MCID: WLD003
MIFTS: 27

Waldmann Disease malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Gastrointestinal diseases, Immune diseases categories

Summaries for Waldmann Disease

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NIH Rare Diseases:43 Waldmann disease is a digestive disorder characterized abnormally enlarged lymph vessels supplying the lining of the small intestine.  the cause of waldmann disease is unknown. signs of waldmann disease include loss of lymphatic fluid into the gastrointestinal tract, protein-losing enteropathy, too little albumin in the blood, reduced levels of antibodies, and immunodeficiency. symptoms include swelling in the legs and abdominal discomfort. for many patients, treatment of waldmann disease involves long term diet therapy. last updated: 1/9/2014

MalaCards based summary: Waldmann Disease, also known as primary intestinal lymphangiectasia, is related to osteomalacia and lymphangiectasis, and has symptoms including lymphopenia, hypoproteinemia and hypogammaglobulinemia. Affiliated tissues include small intestine, skin and bone.

Wikipedia:65 Waldmann disease, also known as Waldmann\'s disease and Primary intestinal lymphangiectasia, is a rare... more...

Aliases & Classifications for Waldmann Disease

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Waldmann Disease, Aliases & Descriptions:

Name: Waldmann Disease 43 49 62
Primary Intestinal Lymphangiectasia 43 49
Primary Intestinal Lymphangiectasis 43 62
 
Familial Waldmann's Disease 43 62
Waldmann's Disease 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
waldmann disease:
Age of onset: All ages; Age of death: any age


External Ids:

Orphanet49 90362
MESH via Orphanet36 C536567
ICD10 via Orphanet28 I89.0
UMLS via Orphanet63 C0267372, C2931241

Related Diseases for Waldmann Disease

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Diseases related to Waldmann Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1osteomalacia10.4
2lymphangiectasis10.4
3b-cell lymphomas10.4
4osteoporosis10.2
5diffuse large b-cell lymphoma10.2
6protein-losing enteropathy10.2
7adenocarcinoma10.2
8lymphangioma10.2
9nephrotic syndrome10.2

Graphical network of diseases related to Waldmann Disease:



Diseases related to waldmann disease

Symptoms for Waldmann Disease

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Symptoms:

 49 (show all 28)
  • edema of the legs/lower limbs
  • anomalies of the lymphatic system
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency
  • lymphopenia
  • hypoproteinemia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • malabsorption/chronic diarrhea/steatorrhea
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • thick skin/pachydermia/orange skin
  • warts/papillomas
  • ascitis
  • intestinal obstruction/ileus
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • gangrena/necrosis
  • vaginal hydrocele/hematocele/pyocele/lymphocele/varicocele
  • meningitis/meningeal syndrome
  • seizures/epilepsy/absences/spasms/status epilepticus
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • ferropenic anemia
  • hypocalcemia
  • lymphoma
  • hydrops fetalis

HPO human phenotypes related to Waldmann Disease:

(show all 24)
id Description Frequency HPO Source Accession
1 lymphopenia hallmark (90%) HP:0001888
2 hypoproteinemia hallmark (90%) HP:0003075
3 hypogammaglobulinemia hallmark (90%) HP:0004313
4 edema of the lower limbs hallmark (90%) HP:0010741
5 abnormality of the lymphatic system hallmark (90%) HP:0100763
6 weight loss typical (50%) HP:0001824
7 nausea and vomiting typical (50%) HP:0002017
8 malabsorption typical (50%) HP:0002024
9 abdominal pain typical (50%) HP:0002027
10 thickened skin occasional (7.5%) HP:0001072
11 seizures occasional (7.5%) HP:0001250
12 meningitis occasional (7.5%) HP:0001287
13 ascites occasional (7.5%) HP:0001541
14 abnormality of the pericardium occasional (7.5%) HP:0001697
15 hydrops fetalis occasional (7.5%) HP:0001789
16 iron deficiency anemia occasional (7.5%) HP:0001891
17 abnormality of the pleura occasional (7.5%) HP:0002103
18 lymphoma occasional (7.5%) HP:0002665
19 hypocalcemia occasional (7.5%) HP:0002901
20 reduced bone mineral density occasional (7.5%) HP:0004349
21 intestinal obstruction occasional (7.5%) HP:0005214
22 vaginal hernia occasional (7.5%) HP:0100672
23 gangrene occasional (7.5%) HP:0100758
24 verrucae occasional (7.5%) HP:0200043

Drugs & Therapeutics for Waldmann Disease

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Drug clinical trials:

Search ClinicalTrials for Waldmann Disease

Search NIH Clinical Center for Waldmann Disease

Genetic Tests for Waldmann Disease

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Anatomical Context for Waldmann Disease

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MalaCards organs/tissues related to Waldmann Disease:

33
Small intestine, Skin, Bone, B cells

Animal Models for Waldmann Disease or affiliated genes

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Publications for Waldmann Disease

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Articles related to Waldmann Disease:

idTitleAuthorsYear
1
Pregnancy and Waldmann disease. (18594747)
2008

Variations for Waldmann Disease

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Expression for genes affiliated with Waldmann Disease

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Search GEO for disease gene expression data for Waldmann Disease.

Pathways for genes affiliated with Waldmann Disease

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Compounds for genes affiliated with Waldmann Disease

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GO Terms for genes affiliated with Waldmann Disease

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Products for genes affiliated with Waldmann Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Waldmann Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet