MCID: WTR002
MIFTS: 19

Water-Clear Cell Adenoma

Categories: Cancer diseases

Aliases & Classifications for Water-Clear Cell Adenoma

MalaCards integrated aliases for Water-Clear Cell Adenoma:

Name: Water-Clear Cell Adenoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5401
NCIt 47 C4155
SNOMED-CT 64 26638004
UMLS 69 C0334321

Summaries for Water-Clear Cell Adenoma

Disease Ontology : 12 An adenoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Water-Clear Cell Adenoma is related to clear cell adenoma and adenoma. An important gene associated with Water-Clear Cell Adenoma is PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C). Related phenotype is homeostasis/metabolism.

Related Diseases for Water-Clear Cell Adenoma

Diseases related to Water-Clear Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
id Related Disease Score Top Affiliating Genes
1 clear cell adenoma 10.3
2 adenoma 10.3
3 sarcomatoid mesothelioma 10.2 GATA3 PAX8
4 ossification of the posterior longitudinal ligament of spine 10.2 GATA3 PTH
5 perivascular epithelioid cell tumor 10.2 GATA3 PAX8
6 invasive malignant thymoma 10.1 PAX8 SYP
7 uterine benign neoplasm 10.1 PTH SYP
8 rectum lymphoma 10.1 PTH SYP
9 hyperparathyroidism 10.1
10 vestibular gland benign neoplasm 10.1 PTH SYP
11 parathyroid gland disease 10.0 GATA3 PTH
12 prostate small cell carcinoma 10.0 GATA3 SYP
13 atheroembolism of kidney 10.0 PTH TG
14 male reproductive organ benign neoplasm 10.0 PTH SYP
15 guillain-barre syndrome 10.0 PTH TG
16 brain angioma 10.0 PTH TG
17 nephrogenic systemic fibrosis 10.0 PAX8 TG
18 tibia absent polydactyly arachnoid cyst 10.0 PAX8 TG
19 panhypophysitis 10.0 PAX8 TG
20 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 9.9 PAX8 TG
21 cardiovascular organ benign neoplasm 9.9 PTH TG
22 mediastinitis 9.9
23 meningovascular neurosyphilis 9.8 PAX8 TG
24 bladder diffuse clear cell adenocarcinoma 9.8 PAX8 TG
25 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.8 PAX8 TG
26 congenital granular cell tumor 9.8 SYP TG
27 mature teratoma 9.8 SYP TG
28 trachea sarcoma 9.7 SYP TG
29 primary bacterial infectious disease 9.7 PAX8 TG
30 gastrointestinal system cancer 9.6 PAX8 TG
31 chorea, hereditary benign 9.6 PAX8 TG
32 frontotemporal dementia and/or amyotrophic lateral sclerosis 4 9.6 PAX8 TG
33 fibrolamellar carcinoma 9.6 PAX8 PTH TG
34 non-distal trisomy 10q 9.5 PAX8 TG
35 benign shuddering attacks 9.3 PAX8 SYP TG
36 otosclerosis 9.3 PAX8 TG
37 pulmonary neuroendocrine tumor 7.5 GATA3 PAX8 PPP1R3B PPP1R3C PTH SYP

Graphical network of the top 20 diseases related to Water-Clear Cell Adenoma:



Diseases related to Water-Clear Cell Adenoma

Symptoms & Phenotypes for Water-Clear Cell Adenoma

MGI Mouse Phenotypes related to Water-Clear Cell Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 PPP1R3B PPP1R3C PTH TG GATA3 PAX8

Drugs & Therapeutics for Water-Clear Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Water-Clear Cell Adenoma

Genetic Tests for Water-Clear Cell Adenoma

Anatomical Context for Water-Clear Cell Adenoma

Publications for Water-Clear Cell Adenoma

Articles related to Water-Clear Cell Adenoma:

id Title Authors Year
1
Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism. ( 28382826 )
2017
2
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland. ( 28832084 )
2017
3
Water-clear cell adenoma of parathyroid gland - A case report. ( 27772915 )
2016
4
Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case. ( 23539328 )
2013
5
Water-clear cell adenoma: A rare form of hyperparathyroidism. ( 23995477 )
2013
6
Water-clear cell adenoma of the parathyroid gland: a rare entity. ( 15471124 )
2004
7
Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. ( 7487410 )
1995

Variations for Water-Clear Cell Adenoma

Expression for Water-Clear Cell Adenoma

Search GEO for disease gene expression data for Water-Clear Cell Adenoma.

Pathways for Water-Clear Cell Adenoma

GO Terms for Water-Clear Cell Adenoma

Biological processes related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.48 GATA3 PAX8
2 regulation of catalytic activity GO:0050790 9.46 PPP1R3B PPP1R3C
3 positive regulation of signal transduction GO:0009967 9.43 GATA3 PTH
4 inner ear morphogenesis GO:0042472 9.4 GATA3 PAX8
5 glycogen metabolic process GO:0005977 9.37 PPP1R3B PPP1R3C
6 thyroid gland development GO:0030878 9.26 PAX8 TG
7 mesonephros development GO:0001823 9.16 GATA3 PAX8
8 ventricular septum development GO:0003281 9.02 GATA3
9 otic vesicle development GO:0071599 8.96 GATA3 PAX8
10 positive regulation of thyroid hormone generation GO:2000611 8.62 GATA3 PAX8

Molecular functions related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 PTH TG
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 GATA3 PAX8
3 protein phosphatase regulator activity GO:0019888 8.62 PPP1R3B PPP1R3C

Sources for Water-Clear Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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