MCID: VLV011
MIFTS: 61

Vulvovaginal Candidiasis malady

Infectious, Reproductive categories

Summaries for Vulvovaginal Candidiasis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. the cervix has a small opening that expands during childbirth. it also allows menstrual blood to leave a woman's body. your health care provider may perform a pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. other problems with the cervix include: cervicitis - inflammation of the cervix. this is usually from an infection. cervical incompetence - this can happen during pregnancy. the opening of the cervix widens long before the baby is due. cervical polyps and cysts - abnormal growths on the cervix

MalaCards: Vulvovaginal Candidiasis, also known as candidiasis of vulva and vagina, is related to adenocarcinoma and oral candidiasis. An important gene associated with Vulvovaginal Candidiasis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Spinal Cord Injury and Beta defensins. The drugs clotrimazole and fluconazole and the compounds prednisolone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and cervix, and related mouse phenotypes are renal/urinary system and reproductive system.

Disease Ontology:8 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by candida albicans. the symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

CDC:3 Genital / vulvovaginal candidiasis (VVC) is also sometimes called a "yeast infection," and it occurs when there is overgrowth of the normal yeast in the vagina. This infection is relatively common -- nearly 75% of all adult women have had at least one "yeast infection" in their lifetime.

Wikipedia:64 Candidal vulvovaginitis or vaginal thrush is an infection of the vagina’s mucous membranes by Candida... more...

Aliases & Classifications for Vulvovaginal Candidiasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Reproductive


Aliases & Descriptions:

vulvovaginal candidiasis 8 10
candidiasis of vulva and vagina 8
candidal: vulvovaginitis nos 8
candidal vulvovaginitis nos 8
candidiasis, vulvovaginal 61
candidiasis vulvovaginal 45
monilial vulvovaginitis 8
candidal vulvovaginitis 8
cervix disorders 34
cervix diseases 61
cervix disease 8
cervix 8


Related Diseases for Vulvovaginal Candidiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vulvovaginal Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 421)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.5LAP3, GGT1
2oral candidiasis31.2DEFB4A, SKAP2
3bacterial vaginosis30.9MBL2, LAP3
4adenoma30.5GGT1
5cystic fibrosis30.2MBL2, DEFB1, DEFB4A, LAP3
6deficiency anemia30.2F2, IL2, CD79A
7arthropathy29.9IL1RN, NLRP3
8tuberculosis29.8IL2, IL4, CD79A, DEFB4A, MBL2, IFNG
9macroglobulinemia29.6CD79A
10colorectal cancer29.6IL2
11acute leukemia29.6IL2
12vaccinia29.6IL2
13vasculitis29.6MBL2, CD79A, F2
14stomach cancer29.6MBL2, DEFB4A, IL1RN
15arthritis29.6NLRP3, IFNG, IL1RN, IL4
16squamous cell carcinoma10.9
17cervix small cell carcinoma10.7
18small cell carcinoma10.7
19clear cell adenocarcinoma10.7
20neuroendocrine carcinoma10.6
21adenosquamous carcinoma10.6
22cervical intraepithelial neoplasia10.6
23adenocarcinoma in situ10.5
24adenosarcoma10.5
25candida glabrata10.5
26cervix squamous papilloma10.4
27verrucous carcinoma10.4
28cervix uteri carcinoma in situ10.4
29uterine sarcoma10.4
30primary malignant lymphoma10.4
31hypoxia10.4
32squamous cell papilloma10.3
33cervix endometriosis10.3
34vulvovaginitis10.3
35cervical incompetence10.3
36mucinous adenocarcinoma10.3
37peutz-jeghers syndrome10.3
38large cell carcinoma10.3
39uterine disease10.3
40peutz–jeghers syndrome10.3
41cervix melanoma10.3
42alveolar soft part sarcoma10.3
43adenoid cystic carcinoma10.3
44adenofibroma10.3
45glassy cell carcinoma of the cervix10.3
46primary malignant melanoma of the cervix10.3
47papillary carcinoma10.2
48granuloma inguinale10.2
49papillary adenofibroma10.2
50botryoid rhabdomyosarcoma10.2

Graphical network of the top 20 diseases related to Vulvovaginal Candidiasis:



Diseases related to vulvovaginal candidiasis

Clinical Features for Vulvovaginal Candidiasis

Drugs & Therapeutics for Vulvovaginal Candidiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vulvovaginal Candidiasis

Drug clinical trials:

Search ClinicalTrials for Vulvovaginal Candidiasis

Search NIH Clinical Center for Vulvovaginal Candidiasis

Search CenterWatch for Vulvovaginal Candidiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Vulvovaginal Candidiasis

Anatomical Context for Vulvovaginal Candidiasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vulvovaginal Candidiasis:

33
Uterus, Colon, Cervix, T cells, B cells

Animal Models for Vulvovaginal Candidiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Vulvovaginal Candidiasis

Sources:
51PubMed
See all sources

Articles related to Vulvovaginal Candidiasis:

(show top 50)    (show all 303)
idTitleAuthorsYear
1
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
2
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
3
Lamisil versus clotrimazole in the treatment of vulvovaginal candidiasis. (23466900)
2013
4
NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response. (24063977)
2013
5
Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis. (21655939)
2012
6
Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product, in women affected by vulvovaginal candidiasis: a pilot study. (22955364)
2012
7
The recurrent vulvovaginal candidiasis: proposal of a personalized therapeutic protocol. (21845227)
2011
8
Molecular typing and in vitro fluconazole susceptibility of Candida species isolated from diabetic and nondiabetic women with vulvovaginal candidiasis in India. (21524609)
2011
9
Vulvovaginal candidiasis in Mato Grosso, Brazil: pregnancy status, causative species and drugs tests. (24031756)
2011
10
Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis. (19646572)
2009
11
Efficient diagnosis of vulvovaginal candidiasis by use of a new rapid immunochromatography test. (19794036)
2009
12
Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study. (18612052)
2008
13
Not that itch again: dealing with recurrent vulvovaginal candidiasis. (18557851)
2008
14
A 5-year (2000-2004) epidemiological survey of Candida and non-Candida yeast species causing vulvovaginal candidiasis in Graz, Austria. (17022763)
2006
15
Glucose in vaginal secretions before and after oral glucose tolerance testing in women with and without recurrent vulvovaginal candidiasis. (17138777)
2006
16
Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)
2005
17
Vulvovaginal candidiasis in a Flemish patient population. (16307555)
2005
18
Safety and efficacy of bedtime versus daytime administration of the miconazole nitrate 1200 mg vaginal ovule insert to treat vulvovaginal candidiasis. (15881484)
2005
19
Current treatment options for vulvovaginal candidiasis. (19803842)
2005
20
Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. (15329425)
2004
21
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
22
Prevention and treatment of vulvovaginal candidiasis using exogenous Lactobacillus. (12774870)
2003
23
An epidemiological survey of vulvovaginal candidiasis in Italy. (12932875)
2003
24
IgA, IgE and IgG subclasses to Candida albicans in serum and vaginal fluid from patients with vulvovaginal candidiasis]. (14963598)
2003
25
Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis. (12151172)
2002
26
Oral versus intra-vaginal imidazole and triazole anti-fungal agents for the treatment of uncomplicated vulvovaginal candidiasis (thrush): a systematic review. (11843377)
2002
27
Drugs for vulvovaginal candidiasis. (11151090)
2001
28
Determinants of incident vulvovaginal candidiasis in human immunodeficiency virus-positive women. (10968602)
2000
29
Treatment options for vulvovaginal candidiasis, 1993. (7795112)
1995
30
Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis. (1877264)
1991
31
Evidence for a role for secreted aspartate proteinase of Candida albicans in vulvovaginal candidiasis. (2189009)
1990
32
The epidemiology of vulvovaginal candidiasis: risk factors. (2305918)
1990
33
A comparison of butoconazole nitrate cream with econazole nitrate cream for the treatment of vulvovaginal candidiasis. (2257961)
1990
34
Terconazole for the treatment of vulvovaginal candidiasis. (2277372)
1990
35
Pathophysiology of vulvovaginal candidiasis. (2677361)
1989
36
Comparison of three-day butoconazole treatment with seven-day miconazole treatment for vulvovaginal candidiasis. (2671362)
1989
37
One-day management of vulvovaginal candidiasis. (3694187)
1987
38
Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. (3522761)
1986
39
Recurrent vulvovaginal candidiasis: vaginal epithelial cell susceptibility to Candida albicans adherence. (3517722)
1986
40
Depo-Provera in the treatment of recurrent vulvovaginal candidiasis. (2945926)
1986
41
Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis. (3895958)
1985
42
A comparison of the efficacy of two vaginal creams for vulvovaginal candidiasis, and correlations with the presence of Candida species in the perianal area and oral contraceptive use. (6347382)
1983
43
A three-day treatment regimen for vulvovaginal candidiasis. (6750015)
1982
44
The boric acid powder treatment of vulvovaginal candidiasis. (7328233)
1981
45
Treatment of vulvovaginal candidiasis with boric acid powder. (7282789)
1981
46
Miconazole in the treatment of vulvovaginal candidiasis: comparison of a 6-day therapy and a 3-day treatment course. (7189485)
1980
47
Gynodaktarin (miconazole nitrate) for vulvovaginal candidiasis. (1067505)
1976
48
Three-day therapy of vulvovaginal candidiasis with econazole: a multicentric study comprising 996 cases. (984105)
1976
49
MONISTAT: a new fungicide for treatment of vulvovaginal candidiasis. (4429114)
1974
50
The clinical use of Taschdjian's medium in the diagnosis of vulvovaginal candidiasis. (13837061)
1960

Genetic Variations for Vulvovaginal Candidiasis

Expression for genes affiliated with Vulvovaginal Candidiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vulvovaginal Candidiasis

Search GEO for disease gene expression data for Vulvovaginal Candidiasis.

Pathways for genes affiliated with Vulvovaginal Candidiasis

Sources:
38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL4, IL2
2
Hide members
9.4DEFB4A, DEFB1, DEFA5
3
Immune response Bacterial infections in normal airways
Hide members
9.4IFNG, DEFB4A, IL1RN
4
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.3IL4, IL1RN, IFNG
5
Development PDGF signaling via STATs and NF-kB
Hide members
9.3F2, IL2, IFNG
69.3IL2, IL4, IFNG
79.3IL2, IL4, IFNG
8
Hide members
9.3IL2, IL4, IFNG
99.3IL2, IL4, IFNG
10
Hide members
9.3IL2, IL4, IFNG
119.3IFNG, IL4, IL2
129.3IFNG, IL4, IL2
13
Hide members
9.0IL2, IL4, IFNG, NLRP3
14
Hide members
9.0IFNG, CD79A, IL4, IL2
15
Hide members
9.0IFNG, CD79A, IL4, IL2
16
Hide members
9.0IFNG, CD79A, IL4, IL2
178.9GGT1, F2, IFNG
18
Hide members
7.4IL2, NLRP3, IFNG, MBL2, DEFA5, DEFB1

Compounds for genes affiliated with Vulvovaginal Candidiasis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1prednisolone45 29 1112.4CD79A, MBL2
2gm-csf45 2911.2IFNG
3indomethacin45 60 29 1113.1GGT1
4pge24510.1IL2
5gamma globulin4510.0GGT1
6tdac4510.0IL4, IL2
7tuberculin459.8IFNG, MBL2, CD79A
8cyclosporin a45 29 6011.8IFNG, CD79A, F2
9hbd2459.8DEFA5, DEFB1, DEFB4A
10clarithromycin45 1110.7CD79A, IL1RN, F2
11bucillamine459.7IFNG, CD79A, IL2
12lipoteichoic acid459.7IL1RN, DEFB4A, MBL2
13interferon gamma459.7IFNG, IL4, IL2
14alpha-galactosylceramide459.7IFNG, IL4, IL2
15adalimumab45 50 1111.6IL1RN, CD79A, IFNG
16glatiramer acetate45 1110.6IFNG, IL4, IL2
17amphotericin b459.6IFNG, IL1RN, IL4
18gold sodium thiomalate459.6IFNG, IL1RN, IL2
19il-12459.5IFNG, IL4, IL2
20polyethylene glycol459.5F2, IL4, IL1RN, CD79A
21mannose459.4MBL2, DEFB4A, CD79A, IL1RN
22okt3459.4IFNG, CD79A, IL4, IL2
23ivig459.4IL4, IL1RN, CD79A, IFNG
24chloroquine45 2 50 29 1113.4IL2, IL4, IL1RN, CD79A
25allergens459.4IFNG, CD79A, IL1RN, IL4
26pentoxifylline45 1110.4IL1RN, IL4, GGT1
27praziquantel45 1110.3CD79A, IL4, GGT1
28il 10459.3IFNG, IL1RN, IL4, IL2
29dexamethasone45 50 29 1112.3DEFB1, DEFB4A, CD79A, GGT1
30polymyxin b459.3IFNG, MBL2, DEFB1, IL1RN, IL4
31simvastatin45 50 60 29 11 2414.2F2, IL4, IL1RN, IFNG
32rantes459.2IL2, IL4, DEFB4A, MBL2, IFNG
33con a459.2IFNG, MBL2, CD79A, IL4, IL2
34anti-fungal459.1IFNG, MBL2, DEFB4A, CD79A, SKAP2
35p-nitroaniline459.1LAP3, GGT1
36thyroxine45 2410.0MBL2, CD79A, IL4, GGT1
37polyinosinic-polycytidylic acid459.0IFNG, IL4, IL2
38calcitriol45 60 11 2411.9F2, IL2, IL4, IFNG
39mycophenolate mofetil45 50 1110.9GGT1, IL2, CD79A, IFNG
40azathioprine45 50 2 1111.9CD79A, IL4, IL2, GGT1
41hyaluronic acid45 249.9CD79A, IL1RN, F2, GGT1
42neopterin458.8IL2, IL4, IL1RN, CD79A, MBL2, IFNG
43methotrexate45 50 1110.8GGT1, F2, IL1RN, CD79A, NLRP3
44histamine45 29 2410.7IFNG, DEFB4A, CD79A, IL1RN, IL4, IL2
45ribavirin45 50 1110.6GGT1, IL2, IL4, MBL2, IFNG
46tacrolimus45 50 1110.5IFNG, CD79A, IL4, IL2, GGT1
47creatinine458.2MBL2, CD79A, IL1RN, F2, GGT1, LAP3
48vegf458.1IFNG, MBL2, CD79A, IL1RN, IL4, IL2
49lactate457.9LAP3, GGT1, F2, IL1RN, CD79A
50cysteine457.5IFNG, MBL2, DEFB4A, CD79A, IL1RN, IL4

GO Terms for genes affiliated with Vulvovaginal Candidiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.8DEFA5, DEFB1, DEFB4A, F2
2extracellular regionGO:0055768.0F2, IL2, DEFB4A, DEFB1, DEFA5, MBL2
3extracellular spaceGO:0056157.7F2, IL2, IL4, IL1RN, DEFA5, MBL2

Biological processes related to Vulvovaginal Candidiasis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.0NLRP3, IL4
2positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
3negative regulation of growth of symbiont in hostGO:0441309.8IFNG, MBL2
4positive regulation of chemokine biosynthetic processGO:0450809.8IL4, IFNG
5acute-phase responseGO:0069539.8F2, IL1RN, MBL2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL2, IL4
7chemotaxisGO:0069359.7IL4, DEFB4A, DEFB1
8positive regulation of activated T cell proliferationGO:0421049.7IL2, IL4
9defense response to protozoanGO:0428329.6IL4, IFNG
10positive regulation of isotype switching to IgG isotypesGO:0483049.5IFNG, IL4, IL2
11positive regulation of interleukin-1 beta secretionGO:0507189.4IFNG, NLRP3
12innate immune responseGO:0450879.1NLRP3, MBL2, DEFA5, DEFB1, DEFB4A
13immune responseGO:0069559.1DEFB1, DEFB4A, IL1RN, IL4, IL2
14defense response to bacteriumGO:0427429.0DEFB4A, DEFB1, DEFA5, MBL2, IFNG

Products for genes affiliated with Vulvovaginal Candidiasis

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  • Lysates
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Sources for Vulvovaginal Candidiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet