Was-related Disorders malady

MalaCards: Was-related Disorders is related to joubert syndrome and related disorders and joubert syndrome. An important gene associated with Was-related Disorders is AHI1 (Abelson helper integration site 1), and among its related pathways are Translation Insulin regulation of translation and Recycling of eIF2:GDP. The compounds testosterone and creatinine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and adipocyte, and related mouse phenotypes are embryogenesis and craniofacial.

GeneReviews summary for was

was-related disorders 15 16

Disease types for was-related disorders family:

tp63-related disorders	wt1-related disorders

Diseases related to was-related disorders by text searches and GeneDecks gene sharing:

(show top 50)    (show all 849)

id	Related Disease	Score	Top Affiliating Genes
1	joubert syndrome and related disorders	14.6	CEP290, MKKS, INVS, CC2D2A, TMEM67, TMEM237
2	joubert syndrome	14.6	CEP290, MKKS, INVS, CC2D2A, TMEM67, TMEM237
3	senior-loken syndrome	14.5	CEP290, INVS, CC2D2A, TMEM67, RPGRIP1L, AHI1
4	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	14.4	CEP290, CC2D2A, TMEM67, RPGRIP1L, AHI1, NPHP1
5	oculomotor apraxia	14.4	CEP290, CC2D2A, TMEM67, RPGRIP1L, AHI1, NPHP1
6	asphyxiating thoracic dystrophy	14.3	ATM, INVS, CC2D2A, TMEM67, RPGRIP1L, AHI1
7	fundus dystrophy	14.3	CEP290, MKKS, CC2D2A, TMEM67, RPGRIP1L, RHO
8	leukodystrophy	14.3	MPZ, FA2H, IDUA, PLP1, EIF2B2, EIF2B3
9	meckel syndrome	14.3	CEP290, MKKS, CC2D2A, TMEM67, RPGRIP1L
10	ovarioleukodystrophy	14.3	EIF2B2, EIF2B3, EIF2B1, EIF2B4, EIF2B5
11	leukoencephalopathy with vanishing white matter	14.3	EIF2B2, EIF2B3, EIF2B1, EIF2B4, EIF2B5
12	nephronophthisis	14.2	CEP290, INVS, CC2D2A, TMEM67, RPGRIP1L, WT1
13	muscle disorders	14.2	CHKB, MAPT, COL6A3, COL6A1, COL6A2
14	alcoholic pancreatitis	14.2	CFTR, ALDH2, AKR1A1, CYP2E1, ADH1B
15	coloboma	14.2	PAX6, CEP290, CC2D2A, TMEM67, RPGRIP1L, TCOF1
16	collagen type vi-related disorders	14.2	COL6A3, COL6A1, COL6A2
17	scleroatonic muscular dystrophy	14.2	COL6A3, COL6A1, COL6A2
18	coach syndrome	14.2	CC2D2A, TMEM67, RPGRIP1L
19	hypotonia	14.2	PAX6, CEP290, MPZ, FLNA, MECP2, MED12
20	infantile epileptic encephalopathy	14.1	CDKL5, FLNA, ARX, MECP2, CRH
21	west syndrome	14.1	CDKL5, FLNA, ARX, MECP2, IDUA, TLE1
22	optic atrophy	14.1	ARX, IGF1, PLP1, EIF2B2, EIF2B3, EIF2B1
23	encephalocele	14.1	CEP290, CC2D2A, TMEM67, RPGRIP1L
24	polydactyly	14.1	SALL1, CEP290, MKKS, FLNA, FLNC, FLNB
25	hereditary neuropathies	14.1	RAG1, MPZ, PLP1, PRX, PMP22
26	encephaloceles	14.1	CEP290, CC2D2A, TMEM67, RPGRIP1L
27	adrenocortical carcinoma	14.0	CHGA, CDKN1C, CYP11B2, CYP11B1, CYP21A2, NR4A2
28	cystic kidney	14.0	REN, KIF3A, CEP290, INVS, CC2D2A, TMEM67
29	apraxia	14.0	CEP290, ATM, MECP2, GRN, MAPT, CC2D2A
30	intestinal pseudo-obstruction	14.0	B2M, CFTR, FLNA, GNRH1, ACHE, POLG
31	corpus callosum	14.0	BDNF, SALL1, ARX, APOE, MAP2K2, SNCA
32	bethlem myopathy	13.9	DMD, COL6A3, COL6A1, COL6A2
33	neurilemmoma	13.9	MPZ, SNCA, ACHE, DES, DCX, PMP22
34	gardner syndrome	13.9	KIF3A, MAPRE1, CTNNB1
35	cocaine abuse	13.9	BDNF, CHKB, DRD2, NR4A2, SNCA, PLP1
36	essential tremor	13.9	FMR1, APOB, CYP2C19, SNCA, RPGRIP1L, ADH1B
37	drug dependence	13.9	CNR1, BDNF, CHRM2, DRD2, SNCA, CRH
38	connective tissue disease	13.9	FBN1, FBN2, COL1A1, COL5A1, ELN, TGFBR2
39	glucocorticoid-remediable aldosteronism	13.9	REN, CYP11B2, CYP11B1, ADD1
40	ullrich congenital muscular dystrophy	13.9	CHKB, AQP4, DMD, COL6A3, COL6A1, COL6A2
41	pulmonary valve stenosis	13.9	MAP2K2, PTPN11, ELN, SOS1
42	craniofacial abnormalities	13.9	FLNB, IDUA, TGFBR1, TGFBR2, RUNX2
43	cerebrotendinous xanthomatosis	13.9	FLNC, APOA1, APOB, CALCA, NR1H4
44	movement disease	13.9	PARK7, FMR1, MAPT, DRD2, SNCA
45	substance dependence	13.9	CNR1, BDNF, DTNBP1, DRD2, CRH, PENK
46	periventricular nodular heterotopia	13.9	RELN, FLNA, FLNB, ELN, DCX
47	anthrax disease	13.8	BRAF, MKKS, MAP2K2, MAP2K1, ADCY10
48	albinism	13.8	RAB27A, PAX6, AP3B1, GNAI1, HPS1, DTNBP1
49	alcoholism	13.8	CNR1, CHRM2, CFTR, MAPT, HTR2A, ALDH2
50	cardiofaciocutaneous syndrome	13.8	BRAF, MAP2K2, MAP2K1, HRAS, PTPN11, SOS1

Approved drugs:

Drug clinical trials:

Genetic tests related to was-related disorders:

id	Genetic test	Affiliating Genes
1	Was-related Disorders clinical/research	WAS

MalaCards organs/tissues related to was-related disorders:

²²

MGI Mouse Phenotypes related to was-related disorders:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryogenesis phenotype	MP:0005380	INF	PIGA, KIF3A, BRAF, RAF1, PAX6, SALL4
2	craniofacial phenotype	MP:0005382	INF	PIGA, KIF3A, RAG2, PAX6, BDNF, SALL4
3	cardiovascular system phenotype	MP:0005385	INF	KL, REN, KIF3A, BRAF, LPL, VDR
4	hematopoietic system phenotype	MP:0005397	INF	PIGA, BRAF, RAG2, RAG1, RAB27A, ATM
5	endocrine/exocrine gland phenotype	MP:0005379	INF	KL, XDH, AVPR1B, , CDKN1C, FMR1
6	liver/biliary system phenotype	MP:0005370	INF	LPL, RAG2, RAG1, CHRM2, CFTR,
7	limbs/digits/tail phenotype	MP:0005371	INF	KL, KIF3A, VDR, LEP, CHKB, SALL1
8	renal/urinary system phenotype	MP:0005367	INF	KL, REN, KIF3A, BRAF, RAG1, PAX6
9	immune system phenotype	MP:0005387	INF	KL, REN, BRAF, VDR, RAF1, PAX6
10	digestive/alimentary phenotype	MP:0005381	INF	PIGA, KL, RELN, KIF3A, BRAF, VDR
11	cellular phenotype	MP:0005384	INF	PIGA, KL, RELN, CNR1, KIF3A, BRAF
12	pigmentation phenotype	MP:0001186	10.0	BRAF, RAG1, RAB27A, PAX6, CEP290, GRN
13	taste/olfaction phenotype	MP:0005394	9.9	CNR1, PAX6, BDNF, MKKS, MAPT, GNAT3
14	mortality/aging	MP:0010768	INF	PIGA, KL, RELN, REN, CNR1, KIF3A
15	hearing/vestibular/ear phenotype	MP:0005377	INF	VDR, RAG1, PAX6, BDNF, SALL1, SALL4
16	integument phenotype	MP:0010771	INF	PIGA, KL, RELN, CNR1, BRAF, RAG2
17	muscle phenotype	MP:0005369	INF	KL, RELN, REN, BRAF, LPL, VCP
18	reproductive system phenotype	MP:0005389	INF	PIGA, REN, VDR, RAG2, LIPC, PAX6
19	growth/size phenotype	MP:0005378	INF	PIGA, KL, RELN, REN, CNR1, KIF3A
20	respiratory system phenotype	MP:0005388	INF	KL, KIF3A, LPL, RAG2, RAG1, PAX6
21	homeostasis/metabolism phenotype	MP:0005376	INF	KL, REN, CNR1, KIF3A, BRAF, LPL
22	vision/eye phenotype	MP:0005391	INF	RELN, KIF3A, BRAF, RAG1, RAF1, RAB27A
23	nervous system phenotype	MP:0003631	INF	PIGA, KL, RELN, REN, CNR1, BRAF
24	adipose tissue phenotype	MP:0005375	INF	KL, CNR1, BRAF, LPL, LEP, XDH
25	normal phenotype	MP:0002873	INF	REN, BRAF, RAG2, RAG1, PAX6, BDNF
26	no phenotypic analysis	MP:0003012	INF	CNR1, CLEC4A, BDNF, ATM, INS, MECP2
27	behavior/neurological phenotype	MP:0005386	INF	PIGA, KL, RELN, REN, CNR1, KIF3A
28	tumorigenesis	MP:0002006	INF	PIGA, BRAF, RAG2, RAG1, PAX6, LEP
29	skeleton phenotype	MP:0005390	INF	PIGA, CNR1, KIF3A, BRAF, VDR, VCP
30	other phenotype	MP:0005395	INF	KL, CNR1, FBN1, APOE, APP, MAPT

Articles related to was-related disorders:

(show top 50)    (show all 167)

id	Title	Authors	Year	Affiliating Genes
1	TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. (22152675)	Huang L.... Boycott K.M.	2011	MKKS, TMEM237
2	Molecular genetic analysis of the PLP1 gene in 38 fam ilies with PLP1-related disorders: identification and functional characterizati on of 11 novel PLP1 mutations. (21679407)	Grossi S.... Filocamo M.	2011	PLP1
3	A nonsense mutation of IDH1 in myelodysplastic syndro mes and related disorders. (20962861)	Yoshida K.... Ogawa S.	2010	IDH1, IDH2
4	Bile acid-activated receptors in the treatment of dys lipidemia and related disorders. (19932133)	Fiorucci S.... Mencarelli A.	2010	VDR, NR1H4, NR1I2
5	DJ-1 and prevention of oxidative stress in Parkinson' s disease and other age-related disorders. (19686841)	Kahle P.J.... Gasser T.	2009	PARK7
6	Improved methodology for assessment of mRNA levels in blood of patients with FMR1 related disorders. (19505339)	Godler D.E.... Choo K.H.	2009	FMR1
7	MKS3/TMEM67 mutations are a major cause of COACH Syndrome, a Joubert Syndrome related disorder with liver involvement. (19058225)	Brancati F.... Valente E.M.	2009	TMEM67
8	Gardner's syndrome (familial adenomatous polyposis): a cilia-related disorder. (19573802)	GA^mez GarcA-a E.B.... Knoers N.V.	2009	CTNNB1, MAPRE1, KIF3A
9	Natural history of adult-onset eIF2B-related disorder s: a multi-centric survey of 16 cases. (19625339)	Labauge P.... Boespflug-Tanguy O.	2009	EIF2B2, EIF2B5
10	Clinical and molecular features of Joubert syndrome a nd related disorders. (19876931)	Parisi M.A.	2009	TMEM67
11	Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disorders. (20016818)	Horzinski L.... Fogli A.	2009	EIF2B4, EIF2B5
12	Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders. (19220298)	Nakahashi H.... Karasawa M.	2009	IGHV1-69
13	Clinical and genetic findings of five patients with W T1-related disorders. (19169475)	Andrade J.G.... Maciel-Guerra A.T.	2008	WT1
14	Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders. (19075704)	Ono K.... Yamada M.	2008	SNCA
15	Clinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders. (19092437)	Moskowitz S.M.... Cutting G.R.	2008	CFTR
16	Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders. (19001166)	Webb A.... Wilhelmsen K.C.	2008	MAPT
17	Multiplex ligation-dependent probe amplification (MLPA) enhances the molecular diagnosis of aniridia and related disorders. (18483559)	Redeker E.J.... Mannens M.M.	2008	PAX6
18	Elevated ghrelin level in women of normal weight with amenorrhea is related to disordered eating. (18001718)	Schneider L.F.... Warren M.P.	2008	GHRL
19	Lack of NPHP2 mutations in a newborn infant with Joubert syndrome-related disorder presenting as end-stage renal disease. (17216245)	Assadi F.	2007	INVS
20	Joubert syndrome (and related disorders) (OMIM 213300). (17377524)	Parisi M.A.... Glass I.A.	2007	NPHP1, AHI1
21	Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. (17445278)	Zinkstok J.R.... Linszen D.H.	2007	DTNBP1
22	Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. (17217930)	Gratacos M.... Estivill X.	2007	BDNF
23	The importance of mutation detection in Marfan syndrome and Marfan-related disorders: report of 193 FBN1 mutations. (17657824)	Comeglio P.... Child A.	2007	FBN1
24	Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. (17982586)	Porjesz B.... Rangaswamy M.	2007	CHRM2
25	Costello syndrome and related disorders. (18025929)	Quezada E.... Gripp K.W.	2007	HRAS, MAP2K2
26	Contribution of genetic factors to the pathogenesis of Paget's disease of bone and related disorders. (17229006)	Lucas G.J.... Ralston S.H.	2006	VCP, TNFRSF11A
27	Recent studies of lipoprotein kinetics in the metabolic syndrome and related disorders. (16407713)	Chan D.C.... Watts G.F.	2006	APOA1, APOB, CETP
28	Noonan syndrome and related disorders: alterations in growth and puberty. (17177115)	Noonan J.A.	2006	PTPN11
29	Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. (16987887)	Gelb B.D.... Tartaglia M.	2006	HRAS, PTPN11
30	A new osteochondrodysplasia with severe osteopenia, preaxial polydactyly, clefting and dysmorphic features resembling filamin-related disorders. (17009344)	Colombani M.... Faivre L.	2006	FLNA, FLNB, FLNC
31	Resting metabolic rate is an important predictor of serum adiponectin concentrations: potential implications for obesity-related disorders. (16002795)	Ruige J.B.... Van Gaal L.F.	2005	ADIPOQ, INS
32	Are vasoactive neuropeptide autoimmune fatigue-related disorders mediated via G protein-coupled receptors? (15893112)	Staines D.	2005	CALCA, GNAI1, ADCY10
33	Genetic basis of Joubert syndrome and related disorders of cerebellar development. (16244321)	Louie C.M.... Gleeson J.G.	2005	NPHP1, AHI1
34	Aldosterone synthase deficiency and related disorders. (15134805)	White P.C.	2004	CYP11B2, CYP21A2
35	Ultrastructural analysis of granulocyte inclusions in genetically confirmed MYH9-related disorders. (15020273)	Pujol-Moix N.... Espanol I.	2004	MYH9
36	Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders. (12791038)	Park J.-H.... Park J.-G.	2003	MEN1
37	Circulating angiogenic cytokines in multiple myeloma and related disorders. (12799213)	Urba ska-Rys H.... Robak T.	2003	IL6, B2M
38	TCOF1 mutations excluded from a role in other first and second branchial arch-related disorders. (12210332)	Splendore A.... Wulfsberg E.A.	2002	TCOF1
39	Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease. (11171287)	Masana L.... Galton D.J.	2001	LPL, APOE, APOA1
40	Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans. (11726538)	Moghadasian M.H.... Frohlich J.J.	2001	APOE
41	SALL1 mutations in Townes-Brocks syndrome and related disorders. (11102974)	Kohlhase J.	2000	SALL1
42	Williams syndrome and related disorders. (11701637)	Morris C.A.... Mervis C.B.	2000	ELN
43	Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders. (11185990)	Yoon S.Y.... Tefferi A.	2000	TGFB1
44	Lansoprazole. An update of its pharmacological properties and clinical efficacy in the management of acid-related disorders. (9279507)	Langtry H.D.... Wilde M.I.	1997	HRH2
45	The differential diagnosis of the human dystrophinopathies and related disorders. (8894415)	Kakulas B.A.	1996	DMD
46	Inherited neuropathies: Charcot-Marie-Tooth disease and related disorders. (7952853)	Chance P.F.... Lupski J.R.	1994	PMP22, MPZ
47	Identification of defects in the fibrillin gene and protein in individuals with the Marfan syndrome and related disorders. (8180508)	Milewicz D.M.	1994	FBN1
48	Free and decomplexed human immunodeficiency virus p24 antigenaemia in black patients with AIDS and AIDS-related disorders. (8258048)	BAclec L.... Payan C.	1993	CD9
49	Acrivastine. A review of its pharmacological properti es and therapeutic efficacy in allergic rhinitis, urticaria and related disorde rs. (1715267)	Brogden R.N.... McTavish D.	1991	HRH1
50	Clinical evaluation of cefuzonam of severe infections in leukemia and related disorders (2283706)	Tsuda S.... Fujii H.	1990	CSF3

Genes related to was-related disorders according to GeneCards:

(show top 50)    (show all 171)

id	Symbol	Description	Score	GeneCards Section Context
1	AHI1	Abelson helper integration site 1	11.0	Publications, Summaries
2	TMEM237	transmembrane protein 237	11.0	Publications
3	TMEM67	transmembrane protein 67	11.0	Publications
4	COL6A2	collagen, type VI, alpha 2	11.0	Publications
5	NPHP1	nephronophthisis 1 (juvenile)	11.0	Publications
6	SALL4	sal-like 4 (Drosophila)	11.0	Publications
7	MKKS	McKusick-Kaufman syndrome	11.0	Publications
8	COL6A1	collagen, type VI, alpha 1	11.0	Publications
9	DCX	doublecortin	11.0
10	CC2D2A	coiled-coil and C2 domain containing 2A	11.0
11	RPGRIP1L	RPGRIP1-like	11.0	Publications
12	CEP290	centrosomal protein 290kDa	11.0	Publications
13	COL6A3	collagen, type VI, alpha 3	11.0
14	FMR1	fragile X mental retardation 1	11.0	Publications
15	POLG	polymerase (DNA directed), gamma	11.0	Publications
16	PLP1	proteolipid protein 1	11.0	Publications
17	INVS	inversin	11.0	Publications
18	MAPT	microtubule-associated protein tau	11.0	Publications
19	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
20	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
21	FLNB	filamin B, beta	11.0	Publications
22	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0	Publications
23	SLC29A3	solute carrier family 29 (nucleoside transporters), member 3	11.0	Summaries
24	IGHV1-69	immunoglobulin heavy variable 1-69	11.0	Publications
25	CYP2A	cytochrome P450, family 2, subfamily A	11.0	Publications
26	EIF2B1	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	11.0	Publications
27	EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	11.0	Publications
28	EIF2B5	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	11.0	Publications
29	PRX	periaxin	11.0	Publications
30	EIF2B4	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	11.0	Publications
31	AVPR1B	arginine vasopressin receptor 1B	11.0	Publications
32	ARX	aristaless related homeobox	11.0	Publications
33	TLR8	toll-like receptor 8	11.0	Publications
34	SALL1	sal-like 1 (Drosophila)	11.0	Publications
35	NMUR1	neuromedin U receptor 1	11.0	Publications
36	CTNS	cystinosin, lysosomal cystine transporter	11.0	Publications
37	KIF3A	kinesin family member 3A	11.0	Publications
38	PENK	proenkephalin	11.0	Publications
39	HPS1	Hermansky-Pudlak syndrome 1	11.0	Publications
40	RAG2	recombination activating gene 2	11.0	Publications
41	HRH2	histamine receptor H2	11.0	Publications
42	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.0	Publications
43	EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	11.0	Publications
44	MEN1	multiple endocrine neoplasia I	11.0	Publications
45	FA2H	fatty acid 2-hydroxylase	11.0	Publications
46	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	11.0	Publications
47	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
48	FBN1	fibrillin 1	11.0	Publications
49	VCP	valosin containing protein	11.0	Publications
50	RAG1	recombination activating gene 1	11.0	Publications

Pathways related to was-related disorders according to GeneDecks:

(show top 50)    (show all 220)

id	Pathway	Score	Top Affiliating Genes
1	Translation Insulin regulation of translation10	11.0	EIF2B4, SOS1, EIF2B5, EIF2B3, EIF2B2, MAP2K2
2	Recycling of eIF2:GDP38	10.9	EIF2B4, EIF2B3, EIF2B2, EIF2B1, EIF2B5
3	Translation _Regulation of EIF2 activity41	10.7	HRAS, RAF1, MAP2K2, MAP2K1, EIF2B2, SOS1
4	Translation Regulation activity of EIF4F10	10.6	SOS1
5	Translation_Insulin regulation of translation41	10.4	EIF2B4, EIF2B3, MAP2K1, HRAS, SOS1, EIF2B5
6	Insulin Receptor Pathway36	10.4	MAP2K2, MAP2K1, HRAS, RAF1, BRAF
7	Translation Regulation activity of EIF210	10.3	SOS1, HRAS, MAP2K1, MAP2K2, RAF1, EGF
8	Development Ligand-independent activation of ESR1 and ESR210	10.3	MAP2K2, HRAS, HRH1, MAP2K1, HRH2, EGF
9	Translation _Regulation of EIF4F activity41	10.2	EGF, MAP2K1, SOS1, MAP2K2, HRAS
10	IGF1R Signaling36	10.1	BRAF, RAF1, MAP2K2, MAP2K1, IGF1, EIF2B5
11	Chronic myeloid leukemia20	9.9	MAP2K2, BRAF, RAF1, MAP2K1, ABL1, TGFB1
12	Adipocytokines & Insulin Signaling37	9.8	PTPN11, INS, BRAF, LEP, MAP2K2, SOS1
13	Development_Ligand-independent activation of ESR1 and ESR241	9.7	HRH2, MAP2K2, MAP2K1, IGF1, HRAS, HRH1
14	Statin Pathway, Pharmacodynamics34	9.6	APOB, ABCB1, LPL, LIPC, APOA1, APOC3
15	Signaling in Gap Junctions36	9.5	HTR2A, BRAF, RAF1, MAP2K2, SOS1, CTNNB1
16	CREB Pathway36	9.4	MAP2K2, IL2RA, BDNF, SOS1, TGFBR1, GNAI1
17	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.3	TNFSF11, IGF1, IL6, CALCA, TNFRSF11A, APOE
18	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.3	RUNX2, COL1A1, TNFSF11, CALCA, IGF1, APOE
19	MAPK signaling pathway20	9.2	SOS1, MAP2K2, TGFB1, EGF, HRAS, MAP2K1
20	Signaling Involved in Cardiac Hypertrophy36	9.1	HRAS, MAP2K2, TGFBR1, TGFB1, EIF2B5, TGFBR2
21	PPAR Pathway36	9.0	SOS1, RAF1, IL2RA, IL6, MAP2K1, IGF1
22	GSK3 Signaling36	9.0	BDNF, EIF2B2, CTNNB1, GH1, HRAS, GNRH1
23	Colorectal Cancer Metastasis36	8.8	CTNNB1, MAP2K1, MAP2K2, IL6, SOS1, TLR7
24	Transcription_Androgen Receptor nuclear signaling41	8.7	IL6, TGFBR2, EGF, SOS1, TGFBR1, RAF1
25	Transcription Androgen Receptor nuclear signaling10	8.7	RAF1, IL6, MAP2K1, CTNNB1, EGF, TGFB1
26	Prostate cancer20	8.7	BRAF, MAP2K1, CTNNB1, RAF1, INS, MAP2K2
27	Selected targets of GCR-alpha10	8.4	CYP2C19, LEP, INS, IL6, ELN, NR1I3
28	eIF2 Pathway36	8.4	GNRH1, IGF1, MAP2K1, MAP2K2, IL6, IL2RA
29	Nanog in Mammalian ESC Pluripotency36	8.1	RAF1, BDNF, IL6, MAP2K2, CTNNB1, BRAF
30	Pancreatic Adenocarcinoma36	8.1	MAP2K1, PENK, BRAF, GH1, SOS1, TGFBR1
31	Rac1 Pathway36	7.9	PENK, TGFBR1, TGFB1, EGF, GH1, HRAS
32	TGF-Beta Pathway36	7.9	IL8, PENK, SOS1, TGFBR2, TGFBR1, TGFB1
33	p70S6K Signaling36	7.8	MAP2K1, SOS1, PENK, TGFBR1, MAP2K2, IL6
34	MAPK Family Pathway36	7.7	TGFB1, PENK, GH1, BRAF, RAF1, BDNF
35	Antioxidant Action of Vitamin-C36	7.7	FLNB, TNFSF11, IL2RA, IL6, IL8, IGF1
36	cAMP Pathway36	7.5	CRP, EGF, TGFBR1, PENK, ADD1, ADD2
37	Axon guidance38	INF	RAF1, COL6A1, COL6A2, ABL1, COL5A1, COL6A3
38	Integrin Pathway36	INF	COL5A1, COL6A2, ELN, SOS1, RAF1, COL6A3
39	Rho Family GTPases36	INF	TNFSF11, COL5A2, COL6A3, COL5A1, COL6A1, MAP2K1
40	Inhibition of Angiogenesis by TSP136	INF	FBN1, TGFBR2, TGFBR1, ELN, COL6A2, FBN2
41	ERK Signaling36	INF	MAP2K1, MAP2K2, FBN2, FBN1, IL6, PAX6
42	FAK1 Signaling36	INF	MAP2K1, COL6A1, COL5A1, COL6A3, COL5A2,
43	Focal adhesion20	INF	COL6A1, RELN, RAF1, FLNA, COL6A2, FLNB
44	ILK Signaling36	INF	COL6A1, COL6A3, COL5A2, COL5A1, EGF, ELN
45	GnRH Signaling36	INF	GNRH1, COL5A1, MAP2K1, BRAF, RAF1, FBN1
46	Molecular Mechanisms of Cancer36	INF	PENK, SOS1, PSEN1, TGFBR2, TGFBR1, TGFB1
47	MAPK Signaling36	INF	TGFBR1, TGFB1, HRAS, GNRH1, GNAI1, IGF1
48	PTEN Pathway36	INF	COL6A2, EGF, ELN, COL6A1, COL5A1, FBN1
49	Phospholipase-C Pathway36	INF	COL5A2, IL2RA, RAF1, BDNF, IL6, FBN1
50	Selected targets of HNF110	INF	, NR1H4, NR1I2, CYP1A2, APOB, APOA1

Compounds related to was-related disorders according to GeneDecks:

(show top 50)    (show all 519)

id	Compound	Score	Top Affiliating Genes
1	testosterone32 9 18 9	INF	SERPINA7, LPL, VDR, RAF1, LIPC, PARK7
2	creatinine32	INF	REN, SERPINA7, VDR, BDNF, LEP, CHGA
3	cimetidine32 9 9	INF	XDH, CD9, HRH1, HRH2, AKR1A1,
4	lactate32	INF	LPL, BDNF, CHGA, CHKB, XDH, B2M
5	tyrosine32	INF	KL, RELN, SERPINA7, BRAF, VCP, RAF1
6	threonine32	10.3	SERPINA7, RAF1, CHRM2, MKKS, MAPT, MAP2K2
7	n acetylcysteine32	9.8	RAF1, BDNF, CFTR, ATM, IL2RA, APOE
8	fatty acid32	9.4	BRAF, LEP, MPZ, CD9, INS, FASN
9	pge232	9.3	REN, RAF1, CFTR, APOA1, MAP2K1, GNAI1
10	corticosterone32 18	10.2	CNR1, SERPINA7, BDNF, AVPR1B, MPO, APP
11	opiate32	9.1	CHRM2, APP, GNAI1, GNRH1, HRH1, HRH2
12	propranolol32 34 9 18 9	13.0	REN, CHGA, MPO, APP, HTR1D, CALCA
13	progesterone32 42 9 18 9	12.9	SERPINA7, BRAF, CHGA, B3GAT1, MPZ, FBN1
14	chloramphenicol32 9 9	10.8	SERPINA7, LPL, VDR, RAF1, CHGA, CETP
15	forskolin32 42 9 9	11.8	REN, BRAF, RAF1, BDNF, CHRM2, CHGA
16	5-hydroxytryptamine32	8.7	CNR1, RAF1, CHRM2, CHGA, CFTR, APP
17	glutamate32	8.6	CNR1, BRAF, VDR, LEP, CFTR, MPZ
18	intralipid32	8.6	LPL, LIPC, LEP, CETP, APOA1, APOB
19	aspirin32 34 18	10.5	CNR1, SERPINA7, VDR, RAF1, CHKB, CFTR
20	gnrh32	8.5	RAF1, LEP, CHRM2, CFTR, INS, MAP2K1
21	valine32	8.5	BRAF, LPL, RAF1, BDNF, B2M, CFTR
22	h2o232	8.2	PARK7, BDNF, LEP, XDH, CFTR, MPO
23	ly29400232	8.1	LEP, IL6, IL8, FASN, MAP2K1, GNAI1
24	epinephrine32 9 18 9	10.9	REN, BDNF, LEP, CHGA, CHKB, CFTR
25	alanine32	7.6	CNR1, SERPINA7, BRAF, VDR, RAG1, RAF1
26	losartan32 34 9 9	10.5	REN, LEP, XDH, ATM, APOE, IGF1
27	simvastatin32 34 42 9 18 9	12.5	LPL, CHKB, CETP, IL6, IL8, APOA1
28	thymidine32 18	8.2	VDR, RAF1, BDNF, CHKB, B2M, CD9
29	hydrocortisone32 9 9	9.1	REN, INS, IL6, IL8, IGF1, CALCA
30	glutamine32	6.8	LPL, VDR, VCP, RAF1, CHKB, B2M
31	thyroxine32 18	7.7	REN, SERPINA7, LPL, VDR, LIPC, LEP
32	vegf32	6.4	KL, REN, BRAF, RAF1, PAX6, BDNF
33	indomethacin32 9 9	8.3	REN, CNR1, LPL, RAF1, BDNF, LEP
34	cycloheximide32	5.1	LPL, VDR, RAF1, PARK7, BDNF, LEP
35	dmso32	INF	RAG2, CHGA, XDH, CFTR, APOB, MAP2K1
36	dopamine32 9 18 9	INF	REN, RAF1, PARK7, BDNF, CHKB, CFTR
37	calcium32 9 18 9	INF	KL, RELN, REN, CNR1, BRAF, VCP
38	adenylate32	INF	CNR1, LPL, VDR, BDNF, CHRM2, CHGA
39	arginine32	INF	REN, CNR1, SERPINA7, BRAF, VDR, LIPC
40	vitamin a32 9 18 9	INF	SERPINA7, LPL, VDR, RAF1, LIPC, LEP
41	nicotine32 34 9 9	INF	CYP1A2, CYP2C19, , CRH, GAST
42	cysteine32	INF	VDR, RAG1, RAF1, CLEC4A, PARK7, CHKB
43	glycerol32 9 18 9	INF	LPL, LIPC, LEP, CHKB, CFTR, INS
44	dhea32	INF	LEP, INS, IGF1, GH1, GHRL,
45	clozapine32 34 9 9	INF	LEP, CHRM2, CHKB, MPO, IL2RA, HTR1D
46	formaldehyde32 18	INF	CHGA, B2M, CFTR, MPO, IL2RA, APOA1
47	caffeine32 34 9 18 9	INF	LPL, VDR, RAG2, RAG1, CHGA, XDH
48	tamoxifen32 34 9 9	INF	SERPINA7, LPL, VDR, RAF1, BDNF, LEP
49	serine32	INF	RELN, CNR1, SERPINA7, BRAF, VDR, VCP
50	oligonucleotide32	INF	BRAF, RAF1, PARK7, CHGA, CD9, FMR1

Cellular components related to was-related disorders according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	MAP2K2, MAPRE1, MAP2K1, IDH1, , HRAS
2	dendrite	GO:030425	INF	RAB27A, RELN, CHRM2, APOE, ,
3	eukaryotic translation initiation factor 2B complex	GO:005851	10.9	EIF2B2, EIF2B3, EIF2B1, EIF2B4, EIF2B5
4	TCTN-B9D complex	GO:036038	10.8	AHI1, TMEM67, CC2D2A, CEP290
5	sarcolemma	GO:042383	10.3	DES, COL6A3, DMD, DTNBP1, FLNC, COL6A1
6	intermediate-density lipoprotein particle	GO:034363	10.2	APOE, APOB, APOC3
7	chylomicron	GO:042627	10.2	APOB, APOE, APOC3, LPL
8	cell cortex	GO:005938	10.2	FLNA, SNCA, FLNB, MAP2K2, MAP2K1, CTNNB1
9	very-low-density lipoprotein particle	GO:034361	10.1	LPL, APOA1, APOC3, APOE, APOB
10	extracellular space	GO:005615	5.1	LEP, B2M, CETP, MPO, INS, GRN
11	endoplasmic reticulum lumen	GO:005788	INF	COL5A2, , COL1A1, GHRL, APOB, APOA1
12	extracellular matrix	GO:031012	INF	PLAT, COL6A2, COL6A1, COL5A1, COL6A3, COL5A2
13	integral to plasma membrane	GO:005887	INF	KL, MPZ, TNFSF11, , CNR1, CLEC4A
14	cytoplasm	GO:005737	INF	INVS, MEN1, AQP4, APOB, APOE, APP
15	axon	GO:030424	INF	ADCY10, TAC1, TGFB1, SNCA, DRD2, DTNBP1
16	plasma membrane	GO:005886	INF	APP, APOE, APOB, APOA1, AQP4, FASN
17	extracellular region	GO:005576	INF	TGFB1, TAC1, PENK, ADIPOQ, GAST, AGER
18	centrosome	GO:005813	INF	RPGRIP1L, AHI1, PSEN1, WRN, CTNNB1, TMEM67
19	protein complex	GO:043234	INF	DMD, COL6A1, MYH9, PTPN11, GNAT3,

Biological processes related to was-related disorders according to GeneDecks:

(show top 50)    (show all 65)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-dependent	GO:045893	INF	CDKN1C, PAX6, RUNX2, CEP290, NR1I2,
2	negative regulation of cell proliferation	GO:008285	INF	PMP22, TGFB1, MEN1, IL6, IL8, MAP2K1
3	cilium assembly	GO:042384	11.2	CEP290, KIF3A, MKKS, FLNA, CC2D2A, TMEM67
4	cellular response to stimulus	GO:051716	11.1	EIF2B2, EIF2B1, EIF2B4, EIF2B5, EIF2B3
5	oligodendrocyte development	GO:014003	11.0	EIF2B1, EIF2B3, EIF2B4, EIF2B5, EIF2B2, CD9
6	negative regulation of translational initiation in response to stress	GO:032057	11.0	EIF2B5, EIF2B1, EIF2B3, EIF2B4
7	response to heat	GO:009408	10.8	EIF2B5, CALCA, EIF2B1, EIF2B2, EIF2B3, EIF2B4
8	protein heterotrimerization	GO:070208	10.8	ADIPOQ, COL6A2, COL6A1, COL1A1
9	response to peptide hormone stimulus	GO:043434	10.7	EIF2B5, EIF2B4, BRAF, GNAI1, PLAT, COL1A1
10	long-term memory	GO:007616	10.6	DRD2, MECP2, RELN, CRH, TAC1
11	pre-B cell allelic exclusion	GO:002331	10.6	ATM, RAG1, RAG2
12	response to glucose stimulus	GO:009749	10.6	EIF2B4, EIF2B1, EIF2B3, COL6A3, EIF2B2, EIF2B5
13	neurological system process involved in regulation of systemic arterial blood pressure	GO:001976	10.5	DRD2, MECP2, CALCA
14	negative regulation of blood pressure	GO:045776	10.5	ADIPOQ, DRD2, CALCA, MKKS, CNR1
15	activation of MAPKK activity	GO:000186	10.3	RAF1, PSEN1, MAP2K2
16	high-density lipoprotein particle remodeling	GO:034375	10.3	LIPC, APOC3, APOA1, CETP, APOE
17	very-low-density lipoprotein particle remodeling	GO:034372	10.3	LPL, LIPC, CETP, APOE
18	reverse cholesterol transport	GO:043691	10.3	LIPC, CETP, APOA1, APOC3, APOE
19	triglyceride homeostasis	GO:070328	10.3	APOC3, LIPC, APOA1, LPL, CETP
20	neuron migration	GO:001764	10.2	CTNNB1, DCX, RELN, CDKL5, PAX6, MAPT
21	lipoprotein metabolic process	GO:042157	10.2	APOA1, CETP, OLR1, APOE, APOC3, LPL
22	low-density lipoprotein particle remodeling	GO:034374	10.2	MPO, APOB, LIPC, CETP
23	synaptic transmission	GO:007268	10.2	BRAF, MPZ, HTR1D, HTR2A, TAC1, ACHE
24	triglyceride metabolic process	GO:006641	10.2	APOC3, APOE, PTPN11, CETP, LPL
25	aging	GO:007568	10.1	SERPINA7, CNR1, CALCA, WRN, TGFB1, HTR2A
26	dendrite development	GO:016358	10.0	APP, MECP2, RELN, GHRL, BDNF
27	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	HRAS, MAP2K2, BRAF, MAP2K1, KL, RAF1
28	MAPK cascade	GO:000165	9.9	RAF1, TGFB1, HRAS, MAP2K1, MAP2K2, MEN1
29	cholesterol homeostasis	GO:042632	9.9	LIPC, CETP, APOA1, APOE, APOC3, APOB
30	regulation of blood pressure	GO:008217	9.7	LEP, CHGA, CALCA, TAC1, REN, CYP11B1
31	cholesterol metabolic process	GO:008203	9.7	LEP, CETP, APOB, APOE, LIPC, APOA1
32	monocyte chemotaxis	GO:002548	9.6	TNFRSF11A, CALCA, TNFSF11, IL6
33	G-protein coupled receptor signaling pathway	GO:007186	9.4	APOC3, AVPR1B, INS, CHRM2, IL8, GAST
34	response to drug	GO:042493	9.3	CTNNB1, REN, ADD3, TGFBR2, TGFB1, ABCB1
35	positive regulation of MAP kinase activity	GO:043406	9.3	HTR2A, GH1, TNFSF11, EGF, TGFB1, PSEN1
36	platelet degranulation	GO:002576	9.1	CD9, FLNA, APOA1, APP, EGF, TGFB1
37	inflammatory response	GO:006954	9.1	CRP, PARK7, IL6, IL8, TLR8, TAC1
38	signal transduction	GO:007165	8.9	NR1H4, VDR, ATM, FLNB, GRN, IL8
39	blood coagulation	GO:007596	8.8	DTNBP1, ABL1, EGF, COL1A1, OLR1, PTPN11
40	anti-apoptosis	GO:006916	8.7	BRAF, BDNF, PRNP, PSEN1, SNCA, GHRL
41	platelet activation	GO:030168	8.6	SOS1, TGFB1, EGF, RAF1, COL1A1, GNAI1
42	response to hypoxia	GO:001666	8.4	MECP2, ATM, DRD2, CRP, RAF1, TGFB1
43	positive regulation of cell proliferation	GO:008284	7.7	IGF1, HRAS, CSF3, HTR2A, TGFBR1, TGFB1
44	axon guidance	GO:007411	INF	COL5A2, RELN, COL6A3, COL5A1, COL6A1, COL6A2
45	kidney development	GO:001822	INF	, TGFBR1, WT1, INVS, SALL1, REN
46	xenobiotic metabolic process	GO:006805	INF	CYP2C19, , ALDH2, CYP11B1, CYP21A2, NR1I2
47	cell cycle arrest	GO:007050	INF	IL8, MAP2K1, HRAS, MEN1, , CDKN1C
48	extracellular matrix organization	GO:030198	INF	ELN, APP, COL1A1, , COL5A2, COL6A3
49	negative regulation of neuron apoptotic process	GO:043524	INF	, PSEN1, MECP2, SNCA, HRAS, BDNF
50	cell death	GO:008219	INF	PLP1, POLG, TGFB1, OLR1, , HTR2A

Molecular functions related to was-related disorders according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	drug binding	GO:008144	10.1	CNR1, NR1I2, DRD2, HTR2A, CHRM2, TLR7
2	hormone activity	GO:005179	8.5	ADIPOQ, CRH, GH1, GNRH1, IGF1, INS
3	growth factor activity	GO:008083	7.5	EGF, GH1, TGFB1, IL6, GRN, LEP
4	platelet-derived growth factor binding	GO:048407	INF	COL1A1, , COL5A1, COL6A1
5	extracellular matrix structural constituent	GO:005201	INF	FBN1, ELN, COL6A2, COL5A2, COL5A1,
6	protein homodimerization activity	GO:042803	INF	, APOE, FLNA, AVPR1B, XDH, PARK7
7	electron carrier activity	GO:009055	INF	CYP1A2, ALDH2, CYP2C19, CYP21A2, XDH, CYP11B1
8	protein binding	GO:005515	INF	MAPRE1, NR1H4, NR1I2, NR4A2, SNCA, CRH
9	heme binding	GO:020037	INF	, MPO, FA2H, CYP11B2, CYP1A2, CYP21A2
10	enzyme binding	GO:019899	INF	APOB, MAPT, CYP1A2, CYP2C19, , CTNNB1