MCID: WRF001
MIFTS: 31

Warfarin Resistance malady

Summaries for Warfarin Resistance

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46OMIM, 32MalaCards
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MalaCards: Warfarin Resistance, also known as coumarin resistance, is related to coumarin resistance and short bowel syndrome. An important gene associated with Warfarin Resistance is VKORC1 (vitamin K epoxide reductase complex, subunit 1), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Naphthalene metabolism. The compounds Dicumarol and fluindione have been mentioned in the context of this disorder.

Description from OMIM:46 122700

Aliases & Classifications for Warfarin Resistance

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46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

warfarin resistance 46 44
coumarin resistance 60


Related Diseases for Warfarin Resistance

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17GeneCards, 18GeneDecks
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Diseases related to Warfarin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1coumarin resistance30.4CYP2A6
2short bowel syndrome30.2ALB
3myocardial infarction30.0CYP2C9
4priapism10.0
5factor viii deficiency10.0MCFD2
6dementia10.0TTF2
7diabetes mellitus10.0ALB
8warfarin sensitivity10.0CYP2C9
9diarrhea10.0ALB
10skin disease10.0ALB
11ischemia10.0CYP2A6
12portal vein thrombosis10.0F2
13antiphospholipid syndrome10.0F2
14coronary heart disease10.0TTF2, VKORC1
15factor v deficiency10.0F2
16peripheral vascular disease10.0ALB
17hypersplenism10.0F2
18dysfibrinogenemia10.0F2
19obesity10.0CYP2A6, TTF2
20vitamin k deficiency hemorrhagic disease10.0VKORC1, F2
21viral hepatitis10.0CYP2A6, F2
22pulmonary embolism10.0F2, ALB
23esophageal varix10.0F2, ALB
24stroke, ischemic10.0F2, ALB
25acute liver failure10.0ALB, F2
26hepatorenal syndrome10.0ALB, F2
27alcoholic hepatitis10.0ALB, F2
28portal hypertension10.0ALB, F2
29cholestasis10.0ALB, F2
30bilirubin metabolic disorder10.0ALB, F2
31autoimmune hepatitis10.0F2, CYP2C9
32hepatic encephalopathy10.0F2, ALB
33hepatitis b10.0ALB, F2
34chronic kidney failure10.0CYP2C9, TTF2, ALB
35galactosemia10.0F2, ALB
36alcoholic liver cirrhosis10.0CYP2A6, F2, ALB
37factor v leiden thrombophilia10.0F2, CYP2C9, VKORC1
38thromboembolism10.0F2, CYP2C9, TTF2
39brain disease10.0F2, TTF2, ALB
40varicose veins10.0F2, ALB
41sepsis10.0ALB, F2, TTF2
42cork-handlers' disease10.0ALB, F2
43hepatocellular carcinoma10.0ALB, F2, CYP2A6
44cadasil10.0F2, VKORC1, CYP2C9, TTF2
45liver cirrhosis10.0F2, CYP2A6, ALB
46deficiency anemia10.0TTF2, F2, ALB
47hepatitis10.0CYP2A6, CYP2C9, TTF2, F2

Graphical network of the top 20 diseases related to Warfarin Resistance:



Diseases related to warfarin resistance

Clinical Features for Warfarin Resistance

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46OMIM
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Clinical features from OMIM:

122700

Drugs & Therapeutics for Warfarin Resistance

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Warfarin Resistance

Drug clinical trials:

Search ClinicalTrials for Warfarin Resistance

Search NIH Clinical Center for Warfarin Resistance

Search CenterWatch for Warfarin Resistance

Genetic Tests for Warfarin Resistance

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Anatomical Context for Warfarin Resistance

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Animal Models for Warfarin Resistance or affiliated genes

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Publications for Warfarin Resistance

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Genetic Variations for Warfarin Resistance

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Warfarin Resistance:

62 (show all 18)
id Symbol AA change Variation ID SNP ID
1VKORC1p.Val29LeuVAR_021821rs104894539
2VKORC1p.Val45AlaVAR_021822rs104894540
3VKORC1p.Arg58GlyVAR_021823rs104894541
4VKORC1p.Leu128ArgVAR_021825rs104894542
5VKORC1p.Ala26ThrVAR_065785
6VKORC1p.Asp36GlyVAR_065786
7VKORC1p.Asp36TyrVAR_065787
8VKORC1p.Ser52TrpVAR_065788
9VKORC1p.Ser56PheVAR_065789
10VKORC1p.Trp59CysVAR_065790
11VKORC1p.Trp59LeuVAR_065791
12VKORC1p.Val66GlyVAR_065792
13VKORC1p.Val66MetVAR_065793rs72547529
14VKORC1p.Gly71AlaVAR_065794
15VKORC1p.Asn77SerVAR_065795
16VKORC1p.Asn77TyrVAR_065796
17VKORC1p.Ile123AsnVAR_065797
18VKORC1p.Tyr139HisVAR_065798

Expression for genes affiliated with Warfarin Resistance

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Warfarin Resistance

Search GEO for disease gene expression data for Warfarin Resistance.

Pathways for genes affiliated with Warfarin Resistance

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Sources:
49PharmGKB, 12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Warfarin Resistance

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Sources:
11DrugBank, 44Novoseek, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Warfarin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1Dicumarol1110.0CYP2C9, VKORC1
2fluindione44 4910.9VKORC1, F2
3Arformoterol119.9CYP2A6, CYP2C9
4sparteine44 1110.9CYP2A6, CYP2C9
5thiophene449.9CYP2A6, CYP2C9
6tienilic acid449.9CYP2A6, CYP2C9
7Dexfenfluramine119.8CYP2C9, CYP2A6
8vitamin k144 2410.7F2, VKORC1
9epoxide449.6CYP2A6, CYP2C9, VKORC1
10ximelagatran44 1110.6F2, CYP2C9
117-ethoxy-4-trifluoromethylcoumarin449.5CYP2A6, CYP2C9
12Sulfamethizole119.5ALB, CYP2C9
13r-warfarin449.5VKORC1, CYP2A6, F2
14sulfisoxazole44 59 49 1112.5ALB, CYP2C9
15rifampicin44 28 5911.5TTF2, CYP2C9, CYP2A6
16furafylline449.4CYP2A6, CYP2C9
17cefotetan44 1110.4F2, ALB
18vitamin k epoxide449.4F2, CYP2C9, VKORC1
19Estropipate119.4ALB, CYP2C9
20dextran 70449.4F2, ALB
21s-warfarin449.4F2, CYP2A6, CYP2C9
22hepaplastin449.3ALB, F2
23lidocaine44 28 1111.3CYP2A6, CYP2C9, F2
24terlipressin44 1110.3ALB, F2
25alfentanil44 1110.3CYP2A6, ALB
26cefoperazone44 1110.3F2, ALB
27Vismodegib119.3CYP2C9, ALB
28acetaminophen44 2 49 11 2413.3CYP2C9, CYP2A6, F2
29fosphenytoin44 1110.2ALB, CYP2C9
30nortriptyline44 49 28 1112.1ALB, CYP2C9, CYP2A6
31fluorouracil49 1110.1CYP2A6, ALB, CYP2C9
32amlodipine44 49 11 2412.1CYP2C9, CYP2A6, ALB
33Enzalutamide 119.1CYP2C9, ALB
34propofol44 49 1111.1ALB, CYP2A6, CYP2C9
35diazepam44 49 28 1112.1ALB, CYP2A6, CYP2C9
36phenytoin44 49 28 1112.1ALB, CYP2A6, CYP2C9
37halothane44 28 1111.1CYP2A6, CYP2C9, ALB
38zidovudine44 1110.1CYP2C9, ALB, CYP2A6
39coumarins449.0VKORC1, CYP2C9, CYP2A6, F2
40coumarin44 2 49 2412.0VKORC1, F2, CYP2C9, CYP2A6
41menadione44 11 2411.0F2, CYP2A6, VKORC1L1, VKORC1
42valproic acid44 49 11 2411.9ALB, CYP2C9, CYP2A6
43phenylbutazone44 119.9CYP2C9, ALB, F2
44estrone44 28 11 2411.9ALB, CYP2C9, CYP2A6
45prasugrel44 49 1110.8ALB, CYP2C9
46diclofenac44 28 49 1111.7ALB, TTF2, CYP2A6, CYP2C9
47acenocoumarol44 49 1110.6CYP2C9, ALB, F2, VKORC1
48phenprocoumon44 49 1110.6ALB, F2, CYP2C9, VKORC1
49antipyrine44 119.5CYP2C9, CYP2A6, F2, ALB
50warfarin44 49 11 249.9CYP2C9, TTF2, F2, MCFD2, CYP2A6, VKORC1L1

GO Terms for genes affiliated with Warfarin Resistance

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16Gene Ontology
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Biological processes related to Warfarin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exogenous drug catabolic processGO:0427389.4CYP2C9, CYP2A6
2peptidyl-glutamic acid carboxylationGO:0171879.2VKORC1, F2
3drug metabolic processGO:0171449.2CYP2A6, CYP2C9, VKORC1
4post-translational protein modificationGO:0436879.1F2, MCFD2, VKORC1

Products for genes affiliated with Warfarin Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Warfarin Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet