MCID: WLD002
MIFTS: 44

Waldenstrom Macroglobulinemia malady

Immune diseases category

Summaries for Waldenstrom Macroglobulinemia

About this section
Sources:
42NIH Rare Diseases, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. it usually affects older adults and is primarily found in the bone marrow, although lymph nodes and the spleen may be involved. affected individuals have a high level of an antibody called immunoglobulin m (igm) in their blood, which can cause thickening of the blood (hyperviscosity). although some individuals initially do not have symptoms and are diagnosed from routine blood work, common symptoms may include weakness, appetite loss and weight loss. other symptoms may include peripheral neuropathy, fever, raynaud's phenomenon, and mental status changes. hyperviscosity of the blood may cause nosebleeds, headaches, dizziness, and blurring or loss of vision. the cause of the condition is not known but environmental, genetic, and viral factors have been suggested. there have been some reports of familial cases suggesting a genetic predisposition. treatment is often reserved for those with symptoms and may include various medications including corticosteroids, alkylating agents, biologic response modifiers and purine analogues. last updated: 10/1/2013

MalaCards: Waldenstrom Macroglobulinemia, also known as lymphoplasmacytic lymphoma, is related to macroglobulinemia and myeloma. An important gene associated with Waldenstrom Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Primary immunodeficiency and Glial Cell Differentiation. The drugs cyclophosphamide and thalidomide and the compounds 8-chloroadenosine and fluorochrome have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lymph node, and related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Waldenstrom Macroglobulinemia

About this section
Sources:
42NIH Rare Diseases, 44Novoseek, 30LifeMap Discovery™, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

waldenstrom macroglobulinemia 42 44 30 60
lymphoplasmacytic lymphoma 42 60
waldenstrom's macroglobulinaemia 42
macroglobulinemia of waldenstrom 42
waldenstrom's syndrome 42


Related Diseases for Waldenstrom Macroglobulinemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Waldenstrom Macroglobulinemia family:

Macroglobulinemia, Waldenstrom 2 Macroglobulinemia, Waldenstrom 1

Diseases related to Waldenstrom Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.7MAG, PAX5
2myeloma30.7PTPRC, PAX5, BIRC3, CD27, CD40LG, CD40
3multiple myeloma30.6CD40, IRF4, CCND1
4macroglobulinemia, waldenstrom, somatic30.5PAX5, PTPRC, ADA, MS4A1, BIRC3, CD40
5leukemia30.4PAX5, BIRC3, IRF4, CD40LG, CD40, ZAP70
6cryoglobulinemia30.4CD40LG
7hepatitis c30.3IGHM, CD40LG, PAX5
8non-hodgkin lymphoma30.3ADA, PTPRC, PAX5, MS4A1, BIRC3, CD59
9hepatitis30.2CD40LG
10hairy cell leukemia30.2CCND1, CD40, PTPRC, ADA
11hematologic cancer30.2ZAP70, PAX5, ADA
12chronic lymphocytic leukemia30.2CCND1, TNFRSF17, ZAP70, IGHM, CD40, CD70
13bone lymphoma10.5
14lymphoplasmacytic lymphoma10.4
15histiocytosis10.3
16liver lymphoma10.2
17aplastic anemia10.2
18polycythemia vera10.1
19central retinal vein occlusion10.1
20protein-losing enteropathy10.1
21poems syndrome10.1
22mantle cell lymphoma10.1
23diffuse large b-cell lymphoma10.1
24amyloidosis10.1
25hypertension10.1
26neuropathy10.1
27pancreatitis10.1
28polycythemia10.1
29retinal vein occlusion10.1
30retinitis10.1
31neurofibromatosis10.0
32ureteral obstruction10.0
33evans' syndrome10.0
34thyroid lymphoma10.0
35cerebritis10.0
36wiskott-aldrich syndrome10.0
37peliosis hepatis10.0
38polyarteritis nodosa10.0
39hemoglobinuria10.0
40nocardiosis10.0
41gamma heavy chain disease10.0
42nasal cavity lymphoma10.0
43lung lymphoma10.0
44cerebral lymphoma10.0
45composite lymphoma10.0
46ureteral lymphoma10.0
47spinal cord lymphoma10.0
48renal tubular acidosis10.0
49retroperitoneal lymphoma10.0
50splenic marginal zone lymphoma10.0

Graphical network of the top 20 diseases related to Waldenstrom Macroglobulinemia:



Diseases related to waldenstrom macroglobulinemia

Clinical Features for Waldenstrom Macroglobulinemia

About this section

Drugs & Therapeutics for Waldenstrom Macroglobulinemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Waldenstrom Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Waldenstrom Macroglobulinemia

Search NIH Clinical Center for Waldenstrom Macroglobulinemia

Search CenterWatch for Waldenstrom Macroglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Waldenstrom Macroglobulinemia cell therapies at LifeMap Discovery.

Genetic Tests for Waldenstrom Macroglobulinemia

About this section

Anatomical Context for Waldenstrom Macroglobulinemia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Waldenstrom Macroglobulinemia:

32
Bone, Bone marrow, Lymph node, Spleen

Animal Models for Waldenstrom Macroglobulinemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Waldenstrom Macroglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CD59, IGHM
2MP:00028739.9TNFRSF17, HAS1, ZAP70, IGHM, BIRC3, PAX5
3MP:00053909.9PAX5, CD40LG, CD40, IGHM, CCND1, PTPRC
4MP:00053849.7IGHM, PTPRC, ADA, PAX5, MS4A1, BIRC3
5MP:00053979.7CD59, CD40LG, CD70, CD40, IGHM, ZAP70
6MP:00053879.6CCND1, CD40LG, CD70, CD40, IGHM, ZAP70

Publications for Waldenstrom Macroglobulinemia

About this section

Genetic Variations for Waldenstrom Macroglobulinemia

About this section

Expression for genes affiliated with Waldenstrom Macroglobulinemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Waldenstrom Macroglobulinemia

Search GEO for disease gene expression data for Waldenstrom Macroglobulinemia.

Pathways for genes affiliated with Waldenstrom Macroglobulinemia

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 55SinoBiological
See all sources

Pathways related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ADA, ZAP70
210.3MIR206, MAG
310.3ZAP70, CD40, CD40LG
4
Hide members
10.3CD40, CD40LG, CD59
510.3CD40, CD40LG, PTPRC
610.3BIRC3, CD40LG, CD40
7
Hide members
10.3IRF4, ZAP70, CD40LG, PTPRC
810.3ZAP70, CD40, CD40LG, BIRC3
9
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.3BIRC3, CD27, CD70
1010.3MAG, CD40, CD40LG, PTPRC
11
Hide members
10.2CD40LG, CD40, TNFRSF17, CCND1
12
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
10.2TNFRSF17, CD40, CD40LG, BIRC3
1310.2ADA, PAX5, BIRC3, CCND1
14
Hide members
10.2CD27, CD40LG, CD70, CD40, TNFRSF17
15
Hide members
10.1IRF4, ZAP70, IGHM, CD40, CD40LG, CD59
16
Hide members
10.1TNFRSF17, CD40, CD70, CD40LG, CD27, BIRC3

Compounds for genes affiliated with Waldenstrom Macroglobulinemia

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
18-chloroadenosine4410.7CCND1, ADA
2fluorochrome4410.7PTPRC, CD40LG, ZAP70
3blys4410.7CD40LG, CD40, TNFRSF17
4bcma4410.7CD27, CD40, TNFRSF17
5fitc4410.7PTPRC, CD59, ZAP70
6serine4410.7CCND1, MAG, BIRC3
7hyaluronic acid44 2411.6PTPRC, CD40LG, CD40, HAS1
8cytidine44 11 2412.6ZAP70, CD40, CD40LG, PAX5, ADA
9formaldehyde44 2411.6CCND1, ZAP70, CD40LG, PTPRC
10ganglioside4410.6MAG, CD40, CD40LG, CD59, PTPRC
11ivig4410.6MAG, CD40, CD40LG
12ionomycin4410.6PTPRC, CD40LG, CD70, CD40
13neopterin4410.6CD40, CD40LG, ADA
14fludarabine44 1111.6ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
15doxorubicin44 49 1112.5CCND1, CD40, CD40LG, BIRC3, ADA
16paraffin4410.5CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
17genistein44 28 59 2 11 2415.5CCND1, ZAP70, CD40, CD40LG, PTPRC
18cyclosporin a44 28 5912.5CD40, CD40LG, CD59, PTPRC, ADA
19paclitaxel44 49 1112.5ADA, CCND1
20rituximab44 49 1112.5PAX5, ZAP70, MAG, CD40, CD40LG, CD59
21thalidomide44 49 59 1113.5CCND1, CD40LG, BIRC3
22n acetylcysteine4410.5PTPRC, CD40LG, CD40, CCND1
23dexamethasone44 49 28 1113.5ZAP70, CD40, CD40LG, BIRC3, PTPRC, ADA
24phosphatidylinositol4410.4CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
25histamine44 28 2412.4CD40, CD40LG, PTPRC, ADA
26sp 60012544 5911.4BIRC3, CD40, CCND1
27calcium44 49 11 2413.4TNFRSF17, ZAP70, MAG, CD59, BIRC3, MS4A1
28lipid4410.3ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
29biotin44 11 2412.3ADA, CD40LG, CD40
30cysteine4410.3MAG, CD40, CD40LG, CD27, PTPRC, ADA
31tyrosine4410.3CCND1, ZAP70, MAG, CD40, CD59, BIRC3
32tuberculin4410.3CD40LG, ADA
33oligonucleotide4410.2PAX5, BIRC3, CD40, ZAP70, CCND1
34atorvastatin44 49 28 11 2414.0CD59, CD40LG, CD40

GO Terms for genes affiliated with Waldenstrom Macroglobulinemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.4ZAP70, STOML2
2external side of plasma membraneGO:00989710.2ADA, PTPRC, MS4A1, CD27, CD40LG, CD40
3integral to plasma membraneGO:0058879.8HAS1, CD40, CD70, CD40LG, CD27, MS4A1
4plasma membraneGO:0058869.7TNFRSF17, HAS1, ZAP70, IGHM, MAG, CD40

Biological processes related to Waldenstrom Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.5CD40, CD40LG, PTPRC
2positive regulation of B cell proliferationGO:03089010.5CD40, PTPRC, ADA
3T cell activationGO:04211010.5IRF4, ZAP70, ADA
4regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
5positive regulation of endothelial cell apoptotic processGO:200035310.4CD40LG, CD40
6cell surface receptor signaling pathwayGO:00716610.3CD59, PTPRC, BIRC3, CD27
7positive regulation of alpha-beta T cell differentiationGO:04663810.3ZAP70, ADA
8immune responseGO:00695510.3ZAP70, IGHM, CD70, MS4A1
9T cell receptor signaling pathwayGO:05085210.0PTPRC, ZAP70, STOML2

Products for genes affiliated with Waldenstrom Macroglobulinemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Waldenstrom Macroglobulinemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet