MCID: WLL004
MIFTS: 36

Wallerian Degeneration malady

Categories: Rare diseases

Aliases & Classifications for Wallerian Degeneration

Aliases & Descriptions for Wallerian Degeneration:

Name: Wallerian Degeneration 50 52 69
Wallerian Degeneration of the Pyramidal Tract 50

Classifications:



Summaries for Wallerian Degeneration

MalaCards based summary : Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to neuronitis and cerebritis. An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Choline and Cytidine Diphosphate Choline have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and monocytes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

Wikipedia : 71 Wallerian degeneration is a process that results when a nerve fiber is cut or crushed and the part of... more...

Related Diseases for Wallerian Degeneration

Diseases related to Wallerian Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 neuronitis 10.3
2 cerebritis 10.2
3 cervicitis 10.2
4 spinal cord injury 10.2
5 hepatopulmonary syndrome 10.2 SEMA3A VEGFA
6 neuropathy 10.1
7 ischemia 10.0
8 retinitis 10.0
9 brain injury 10.0
10 dilated cardiomyopathy 9.9 CNTF MPZ VEGFA
11 white piedra 9.9 MAG MPZ VEGFA
12 relapsing-remitting multiple sclerosis 9.9
13 hypoxia 9.9
14 middle cerebral artery infarction 9.9
15 pulmonary hemosiderosis 9.9 CNTF MAG MPZ
16 thrombosis 9.7
17 leukodystrophy 9.7
18 myocarditis 9.7
19 tooth disease 9.7
20 hemiplegia 9.7
21 encephalitis 9.7
22 mononeuropathy 9.7
23 cerebral hypoxia 9.7
24 alexia 9.7
25 dysautonomia 9.7
26 hyperprolactinemia 9.7
27 neuritis 9.7
28 encephalopathy 9.7
29 head injury 9.7
30 charcot-marie-tooth disease 9.7
31 endotheliitis 9.7
32 retinal ischemia 9.7
33 acute sensory ataxic neuropathy 9.7
34 colchicine poisoning 9.7
35 spinal muscular atrophy 9.7
36 progressive multifocal leukoencephalopathy 9.7
37 traumatic brain injury 9.7
38 prion disease 9.7
39 lymphoma 9.7
40 cerebrovascular disease 9.7
41 agraphia 9.7
42 muscular atrophy 9.7
43 wegmann jones smith syndrome 7.8 CLU CNTF ERBB2 MAG MPZ NEFM

Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to Wallerian Degeneration

Symptoms & Phenotypes for Wallerian Degeneration

GenomeRNAi Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.53 UBE4B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.53 CNTF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.53 SEMA3A UBE4B CNTF ERBB2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.53 CNTF
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.53 UBE4B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.53 CNTF
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.53 SEMA3A CNTF
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.53 SEMA3A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.53 SEMA3A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.53 ERBB2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.53 ERBB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.53 CNTF
13 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 SEMA3A SEMA3F VEGFA ERBB2 NRP2

MGI Mouse Phenotypes related to Wallerian Degeneration:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CLU SEMA3A CNTF SEMA3F ERBB2 UBE4B
2 cellular MP:0005384 9.9 NRP2 ODC1 SARM1 SEMA3A CNTF SEMA3F
3 muscle MP:0005369 9.5 NRP2 CLU CNTF ERBB2 UBE4B VEGFA
4 nervous system MP:0003631 9.47 SARM1 CLU SEMA3A CNTF SEMA3F ERBB2

Drugs & Therapeutics for Wallerian Degeneration

Drugs for Wallerian Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Choline Approved, Nutraceutical Phase 4 62-49-7 305
2 Cytidine Diphosphate Choline Phase 4
3 Nootropic Agents Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03046693 Phase 4
2 Focal Cortical Atrophy After Myocardial Internal Capsule Completed NCT01862172

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

Anatomical Context for Wallerian Degeneration

MalaCards organs/tissues related to Wallerian Degeneration:

39
Spinal Cord, Brain, Monocytes, Cortex, Bone, Bone Marrow, Pons

Publications for Wallerian Degeneration

Articles related to Wallerian Degeneration:

(show top 50) (show all 527)
id Title Authors Year
1
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. ( 28053206 )
2017
2
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2. ( 27732853 )
2016
3
MRI findings in a case of spinal cord Wallerian degeneration following trauma. ( 27744468 )
2016
4
Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration. ( 27999531 )
2016
5
Molecular mechanisms in the initiation phase of Wallerian degeneration. ( 27062141 )
2016
6
Neurographic course of Wallerian Degeneration after human peripheral nerve injury. ( 27875622 )
2016
7
Avian axons undergo Wallerian degeneration after injury and stress. ( 27614771 )
2016
8
Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance. ( 27073362 )
2016
9
Wallerian Degeneration in the Corticospinal Tract Following Tumefactive Demyelination: Conventional and Advanced Magnetic Resonance Imaging. ( 27417915 )
2016
10
Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination. ( 26712109 )
2016
11
Prolonged Wallerian degeneration in the corticospinal tract following external capsular hemorrhage. ( 27206896 )
2016
12
SYSTEMIC TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELLS PROMOTES AXONAL REGENERATION AND ANALGESIA IN A MODEL OF WALLERIAN DEGENERATION. ( 27607534 )
2016
13
Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings. ( 28072502 )
2016
14
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury. ( 27771719 )
2016
15
Bilateral Wallerian Degeneration of the Pontocerebellar Tracts. ( 26171260 )
2015
16
Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria. ( 26686637 )
2015
17
TGF-I^1 is critical for Wallerian degeneration after rat sciatic nerve injury. ( 25451291 )
2015
18
Wallerian degeneration of the pontocerebellar fibres secondary to pontine infarction. ( 26712359 )
2015
19
Wallerian degeneration of the bilateral middle cerebellar peduncles. ( 25586535 )
2015
20
Longitudinal three-dimensional-T2WI-SPACE study on wallerian degeneration in cat corticospinal tract and underlying pathology changes. ( 26218829 )
2015
21
Wallerian Degeneration of the Superior Cerebellar Peduncle. ( 26457633 )
2015
22
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. ( 26419777 )
2015
23
Early Wallerian degeneration in a neonate with middle carotid artery stroke. ( 25443582 )
2015
24
Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration. ( 25206781 )
2014
25
Decline of compound muscle action potentials and statistical MUNEs during Wallerian degeneration. ( 25240559 )
2014
26
Wallerian degeneration: an emerging axon death pathway linking injury and disease. ( 24840802 )
2014
27
Wallerian degeneration in the optic nerve stretch-injury model of TBI: a stereological analysis. ( 25333317 )
2014
28
Early corticospinal tract Wallerian degeneration versus mesencephalic substantia nigra degeneration secondary to striatal stroke. ( 24468328 )
2014
29
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. ( 24252177 )
2014
30
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
31
Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. ( 25046157 )
2014
32
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. ( 25657736 )
2014
33
Signaling mechanisms regulating Wallerian degeneration. ( 24907513 )
2014
34
Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. ( 24895229 )
2014
35
Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons. ( 24285879 )
2013
36
Excitotoxicity and Wallerian degeneration as a processes related to cell death in nervous system. ( 24442984 )
2013
37
Protective role of Wallerian degeneration slow (Wld(s)) gene against retinal ganglion cell body damage in a Wallerian degeneration model. ( 23403739 )
2013
38
MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling. ( 24124570 )
2013
39
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria. ( 23314018 )
2013
40
Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat. ( 23700281 )
2013
41
Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke. ( 23171053 )
2013
42
Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degeneration. ( 23194661 )
2013
43
protein expression profiling during wallerian degeneration after rat sciatic nerve injury. ( 24123051 )
2013
44
Similarities between inherited demyelinating neuropathies and Wallerian degeneration: an old repair program may cause myelin and axon perturbation under nonlesion conditions. ( 23831295 )
2013
45
Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury. ( 23328443 )
2013
46
Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve. ( 23406314 )
2013
47
Hyperintense signal in pyramidal tract neurons in postoperative brain tumor: wallerian degeneration or neoplastic dissemination? ( 24394880 )
2013
48
The acute phase of Wallerian degeneration: longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery. ( 23396161 )
2013
49
The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI). ( 23543618 )
2013
50
Natural history and prognostic value of corticospinal tract Wallerian degeneration in intracerebral hemorrhage. ( 23913508 )
2013

Variations for Wallerian Degeneration

Expression for Wallerian Degeneration

Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for Wallerian Degeneration

Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.77 CLU MAG NEFM NRP2
2 10.7 CNTF NEFM VEGFA

GO Terms for Wallerian Degeneration

Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.02 CNTF NEFM NRP2 SARM1 SEMA3A
2 neurofibrillary tangle GO:0097418 8.96 CLU NEFM

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.94 CLU CNTF ERBB2 VEGFA
2 negative chemotaxis GO:0050919 9.67 NRP2 SEMA3A SEMA3F
3 semaphorin-plexin signaling pathway GO:0071526 9.65 NRP2 SEMA3A
4 motor neuron axon guidance GO:0008045 9.64 ERBB2 SEMA3A
5 regulation of neuron death GO:1901214 9.63 CLU SARM1
6 negative regulation of axon extension GO:0030517 9.63 MAG SEMA3A
7 nerve development GO:0021675 9.63 NRP2 SEMA3A SEMA3F
8 NAD metabolic process GO:0019674 9.62 NMNAT1 NMNAT2
9 NAD biosynthetic process GO:0009435 9.62 NMNAT1 NMNAT2
10 growth GO:0040007 9.61 CNTF VEGFA
11 pyridine nucleotide biosynthetic process GO:0019363 9.61 NMNAT1 NMNAT2
12 facial nerve structural organization GO:0021612 9.61 NRP2 SEMA3A SEMA3F
13 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.6 MAG MPZ
14 negative regulation of axon extension involved in axon guidance GO:0048843 9.59 SEMA3A SEMA3F
15 branchiomotor neuron axon guidance GO:0021785 9.58 SEMA3A SEMA3F
16 axonogenesis involved in innervation GO:0060385 9.58 NPTX1 SEMA3A
17 sympathetic ganglion development GO:0061549 9.58 NRP2 SEMA3A SEMA3F
18 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.57 SEMA3A SEMA3F
19 trigeminal ganglion development GO:0061551 9.56 NRP2 SEMA3A
20 trigeminal nerve structural organization GO:0021637 9.55 SEMA3A SEMA3F
21 de novo NAD biosynthetic process from aspartate GO:0034628 9.54 NMNAT1 NMNAT2
22 axon extension involved in axon guidance GO:0048846 9.54 NRP2 SEMA3A SEMA3F
23 facioacoustic ganglion development GO:1903375 9.52 NRP2 SEMA3A
24 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.51 NRP2 SEMA3A
25 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.5 NRP2 SEMA3A SEMA3F
26 ventral trunk neural crest cell migration GO:0036486 9.43 NRP2 SEMA3A SEMA3F
27 sympathetic neuron projection extension GO:0097490 9.33 NRP2 SEMA3A SEMA3F
28 sympathetic neuron projection guidance GO:0097491 9.13 NRP2 SEMA3A SEMA3F
29 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 8.8 NRP2 SEMA3A SEMA3F
30 nervous system development GO:0007399 10.02 CNTF ERBB2 MAG NRP2 SARM1 SEMA3A

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemorepellent activity GO:0045499 9.16 SEMA3A SEMA3F
2 nicotinate-nucleotide adenylyltransferase activity GO:0004515 8.96 NMNAT1 NMNAT2
3 nicotinamide-nucleotide adenylyltransferase activity GO:0000309 8.62 NMNAT1 NMNAT2

Sources for Wallerian Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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