Aliases & Classifications for Warthin Tumor

MalaCards integrated aliases for Warthin Tumor:

Name: Warthin Tumor 50
Adenolymphoma 69

Classifications:



Summaries for Warthin Tumor

NIH Rare Diseases : 50 warthin tumor is a benign tumor of the salivary gland. the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. warthin tumors may increase in size over time, but few become cancerous. though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor. treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 9/8/2015

MalaCards based summary : Warthin Tumor, also known as adenolymphoma, is related to laryngeal mucoepidermoid carcinoma and eccrine papillary adenoma. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are p70S6K Signaling and NF-kappaB Signaling. Affiliated tissues include salivary gland, lymph node and thyroid, and related phenotypes are growth/size/body region and muscle

Related Diseases for Warthin Tumor

Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 laryngeal mucoepidermoid carcinoma 10.7 CRTC1 MAML2
2 eccrine papillary adenoma 10.7 CRTC1 MAML2
3 breast leiomyosarcoma 10.6 CD44 KIT
4 pancreatic serous cystadenoma 10.6 CRTC1 MAML2
5 testis rhabdomyosarcoma 10.5 KIT KRT18
6 rete testis neoplasm 10.5 CRTC1 MAML2
7 plasmodium ovale malaria 10.4 CRTC1 KIT MAML2
8 fallopian tube transitional cell carcinoma 10.4 CRTC1 KRT18 MAML2
9 extragonadal nonseminomatous germ cell tumor 10.3 KIT KRT18
10 vaginal adenoma 10.3 CRTC1 MAML2
11 spiradenoma 10.3 ERBB4 KIT
12 wilms tumor 6 10.3 KIT TGFA
13 auditory system disease 10.3 CD44 HBEGF
14 riboflavin transporter deficiency 10.2 CD44 VCAM1
15 liver inflammatory pseudotumor 10.1 CEACAM5 KIT
16 hunter carpenter macdonald syndrome 10.1 CRTC1 CRTC3
17 hypoglossal nerve disease 10.1 CEACAM5 KIT
18 trachea adenoid cystic carcinoma 10.0 CEACAM5 KRT18
19 superficial basal cell carcinoma 10.0 CEACAM5 KIT
20 lymphoma 10.0
21 mucoepidermoid carcinoma 10.0
22 gastric papillary adenocarcinoma 10.0 CEACAM5 KIT
23 ovarian wilms' cancer 10.0 CEACAM5 KRT18
24 sphenoid sinus squamous cell carcinoma 10.0 CEACAM5 KIT
25 tuberculosis 10.0
26 thyroiditis 10.0
27 urethra clear cell adenocarcinoma 9.9 CEACAM5 KRT18
28 mucoepidermoid thyroid carcinoma 9.9 CEACAM5 CRTC1 MAML2
29 cervicitis 9.9
30 cystadenoma 9.9
31 adenocarcinoma 9.8
32 gallbladder cancer 9.8 CD44 CEACAM5 KIT
33 brown-vialetto-van laere syndrome 9.8 CD44 CEACAM5 KIT
34 hodgkin lymphoma 9.7
35 b-cell lymphomas 9.7
36 diffuse large b-cell lymphoma 9.7
37 mantle cell lymphoma 9.7
38 peripheral t-cell lymphoma 9.7
39 nasopharyngitis 9.7
40 necrotizing sialometaplasia 9.7
41 squamous cell carcinoma 9.7
42 thyroid cancer 9.7
43 mandibular cancer 9.7
44 histiocytosis 9.7
45 pleomorphic adenoma 9.7
46 adenoma 9.7
47 actinomycosis 9.7
48 tongue cancer 9.7
49 nodular lymphocyte predominant hodgkin lymphoma 9.7
50 urethral villous adenoma 9.6 CEACAM5 KIT

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to Warthin Tumor

Symptoms & Phenotypes for Warthin Tumor

MGI Mouse Phenotypes related to Warthin Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 CD44 CRTC1 CRTC3 HBEGF KIT KRT18
2 muscle MP:0005369 9.7 CRTC3 ERBB4 HBEGF KIT TGFA TGFB2
3 reproductive system MP:0005389 9.5 CD44 CRTC1 ERBB4 KIT TGFA TGFB2
4 respiratory system MP:0005388 9.1 CD44 ERBB4 HBEGF KIT TGFB2 THY1

Drugs & Therapeutics for Warthin Tumor

Search Clinical Trials , NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

Anatomical Context for Warthin Tumor

MalaCards organs/tissues related to Warthin Tumor:

39
Salivary Gland, Lymph Node, Thyroid, Tongue, B Cells, T Cells, Lung

Publications for Warthin Tumor

Articles related to Warthin Tumor:

(show top 50) (show all 81)
id Title Authors Year
1
Warthin Tumor-Like Mucoepidermoid Carcinoma. ( 28793830 )
2017
2
Extracapsular dissection for Warthin tumor in the tail of parotid gland. ( 28446044 )
2017
3
Letter to the Editor: Multinucleated cells in parotid Warthin tumor: a potential diagnostic pitfall? ( 28174818 )
2016
4
If cytology of Warthin tumor is accurate, can management be conservative? ( 27140020 )
2016
5
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. ( 28013343 )
2016
6
Incidental Warthin Tumor on Pertechnetate Scintigraphy. ( 27405035 )
2016
7
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. ( 27438374 )
2016
8
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. ( 27806841 )
2016
9
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. ( 26170867 )
2015
10
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. ( 25992164 )
2015
11
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. ( 26169920 )
2015
12
Synchronous parotid and nasopharyngeal Warthin tumor. ( 26315140 )
2015
13
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. ( 26634829 )
2015
14
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. ( 26119391 )
2015
15
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. ( 25816418 )
2015
16
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. ( 25149652 )
2014
17
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. ( 24880872 )
2014
18
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. ( 24565204 )
2014
19
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. ( 24791853 )
2014
20
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. ( 23579981 )
2013
21
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. ( 23635480 )
2013
22
Letter to the editor. parotid Warthin tumor with mucous differentiation. ( 23529335 )
2013
23
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. ( 24350077 )
2013
24
Warthin tumor in an unusual site: a case report. ( 23715204 )
2013
25
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. ( 23868565 )
2013
26
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. ( 24121173 )
2013
27
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. ( 23863526 )
2013
28
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. ( 21591273 )
2012
29
Adenocarcinoma arising in warthin tumor of the parotid gland. ( 23011833 )
2012
30
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. ( 22991990 )
2012
31
Warthin tumor arising from the minor salivary gland. ( 22976673 )
2012
32
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. ( 22976724 )
2012
33
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. ( 22576704 )
2012
34
Mycobacterial tuberculosis superimposed on a Warthin tumor. ( 22614566 )
2012
35
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. ( 22227551 )
2012
36
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. ( 22990554 )
2012
37
Warthin tumor of the upper lip: an unusual location of a benign salivary gland tumor. ( 19189998 )
2011
38
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. ( 21934225 )
2011
39
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. ( 21493251 )
2011
40
Brucella melitensis infection within warthin tumor of the parotid gland. ( 21959459 )
2011
41
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. ( 21877991 )
2011
42
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. ( 21549478 )
2011
43
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. ( 21769315 )
2011
44
Warthin tumor--morphological study of the stromal compartment. ( 22203940 )
2011
45
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. ( 19340859 )
2010
46
Familial Warthin tumor: occurrence in monozygotic twins. ( 19944513 )
2010
47
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. ( 20027619 )
2010
48
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. ( 19969491 )
2010
49
Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases. ( 19625134 )
2010
50
Warthin tumor: a potential source of diagnostic error. ( 21119475 )
2010

Variations for Warthin Tumor

Expression for Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for Warthin Tumor

GO Terms for Warthin Tumor

Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.13 CEACAM5 ERBB4 TGFA
2 cell surface GO:0009986 9.1 CD44 HBEGF KIT TGFA THY1 VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.88 CRTC1 CRTC3 KRT18 VCAM1
2 protein autophosphorylation GO:0046777 9.77 ERBB4 KIT THY1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.76 ERBB4 HBEGF KIT
4 phosphatidylinositol-mediated signaling GO:0048015 9.71 ERBB4 HBEGF KIT
5 single organismal cell-cell adhesion GO:0016337 9.69 CD44 THY1 VCAM1
6 phosphatidylinositol phosphorylation GO:0046854 9.67 ERBB4 HBEGF KIT
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 CD44 HBEGF TGFA
8 regulation of cell motility GO:2000145 9.6 ERBB4 HBEGF
9 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.58 ERBB4 HBEGF KIT
10 mammary gland alveolus development GO:0060749 9.57 ERBB4 TGFA
11 energy homeostasis GO:0097009 9.56 CRTC1 CRTC3
12 positive regulation of CREB transcription factor activity GO:0032793 9.55 CRTC1 CRTC3
13 positive regulation of cell proliferation GO:0008284 9.55 ERBB4 HBEGF KIT TGFA TGFB2
14 negative regulation of ERBB signaling pathway GO:1901185 9.52 ERBB4 HBEGF
15 cell chemotaxis GO:0060326 9.5 HBEGF KIT VCAM1
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 CD44 THY1
17 somatic stem cell division GO:0048103 9.43 KIT TGFB2
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 ERBB4 KIT TGFB2
19 negative regulation of apoptotic process GO:0043066 9.35 CD44 CEACAM5 ERBB4 KRT18 TGFA
20 cell-cell adhesion GO:0098609 9.07 KRT18
21 signal transduction by protein phosphorylation GO:0023014 8.8 ERBB4 KIT TGFB2

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.61 ERBB4 HBEGF KIT
2 growth factor activity GO:0008083 9.58 HBEGF TGFA TGFB2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 ERBB4 HBEGF KIT
4 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.32 ERBB4 KIT
5 cAMP response element binding protein binding GO:0008140 9.26 CRTC1 CRTC3
6 GPI anchor binding GO:0034235 9.16 CEACAM5 THY1
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 ERBB4 HBEGF KIT
8 epidermal growth factor receptor binding GO:0005154 8.8 ERBB4 HBEGF TGFA

Sources for Warthin Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....