Waldenstrom Macroglobulinemia malady

Immune diseases category

Summaries for Waldenstrom Macroglobulinemia

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. it usually affects older adults and is primarily found in the bone marrow, although lymph nodes and the spleen may be involved. affected individuals have a high level of an antibody called immunoglobulin m (igm) in their blood, which can cause thickening of the blood (hyperviscosity). although some individuals initially do not have symptoms and are diagnosed from routine blood work, common symptoms may include weakness, appetite loss and weight loss. other symptoms may include peripheral neuropathy, fever, raynaud's phenomenon, and mental status changes. hyperviscosity of the blood may cause nosebleeds, headaches, dizziness, and blurring or loss of vision. the cause of the condition is not known but environmental, genetic, and viral factors have been suggested. there have been some reports of familial cases suggesting a genetic predisposition. treatment is often reserved for those with symptoms and may include various medications including corticosteroids, alkylating agents, biologic response modifiers and purine analogues. last updated: 10/1/2013

MalaCards: Waldenstrom Macroglobulinemia, also known as lymphoplasmacytic lymphoma, is related to macroglobulinemia and myeloma. An important gene associated with Waldenstrom Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Primary immunodeficiency and Glial Cell Differentiation. The drugs cyclophosphamide and thalidomide and the compounds 8-chloroadenosine and fluorochrome have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lymph node, and related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Waldenstrom Macroglobulinemia

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42NIH Rare Diseases, 60UMLS, 44Novoseek, 30LifeMap Discovery™
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Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases

Aliases & Descriptions:

waldenstrom macroglobulinemia 42 44 30 60
lymphoplasmacytic lymphoma 42 60
waldenstrom's macroglobulinaemia 42
macroglobulinemia of waldenstrom 42
waldenstrom's syndrome 42

Related Diseases for Waldenstrom Macroglobulinemia

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17GeneCards, 18GeneDecks
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Diseases in the Waldenstrom Macroglobulinemia family:

Macroglobulinemia, Waldenstrom 2 Macroglobulinemia, Waldenstrom 1

Diseases related to Waldenstrom Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.7MAG, PAX5
2myeloma30.7PTPRC, PAX5, BIRC3, CD27, CD40LG, CD40
3multiple myeloma30.6CD40, IRF4, CCND1
4macroglobulinemia, waldenstrom, somatic30.5PAX5, PTPRC, ADA, MS4A1, BIRC3, CD40
5leukemia30.4PAX5, BIRC3, IRF4, CD40LG, CD40, ZAP70
7hepatitis c30.3IGHM, CD40LG, PAX5
8non-hodgkin lymphoma30.3ADA, PTPRC, PAX5, MS4A1, BIRC3, CD59
10hairy cell leukemia30.2CCND1, CD40, PTPRC, ADA
11hematologic cancer30.2ZAP70, PAX5, ADA
12chronic lymphocytic leukemia30.2CCND1, TNFRSF17, ZAP70, IGHM, CD40, CD70
13bone lymphoma10.5
14lymphoplasmacytic lymphoma10.4
16liver lymphoma10.2
17aplastic anemia10.2
18polycythemia vera10.1
19central retinal vein occlusion10.1
20protein-losing enteropathy10.1
21poems syndrome10.1
22mantle cell lymphoma10.1
23diffuse large b-cell lymphoma10.1
29retinal vein occlusion10.1
32ureteral obstruction10.0
33evans' syndrome10.0
34thyroid lymphoma10.0
36wiskott-aldrich syndrome10.0
37peliosis hepatis10.0
38polyarteritis nodosa10.0
41gamma heavy chain disease10.0
42nasal cavity lymphoma10.0
43lung lymphoma10.0
44cerebral lymphoma10.0
45composite lymphoma10.0
46ureteral lymphoma10.0
47spinal cord lymphoma10.0
48renal tubular acidosis10.0
49retroperitoneal lymphoma10.0
50splenic marginal zone lymphoma10.0

Graphical network of the top 20 diseases related to Waldenstrom Macroglobulinemia:

Diseases related to waldenstrom macroglobulinemia

Clinical Features for Waldenstrom Macroglobulinemia

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Drugs & Therapeutics for Waldenstrom Macroglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Waldenstrom Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Waldenstrom Macroglobulinemia

Search NIH Clinical Center for Waldenstrom Macroglobulinemia

Search CenterWatch for Waldenstrom Macroglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Waldenstrom Macroglobulinemia cell therapies at LifeMap Discovery.

Genetic Tests for Waldenstrom Macroglobulinemia

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Anatomical Context for Waldenstrom Macroglobulinemia

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MalaCards organs/tissues related to Waldenstrom Macroglobulinemia:

Bone, Bone marrow, Lymph node, Spleen

Animal Models for Waldenstrom Macroglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Waldenstrom Macroglobulinemia:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CD59, IGHM
2MP:00028739.9CCND1, TNFRSF17, HAS1, ZAP70, IGHM, CD40
3MP:00053909.9CCND1, IGHM, CD40, CD40LG, PAX5, PTPRC
4MP:00053849.7CD40, IGHM, ZAP70, IRF4, CCND1, CD40LG
5MP:00053979.7ADA, CCND1, TNFRSF17, IRF4, ZAP70, IGHM
6MP:00053879.6IGHM, ZAP70, STOML2, IRF4, TNFRSF17, CCND1

Publications for Waldenstrom Macroglobulinemia

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Genetic Variations for Waldenstrom Macroglobulinemia

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Expression for genes affiliated with Waldenstrom Macroglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Waldenstrom Macroglobulinemia

Search GEO for disease gene expression data for Waldenstrom Macroglobulinemia.

Pathways for genes affiliated with Waldenstrom Macroglobulinemia

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 55SinoBiological
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Pathways related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ADA, ZAP70
210.3MIR206, MAG
310.3ZAP70, CD40, CD40LG
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10.3CD40, CD40LG, CD59
510.3CD40, CD40LG, PTPRC
610.3BIRC3, CD40LG, CD40
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10.3IRF4, ZAP70, CD40LG, PTPRC
810.3ZAP70, CD40, CD40LG, BIRC3
Apoptosis and survival Apoptotic TNF-family pathways
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10.3BIRC3, CD27, CD70
1010.3MAG, CD40, CD40LG, PTPRC
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10.2CD40LG, CD40, TNFRSF17, CCND1
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.2TNFRSF17, CD40, CD40LG, BIRC3
1310.2ADA, PAX5, BIRC3, CCND1
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10.2CD27, CD40LG, CD70, CD40, TNFRSF17
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10.1IRF4, ZAP70, IGHM, CD40, CD40LG, CD59
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10.1TNFRSF17, CD40, CD70, CD40LG, CD27, BIRC3

Compounds for genes affiliated with Waldenstrom Macroglobulinemia

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
18-chloroadenosine4410.7CCND1, ADA
2fluorochrome4410.7PTPRC, CD40LG, ZAP70
3blys4410.7CD40LG, CD40, TNFRSF17
4bcma4410.7CD27, CD40, TNFRSF17
5fitc4410.7PTPRC, CD59, ZAP70
6serine4410.7CCND1, MAG, BIRC3
7hyaluronic acid44 2411.6PTPRC, CD40LG, CD40, HAS1
8cytidine44 11 2412.6ZAP70, CD40, CD40LG, PAX5, ADA
9formaldehyde44 2411.6CCND1, ZAP70, CD40LG, PTPRC
10ganglioside4410.6MAG, CD40, CD40LG, CD59, PTPRC
11ivig4410.6MAG, CD40, CD40LG
12ionomycin4410.6PTPRC, CD40LG, CD70, CD40
13neopterin4410.6CD40, CD40LG, ADA
14fludarabine44 1111.6ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
15doxorubicin44 49 1112.5CCND1, CD40, CD40LG, BIRC3, ADA
16paraffin4410.5CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
17genistein44 28 59 2 11 2415.5CCND1, ZAP70, CD40, CD40LG, PTPRC
18cyclosporin a44 28 5912.5CD40, CD40LG, CD59, PTPRC, ADA
19paclitaxel44 49 1112.5ADA, CCND1
20rituximab44 49 1112.5PAX5, ZAP70, MAG, CD40, CD40LG, CD59
21thalidomide44 49 59 1113.5CCND1, CD40LG, BIRC3
22n acetylcysteine4410.5PTPRC, CD40LG, CD40, CCND1
23dexamethasone44 49 28 1113.5ZAP70, CD40, CD40LG, BIRC3, PTPRC, ADA
24phosphatidylinositol4410.4CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
25histamine44 28 2412.4CD40, CD40LG, PTPRC, ADA
26sp 60012544 5911.4BIRC3, CD40, CCND1
27calcium44 49 11 2413.4TNFRSF17, ZAP70, MAG, CD59, BIRC3, MS4A1
28lipid4410.3ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
29biotin44 11 2412.3ADA, CD40LG, CD40
30cysteine4410.3MAG, CD40, CD40LG, CD27, PTPRC, ADA
31tyrosine4410.3CCND1, ZAP70, MAG, CD40, CD59, BIRC3
32tuberculin4410.3CD40LG, ADA
33oligonucleotide4410.2PAX5, BIRC3, CD40, ZAP70, CCND1
34atorvastatin44 49 28 11 2414.0CD59, CD40LG, CD40

GO Terms for genes affiliated with Waldenstrom Macroglobulinemia

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16Gene Ontology
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Cellular components related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.4ZAP70, STOML2
2external side of plasma membraneGO:00989710.2ADA, PTPRC, MS4A1, CD27, CD40LG, CD40
3integral to plasma membraneGO:0058879.8HAS1, CD40, CD70, CD40LG, CD27, MS4A1
4plasma membraneGO:0058869.7MAG, IGHM, ZAP70, HAS1, TNFRSF17, CD40

Biological processes related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.5PTPRC, CD40LG, CD40
2positive regulation of B cell proliferationGO:03089010.5ADA, PTPRC, CD40
3T cell activationGO:04211010.5IRF4, ZAP70, ADA
4regulation of immunoglobulin secretionGO:05102310.4CD40, CD40LG
5positive regulation of alpha-beta T cell differentiationGO:04663810.4ADA, ZAP70
6cell surface receptor signaling pathwayGO:00716610.3PTPRC, BIRC3, CD59, CD27
7positive regulation of endothelial cell apoptotic processGO:200035310.3CD40LG, CD40
8immune responseGO:00695510.3MS4A1, CD70, IGHM, ZAP70
9T cell receptor signaling pathwayGO:05085210.0STOML2, ZAP70, PTPRC

Products for genes affiliated with Waldenstrom Macroglobulinemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Waldenstrom Macroglobulinemia

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26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet