MCID: WRT003
MIFTS: 33

Warthin Tumor malady

Categories: Rare diseases

Aliases & Classifications for Warthin Tumor

Aliases & Descriptions for Warthin Tumor:

Name: Warthin Tumor 50
Adenolymphoma 69

Classifications:



Summaries for Warthin Tumor

NIH Rare Diseases : 50 warthin tumor is a benign tumor of the salivary gland. the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. warthin tumors may increase in size over time, but few become cancerous. though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor. treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 9/8/2015

MalaCards based summary : Warthin Tumor, also known as adenolymphoma, is related to childhood mediastinal neurogenic tumor and conjunctival intraepithelial neoplasm. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are p70S6K Signaling and Development ERBB-family signaling. Affiliated tissues include salivary gland, lymph node and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and growth/size/body region

Related Diseases for Warthin Tumor

Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 childhood mediastinal neurogenic tumor 10.3 CRTC1 MAML2
2 conjunctival intraepithelial neoplasm 10.3 CRTC1 MAML2
3 uterus leiomyosarcoma 10.3 CD44 KIT
4 testis sarcoma 10.3 KIT KRT18
5 multidrug-resistant tuberculosis 10.2 CRTC1 KRT18 MAML2
6 proteus-like syndrome 10.2 KRT18 KRT7
7 kahrizi syndrome 10.2 KIT TGFA
8 nonossifying fibromyxoid tumor 10.2 KIT KRT7
9 lung combined type small cell carcinoma 10.1 CRTC1 KRT7 MAML2
10 paranasal sinus cancer 10.1 KIT KRT7
11 speech disorder 10.1 CEACAM5 KIT
12 dysembryoplastic neuroepithelial tumor 10.1 CD44 KRT18 KRT7
13 chronic granulomatous disease 10.1 KIT KRT18 KRT7
14 hypoglossal nerve disease 10.1 CEACAM5 KIT
15 middle ear adenocarcinoma 10.1 KIT KRT7
16 plasmodium ovale malaria 10.0 CRTC1 KIT KRT7 MAML2
17 lymphoma 10.0
18 osteosarcoma arising in bone paget's disease 10.0 CEACAM5 KRT7
19 synovitis 10.0 CEACAM5 KRT7
20 breast adenocarcinoma 10.0 CEACAM5 KRT7
21 laryngeal mucoepidermoid carcinoma 10.0 CEACAM5 KRT7
22 ovarian wilms' cancer 10.0 CEACAM5 KRT18
23 prostate lymphoma 10.0 CEACAM5 KRT7
24 tuberculosis 10.0
25 mucoepidermoid carcinoma 10.0
26 thyroiditis 10.0
27 sclerosing breast papilloma 10.0 CEACAM5 KRT7
28 waterhouse-friderichsen syndrome 10.0 CEACAM5 KRT7
29 main bronchus cancer 9.9 CEACAM5 KRT7
30 trophoblastic neoplasm 9.9 CEACAM5 KRT7
31 precursor t-lymphoblastic lymphoma/leukemia 9.9 CEACAM5 KIT
32 tubular adenocarcinoma 9.9 CEACAM5 KRT7
33 apocrine adenocarcinoma 9.9 CEACAM5 KRT7
34 cervicitis 9.9
35 cystadenoma 9.9
36 vulva basal cell carcinoma 9.9 CEACAM5 KIT KRT7
37 advanced sleep phase syndrome 9.9 CEACAM5 KIT KRT7
38 bartholin's gland adenoid cystic carcinoma 9.9 CEACAM5 KRT18 KRT7
39 endocrine organ benign neoplasm 9.9 CEACAM5 KIT KRT7
40 mitochondrial dna depletion syndrome 5 9.9 CEACAM5 KIT KRT7
41 muscular dystrophy-dystroglycanopathy , type b, 2 9.9 CD44 KIT KRT7 TGFA
42 breast granular cell tumor 9.8 CEACAM5 KRT7
43 deep angioma 9.8 CEACAM5 CRTC1 KRT7 MAML2
44 adenocarcinoma 9.8
45 female breast axillary tail cancer 9.8 CEACAM5 KRT7
46 malignant pleural solitary fibrous tumor 9.8 CD44 CEACAM5 KIT KRT7
47 proctitis 9.8 CD44 CEACAM5 KIT KRT7
48 vulvar angiokeratoma 9.7 CEACAM5 KRT7
49 mandibular cancer 9.7
50 histiocytosis 9.7

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to Warthin Tumor

Symptoms & Phenotypes for Warthin Tumor

GenomeRNAi Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 TGFB2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.53 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.53 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.53 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.53 TGFB2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.53 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.53 TGFB2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.53 TGFB2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 TGFB2 KRT18 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.53 TGFB2 KRT7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 KRT18
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 KRT7

MGI Mouse Phenotypes related to Warthin Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 KIT KRT18 TGFA TGFB2 VCAM1 CD44
2 muscle MP:0005369 9.7 KIT TGFA TGFB2 CD44 CRTC3 ERBB4
3 reproductive system MP:0005389 9.5 KIT TGFA TGFB2 VCAM1 CD44 CRTC1
4 respiratory system MP:0005388 9.1 KIT TGFB2 THY1 CD44 ERBB4 HBEGF

Drugs & Therapeutics for Warthin Tumor

Search Clinical Trials , NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

Anatomical Context for Warthin Tumor

MalaCards organs/tissues related to Warthin Tumor:

39
Salivary Gland, Lymph Node, Thyroid, Tongue, B Cells, T Cells, Lung

Publications for Warthin Tumor

Articles related to Warthin Tumor:

(show top 50) (show all 78)
id Title Authors Year
1
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. ( 27806841 )
2016
2
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. ( 27438374 )
2016
3
Incidental Warthin Tumor on Pertechnetate Scintigraphy. ( 27405035 )
2016
4
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. ( 28013343 )
2016
5
If cytology of Warthin tumor is accurate, can management be conservative? ( 27140020 )
2016
6
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. ( 26119391 )
2015
7
Synchronous parotid and nasopharyngeal Warthin tumor. ( 26315140 )
2015
8
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. ( 26170867 )
2015
9
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. ( 25992164 )
2015
10
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. ( 26169920 )
2015
11
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. ( 26634829 )
2015
12
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. ( 25816418 )
2015
13
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. ( 25149652 )
2014
14
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. ( 24791853 )
2014
15
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. ( 24880872 )
2014
16
Erratum to: Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. ( 25190011 )
2014
17
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. ( 24565204 )
2014
18
Warthin tumor in an unusual site: a case report. ( 23715204 )
2013
19
Letter to the editor. parotid Warthin tumor with mucous differentiation. ( 23529335 )
2013
20
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. ( 23635480 )
2013
21
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. ( 24121173 )
2013
22
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. ( 23868565 )
2013
23
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. ( 23579981 )
2013
24
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. ( 23863526 )
2013
25
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. ( 24350077 )
2013
26
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. ( 22576704 )
2012
27
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. ( 21591273 )
2012
28
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. ( 22976724 )
2012
29
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. ( 22227551 )
2012
30
Mycobacterial tuberculosis superimposed on a Warthin tumor. ( 22614566 )
2012
31
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. ( 22991990 )
2012
32
Adenocarcinoma arising in warthin tumor of the parotid gland. ( 23011833 )
2012
33
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. ( 22990554 )
2012
34
Warthin tumor arising from the minor salivary gland. ( 22976673 )
2012
35
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. ( 21877991 )
2011
36
Warthin tumor--morphological study of the stromal compartment. ( 22203940 )
2011
37
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. ( 21934225 )
2011
38
Brucella melitensis infection within warthin tumor of the parotid gland. ( 21959459 )
2011
39
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. ( 21493251 )
2011
40
Warthin tumor of the upper lip: an unusual location of a benign salivary gland tumor. ( 19189998 )
2011
41
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. ( 21549478 )
2011
42
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. ( 21769315 )
2011
43
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. ( 19340859 )
2010
44
Familial Warthin tumor: occurrence in monozygotic twins. ( 19944513 )
2010
45
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. ( 20027619 )
2010
46
Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases. ( 19625134 )
2010
47
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. ( 19969491 )
2010
48
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. ( 20090459 )
2010
49
Warthin tumor: a potential source of diagnostic error. ( 21119475 )
2010
50
Warthin tumor: a curious entity--case reports and review of literature. ( 19434322 )
2009

Variations for Warthin Tumor

Expression for Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for Warthin Tumor

GO Terms for Warthin Tumor

Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.1 CD44 HBEGF KIT TGFA THY1 VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.77 CD44 CEACAM5 ERBB4 KRT18 TGFA
2 peptidyl-tyrosine phosphorylation GO:0018108 9.76 ERBB4 HBEGF KIT
3 phosphatidylinositol-mediated signaling GO:0048015 9.72 ERBB4 HBEGF KIT
4 single organismal cell-cell adhesion GO:0016337 9.7 CD44 THY1 VCAM1
5 phosphatidylinositol phosphorylation GO:0046854 9.67 ERBB4 HBEGF KIT
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 CD44 HBEGF TGFA
7 regulation of cell motility GO:2000145 9.59 ERBB4 HBEGF
8 mammary gland alveolus development GO:0060749 9.58 ERBB4 TGFA
9 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.58 ERBB4 HBEGF KIT
10 energy homeostasis GO:0097009 9.57 CRTC1 CRTC3
11 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.56 ERBB4 KIT
12 positive regulation of cell proliferation GO:0008284 9.55 ERBB4 HBEGF KIT TGFA TGFB2
13 positive regulation of CREB transcription factor activity GO:0032793 9.54 CRTC1 CRTC3
14 negative regulation of ERBB signaling pathway GO:1901185 9.51 ERBB4 HBEGF
15 cell chemotaxis GO:0060326 9.5 HBEGF KIT VCAM1
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 CD44 THY1
17 somatic stem cell division GO:0048103 9.43 KIT TGFB2
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 ERBB4 KIT TGFB2
19 signal transduction by protein phosphorylation GO:0023014 9.13 ERBB4 KIT TGFB2
20 viral process GO:0016032 9.02 CRTC1 CRTC3 KRT18 KRT7 VCAM1

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.61 ERBB4 HBEGF KIT
2 growth factor activity GO:0008083 9.58 HBEGF TGFA TGFB2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 ERBB4 HBEGF KIT
4 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.32 ERBB4 KIT
5 cAMP response element binding protein binding GO:0008140 9.26 CRTC1 CRTC3
6 GPI anchor binding GO:0034235 9.16 CEACAM5 THY1
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 ERBB4 HBEGF KIT
8 epidermal growth factor receptor binding GO:0005154 8.8 ERBB4 HBEGF TGFA

Sources for Warthin Tumor

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