Vulvovaginitis disease: drugs, articles, genes, clinical trials

Summaries for Vulvovaginitis

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⁴⁴Wikipedia, ²²MalaCards
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Wikipedia: Vaginitis is an inflammation of the vagina. It can result in discharge, itching and pain, and is often...⁴⁴ more...

MalaCards: Vulvovaginitis, also known as vulvovaginitis unspecified (disorder), is related to vulvovaginal candidiasis and candidiasis. An important gene associated with Vulvovaginitis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and NFAT Signaling and Lymphocyte Interactions. The compounds cyclophosphamide and budesonide have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Descriptions for Vulvovaginitis

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Sources:
⁶Disease Ontology, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ²⁷NCIt, ⁴⁰SNOMED-CT, ²⁴MeSH
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Aliases & Descriptions:

vulvovaginitis ⁶ ⁸ ³² ⁴³

vulvovaginitis unspecified (disorder) ⁶

vulvovaginitis (disorder) ⁶

infective vaginitis ⁴³

vulvovaginitis nos ⁶

vulvo-vaginitis ⁶

External Ids:

NCIt²⁷ C35131

SNOMED-CT⁴⁰ 266655004, 155981006, 198215008 53277000, more

MeSH²⁴ D014848

UMLS⁴³ C0042998

Related Diseases for Vulvovaginitis

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to vulvovaginitis by text searches and GeneDecks gene sharing:

(show top 50) (show all 514)

id	Related Disease	Score	Top Affiliating Genes
1	vulvovaginal candidiasis	33.0	LAP3, CD79A, IL4, MBL2, F2, NLRP3
2	candidiasis	28.4	LAP3, CD79A, IL10, IL13, IL4, IL5
3	vulvar vestibulitis syndrome	27.8	MBL2, ESR1, NLRP3
4	thrombosis	26.6	CD79A, IL10, MBL2, IGHE, F2, HSPD1
5	bacterial vaginosis	26.4	LAP3, IL10, IL4, MBL2, HSPA4, LTF
6	lichen planus	25.7	CD79A, IL10, IL4, IL5, MBL2, HSPA4
7	gingivitis	24.2	CD79A, IL10, IL13, IL4, HSPD1, HLA-DQB1
8	vaginitis	23.4	KIT, LAP3, CD79A, IL10, IL13, IL4
9	tonsillitis	13.6	CD79A, DEFB1, DEFB4A
10	chronic cervicitis	13.5	HSPA4, DEFA5
11	hepatic tuberculosis	13.5	F2, GGT1
12	salpingitis	13.5	CD79A, HSPD1
13	exercise induced anaphylaxis	13.4	CD79A, IGHE
14	glomangiomyoma	13.4	ACTC1, DES
15	infantile myofibromatosis	13.4	ACTC1, DES
16	malignant giant cell tumor of soft parts	13.4	ACTC1, DES
17	neonatal hemochromatosis	13.4	F2, DES
18	myofibroma	13.4	ACTC1, DES
19	pseudosarcomatous fibromatosis	13.4	ACTC1, DES
20	immunodeficiency with hyper igm	13.3	CD79A, IGHE
21	glomangioma	13.3	ACTC1, DES
22	peripheral vascular disease	13.3	CD79A, F2, NLRP3
23	immunodeficiency with hyper igm type 1	13.3	CD79A, IL4, IGHE
24	alport syndrome	13.3	CD79A, DES, GGT1
25	mesangial proliferative glomerulonephritis	13.2	CD79A, MBL2
26	rheumatic fever	13.2	CD79A, MBL2, HLA-DQB1
27	cavernous hemangioma of face	13.2	F2, ACTC1, DES
28	menieres disease	13.2	IL4, HSPA4, HLA-DQB1
29	pure red-cell aplasia	13.2	CD79A, F2, HLA-DQB1
30	microsporidiosis	13.2	LTF, DEFB4A, DEFA5
31	intestinal schistosomiasis	13.2	IL13, IL5
32	syphilis	13.2	CD79A, IGHE, F2
33	short bowel syndrome	13.2	CD79A, IGHE, F2
34	klebsiella	13.2	CD79A, HSPD1, ACTC1
35	retroperitoneal leiomyosarcoma	13.2	KIT, DES
36	myoepithelioma	13.2	HMGA2, ACTC1, DES
37	localized scleroderma	13.2	IL13, IL4, DEFB1, DEFB4A
38	inflammatory myofibroblastic tumor	13.2	HMGA2, ACTC1, DES
39	cryptosporidiosis	13.2	IL4, MBL2, LTF
40	pneumoconiosis	13.2	IL4, MBL2, HLA-DQB1
41	multifocal motor neuropathy	13.1	IL10, IL4
42	lepromatous leprosy	13.1	IL10, IL4, HSPD1
43	selective iga deficiency disease	13.1	CD79A, IL10, IL4
44	primary systemic mycosis	13.1	CD79A, IL10, IL4
45	autoimmune hepatitis	13.1	F2, HSPD1, HLA-DQB1, GGT1
46	pleomorphic adenoma	13.1	HMGA2, ACTC1, DES
47	parotitis	13.1	CD79A, LTF, GGT1
48	cryptococcosis	13.1	IL10, MBL2, F2
49	reactive arthritis	13.1	CD79A, HSPD1, LTF
50	tuberculosis	13.1	IL10, IL4, MBL2

Graphical network of the top 20 diseases related to vulvovaginitis:

Graphical network of diseases related to vulvovaginitis

Clinical Features for Vulvovaginitis

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Drugs & Therapeutics for Vulvovaginitis

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vulvovaginitis

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Anatomical Context for Vulvovaginitis

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Phenotypes for genes affiliated with Vulvovaginitis

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²⁵MGI
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MGI Mouse Phenotypes related to vulvovaginitis:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	GGT1, TBPL1, HMGA2
2	liver/biliary system phenotype	MP:0005370	9.7	KIT, NLRP3
3	digestive/alimentary phenotype	MP:0005381	9.4	ESR1, F2, KIT
4	hematopoietic system phenotype	MP:0005397	9.1	HLA-DQB1, IGHE, IL5, KIT
5	renal/urinary system phenotype	MP:0005367	9.0	NLRP3, ESR1, KIT
6	mortality/aging	MP:0010768	8.8	GGT1, DES, DEFB1, NLRP3, HLA-DQB1, HSPD1
7	immune system phenotype	MP:0005387	8.6	KIT, GGT1, LTF, SKAP2, HLA-DQB1, F2
8	reproductive system phenotype	MP:0005389	8.4	NLRP3, TBPL1, HMGA2, HSPD1, IL4, IL13
9	integument phenotype	MP:0010771	8.3	PGR, NLRP3, HMGA2, F2, IL4, IL13
10	growth/size phenotype	MP:0005378	8.0	GGT1, ACTC1, NLRP3, HMGA2, HSPD1, IL5
11	normal phenotype	MP:0002873	7.9	CD79A, IL10, IL4, F2, HLA-DQB1, NLRP3
12	cellular phenotype	MP:0005384	5.8	PGR, ACTC1, SKAP2, TBPL1, HLA-DQB1, ESR1
13	homeostasis/metabolism phenotype	MP:0005376	4.3	HMGA2, HLA-DQB1, NLRP3, LTF, ACTC1, DES

Publications for genes affiliated with Vulvovaginitis

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³⁵PubMed
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Articles related to vulvovaginitis:

(show all 22)

id	Title	Authors	Year	Affiliating Genes
1	HMGA2 is a sensitive but not specific immunohistochem ical marker of vulvovaginal aggressive angiomyxoma. (20551826)	McCluggage W.G.... McBride H.A.	2010	HMGA2
2	Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study. (20032798)	Bachmann G.A.... Komi J.O.	2010	ESR1
3	Mannan-binding lectin in women with a history of recu rrent vulvovaginal candidiasis. (19910100)	HeniA8 E.... MAYrdh P.A.	2010	MBL2
4	Relationship between recurrent vulvovaginal candidosis and immune mediators in vaginal fluid. (19261373)	Weissenbacher T.M.... Mylonas I.	2009	IL4, IL13, IL5
5	Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. (19254587)	Lev-Sagie A.... Witkin S.S.	2009	NLRP3
6	Recent developments in vulvovaginal pathology. (18637148)	McCluggage W.G.	2009	PGR
7	Study on vaginal production of human defensins and the correlated pathogenetic factors of vulvovaginal candidiasis (19080508)	Wang W.... Hu L.N.	2008	DEFB1, DEFA5, DEFB4A
8	Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis. (18715406)	Donders G.G.... Witkin S.S.	2008	MBL2
9	Preliminary evaluation of a vaginal cream containing lactoferrin in the treatment of vulvovaginal candidosis (18487962)	Costantino D.... Guaraldi C.	2008	LTF
10	Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. (17470593)	Giraldo P.C.... Witkin S.S.	2007	MBL2
11	Vulvovaginal candidiasis in pregnant women with impa ired tolerance for glucose (17697596)	Deng Q.S.... Yang H.X.	2007	GGT1
12	Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis. (17714358)	Lian C.H.... Liu W.D.	2007	SKAP2
13	The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele. (16781300)	Setterfield J.F.... Black M.M.	2006	HLA-DQB1
14	Extragastrointestinal stromal tumors presenting as vulvovaginal/rectovaginal septal masses: a diagnostic pitfall. (16810068)	Lam M.M.... Rubin B.P.	2006	KIT, DES, ACTC1
15	Single-dose fluconazole for vulvovaginal candidiasis: impact on prothrombin time in women taking warfarin. (16449117)	Turrentine M.A.	2006	F2
16	Mannose-binding lectin and vulvovaginal candidiasis. (16256117)	Liu F.... Liu Z.	2006	MBL2
17	Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)	Babula O.... Witkin S.S.	2005	IL4, MBL2
18	Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women. (12942410)	Babula O.... Witkin S.S.	2003	MBL2
19	Circulating heat shock proteins in women with a history of recurrent vulvovaginitis. (10371470)	Giraldo P.C.... Witkin S.S.	1999	HSPD1, HSPA4
20	Vaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis. (10076122)	Giraldo P.... Witkin S.S.	1999	IL10
21	Immunohistochemical study of in vivo and in vitro IgA coating of candida species in vulvovaginal candidiasis. (8039782)	Bohler K.... Reinthaller A.	1994	CD79A
22	Terconazole for the treatment of vulvovaginal candidiasis. (2277372)	Thomason J.L.... Broekhuizen F.F.	1990	LAP3

Genes related to Vulvovaginitis

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¹³GeneCards
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Genes related to vulvovaginitis according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
2	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
3	DEFB1	defensin, beta 1	11.0	Publications
4	LAP3	leucine aminopeptidase 3	11.0	Publications
5	DEFB4A	defensin, beta 4A	11.0	Publications
6	NLRP3	NLR family, pyrin domain containing 3	11.0	Publications
7	SKAP2	src kinase associated phosphoprotein 2	11.0	Publications
8	GGT1	gamma-glutamyltransferase 1	11.0	Publications
9	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
10	HSPA4	heat shock 70kDa protein 4	11.0	Publications
11	IL4	interleukin 4	11.0	Publications
12	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
13	F2	coagulation factor II (thrombin)	11.0	Publications
14	LST1	leukocyte specific transcript 1	11.0
15	TBPL1	TBP-like 1	11.0
16	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
17	HMGA2	high mobility group AT-hook 2	11.0	Publications
18	DES	desmin	11.0	Publications
19	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
20	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
21	LTF	lactotransferrin	11.0	Publications
22	IL13	interleukin 13	11.0	Publications
23	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
24	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
25	PGR	progesterone receptor	11.0	Publications
26	IL10	interleukin 10	11.0	Publications
27	ESR1	estrogen receptor 1	11.0	Publications

Expression for genes affiliated with Vulvovaginitis

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Vulvovaginitis

Pathways for genes affiliated with Vulvovaginitis

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³⁷R&D Systems, ³⁶QIAGEN, ³⁸Reactome, ²⁰KEGG
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Pathways related to vulvovaginitis according to GeneDecks:

(show all 23)

id	Pathway	Score	Top Affiliating Genes
1	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types³⁷	9.6	IL5, IL4, IL13
2	NFAT Signaling and Lymphocyte Interactions³⁶	9.6	IL13, IL4, IL5
3	PGC1Alpha Pathway³⁶	9.5	IL5, IL4, IL13
4	Immune System³⁸	9.4	DEFA5, DEFB4A, DEFB1, NLRP3, IL5, CD79A
5	THC Differentiation Pathway³⁶	9.3	HLA-DQB1, IL4, IL10
6	Allograft rejection²⁰	8.9	IL10, IL4, IL5, HLA-DQB1
7	Intestinal immune network for IgA production²⁰	8.9	HLA-DQB1, IL5, IL4, IL10
8	Autoimmune thyroid disease²⁰	8.9	IL10, IL4, IL5, HLA-DQB1
9	OX40 Pathway³⁶	8.9	IL5, IL4, IL13, IL10
10	Cytokine Network³⁶	8.9	IL5, IL4, IL13, IL10
11	MIF Mediated Glucocorticoid Regulation³⁶	8.8	IL10, IL13, IL4, IL5
12	MIF Regulation of Innate Immune Cells³⁶	8.7	IL5, IL4, IL13, IL10
13	all-trans-Retinoic Acid Signaling in Brain³⁶	8.6	IL5, IL4, IL13, IL10
14	PEDF Induced Signaling³⁶	8.6	IL10, IL13, IL4, IL5
15	Asthma²⁰	8.5	IL10, IL13, IL4, IL5, HLA-DQB1
16	Rho Family GTPases³⁶	8.4	DES, IL4, IL13, IL10, KIT
17	SOCS Pathway³⁶	8.4	IL5, IL4, IL13, IL10
18	Cytokine-cytokine receptor interaction²⁰	8.3	IL5, IL4, IL13, IL10, KIT
19	Jak-STAT signaling pathway²⁰	8.2	IL10, IL13, IL4, IL5
20	Endothelin-1 Signaling Pathway³⁶	8.2	F2, IL5, IL4, IL13, IL10, KIT
21	JAK-STAT Pathway³⁶	8.1	F2, IL5, IL4, IL13, IL10, KIT
22	PAK Pathway³⁶	8.1	IL5, IL4, IL13, IL10, KIT
23	ERK Signaling³⁶	7.5	IL5, IL4, IL13, IL10, KIT, ESR1

Compounds for genes affiliated with Vulvovaginitis

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³²Novoseek , ³⁴PharmGKB, ⁹DrugBank, ⁴²Tocris Bioscience, ¹⁸HMDB
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Compounds related to vulvovaginitis according to GeneDecks:

(show top 50) (show all 166)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide³² ³⁴ ⁹ ⁹	13.4	MBL2, LTF
2	budesonide³² ⁴² ⁹ ⁹	13.1	IGHE, LTF
3	heparin³² ⁹ ¹⁸ ⁹	12.9	CD79A, F2, DEFB4A, DES
4	biotin³² ⁹ ¹⁸ ⁹	12.7	DES, ACTC1, HSPD1, CD79A
5	cysteine³²	9.6	CD79A, IL5, LAP3, LTF
6	omalizumab³² ⁹ ⁹	11.4	IL13, IL4, IL5, IGHE
7	ovomucoid³²	9.3	IGHE, IL5, IL13, IL4
8	anti-fungal³²	9.3	DEFB4A, LTF, SKAP2, MBL2, CD79A, IL5
9	acetaminophen³² ³⁴ ⁹ ¹⁸ ⁹	13.3	F2, GGT1, HSPA4, PGR, IGHE
10	tuberculin³²	9.2	MBL2, IL10, HSPD1, CD79A
11	penicillin³²	9.2	IL5, IL13, IGHE, F2, CD79A
12	polymyxin b³²	9.0	DEFB1, HSPD1, MBL2, IL10, LTF, IL4
13	n acetylcysteine³²	8.9	CD79A, IL4, IGHE, F2, HSPA4, HSPD1
14	con a³²	8.9	IL4, CD79A, IL10, IL5, MBL2
15	methacholine³² ⁹ ⁹	10.8	CD79A, IL5, IL13, IL4, IGHE, LTF
16	polysaccharide³²	8.8	GGT1, LTF, IGHE, MBL2, IL13, CD79A
17	ribavirin³² ³⁴ ⁹ ⁹	11.7	GGT1, LTF, MBL2, IL4, IL10
18	fluticasone propionate³² ⁴² ⁹ ⁹	11.7	IL13, IL4, IL5, PGR, IGHE
19	aspartate³²	8.7	MBL2, LAP3, F2, GGT1, HSPD1, PGR
20	azathioprine³² ³⁴ ⁹ ⁹	11.6	DES, LTF, GGT1, IL10, IL4, CD79A
21	glatiramer acetate³² ⁹ ⁹	10.6	IL5, IL4, IL10, IL13
22	montelukast³² ³⁴ ⁹ ⁹	11.6	IL13, IGHE, IL5, IL4, IL10
23	salbutamol³² ³⁴ ⁹ ¹⁸ ⁹	12.5	IGHE, IL13, IL10, IL5, CD79A
24	allergens³²	8.3	IL10, IL13, IL4, CD79A, IGHE, IL5
25	creatinine³²	8.3	F2, LAP3, CD79A, MBL2, IGHE, GGT1
26	praziquantel³² ⁹ ⁹	10.2	IL10, IL4, IL5, GGT1, IGHE, CD79A
27	rantes³²	8.2	DEFB4A, DEFB1, HSPD1, MBL2, IL5, IL4
28	lactate³²	8.2	DES, GGT1, IGHE, LAP3, KIT, CD79A
29	prednisolone³² ⁹ ⁹	10.2	IL5, IL13, MBL2, IGHE, IL10, CD79A
30	tarc³²	8.1	IL10, IL4, IGHE, IL5, IL13
31	steroid³²	8.1	MBL2, DES, IL13, CD79A, PGR, KIT
32	estrogen³²	8.1	LTF, F2, IGHE, DEFB4A, ESR1, PGR
33	hydrocortisone³² ⁹ ⁹	9.8	IL10, IL4, IL5, IGHE, LTF, IL13
34	progesterone³² ⁴² ⁹ ¹⁸ ⁹	11.8	ESR1, ACTC1, KIT, DES, PGR, HSPA4
35	actinomycin d³²	7.8	IGHE, KIT, IL13, HSPA4, DES, LTF
36	tacrolimus³² ³⁴ ⁹ ⁹	10.8	IL10, IL13, CD79A, GGT1, IL5, PGR
37	doxorubicin³² ³⁴ ⁹ ⁹	10.7	HMGA2, DES, PGR, HSPD1, IL13, KIT
38	vegf³²	7.7	LTF, ESR1, HSPD1, HSPA4, MBL2, LAP3
39	indomethacin³² ⁹ ⁹	9.6	HSPD1, HSPA4, IGHE, IL5, IL4, IL13
40	adenylate³²	7.5	IL5, PGR, HSPA4, HSPD1, IL4, IGHE
41	histamine³² ¹⁸	8.4	CD79A, IL5, IL13, IL10, LTF, DEFB4A
42	glutamine³²	7.3	KIT, HSPA4, HLA-DQB1, LTF, PGR, GGT1
43	thyroxine³² ¹⁸	8.3	MBL2, IL5, IL4, CD79A, GGT1, PGR
44	testosterone³² ⁹ ¹⁸ ⁹	10.2	CD79A, GGT1, PGR, IL5, KIT, IGHE
45	retinoic acid³² ⁴² ¹⁸	9.0	DEFB1, PGR, ESR1, KIT, LAP3, CD79A
46	methotrexate³² ³⁴ ⁴² ⁹ ⁹	10.8	PGR, GGT1, IL5, KIT, CD79A, IL10
47	cyclosporin a³² ⁴²	7.7	PGR, ACTC1, LTF, HSPD1, F2, IGHE
48	cycloheximide³²	6.6	IL5, IL10, IL13, IL4, ESR1, HSPD1
49	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	10.1	CD79A, IL10, IL13, IL4, IL5, MBL2
50	paraffin³²	5.6	PGR, DES, DEFB4A, ACTC1, LTF, HMGA2

GO Terms for genes affiliated with Vulvovaginitis

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¹²Gene Ontology
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Cellular components related to vulvovaginitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	9.5	DEFA5, DEFB4A, DEFB1, F2
2	external side of plasma membrane	GO:009897	9.2	KIT, CD79A, IL13, IL4
3	extracellular space	GO:005615	7.2	KIT, DEFA5, HSPD1, F2, MBL2, IL5

Biological processes related to vulvovaginitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	B cell activation	GO:042113	10.0	SKAP2, HSPD1, CD79A
2	regulation of proton transport	GO:010155	9.9	IL13, IL4
3	regulation of isotype switching	GO:045191	9.6	IL10, IL4
4	type 2 immune response	GO:042092	9.4	IL4, IL10
5	B cell proliferation	GO:042100	9.4	HSPD1, IL10, CD79A
6	positive regulation of B cell proliferation	GO:030890	9.4	IL13, IL4, IL5
7	B cell differentiation	GO:030183	9.1	CD79A, IL10, IL4
8	defense response to bacterium	GO:042742	9.0	IL10, LTF, DEFB1, DEFB4A, DEFA5
9	immune response	GO:006955	8.3	IL13, DEFB4A, DEFB1, LST1, HLA-DQB1, IGHE
10	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.2	ESR1, IL5, IL4, IL10, KIT
11	inflammatory response	GO:006954	7.8	NLRP3, IL5, IL13, IL10, KIT