MCID: WLD002
MIFTS: 52

Waldenstrom Macroglobulinemia malady

Immune category

Summaries for Waldenstrom Macroglobulinemia

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. it usually affects older adults and is primarily found in the bone marrow, although lymph nodes and the spleen may be involved. affected individuals have a high level of an antibody called immunoglobulin m (igm) in their blood, which can cause thickening of the blood (hyperviscosity). although some individuals initially do not have symptoms and are diagnosed from routine blood work, common symptoms may include weakness, appetite loss and weight loss. other symptoms may include peripheral neuropathy, fever, raynaud's phenomenon, and mental status changes. hyperviscosity of the blood may cause nosebleeds, headaches, dizziness, and blurring or loss of vision. the cause of the condition is not known but environmental, genetic, and viral factors have been suggested. there have been some reports of familial cases suggesting a genetic predisposition. treatment is often reserved for those with symptoms and may include various medications including corticosteroids, alkylating agents, biologic response modifiers and purine analogues. last updated: 10/1/2013

MalaCards: Waldenstrom Macroglobulinemia, also known as lymphoplasmacytic lymphoma, is related to macroglobulinemia and macroglobulinemia, waldenstrom, somatic. An important gene associated with Waldenstrom Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Primary immunodeficiency and Glial Cell Differentiation. The drugs cyclophosphamide and thalidomide and the compounds 8-chloroadenosine and fluorochrome have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, lymph node and spleen, and related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Waldenstrom Macroglobulinemia

Sources:
43NIH Rare Diseases, 45Novoseek, 31LifeMap Discovery™, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

waldenstrom macroglobulinemia 43 45 31 61
lymphoplasmacytic lymphoma 43 61
waldenstrom's macroglobulinaemia 43
macroglobulinemia of waldenstrom 43
waldenstrom's syndrome 43


Related Diseases for Waldenstrom Macroglobulinemia

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Waldenstrom Macroglobulinemia family:

macroglobulinemia, waldenstrom 2 macroglobulinemia, waldenstrom 1

Diseases related to Waldenstrom Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.8MAG, PAX5
2macroglobulinemia, waldenstrom, somatic30.7ADA, PTPRC, PAX5, MS4A1, BIRC3, CD59
3cryoglobulinemia30.4CD40LG
4lymphoma, diffuse large cell30.2MS4A1, PAX5, PTPRC
5t-cell leukemia30.2IRF4, ZAP70, CD40, BIRC3, PTPRC, ADA
6hepatitis c30.1PAX5, CD40LG, IGHM
7follicular lymphoma30.1IRF4, CCND1, ZAP70, IGHM, CD40, PTPRC
8burkitt's lymphoma30.1ADA, PTPRC, PAX5, MS4A1, BIRC3, CD59
9bone lymphoma10.5
10lymphoplasmacytic lymphoma10.5
11liver lymphoma10.2
12n syndrome10.2
13aplastic anemia10.2
14cold agglutinin disease10.2
15primary malignant lymphoma10.2
16primary bone lymphoma10.2
17polycythemia vera10.2
18central retinal vein occlusion10.2
19protein-losing enteropathy10.2
20poems syndrome10.2
21mantle cell lymphoma10.2
22amyloidosis10.2
23leukemia, t-cell, chronic10.2
24macroglobulinemia, waldenstrom 110.2
25intestinal lymphangiectasia10.2
26neurofibromatosis10.1
27evans' syndrome10.1
28thyroid lymphoma10.1
29wiskott-aldrich syndrome10.1
30peliosis hepatis10.1
31polyarteritis nodosa10.1
32hemoglobinuria10.1
33nocardiosis10.1
34gamma heavy chain disease10.1
35nasal cavity lymphoma10.1
36lung lymphoma10.1
37cerebral lymphoma10.1
38composite lymphoma10.1
39spinal cord lymphoma10.1
40renal tubular acidosis10.1
41diffuse large b-cell lymphoma10.1
42retroperitoneal lymphoma10.1
43splenic marginal zone lymphoma10.1
44hepatitis a10.1
45paroxysmal nocturnal hemoglobinuria10.1
46mastocytosis10.1
47necrobiotic xanthogranuloma10.1
48renal tubular acidosis, distal10.1
49splenomegaly10.1
50lymphoma, somatic10.1

Graphical network of the top 20 diseases related to Waldenstrom Macroglobulinemia:



Diseases related to waldenstrom macroglobulinemia

Clinical Features for Waldenstrom Macroglobulinemia

Drugs & Therapeutics for Waldenstrom Macroglobulinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Waldenstrom Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Waldenstrom Macroglobulinemia

Search NIH Clinical Center for Waldenstrom Macroglobulinemia

Search CenterWatch for Waldenstrom Macroglobulinemia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Waldenstrom Macroglobulinemia cell therapies at LifeMap Discovery.

Genetic Tests for Waldenstrom Macroglobulinemia

Anatomical Context for Waldenstrom Macroglobulinemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Waldenstrom Macroglobulinemia:

33
Spinal cord, Lymph node, Spleen, Bone marrow, Heart, Small intestine, Myeloid, T cells, B lymphoblasts, B cells

Animal Models for Waldenstrom Macroglobulinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Waldenstrom Macroglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CD59, IGHM
2MP:00028739.9CCND1, TNFRSF17, HAS1, ZAP70, IGHM, CD40
3MP:00053909.9CCND1, IGHM, CD40, CD40LG, PAX5, PTPRC
4MP:00053849.7CD40, IGHM, ZAP70, IRF4, CCND1, CD40LG
5MP:00053979.7ADA, CCND1, TNFRSF17, IRF4, ZAP70, IGHM
6MP:00053879.6IGHM, ZAP70, STOML2, IRF4, TNFRSF17, CCND1

Publications for Waldenstrom Macroglobulinemia

Sources:
51PubMed
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Articles related to Waldenstrom Macroglobulinemia:

(show top 50)    (show all 230)
idTitleAuthorsYear
1
Fludarabine in Waldenstrom's macroglobulinemia. (23782076)
2013
2
Waldenstrom's macroglobulinemia presenting with lytic bone lesions: a rare presentation. (24086947)
2013
3
Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia. (24335105)
2013
4
Waldenstrom's macroglobulinemia associated with eosinophilia. (23589787)
2013
5
The Case a8L Hyperbicarbonatemia in a patient with Waldenstrom's macroglobulinemia. Pseudohyperbicarbonatemia due to paraproteinemia. (22373713)
2012
6
Fludarabine plus cyclophosphamide and rituximab in Waldenstrom macroglobulinemia: an effective but myelosuppressive regimen to be offered to patients with advanced disease. (21732338)
2012
7
Concomitant Waldenstrom macroglobulinemia and IgA plasmablastic myeloma in a patient with untreated IgM paraproteinemia: sequential development of biclonal B-cell neoplasms over a 10-year period in a single individual. (22404949)
2012
8
A multicenter phase II study of single-agent enzastaurin in previously treated Waldenstrom macroglobulinemia. (22879385)
2012
9
Progression in smoldering Waldenstrom macroglobulinemia: long-term results. (22451426)
2012
10
Are you sure this is Waldenstrom macroglobulinemia? (23233639)
2012
11
Serum galactomannan and (1->3)-I^-D-glucan assays for patients with multiple myeloma and Waldenstrom's macroglobulinemia. (22170932)
2012
12
Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy. (21350089)
2011
13
The role of serum immunoglobulin free light chain in response and progression in waldenstrom macroglobulinemia. (21415221)
2011
14
Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenstrom macroglobulinemia. (21220746)
2011
15
Successful treatment of eosinophilic colitis by montelukast sodium plus budesonide in a patient with Waldenstrom macroglobulinemia. (21575902)
2011
16
New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia. (21519243)
2011
17
Therapy-Related Myeloid Neoplasms in Chronic Lymphocytic Leukemia and Waldenstrom's Macroglobulinemia. (21869917)
2011
18
Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1. (21415268)
2011
19
Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity. (21921047)
2011
20
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
21
High-dose therapy and autologous stem-cell transplantation in Waldenstrom macroglobulinemia: the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. (20368570)
2010
22
Waldenstrom's macroglobulinemia: Recent advances in biology and therapy. (20040909)
2009
23
Bortezomib and Waldenstrom's macroglobulinemia. (19351237)
2009
24
MicroRNAs to know in Waldenstrom macroglobulinemia. (19406998)
2009
25
SDF1/CXCL12 (-801GA) polymorphism is a prognostic factor after treatment initiation in Waldenstrom macroglobulinemia. (19394082)
2009
26
Lymphoplasmacytic lymphoma-Waldenstrom's macroglobulinemia. (18499469)
2008
27
Effect of plasmapheresis on hyperviscosity-related retinopathy and retinal hemodynamics in patients with Waldenstrom's macroglobulinemia. (18326744)
2008
28
Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia. (18452095)
2008
29
Phenotypic evolution of Waldenstrom's macroglobulinemia to extramedullary plasmacytoma. (18467735)
2008
30
Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia. (17632262)
2007
31
Bortezomib is active in patients with untreated or relapsed Waldenstrom's macroglobulinemia: a phase II study of the National Cancer Institute of Canada Clinical Trials Group. (17353550)
2007
32
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. (17761832)
2007
33
Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom's macroglobulinemia: results of WMCTG Trial 03-248. (17545538)
2007
34
IgM-expressing Waldenstrom's macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo. (17287856)
2007
35
Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. (16788002)
2006
36
'Indolent' Waldenstrom's macroglobulinemia and a cerebrospinal fluid protein level of 16 g/L. (16827886)
2006
37
Fanconi's syndrome induced by a monoclonal Vkappa3 light chain in Waldenstrom's macroglobulinemia. (15806478)
2005
38
CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia. (15794857)
2005
39
Diagnosis and management of Waldenstrom's macroglobulinemia. (15735132)
2005
40
Metronomic chemoimmunotherapy in a patient with refractory Waldenstrom's macroglobulinemia. (16334910)
2005
41
Differential diagnosis of Waldenstrom's macroglobulinemia and other B-cell disorders. (15794855)
2005
42
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
43
Clinical responses to sildenafil in Waldenstrom's macroglobulinemia. (15636699)
2004
44
Waldenstrom's macroglobulinemia presenting as new-onset ascites. (15464256)
2004
45
Clinical features of Waldenstrom macroglobulinemia in Korea. (15481603)
2004
46
Potential new therapeutics for Waldenstrom's macroglobulinemia. (12720152)
2003
47
Uniform response criteria in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. (12720121)
2003
48
Gastric involvement in Waldenstrom macroglobulinemia: CT findings. (9233876)
1997
49
Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma. (8204889)
1994
50
Waldenstrom macroglobulinemia. (13698157)
1961

Genetic Variations for Waldenstrom Macroglobulinemia

Expression for genes affiliated with Waldenstrom Macroglobulinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Waldenstrom Macroglobulinemia

Search GEO for disease gene expression data for Waldenstrom Macroglobulinemia.

Pathways for genes affiliated with Waldenstrom Macroglobulinemia

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 12EMD Millipore, 52QIAGEN, 56SinoBiological
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Pathways related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ADA, ZAP70
210.3MIR206, MAG
310.3ZAP70, CD40, CD40LG
4
Hide members
10.3CD40, CD40LG, CD59
510.3CD40, CD40LG, PTPRC
610.3BIRC3, CD40LG, CD40
7
Hide members
10.3IRF4, ZAP70, CD40LG, PTPRC
810.3ZAP70, CD40, CD40LG, BIRC3
9
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.3BIRC3, CD27, CD70
1010.3MAG, CD40, CD40LG, PTPRC
11
Hide members
10.2CD40LG, CD40, TNFRSF17, CCND1
12
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
10.2TNFRSF17, CD40, CD40LG, BIRC3
1310.2ADA, PAX5, BIRC3, CCND1
14
Hide members
10.2CD27, CD40LG, CD70, CD40, TNFRSF17
15
Hide members
10.1IRF4, ZAP70, IGHM, CD40, CD40LG, CD59
16
Hide members
10.1TNFRSF17, CD40, CD70, CD40LG, CD27, BIRC3

Compounds for genes affiliated with Waldenstrom Macroglobulinemia

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
18-chloroadenosine4510.7CCND1, ADA
2fluorochrome4510.7PTPRC, CD40LG, ZAP70
3blys4510.7CD40LG, CD40, TNFRSF17
4bcma4510.7CD27, CD40, TNFRSF17
5fitc4510.7PTPRC, CD59, ZAP70
6serine4510.7CCND1, MAG, BIRC3
7hyaluronic acid45 2411.6PTPRC, CD40LG, CD40, HAS1
8cytidine45 11 2412.6ZAP70, CD40, CD40LG, PAX5, ADA
9formaldehyde45 2411.6CCND1, ZAP70, CD40LG, PTPRC
10ganglioside4510.6MAG, CD40, CD40LG, CD59, PTPRC
11ivig4510.6MAG, CD40, CD40LG
12ionomycin4510.6PTPRC, CD40LG, CD70, CD40
13neopterin4510.6CD40, CD40LG, ADA
14fludarabine45 1111.6ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
15doxorubicin45 50 1112.5CCND1, CD40, CD40LG, BIRC3, ADA
16paraffin4510.5CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
17genistein45 29 60 2 11 2415.5CCND1, ZAP70, CD40, CD40LG, PTPRC
18cyclosporin a45 29 6012.5CD40, CD40LG, CD59, PTPRC, ADA
19paclitaxel45 50 1112.5ADA, CCND1
20rituximab45 50 1112.5PAX5, ZAP70, MAG, CD40, CD40LG, CD59
21thalidomide45 50 60 1113.5CCND1, CD40LG, BIRC3
22n acetylcysteine4510.5PTPRC, CD40LG, CD40, CCND1
23dexamethasone45 50 29 1113.5ZAP70, CD40, CD40LG, BIRC3, PTPRC, ADA
24phosphatidylinositol4510.4CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
25histamine45 29 2412.4CD40, CD40LG, PTPRC, ADA
26sp 60012545 6011.4BIRC3, CD40, CCND1
27calcium45 50 11 2413.4TNFRSF17, ZAP70, MAG, CD59, BIRC3, MS4A1
28lipid4510.3ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
29biotin45 11 2412.3ADA, CD40LG, CD40
30cysteine4510.3MAG, CD40, CD40LG, CD27, PTPRC, ADA
31tyrosine4510.3CCND1, ZAP70, MAG, CD40, CD59, BIRC3
32tuberculin4510.3CD40LG, ADA
33oligonucleotide4510.2PAX5, BIRC3, CD40, ZAP70, CCND1
34atorvastatin45 50 29 11 2414.0CD59, CD40LG, CD40

GO Terms for genes affiliated with Waldenstrom Macroglobulinemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.4ZAP70, STOML2
2external side of plasma membraneGO:00989710.2ADA, PTPRC, MS4A1, CD27, CD40LG, CD40
3integral to plasma membraneGO:0058879.8HAS1, CD40, CD70, CD40LG, CD27, MS4A1
4plasma membraneGO:0058869.7MAG, IGHM, ZAP70, HAS1, TNFRSF17, CD40

Biological processes related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.5PTPRC, CD40LG, CD40
2positive regulation of B cell proliferationGO:03089010.5ADA, PTPRC, CD40
3T cell activationGO:04211010.5IRF4, ZAP70, ADA
4regulation of immunoglobulin secretionGO:05102310.4CD40, CD40LG
5positive regulation of alpha-beta T cell differentiationGO:04663810.4ADA, ZAP70
6cell surface receptor signaling pathwayGO:00716610.3PTPRC, BIRC3, CD59, CD27
7positive regulation of endothelial cell apoptotic processGO:200035310.3CD40LG, CD40
8immune responseGO:00695510.3MS4A1, CD70, IGHM, ZAP70
9T cell receptor signaling pathwayGO:05085210.0STOML2, ZAP70, PTPRC

Products for genes affiliated with Waldenstrom Macroglobulinemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Waldenstrom Macroglobulinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet