MCID: WLL004
MIFTS: 36

Wallerian Degeneration malady

Category: Rare diseases

Aliases & Classifications for Wallerian Degeneration

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Aliases & Descriptions for Wallerian Degeneration:

Name: Wallerian Degeneration 48 50 68
 
Wallerian Degeneration of the Pyramidal Tract 48

Classifications:



Summaries for Wallerian Degeneration

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Wikipedia:71 Wallerian degeneration is a process that results when a nerve fiber is cut or crushed and the part of... more...

MalaCards based summary: Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to neuronitis and cerebritis. An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Neuroscience. Affiliated tissues include spinal cord, brain and monocytes, and related mouse phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased shRNA abundance (Z-score < -2).

Related Diseases for Wallerian Degeneration

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Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to wallerian degeneration

Symptoms & Phenotypes for Wallerian Degeneration

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GenomeRNAi Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00210-A10.0ERBB2, NRP2, SEMA3A, SEMA3F, VEGFA
2GR00366-A-849.5CNTF, ERBB2, SEMA3A, UBE4B

MGI Mouse Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4CLU, CNTF, ERBB2, NMNAT2, NRP2, UBE4B
2MP:00053847.5CNTF, ERBB2, MPZ, NMNAT2, NRP2, ODC1
3MP:00053866.8CLU, CNTF, ERBB2, MAG, MPZ, NMNAT2
4MP:00036315.5CLU, CNTF, ERBB2, MAG, MPZ, NMNAT1

Drugs & Therapeutics for Wallerian Degeneration

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Drugs for Wallerian Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cholineapproved, nutraceuticalPhase 415462-49-7305
Synonyms:
(2-Hydroxyethyl)trimethyl ammonium
(2-Hydroxyethyl)trimethylammonium
(beta-hydroxyethyl)trimethylammonium
2-Hydroxy-N,N,N-trimethyl-ethanaminium
2-Hydroxy-N,N,N-trimethylethanaminium
Bilineurine
Biocolina
Biocoline
Choline
Choline cation
 
Choline ion
Cholinum
Hepacholine
Hormocline
Lipotril
N,N,N-Trimethylethanol-ammonium
N,N,N-Trimethylethanolammonium
N,N,N-trimethylethanol-ammonium
N-trimethylethanolamine
Neocolina
Paresan
trimethylethanolamine
2Nootropic AgentsPhase 4716
3Cytidine Diphosphate CholinePhase 430

Interventional clinical trials:

idNameStatusNCT IDPhase
1Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)RecruitingNCT03046693Phase 4
2Focal Cortical Atrophy After Myocardial Internal CapsuleCompletedNCT01862172

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

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Anatomical Context for Wallerian Degeneration

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MalaCards organs/tissues related to Wallerian Degeneration:

36
Spinal cord, Brain, Monocytes, Cortex, Bone, Bone marrow, Pons

Publications for Wallerian Degeneration

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Articles related to Wallerian Degeneration:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. (28053206)
2017
2
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2. (27732853)
2016
3
MRI findings in a case of spinal cord Wallerian degeneration following trauma. (27744468)
2016
4
Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration. (27999531)
2016
5
Molecular mechanisms in the initiation phase of Wallerian degeneration. (27062141)
2016
6
Neurographic course of Wallerian Degeneration after human peripheral nerve injury. (27875622)
2016
7
Avian axons undergo Wallerian degeneration after injury and stress. (27614771)
2016
8
Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance. (27073362)
2016
9
Wallerian Degeneration in the Corticospinal Tract Following Tumefactive Demyelination: Conventional and Advanced Magnetic Resonance Imaging. (27417915)
2016
10
Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination. (26712109)
2016
11
Prolonged Wallerian degeneration in the corticospinal tract following external capsular hemorrhage. (27206896)
2016
12
SYSTEMIC TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELLS PROMOTES AXONAL REGENERATION AND ANALGESIA IN A MODEL OF WALLERIAN DEGENERATION. (27607534)
2016
13
Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings. (28072502)
2016
14
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury. (27771719)
2016
15
Bilateral Wallerian Degeneration of the Pontocerebellar Tracts. (26171260)
2015
16
Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria. (26686637)
2015
17
TGF-I^1 is critical for Wallerian degeneration after rat sciatic nerve injury. (25451291)
2015
18
Wallerian degeneration of the pontocerebellar fibres secondary to pontine infarction. (26712359)
2015
19
Wallerian degeneration of the bilateral middle cerebellar peduncles. (25586535)
2015
20
Longitudinal three-dimensional-T2WI-SPACE study on wallerian degeneration in cat corticospinal tract and underlying pathology changes. (26218829)
2015
21
Wallerian Degeneration of the Superior Cerebellar Peduncle. (26457633)
2015
22
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. (26419777)
2015
23
Early Wallerian degeneration in a neonate with middle carotid artery stroke. (25443582)
2015
24
Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration. (25206781)
2014
25
Decline of compound muscle action potentials and statistical MUNEs during Wallerian degeneration. (25240559)
2014
26
Wallerian degeneration: an emerging axon death pathway linking injury and disease. (24840802)
2014
27
Wallerian degeneration in the optic nerve stretch-injury model of TBI: a stereological analysis. (25333317)
2014
28
Early corticospinal tract Wallerian degeneration versus mesencephalic substantia nigra degeneration secondary to striatal stroke. (24468328)
2014
29
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. (24252177)
2014
30
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. (25489886)
2014
31
Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. (25046157)
2014
32
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. (25657736)
2014
33
Signaling mechanisms regulating Wallerian degeneration. (24907513)
2014
34
Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. (24895229)
2014
35
Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons. (24285879)
2013
36
Excitotoxicity and Wallerian degeneration as a processes related to cell death in nervous system. (24442984)
2013
37
Protective role of Wallerian degeneration slow (Wld(s)) gene against retinal ganglion cell body damage in a Wallerian degeneration model. (23403739)
2013
38
MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling. (24124570)
2013
39
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria. (23314018)
2013
40
Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat. (23700281)
2013
41
Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke. (23171053)
2013
42
Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degeneration. (23194661)
2013
43
protein expression profiling during wallerian degeneration after rat sciatic nerve injury. (24123051)
2013
44
Similarities between inherited demyelinating neuropathies and Wallerian degeneration: an old repair program may cause myelin and axon perturbation under nonlesion conditions. (23831295)
2013
45
Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury. (23328443)
2013
46
Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve. (23406314)
2013
47
Hyperintense signal in pyramidal tract neurons in postoperative brain tumor: wallerian degeneration or neoplastic dissemination? (24394880)
2013
48
The acute phase of Wallerian degeneration: longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery. (23396161)
2013
49
The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI). (23543618)
2013
50
Natural history and prognostic value of corticospinal tract Wallerian degeneration in intracerebral hemorrhage. (23913508)
2013

Variations for Wallerian Degeneration

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Expression for genes affiliated with Wallerian Degeneration

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Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for genes affiliated with Wallerian Degeneration

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Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5CNTF, NEFM, VEGFA
29.0CLU, MAG, NEFM, NRP2

GO Terms for genes affiliated with Wallerian Degeneration

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Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neurofibrillary tangleGO:00974189.6CLU, NEFM
2axonGO:00304249.0CNTF, NEFM, NRP2, SARM1, SEMA3A

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1branchiomotor neuron axon guidanceGO:002178510.7SEMA3A, SEMA3F
2negative regulation of axon extension involved in axon guidanceGO:004884310.7SEMA3A, SEMA3F
3de novo NAD biosynthetic process from aspartateGO:003462810.7NMNAT1, NMNAT2
4NAD biosynthetic processGO:000943510.7NMNAT1, NMNAT2
5NAD metabolic processGO:001967410.7NMNAT1, NMNAT2
6motor neuron axon guidanceGO:000804510.6ERBB2, SEMA3A
7cell-cell adhesion via plasma-membrane adhesion moleculesGO:009874210.6MAG, MPZ
8facioacoustic ganglion developmentGO:190337510.6NRP2, SEMA3A
9gonadotrophin-releasing hormone neuronal migration to the hypothalamusGO:002182810.6NRP2, SEMA3A
10negative regulation of axon extensionGO:003051710.6MAG, SEMA3A
11growthGO:004000710.5CNTF, VEGFA
12pyridine nucleotide biosynthetic processGO:001936310.5NMNAT1, NMNAT2
13semaphorin-plexin signaling pathway involved in axon guidanceGO:190228710.4SEMA3A, SEMA3F
14axon extension involved in axon guidanceGO:004884610.4NRP2, SEMA3A, SEMA3F
15facial nerve structural organizationGO:002161210.4NRP2, SEMA3A, SEMA3F
16negative chemotaxisGO:005091910.4NRP2, SEMA3A, SEMA3F
17nerve developmentGO:002167510.4NRP2, SEMA3A, SEMA3F
18semaphorin-plexin signaling pathwayGO:007152610.3NRP2, SEMA3A
19neural crest cell migration involved in autonomic nervous system developmentGO:190116610.3NRP2, SEMA3A, SEMA3F
20axonogenesis involved in innervationGO:006038510.3NPTX1, SEMA3A
21regulation of neuron deathGO:190121410.3CLU, SARM1
22trigeminal ganglion developmentGO:006155110.1NRP2, SEMA3A
23semaphorin-plexin signaling pathway involved in neuron projection guidanceGO:190228510.1NRP2, SEMA3A, SEMA3F
24trigeminal nerve structural organizationGO:002163710.0SEMA3A, SEMA3F
25sympathetic ganglion developmentGO:006154910.0NRP2, SEMA3A, SEMA3F
26sympathetic neuron projection extensionGO:009749010.0NRP2, SEMA3A, SEMA3F
27sympathetic neuron projection guidanceGO:009749110.0NRP2, SEMA3A, SEMA3F
28ventral trunk neural crest cell migrationGO:00364869.7NRP2, SEMA3A, SEMA3F
29positive regulation of gene expressionGO:00106289.6CLU, CNTF, ERBB2, VEGFA
30nervous system developmentGO:00073999.1CNTF, ERBB2, MAG, NRP2, SARM1, SEMA3A

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemorepellent activityGO:004549910.1SEMA3A, SEMA3F
2nicotinamide-nucleotide adenylyltransferase activityGO:000030910.0NMNAT1, NMNAT2
3nicotinate-nucleotide adenylyltransferase activityGO:000451510.0NMNAT1, NMNAT2

Sources for Wallerian Degeneration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet