MCID: WSR001
MIFTS: 22

Was-Related Disorders malady

Summaries for Was-Related Disorders

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19GeneReviews, 33MalaCards
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MalaCards: Was-Related Disorders is related to wiskott-aldrich syndrome and joubert syndrome. An important gene associated with Was-Related Disorders is WAS (Wiskott-Aldrich syndrome), and among its related pathways is Non-integrin membrane-ECM interactions. The compound hpaii have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and growth/size.

GeneReviews summary for was

Aliases & Classifications for Was-Related Disorders

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19GeneReviews, 20GeneTests
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Aliases & Descriptions:

was-related disorders 19 20


Related Diseases for Was-Related Disorders

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Was-Related Disorders:



Diseases related to was-related disorders

Clinical Features for Was-Related Disorders

Drugs & Therapeutics for Was-Related Disorders

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Was-Related Disorders

Drug clinical trials:

Search ClinicalTrials for Was-Related Disorders

Search NIH Clinical Center for Was-Related Disorders

Search CenterWatch for Was-Related Disorders

Genetic Tests for Was-Related Disorders

Sources:
20GeneTests
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Genetic tests related to Was-Related Disorders:

id Genetic test Affiliating Genes
1 Was-related Disorders20 WAS

Anatomical Context for Was-Related Disorders

Animal Models for Was-Related Disorders or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Was-Related Disorders:

37 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.7SALL4, FMR1, RPGRIP1L, COL6A1, C10orf2, IRF6
2MP:000537811.7IRF6, SALL4, NSDHL, FMR1, RPGRIP1L, ARX
3MP:001076811.7IRF6, SALL4, NSDHL, RPGRIP1L, C10orf2, ARX
4MP:000363111.5RPGRIP1L, FMR1, NSDHL, SALL4, ARX, MECP2
5MP:000539111.5CEP290, RPGRIP1L, FMR1, NSDHL, SALL4, NPHP1
6MP:000539011.4RPGRIP1L, NSDHL, SALL4, IRF6, WAS, MECP2
7MP:000538911.3FMR1, SALL4, NPHP1, ARX, MECP2, FLNA
8MP:000538511.3C10orf2, RPGRIP1L, NSDHL, SALL4, FLNA, POLG
9MP:000538211.2RPGRIP1L, SALL4, IRF6, MECP2, FLNA, MKKS
10MP:000536711.1RPGRIP1L, SALL4, NPHP1, WAS, AHI1, TMEM67
11MP:000537911.1RPGRIP1L, FMR1, NPHP1, WAS, ARX, MECP2
12MP:000538011.0C10orf2, RPGRIP1L, NSDHL, SALL4, MECP2, POLG
13MP:000537710.9SALL4, IRF6, MECP2, POLG, MKKS
14MP:000537110.8MKKS, IRF6, SALL4, NSDHL, RPGRIP1L
15MP:000538110.8SALL4, IRF6, WAS, FLNA, POLG, TMEM67
16MP:000538610.7FMR1, NSDHL, SALL4, ARX, MECP2, FLNA

Publications for Was-Related Disorders

Genetic Variations for Was-Related Disorders

Expression for genes affiliated with Was-Related Disorders

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Was-Related Disorders

Search GEO for disease gene expression data for Was-Related Disorders.

Pathways for genes affiliated with Was-Related Disorders

Sources:
54Reactome, 30KEGG
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Pathways related to Was-Related Disorders according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6COL6A1, COL6A2

Compounds for genes affiliated with Was-Related Disorders

Sources:
45Novoseek
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Compounds related to Was-Related Disorders according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hpaii4510.6MECP2, FMR1

GO Terms for genes affiliated with Was-Related Disorders

Sources:
16Gene Ontology
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Cellular components related to Was-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule basal bodyGO:00593210.9CEP290, TMEM67, AHI1, RPGRIP1L
2centrosomeGO:00581310.8RPGRIP1L, MKKS, AHI1, TMEM67, CEP290
3TCTN-B9D complexGO:03603810.8CEP290, TMEM67, AHI1
4photoreceptor connecting ciliumGO:03239110.6CEP290, NPHP1
5cell-cell junctionGO:00591110.6AHI1, NPHP1, RPGRIP1L
6heterochromatinGO:00079210.3MECP2, SALL4

Biological processes related to Was-Related Disorders according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cilium assemblyGO:04238411.1CEP290, RPGRIP1L, FLNA, MKKS, AHI1, TMEM67
2cilium morphogenesisGO:06027110.9CEP290, TMEM67, AHI1, MKKS
3photoreceptor cell outer segment organizationGO:03584510.7NPHP1, AHI1
4mitochondrial DNA replicationGO:00626410.7POLG, C10orf2
5protein heterotrimerizationGO:07020810.6COL6A1, COL6A2
6cerebellum developmentGO:02154910.6MECP2, RPGRIP1L
7hindbrain developmentGO:03090210.5AHI1, CEP290
8establishment or maintenance of cell polarityGO:00716310.3CEP290, RPGRIP1L

Molecular functions related to Was-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4CEP290, RPGRIP1L, FMR1, IRF6, NPHP1, WAS

Products for genes affiliated with Was-Related Disorders

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Was-Related Disorders

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet