MCID: VLV011
MIFTS: 66

Vulvovaginal Candidiasis malady

Infectious diseases, Reproductive diseases categories

Summaries for Vulvovaginal Candidiasis

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9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. the cervix has a small opening that expands during childbirth. it also allows menstrual blood to leave a woman's body. your health care provider may perform a pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. other problems with the cervix include: cervicitis - inflammation of the cervix. this is usually from an infection. cervical incompetence - this can happen during pregnancy. the opening of the cervix widens long before the baby is due. cervical polyps and cysts - abnormal growths on the cervix

MalaCards: Vulvovaginal Candidiasis, also known as candidiasis of vulva and vagina, is related to candidiasis and bacterial vaginosis. An important gene associated with Vulvovaginal Candidiasis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The drugs ketoconazole and miconazole and the compounds tuberculin and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:9 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by candida albicans. the symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

CDC:4 Genital / vulvovaginal candidiasis (VVC) is also sometimes called a "yeast infection," and it occurs when there is overgrowth of the normal yeast in the vagina. This infection is relatively common -- nearly 75% of all adult women have had at least one "yeast infection" in their lifetime.

Wikipedia:66 Candidal vulvovaginitis or vaginal thrush is an infection of the vagina?s mucous membranes by Candida... more...

Aliases & Classifications for Vulvovaginal Candidiasis

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

vulvovaginal candidiasis 9 11
candidiasis of vulva and vagina 9
candidal: vulvovaginitis nos 9
candidal vulvovaginitis nos 9
candidiasis, vulvovaginal 63
candidiasis vulvovaginal 46
candidal vulvovaginitis 9
monilial vulvovaginitis 9
cervix disorders 35
cervix diseases 63
cervix disease 9
cervix 9


Related Diseases for Vulvovaginal Candidiasis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Vulvovaginal Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.1SKAP2, DEFB4A, CD79A, IFNG
2bacterial vaginosis31.1LAP3, MBL2
3cystic fibrosis30.3DEFB1, LAP3, MBL2, DEFB4A
4type 1 diabetes mellitus30.3IL4, IL1RN, IFNG
5deficiency anemia30.2CD79A, IL2, F2
6vulvovaginitis11.4
7vaginitis11.0
8candida glabrata10.4
9diabetes mellitus10.3
10blindness10.3
11trichomoniasis10.2
12iron deficiency anemia10.2
13lichen sclerosus10.2
14vulvar vestibulitis syndrome10.2
15folliculitis10.1DEFB4A
16urethritis10.1CD79A
17tonsillitis10.1CD79A
18periodontal disease10.1CD79A
19q fever10.1CD79A
20choledocholithiasis10.1GGT1
21periapical granuloma10.1IL4
22fascioliasis10.1GGT1
23malaria10.1IFNG
24cryptosporidiosis10.1CD79A, MBL2
25thyroiditis10.1MBL2, CD79A
26immunoglobulin g deficiency10.1CD79A, MBL2
27sinusitis10.1DEFB4A, CD79A
28mesangial proliferative glomerulonephritis10.1CD79A, MBL2
29conjunctivitis10.1NLRP3, CD79A
30immunoglobulin alpha deficiency10.1CD79A, MBL2
31membranoproliferative glomerulonephritis10.1MBL2, CD79A
32neisseria meningitidis infection10.1IL1RN, MBL2
33leprosy10.1IL2
34chronic infantile neurological cutaneous articular syndrome10.1IL1RN, NLRP3
35allergic bronchopulmonary aspergillosis10.1IL4, MBL2
36bronchiectasis10.1MBL2, CD79A
37gastritis10.1DEFB4A, IL1RN
38otitis media10.1MBL2, DEFB1, CD79A
39oral candidiasis10.1DEFB4A, SKAP2
40selective iga deficiency disease10.1CD79A, IL4
41cholesteatoma10.1DEFB1, DEFB4A
42immunodeficiency with hyper igm type 110.1IL4, CD79A
43cork-handlers' disease10.1MBL2, DEFB1, DEFB4A
44duodenal ulcer10.1IL1RN, DEFB1, DEFB4A
45periodontitis10.1DEFB1, IL1RN, DEFB4A
46pulmonary eosinophilia10.1GGT1, IL4
47alcoholic hepatitis10.1F2, GGT1
48bilirubin metabolic disorder10.1F2, GGT1
49portal hypertension10.1F2, GGT1
50alopecia areata10.1IFNG, IL1RN

Graphical network of the top 20 diseases related to Vulvovaginal Candidiasis:



Diseases related to vulvovaginal candidiasis

Symptoms for Vulvovaginal Candidiasis

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Drugs & Therapeutics for Vulvovaginal Candidiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Vulvovaginal Candidiasis

Drug clinical trials:

Search ClinicalTrials for Vulvovaginal Candidiasis

Search NIH Clinical Center for Vulvovaginal Candidiasis

Search CenterWatch for Vulvovaginal Candidiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Vulvovaginal Candidiasis

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Anatomical Context for Vulvovaginal Candidiasis

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34MalaCards
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MalaCards organs/tissues related to Vulvovaginal Candidiasis:

34
Cervix, Testes, Uterus, Colon, B cells

Animal Models for Vulvovaginal Candidiasis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Vulvovaginal Candidiasis:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7DEFB1, IFNG, IL4, NLRP3, MBL2, CD79A
2MP:00053818.3IL2, IL4, IFNG, F2, NLRP3
3MP:00053908.0GGT1, IL4, F2, IFNG, IL1RN, NLRP3
4MP:00107717.9F2, IFNG, IL4, NLRP3, GGT1, IL1RN
5MP:00053847.9CD79A, NLRP3, IL1RN, IL2, IL4, IFNG
6MP:00053897.6NLRP3, IL1RN, IL2, IL4, F2, GGT1
7MP:00053787.5F2, IL2, IL4, IL1RN, NLRP3, GGT1
8MP:00107687.2F2, DEFB1, IFNG, IL4, IL2, IL1RN
9MP:00053767.1F2, IFNG, IL2, MBL2, IL1RN, GGT1
10MP:00053976.6MBL2, GGT1, SKAP2, NLRP3, CD79A, F2
11MP:00053875.8IL1RN, IL4, MBL2, GGT1, SKAP2, F2

Publications for Vulvovaginal Candidiasis

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53PubMed
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Articles related to Vulvovaginal Candidiasis:

(show top 50)    (show all 301)
idTitleAuthorsYear
1
Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. (24152852)
2013
2
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
3
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
4
Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis. (23334938)
2013
5
Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis. (23119175)
2012
6
Evaluation of sexual function in Brazilian women with recurrent vulvovaginal candidiasis and localized provoked vulvodynia. (22214370)
2012
7
Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis. (21655939)
2012
8
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
9
Recurrent vulvovaginal candidiasis - current management. (21597520)
2011
10
Antifungal efficacy of propolis against fluconazole-resistant Candida glabrata isolates obtained from women with recurrent vulvovaginal candidiasis. (21669419)
2011
11
The recurrent vulvovaginal candidiasis: proposal of a personalized therapeutic protocol. (21845227)
2011
12
Vulvovaginal Candidiasis Caused by Non-albicans Candida Species: New Insights. (21308556)
2010
13
Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. (19187507)
2009
14
Vulvovaginal candidiasis: diagnostic and therapeutic approaches used by Dutch general practitioners. (18464170)
2008
15
Itraconazole vs fluconazole for the treatment of uncomplicated acute vaginal and vulvovaginal candidiasis in nonpregnant women: a metaanalysis of randomized controlled trials. (18068146)
2008
16
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
17
Vulvovaginal candidiasis and its related factors in diabetic women. (18182346)
2007
18
Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis. (17714358)
2007
19
Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis. (17259500)
2007
20
Vulvovaginal candidiasis. (16434042)
2006
21
Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis. (15830422)
2005
22
Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)
2005
23
Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. (15041994)
2004
24
Chronic vulvovaginal candidiasis. (15329419)
2004
25
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
26
Prevention and treatment of vulvovaginal candidiasis using exogenous Lactobacillus. (12774870)
2003
27
Vulvovaginal candidiasis. (12228137)
2002
28
Pathogenesis of Recurrent Vulvovaginal Candidiasis. (12433327)
2002
29
Review: oral and intravaginal agents are equally effective for treatment of uncomplicated vulvovaginal candidiasis. (12093214)
2002
30
Chronic vulvovaginal candidiasis. (11237084)
2001
31
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). (11687165)
2001
32
Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. (9500475)
1998
33
Treatment of vulvovaginal candidiasis in patients with diabetes. (9540031)
1998
34
Clinical and cost considerations in the pharmacotherapy of vulvovaginal candidiasis. (10160477)
1996
35
Role of antifungal drug resistance in the pathogenesis of recurrent vulvovaginal candidiasis. (8912167)
1996
36
The impact of oral contraception on vulvovaginal candidiasis. (7628203)
1995
37
Treatment options for vulvovaginal candidiasis, 1993. (7795112)
1995
38
Vaginal microbiological flora and sexually transmitted diseases in women with recurrent or current vulvovaginal candidiasis. (7622268)
1995
39
Vulvovaginal candidiasis. (7993497)
1994
40
Vulvovaginal candidiasis refractory to treatment with fluconazole. (1587371)
1992
41
Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison. (1941796)
1991
42
Papers selected from presentations given at the symposium "Vulvovaginal Candidiasis: Current Views". January 10-11, 1987. (3364510)
1988
43
Three-day treatment of vulvovaginal candidiasis. (3364485)
1988
44
One-day management of vulvovaginal candidiasis. (3694187)
1987
45
Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. (3522761)
1986
46
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
47
Vulvovaginal candidiasis treated with clotrimazole cream in seven days compared with fourteen-day treatment with miconazole cream. (360842)
1978
48
Cure rates of oral contraceptive users and non-users when treated for vulvovaginal candidiasis (moniliasis) with miconazole nitrate 2% vaginal cream. (880814)
1977
49
Gynodaktarin (miconazole nitrate) for vulvovaginal candidiasis. (1067505)
1976
50
Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. (4604245)
1974

Variations for Vulvovaginal Candidiasis

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Expression for genes affiliated with Vulvovaginal Candidiasis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vulvovaginal Candidiasis

Search GEO for disease gene expression data for Vulvovaginal Candidiasis.

Pathways for genes affiliated with Vulvovaginal Candidiasis

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Sources:
51PathCards, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 5Cell Signaling Technology, 54QIAGEN, 31KEGG
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Pathways related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL2, IFNG
29.6IFNG, IL2
39.6IL2, IFNG
4
Show member pathways
9.4DEFB1, DEFA5, DEFB4A
59.4CD79A, IL2, IL4
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4IFNG, DEFB4A, IL4
7
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.3IL4, IFNG, IL1RN
8
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.3F2, IFNG, IL2
99.2IL2, IL4, IFNG
10
Show member pathways
Immune response CD16 signaling in NK cells61
9.2IL2, IFNG, IL4
11
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.2IL2, IL4, IFNG
129.2IL2, IL4, IFNG
139.2IFNG, IL2, IL4
14
Show member pathways
9.2IL2, IL4, IFNG
159.2IFNG, IL2, IL4
169.2IL4, IL2, IFNG
17
Show member pathways
9.2IL4, IL2, IFNG
18
Show member pathways
Type III interferon signaling39
9.2IL4, IL2, IFNG
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.2IL4, IFNG, IL2
209.2IL4, IFNG, IL2
21
Show member pathways
9.0IL2, IL4, IFNG, NLRP3
22
Show member pathways
8.9IFNG, IL2, CD79A, IL4
23
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9IFNG, IL2, IL4, CD79A
24
Show member pathways
8.9IL2, IL4, IFNG, F2
25
Show member pathways
8.9IFNG, IL2, IL4, F2
26
Show member pathways
thioredoxin pathway39
8.9GGT1, IFNG, F2

Compounds for genes affiliated with Vulvovaginal Candidiasis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1tuberculin469.8CD79A, MBL2, IFNG
2hbd2469.8DEFA5, DEFB4A, DEFB1
3clarithromycin46 1210.8F2, CD79A, IL1RN
4tdac469.8IL4, IL2
5bucillamine469.7IFNG, IL2, CD79A
6adalimumab46 52 1211.7IFNG, IL1RN, CD79A
7interferon gamma469.6IFNG, IL2, IL4
8gold sodium thiomalate469.6IL1RN, IL2, IFNG
9amphotericin b469.6IL1RN, IL4, IFNG
10alpha-galactosylceramide469.6IFNG, IL2, IL4
11glatiramer acetate46 1210.6IFNG, IL4, IL2
12lipoteichoic acid469.5DEFB4A, MBL2, IL1RN
13il-12469.5IL2, IFNG, IL4
14mannose469.5MBL2, IL1RN, DEFB4A, CD79A
15polyethylene glycol469.5CD79A, F2, IL4, IL1RN
16chloroquine46 3 52 30 1213.4IL1RN, CD79A, IL4, IL2
17ivig469.4IL4, IFNG, CD79A, IL1RN
18allergens469.4IL4, CD79A, IFNG, IL1RN
19okt3469.4IL4, IL2, IFNG, CD79A
20il 10469.3IL4, IL1RN, IFNG, IL2
21praziquantel46 1210.3IL4, GGT1, CD79A
22polymyxin b469.3IL1RN, IL4, IFNG, DEFB1, MBL2
23gamma globulin469.3CD79A, GGT1, IFNG
24gm-csf46 3010.2IL4, IL2, IFNG
25simvastatin46 52 62 30 25 1214.2IL4, IFNG, F2, IL1RN
26hydrocortisone46 3 62 1212.2IL2, IFNG, IL4, IL1RN
27prednisolone46 30 1211.2IL2, IL1RN, CD79A, MBL2, IFNG
28con a469.1MBL2, CD79A, IFNG, IL4, IL2
29anti-fungal469.1DEFB4A, CD79A, MBL2, SKAP2, IFNG
30thyroxine46 2510.0CD79A, MBL2, GGT1, IL4
31mycophenolate mofetil46 52 1210.9CD79A, GGT1, IL2, IFNG
32hyaluronic acid46 259.9IL1RN, F2, GGT1, CD79A
33azathioprine46 3 52 1211.9IL4, CD79A, IL2, GGT1
34neopterin468.8CD79A, IFNG, IL4, IL2, IL1RN, MBL2
35pge2468.8CD79A, IL1RN, IL2, IL4, IFNG
36methotrexate52 46 1210.8CD79A, GGT1, NLRP3, IL1RN, F2
37histamine46 30 2510.8IL4, IL1RN, IL2, DEFB4A, CD79A, IFNG
38cyclosporin a46 30 6210.7IFNG, F2, IL4, CD79A, IL1RN, IL2
39ribavirin46 52 1210.6MBL2, GGT1, IL2, IL4, IFNG
40rantes468.6MBL2, IL1RN, IL2, IL4, IFNG, DEFB1
41pentoxifylline46 129.5IFNG, GGT1, IL4, IL2, IL1RN
42tacrolimus46 52 1210.5IL2, GGT1, CD79A, IFNG, IL4
43retinoic acid46 259.3IFNG, LAP3, DEFB4A, DEFB1, CD79A, IL1RN
44indomethacin46 30 62 1211.2IFNG, IL4, IL2, IL1RN, GGT1, CD79A
45creatinine468.2CD79A, MBL2, GGT1, IL1RN, LAP3, F2
46lactate468.2GGT1, IL1RN, LAP3, F2, CD79A
47vegf468.2CD79A, IL1RN, LAP3, IFNG, IL4, IL2
48aspartate467.6GGT1, SKAP2, LAP3, F2, MBL2
49cysteine467.5GGT1, CD79A, MBL2, IL1RN, IL4, LAP3
50dexamethasone46 52 30 1210.5IFNG, IL4, CD79A, MBL2, GGT1, IL1RN

GO Terms for genes affiliated with Vulvovaginal Candidiasis

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Sources:
17Gene Ontology
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Cellular components related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD79A, IL4, IFNG
2Golgi lumenGO:0057969.0DEFB1, DEFA5, DEFB4A, F2
3extracellular spaceGO:0056157.8IL4, IL2, IL1RN, MBL2, DEFA5, F2
4extracellular regionGO:0055767.7MBL2, IL2, IFNG, DEFB1, DEFA5, DEFB4A

Biological processes related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.1IL4, NLRP3
2negative regulation of growth of symbiont in hostGO:04413010.0MBL2, IFNG
3positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
4positive regulation of chemokine biosynthetic processGO:0450809.9IFNG, IL4
5acute-phase responseGO:0069539.8MBL2, IL1RN, F2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IL2, IL4
7positive regulation of interleukin-1 beta secretionGO:0507189.8NLRP3, IFNG
8defense response to protozoanGO:0428329.8IFNG, IL4
9chemotaxisGO:0069359.8IL4, DEFB1, DEFB4A
10positive regulation of activated T cell proliferationGO:0421049.7IL2, IL4
11extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IL2, IL4
12defense response to bacteriumGO:0427429.6MBL2, DEFB4A, DEFB1, IFNG
13B cell activationGO:0421139.6SKAP2, CD79A
14positive regulation of isotype switching to IgG isotypesGO:0483049.5IFNG, IL2, IL4
15positive regulation of B cell proliferationGO:0308909.4IL2, IL4
16innate immune responseGO:0450879.2MBL2, NLRP3, DEFB4A, DEFA5, DEFB1
17immune responseGO:0069559.1DEFB4A, DEFB1, IL4, IL2, IL1RN

Molecular functions related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2IL2, IL4, IFNG
2growth factor activityGO:0080839.0IL2, IL4, F2

Products for genes affiliated with Vulvovaginal Candidiasis

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  • Antibodies
  • Proteins
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Sources for Vulvovaginal Candidiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet