MCID: VLV010
MIFTS: 53

Vulvovaginitis malady

Summaries for Vulvovaginitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Vaginitis is an inflammation of the vagina. It can result in discharge, itching and pain, and is often... more...

MalaCards: Vulvovaginitis, also known as vulvovaginitis unspecified, is related to vulvovaginal candidiasis and candidiasis. An important gene associated with Vulvovaginitis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Beta defensins. The compounds rantes and estrogen have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and skin, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Vulvovaginitis

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
See all sources

Aliases & Descriptions:

vulvovaginitis 8 44 60
vulvovaginitis unspecified 8
vulvovaginitis nos 8
vulvo-vaginitis 8


External Ids:

Disease Ontology8 DOID:2273
MeSH34 D014848
NCIt39 C35131

Related Diseases for Vulvovaginitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vulvovaginitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1vulvovaginal candidiasis31.7DEFA5
2candidiasis31.6SKAP2, CD79A, DEFB4A
3oral candidiasis30.8SKAP2, DEFB4A
4bacterial vaginosis30.5LAP3, MBL2
5lichen planus30.5DEFB4A
6gingivitis30.5HSPD1
7cervicitis30.0HSPD1
8influenza30.0MBL2, CD79A, HSPA4
9diabetes mellitus30.0GGT1, HLA-DQB1, CD79A, HSPA4, HSPD1
10herpes simplex29.8CD79A
11peritonitis29.8F2
12glomerulonephritis29.8CD79A, MBL2
13typhoid fever29.8CD79A
14infertility29.8CD79A, HSPD1
15salpingitis29.8HSPD1
16deficiency anemia29.8CD79A, F2
17cystic fibrosis29.8MBL2, DEFB1, DEFB4A, LAP3
18adenocarcinoma29.8ACTC1, GGT1, HMGA2, LAP3
19skin disease29.8DEFB4A, HSPA4, IL4, CD79A, IL13
20melanoma29.8DES, HSPA4, HSPD1, LAP3, IL4, ACTC1
21vaginitis10.8
22rhinotracheitis10.6
23vaginal cancer10.3
24granuloma inguinale10.2
25balanoposthitis10.1
26rhabdomyosarcoma10.1
27vaginal discharge10.1
28trichomoniasis10.0
29embryonal rhabdomyosarcoma10.0
30vulvar disease10.0
31vulvovaginal rhabdomyosarcoma10.0
32vulvovaginal gingival syndrome10.0
33crohn's disease10.0DEFA5
34trachoma10.0HSPD1
35urticaria10.0NLRP3
36diarrhea10.0CD79A
37pancreatitis10.0GGT1
38purpura10.0CD79A
39cryoglobulinemia10.0CD79A
40ovarian cancer10.0HSPD1
41sjogren's syndrome10.0CD79A
42urethritis10.0CD79A
43pertussis10.0CD79A
44neuropathy10.0CD79A
45measles10.0CD79A
46q fever10.0CD79A
47cholangitis10.0GGT1
48obesity10.0GGT1
49endometriosis10.0ACTC1
50cholelithiasis10.0GGT1

Graphical network of the top 20 diseases related to Vulvovaginitis:



Diseases related to vulvovaginitis

Clinical Features for Vulvovaginitis

About this section

Drugs & Therapeutics for Vulvovaginitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vulvovaginitis

Drug clinical trials:

Search ClinicalTrials for Vulvovaginitis

Search NIH Clinical Center for Vulvovaginitis

Search CenterWatch for Vulvovaginitis

Genetic Tests for Vulvovaginitis

About this section

Anatomical Context for Vulvovaginitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Vulvovaginitis:

32
Testes, Colon, Skin, Lymph node, Ovary, B cells

Animal Models for Vulvovaginitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Vulvovaginitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.0IL13, TBPL1, NLRP3
2MP:00053799.7HMGA2, IL4, TBPL1, HSPA4
3MP:00053978.9NLRP3, MBL2, HLA-DQB1, CD79A, IL13, IL4
4MP:00053878.7NLRP3, MBL2, HLA-DQB1, DEFB1, CD79A, IL13
5MP:00053768.7DES, HLA-DQB1, MBL2, NLRP3, CD79A, IL13
6MP:00107688.3HSPD1, HSPA4, NLRP3, HLA-DQB1, DEFB1, DES

Publications for Vulvovaginitis

About this section
Sources:
50PubMed
See all sources

Articles related to Vulvovaginitis:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Comment on "management of vulvovaginal lichen planus: a new approach". (24375030)
2014
2
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
3
Management of vulvovaginal lichen planus: a new approach. (23222048)
2013
4
NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response. (24063977)
2013
5
Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis. (23119175)
2012
6
Lactobacillus helveticus HY7801 ameliorates vulvovaginal candidiasis in mice by inhibiting fungal growth and NF-I_B activation. (22735758)
2012
7
Recurrent vulvovaginal candidiasis - current management. (21597520)
2011
8
Multifocal multicentric squamous cell carcinomas arising in vulvovaginal lichen planus. (21427605)
2011
9
Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and I+-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-I_B activation. (21830186)
2011
10
Molecular typing and in vitro fluconazole susceptibility of Candida species isolated from diabetic and nondiabetic women with vulvovaginal candidiasis in India. (21524609)
2011
11
Share with women. Vulvovaginal candidiasis. (20437662)
2010
12
Granular Vulvovaginitis Syndrome in Nelore pubertal and post pubertal replacement heifers under tropical conditions: role of Mycoplasma spp., Ureaplasma diversum and BHV-1. (19319656)
2009
13
Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasis. (19456235)
2009
14
Group A Streptococcus vulvovaginitis in breastfeeding women. (18674653)
2008
15
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
16
An epidemiological study of vulvovaginal candidiasis in women of childbearing age. (17582200)
2007
17
Necrotic vulvovaginitis in dairy cattle in Israel. (17277301)
2007
18
Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)
2005
19
Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. (15041994)
2004
20
Antibiotic-associated Vulvovaginal Candidiasis. (14642189)
2003
21
A serologic test for vulvovaginal candidiasis. (12834949)
2003
22
Itraconazole (SporanoxAr) for vulvovaginal candidiasis. (12432422)
2002
23
Chronic vulvovaginal candidiasis. (11237084)
2001
24
The classic approach to diagnosis of vulvovaginitis: a critical analysis. (11495550)
2001
25
Sexual behaviors and other risk factors for Candida vulvovaginitis. (10957753)
2000
26
The impact of contraceptive methods on the onset of symptomatic vulvovaginal candidiasis within the menstrual cycle. (9215201)
1997
27
Effect of butoconazole nitrate 2% vaginal cream and miconazole nitrate 2% vaginal cream treatments in patients with vulvovaginal candidiasis. (18476119)
1996
28
Chronic vulvovaginal candidiasis: characteristics of women with Candida albicans, C glabrata and no candida. (7490047)
1995
29
Vulvovaginitis and vaginal pH. (1489239)
1992
30
Pathogenesis and treatment of recurrent vulvovaginal candidiasis. (1562688)
1992
31
Psychosocial aspects of chronic, clinically unconfirmed vulvovaginitis. (2053947)
1991
32
Vulvovaginal candidiasis: a study of immediate vs. delayed treatment on patient comfort. (1861799)
1991
33
Comparison of topical fungicides in women suffering from vulvovaginitis. (1818427)
1991
34
Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis. (1877264)
1991
35
Three-day treatment of vulvovaginal candidiasis. (3364485)
1988
36
Recurrent vulvovaginal candidiasis: vaginal epithelial cell susceptibility to Candida albicans adherence. (3517722)
1986
37
Sugar chromatography studies in recurrent Candida vulvovaginitis. (6481700)
1984
38
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
39
Vulvovaginitis in prepubertal girls: the importance of group A Streptococcus. (7041280)
1982
40
Update on chlamydia and mycoplasmas in vulvovaginitis. (581685)
1978
41
Vulvovaginal candidiasis. (980292)
1976
42
MONISTAT: a new fungicide for treatment of vulvovaginal candidiasis. (4429114)
1974
43
Miconazole in the treatment of mycotic vulvovaginitis. (4551031)
1972
44
Placental reaction to the infectious bovine rhinotracheitis-infectious pustular vulvovaginitis virus. (4326100)
1971
45
BOVINE INFECTIOUS PUSTULAR VULVOVAGINITIS IN THE WESTERN UNITED STATES. (14128039)
1964
46
VULVOVAGINITIS IN CHILDREN. (14080874)
1963
47
Vulvovaginitis in childhood. (13851465)
1960
48
Infectious pustular vulvovaginitis of cattle. (13585843)
1958
49
Acute ulcerative vulvovaginitis due to Corynebacterium pyogenes. (13120047)
1954
50
VULVOVAGINITIS IN CHILDREN: AN ACCOUNT OF ITS ETIOLOGY, SYMPTOMATOLOGY AND MANAGEMENT, WITH A SUMMARY OF SIXTY-THREE CASES OCCURRING IN SOUTH AFRICA. (21772499)
1925

Genetic Variations for Vulvovaginitis

About this section

Expression for genes affiliated with Vulvovaginitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vulvovaginitis

Search GEO for disease gene expression data for Vulvovaginitis.

Pathways for genes affiliated with Vulvovaginitis

About this section
Sources:
52R&D Systems, 53Reactome, 29KEGG, 51QIAGEN
See all sources

Compounds for genes affiliated with Vulvovaginitis

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Vulvovaginitis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1rantes4410.5IL4, DEFB4A, MBL2
2estrogen4410.4CD79A, DEFB4A, MBL2
3glutamate4410.4HSPD1, LAP3
4acetylcholine44 49 28 11 2414.4GGT1
5tuberculin4410.4HSPD1, MBL2, CD79A
6acetaminophen44 2 49 11 2414.4IL13, GGT1
7hbd24410.4DEFB4A, DEFB1, DEFA5
8cyclosporin a44 28 5912.4ACTC1, F2, CD79A
9polymyxin b4410.4HSPD1, MBL2, DEFB1, IL4
10glucose4410.4DEFB1, ACTC1, LAP3
11reticulin4410.3DES, CD79A, ACTC1
12penicillin4410.3CD79A, IL13, F2
13polysaccharide4410.3HSPD1, MBL2, CD79A, LAP3
14heparin44 28 11 2413.2IL13, CD79A, DES, DEFB4A
15anti-fungal4410.2SKAP2, CD79A, DEFB4A, MBL2
16praziquantel44 1111.2CD79A, IL13, IL4, GGT1
17oxazolone4410.2IL4, IL13
18p-nitroaniline4410.2LAP3, GGT1
19polyethylene glycol4410.2F2, IL4, CD79A, HSPD1
20mannose4410.1HSPD1, MBL2, DEFB4A, CD79A, IL13
21alpha tocopherol4410.1IL4, IL13, HSPA4
22biotin44 11 2412.1HSPD1, DES, CD79A, IL4, ACTC1
23bleomycin44 1111.1LAP3, IL4, IL13, HSPD1
24carbamazepine44 49 1112.1LST1, CD79A, IL4, GGT1
25nickel44 2411.1IL13, HSPD1
26con a4410.0MBL2, CD79A, IL4
27aspartate4410.0HSPD1, HSPA4, MBL2, F2, SKAP2
28azathioprine44 49 2 1113.0DES, CD79A, IL4, GGT1
29hyaluronic acid44 2411.0DES, CD79A, IL13, F2, GGT1
30aspirin44 49 28 2412.9HSPA4, CD79A, IL13, IL4, F2
31fibrinogen449.9HSPD1, HSPA4, MBL2, DES, CD79A, F2
32dexamethasone44 49 28 1112.9HSPA4, DEFB1, DEFB4A, CD79A, IL13, GGT1
33thyroxine44 2410.9HSPA4, MBL2, CD79A, IL13, IL4, GGT1
34n acetylcysteine449.9HSPD1, HSPA4, CD79A, IL4, F2, GGT1
35indomethacin44 59 28 1112.8HSPD1, HSPA4, CD79A, IL13, IL4, GGT1
36ethanol44 49 11 2412.8HSPD1, MBL2, DES, GGT1, LAP3
37h2o2449.8HSPD1, HSPA4, DES, CD79A, IL13, LAP3
38progesterone44 59 28 11 2413.7HSPD1, HSPA4, MBL2, DEFB4A, DES, ACTC1
39iron44 2410.7HSPD1, HSPA4, DES, ACTC1, GGT1, LAP3
40steroid449.7HSPA4, MBL2, DEFB4A, DES, CD79A, IL13
41doxorubicin44 49 1111.6HMGA2, IL13, DES, HSPA4, HSPD1
42paraffin449.5ACTC1, HSPD1, HSPA4, MBL2, DEFB4A, DES
43dihydrotestosterone44 28 11 2412.5DES, CD79A, IL4, GGT1
44alanine449.5HSPD1, HSPA4, CD79A, IL13, F2, GGT1
45lactate449.5HSPD1, HSPA4, DES, CD79A, IL13, F2
46cysteine449.4HSPD1, MBL2, DEFB4A, DES, CD79A, IL13
47vegf449.4HSPD1, HSPA4, MBL2, DES, CD79A, IL13
48creatinine449.4HSPD1, HSPA4, MBL2, DES, CD79A, F2
49tyrosine449.3HSPD1, MBL2, HLA-DQB1, DEFB4A, DES, IL13
50retinoic acid44 2410.2HSPD1, HSPA4, DEFB1, DEFB4A, DES, CD79A

GO Terms for genes affiliated with Vulvovaginitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Vulvovaginitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6F2, DEFB4A, DEFB1, DEFA5
2extracellular spaceGO:0056159.5MBL2, DEFA5, IL13, IL4, F2, HSPD1

Biological processes related to Vulvovaginitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.3NLRP3, IL4
2regulation of proton transportGO:01015510.3IL4, IL13
3positive regulation of macrophage activationGO:04303210.2HSPD1, IL13
4B cell activationGO:04211310.2SKAP2, CD79A, HSPD1
5negative regulation of astrocyte differentiationGO:04871210.1HMGA2, F2
6defense response to bacteriumGO:04274210.1MBL2, DEFA5, DEFB1, DEFB4A
7response to ethanolGO:04547110.1ACTC1, IL4, IL13
8chaperone-mediated protein complex assemblyGO:05113110.0HSPD1, HSPA4
9B cell proliferationGO:0421009.9HSPD1, CD79A
10innate immune responseGO:0450879.8DEFB4A, DEFB1, DEFA5, MBL2, NLRP3
11immune responseGO:0069559.7IL4, IL13, DEFB4A, DEFB1, HLA-DQB1, LST1

Products for genes affiliated with Vulvovaginitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vulvovaginitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet