MCID: WRF001
MIFTS: 39

Warfarin Resistance malady

Genetic diseases (common) category

Summaries for Warfarin Resistance

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48OMIM, 34MalaCards
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MalaCards: Warfarin Resistance, also known as coumarin resistance, is related to thromboembolism and short bowel syndrome. An important gene associated with Warfarin Resistance is VKORC1 (vitamin K epoxide reductase complex, subunit 1), and among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. The compounds fluindione and r-warfarin have been mentioned in the context of this disorder. Affiliated tissues include liver.

Description from OMIM:48 122700

Aliases & Classifications for Warfarin Resistance

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Sources:
48OMIM, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

warfarin resistance 48 46
coumarin resistance 63


Related Diseases for Warfarin Resistance

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18GeneCards, 19GeneDecks
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Diseases related to Warfarin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism30.0F2, CYP2C9, TTF2
2short bowel syndrome10.2
3factor viii deficiency10.1MCFD2
4warfarin sensitivity10.1CYP2C9
5dysfibrinogenemia10.1F2
6hypersplenism10.1F2
7priapism10.1
8myocardial infarction10.1
9vitamin k deficiency hemorrhagic disease10.0VKORC1, F2
10esophageal varix10.0ALB, F2
11acute liver failure10.0ALB, F2
12varicose veins10.0F2, ALB
13hepatorenal syndrome10.0ALB, F2
14portal hypertension10.0F2, ALB
15hepatic encephalopathy10.0ALB, F2
16alcoholic hepatitis10.0ALB, F2
17pulmonary embolism10.0ALB, F2
18bilirubin metabolic disorder10.0F2, ALB
19alcoholic liver cirrhosis10.0F2, ALB
20hepatitis b10.0ALB, F2
21leukopenia10.0ALB, F2
22peritonitis10.0ALB, F2
23hyperhomocysteinemia10.0F2, ALB
24cork-handlers' disease10.0F2, ALB
25hepatitis10.0ALB, F2
26autoimmune hepatitis10.0CYP2C9, F2
27connective tissue disease10.0F2, ALB
28cholestasis10.0F2, ALB
29stroke, ischemic10.0ALB, F2
30primary hyperoxaluria10.0ALB, F2
31primary biliary cirrhosis10.0ALB, F2
32chronic kidney failure10.0CYP2C9, TTF2, ALB
33vasculitis10.0ALB, F2
34thrombocytopenia10.0F2, ALB
35factor v leiden thrombophilia10.0VKORC1, F2, CYP2C9
36brain disease10.0ALB, TTF2, F2
37galactosemia10.0ALB, F2
38liver cirrhosis10.0ALB, TTF2, F2
39deficiency anemia10.0TTF2, F2, ALB
40sepsis10.0ALB, F2, TTF2
41congenital heart disease9.9ALB, F2
42cerebrovascular disease9.9CYP2C9, F2, TTF2, VKORC1

Graphical network of the top 20 diseases related to Warfarin Resistance:



Diseases related to warfarin resistance

Symptoms for Warfarin Resistance

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Sources:
48OMIM
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Clinical features from OMIM:

122700

Drugs & Therapeutics for Warfarin Resistance

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Warfarin Resistance

Drug clinical trials:

Search ClinicalTrials for Warfarin Resistance

Search NIH Clinical Center for Warfarin Resistance

Search CenterWatch for Warfarin Resistance

Genetic Tests for Warfarin Resistance

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Anatomical Context for Warfarin Resistance

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34MalaCards
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MalaCards organs/tissues related to Warfarin Resistance:

34
Liver

Animal Models for Warfarin Resistance or affiliated genes

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Publications for Warfarin Resistance

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Sources:
53PubMed
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Articles related to Warfarin Resistance:

(show top 50)    (show all 87)
idTitleAuthorsYear
1
C3435T polymorphism of MDR1 gene with warfarin resistance. (23872171)
2013
2
A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay. (23452238)
2013
3
Warfarin resistance associated with parenteral nutrition. (22143126)
2012
4
An instructive case suggesting warfarin resistance which is independent on the regulation of the CYP2C9 and VKORC1 genotype. (22338910)
2011
5
Warfarin resistance induced by oxcarbamazepine. (19666450)
2009
6
An algorithm for managing warfarin resistance. (19952297)
2009
7
Assaying of warfarin in Iranian warfarin resistance patients blood by HPLC. (18817151)
2008
8
Azathioprine-induced warfarin resistance. (18505911)
2008
9
VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals. (18362220)
2008
10
Warfarin resistance. (18776969)
2008
11
Vitamin K-independent warfarin resistance after concurrent administration of warfarin and continuous enteral nutrition. (18294110)
2008
12
Inherited warfarin resistance in Indian patients: does it occur? (17636200)
2007
13
A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance. (17110455)
2007
14
Inherited warfarin resistance in Indian patients: does it occur? (17911202)
2007
15
Warfarin resistance: interaction between warfarin and Eruca sativa L. (16741856)
2006
16
Warfarin resistance in a French strain of rats. (16421894)
2005
17
Warfarin resistance in a patient with mechanical valve prosthesis. (15770320)
2005
18
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (14765194)
2004
19
A molecular mechanism for genetic warfarin resistance in the rat. (11641264)
2001
20
Genomic assignment of the warfarin resistance locus, Rw, in the rat. (10384042)
1999
21
Warfarin resistance in a patient with short bowel syndrome. (9620117)
1998
22
Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant-associated priapism. (9803981)
1998
23
Warfarin resistance induced by teicoplanin. (9407741)
1997
24
Warfarin resistance: diagnosis and therapeutic alternatives. (8947972)
1996
25
Hereditary warfarin resistance. (8134868)
1994
26
Warfarin resistance due to malabsorption. (7931050)
1994
27
Warfarin resistance and enteral feedings. (2496251)
1989
28
Warfarin resistance: biochemical evaluation of a warfarin-resistant wild brown rat. (2783170)
1989
29
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987
30
Warfarin resistance associated with intravenous lipid administration. (3110450)
1987
31
Familial warfarin resistance in a black child. (3799934)
1986
32
Warfarin resistance linked to enteral nutrition products. (3998343)
1985
33
Fuzzy: a genetic marker for warfarin resistance in the Norway rat. (3889495)
1985
34
Myocardial infarction after diet-induced warfarin resistance. (6486994)
1984
35
Warfarin resistance with nafcillin therapy. (6703546)
1984
36
Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. (6726460)
1984
37
Multiple allelism at the locus controlling warfarin resistance in the Norway rat. (7141222)
1982
38
Warfarin resistance caused by vitamin K in intestinal feeds. (6815440)
1982
39
Liquid nutrition as a cause of warfarin resistance. (7270565)
1981
40
Relative fitness of genotypes in a population of Rattus norvegicus polymorphic for warfarin resistance. (295047)
1979
41
Warfarin-resistance genotype determination in the Norway rat, Rattus norvegicus. (553191)
1979
42
Genetics of warfarin-resistance in house mice of three separate localities. (621381)
1978
43
Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark. (892442)
1977
44
A major gene controlling warfarin-resistance in the house mouse. (1063212)
1976
45
Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K 1 . (4699235)
1973
46
Warfarin resistance and vitamin K requirement in the rat. (4712304)
1973
47
The biochemistry of warfarin resistance in the rat. (5472172)
1970
48
The warfarin resistance problem in England and Wales. (5293926)
1969
49
Warfarin-resistance in the Netherlands. (5293930)
1969
50
Warfarin resistance in the rat. (5671000)
1968

Variations for Warfarin Resistance

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Sources:
65UniProtKB/Swiss-Prot, 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Warfarin Resistance:

65 (show all 18)
id Symbol AA change Variation ID SNP ID
1VKORC1p.Val29LeuVAR_021821rs104894539
2VKORC1p.Val45AlaVAR_021822rs104894540
3VKORC1p.Arg58GlyVAR_021823rs104894541
4VKORC1p.Leu128ArgVAR_021825rs104894542
5VKORC1p.Ala26ThrVAR_065785
6VKORC1p.Asp36GlyVAR_065786
7VKORC1p.Asp36TyrVAR_065787
8VKORC1p.Ser52TrpVAR_065788
9VKORC1p.Ser56PheVAR_065789
10VKORC1p.Trp59CysVAR_065790
11VKORC1p.Trp59LeuVAR_065791
12VKORC1p.Val66GlyVAR_065792
13VKORC1p.Val66MetVAR_065793rs72547529
14VKORC1p.Gly71AlaVAR_065794
15VKORC1p.Asn77SerVAR_065795
16VKORC1p.Asn77TyrVAR_065796
17VKORC1p.Ile123AsnVAR_065797
18VKORC1p.Tyr139HisVAR_065798

Expression for genes affiliated with Warfarin Resistance

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Warfarin Resistance

Search GEO for disease gene expression data for Warfarin Resistance.

Pathways for genes affiliated with Warfarin Resistance

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Sources:
51PathCards, 56Reactome, 52PharmGKB, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Warfarin Resistance according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VKORC1, F2
2
Show member pathways
9.1VKORC1, MCFD2, F2
39.0ALB, F2
4
Show member pathways
thioredoxin pathway39
9.0ALB, F2

Compounds for genes affiliated with Warfarin Resistance

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Sources:
52PharmGKB, 46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Warfarin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1fluindione52 4610.9VKORC1, F2
2r-warfarin469.9VKORC1, F2
3vitamin k146 2510.9VKORC1, F2
4gamma-carboxyglutamic acid469.8F2, VKORC1
5s-warfarin469.7F2, CYP2C9
6methadone52 46 1211.7CYP2C9, TTF2
7ximelagatran46 1210.7CYP2C9, F2
8amiodarone46 52 30 1212.6CYP2C9, F2
9sulfisoxazole46 52 62 1212.6ALB, CYP2C9
10fosphenytoin46 1210.5ALB, CYP2C9
11suprofen46 1210.5ALB, CYP2C9
12prasugrel46 52 1211.5CYP2C9, ALB
13pitavastatin52 1210.5CYP2C9, ALB
14etodolac46 1210.5CYP2C9, ALB
15nateglinide46 52 1211.5ALB, CYP2C9
16diltiazem46 30 52 1212.5CYP2C9, F2
17ketoprofen30 46 1211.5ALB, CYP2C9
18gliclazide46 52 1211.5ALB, CYP2C9
19piroxicam46 1210.5ALB, CYP2C9
20cefotetan46 1210.5F2, ALB
21valsartan46 62 30 1212.5CYP2C9, ALB
22dextran469.5TTF2, ALB
23dextran 70469.5ALB, F2
24terlipressin46 1210.4ALB, F2
25naproxen46 25 1211.4CYP2C9, ALB
26hepaplastin469.4F2, ALB
27flurbiprofen46 30 52 1212.4ALB, CYP2C9
28cefoperazone46 1210.4F2, ALB
29irbesartan46 30 52 1212.4CYP2C9, ALB
30hydroxyethyl starch469.4F2, ALB
31vitamin k epoxide469.4VKORC1, CYP2C9, F2
32sulfamethoxazole52 46 1211.4ALB, CYP2C9
33coumarins469.4VKORC1, F2, CYP2C9
34coumarin46 3 52 2512.4CYP2C9, F2, VKORC1
35menadione46 25 1211.4VKORC1L1, F2, VKORC1
36candesartan46 52 30 1212.3CYP2C9, ALB
37nortriptyline52 46 30 1212.3CYP2C9, ALB
38aspirin46 52 30 2512.2CYP2C9, F2, TTF2
39paroxetine46 52 30 1212.2F2, CYP2C9
40amlodipine46 52 25 1212.2ALB, CYP2C9
41saquinavir46 1210.1CYP2C9, ALB
42rosuvastatin46 52 30 1212.1ALB, CYP2C9
43diclofenac46 30 52 1212.1ALB, TTF2, CYP2C9
44phenylbutazone46 1210.0F2, CYP2C9, ALB
45antipyrine46 129.9ALB, F2, CYP2C9
46fluorouracil52 129.8CYP2C9, ALB
47fibrinogen468.7TTF2, F2, ALB
48acenocoumarol46 52 1210.6CYP2C9, F2, VKORC1, ALB
49phenprocoumon46 52 1210.6ALB, CYP2C9, F2, VKORC1
50warfarin46 52 25 1210.2CYP2C9, F2, TTF2, MCFD2, VKORC1, VKORC1L1

GO Terms for genes affiliated with Warfarin Resistance

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Sources:
17Gene Ontology
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Biological processes related to Warfarin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:0171879.5VKORC1, F2
2drug metabolic processGO:0171449.3VKORC1, CYP2C9
3cellular protein metabolic processGO:0442679.1VKORC1, MCFD2, F2
4post-translational protein modificationGO:0436879.0MCFD2, F2, VKORC1

Molecular functions related to Warfarin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1ALB, CYP2C9

Products for genes affiliated with Warfarin Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Warfarin Resistance

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet