MCID: WRT003
MIFTS: 26

Warthin Tumor malady

Rare diseases, Immune diseases, Cancer diseases categories

Aliases & Classifications for Warthin Tumor

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Warthin Tumor, Aliases & Descriptions:

Name: Warthin Tumor 41
Papillary Cystadenoma Lymphomatosum 41
 
Adenolymphoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Summaries for Warthin Tumor

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NIH Rare Diseases:41 Warthin tumor is an unusual growth of cells (tumor) in a salivary gland.  the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin.  warthin tumors may increase in size over time, but few become cancerous.  though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor.  treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 10/10/2012

MalaCards based summary: Warthin Tumor, also known as papillary cystadenoma lymphomatosum, is related to necrotizing sialometaplasia and mucoepidermoid carcinoma. An important gene associated with Warthin Tumor is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are HTLV-I infection and Glucose / Energy Metabolism. Affiliated tissues include salivary gland, lymph node and thyroid, and related mouse phenotype adipose tissue.

Related Diseases for Warthin Tumor

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Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms for Warthin Tumor

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Drugs & Therapeutics for Warthin Tumor

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Drug clinical trials:

Search ClinicalTrials for Warthin Tumor

Search NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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MalaCards organs/tissues related to Warthin Tumor:

31
Salivary gland, Lymph node, Thyroid, Lung, T cells, Tongue

Animal Models for Warthin Tumor or affiliated genes

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MGI Mouse Phenotypes related to Warthin Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8NOS2, CRTC1, CRTC3

Publications for Warthin Tumor

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Articles related to Warthin Tumor:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. (25816418)
2015
2
Erratum to: Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (25190011)
2014
3
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. (24791853)
2014
4
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (24565204)
2014
5
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. (25149652)
2014
6
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (24880872)
2014
7
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
8
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
9
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
10
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
11
Warthin tumor in an unusual site: a case report. (23715204)
2013
12
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. (23868565)
2013
13
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
14
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
15
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
16
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
17
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
18
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
19
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. (22576704)
2012
20
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
21
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
22
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
23
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. (21549478)
2011
24
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
25
Brucella melitensis infection within warthin tumor of the parotid gland. (21959459)
2011
26
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
27
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
28
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
29
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
30
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
31
Warthin tumor: a curious entity--case reports and review of literature. (19434322)
2009
32
Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. (19031731)
2008
33
Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. (15994480)
2005
34
Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. (16000851)
2005
35
Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate. (16012309)
2005
36
Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation. (15313720)
2004
37
Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. (12811857)
2003
38
False diagnosis caused by Warthin tumor of the parotid gland combined with actinomycosis. (12544220)
2003
39
Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature. (11026102)
2000
40
Follicle center lymphoma and Warthin tumor involving the same anatomic site. Report of two cases and review of the literature. (10631864)
2000
41
Quiz case 2. Warthin tumor. (10555703)
1999
42
Warthin tumor. A new hypothesis concerning its development. (9474616)
1998
43
Molecular characterization of Warthin tumor. (9619676)
1998
44
An unusual neck mass: the Warthin tumor. (9581198)
1998
45
Warthin tumor of the lacrimal gland. (9402842)
1997
46
Aspiration cytology features of the warthin tumor-like variant of papillary thyroid carcinoma. A report of two cases. (9990276)
1997
47
Warthin tumor of the parotid gland: MR-pathologic correlation. (8427092)
1993
48
Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. (7281493)
1981
49
Letter: Warthin tumor in two brothers. (988997)
1976
50
Papillary cystadenoma lymphomatosum (Warthin tumor). (5639487)
1968

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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Pathways related to Warthin Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CRTC1, CRTC3
29.3CRTC1, CRTC3

Compounds for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056348.0NOS2, CRTC1, CRTC3, MAML2

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homotetramerizationGO:00512899.3CRTC1, CRTC3
2positive regulation of CREB transcription factor activityGO:00327939.0CRTC1, CRTC3

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cAMP response element binding protein bindingGO:00081409.3CRTC1, CRTC3

Products for genes affiliated with Warthin Tumor

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Sources for Warthin Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet