MCID: WRT003
MIFTS: 35

Warthin Tumor malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Warthin Tumor

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Aliases & Descriptions for Warthin Tumor:

Name: Warthin Tumor 46
Papillary Cystadenoma Lymphomatosum 46
 
Adenolymphoma 66

Classifications:



Summaries for Warthin Tumor

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NIH Rare Diseases:46 Warthin tumor is a benign tumor of the salivary gland. the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. warthin tumors may increase in size over time, but few become cancerous. though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor. treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 9/8/2015

MalaCards based summary: Warthin Tumor, also known as papillary cystadenoma lymphomatosum, is related to mucoepidermoid thyroid carcinoma and syringocystadenoma papilliferum. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cell adhesion_ECM remodeling. Affiliated tissues include salivary gland, lymph node and thyroid, and related mouse phenotypes are respiratory system and reproductive system.

Related Diseases for Warthin Tumor

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Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1mucoepidermoid thyroid carcinoma10.7CRTC1, MAML2
2syringocystadenoma papilliferum10.7CRTC1, MAML2
3bronchial neoplasm10.6CRTC1, MAML2
4breast rhabdomyosarcoma10.6KIT, KRT18
5animal phobia10.6KIT, KRT18
6malignant giant cell tumor of soft parts10.6CRTC1, MAML2
7water-clear cell adenoma10.5CRTC1, MAML2
8cribriform carcinoma10.5KIT, KRT18
9sialolithiasis10.4CRTC1, KIT, MAML2
10rectum carcinoma in situ10.4CEACAM5, KIT
11urinary bladder urothelial carcinoma10.4CRTC1, KRT18, MAML2
12adhesions of uterus10.4CEACAM5, KIT
13clear cell hidradenoma10.4ERBB4, KIT
14anterior horn cell disease10.4CEACAM5, KRT18
15infiltrative basal cell carcinoma10.4CEACAM5, KIT
16sphenoidal sinus cancer10.3CEACAM5, KIT
17breast papillary carcinoma10.3CEACAM5, KIT
18ovary epithelial cancer10.3CEACAM5, KRT18
19localized pulmonary fibrosis10.3CEACAM5, KIT
20congenital disorder of glycosylation, type iq10.3KIT, TGFA
21bladder clear cell adenocarcinoma10.3CEACAM5, KRT18
22dysgraphia10.3CRTC1, CRTC3, MAML2
23mucoepidermoid esophageal carcinoma10.2CEACAM5, CRTC1, MAML2
24human t-cell leukemia virus type 310.1CRTC1, CRTC3
25lymphoma10.1
26retroperitoneal leiomyosarcoma10.1CD44, KIT
27posteroinferior myocardial infarction10.1CEACAM5, KIT
28tuberculosis10.1
29mucoepidermoid carcinoma10.1
30thyroiditis10.1
31cervicitis10.0
32cystadenoma10.0
33adenocarcinoma9.9
34bilirubin metabolic disorder9.9CD44, HBEGF
35hypereosinophilic syndrome, idiopathic, resistant to imatinib9.9CD44, KIT
36rhizomelic pseudopolyarthritis9.8CD44, VCAM1
37hodgkin lymphoma9.8
38b-cell lymphomas9.8
39diffuse large b-cell lymphoma9.8
40mantle cell lymphoma9.8
41peripheral t-cell lymphoma9.8
42nasopharyngitis9.8
43necrotizing sialometaplasia9.8
44thyroid cancer9.8
45mandibular cancer9.8
46langerhans-cell histiocytosis9.8
47histiocytosis9.8
48pleomorphic adenoma9.8
49adenoma9.8
50actinomycosis9.8

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms for Warthin Tumor

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Drugs & Therapeutics for Warthin Tumor

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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MalaCards organs/tissues related to Warthin Tumor:

34
Salivary gland, Lymph node, Thyroid, Tongue, B cells, T cells, Lung

Animal Models for Warthin Tumor or affiliated genes

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MGI Mouse Phenotypes related to Warthin Tumor:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CD44, ERBB4, HBEGF, KIT, TGFB2, THY1
2MP:00053898.0CD44, CRTC1, ERBB4, KIT, TGFA, TGFB2
3MP:00053697.9CD44, CRTC3, ERBB4, HBEGF, KIT, TGFA
4MP:00053857.6CD44, ERBB4, HBEGF, KIT, TGFA, TGFB2
5MP:00053786.9CD44, CRTC1, CRTC3, HBEGF, KIT, KRT18

Publications for Warthin Tumor

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Articles related to Warthin Tumor:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Incidental Warthin Tumor on Pertechnetate Scintigraphy. (27405035)
2016
2
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. (26634829)
2015
3
Synchronous parotid and nasopharyngeal Warthin tumor. (26315140)
2015
4
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. (26119391)
2015
5
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. (25992164)
2015
6
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (24880872)
2014
7
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. (24791853)
2014
8
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
9
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
10
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. (23635480)
2013
11
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
12
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. (23863526)
2013
13
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
14
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
15
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
16
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
17
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. (22576704)
2012
18
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
19
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
20
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
21
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
22
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
23
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
24
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
25
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. (21493251)
2011
26
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
27
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
28
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
29
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
30
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
31
Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases. (19625134)
2010
32
Mycobacterium tuberculosis infection within parotid gland Warthin tumor. (19098552)
2008
33
Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. (15994480)
2005
34
Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. (16000851)
2005
35
Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. (12811857)
2003
36
False diagnosis caused by Warthin tumor of the parotid gland combined with actinomycosis. (12544220)
2003
37
Increased uptake on I-131 whole-body scintigraphy in Warthin tumor despite false-negative Tc-99m pertechnetate salivary gland scintigraphy. (14578721)
2003
38
Papillary cystadenoma lymphomatosum (Warthin tumor). (14702874)
2003
39
Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature. (11026102)
2000
40
An unusual neck mass: the Warthin tumor. (9581198)
1998
41
Warthin tumor. A new hypothesis concerning its development. (9474616)
1998
42
Warthin tumor of the lacrimal gland. (9402842)
1997
43
Aspiration cytology features of the warthin tumor-like variant of papillary thyroid carcinoma. A report of two cases. (9990276)
1997
44
No significant role of Epstein-Barr virus in the tumorigenesis of Warthin tumor. (9608281)
1997
45
Warthin tumor of the parotid gland: MR-pathologic correlation. (8427092)
1993
46
Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. (7281493)
1981
47
Warthin tumor. B-lymphocytes within the lymphoid infiltrate. (326225)
1977
48
Letter: Warthin tumor in two brothers. (988997)
1976
49
Papillary cystadenoma lymphomatosum (Warthin tumor). (5639487)
1968
50
Papillary cystadenoma of the maxillary paranasal sinus (atypical Warthin tumor). (13123647)
1954

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163238.9CEACAM5, ERBB4, TGFA
2cell surfaceGO:00099868.1CD44, HBEGF, KIT, TGFA, THY1, VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1somatic stem cell divisionGO:004810310.6KIT, TGFB2
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.4ERBB4, KIT
3phosphatidylinositol phosphorylationGO:004685410.1ERBB4, HBEGF, KIT
4regulation of phosphatidylinositol 3-kinase signalingGO:001406610.1ERBB4, HBEGF, KIT
5regulation of cell motilityGO:200014510.1ERBB4, HBEGF
6phosphatidylinositol-mediated signalingGO:004801510.1ERBB4, HBEGF, KIT
7mammary gland alveolus developmentGO:006074910.0ERBB4, TGFA
8positive regulation of CREB transcription factor activityGO:00327939.9CRTC1, CRTC3
9peptidyl-tyrosine phosphorylationGO:00181089.9ERBB4, HBEGF, KIT
10positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.9ERBB4, KIT, TGFB2
11protein autophosphorylationGO:00467779.7ERBB4, KIT, THY1
12cell chemotaxisGO:00603269.7HBEGF, KIT, VCAM1
13extracellular matrix organizationGO:00301989.5CD44, TGFB2, VCAM1
14cell migrationGO:00164779.2ERBB4, HBEGF, TGFB2
15viral processGO:00160328.9CRTC1, CRTC3, KRT18, VCAM1
16positive regulation of cell proliferationGO:00082848.7ERBB4, HBEGF, KIT, TGFA, TGFB2
17negative regulation of apoptotic processGO:00430668.0CD44, CEACAM5, ERBB4, KRT18, TGFA

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.4ERBB4, KIT
2phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.0ERBB4, HBEGF, KIT
3transmembrane receptor protein tyrosine kinase activityGO:00047149.9ERBB4, KIT
4epidermal growth factor receptor bindingGO:00051549.7ERBB4, HBEGF, TGFA
5protein tyrosine kinase activityGO:00047139.7ERBB4, HBEGF, KIT
6cAMP response element binding protein bindingGO:00081409.5CRTC1, CRTC3
7Ras guanyl-nucleotide exchange factor activityGO:00050889.2ERBB4, HBEGF, KIT
8growth factor activityGO:00080839.2HBEGF, TGFA, TGFB2
9GPI anchor bindingGO:00342359.1CEACAM5, THY1

Sources for Warthin Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet