Aliases & Classifications for Warthin Tumor

MalaCards integrated aliases for Warthin Tumor:

Name: Warthin Tumor 49
Adenolymphoma 69

Classifications:



External Ids:

UMLS 69 C0001429

Summaries for Warthin Tumor

NIH Rare Diseases : 49 Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous. Though the cause is currently unknown, smoking is believed to increase the chance of developing Warthin tumor. Treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. Last updated: 9/8/2015

MalaCards based summary : Warthin Tumor, also known as adenolymphoma, is related to necrotizing sialometaplasia and squamous cell carcinoma. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are p70S6K Signaling and NF-kappaB Signaling. Affiliated tissues include salivary gland, lymph node and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Warthin Tumor

Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 necrotizing sialometaplasia 29.6 CRTC1 KIT KRT7 MAML2
2 squamous cell carcinoma 29.0 CD44 CEACAM5 ERBB4 KRT7
3 mucoepidermoid carcinoma 28.8 CEACAM5 CRTC1 CRTC3 KRT7 MAML2
4 lacrimal gland mucoepidermoid carcinoma 10.6 CRTC1 MAML2
5 clear cell hidradenoma 10.6 CRTC1 MAML2
6 prostate leiomyosarcoma 10.5 CD44 KIT
7 gallbladder sarcoma 10.5 KIT KRT18
8 cervical adenosquamous carcinoma 10.4 CRTC1 MAML2
9 schneiderian carcinoma 10.3 CRTC1 KRT18 MAML2
10 skin atrophy 10.3 CD44 HBEGF
11 hypereosinophilic syndrome, idiopathic 10.3 KIT TGFA
12 jejunal cancer 10.3 KIT KRT7
13 proliferating trichilemmal cyst 10.3 KRT18 KRT7
14 cribriform carcinoma 10.3 KIT KRT7
15 malignant mixed mullerian tumor 10.3 KIT KRT7
16 papillary hidradenoma 10.3 ERBB4 KIT
17 epithelioid trophoblastic tumor 10.3 KRT18 KRT7
18 rheumatoid vasculitis 10.3 CD44 VCAM1
19 intratubular embryonal carcinoma 10.3 KIT KRT7
20 malignant leydig cell tumor 10.3 KIT KRT7
21 liver leiomyoma 10.3 CEACAM5 KIT
22 fox-fordyce disease 10.2 CEACAM5 KIT
23 metanephric adenoma 10.2 KRT18 KRT7
24 seminal vesicle tumor 10.2 KRT18 KRT7
25 aggressive digital papillary adenocarcinoma 10.2 CEACAM5 KIT
26 ovarian lymphoma 10.2 CEACAM5 KRT18
27 hidradenoma 10.2 CRTC1 KRT7 MAML2
28 lipoadenoma 10.2 CRTC1 KRT7 MAML2
29 rete testis adenocarcinoma 10.2 CEACAM5 KIT
30 mucinous tubular and spindle renal cell carcinoma 10.2 KRT18 KRT7
31 paget disease, extramammary 10.1 ERBB4 KRT7
32 kidney benign neoplasm 10.1 KIT KRT7
33 lymphoma 10.1
34 transitional cell carcinoma 10.1 CD44 KRT18 KRT7
35 pleomorphic carcinoma 10.1 KIT KRT18 KRT7
36 ovarian brenner tumor 10.1 KIT KRT18 KRT7
37 oncocytoma 10.1 KIT KRT18 KRT7
38 lymphoepithelioma-like carcinoma 10.1 KRT18 KRT7
39 chromophobe renal cell carcinoma 10.1 KIT KRT18 KRT7
40 anal gland adenocarcinoma 10.1 CEACAM5 KRT7
41 cervical clear cell adenocarcinoma 10.1 CEACAM5 KRT18
42 dermoid cyst 10.1 KIT KRT7
43 anus adenocarcinoma 10.1 CEACAM5 KRT7
44 mucinous adenofibroma 10.1 CEACAM5 KRT7
45 malignant spiradenoma 10.1 CEACAM5 KRT7
46 bile duct mucoepidermoid carcinoma 10.1 CEACAM5 KRT7
47 prostate squamous cell carcinoma 10.1 CEACAM5 KRT7
48 nodular hidradenoma 10.1 CEACAM5 KRT7
49 vulval paget's disease 10.1 CEACAM5 KRT7
50 pancreatic serous cystadenoma 10.0 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to Warthin Tumor

Symptoms & Phenotypes for Warthin Tumor

GenomeRNAi Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 TGFB2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.53 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.53 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.53 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.53 TGFB2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.53 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.53 TGFB2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.53 TGFB2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 KRT18 KRT7 TGFB2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.53 KRT7 TGFB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 KRT18
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 KRT7

MGI Mouse Phenotypes related to Warthin Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 CD44 CRTC1 CRTC3 HBEGF KIT KRT18
2 muscle MP:0005369 9.7 CRTC3 ERBB4 HBEGF KIT TGFA TGFB2
3 reproductive system MP:0005389 9.5 CD44 CRTC1 ERBB4 KIT TGFA TGFB2
4 respiratory system MP:0005388 9.1 CD44 ERBB4 HBEGF KIT TGFB2 THY1

Drugs & Therapeutics for Warthin Tumor

Search Clinical Trials , NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

Anatomical Context for Warthin Tumor

MalaCards organs/tissues related to Warthin Tumor:

38
Salivary Gland, Lymph Node, Thyroid, Tongue, B Cells, T Cells, Lung

Publications for Warthin Tumor

Articles related to Warthin Tumor:

(show top 50) (show all 83)
# Title Authors Year
1
Extracapsular dissection for Warthin tumor in the tail of parotid gland. ( 28446044 )
2017
2
Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in a Warthin Tumor: Case Report and Literature Review. ( 28978260 )
2017
3
Incidental finding of upper lip Warthin tumor. ( 29134953 )
2017
4
Warthin Tumor-Like Mucoepidermoid Carcinoma. ( 28793830 )
2017
5
If cytology of Warthin tumor is accurate, can management be conservative? ( 27140020 )
2016
6
Incidental Warthin Tumor on Pertechnetate Scintigraphy. ( 27405035 )
2016
7
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. ( 28013343 )
2016
8
Letter to the Editor: Multinucleated cells in parotid Warthin tumor: a potential diagnostic pitfall? ( 28174818 )
2016
9
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. ( 27438374 )
2016
10
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. ( 27806841 )
2016
11
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. ( 25992164 )
2015
12
Synchronous parotid and nasopharyngeal Warthin tumor. ( 26315140 )
2015
13
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. ( 26170867 )
2015
14
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. ( 26169920 )
2015
15
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. ( 25816418 )
2015
16
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. ( 26119391 )
2015
17
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. ( 26634829 )
2015
18
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. ( 25149652 )
2014
19
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. ( 24565204 )
2014
20
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. ( 24880872 )
2014
21
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. ( 24791853 )
2014
22
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. ( 24350077 )
2013
23
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. ( 23579981 )
2013
24
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. ( 23863526 )
2013
25
Warthin tumor in an unusual site: a case report. ( 23715204 )
2013
26
Letter to the editor. parotid Warthin tumor with mucous differentiation. ( 23529335 )
2013
27
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. ( 23635480 )
2013
28
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. ( 24121173 )
2013
29
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. ( 23868565 )
2013
30
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. ( 22227551 )
2012
31
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. ( 22576704 )
2012
32
Mycobacterial tuberculosis superimposed on a Warthin tumor. ( 22614566 )
2012
33
Adenocarcinoma arising in warthin tumor of the parotid gland. ( 23011833 )
2012
34
Warthin tumor arising from the minor salivary gland. ( 22976673 )
2012
35
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. ( 22990554 )
2012
36
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. ( 22976724 )
2012
37
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. ( 21591273 )
2012
38
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. ( 22991990 )
2012
39
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. ( 21493251 )
2011
40
Warthin tumor--morphological study of the stromal compartment. ( 22203940 )
2011
41
Warthin tumor of the upper lip: an unusual location of a benign salivary gland tumor. ( 19189998 )
2011
42
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. ( 21877991 )
2011
43
Brucella melitensis infection within warthin tumor of the parotid gland. ( 21959459 )
2011
44
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. ( 21934225 )
2011
45
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. ( 21769315 )
2011
46
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. ( 21549478 )
2011
47
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. ( 20090459 )
2010
48
Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases. ( 19625134 )
2010
49
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. ( 19969491 )
2010
50
Familial Warthin tumor: occurrence in monozygotic twins. ( 19944513 )
2010

Variations for Warthin Tumor

Expression for Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for Warthin Tumor

GO Terms for Warthin Tumor

Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.1 CD44 HBEGF KIT TGFA THY1 VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.73 ERBB4 HBEGF KIT
2 positive regulation of protein kinase B signaling GO:0051897 9.72 ERBB4 HBEGF KIT
3 negative regulation of apoptotic process GO:0043066 9.72 CD44 CEACAM5 ERBB4 KRT18 TGFA
4 phosphatidylinositol phosphorylation GO:0046854 9.65 ERBB4 HBEGF KIT
5 positive regulation of cell proliferation GO:0008284 9.65 ERBB4 HBEGF KIT TGFA TGFB2
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 CD44 HBEGF TGFA
7 energy homeostasis GO:0097009 9.54 CRTC1 CRTC3
8 cell chemotaxis GO:0060326 9.54 HBEGF KIT VCAM1
9 mammary gland alveolus development GO:0060749 9.52 ERBB4 TGFA
10 positive regulation of CREB transcription factor activity GO:0032793 9.51 CRTC1 CRTC3
11 negative regulation of ERBB signaling pathway GO:1901185 9.49 ERBB4 HBEGF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.46 CD44 THY1
13 somatic stem cell division GO:0048103 9.4 KIT TGFB2
14 viral process GO:0016032 9.35 CRTC1 CRTC3 KRT18 KRT7 VCAM1
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.33 ERBB4 KIT TGFB2
16 cell-cell adhesion GO:0098609 8.92 CD44 KRT18 THY1 VCAM1

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.61 HBEGF TGFA TGFB2
2 protein tyrosine kinase activity GO:0004713 9.58 ERBB4 HBEGF KIT
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 ERBB4 HBEGF KIT
4 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.32 ERBB4 KIT
5 cAMP response element binding protein binding GO:0008140 9.26 CRTC1 CRTC3
6 GPI anchor binding GO:0034235 9.16 CEACAM5 THY1
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 ERBB4 HBEGF KIT
8 epidermal growth factor receptor binding GO:0005154 8.8 ERBB4 HBEGF TGFA

Sources for Warthin Tumor

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