MCID: WRT003
MIFTS: 33

Warthin Tumor malady

Category: Rare diseases

Aliases & Classifications for Warthin Tumor

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Aliases & Descriptions for Warthin Tumor:

Name: Warthin Tumor 48
 
Adenolymphoma 68

Classifications:



Summaries for Warthin Tumor

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NIH Rare Diseases:48 Warthin tumor is a benign tumor of the salivary gland. the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. warthin tumors may increase in size over time, but few become cancerous. though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor. treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 9/8/2015

MalaCards based summary: Warthin Tumor, also known as adenolymphoma, is related to childhood mediastinal neurogenic tumor and conjunctival intraepithelial neoplasm. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cell adhesion_ECM remodeling. Affiliated tissues include salivary gland, lymph node and thyroid, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and reproductive system.

Related Diseases for Warthin Tumor

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Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1childhood mediastinal neurogenic tumor10.3CRTC1, MAML2
2conjunctival intraepithelial neoplasm10.3CRTC1, MAML2
3uterus leiomyosarcoma10.3CD44, KIT
4testis sarcoma10.3KIT, KRT18
5multidrug-resistant tuberculosis10.2CRTC1, KRT18, MAML2
6proteus-like syndrome10.2KRT18, KRT7
7kahrizi syndrome10.2KIT, TGFA
8nonossifying fibromyxoid tumor10.2KIT, KRT7
9lung combined type small cell carcinoma10.1CRTC1, KRT7, MAML2
10paranasal sinus cancer10.1KIT, KRT7
11speech disorder10.1CEACAM5, KIT
12dysembryoplastic neuroepithelial tumor10.1CD44, KRT18, KRT7
13chronic granulomatous disease10.1KIT, KRT18, KRT7
14hypoglossal nerve disease10.1CEACAM5, KIT
15middle ear adenocarcinoma10.1KIT, KRT7
16plasmodium ovale malaria10.0CRTC1, KIT, KRT7, MAML2
17lymphoma10.0
18osteosarcoma arising in bone paget's disease10.0CEACAM5, KRT7
19synovitis10.0CEACAM5, KRT7
20breast adenocarcinoma10.0CEACAM5, KRT7
21laryngeal mucoepidermoid carcinoma10.0CEACAM5, KRT7
22ovarian wilms' cancer10.0CEACAM5, KRT18
23prostate lymphoma10.0CEACAM5, KRT7
24tuberculosis10.0
25mucoepidermoid carcinoma10.0
26thyroiditis10.0
27sclerosing breast papilloma10.0CEACAM5, KRT7
28waterhouse-friderichsen syndrome10.0CEACAM5, KRT7
29main bronchus cancer9.9CEACAM5, KRT7
30trophoblastic neoplasm9.9CEACAM5, KRT7
31precursor t-lymphoblastic lymphoma/leukemia9.9CEACAM5, KIT
32tubular adenocarcinoma9.9CEACAM5, KRT7
33apocrine adenocarcinoma9.9CEACAM5, KRT7
34cervicitis9.9
35cystadenoma9.9
36vulva basal cell carcinoma9.9CEACAM5, KIT, KRT7
37advanced sleep phase syndrome9.9CEACAM5, KIT, KRT7
38bartholin's gland adenoid cystic carcinoma9.9CEACAM5, KRT18, KRT7
39endocrine organ benign neoplasm9.9CEACAM5, KIT, KRT7
40mitochondrial dna depletion syndrome 59.9CEACAM5, KIT, KRT7
41muscular dystrophy-dystroglycanopathy , type b, 29.9CD44, KIT, KRT7, TGFA
42breast granular cell tumor9.8CEACAM5, KRT7
43deep angioma9.8CEACAM5, CRTC1, KRT7, MAML2
44adenocarcinoma9.8
45female breast axillary tail cancer9.8CEACAM5, KRT7
46malignant pleural solitary fibrous tumor9.8CD44, CEACAM5, KIT, KRT7
47proctitis9.8CD44, CEACAM5, KIT, KRT7
48vulvar angiokeratoma9.7CEACAM5, KRT7
49hodgkin lymphoma9.7
50b-cell lymphomas9.7

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms & Phenotypes for Warthin Tumor

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GenomeRNAi Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-8410.2KRT18, KRT7, TGFB2

MGI Mouse Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8CD44, CRTC1, ERBB4, KIT, TGFA, TGFB2
2MP:00053698.7CD44, CRTC3, ERBB4, HBEGF, KIT, TGFA
3MP:00053888.5CD44, ERBB4, HBEGF, KIT, TGFB2, THY1
4MP:00053788.0CD44, CRTC1, CRTC3, HBEGF, KIT, KRT18

Drugs & Therapeutics for Warthin Tumor

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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MalaCards organs/tissues related to Warthin Tumor:

36
Salivary gland, Lymph node, Thyroid, Tongue, B cells, T cells, Lung

Publications for Warthin Tumor

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Articles related to Warthin Tumor:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. (27806841)
2016
2
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. (27438374)
2016
3
Incidental Warthin Tumor on Pertechnetate Scintigraphy. (27405035)
2016
4
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. (28013343)
2016
5
If cytology of Warthin tumor is accurate, can management be conservative? (27140020)
2016
6
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. (26119391)
2015
7
Synchronous parotid and nasopharyngeal Warthin tumor. (26315140)
2015
8
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. (26170867)
2015
9
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. (25992164)
2015
10
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. (26169920)
2015
11
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. (26634829)
2015
12
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. (25816418)
2015
13
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. (25149652)
2014
14
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. (24791853)
2014
15
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (24880872)
2014
16
Erratum to: Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (25190011)
2014
17
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (24565204)
2014
18
Warthin tumor in an unusual site: a case report. (23715204)
2013
19
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
20
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. (23635480)
2013
21
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
22
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. (23868565)
2013
23
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
24
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. (23863526)
2013
25
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
26
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. (22576704)
2012
27
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
28
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
29
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
30
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
31
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
32
Adenocarcinoma arising in warthin tumor of the parotid gland. (23011833)
2012
33
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
34
Warthin tumor arising from the minor salivary gland. (22976673)
2012
35
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
36
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
37
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
38
Brucella melitensis infection within warthin tumor of the parotid gland. (21959459)
2011
39
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. (21493251)
2011
40
Warthin tumor of the upper lip: an unusual location of a benign salivary gland tumor. (19189998)
2011
41
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. (21549478)
2011
42
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
43
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
44
Familial Warthin tumor: occurrence in monozygotic twins. (19944513)
2010
45
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
46
Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases. (19625134)
2010
47
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
48
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
49
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
50
Warthin tumor: a curious entity--case reports and review of literature. (19434322)
2009

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.3CD44, HBEGF, KIT, TGFA, THY1, VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatic stem cell divisionGO:004810310.6KIT, TGFB2
2negative regulation of ERBB signaling pathwayGO:190118510.5ERBB4, HBEGF
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.5ERBB4, KIT
4regulation of cell motilityGO:200014510.5ERBB4, HBEGF
5mammary gland alveolus developmentGO:006074910.4ERBB4, TGFA
6positive regulation of heterotypic cell-cell adhesionGO:003411610.4CD44, THY1
7positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.3ERBB4, KIT, TGFB2
8peptidyl-tyrosine phosphorylationGO:001810810.3ERBB4, HBEGF, KIT
9phosphatidylinositol phosphorylationGO:004685410.3ERBB4, HBEGF, KIT
10cell chemotaxisGO:006032610.2HBEGF, KIT, VCAM1
11phosphatidylinositol-mediated signalingGO:004801510.2ERBB4, HBEGF, KIT
12signal transduction by protein phosphorylationGO:002301410.2ERBB4, KIT, TGFB2
13energy homeostasisGO:009700910.2CRTC1, CRTC3
14regulation of phosphatidylinositol 3-kinase signalingGO:001406610.2ERBB4, HBEGF, KIT
15positive regulation of CREB transcription factor activityGO:003279310.1CRTC1, CRTC3
16positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1CD44, HBEGF, TGFA
17single organismal cell-cell adhesionGO:001633710.0CD44, THY1, VCAM1
18positive regulation of cell proliferationGO:00082849.5ERBB4, HBEGF, KIT, TGFA, TGFB2
19negative regulation of apoptotic processGO:00430669.0CD44, CEACAM5, ERBB4, KRT18, TGFA
20viral processGO:00160328.2CRTC1, CRTC3, KRT18, KRT7, VCAM1

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.1ERBB4, HBEGF, KIT
2cAMP response element binding protein bindingGO:000814010.1CRTC1, CRTC3
3protein tyrosine kinase activityGO:000471310.1ERBB4, HBEGF, KIT
4growth factor activityGO:000808310.1HBEGF, TGFA, TGFB2
5epidermal growth factor receptor bindingGO:000515410.0ERBB4, HBEGF, TGFA
6signal transducer, downstream of receptor, with protein tyrosine kinase activityGO:00047169.8ERBB4, KIT
7GPI anchor bindingGO:00342359.8CEACAM5, THY1
8Ras guanyl-nucleotide exchange factor activityGO:00050889.7ERBB4, HBEGF, KIT

Sources for Warthin Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet