MCID: WLD002
MIFTS: 49

Waldenstrom Macroglobulinemia malady

Rare diseases, Immune diseases categories
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Summaries for Waldenstrom Macroglobulinemia

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. it usually affects older adults and is primarily found in the bone marrow, although lymph nodes and the spleen may be involved. affected individuals have a high level of an antibody called immunoglobulin m (igm) in their blood, which can cause thickening of the blood (hyperviscosity). although some individuals initially do not have symptoms and are diagnosed from routine blood work, common symptoms may include weakness, appetite loss and weight loss. other symptoms may include peripheral neuropathy, fever, raynaud's phenomenon, and mental status changes. hyperviscosity of the blood may cause nosebleeds, headaches, dizziness, and blurring or loss of vision. the cause of the condition is not known but environmental, genetic, and viral factors have been suggested. there have been some reports of familial cases suggesting a genetic predisposition. treatment is often reserved for those with symptoms and may include various medications including corticosteroids, alkylating agents, biologic response modifiers and purine analogues. last updated: 10/1/2013

MalaCards: Waldenstrom Macroglobulinemia, also known as lymphoplasmacytic lymphoma, is related to myeloma and cryoglobulinemia. An important gene associated with Waldenstrom Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Malaria and Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway. The drugs cyclophosphamide and thalidomide and the compounds blys and abciximab have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spleen, and related mouse phenotypes are normal and skeleton.

Aliases & Classifications for Waldenstrom Macroglobulinemia

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43NIH Rare Diseases, 45Novoseek, 31LifeMap Discovery™, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

waldenstrom macroglobulinemia 43 45 31 62
lymphoplasmacytic lymphoma 43 62
waldenstrom's macroglobulinaemia 43
macroglobulinemia of waldenstrom 43
waldenstrom's syndrome 43


Related Diseases for Waldenstrom Macroglobulinemia

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17GeneCards, 18GeneDecks
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Diseases in the Waldenstrom Macroglobulinemia family:

Macroglobulinemia, Waldenstrom 2 Macroglobulinemia, Waldenstrom 1

Diseases related to Waldenstrom Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.7CD40LG, IGHM, IRF4, CD40
2cryoglobulinemia30.6CD40LG
3multiple myeloma30.6CD40, IRF4
4leukemia30.3CD40, CD40LG, IRF4, ZAP70
5macroglobulinemia, waldenstrom, somatic30.3HAS1, IRF4, MS4A1, ZAP70, CD40LG, CD40
6chronic lymphocytic leukemia30.1CD40, CD40LG, ZAP70, MS4A1, IGHM
7non-hodgkin lymphoma30.1CD40, MS4A1, IRF4
8b-cell lymphomas30.1IRF4, ZAP70, MS4A1, IGHM, CD40
9malt lymphoma30.0IGHM, IRF4, ZAP70, CD40
10follicular lymphoma29.9CD40, ZAP70, MS4A1, IGHM, IRF4
11macroglobulinemia11.2
12lymphoplasmacytic lymphoma10.5
13histiocytosis10.3
14hepatitis c10.2
15aplastic anemia10.2
16polycythemia vera10.2
17central retinal vein occlusion10.2
18protein-losing enteropathy10.2
19diffuse large b-cell lymphoma10.2
20mantle cell lymphoma10.2
21poems syndrome10.2
22amyloidosis10.2
23hairy cell leukemia10.2
24hematologic cancer10.2
25hepatitis10.2
26hypertension10.2
27pancreatitis10.2
28polycythemia10.2
29retinal vein occlusion10.2
30retinitis10.2
31eosinophilic colitis10.2
32intestinal lymphangiectasia10.2
33cd40 ligand deficiency10.1CD40LG
34neurofibromatosis10.1
35evans' syndrome10.1
36ureteral obstruction10.1
37peliosis hepatis10.1
38gamma heavy chain disease10.1
39nocardiosis10.1
40hemoglobinuria10.1
41polyarteritis nodosa10.1
42cerebritis10.1
43wiskott-aldrich syndrome10.1
44renal tubular acidosis10.1
45heavy chain disease10.1
46nephrotic syndrome10.1
47thyroiditis10.1
48cold agglutinin disease10.1
49macrophage activation syndrome10.1
50mastocytosis10.1

Graphical network of the top 20 diseases related to Waldenstrom Macroglobulinemia:



Diseases related to waldenstrom macroglobulinemia

Symptoms for Waldenstrom Macroglobulinemia

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Drugs & Therapeutics for Waldenstrom Macroglobulinemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Waldenstrom Macroglobulinemia

Search NIH Clinical Center for Waldenstrom Macroglobulinemia

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Waldenstrom Macroglobulinemia cell therapies at LifeMap Discovery.

Genetic Tests for Waldenstrom Macroglobulinemia

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Anatomical Context for Waldenstrom Macroglobulinemia

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33MalaCards
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MalaCards organs/tissues related to Waldenstrom Macroglobulinemia:

33
Bone, Bone marrow, Spleen, Lymph node, B cells, Heart, T cells

Animal Models for Waldenstrom Macroglobulinemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Waldenstrom Macroglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3CD40, ZAP70, IGHM, HAS1
2MP:00053908.0IGHM, ZAP70, CD40LG, CD40
3MP:00053977.1CD40, CD40LG, ZAP70, MS4A1, IRF4, IGHM
4MP:00053877.0IGHM, IRF4, MS4A1, ZAP70, CD40LG, CD40

Publications for Waldenstrom Macroglobulinemia

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52PubMed
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Articles related to Waldenstrom Macroglobulinemia:

(show top 50)    (show all 105)
idTitleAuthorsYear
1
Characterization of subpopulation lacking both B-cell and plasma cell markers in Waldenstrom macroglobulinemia cell line. (24189269)
2014
2
Waldenstrom macroglobulinemia presenting as isolated persistent epistaxis: a very rare presentation. (24427564)
2013
3
A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia. (23773449)
2013
4
Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. (23355206)
2013
5
Genome wide SNP array identified multiple mechanisms of genetic changes in Waldenstrom macroglobulinemia. (23861223)
2013
6
Primary therapy of Waldenstrom macroglobulinemia (WM) with weekly bortezomib, low-dose dexamethasone, and rituximab (BDR): long-term results of a phase 2 study of the European Myeloma Network (EMN). (24004667)
2013
7
Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenstrom macroglobulinemia. (22896002)
2012
8
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. (22976953)
2012
9
Fludarabine plus cyclophosphamide and rituximab in Waldenstrom macroglobulinemia: an effective but myelosuppressive regimen to be offered to patients with advanced disease. (21732338)
2012
10
Waldenstrom macroglobulinemia with a durable clinical response to epoetin beta. (22260157)
2012
11
Concomitant Waldenstrom macroglobulinemia and IgA plasmablastic myeloma in a patient with untreated IgM paraproteinemia: sequential development of biclonal B-cell neoplasms over a 10-year period in a single individual. (22404949)
2012
12
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
13
FGFR3 is overexpressed waldenstrom macroglobulinemia and its inhibition by Dovitinib induces apoptosis and overcomes stroma-induced proliferation. (21521775)
2011
14
Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy. (21350089)
2011
15
The role of serum immunoglobulin free light chain in response and progression in waldenstrom macroglobulinemia. (21415221)
2011
16
Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenstrom macroglobulinemia. (21220746)
2011
17
Successful treatment of eosinophilic colitis by montelukast sodium plus budesonide in a patient with Waldenstrom macroglobulinemia. (21575902)
2011
18
New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia. (21519243)
2011
19
The bone marrow microenvironment in waldenstrom macroglobulinemia. (23556094)
2011
20
Targeting the bone marrow in Waldenstrom macroglobulinemia. (22035751)
2011
21
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
22
microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia. (20519629)
2010
23
Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia. (20110419)
2010
24
Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relapsed and refractory Waldenstrom macroglobulinemia. (20142586)
2010
25
High-dose therapy and autologous stem-cell transplantation in Waldenstrom macroglobulinemia: the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. (20368570)
2010
26
Successful treatment with rituximab and thalidomide of POEMS syndrome associated with Waldenstrom macroglobulinemia. (20673674)
2010
27
Review of clinical trials conducted in Waldenstrom macroglobulinemia and recommendations for reporting clinical trial responses in these patients. (20795787)
2010
28
Immune-related and inflammatory conditions and risk of lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia. (20181958)
2010
29
Expression of regulatory genes for lymphoplasmacytic cell differentiation in Waldenstrom Macroglobulinemia. (19220283)
2009
30
International prognostic scoring system for Waldenstrom macroglobulinemia. (19196866)
2009
31
Simultaneously significant hepatic and mild splenic uptake of Tc-99m MDP resulting from Waldenstrom macroglobulinemia. (19542951)
2009
32
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. (18448868)
2008
33
Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in Sweden. (18703425)
2008
34
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. (18815290)
2008
35
Development of EBV-associated diffuse large B-cell lymphoma in Waldenstrom macroglobulinemia and mantle cell lymphoma. (18608870)
2008
36
Fludarabine, cyclophosphamide and rituximab (FCR) induced pulmonary hypertension in Waldenstrom macroglobulinemia. (18452089)
2008
37
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
38
Recognizing hyperviscosity syndrome in patients with Waldenstrom macroglobulinemia. (17441400)
2007
39
Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia. (17632262)
2007
40
Proteomic analysis of waldenstrom macroglobulinemia. (17440091)
2007
41
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. (17761832)
2007
42
Analysis of 6q deletion in Waldenstrom macroglobulinemia. (17655703)
2007
43
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
44
Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery. (16317092)
2006
45
Treatment of 72 newly diagnosed Waldenstrom macroglobulinemia cases with oral melphalan, cyclophosphamide, and prednisone: results and cost analysis. (15611977)
2005
46
Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia: an evolving concept. (16210920)
2005
47
Initial immunoglobulin M 'flare' after rituximab therapy in patients diagnosed with Waldenstrom macroglobulinemia: an Eastern Cooperative Oncology Group Study. (15493038)
2004
48
A case of t(8;14) with total and partial trisomy 3 in Waldenstrom macroglobulinemia. (9595048)
1998
49
Treatment of Waldenstrom macroglobulinemia with 2-chlorodeoxyadenosine. (8093333)
1993
50
Pulmonary manifestations of Waldenstrom macroglobulinemia. (6776807)
1980

Variations for Waldenstrom Macroglobulinemia

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Expression for genes affiliated with Waldenstrom Macroglobulinemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Waldenstrom Macroglobulinemia

Search GEO for disease gene expression data for Waldenstrom Macroglobulinemia.

Pathways for genes affiliated with Waldenstrom Macroglobulinemia

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50PathCards, 30KEGG, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems
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Compounds for genes affiliated with Waldenstrom Macroglobulinemia

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1blys459.8CD40, CD40LG
2abciximab45 1110.8CD40, CD40LG
3clopidogrel45 51 24 1112.8CD40, CD40LG
4mycophenolate mofetil45 51 1111.8CD40, CD40LG
5fenofibrate45 51 1111.8CD40, CD40LG
6ivig459.7CD40, CD40LG
7neopterin459.7CD40LG, CD40
8allergens459.7CD40, CD40LG
9ganglioside459.7CD40, CD40LG
10pravastatin45 51 29 24 1113.6CD40LG, CD40
11biotin45 24 1111.6CD40, CD40LG
12fluorochrome459.5CD40LG, ZAP70
13okt3459.5ZAP70, CD40LG
14atorvastatin45 51 29 24 1113.5CD40LG, CD40
15herbimycin a45 6110.5CD40, CD40LG
16hydrocortisone45 3 61 1112.5CD40, HAS1
17hyaluronic acid45 2410.5CD40, CD40LG, HAS1
18paraffin459.3CD40, CD40LG, MS4A1
19cytidine45 24 1111.0CD40, CD40LG, ZAP70
20genistein45 29 61 3 24 1114.0ZAP70, CD40LG, CD40
21cyclophosphamide45 51 1111.0MS4A1, ZAP70, CD40
22dexamethasone45 51 29 1111.7CD40, CD40LG, ZAP70
23fludarabine45 51 1110.5CD40, CD40LG, ZAP70, MS4A1
24rituximab45 51 1110.5MS4A1, ZAP70, CD40LG, CD40
25adp45 29 2410.4CD40, CD40LG, ZAP70

GO Terms for genes affiliated with Waldenstrom Macroglobulinemia

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16Gene Ontology
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Cellular components related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD40, CD40LG, MS4A1
2integral component of plasma membraneGO:0058878.3HAS1, MS4A1, CD40LG, CD40
3plasma membraneGO:0058867.9CD40, CD40LG, ZAP70, IGHM, HAS1

Biological processes related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:0510239.6CD40, CD40LG
2positive regulation of endothelial cell apoptotic processGO:20003539.6CD40, CD40LG
3positive regulation of interleukin-12 productionGO:0327359.5CD40LG, CD40
4regulation of immune responseGO:0507769.5CD40, CD40LG
5adaptive immune responseGO:0022509.1ZAP70, IGHM
6B cell proliferationGO:0421009.1CD40, CD40LG, MS4A1
7T cell activationGO:0421108.7ZAP70, IRF4

Molecular functions related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.5CD40, IGHM

Products for genes affiliated with Waldenstrom Macroglobulinemia

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  • Antibodies
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Sources for Waldenstrom Macroglobulinemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet