MCID: WRT003
MIFTS: 36

Warthin Tumor malady

Categories: Rare diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Warthin Tumor

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Aliases & Descriptions for Warthin Tumor:

Name: Warthin Tumor 45
Papillary Cystadenoma Lymphomatosum 45
 
Adenolymphoma 65

Classifications:



External Ids:

UMLS65 C0001429

Summaries for Warthin Tumor

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NIH Rare Diseases:45 Warthin tumor is a benign tumor of the salivary gland. the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. warthin tumors may increase in size over time, but few become cancerous. though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor. treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 9/8/2015

MalaCards based summary: Warthin Tumor, also known as papillary cystadenoma lymphomatosum, is related to mucoepidermoid esophageal carcinoma and spiradenoma. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways are Proteoglycans in cancer and Development EGFR signaling pathway. Affiliated tissues include salivary gland, endothelial and heart, and related mouse phenotypes are respiratory system and muscle.

Related Diseases for Warthin Tumor

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Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1mucoepidermoid esophageal carcinoma10.6CRTC1, MAML2
2spiradenoma10.6CRTC1, MAML2
3vulvitis10.5CRTC1, MAML2
4adenosquamous pancreas carcinoma10.5CRTC1, MAML2
5endometrial transitional cell carcinoma10.3CRTC1, KRT18, MAML2
6adult epithelioid sarcoma10.3KIT, KRT7
7mucinous tubular and spindle renal cell carcinoma10.3KIT, KRT7
8eccrine acrospiroma10.3ERBB4, KIT
9male reproductive organ cancer10.3KRT18, KRT7
10follicular basal cell carcinoma10.3KIT, KRT7
11gastrointestinal system cancer10.2KIT, KRT7
12pagod syndrome10.2ERBB4, KRT7
13breast pericanalicular fibroadenoma10.1KRT18, KRT7
14lymphoma10.1
15lacrimal gland mucoepidermoid carcinoma10.1CRTC1, KRT7, MAML2
16strabismus10.1CRTC1, KRT7, MAML2
17bowenoid papulosis10.1KRT7, TGFB2
18tuberculosis10.1
19mucoepidermoid carcinoma10.1
20ovarian brenner tumor10.1KIT, KRT7
21cervical large cell neuroendocrine carcinoma10.0KIT, KRT18, KRT7
22cervicitis10.0
23cystadenoma10.0
24thyroiditis10.0
25renal cell carcinoma, papillary10.0KIT, KRT7
26connective tissue benign neoplasm10.0KIT, KRT7
27adenocarcinoma9.9
28acantholytic squamous cell skin carcinoma9.9KIT, KRT7
29mucocele of salivary gland9.8CRTC1, KIT, KRT7, MAML2
30hodgkin lymphoma9.8
31b-cell lymphomas9.8
32diffuse large b-cell lymphoma9.8
33mantle cell lymphoma9.8
34peripheral t-cell lymphoma9.8
35nasopharyngitis9.8
36necrotizing sialometaplasia9.8
37thyroid cancer9.8
38mandibular cancer9.8
39langerhans-cell histiocytosis9.8
40histiocytosis9.8
41pleomorphic adenoma9.8
42adenoma9.8
43actinomycosis9.8
44tongue cancer9.8
45nodular lymphocyte predominant hodgkin lymphoma9.8
46male reproductive organ benign neoplasm9.7KIT, KRT7
47wdha syndrome6.1CEACAM5, CRTC1, CRTC3, ERBB4, HBEGF, KIT

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms for Warthin Tumor

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Drugs & Therapeutics for Warthin Tumor

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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MalaCards organs/tissues related to Warthin Tumor:

33
Salivary gland, Endothelial, Heart, Thyroid, T cells, Testes, Cervix

Animal Models for Warthin Tumor or affiliated genes

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MGI Mouse Phenotypes related to Warthin Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7ERBB4, HBEGF, KIT, TGFB2, THY1
2MP:00053698.5CRTC3, ERBB4, HBEGF, KIT, TGFA, TGFB2

Publications for Warthin Tumor

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Articles related to Warthin Tumor:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Synchronous parotid and nasopharyngeal Warthin tumor. (26315140)
2015
2
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. (26119391)
2015
3
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. (25992164)
2015
4
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. (25816418)
2015
5
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. (24791853)
2014
6
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (24565204)
2014
7
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. (25149652)
2014
8
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (24880872)
2014
9
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
10
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. (23863526)
2013
11
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
12
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
13
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
14
Warthin tumor in an unusual site: a case report. (23715204)
2013
15
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
16
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
17
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
18
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
19
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
20
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
21
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
22
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
23
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
24
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. (21549478)
2011
25
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
26
Brucella melitensis infection within warthin tumor of the parotid gland. (21959459)
2011
27
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
28
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
29
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
30
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
31
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
32
Warthin tumor: a curious entity--case reports and review of literature. (19434322)
2009
33
Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. (19031731)
2008
34
Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. (15994480)
2005
35
Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. (16000851)
2005
36
Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate. (16012309)
2005
37
Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation. (15313720)
2004
38
Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. (12811857)
2003
39
Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature. (11026102)
2000
40
Follicle center lymphoma and Warthin tumor involving the same anatomic site. Report of two cases and review of the literature. (10631864)
2000
41
Quiz case 2. Warthin tumor. (10555703)
1999
42
Warthin tumor. A new hypothesis concerning its development. (9474616)
1998
43
Molecular characterization of Warthin tumor. (9619676)
1998
44
An unusual neck mass: the Warthin tumor. (9581198)
1998
45
Warthin tumor of the lacrimal gland. (9402842)
1997
46
Aspiration cytology features of the warthin tumor-like variant of papillary thyroid carcinoma. A report of two cases. (9990276)
1997
47
Warthin tumor of the parotid gland: MR-pathologic correlation. (8427092)
1993
48
Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. (7281493)
1981
49
Letter: Warthin tumor in two brothers. (988997)
1976
50
Papillary cystadenoma lymphomatosum (Warthin tumor). (5639487)
1968

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.3ERBB4, KIT
2somatic stem cell divisionGO:004810310.3KIT, TGFB2
3regulation of cell motilityGO:200014510.3ERBB4, HBEGF
4phosphatidylinositol phosphorylationGO:004685410.3HBEGF, KIT
5signal transduction by protein phosphorylationGO:002301410.2ERBB4, TGFB2
6positive regulation of CREB transcription factor activityGO:003279310.1CRTC1, CRTC3
7positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.0ERBB4, KIT
8cell chemotaxisGO:006032610.0HBEGF, KIT
9phosphatidylinositol-mediated signalingGO:00480159.9ERBB4, HBEGF, KIT
10positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.8ERBB4, KIT, TGFB2
11MAPK cascadeGO:00001659.6ERBB4, HBEGF, KIT
12protein homotetramerizationGO:00512899.5CRTC1, CRTC3
13activation of MAPKK activityGO:00001869.5ERBB4, HBEGF, KIT
14vascular endothelial growth factor receptor signaling pathwayGO:00480109.4ERBB4, HBEGF, KIT
15protein autophosphorylationGO:00467779.3ERBB4, KIT, THY1
16insulin receptor signaling pathwayGO:00082869.2ERBB4, HBEGF, KIT

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.5ERBB4, HBEGF, KIT

Sources for Warthin Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet