MCID: WRT003
MIFTS: 32

Warthin Tumor malady

Category: Rare diseases

Aliases & Classifications for Warthin Tumor

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Aliases & Descriptions for Warthin Tumor:

Name: Warthin Tumor 48
 
Adenolymphoma 68

Classifications:



Summaries for Warthin Tumor

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NIH Rare Diseases:48 Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous. Though the cause is currently unknown, smoking is believed to increase the chance of developing Warthin tumor. Treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. Last updated: 9/8/2015

MalaCards based summary: Warthin Tumor, also known as adenolymphoma, is related to mucoepidermoid thyroid carcinoma and syringocystadenoma papilliferum. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cell adhesion_ECM remodeling. Affiliated tissues include salivary gland, lymph node and thyroid, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and reproductive system.

Related Diseases for Warthin Tumor

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Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1mucoepidermoid thyroid carcinoma10.7CRTC1, MAML2
2syringocystadenoma papilliferum10.7CRTC1, MAML2
3retroperitoneal leiomyosarcoma10.6CD44, KIT
4malignant giant cell tumor of soft parts10.6CRTC1, MAML2
5breast rhabdomyosarcoma10.6KIT, KRT18
6animal phobia10.6KIT, KRT18
7rhizomelic pseudopolyarthritis10.5CD44, VCAM1
8congenital disorder of glycosylation, type iq10.4KIT, TGFA
9cribriform carcinoma10.4KIT, KRT18
10bilirubin metabolic disorder10.4CD44, HBEGF
11clear cell hidradenoma10.4ERBB4, KIT
12hypereosinophilic syndrome, idiopathic, resistant to imatinib10.4CD44, KIT
13peritonitis10.4KIT, KRT7
14propriospinal myoclonus10.4KRT18, KRT7
15sarcomatoid renal cell carcinoma10.4KIT, KRT7
16malignant sertoli-leydig cell tumor10.4KIT, KRT7
17pemphigus vulgaris, familial10.3ERBB4, KRT7
18bronchus adenoma10.3KIT, KRT7
19large cell medulloblastoma10.3KRT18, KRT7
20water-clear cell adenoma10.3CRTC1, KRT7, MAML2
21rhinitis10.3KRT18, KRT7
22vibratory urticaria10.2KIT, KRT7
23rectum carcinoma in situ10.2CEACAM5, KIT
24adhesions of uterus10.1CEACAM5, KIT
25sphenoidal sinus cancer10.1CEACAM5, KIT
26breast papillary carcinoma10.1CEACAM5, KIT
27localized pulmonary fibrosis10.1CEACAM5, KIT
28ovary epithelial cancer10.1CEACAM5, KRT18
29bladder clear cell adenocarcinoma10.0CEACAM5, KRT18
30lymphoma10.0
31sialolithiasis10.0CRTC1, KIT, KRT7, MAML2
32breast adenocarcinoma10.0CEACAM5, KRT7
33subareolar duct papillomatosis10.0CEACAM5, KRT7
34tuberculosis10.0
35mucoepidermoid carcinoma10.0
36thyroiditis10.0
37uterine disease10.0CEACAM5, KRT7
38pigmented villonodular synovitis10.0CEACAM5, KRT7
39tamoxifen-related endometrial lesion9.9CEACAM5, KRT7
40internal hordeolum9.9CEACAM5, KRT7
41lacrimal gland mucoepidermoid carcinoma9.9CEACAM5, KRT7
42familial periodic paralysis9.9CEACAM5, KRT7
43thymus adenocarcinoma9.9CEACAM5, KRT7
44pancreatic serous cystic neoplasm9.9CEACAM5, KRT7
45tricuspid valve insufficiency9.9CEACAM5, KRT7
46heel spur9.9CEACAM5, KRT7
47vulva squamous cell carcinoma9.9CEACAM5, KRT7
48klatskin's tumor9.9CEACAM5, KRT7
49female breast lower-inner quadrant cancer9.9CEACAM5, KRT7
50breast neuroendocrine neoplasm9.9CEACAM5, KRT7

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms & Phenotypes for Warthin Tumor

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GenomeRNAi Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-5810.2KRT18, KRT7, TGFB2

MGI Mouse Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8CD44, CRTC1, ERBB4, KIT, TGFA, TGFB2
2MP:00053698.7CD44, CRTC3, ERBB4, HBEGF, KIT, TGFA
3MP:00053888.5CD44, ERBB4, HBEGF, KIT, TGFB2, THY1
4MP:00053788.0CD44, CRTC1, CRTC3, HBEGF, KIT, KRT18

Drugs & Therapeutics for Warthin Tumor

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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MalaCards organs/tissues related to Warthin Tumor:

36
Salivary gland, Lymph node, Thyroid, Tongue, B cells, T cells, Lung

Publications for Warthin Tumor

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Articles related to Warthin Tumor:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Incidental Warthin Tumor on Pertechnetate Scintigraphy. (27405035)
2016
2
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. (27806841)
2016
3
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. (28013343)
2016
4
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. (27438374)
2016
5
If cytology of Warthin tumor is accurate, can management be conservative? (27140020)
2016
6
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. (26634829)
2015
7
Synchronous parotid and nasopharyngeal Warthin tumor. (26315140)
2015
8
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. (26119391)
2015
9
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. (25992164)
2015
10
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. (25816418)
2015
11
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. (26170867)
2015
12
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. (26169920)
2015
13
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (24880872)
2014
14
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. (24791853)
2014
15
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (24565204)
2014
16
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. (25149652)
2014
17
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
18
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
19
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. (23635480)
2013
20
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
21
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. (23863526)
2013
22
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
23
Warthin tumor in an unusual site: a case report. (23715204)
2013
24
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. (23868565)
2013
25
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
26
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
27
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
28
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. (22576704)
2012
29
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
30
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
31
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
32
Warthin tumor arising from the minor salivary gland. (22976673)
2012
33
Adenocarcinoma arising in warthin tumor of the parotid gland. (23011833)
2012
34
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
35
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
36
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
37
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
38
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. (21493251)
2011
39
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. (21549478)
2011
40
Brucella melitensis infection within warthin tumor of the parotid gland. (21959459)
2011
41
Warthin tumor of the upper lip: an unusual location of a benign salivary gland tumor. (19189998)
2011
42
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
43
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
44
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
45
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
46
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
47
Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases. (19625134)
2010
48
Familial Warthin tumor: occurrence in monozygotic twins. (19944513)
2010
49
Warthin tumor: a curious entity--case reports and review of literature. (19434322)
2009
50
Mycobacterium tuberculosis infection within parotid gland Warthin tumor. (19098552)
2008

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.3CD44, HBEGF, KIT, TGFA, THY1, VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1somatic stem cell divisionGO:004810310.6KIT, TGFB2
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.5ERBB4, KIT
3regulation of cell motilityGO:200014510.5ERBB4, HBEGF
4mammary gland alveolus developmentGO:006074910.4ERBB4, TGFA
5peptidyl-tyrosine phosphorylationGO:001810810.2ERBB4, HBEGF, KIT
6positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.2ERBB4, KIT, TGFB2
7phosphatidylinositol phosphorylationGO:004685410.2ERBB4, HBEGF, KIT
8cell chemotaxisGO:006032610.2HBEGF, KIT, VCAM1
9phosphatidylinositol-mediated signalingGO:004801510.2ERBB4, HBEGF, KIT
10regulation of phosphatidylinositol 3-kinase signalingGO:001406610.2ERBB4, HBEGF, KIT
11positive regulation of CREB transcription factor activityGO:003279310.1CRTC1, CRTC3
12positive regulation of cell proliferationGO:00082849.5ERBB4, HBEGF, KIT, TGFA, TGFB2
13negative regulation of apoptotic processGO:00430669.0CD44, CEACAM5, ERBB4, KRT18, TGFA
14viral processGO:00160328.2CRTC1, CRTC3, KRT18, KRT7, VCAM1

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.1ERBB4, HBEGF, KIT
2cAMP response element binding protein bindingGO:000814010.1CRTC1, CRTC3
3protein tyrosine kinase activityGO:000471310.1ERBB4, HBEGF, KIT
4growth factor activityGO:000808310.1HBEGF, TGFA, TGFB2
5epidermal growth factor receptor bindingGO:000515410.0ERBB4, HBEGF, TGFA
6GPI anchor bindingGO:00342359.8CEACAM5, THY1
7Ras guanyl-nucleotide exchange factor activityGO:00050889.5ERBB4, HBEGF, KIT

Sources for Warthin Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet