MCID: WLL004
MIFTS: 40

Wallerian Degeneration

Categories: Rare diseases

Aliases & Classifications for Wallerian Degeneration

MalaCards integrated aliases for Wallerian Degeneration:

Name: Wallerian Degeneration 49 51 69
Wallerian Degeneration of the Pyramidal Tract 49

Classifications:



External Ids:

UMLS 69 C0043020

Summaries for Wallerian Degeneration

MalaCards based summary : Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to neuronitis and cerebritis. An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Choline and Cytidine Diphosphate Choline have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and monocytes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Wallerian degeneration is a process that results when a nerve fiber is cut or crushed and the part of... more...

Related Diseases for Wallerian Degeneration

Diseases related to Wallerian Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 neuronitis 10.4
2 cerebritis 10.3
3 cervicitis 10.3
4 spinal cord injury 10.3
5 neuropathy 10.2
6 multiple sclerosis 10.2
7 episodic pain syndrome, familial, 1 10.1
8 ischemia 10.1
9 retinitis 10.1
10 hydrops, lactic acidosis, and sideroblastic anemia 10.1
11 brain injury 10.1
12 aging 10.1
13 stroke, ischemic 10.1
14 relapsing-remitting multiple sclerosis 10.0
15 middle cerebral artery infarction 10.0
16 hypoxia 10.0
17 niemann-pick disease, type a 9.9 MAG MPZ
18 mononeuropathy 9.8
19 encephalitis 9.8
20 hyperprolactinemia 9.8
21 allergic hypersensitivity disease 9.8
22 cerebral hypoxia 9.8
23 alexia 9.8
24 dysautonomia 9.8
25 neuritis 9.8
26 encephalopathy 9.8
27 charcot-marie-tooth disease 9.8
28 head injury 9.8
29 retinal ischemia 9.8
30 endotheliitis 9.8
31 acute sensory ataxic neuropathy 9.8
32 spinal muscular atrophy 9.8
33 colchicine poisoning 9.8
34 blood group, i system 9.8
35 traumatic brain injury 9.8
36 progressive multifocal leukoencephalopathy 9.8
37 lymphoma 9.8
38 prion disease 9.8
39 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
40 agraphia 9.8
41 cerebrovascular disease 9.8
42 sudanophilic cerebral sclerosis 9.8
43 thrombosis 9.8
44 muscular atrophy 9.8
45 leukodystrophy 9.8
46 tooth disease 9.8
47 myocarditis 9.8
48 hemorrhage, intracerebral 9.8
49 hemiplegia 9.8
50 diabetic neuropathy 9.7 CNTF MPZ VEGFA

Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to Wallerian Degeneration

Symptoms & Phenotypes for Wallerian Degeneration

GenomeRNAi Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.53 UBE4B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.53 CNTF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.53 UBE4B CNTF ERBB2 SEMA3A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.53 CNTF
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.53 UBE4B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.53 CNTF
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.53 CNTF SEMA3A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.53 SEMA3A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.53 SEMA3A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.53 ERBB2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.53 ERBB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.53 CNTF
13 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 SEMA3F VEGFA ERBB2 NRP2 SEMA3A

MGI Mouse Phenotypes related to Wallerian Degeneration:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 VEGFA MPZ SIRT2 NMNAT1 NMNAT2 UBE4B
2 cellular MP:0005384 10.03 VEGFA SEMA3F MPZ SIRT2 NMNAT2 UBE4B
3 mortality/aging MP:0010768 9.93 VEGFA SEMA3F MPZ NMNAT1 SIRT2 NMNAT2
4 muscle MP:0005369 9.5 VEGFA NMNAT2 UBE4B CLU NRP2 CNTF
5 nervous system MP:0003631 9.5 SIRT2 NMNAT1 NMNAT2 UBE4B NPTX1 VEGFA

Drugs & Therapeutics for Wallerian Degeneration

Drugs for Wallerian Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Choline Approved, Nutraceutical Phase 4 62-49-7 305
2 Cytidine Diphosphate Choline Phase 4
3 Nootropic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Focal Cortical Atrophy After Myocardial Internal Capsule Completed NCT01862172
3 Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain Recruiting NCT03327220

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

Anatomical Context for Wallerian Degeneration

MalaCards organs/tissues related to Wallerian Degeneration:

38
Spinal Cord, Brain, Monocytes, Cortex, Bone, Bone Marrow, Pituitary

Publications for Wallerian Degeneration

Articles related to Wallerian Degeneration:

(show top 50) (show all 540)
# Title Authors Year
1
Deficiency of adaptive immunity does not interfere with Wallerian degeneration. ( 28475650 )
2017
2
Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. ( 28285993 )
2017
3
Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. ( 28441556 )
2017
4
Wallerian degeneration of the bilateral middle cerebellar peduncles secondary to pontine infarction. ( 29285691 )
2017
5
An assessment of the correlation between early postinfarction pyramidal tract Wallerian degeneration and nerve function recovery using diffusion tensor imaging. ( 28128402 )
2017
6
Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction. ( 29076904 )
2017
7
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. ( 28053206 )
2017
8
Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis. ( 28302146 )
2017
9
Critical signaling pathways during Wallerian degeneration of peripheral nerve. ( 28761435 )
2017
10
Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration. ( 28912156 )
2017
11
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency InA Vivo. ( 28262487 )
2017
12
Teaching NeuroImages: Wallerian degeneration in evolving pediatric stroke. ( 28947589 )
2017
13
Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves. ( 28239339 )
2017
14
Avian axons undergo Wallerian degeneration after injury and stress. ( 27614771 )
2016
15
Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings. ( 28072502 )
2016
16
SYSTEMIC TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELLS PROMOTES AXONAL REGENERATION AND ANALGESIA IN A MODEL OF WALLERIAN DEGENERATION. ( 27607534 )
2016
17
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury. ( 27771719 )
2016
18
Prolonged Wallerian degeneration in the corticospinal tract following external capsular hemorrhage. ( 27206896 )
2016
19
Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination. ( 26712109 )
2016
20
Molecular mechanisms in the initiation phase of Wallerian degeneration. ( 27062141 )
2016
21
T2/Fluid Attenuation Inversion Recovery Hypointensity of Corticospinal Tracts due to Subacute Stage of Wallerian Degeneration. ( 28163512 )
2016
22
Neurographic course of Wallerian Degeneration after human peripheral nerve injury. ( 27875622 )
2016
23
Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance. ( 27073362 )
2016
24
Wallerian Degeneration in the Corticospinal Tract Following Tumefactive Demyelination: Conventional and Advanced Magnetic Resonance Imaging. ( 27417915 )
2016
25
Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration. ( 27999531 )
2016
26
MRI findings in a case of spinal cord Wallerian degeneration following trauma. ( 27744468 )
2016
27
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2. ( 27732853 )
2016
28
TGF-I^1 is critical for Wallerian degeneration after rat sciatic nerve injury. ( 25451291 )
2015
29
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. ( 26419777 )
2015
30
Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria. ( 26686637 )
2015
31
Early Wallerian degeneration in a neonate with middle carotid artery stroke. ( 25443582 )
2015
32
Wallerian degeneration of the bilateral middle cerebellar peduncles. ( 25586535 )
2015
33
Wallerian degeneration of the pontocerebellar fibres secondary to pontine infarction. ( 26712359 )
2015
34
Wallerian Degeneration of the Superior Cerebellar Peduncle. ( 26457633 )
2015
35
Longitudinal three-dimensional-T2WI-SPACE study on wallerian degeneration in cat corticospinal tract and underlying pathology changes. ( 26218829 )
2015
36
Bilateral Wallerian Degeneration of the Pontocerebellar Tracts. ( 26171260 )
2015
37
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
38
Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. ( 25046157 )
2014
39
Decline of compound muscle action potentials and statistical MUNEs during Wallerian degeneration. ( 25240559 )
2014
40
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. ( 25657736 )
2014
41
Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. ( 24895229 )
2014
42
Wallerian degeneration: an emerging axon death pathway linking injury and disease. ( 24840802 )
2014
43
Signaling mechanisms regulating Wallerian degeneration. ( 24907513 )
2014
44
Wallerian degeneration in the optic nerve stretch-injury model of TBI: a stereological analysis. ( 25333317 )
2014
45
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. ( 24252177 )
2014
46
Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration. ( 25206781 )
2014
47
Early corticospinal tract Wallerian degeneration versus mesencephalic substantia nigra degeneration secondary to striatal stroke. ( 24468328 )
2014
48
Excitotoxicity and Wallerian degeneration as a processes related to cell death in nervous system. ( 24442984 )
2013
49
Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons. ( 24285879 )
2013
50
Natural history and prognostic value of corticospinal tract Wallerian degeneration in intracerebral hemorrhage. ( 23913508 )
2013

Variations for Wallerian Degeneration

Expression for Wallerian Degeneration

Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for Wallerian Degeneration

Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 CLU MAG NEFM NRP2
2 10.7 CNTF NEFM VEGFA

GO Terms for Wallerian Degeneration

Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paranode region of axon GO:0033270 9.32 MAG SIRT2
2 Schmidt-Lanterman incisure GO:0043220 9.26 MAG SIRT2
3 myelin sheath GO:0043209 9.26 ERBB2 MAG MPZ SIRT2
4 neurofibrillary tangle GO:0097418 9.16 CLU NEFM
5 axon GO:0030424 9.02 CNTF NEFM NRP2 SARM1 SEMA3A

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.92 CNTF ERBB2 MAG NRP2 SARM1 SEMA3A
2 negative chemotaxis GO:0050919 9.67 NRP2 SEMA3A SEMA3F
3 nerve development GO:0021675 9.65 NRP2 SEMA3A SEMA3F
4 regulation of neuron death GO:1901214 9.64 CLU SARM1
5 motor neuron axon guidance GO:0008045 9.64 ERBB2 SEMA3A
6 negative regulation of axon extension GO:0030517 9.63 MAG SEMA3A
7 NAD metabolic process GO:0019674 9.63 NMNAT1 NMNAT2
8 facial nerve structural organization GO:0021612 9.63 NRP2 SEMA3A SEMA3F
9 NAD biosynthetic process GO:0009435 9.62 NMNAT1 NMNAT2
10 growth GO:0040007 9.61 CNTF VEGFA
11 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.61 MAG MPZ
12 sympathetic ganglion development GO:0061549 9.61 NRP2 SEMA3A SEMA3F
13 pyridine nucleotide biosynthetic process GO:0019363 9.6 NMNAT1 NMNAT2
14 negative regulation of axon extension involved in axon guidance GO:0048843 9.59 SEMA3A SEMA3F
15 branchiomotor neuron axon guidance GO:0021785 9.58 SEMA3A SEMA3F
16 trigeminal nerve structural organization GO:0021637 9.58 SEMA3A SEMA3F
17 axon extension involved in axon guidance GO:0048846 9.58 NRP2 SEMA3A SEMA3F
18 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.57 SEMA3A SEMA3F
19 axonogenesis involved in innervation GO:0060385 9.56 NPTX1 SEMA3A
20 trigeminal ganglion development GO:0061551 9.55 NRP2 SEMA3A
21 de novo NAD biosynthetic process from aspartate GO:0034628 9.54 NMNAT1 NMNAT2
22 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.54 NRP2 SEMA3A SEMA3F
23 facioacoustic ganglion development GO:1903375 9.52 NRP2 SEMA3A
24 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.51 NRP2 SEMA3A
25 sympathetic neuron projection extension GO:0097490 9.43 NRP2 SEMA3A SEMA3F
26 sympathetic neuron projection guidance GO:0097491 9.33 NRP2 SEMA3A SEMA3F
27 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.13 NRP2 SEMA3A SEMA3F
28 ventral trunk neural crest cell migration GO:0036486 8.8 NRP2 SEMA3A SEMA3F
29 cell differentiation GO:0030154 10.09 CNTF NRP2 SARM1 SEMA3A SIRT2 VEGFA

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropilin binding GO:0038191 9.26 SEMA3A SEMA3F
2 chemorepellent activity GO:0045499 9.16 SEMA3A SEMA3F
3 nicotinate-nucleotide adenylyltransferase activity GO:0004515 8.96 NMNAT1 NMNAT2
4 nicotinamide-nucleotide adenylyltransferase activity GO:0000309 8.62 NMNAT1 NMNAT2

Sources for Wallerian Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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