MCID: VLV010
MIFTS: 53

Vulvovaginitis malady

Summaries for Vulvovaginitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Vaginitis is an inflammation of the vagina. It can result in discharge, itching and pain, and is often... more...

MalaCards: Vulvovaginitis, also known as vulvovaginitis unspecified, is related to vulvovaginal candidiasis and candidiasis. An important gene associated with Vulvovaginitis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Beta defensins. The compounds rantes and estrogen have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and skin, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Vulvovaginitis

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
See all sources

Aliases & Descriptions:

vulvovaginitis 8 44 60
vulvovaginitis unspecified 8
vulvovaginitis nos 8
vulvo-vaginitis 8


External Ids:

Disease Ontology8 DOID:2273
MeSH34 D014848
NCIt39 C35131

Related Diseases for Vulvovaginitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vulvovaginitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1vulvovaginal candidiasis31.7DEFA5
2candidiasis31.6SKAP2, CD79A, DEFB4A
3oral candidiasis30.8SKAP2, DEFB4A
4bacterial vaginosis30.5LAP3, MBL2
5lichen planus30.5DEFB4A
6gingivitis30.5HSPD1
7cervicitis30.0HSPD1
8influenza30.0MBL2, CD79A, HSPA4
9diabetes mellitus30.0GGT1, HLA-DQB1, CD79A, HSPA4, HSPD1
10herpes simplex29.8CD79A
11peritonitis29.8F2
12glomerulonephritis29.8CD79A, MBL2
13typhoid fever29.8CD79A
14infertility29.8CD79A, HSPD1
15salpingitis29.8HSPD1
16deficiency anemia29.8CD79A, F2
17cystic fibrosis29.8MBL2, DEFB1, DEFB4A, LAP3
18adenocarcinoma29.8ACTC1, GGT1, HMGA2, LAP3
19skin disease29.8DEFB4A, HSPA4, IL4, CD79A, IL13
20melanoma29.8DES, HSPA4, HSPD1, LAP3, IL4, ACTC1
21vaginitis10.8
22rhinotracheitis10.6
23vaginal cancer10.3
24granuloma inguinale10.2
25balanoposthitis10.1
26rhabdomyosarcoma10.1
27vaginal discharge10.1
28trichomoniasis10.0
29embryonal rhabdomyosarcoma10.0
30vulvar disease10.0
31vulvovaginal rhabdomyosarcoma10.0
32vulvovaginal gingival syndrome10.0
33crohn's disease10.0DEFA5
34trachoma10.0HSPD1
35urticaria10.0NLRP3
36diarrhea10.0CD79A
37pancreatitis10.0GGT1
38purpura10.0CD79A
39cryoglobulinemia10.0CD79A
40ovarian cancer10.0HSPD1
41sjogren's syndrome10.0CD79A
42urethritis10.0CD79A
43pertussis10.0CD79A
44neuropathy10.0CD79A
45measles10.0CD79A
46q fever10.0CD79A
47cholangitis10.0GGT1
48obesity10.0GGT1
49endometriosis10.0ACTC1
50cholelithiasis10.0GGT1

Graphical network of the top 20 diseases related to Vulvovaginitis:



Diseases related to vulvovaginitis

Clinical Features for Vulvovaginitis

About this section

Drugs & Therapeutics for Vulvovaginitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vulvovaginitis

Drug clinical trials:

Search ClinicalTrials for Vulvovaginitis

Search NIH Clinical Center for Vulvovaginitis

Search CenterWatch for Vulvovaginitis

Genetic Tests for Vulvovaginitis

About this section

Anatomical Context for Vulvovaginitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Vulvovaginitis:

32
Testes, Colon, Skin, Lymph node, Ovary, B cells

Animal Models for Vulvovaginitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Vulvovaginitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.0IL13, TBPL1, NLRP3
2MP:00053799.7HMGA2, IL4, TBPL1, HSPA4
3MP:00053978.9NLRP3, MBL2, HLA-DQB1, CD79A, IL13, IL4
4MP:00053878.7NLRP3, MBL2, HLA-DQB1, DEFB1, CD79A, IL13
5MP:00053768.7DES, HLA-DQB1, MBL2, NLRP3, CD79A, IL13
6MP:00107688.3HSPD1, HSPA4, NLRP3, HLA-DQB1, DEFB1, DES

Publications for Vulvovaginitis

About this section
Sources:
50PubMed
See all sources

Articles related to Vulvovaginitis:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
2
Antifungal efficacy of propolis against fluconazole-resistant Candida glabrata isolates obtained from women with recurrent vulvovaginal candidiasis. (21669419)
2011
3
The recurrent vulvovaginal candidiasis: proposal of a personalized therapeutic protocol. (21845227)
2011
4
Prevalence of bacterial vaginosis and vulvovaginal candidiasis mixed infection in a southeastern american STD clinic. (21844715)
2011
5
Diagnosis of vulvovaginitis: comparison of clinical and microbiological diagnosis. (20461391)
2010
6
Relationship between clinical diagnosis of recurrent vulvovaginal candidiasis and detection of Candida species by culture and polymerase chain reaction. (18506464)
2009
7
Efficient diagnosis of vulvovaginal candidiasis by use of a new rapid immunochromatography test. (19794036)
2009
8
Epidemiology and eradication of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) virus in Finland. (17222341)
2007
9
Recurrent vulvovaginal candidiasis. (16703718)
2006
10
Management of recurrent vulvovaginal candidiasis: unresolved issues. (17064642)
2006
11
Childhood vulvovaginitis: report of two cases. (17016969)
2006
12
The epidemiology of mycotic vulvovaginitis and the use of antifungal agents in suspected mycotic vulvovaginitis and its implications for clinical practice. (16209225)
2005
13
Trends in prescribing for vulvovaginal candidiasis in the United States. (15386715)
2005
14
Effect of lactobacillus in preventing post-antibiotic vulvovaginal candidiasis: a randomised controlled trial. (15333452)
2004
15
Clinical resistance of recurrent Candida albicans vulvovaginitis to fluconazole in the presence and absence of in vitro resistance. (12621787)
2003
16
Incident and persistent vulvovaginal candidiasis among human immunodeficiency virus-infected women: Risk factors and severity. (12636961)
2003
17
Erosive Vulvovaginitis. (14642191)
2003
18
Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women. (12237629)
2002
19
Lichen Sclerosus and Other Conditions Mimicking Vulvovaginal Candidiasis. (12433328)
2002
20
Acute glomerulonephritis with group A streptococcal vulvovaginitis. (11156071)
2000
21
Susceptibility of Candida species isolated from female prostitutes with vulvovaginitis to antifungal agents and boric acid. (10192716)
1999
22
Effect of antibiotic use on the prevalence of symptomatic vulvovaginal candidiasis. (9914570)
1999
23
Treatment of vulvovaginal candidiasis in patients with diabetes. (9540031)
1998
24
Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus. (9166302)
1997
25
Immune compromise and prevalence of Candida vulvovaginitis in human immunodeficiency virus-infected women. (9241304)
1997
26
Is vulvovaginal candidiasis an AIDS-related illness? (8722839)
1996
27
The impact of oral contraception on vulvovaginal candidiasis. (7628203)
1995
28
Vulvovaginal candidiasis: topical vs. oral therapy. (7754931)
1995
29
Controversial aspects in the management of vulvovaginal candidiasis. (8077494)
1994
30
The identification of Mycoplasma mycoides mycoides LC as the aetiological agent of balanoposthitis and vulvovaginitis in sheep in South Africa. (8392679)
1993
31
Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison. (1941796)
1991
32
Fungal vulvovaginitis. (1818723)
1991
33
Vulvovaginal candidiasis complicating recurrent bacterial vaginosis. (2305336)
1990
34
Comparison of 0.8% and 1.6% terconazole cream in severe vulvovaginal candidiasis. (2381618)
1990
35
Drugs for treatment of vulvovaginal candidiasis: comparative efficacy of agents and regimens. (2275233)
1990
36
Candida tropicalis vulvovaginitis. (3895072)
1985
37
Herpetic vulvovaginitis and child abuse. (4039884)
1985
38
Efficacy and tolerability of single-dose versus six-day treatment of candidal vulvovaginitis with vaginal tablets of clotrimazole. (3895960)
1985
39
Vaginal organisms in prepubertal children with and without vulvovaginitis. A vaginoscopic study. (6751240)
1982
40
Treatment of fungal vulvovaginitis with Canesten. (751276)
1978
41
Vulvovaginal candidiasis in pregnancy treated with clotrimazole. (364918)
1978
42
Premenarchal vulvovaginitis. (891056)
1977
43
An outbreak of infectious pustular vulvovaginitis in beef heifers vaccinated against infectious bovine rhinotracheitis. (199977)
1977
44
Vulvovaginitis and vaginal discharge in general practice. (1223281)
1975
45
Monistat cream (miconazole nitrate) a new agent for the treatment of vulvovaginal candidiasis. (765457)
1975
46
The therapy of candida vaginitis and candida vulvovaginitis with a new antimycotic substance, clotrimazole. (4591822)
1973
47
Vulvovaginitis in a child. (4688935)
1973
48
Serum neutralization tests with infectious bovine rhinotracheitis-infectious pustular vulvovaginitis (IBR-IPV) virus. (4346980)
1972
49
Comparative studies of a Canadian strain with New York strains of infectious pustular vulvovaginitis virus and with infectious bovine rhinotracheitis virus. (13663574)
1959
50
The treatment of mycotic vulvovaginitis with propionate vaginal jelly. (20286636)
1947

Genetic Variations for Vulvovaginitis

About this section

Expression for genes affiliated with Vulvovaginitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vulvovaginitis

Search GEO for disease gene expression data for Vulvovaginitis.

Pathways for genes affiliated with Vulvovaginitis

About this section
Sources:
52R&D Systems, 53Reactome, 29KEGG, 51QIAGEN
See all sources

Compounds for genes affiliated with Vulvovaginitis

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Vulvovaginitis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1rantes4410.5MBL2, DEFB4A, IL4
2estrogen4410.4DEFB4A, MBL2, CD79A
3glutamate4410.4LAP3, HSPD1
4acetylcholine44 49 28 11 2414.4GGT1
5tuberculin4410.4CD79A, MBL2, HSPD1
6acetaminophen44 2 49 11 2414.4GGT1, IL13
7hbd24410.4DEFA5, DEFB4A, DEFB1
8cyclosporin a44 28 5912.4CD79A, F2, ACTC1
9polymyxin b4410.4IL4, DEFB1, MBL2, HSPD1
10glucose4410.4DEFB1, LAP3, ACTC1
11reticulin4410.3ACTC1, DES, CD79A
12penicillin4410.3CD79A, F2, IL13
13polysaccharide4410.3CD79A, LAP3, HSPD1, MBL2
14oxazolone4410.2IL13, IL4
15heparin44 28 11 2413.2DEFB4A, DES, CD79A, IL13
16anti-fungal4410.2DEFB4A, CD79A, MBL2, SKAP2
17praziquantel44 1111.2IL4, GGT1, CD79A, IL13
18polyethylene glycol4410.2IL4, CD79A, HSPD1, F2
19mannose4410.1HSPD1, MBL2, DEFB4A, CD79A, IL13
20alpha tocopherol4410.1IL4, IL13, HSPA4
21p-nitroaniline4410.1LAP3, GGT1
22biotin44 11 2412.1IL4, CD79A, ACTC1, DES, HSPD1
23bleomycin44 1111.1IL13, IL4, LAP3, HSPD1
24carbamazepine44 49 1112.1CD79A, IL4, LST1, GGT1
25nickel44 2411.1HSPD1, IL13
26con a4410.0CD79A, MBL2, IL4
27aspartate4410.0SKAP2, HSPA4, MBL2, F2, HSPD1
28azathioprine44 49 2 1113.0IL4, GGT1, DES, CD79A
29hyaluronic acid44 2411.0CD79A, DES, F2, IL13, GGT1
30aspirin44 49 28 2412.9IL4, IL13, CD79A, HSPA4, F2
31fibrinogen449.9MBL2, HSPD1, CD79A, HSPA4, DES, F2
32dexamethasone44 49 28 1112.9IL13, GGT1, CD79A, DEFB4A, DEFB1, HSPA4
33thyroxine44 2410.9MBL2, GGT1, HSPA4, IL4, IL13, CD79A
34n acetylcysteine449.9HSPD1, HSPA4, CD79A, IL4, F2, GGT1
35indomethacin44 59 28 1112.8HSPD1, HSPA4, IL13, IL4, GGT1, CD79A
36ethanol44 49 11 2412.8HSPD1, GGT1, MBL2, DES, LAP3
37h2o2449.8HSPA4, CD79A, HSPD1, DES, LAP3, IL13
38iron44 2410.7LAP3, ACTC1, DES, HSPA4, HSPD1, GGT1
39progesterone44 59 28 11 2413.7ACTC1, HSPA4, MBL2, HSPD1, DEFB4A, DES
40steroid449.7DES, IL13, ACTC1, CD79A, HSPA4, MBL2
41doxorubicin44 49 1111.6HMGA2, HSPA4, HSPD1, IL13, DES
42paraffin449.5HSPD1, HSPA4, MBL2, DEFB4A, DES, CD79A
43dihydrotestosterone44 28 11 2412.5DES, CD79A, IL4, GGT1
44alanine449.5LAP3, GGT1, F2, IL13, HSPD1, CD79A
45lactate449.5CD79A, LAP3, GGT1, F2, HSPA4, HSPD1
46cysteine449.4CD79A, HSPD1, LAP3, DEFB4A, GGT1, IL4
47vegf449.4CD79A, HSPA4, HSPD1, IL13, LAP3, ACTC1
48creatinine449.4LAP3, GGT1, ACTC1, HSPA4, F2, DES
49tyrosine449.3DES, DEFB4A, SKAP2, ACTC1, IL13, IL4
50retinoic acid44 2410.2DES, LAP3, ACTC1, HMGA2, IL13, CD79A

GO Terms for genes affiliated with Vulvovaginitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Vulvovaginitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6F2, DEFB4A, DEFB1, DEFA5
2extracellular spaceGO:0056159.5MBL2, DEFA5, IL13, IL4, F2, HSPD1

Biological processes related to Vulvovaginitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.3NLRP3, IL4
2regulation of proton transportGO:01015510.3IL4, IL13
3positive regulation of macrophage activationGO:04303210.2HSPD1, IL13
4B cell activationGO:04211310.2SKAP2, CD79A, HSPD1
5negative regulation of astrocyte differentiationGO:04871210.1HMGA2, F2
6defense response to bacteriumGO:04274210.1MBL2, DEFA5, DEFB1, DEFB4A
7response to ethanolGO:04547110.1ACTC1, IL4, IL13
8chaperone-mediated protein complex assemblyGO:05113110.0HSPD1, HSPA4
9B cell proliferationGO:0421009.9HSPD1, CD79A
10innate immune responseGO:0450879.8DEFB4A, DEFB1, DEFA5, MBL2, NLRP3
11immune responseGO:0069559.7IL4, IL13, DEFB4A, DEFB1, HLA-DQB1, LST1

Products for genes affiliated with Vulvovaginitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vulvovaginitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet