MCID: WRT003
MIFTS: 33

Warthin Tumor malady

Rare diseases, Immune diseases, Cancer diseases categories

Aliases & Classifications for Warthin Tumor

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Sources:
45NIH Rare Diseases, 65UMLS, 47Novoseek
See all sources

Aliases & Descriptions for Warthin Tumor:

Name: Warthin Tumor 45
Adenolymphoma 65 47
 
Papillary Cystadenoma Lymphomatosum 45


Classifications:



Summaries for Warthin Tumor

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NIH Rare Diseases:45 Warthin tumor is a benign tumor of the salivary gland. the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. warthin tumors may increase in size over time, but few become cancerous. though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor. treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 9/8/2015

MalaCards based summary: Warthin Tumor, also known as adenolymphoma, is related to mikulicz disease and mucoepidermoid carcinoma. An important gene associated with Warthin Tumor is MAML2 (Mastermind-Like Transcriptional Coactivator 2), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cell adhesion_ECM remodeling. Affiliated tissues include salivary gland, lymph node and thyroid, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Related Diseases for Warthin Tumor

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Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1mikulicz disease30.0CRTC1, KIT, KRT7, MAML2
2mucoepidermoid carcinoma10.4
3tuberculosis10.4
4cystadenoma10.4
5cervicitis10.4
6thyroiditis10.4
7liposarcoma of bone10.3CRTC1, MAML2
8uterine corpus adenosarcoma10.3CRTC1, MAML2
9adenocarcinoma10.3
10histidine metabolism disease10.3CRTC1, MAML2
11cervical benign neoplasm10.2CRTC1, MAML2
12paraphimosis10.2CRTC1, KRT18, MAML2
13dyschromatosis universalis10.2KRT18, KRT7
14pagod syndrome10.2ERBB4, KRT7
15multilocular cystic renal cell carcinoma10.1KRT18, KRT7
16gilbert syndrome10.1CD44, HBEGF
17hodgkin lymphoma10.1
18b-cell lymphomas10.1
19diffuse large b-cell lymphoma10.1
20peripheral t-cell lymphoma10.1
21mandibular cancer10.1
22langerhans-cell histiocytosis10.1
23necrotizing sialometaplasia10.1
24pleomorphic adenoma10.1
25nasopharyngitis10.1
26actinomycosis10.1
27adenoma10.1
28histiocytosis10.1
29thyroid cancer10.1
30tongue cancer10.1
31nodular lymphocyte predominant hodgkin lymphoma10.1
32seminoma10.1KRT18, KRT7
33hypereosinophilic syndrome, idiopathic, resistant to imatinib10.1KIT, TGFA
34placental choriocarcinoma10.1CRTC1, KRT7, MAML2
35anus rhabdomyosarcoma10.1CRTC1, KRT7, MAML2
36papillary carcinoma10.1
37junctional epidermolysis bullosa10.1CRTC1, KRT7, MAML2
38bowenoid papulosis10.1KRT7, TGFB2
39synovial angioma10.1KIT, KRT7
40chromosomal disease10.1KIT, KRT7
41rhizomelic dysplasia patterson lowry type10.0CD44, VCAM1
42salivary gland disease10.0CRTC1, CRTC3, MAML2
43follicular basal cell carcinoma10.0KIT, KRT7
44papillary follicular thyroid adenocarcinoma10.0KRT18, KRT7
45kidney cancer10.0KIT, KRT7
46mast cell disease10.0CD44, KIT
47pulmonary neuroendocrine tumor10.0KIT, KRT18, KRT7
48mixed epithelial tumor of ovary9.9KIT, KRT7
49thymus gland disease9.9KIT, THY1
50kidney disease9.7CD44, KIT, KRT7, TGFA

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms for Warthin Tumor

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Drugs & Therapeutics for Warthin Tumor

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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MalaCards organs/tissues related to Warthin Tumor:

33
Salivary gland, Lymph node, Thyroid, Tongue, B cells, T cells, Lung

Animal Models for Warthin Tumor or affiliated genes

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MGI Mouse Phenotypes related to Warthin Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CD44, ERBB4, HBEGF, KIT, TGFB2, THY1
2MP:00053798.3CD44, CRTC1, ERBB4, KIT, TGFA, TGFB2
3MP:00053698.0CD44, CRTC3, ERBB4, HBEGF, KIT, TGFA
4MP:00053857.8CD44, CRTC1, ERBB4, HBEGF, KIT, TGFA
5MP:00053897.7CD44, CRTC1, ERBB4, KIT, TGFA, TGFB2
6MP:00053787.0CD44, CRTC1, CRTC3, HBEGF, KIT, KRT18

Publications for Warthin Tumor

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Articles related to Warthin Tumor:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Synchronous parotid and nasopharyngeal Warthin tumor. (26315140)
2015
2
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. (26119391)
2015
3
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. (25992164)
2015
4
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. (25816418)
2015
5
Erratum to: Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (25190011)
2014
6
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. (24791853)
2014
7
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (24565204)
2014
8
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. (25149652)
2014
9
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. (24880872)
2014
10
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
11
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. (23863526)
2013
12
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
13
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
14
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
15
Warthin tumor in an unusual site: a case report. (23715204)
2013
16
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
17
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
18
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
19
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
20
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
21
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
22
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
23
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
24
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
25
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. (21549478)
2011
26
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
27
Brucella melitensis infection within warthin tumor of the parotid gland. (21959459)
2011
28
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
29
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
30
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
31
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
32
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
33
Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. (19031731)
2008
34
Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. (15994480)
2005
35
Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. (16000851)
2005
36
Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate. (16012309)
2005
37
Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation. (15313720)
2004
38
Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. (12811857)
2003
39
Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature. (11026102)
2000
40
Follicle center lymphoma and Warthin tumor involving the same anatomic site. Report of two cases and review of the literature. (10631864)
2000
41
Quiz case 2. Warthin tumor. (10555703)
1999
42
Warthin tumor. A new hypothesis concerning its development. (9474616)
1998
43
Molecular characterization of Warthin tumor. (9619676)
1998
44
An unusual neck mass: the Warthin tumor. (9581198)
1998
45
Warthin tumor of the lacrimal gland. (9402842)
1997
46
Aspiration cytology features of the warthin tumor-like variant of papillary thyroid carcinoma. A report of two cases. (9990276)
1997
47
Warthin tumor of the parotid gland: MR-pathologic correlation. (8427092)
1993
48
Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. (7281493)
1981
49
Letter: Warthin tumor in two brothers. (988997)
1976
50
Papillary cystadenoma lymphomatosum (Warthin tumor). (5639487)
1968

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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Search GEO for disease gene expression data for Warthin Tumor.

Pathways for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2CD44, KIT, THY1, VCAM1
2basolateral plasma membraneGO:00163238.2CD44, CEACAM5, ERBB4, TGFA
3cell surfaceGO:00099868.2CD44, HBEGF, KIT, TGFA, THY1, VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.5ERBB4, KIT
2somatic stem cell divisionGO:004810310.4KIT, TGFB2
3positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.4ERBB4, KIT
4signal transduction by protein phosphorylationGO:002301410.1ERBB4, KIT, TGFB2
5positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.0ERBB4, KIT, TGFB2
6phosphatidylinositol-mediated signalingGO:00480159.9ERBB4, HBEGF, KIT
7mammary gland alveolus developmentGO:00607499.9ERBB4, TGFA
8positive regulation of CREB transcription factor activityGO:00327939.9CRTC1, CRTC3
9protein autophosphorylationGO:00467779.6ERBB4, KIT, THY1
10single organismal cell-cell adhesionGO:00163379.5CD44, THY1, VCAM1
11epidermal growth factor receptor signaling pathwayGO:00071739.0ERBB4, HBEGF, KIT, TGFA
12positive regulation of cell proliferationGO:00082848.8ERBB4, HBEGF, KIT, TGFA, TGFB2
13viral processGO:00160328.5CRTC1, CRTC3, KRT18, KRT7, VCAM1
14negative regulation of apoptotic processGO:00430668.4CD44, CEACAM5, ERBB4, KRT18, TGFA

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.2ERBB4, KIT
2epidermal growth factor receptor bindingGO:00051549.7ERBB4, HBEGF, TGFA
3cAMP response element binding protein bindingGO:00081409.4CRTC1, CRTC3
4GPI anchor bindingGO:00342359.4CEACAM5, THY1
5growth factor activityGO:00080839.1HBEGF, TGFA, TGFB2

Sources for Warthin Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet