MCID: WLL004
MIFTS: 35

Wallerian Degeneration malady

Category: Rare diseases

Aliases & Classifications for Wallerian Degeneration

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Aliases & Descriptions for Wallerian Degeneration:

Name: Wallerian Degeneration 47 49 67
 
Wallerian Degeneration of the Pyramidal Tract 47

Classifications:



Summaries for Wallerian Degeneration

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Wikipedia:70 Wallerian degeneration is a process that results when a nerve fiber is cut or crushed, in which the part... more...

MalaCards based summary: Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to neuronitis and mucinous cystadenocarcinoma, and has symptoms including psychomotor skills impaired An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Neuroscience. Affiliated tissues include spinal cord, brain and monocytes, and related mouse phenotypes are muscle and mortality/aging.

Related Diseases for Wallerian Degeneration

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Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to wallerian degeneration

Symptoms for Wallerian Degeneration

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UMLS symptoms related to Wallerian Degeneration:


psychomotor skills impaired

Drugs & Therapeutics for Wallerian Degeneration

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Focal Cortical Atrophy After Myocardial Internal CapsuleCompletedNCT01862172Early Phase 1

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

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Anatomical Context for Wallerian Degeneration

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MalaCards organs/tissues related to Wallerian Degeneration:

35
Spinal cord, Brain, Monocytes, Cortex, Bone, Bone marrow, Pons

Animal Models for Wallerian Degeneration or affiliated genes

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MGI Mouse Phenotypes related to Wallerian Degeneration:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3CLU, CNTF, ERBB2, NMNAT2, NRP2, UBE4B
2MP:00107687.5ERBB2, MPZ, NMNAT1, NMNAT2, NRP2, ODC1
3MP:00053847.4CNTF, ERBB2, MPZ, NMNAT2, NRP2, ODC1
4MP:00053866.9CLU, CNTF, ERBB2, MAG, MPZ, NMNAT2
5MP:00036315.5CLU, CNTF, ERBB2, MAG, MPZ, NMNAT1

Publications for Wallerian Degeneration

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Articles related to Wallerian Degeneration:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance. (27073362)
2016
2
SYSTEMIC TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELLS PROMOTES AXONAL REGENERATION AND ANALGESIA IN A MODEL OF WALLERIAN DEGENERATION. (27607534)
2016
3
Bilateral Wallerian Degeneration of the Pontocerebellar Tracts. (26171260)
2015
4
TGF-I^1 is critical for Wallerian degeneration after rat sciatic nerve injury. (25451291)
2015
5
Wallerian Degeneration of the Superior Cerebellar Peduncle. (26457633)
2015
6
Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat. (23700281)
2013
7
The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI). (23543618)
2013
8
Adenosine 5'-Triphosphate (ATP) Inhibits Schwann Cell Demyelination During Wallerian Degeneration. (24363123)
2013
9
Protective role of Wallerian degeneration slow (Wld(s)) gene against retinal ganglion cell body damage in a Wallerian degeneration model. (23403739)
2013
10
Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. (18374600)
2008
11
Why is Wallerian degeneration in the CNS so slow? (17506644)
2007
12
Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degeneration. (17027917)
2006
13
Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve. (15698630)
2005
14
Bilateral Wallerian degeneration of the middle cerebellar peduncles due to paramedian pontine infarction: MRI findings. (15526095)
2004
15
Wallerian degeneration as a window to peripheral neuropathy. (15140618)
2004
16
Wallerian degeneration of the middle cerebellar peduncle after pontine infarction: MR imaging. (15053174)
2004
17
Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein. (15542243)
2004
18
Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke. (15275932)
2004
19
Autonomic dysreflexia after spinal cord transection or compression in 129Sv, C57BL, and Wallerian degeneration slow mutant mice. (12957497)
2003
20
Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse. (11891043)
2002
21
Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration. (12112437)
2002
22
Watery and dark axons in Wallerian degeneration of the opossum's optic nerve: different patterns of cytoskeletal breakdown? (11404785)
2001
23
Cellular activity of resident macrophages during Wallerian degeneration. (11015722)
2000
24
Effect of liposome-mediated macrophage depletion on Schwann cell proliferation during Wallerian degeneration. (11011819)
2000
25
Altered brain metabolism in the C57BL/Wld mouse strain detected by magnetic resonance spectroscopy: association with delayed Wallerian degeneration? (10500267)
1999
26
Germinoma causing wallerian degeneration. Case report and review of the literature. (9420084)
1998
27
The role of macrophages in Wallerian degeneration. (9161725)
1997
28
Genetic influences on cellular reactions to spinal cord injury: activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration. (8842900)
1996
29
Wallerian degeneration in peripheral nerve disease. (8732200)
1996
30
Persistence of neuromuscular junctions after axotomy in mice with slow Wallerian degeneration (C57BL/WldS). (7551190)
1995
31
Pyramidal tract Wallerian degeneration and correlated symptoms in stroke. (8168577)
1994
32
Prolonged T1 values of the crushed nerve are not exclusively attributable to Wallerian degeneration or endoneurial edema. (21551670)
1992
33
The role of complement in myelin phagocytosis during PNS wallerian degeneration. (1880536)
1991
34
Could Wallerian degeneration contribute to "leuko-araiosis" in subjects free of any vascular disorder? (2010759)
1991
35
Coronal MR imaging for visualization of wallerian degeneration of the pyramidal tract. (1885798)
1991
36
MR imaging of wallerian degeneration in the human brain stem after ictus. (2215902)
1990
37
Wallerian degeneration and inflammation in rat peripheral nerve detected by in vivo MR imaging. (2549771)
1989
38
Collagenosis in wallerian degeneration depends on peripheral nerve type. (3366204)
1988
39
The rate of Wallerian degeneration in the absence of immunoglobulins. A study in chick and mouse peripheral nerve. (3251578)
1988
40
Observations on Wallerian degeneration in explant cultures of cat sciatic nerve. (3746356)
1986
41
Myelin proteins in Wallerian degeneration of the optic nerve. (6683664)
1983
42
Electron microscopy study of astrocytic reaction in Wallerian degeneration of the rabbit optic nerve. (7183932)
1982
43
Wallerian degeneration of the optic nerve in light of histological and biochemical studies. (6939271)
1981
44
Ultrastructural sequence of myelin degradation. I. Wallerian degeneration in the rat optic nerve. (213928)
1978
45
Biochemical studies of myelin in Wallerian degeneration of rat optic nerve. (4687199)
1973
46
The role of oligodendroglia and astroglia in Wallerian degeneration of the optic nerve. (4204124)
1973
47
Histochemistry of myelin. IX. Neutral and acid proteinases in early Wallerian degeneration. (5525782)
1970
48
Electron microscopic studies of Wallerian degeneration in rat optic nerves. I. The multipotential glia. (4319510)
1970
49
Augustus Volney Waller (1816-1870). Wallerian degeneration. (4891558)
1969
50
Electron microscopic study of Wallerian degeneration in cutaneous nerves caused by mechanical injury. (6074501)
1967

Variations for Wallerian Degeneration

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Expression for genes affiliated with Wallerian Degeneration

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Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for genes affiliated with Wallerian Degeneration

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Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5CNTF, NEFM, VEGFA
29.1CLU, MAG, NEFM, NRP2

GO Terms for genes affiliated with Wallerian Degeneration

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Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neurofibrillary tangleGO:009741810.1CLU, NEFM
2axonGO:00304248.9CNTF, NEFM, NRP2, SARM1, SEMA3A

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1trigeminal nerve structural organizationGO:002163710.4SEMA3A, SEMA3F
2semaphorin-plexin signaling pathway involved in axon guidanceGO:190228710.4SEMA3A, SEMA3F
3gonadotrophin-releasing hormone neuronal migration to the hypothalamusGO:002182810.4NRP2, SEMA3A
4branchiomotor neuron axon guidanceGO:002178510.4SEMA3A, SEMA3F
5facioacoustic ganglion developmentGO:190337510.4NRP2, SEMA3A
6de novo NAD biosynthetic process from aspartateGO:003462810.3NMNAT1, NMNAT2
7NAD metabolic processGO:001967410.3NMNAT1, NMNAT2
8trigeminal ganglion developmentGO:006155110.3NRP2, SEMA3A
9motor neuron axon guidanceGO:000804510.2ERBB2, SEMA3A
10sympathetic neuron projection extensionGO:009749010.1NRP2, SEMA3A, SEMA3F
11facial nerve structural organizationGO:002161210.1NRP2, SEMA3A, SEMA3F
12semaphorin-plexin signaling pathway involved in neuron projection guidanceGO:190228510.1NRP2, SEMA3A, SEMA3F
13ventral trunk neural crest cell migrationGO:003648610.1NRP2, SEMA3A, SEMA3F
14neural crest cell migration involved in autonomic nervous system developmentGO:190116610.1NRP2, SEMA3A, SEMA3F
15sympathetic neuron projection guidanceGO:009749110.1NRP2, SEMA3A, SEMA3F
16NAD biosynthetic processGO:000943510.1NMNAT1, NMNAT2
17axon extension involved in axon guidanceGO:004884610.0NRP2, SEMA3A, SEMA3F
18negative chemotaxisGO:005091910.0NRP2, SEMA3A, SEMA3F
19neural crest cell migrationGO:00017559.9NRP2, SEMA3A, SEMA3F
20axonogenesis involved in innervationGO:00603859.8NPTX1, SEMA3A
21regulation of neuron deathGO:19012149.8CLU, SARM1
22sympathetic ganglion developmentGO:00615499.6NRP2, SEMA3A, SEMA3F
23nerve developmentGO:00216759.4NRP2, SEMA3A, SEMA3F

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nicotinamide-nucleotide adenylyltransferase activityGO:000030910.2NMNAT1, NMNAT2
2nicotinate-nucleotide adenylyltransferase activityGO:000451510.2NMNAT1, NMNAT2
3semaphorin receptor bindingGO:003021510.0SEMA3A, SEMA3F
4neuropilin bindingGO:00381919.7SEMA3A, SEMA3F

Sources for Wallerian Degeneration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet