MCID: WRF001
MIFTS: 42

Warfarin Resistance malady

Genetic diseases (common) category
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Summaries for Warfarin Resistance

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MalaCards based summary: Warfarin Resistance is related to thromboembolism and factor v deficiency. An important gene associated with Warfarin Resistance is VKORC1 (vitamin K epoxide reductase complex, subunit 1), and among its related pathways are Retinol metabolism and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The compounds sparteine and thiophene have been mentioned in the context of this disorder. Affiliated tissues include liver.

Description from OMIM:46 122700

Aliases & Classifications for Warfarin Resistance

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Warfarin Resistance, Aliases & Descriptions:

Name: Warfarin Resistance 46 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Warfarin Resistance

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Diseases related to Warfarin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism29.8F2, F9, CYP2C9, TTF2
2factor v deficiency10.5F2
3dysfibrinogenemia10.5F2
4hypersplenism10.4F2
5coumarin resistance10.4CYP2A6
6vitamin k deficiency hemorrhagic disease10.3F2, VKORC1
7factor xii deficiency10.3F9
8esophageal varix10.2F2, ALB
9acute liver failure10.2F2, ALB
10hepatorenal syndrome10.2F2, ALB
11short bowel syndrome10.2
12varicose veins10.2F2, ALB
13autoimmune hepatitis10.2F2, CYP2C9
14rickets10.2ALB, CASR
15alcoholic hepatitis10.2F2, ALB
16hepatic encephalopathy10.2F2, ALB
17portal hypertension10.2F2, ALB
18bilirubin metabolic disorder10.2ALB, F2
19hepatitis b10.2ALB, F2
20secondary hyperparathyroidism of renal origin10.2ALB, CASR
21warfarin sensitivity10.1CYP2C9, F9
22leukopenia10.1ALB, F2
23galactosemia10.1ALB, F2
24hyperparathyroidism10.1CASR, ALB
25peritonitis10.1F2, ALB
26factor x deficiency10.1F9, F2
27factor xi deficiency10.1F9, F2
28hemorrhagic disease10.1F2, F9
29von willebrand's disease10.1F2, F9
30factor vii deficiency10.1F2, F9
31factor viii deficiency10.1F9, F2
32bernard-soulier syndrome10.1F2, F9
33protein c deficiency10.1F9, F2
34brain disease10.1F2, TTF2, ALB
35hemophilia b10.1F9, F2
36myocardial infarction10.1
37priapism10.1
38viral hepatitis10.0F2, CYP2A6
39thrombophilia10.0F2, F9
40cork-handlers' disease10.0ALB, F2
41disseminated intravascular coagulation10.0F2, F9
42hypoparathyroidism10.0F9, CASR
43alcoholic liver cirrhosis10.0ALB, CYP2A6, F2
44uremia10.0CASR, ALB
45liver cirrhosis10.0F2, CYP2A6, ALB
46venous thrombosis9.9F2, F9
47pulmonary embolism9.9F2, F9, ALB
48hyperhomocysteinemia9.9ALB, F9, F2
49hypercalcemia9.9ALB, CASR
50thrombocytopenia9.9F2, F9, ALB

Graphical network of the top 20 diseases related to Warfarin Resistance:



Diseases related to warfarin resistance

Symptoms for Warfarin Resistance

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Clinical features from OMIM:

122700

Drugs & Therapeutics for Warfarin Resistance

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Drug clinical trials:

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Genetic Tests for Warfarin Resistance

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Anatomical Context for Warfarin Resistance

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MalaCards organs/tissues related to Warfarin Resistance:

32
Liver

Animal Models for Warfarin Resistance or affiliated genes

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Publications for Warfarin Resistance

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Articles related to Warfarin Resistance:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
C3435T polymorphism of MDR1 gene with warfarin resistance. (23872171)
2013
2
A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay. (23452238)
2013
3
Warfarin resistance associated with parenteral nutrition. (22143126)
2012
4
An instructive case suggesting warfarin resistance which is independent on the regulation of the CYP2C9 and VKORC1 genotype. (22338910)
2011
5
Warfarin resistance induced by oxcarbamazepine. (19666450)
2009
6
An algorithm for managing warfarin resistance. (19952297)
2009
7
Assaying of warfarin in Iranian warfarin resistance patients blood by HPLC. (18817151)
2008
8
Azathioprine-induced warfarin resistance. (18505911)
2008
9
VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals. (18362220)
2008
10
Warfarin resistance. (18776969)
2008
11
Inherited warfarin resistance in Indian patients: does it occur? (17636200)
2007
12
A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance. (17110455)
2007
13
Inherited warfarin resistance in Indian patients: does it occur? (17911202)
2007
14
Warfarin resistance: interaction between warfarin and Eruca sativa L. (16741856)
2006
15
Warfarin resistance in a French strain of rats. (16421894)
2005
16
Warfarin resistance in a patient with mechanical valve prosthesis. (15770320)
2005
17
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (14765194)
2004
18
Warfarin resistance and enteral feedings: 2 case reports and a supporting in vitro study. (11552202)
2001
19
A molecular mechanism for genetic warfarin resistance in the rat. (11641264)
2001
20
Genomic assignment of the warfarin resistance locus, Rw, in the rat. (10384042)
1999
21
Warfarin resistance in a patient with short bowel syndrome. (9620117)
1998
22
Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant-associated priapism. (9803981)
1998
23
Warfarin resistance induced by teicoplanin. (9407741)
1997
24
Warfarin resistance: diagnosis and therapeutic alternatives. (8947972)
1996
25
Hereditary warfarin resistance. (8134868)
1994
26
Warfarin resistance due to malabsorption. (7931050)
1994
27
Warfarin resistance and enteral feedings. (2496251)
1989
28
Warfarin resistance: biochemical evaluation of a warfarin-resistant wild brown rat. (2783170)
1989
29
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987
30
Warfarin resistance associated with intravenous lipid administration. (3110450)
1987
31
Familial warfarin resistance in a black child. (3799934)
1986
32
Warfarin resistance linked to enteral nutrition products. (3998343)
1985
33
Fuzzy: a genetic marker for warfarin resistance in the Norway rat. (3889495)
1985
34
Myocardial infarction after diet-induced warfarin resistance. (6486994)
1984
35
Warfarin resistance with nafcillin therapy. (6703546)
1984
36
Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. (6726460)
1984
37
Multiple allelism at the locus controlling warfarin resistance in the Norway rat. (7141222)
1982
38
Warfarin resistance caused by vitamin K in intestinal feeds. (6815440)
1982
39
Liquid nutrition as a cause of warfarin resistance. (7270565)
1981
40
Relative fitness of genotypes in a population of Rattus norvegicus polymorphic for warfarin resistance. (295047)
1979
41
Warfarin-resistance genotype determination in the Norway rat, Rattus norvegicus. (553191)
1979
42
Genetics of warfarin-resistance in house mice of three separate localities. (621381)
1978
43
Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark. (892442)
1977
44
A major gene controlling warfarin-resistance in the house mouse. (1063212)
1976
45
Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K 1 . (4699235)
1973
46
Warfarin resistance and vitamin K requirement in the rat. (4712304)
1973
47
The biochemistry of warfarin resistance in the rat. (5472172)
1970
48
The warfarin resistance problem in England and Wales. (5293926)
1969
49
Warfarin-resistance in the Netherlands. (5293930)
1969
50
Warfarin resistance in the rat. (5671000)
1968

Variations for Warfarin Resistance

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UniProtKB/Swiss-Prot genetic disease variations for Warfarin Resistance:

64 (show all 18)
id Symbol AA change Variation ID SNP ID
1VKORC1p.Val29LeuVAR_021821rs104894539
2VKORC1p.Val45AlaVAR_021822rs104894540
3VKORC1p.Arg58GlyVAR_021823rs104894541
4VKORC1p.Leu128ArgVAR_021825rs104894542
5VKORC1p.Ala26ThrVAR_065785
6VKORC1p.Asp36GlyVAR_065786
7VKORC1p.Asp36TyrVAR_065787
8VKORC1p.Ser52TrpVAR_065788
9VKORC1p.Ser56PheVAR_065789
10VKORC1p.Trp59CysVAR_065790
11VKORC1p.Trp59LeuVAR_065791
12VKORC1p.Val66GlyVAR_065792
13VKORC1p.Val66MetVAR_065793rs72547529
14VKORC1p.Gly71AlaVAR_065794
15VKORC1p.Asn77SerVAR_065795
16VKORC1p.Asn77TyrVAR_065796
17VKORC1p.Ile123AsnVAR_065797
18VKORC1p.Tyr139HisVAR_065798

Clinvar genetic disease variations for Warfarin Resistance:

6 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1F9F9, ALA-10THRsingle nucleotide variantPathogenic
2F9F9, ALA-10VALundetermined variantPathogenic
3CYP2A6NM_000762.5(CYP2A6): c.479T> A (p.Leu160His)single nucleotide variantPathogenicrs1801272GRCh37Chr 19, 41354533: 41354533
4CYP2A6CYP2A6*12AdeletionPathogenic
5VKORC1NM_024006.4(VKORC1): c.85G> T (p.Val29Leu)single nucleotide variantPathogenicrs104894539GRCh37Chr 16, 31105966: 31105966
6VKORC1NM_024006.4(VKORC1): c.134T> C (p.Val45Ala)single nucleotide variantPathogenicrs104894540GRCh37Chr 16, 31105917: 31105917
7VKORC1NM_024006.4(VKORC1): c.172A> G (p.Arg58Gly)single nucleotide variantPathogenicrs104894541GRCh37Chr 16, 31105879: 31105879
8VKORC1NM_024006.4(VKORC1): c.383T> G (p.Leu128Arg)single nucleotide variantPathogenicrs104894542GRCh37Chr 16, 31102564: 31102564
9VKORC1NM_024006.4(VKORC1): c.-1639G> Asingle nucleotide variantdrug responsers9923231GRCh37Chr 16, 31107689: 31107689
10VKORC1NM_024006.4(VKORC1): c.106G> T (p.Asp36Tyr)single nucleotide variantPathogenicrs61742245GRCh37Chr 16, 31105945: 31105945
11VKORC1NM_024006.4(VKORC1): c.174-136C> Tsingle nucleotide variantdrug responsers9934438GRCh37Chr 16, 31104878: 31104878
12NM_024006.4(VKORC1): c.-1588dupGduplicationdrug responsers397509427GRCh37Chr 16, 31107637: 31107638
13CYP2C9NM_000771.3(CYP2C9): c.1075A> C (p.Ile359Leu)single nucleotide variantdrug responsers1057910GRCh37Chr 10, 96741053: 96741053
14CYP2C9NM_000771.3(CYP2C9): c.430C> T (p.Arg144Cys)single nucleotide variantconfers sensitivityrs1799853GRCh37Chr 10, 96702047: 96702047
15CYP2C9NM_000771.3(CYP2C9): c.622T> G (p.Leu208Val)single nucleotide variantPathogenicrs72558191GRCh37Chr 10, 96707676: 96707676

Expression for genes affiliated with Warfarin Resistance

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Expression patterns in normal tissues for genes affiliated with Warfarin Resistance

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Pathways for genes affiliated with Warfarin Resistance

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Pathways related to Warfarin Resistance according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Retinol metabolism60
9.8CYP2A6, CYP2C9
29.8CYP2A6, CYP2C9
39.8CYP2C9, CYP2A6
49.8CYP2C9, CYP2A6
5
Show member pathways
9.8CYP2C9, CYP2A6
6
Show member pathways
9.5F9, F2
79.3ALB, F9
8
Show member pathways
9.2VKORC1, F9, F2
99.0ALB, F2
10
Show member pathways
8.7F2, F9, MCFD2, VKORC1

Compounds for genes affiliated with Warfarin Resistance

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Compounds related to Warfarin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 217)
idCompoundScoreTop Affiliating Genes
1sparteine44 1111.1CYP2C9, CYP2A6
2thiophene4410.0CYP2C9, CYP2A6
3tienilic acid4410.0CYP2A6, CYP2C9
4vortioxetine5010.0CYP2A6, CYP2C9
5fluindione50 4410.9F2, VKORC1
6mononine449.9F9, F2
7epoxide449.9VKORC1, CYP2A6, CYP2C9
8vitamin k epoxide449.7VKORC1, CYP2C9, F2
9r-warfarin449.6F2, CYP2A6, VKORC1
10sulfisoxazole44 50 61 1112.6ALB, CYP2C9
11rifampicin44 28 6111.6TTF2, CYP2C9, CYP2A6
12s-warfarin449.6CYP2C9, CYP2A6, F2
13gamma-carboxyglutamic acid449.6F9, F2, VKORC1
14sevelamer449.6ALB, CASR
15lidocaine44 28 1111.6CYP2A6, F2, CYP2C9
16organon449.5F2, F9
17ximelagatran44 1110.5CYP2C9, F2
18cefotetan44 1110.4ALB, F2
19nortriptyline50 44 28 1112.4CYP2A6, CYP2C9, ALB
20amlodipine44 50 24 1112.4CYP2A6, CYP2C9, ALB
21fluorouracil50 1110.4CYP2A6, CYP2C9, ALB
22kaolin449.4F2, F9
23propofol44 50 1111.4CYP2A6, CYP2C9, ALB
24diazepam44 28 50 1112.4CYP2A6, CYP2C9, ALB
25halothane44 50 28 1112.3ALB, CYP2C9, CYP2A6
26phenytoin44 50 28 1112.3CYP2A6, CYP2C9, ALB
27dextran 70449.3ALB, F2
28terlipressin44 1110.3ALB, F2
29hepaplastin449.3ALB, F2
30zidovudine44 50 1111.3ALB, CYP2C9, CYP2A6
31acetaminophen44 2 50 24 1113.2CYP2C9, CYP2A6, F9, F2
32dextran449.2TTF2, ALB, F9
33cefoperazone44 1110.1F2, ALB
34phenylbutazone44 1110.1CYP2C9, ALB, F2
35kininogen449.0F2, F9, ALB
36tween 80449.0ALB, F9
37coumarins449.0VKORC1, CYP2C9, CYP2A6, F9, F2
38coumarin44 2 50 2412.0CYP2A6, F9, F2, CYP2C9, VKORC1
39diclofenac44 28 50 1111.9CYP2A6, CYP2C9, TTF2, ALB
40antipyrine44 119.8F2, CYP2A6, CYP2C9, ALB
41menadione44 24 1110.8VKORC1L1, VKORC1, CYP2A6, F2, F9
42cyclosporin a44 28 6110.6CASR, F9, F2, TTF2, CYP2C9
43acenocoumarol44 50 1110.5ALB, F2, F9, CYP2C9, VKORC1
44phenprocoumon44 50 1110.5F2, CYP2C9, F9, VKORC1, ALB
45fibrinogen448.5F9, TTF2, F2, ALB
46cysteine448.2F9, ALB, TTF2, VKORC1, CASR
47creatinine448.1CASR, ALB, TTF2, F9, F2
48alanine448.0TTF2, CASR, ALB, F9, F2
49glucose448.0ALB, CASR, CYP2C9, F9, TTF2
50warfarin44 50 24 119.6CYP2A6, F2, F9, CYP2C9, TTF2, MCFD2

GO Terms for genes affiliated with Warfarin Resistance

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Biological processes related to Warfarin Resistance according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1exogenous drug catabolic processGO:0427389.8CYP2A6, CYP2C9
2steroid metabolic processGO:0082029.8CYP2C9, CYP2A6
3drug metabolic processGO:0171449.6CYP2A6, CYP2C9, VKORC1
4peptidyl-glutamic acid carboxylationGO:0171879.3VKORC1, F9, F2
5blood coagulation, intrinsic pathwayGO:0075979.2F9, F2
6post-translational protein modificationGO:0436878.8VKORC1, MCFD2, F9, F2
7cellular protein metabolic processGO:0442678.6VKORC1, MCFD2, F9, F2

Products for genes affiliated with Warfarin Resistance

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Sources for Warfarin Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet