MCID: WRF001
MIFTS: 41

Warfarin Resistance malady

Genetic diseases (common) category

Summaries for Warfarin Resistance

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MalaCards based summary: Warfarin Resistance is related to thromboembolism and factor v deficiency. An important gene associated with Warfarin Resistance is VKORC1 (vitamin K epoxide reductase complex, subunit 1), and among its related pathways are Naphthalene metabolism and Caffeine Pathway, Pharmacokinetics. The compounds sparteine and tienilic acid have been mentioned in the context of this disorder. Affiliated tissues include liver.

Description from OMIM:46 122700

Aliases & Classifications for Warfarin Resistance

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Sources:
46OMIM, 44Novoseek, 61UMLS
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Warfarin Resistance, Aliases & Descriptions:

Name: Warfarin Resistance 46 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Warfarin Resistance

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Diseases related to Warfarin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism29.9F2, F9, CYP2C9, TTF2
2factor v deficiency10.4F2
3factor xii deficiency10.4F9
4dysfibrinogenemia10.4F2
5hypersplenism10.4F2
6coumarin resistance10.3CYP2A6
7vitamin k deficiency hemorrhagic disease10.3VKORC1, F2
8warfarin sensitivity10.2CYP2C9, F9
9short bowel syndrome10.2
10factor x deficiency10.2F2, F9
11factor xi deficiency10.2F9, F2
12hemorrhagic disease10.2F2, F9
13von willebrand's disease10.2F2, F9
14factor vii deficiency10.2F2, F9
15factor viii deficiency10.2F9, F2
16bernard-soulier syndrome10.2F2, F9
17protein c deficiency10.2F2, F9
18hemophilia b10.2F2, F9
19esophageal varix10.2F2, ALB
20autoimmune hepatitis10.2CYP2C9, F2
21acute liver failure10.2F2, ALB
22thrombophilia10.2F2, F9
23hepatorenal syndrome10.1F2, ALB
24varicose veins10.1F2, ALB
25disseminated intravascular coagulation10.1F9, F2
26alcoholic hepatitis10.1F2, ALB
27hepatic encephalopathy10.1F2, ALB
28portal hypertension10.1F2, ALB
29bilirubin metabolic disorder10.1ALB, F2
30venous thrombosis10.1F2, F9
31hepatitis b10.1F2, ALB
32leukopenia10.1ALB, F2
33galactosemia10.1ALB, F2
34myocardial infarction10.1
35priapism10.1
36peritonitis10.1F2, ALB
37cork-handlers' disease10.0ALB, F2
38hepatitis10.0ALB, F2
39brain disease10.0ALB, TTF2, F2
40connective tissue disease10.0F2, ALB
41viral hepatitis10.0F2, CYP2A6
42stroke, ischemic10.0ALB, F2
43chronic kidney failure10.0CYP2C9, TTF2, ALB
44pulmonary embolism9.9ALB, F9, F2
45hyperhomocysteinemia9.9ALB, F9, F2
46thrombocytopenia9.9ALB, F9, F2
47amyloidosis9.9F9, ALB
48insulin resistance9.9F9, TTF2, ALB
49factor v leiden thrombophilia9.9VKORC1, CYP2C9, F9, F2
50herpes simplex9.9TTF2, CYP2A6, F9

Graphical network of the top 20 diseases related to Warfarin Resistance:



Diseases related to warfarin resistance

Symptoms for Warfarin Resistance

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Clinical features from OMIM:

122700

Drugs & Therapeutics for Warfarin Resistance

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Drug clinical trials:

Search ClinicalTrials for Warfarin Resistance

Search NIH Clinical Center for Warfarin Resistance

Genetic Tests for Warfarin Resistance

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Anatomical Context for Warfarin Resistance

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MalaCards organs/tissues related to Warfarin Resistance:

32
Liver

Animal Models for Warfarin Resistance or affiliated genes

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Publications for Warfarin Resistance

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Articles related to Warfarin Resistance:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
C3435T polymorphism of MDR1 gene with warfarin resistance. (23872171)
2013
2
A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay. (23452238)
2013
3
Warfarin resistance associated with parenteral nutrition. (22143126)
2012
4
An instructive case suggesting warfarin resistance which is independent on the regulation of the CYP2C9 and VKORC1 genotype. (22338910)
2011
5
Warfarin resistance induced by oxcarbamazepine. (19666450)
2009
6
An algorithm for managing warfarin resistance. (19952297)
2009
7
Assaying of warfarin in Iranian warfarin resistance patients blood by HPLC. (18817151)
2008
8
Azathioprine-induced warfarin resistance. (18505911)
2008
9
VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals. (18362220)
2008
10
Warfarin resistance. (18776969)
2008
11
Inherited warfarin resistance in Indian patients: does it occur? (17636200)
2007
12
A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance. (17110455)
2007
13
Inherited warfarin resistance in Indian patients: does it occur? (17911202)
2007
14
Warfarin resistance: interaction between warfarin and Eruca sativa L. (16741856)
2006
15
Warfarin resistance in a French strain of rats. (16421894)
2005
16
Warfarin resistance in a patient with mechanical valve prosthesis. (15770320)
2005
17
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (14765194)
2004
18
Warfarin resistance and enteral feedings: 2 case reports and a supporting in vitro study. (11552202)
2001
19
A molecular mechanism for genetic warfarin resistance in the rat. (11641264)
2001
20
Genomic assignment of the warfarin resistance locus, Rw, in the rat. (10384042)
1999
21
Warfarin resistance in a patient with short bowel syndrome. (9620117)
1998
22
Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant-associated priapism. (9803981)
1998
23
Warfarin resistance induced by teicoplanin. (9407741)
1997
24
Warfarin resistance: diagnosis and therapeutic alternatives. (8947972)
1996
25
Hereditary warfarin resistance. (8134868)
1994
26
Warfarin resistance due to malabsorption. (7931050)
1994
27
Warfarin resistance and enteral feedings. (2496251)
1989
28
Warfarin resistance: biochemical evaluation of a warfarin-resistant wild brown rat. (2783170)
1989
29
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987
30
Warfarin resistance associated with intravenous lipid administration. (3110450)
1987
31
Familial warfarin resistance in a black child. (3799934)
1986
32
Warfarin resistance linked to enteral nutrition products. (3998343)
1985
33
Fuzzy: a genetic marker for warfarin resistance in the Norway rat. (3889495)
1985
34
Myocardial infarction after diet-induced warfarin resistance. (6486994)
1984
35
Warfarin resistance with nafcillin therapy. (6703546)
1984
36
Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. (6726460)
1984
37
Multiple allelism at the locus controlling warfarin resistance in the Norway rat. (7141222)
1982
38
Warfarin resistance caused by vitamin K in intestinal feeds. (6815440)
1982
39
Liquid nutrition as a cause of warfarin resistance. (7270565)
1981
40
Relative fitness of genotypes in a population of Rattus norvegicus polymorphic for warfarin resistance. (295047)
1979
41
Warfarin-resistance genotype determination in the Norway rat, Rattus norvegicus. (553191)
1979
42
Genetics of warfarin-resistance in house mice of three separate localities. (621381)
1978
43
Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark. (892442)
1977
44
A major gene controlling warfarin-resistance in the house mouse. (1063212)
1976
45
Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K 1 . (4699235)
1973
46
Warfarin resistance and vitamin K requirement in the rat. (4712304)
1973
47
The biochemistry of warfarin resistance in the rat. (5472172)
1970
48
The warfarin resistance problem in England and Wales. (5293926)
1969
49
Warfarin-resistance in the Netherlands. (5293930)
1969
50
Warfarin resistance in the rat. (5671000)
1968

Variations for Warfarin Resistance

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UniProtKB/Swiss-Prot genetic disease variations for Warfarin Resistance:

63 (show all 18)
id Symbol AA change Variation ID SNP ID
1VKORC1p.Val29LeuVAR_021821rs104894539
2VKORC1p.Val45AlaVAR_021822rs104894540
3VKORC1p.Arg58GlyVAR_021823rs104894541
4VKORC1p.Leu128ArgVAR_021825rs104894542
5VKORC1p.Ala26ThrVAR_065785
6VKORC1p.Asp36GlyVAR_065786
7VKORC1p.Asp36TyrVAR_065787
8VKORC1p.Ser52TrpVAR_065788
9VKORC1p.Ser56PheVAR_065789
10VKORC1p.Trp59CysVAR_065790
11VKORC1p.Trp59LeuVAR_065791
12VKORC1p.Val66GlyVAR_065792
13VKORC1p.Val66MetVAR_065793rs72547529
14VKORC1p.Gly71AlaVAR_065794
15VKORC1p.Asn77SerVAR_065795
16VKORC1p.Asn77TyrVAR_065796
17VKORC1p.Ile123AsnVAR_065797
18VKORC1p.Tyr139HisVAR_065798

Clinvar genetic disease variations for Warfarin Resistance:

7 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1F9F9, ALA-10THRsingle nucleotide variantPathogenic
2F9F9, ALA-10VALundetermined variantPathogenic
3CYP2A6NM_000762.5(CYP2A6): c.479T> A (p.Leu160His)single nucleotide variantPathogenicrs1801272GRCh37Chr 19, 41354533: 41354533
4CYP2A6CYP2A6*12AdeletionPathogenic
5VKORC1NM_024006.4(VKORC1): c.85G> T (p.Val29Leu)single nucleotide variantPathogenicrs104894539GRCh37Chr 16, 31105966: 31105966
6VKORC1NM_024006.4(VKORC1): c.134T> C (p.Val45Ala)single nucleotide variantPathogenicrs104894540GRCh37Chr 16, 31105917: 31105917
7VKORC1NM_024006.4(VKORC1): c.172A> G (p.Arg58Gly)single nucleotide variantPathogenicrs104894541GRCh37Chr 16, 31105879: 31105879
8VKORC1NM_024006.4(VKORC1): c.383T> G (p.Leu128Arg)single nucleotide variantPathogenicrs104894542GRCh37Chr 16, 31102564: 31102564
9VKORC1NM_024006.4(VKORC1): c.-1639G> Asingle nucleotide variantdrug responsers9923231GRCh37Chr 16, 31107689: 31107689
10VKORC1NM_024006.4(VKORC1): c.106G> T (p.Asp36Tyr)single nucleotide variantPathogenicrs61742245GRCh37Chr 16, 31105945: 31105945
11VKORC1NM_024006.4(VKORC1): c.174-136C> Tsingle nucleotide variantdrug responsers9934438GRCh37Chr 16, 31104878: 31104878
12NM_024006.4(VKORC1): c.-1588dupGduplicationdrug responsers397509427GRCh37Chr 16, 31107637: 31107638
13CYP2C9NM_000771.3(CYP2C9): c.1075A> C (p.Ile359Leu)single nucleotide variantdrug responsers1057910GRCh37Chr 10, 96741053: 96741053
14CYP2C9NM_000771.3(CYP2C9): c.430C> T (p.Arg144Cys)single nucleotide variantconfers sensitivityrs1799853GRCh37Chr 10, 96702047: 96702047
15CYP2C9NM_000771.3(CYP2C9): c.622T> G (p.Leu208Val)single nucleotide variantPathogenicrs72558191GRCh37Chr 10, 96707676: 96707676

Expression for genes affiliated with Warfarin Resistance

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Expression patterns in normal tissues for genes affiliated with Warfarin Resistance

Search GEO for disease gene expression data for Warfarin Resistance.

Pathways for genes affiliated with Warfarin Resistance

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Pathways related to Warfarin Resistance according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CYP2C9, CYP2A6
2
Show member pathways
9.8CYP2C9, CYP2A6
3
Show member pathways
Retinol metabolism59
9.8CYP2A6, CYP2C9
49.8CYP2A6, CYP2C9
59.8CYP2A6, CYP2C9
6
Show member pathways
9.4F9, F2
79.2ALB, F9
8
Show member pathways
9.1VKORC1, F9, F2
99.0ALB, F2
10
Show member pathways
8.7VKORC1, MCFD2, F9, F2

Compounds for genes affiliated with Warfarin Resistance

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Compounds related to Warfarin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 209)
idCompoundScoreTop Affiliating Genes
1sparteine44 1211.1CYP2C9, CYP2A6
2tienilic acid4410.0CYP2A6, CYP2C9
3thiophene4410.0CYP2A6, CYP2C9
4vortioxetine5010.0CYP2A6, CYP2C9
5fluindione50 4410.9VKORC1, F2
6mononine449.8F9, F2
7epoxide449.8VKORC1, CYP2C9, CYP2A6
87-ethoxy-4-trifluoromethylcoumarin449.8CYP2A6, CYP2C9
9organon449.7F9, F2
10ximelagatran44 1210.7F2, CYP2C9
11sulfisoxazole44 50 60 1212.6CYP2C9, ALB
12vitamin k epoxide449.6CYP2C9, VKORC1, F2
13kaolin449.6F2, F9
14rifampicin44 29 6011.6TTF2, CYP2A6, CYP2C9
15r-warfarin449.6VKORC1, F2, CYP2A6
16s-warfarin449.6CYP2C9, CYP2A6, F2
17gamma-carboxyglutamic acid449.5VKORC1, F2, F9
18lidocaine44 29 1211.5F2, CYP2A6, CYP2C9
19vitamin k144 2510.4VKORC1, F2
20cefotetan44 1210.4ALB, F2
21dextran 70449.4ALB, F2
22tween 80449.4F9, ALB
23nortriptyline50 44 29 1212.3CYP2C9, CYP2A6, ALB
24amlodipine44 50 25 1212.3CYP2C9, ALB, CYP2A6
25fluorouracil50 1210.3CYP2A6, CYP2C9, ALB
26propofol44 50 1211.3CYP2A6, CYP2C9, ALB
27hepaplastin449.3ALB, F2
28diazepam44 29 50 1212.3CYP2A6, CYP2C9, ALB
29phenytoin44 50 29 1212.3ALB, CYP2C9, CYP2A6
30halothane44 50 29 1212.3CYP2A6, CYP2C9, ALB
31terlipressin44 1210.3F2, ALB
32zidovudine44 50 1211.2ALB, CYP2A6, CYP2C9
33cefoperazone44 1210.2F2, ALB
34acetaminophen44 3 50 25 1213.1F9, CYP2C9, CYP2A6, F2
35dextran449.1TTF2, F9, ALB
36phenylbutazone44 1210.1CYP2C9, ALB, F2
37fosphenytoin44 1210.0CYP2C9, ALB
38estrone44 29 25 1212.0CYP2C9, ALB, CYP2A6
39kininogen449.0F2, ALB, F9
40valproic acid44 50 25 1211.9ALB, CYP2C9, CYP2A6
41cyclosporin a44 29 6010.9CYP2C9, F9, TTF2, F2
42coumarins448.9VKORC1, CYP2C9, CYP2A6, F9, F2
43coumarin44 3 50 2511.8CYP2C9, CYP2A6, F9, F2, VKORC1
44diclofenac44 29 50 1211.8ALB, TTF2, CYP2C9, CYP2A6
45antipyrine44 129.8CYP2C9, CYP2A6, F2, ALB
46menadione44 25 1210.7F2, CYP2A6, VKORC1, VKORC1L1, F9
47fibrinogen448.5F2, F9, TTF2, ALB
48acenocoumarol44 50 1210.4F9, CYP2C9, VKORC1, ALB, F2
49phenprocoumon44 50 1210.4ALB, CYP2C9, VKORC1, F9, F2
50warfarin44 50 25 129.5CYP2C9, F2, F9, CYP2A6, TTF2, MCFD2

GO Terms for genes affiliated with Warfarin Resistance

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Biological processes related to Warfarin Resistance according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1exogenous drug catabolic processGO:0427389.8CYP2A6, CYP2C9
2steroid metabolic processGO:0082029.8CYP2C9, CYP2A6
3drug metabolic processGO:0171449.5CYP2A6, CYP2C9, VKORC1
4peptidyl-glutamic acid carboxylationGO:0171879.3VKORC1, F9, F2
5blood coagulation, intrinsic pathwayGO:0075979.1F9, F2
6post-translational protein modificationGO:0436878.7VKORC1, MCFD2, F9, F2
7cellular protein metabolic processGO:0442678.6VKORC1, MCFD2, F9, F2

Molecular functions related to Warfarin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.3ALB, CYP2C9

Products for genes affiliated with Warfarin Resistance

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Sources for Warfarin Resistance

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet