MCID: WSR001
MIFTS: 13

Was-Related Disorders

Categories: Genetic diseases

Aliases & Classifications for Was-Related Disorders

MalaCards integrated aliases for Was-Related Disorders:

Name: Was-Related Disorders 23 24

Characteristics:

GeneReviews:

23
Penetrance Penetrance is complete in males with a was pathogenic variant...

Classifications:



Summaries for Was-Related Disorders

MalaCards based summary : Was-Related Disorders is related to thrombocytopenia, x-linked and wiskott-aldrich syndrome. An important gene associated with Was-Related Disorders is WAS (Wiskott-Aldrich Syndrome). The drugs Benzocaine and Rocuronium have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and heart.

GeneReviews: NBK1178

Related Diseases for Was-Related Disorders

Diseases related to Was-Related Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 thrombocytopenia, x-linked 10.9
2 wiskott-aldrich syndrome 10.7

Symptoms & Phenotypes for Was-Related Disorders

Drugs & Therapeutics for Was-Related Disorders

Drugs for Was-Related Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
3
Lactulose Approved Phase 4 4618-18-2 11333
4 tannic acid Approved, Nutraceutical Phase 4
5 Analgesics Phase 4,Phase 3
6 Neuromuscular Agents Phase 4
7 Neuromuscular Blocking Agents Phase 4
8 Neuromuscular Nondepolarizing Agents Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 3
10 Phosphodiesterase 5 Inhibitors Phase 4
11 Vasodilator Agents Phase 4
12 Gastrointestinal Agents Phase 4
13 Phosphodiesterase Inhibitors Phase 4
14 Sildenafil Citrate Phase 4 171599-83-0
15 Citrate Nutraceutical Phase 4
16
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
17
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
18
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
19
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
20 Adrenergic Agents Phase 3
21 Adrenergic Agonists Phase 3
22 Adrenergic alpha-2 Receptor Agonists Phase 3
23 Adrenergic alpha-Agonists Phase 3
24 Analgesics, Non-Narcotic Phase 3
25 Anesthetics Phase 3
26 Central Nervous System Depressants Phase 3
27 Hypnotics and Sedatives Phase 3
28 Neurotransmitter Agents Phase 3
29 calcium channel blockers Phase 3
30 Calcium, Dietary Phase 3
31 Anticonvulsants Phase 3
32 Diuretics, Potassium Sparing Phase 3
33 Excitatory Amino Acid Antagonists Phase 3
34 Excitatory Amino Acids Phase 3
35 Sodium Channel Blockers Phase 3
36 Albumin-Bound Paclitaxel Phase 2, Phase 3
37
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
38
Gemcitabine Approved Phase 2 95058-81-4 60750
39
Betamethasone Approved, Vet_approved Phase 2 378-44-9 9782
40
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
41
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
42 Anti-Infective Agents Phase 2
43 Antimetabolites Phase 2
44 Antimetabolites, Antineoplastic Phase 2
45 Antimitotic Agents Phase 2
46 Antiviral Agents Phase 2
47 Immunosuppressive Agents Phase 2
48 Protein Kinase Inhibitors Phase 2
49 Anti-Asthmatic Agents Phase 2
50 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 24)

id Name Status NCT ID Phase Drugs
1 Influence of Profound Muscle Relaxation on Muscle Trauma and Postoperative Pulmonary Function Unknown status NCT01804933 Phase 4 profound neuromuscular blockade
2 Effect of Lactulose on Minimal Hepatic Encephalopathy and Health-Related Quality of Life Completed NCT00375375 Phase 4 Lactulose
3 A Study to Evaluate Self-esteem and Relationships in Males With Erectile Dysfuntion Completed NCT00648596 Phase 4 sildenafil;placebo
4 Dexmedetomidine on Postoperative Delirium and Quality of Recovery in Geriatric Patients Unknown status NCT01283412 Phase 3 Placebo;Dexmedetomidine
5 Lamotrigine for Symptoms of Geriatric Bipolar Depression Completed NCT00621842 Phase 3 Lamotrigine regular tablet formulation;Lamotrigine novel formulation
6 An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK) Recruiting NCT02856230 Phase 2, Phase 3
7 Randomized Phase 2 Study of 3 Therapeutic Modalities in PS 2/3 Patients With NSCLC Stage IIIB/IV Completed NCT00198393 Phase 2 Gefitinib;gemcitabine;Docetaxel
8 Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells Not yet recruiting NCT03279796 Phase 2 Compound betamethasone
9 The Effect of Blood Flow in the Maturing Arteriovenous Access for Hemodialysis on the Development of Pulmonary Hypertension. Completed NCT00739375 Phase 1
10 Effect of Intensive Low Sodium Restriction on Glomerular Infiltration Rate in Chronic Kidney Disease Unknown status NCT02519894
11 Development and Prevention of Pulmonary Hypertension in Systemic Sclerosis Unknown status NCT01840748
12 Immune Response to Influenza Vaccine in HIV-Infected Individuals Completed NCT00069914
13 Atherosclerosis and Omega-3 Fatty Acids in Alaskan Natives Completed NCT00005236
14 Prevalence of Pathologic Gambling in the Workforce: a Cross-sectional Study in Brittany, France Completed NCT03317054
15 Prospective Clinical Evaluation of Periodontal Response to Different Prosthetic Margin Design Completed NCT02276586
16 Comparison of Changes of Inflammatory Proteins in Aqueous Humour of Subjects Treated With Avastin vs Lucentis Completed NCT01760746
17 Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia Completed NCT01783093
18 Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy Completed NCT02820051 Midazolam;Propofol;Nalbuphine;Lidocaine
19 Effects of Diet on Reflux and Dyspepsia Completed NCT02425553
20 Obestatin Change in Distal Gastrectomy Completed NCT00822718
21 Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions Completed NCT02122276
22 Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training Recruiting NCT02656355
23 Optimal Site for Rapid Urease Test in the Stomach Recruiting NCT02945137
24 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Not yet recruiting NCT02698930 dexmedetomidine;Normal saline

Search NIH Clinical Center for Was-Related Disorders

Genetic Tests for Was-Related Disorders

Genetic tests related to Was-Related Disorders:

id Genetic test Affiliating Genes
1 Was-Related Disorders 24 WAS

Anatomical Context for Was-Related Disorders

MalaCards organs/tissues related to Was-Related Disorders:

39
Testes, Kidney, Heart

Publications for Was-Related Disorders

Articles related to Was-Related Disorders:

id Title Authors Year
1
WAS-Related Disorders ( 20301357 )
1993

Variations for Was-Related Disorders

Expression for Was-Related Disorders

Search GEO for disease gene expression data for Was-Related Disorders.

Pathways for Was-Related Disorders

GO Terms for Was-Related Disorders

Sources for Was-Related Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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