MCID: WRT003
MIFTS: 30

Warthin Tumor malady

Rare diseases, Immune diseases, Cancer diseases categories

Summaries for Warthin Tumor

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Warthin tumor is an unusual growth of cells (tumor) in a salivary gland.  the first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin.  warthin tumors may increase in size over time, but few become cancerous.  though the cause is currently unknown, smoking is believed to increase the chance of developing warthin tumor.  treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time. last updated: 10/10/2012

MalaCards: Warthin Tumor, also known as papillary cystadenoma lymphomatosum, is related to mucoepidermoid carcinoma and necrotizing sialometaplasia. An important gene associated with Warthin Tumor is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are HTLV-I infection and Glucose / Energy Metabolism. Affiliated tissues include salivary gland, lymph node and thyroid, and related mouse phenotype adipose tissue.

Aliases & Classifications for Warthin Tumor

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

warthin tumor 44
papillary cystadenoma lymphomatosum 44
adenolymphoma 63


Related Diseases for Warthin Tumor

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to warthin tumor

Symptoms for Warthin Tumor

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Drugs & Therapeutics for Warthin Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Warthin Tumor

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Anatomical Context for Warthin Tumor

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34MalaCards
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MalaCards organs/tissues related to Warthin Tumor:

34
Salivary gland, Lymph node, Thyroid, Lung, T cells, Tongue

Animal Models for Warthin Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Warthin Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8NOS2, CRTC1, CRTC3

Publications for Warthin Tumor

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53PubMed
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Articles related to Warthin Tumor:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (24121173)
2013
2
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. (23863526)
2013
3
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. (23579981)
2013
4
Letter to the editor. parotid Warthin tumor with mucous differentiation. (23529335)
2013
5
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. (24350077)
2013
6
Warthin tumor in an unusual site: a case report. (23715204)
2013
7
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. (23868565)
2013
8
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. (21591273)
2012
9
Mycobacterial tuberculosis superimposed on a Warthin tumor. (22614566)
2012
10
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. (22976724)
2012
11
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. (22990554)
2012
12
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. (22227551)
2012
13
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. (22991990)
2012
14
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. (22576704)
2012
15
Warthin tumor arising from the minor salivary gland. (22976673)
2012
16
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
17
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. (21877991)
2011
18
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. (21934225)
2011
19
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. (21549478)
2011
20
Warthin tumor--morphological study of the stromal compartment. (22203940)
2011
21
Brucella melitensis infection within warthin tumor of the parotid gland. (21959459)
2011
22
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. (19340859)
2010
23
The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. (19969491)
2010
24
Warthin tumor: a potential source of diagnostic error. (21119475)
2010
25
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. (20090459)
2010
26
Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. (20027619)
2010
27
Familial Warthin tumor: occurrence in monozygotic twins. (19944513)
2010
28
Warthin tumor: a curious entity--case reports and review of literature. (19434322)
2009
29
Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. (19031731)
2008
30
Mycobacterium tuberculosis infection within parotid gland Warthin tumor. (19098552)
2008
31
High risk for bilateral Warthin tumor in heavy smokers--review of 185 cases. (17050316)
2006
32
Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. (15994480)
2005
33
Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. (16000851)
2005
34
Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate. (16012309)
2005
35
Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation. (15313720)
2004
36
Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. (12811857)
2003
37
False diagnosis caused by Warthin tumor of the parotid gland combined with actinomycosis. (12544220)
2003
38
Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature. (11026102)
2000
39
Follicle center lymphoma and Warthin tumor involving the same anatomic site. Report of two cases and review of the literature. (10631864)
2000
40
Quiz case 2. Warthin tumor. (10555703)
1999
41
Warthin tumor. A new hypothesis concerning its development. (9474616)
1998
42
Molecular characterization of Warthin tumor. (9619676)
1998
43
An unusual neck mass: the Warthin tumor. (9581198)
1998
44
Warthin tumor of the lacrimal gland. (9402842)
1997
45
Aspiration cytology features of the warthin tumor-like variant of papillary thyroid carcinoma. A report of two cases. (9990276)
1997
46
Warthin tumor of the parotid gland: MR-pathologic correlation. (8427092)
1993
47
Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. (7281493)
1981
48
Warthin tumor. B-lymphocytes within the lymphoid infiltrate. (326225)
1977
49
Letter: Warthin tumor in two brothers. (988997)
1976
50
Papillary cystadenoma lymphomatosum (Warthin tumor). (5639487)
1968

Variations for Warthin Tumor

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Expression for genes affiliated with Warthin Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Warthin Tumor

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Pathways for genes affiliated with Warthin Tumor

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51PathCards, 31KEGG, 5Cell Signaling Technology
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Pathways related to Warthin Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CRTC1, CRTC3
29.3CRTC1, CRTC3

Compounds for genes affiliated with Warthin Tumor

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GO Terms for genes affiliated with Warthin Tumor

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17Gene Ontology
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Cellular components related to Warthin Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.0NOS2, CRTC1, CRTC3, MAML2

Biological processes related to Warthin Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homotetramerizationGO:0512899.3CRTC1, CRTC3
2positive regulation of CREB transcription factor activityGO:0327939.0CRTC1, CRTC3

Molecular functions related to Warthin Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP response element binding protein bindingGO:0081409.3CRTC1, CRTC3

Products for genes affiliated with Warthin Tumor

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Sources for Warthin Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet