MCID: WRT003
MIFTS: 36

Warthin Tumor malady

Immune diseases, Cancer diseases categories

Summaries for Warthin Tumor

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Warthin tumor is an unusual growth of cells (tumor) in a salivary gland.  the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin.  warthin tumors may increase in size over time, but few become cancerous.  though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor.  treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 10/10/2012

MalaCards: Warthin Tumor, also known as papillary cystadenoma lymphomatosum, is related to mucoepidermoid carcinoma and adenocarcinoma. An important gene associated with Warthin Tumor is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and GPCR Pathway. The compounds cycloheximide and pertuzumab have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Warthin Tumor

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

warthin tumor 42
papillary cystadenoma lymphomatosum 42
adenolymphoma 60


Related Diseases for Warthin Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1mucoepidermoid carcinoma30.4MAML2, CRTC1
2adenocarcinoma30.2HBEGF, KRT18, NOS2, ERBB4, BCL2, CEACAM5
3necrotizing sialometaplasia30.0MAML2, CRTC1
4cervical cancer30.0KRT18, ERBB4, BCL2
5adenoma30.0HBEGF, KRT18, BCL2, CEACAM5, TGFA
6tuberculosis10.3
7cystadenoma10.3
8thyroiditis10.3
9papillary carcinoma10.2
10cervicitis10.2
11papillary thyroid carcinoma10.2
12pleomorphic adenoma10.0
13mandibular cancer10.0
14actinomycosis10.0
15tongue cancer10.0
16lymph node tuberculosis10.0
17histiocytosis10.0
18in situ carcinoma10.0
19langerhans-cell histiocytosis10.0
20lymph node cancer10.0
21thyroid cancer10.0
22malignant mesothelioma10.0CEACAM5
23fibrosarcoma10.0THY1
24infertility10.0TGFB2
25myelodysplastic syndromes10.0KIT
26meningioma10.0TGFA
27seborrheic keratosis10.0TGFB2
28liver cirrhosis10.0KRT18
29germ cell tumors10.0KIT
30mastocytosis10.0KIT
31glaucoma10.0TGFB2
32medulloblastoma10.0ERBB4
33thymoma10.0THY1
34viral hepatitis10.0KRT18
35teratoma10.0KIT
36cutaneous mucoepidermoid carcinoma10.0CRTC1, MAML2
37lacrimal gland cancer10.0CRTC1, MAML2
38leiomyosarcoma10.0KIT
39lipoadenoma10.0MAML2, CRTC1
40cholesteatoma10.0TGFA
41arthritis10.0NOS2
42cervical adenosquamous carcinoma10.0CRTC1, MAML2
43epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
44gastrointestinal system disease10.0NOS2
45gastrointestinal stromal tumor10.0KIT
46rectal neoplasm10.0HBEGF, CEACAM5
47hidradenoma10.0MAML2, CRTC1
48hepatitis c10.0KRT18
49sarcoma10.0THY1, KIT
50cholangiocarcinoma10.0KRT18, CEACAM5

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Clinical Features for Warthin Tumor

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Drugs & Therapeutics for Warthin Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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32MalaCards
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MalaCards organs/tissues related to Warthin Tumor:

32
Salivary gland

Animal Models for Warthin Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Warthin Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.9BCL2, KIT
2MP:00053699.5ERBB4, TGFA, TGFB2
3MP:00053889.4TGFB2, BCL2, ERBB4, HBEGF
4MP:00107719.2HBEGF, BCL2, TGFA
5MP:00036318.7BCL2, ERBB4, NOS2, KIT
6MP:00053818.6NOS2, BCL2, TGFA, TGFB2, KIT
7MP:00053898.5CRTC1, ERBB4, BCL2, TGFA, TGFB2
8MP:00053828.3KIT, NOS2, ERBB4, BCL2, TGFA, TGFB2
9MP:00053857.7CRTC1, HBEGF, KIT, NOS2, ERBB4, BCL2
10MP:00053787.6CRTC1, HBEGF, KIT, KRT18, NOS2, BCL2

Publications for Warthin Tumor

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Genetic Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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Sources:
52R&D Systems, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Warthin Tumor according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1BCL2
2
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10.1ERBB4
3
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10.1ERBB4
4
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9.8ERBB4, HBEGF
5
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9.7ERBB4, KIT
6
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9.5ERBB4, KIT, HBEGF
7
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9.5HBEGF, KIT, ERBB4
8
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9.5HBEGF, KIT, ERBB4
99.5TGFB2, BCL2, NOS2
109.5TGFB2, BCL2, NOS2
119.5KIT, ERBB4, TGFB2
12
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9.3HBEGF, ERBB4, TGFA
139.2TGFA, ERBB4, KIT
14
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8.9KIT, ERBB4, TGFA, TGFB2
15
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8.9KIT, ERBB4, TGFA, TGFB2
16
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8.9HBEGF, ERBB4, BCL2, TGFA
178.8CEACAM5, THY1, KIT
188.6TGFB2, TGFA, BCL2, NOS2, KIT
19
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8.6KIT, ERBB4, BCL2, TGFA, TGFB2
20
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8.6KIT, ERBB4, BCL2, TGFA, TGFB2
218.5ERBB4, NOS2, KIT, HBEGF, MAML2
22
Hide members
8.3KIT, KRT18, ERBB4, BCL2, TGFA, TGFB2

Compounds for genes affiliated with Warthin Tumor

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Warthin Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6HBEGF
2pertuzumab44 49 1111.9ERBB4, TGFA
3hrgbeta1449.9ERBB4, TGFA
4docetaxel44 49 59 1112.7KRT18, KIT, BCL2
5steroid449.7KRT18, TGFA, TGFB2
6trastuzumab44 49 1111.6KIT, ERBB4, TGFA
7gold449.6KRT18, CEACAM5
8dexamethasone44 49 28 1112.6BCL2, TGFB2, HBEGF, KRT18
9mg 13244 5910.6KRT18, BCL2, NOS2
10ozone449.6TGFB2, TGFA
11tgf beta1449.5TGFB2, TGFA, HBEGF
12bromodeoxyuridine449.5KRT18, TGFA, TGFB2, HBEGF
13matrigel449.5HBEGF, TGFB2, TGFA, KRT18
145-deoxy-5-fluorouridine449.4CEACAM5, TGFA
15hematoxylin449.4KRT18, CEACAM5, KIT
16ascorbic acid44 2410.4KRT18, TGFB2, TGFA, NOS2
17resveratrol44 59 11 2412.4NOS2, TGFB2, TGFA, BCL2
18p003449.3KIT, CEACAM5, TGFB2
19pd 98,059449.3KIT, BCL2, HBEGF, TGFA
20formaldehyde44 2410.3TGFA, KRT18, KIT
21n acetylcysteine449.3TGFB2, BCL2, NOS2, HBEGF, KRT18
22p002449.3KIT, KRT18, CEACAM5
23ly294002449.3NOS2, TGFA, HBEGF, BCL2
24nitric oxide44 11 2411.3KIT, NOS2, KRT18, TGFB2, HBEGF
25tamoxifen44 49 28 1112.3ERBB4, TGFA, TGFB2, BCL2
26testosterone44 59 11 2412.2KRT18, TGFB2, TGFA, HBEGF, KIT
27dopamine44 28 11 2412.2KRT18, ERBB4, TGFB2, TGFA
28mitomycin c449.1BCL2, CEACAM5, TGFA
29glucose449.1KRT18, CEACAM5, TGFB2
30oxygen44 2410.0HBEGF, NOS2, ERBB4, BCL2, KRT18
31quercetin44 59 11 2411.9NOS2, BCL2, TGFA
32ribonucleic acid448.9KIT, TGFA, TGFB2, CEACAM5
33estradiol44 11 2410.9TGFA, HBEGF, TGFB2, CEACAM5
34gefitinib44 49 1110.8TGFA, CEACAM5, ERBB4, KIT
35oligonucleotide448.8KRT18, TGFA, TGFB2, BCL2, KIT, HBEGF
36retinoic acid44 249.8HBEGF, KRT18, BCL2, TGFB2, KIT, TGFA
37actinomycin d448.8KRT18, NOS2, BCL2, HBEGF, KIT, TGFA
38cisplatin44 49 59 1111.8HBEGF, CEACAM5, ERBB4, BCL2
39lactate448.7KIT, KRT18, CEACAM5, TGFA
40genistein44 28 59 2 11 2413.7BCL2, HBEGF, NOS2, ERBB4, TGFA, TGFB2
41thymidine44 249.4TGFB2, KRT18, KIT, CEACAM5, TGFA, HBEGF
42cysteine448.3TGFB2, TGFA, CEACAM5, KIT, HBEGF
43agar448.3TGFB2, TGFA, CEACAM5, ERBB4, KRT18, HBEGF
445fluorouracil448.3CEACAM5, TGFB2, TGFA, KIT, KRT18, BCL2
45doxorubicin44 49 1110.2BCL2, KIT, NOS2, KRT18, TGFA, CEACAM5
46paraffin448.0KRT18, KIT, HBEGF, CEACAM5, TGFA, BCL2
47phosphatidylinositol447.9TGFA, TGFB2, ERBB4, KIT, BCL2, HBEGF
48progesterone44 59 28 11 2411.6HBEGF, CEACAM5, KIT, KRT18, BCL2, ERBB4
49tyrosine447.4CEACAM5, ERBB4, KRT18, THY1, HBEGF, TGFB2
50vegf447.3NOS2, HBEGF, KIT, KRT18, ERBB4, BCL2

GO Terms for genes affiliated with Warthin Tumor

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16Gene Ontology
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Cellular components related to Warthin Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163238.7TGFA, CEACAM5, ERBB4

Biological processes related to Warthin Tumor according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:02301410.1TGFB2, KIT
2lymphoid progenitor cell differentiationGO:00232010.1BCL2, KIT
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0KIT, ERBB4
4response to radiationGO:0093149.9KIT, BCL2
5positive regulation of cell growthGO:0303079.8HBEGF, BCL2, TGFB2
6positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8ERBB4, KIT
7mammary gland alveolus developmentGO:0607499.8ERBB4, TGFA
8focal adhesion assemblyGO:0480419.8BCL2, THY1
9phosphatidylinositol-mediated signalingGO:0480159.7ERBB4, KIT, HBEGF
10melanocyte differentiationGO:0303189.7BCL2, KIT
11fibroblast growth factor receptor signaling pathwayGO:0085439.6ERBB4, KIT, HBEGF
12hair follicle morphogenesisGO:0310699.5TGFB2, BCL2
13Fc-epsilon receptor signaling pathwayGO:0380959.5HBEGF, KIT, ERBB4
14epidermal growth factor receptor signaling pathwayGO:0071739.3TGFA, ERBB4, KIT, HBEGF
15angiogenesisGO:0015259.1TGFB2, TGFA, THY1
16negative regulation of apoptotic processGO:0430669.0KRT18, ERBB4, BCL2, TGFA

Molecular functions related to Warthin Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:0047169.6ERBB4, KIT
2epidermal growth factor receptor bindingGO:0051549.3TGFA, ERBB4, HBEGF
3growth factor activityGO:0080839.1HBEGF, TGFA, TGFB2
4protein homodimerization activityGO:0428038.7KIT, NOS2, ERBB4, BCL2, TGFB2
5protein bindingGO:0055156.9KIT, THY1, KRT18, NOS2, ERBB4, BCL2

Products for genes affiliated with Warthin Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Warthin Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet