CD79A
14positive regulation of isotype switching to IgG isotypesGO:0483049.5IL2, IL4, IFNG
15positive regulation of B cell proliferationGO:0308909.4IL2, IL4
16innate immune responseGO:0450879.2DEFB4A, DEFA5, DEFB1, NLRP3, MBL2
17immune responseGO:0069559.1DEFB4A, DEFB1, IL4, IL2, IL1RN

Molecular functions related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2IL2, IL4, IFNG
2growth factor activityGO:0080839.0IL2, IL4, F2

Products for genes affiliated with Vulvovaginal Candidiasis

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Sources for Vulvovaginal Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet