MCID: WTR002
MIFTS: 21

Water-Clear Cell Adenoma

Categories: Cancer diseases

Aliases & Classifications for Water-Clear Cell Adenoma

MalaCards integrated aliases for Water-Clear Cell Adenoma:

Name: Water-Clear Cell Adenoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5401
NCIt 46 C4155
SNOMED-CT 64 26638004
UMLS 69 C0334321

Summaries for Water-Clear Cell Adenoma

Disease Ontology : 12 An adenoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Water-Clear Cell Adenoma is related to clear cell adenoma and adenoma. An important gene associated with Water-Clear Cell Adenoma is PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C). Related phenotype is homeostasis/metabolism.

Related Diseases for Water-Clear Cell Adenoma

Diseases related to Water-Clear Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 clear cell adenoma 30.4 PTH TG
2 adenoma 10.4
3 barre-lieou syndrome 10.2 PPP1R3B PPP1R3C
4 hyperparathyroidism 10.2
5 parathyroid transitional clear cell adenoma 10.2
6 sarcomatoid renal cell carcinoma 10.1 GATA3 PAX8
7 primary hyperparathyroidism 10.1
8 ovarian brenner tumor 10.1 GATA3 PAX8
9 immune system organ benign neoplasm 10.1 PTH SYP
10 mixed type thymoma 10.1 PAX8 SYP
11 thymus lipoma 10.1 PTH SYP
12 organ system benign neoplasm 10.0 PTH SYP
13 malignant epithelial mesothelioma 10.0 PAX8 SYP
14 hypoparathyroidism 10.0 GATA3 PTH
15 cell type benign neoplasm 10.0 PTH SYP
16 cystitis cystica 10.0 GATA3 SYP
17 postsurgical hypothyroidism 10.0 PTH TG
18 thyroid crisis 10.0 PTH TG
19 mediastinitis 9.9
20 neonatal hypothyroidism 9.9 PAX8 TG
21 thyroid cancer, anaplastic 9.9 PAX8 TG
22 athyreosis 9.9 PAX8 TG
23 hypothyroidism, congenital, nongoitrous, 2 9.9 PAX8 TG
24 endocrine organ benign neoplasm 9.9 PTH TG
25 multinodular goiter 9.8 PAX8 TG
26 follicular adenoma 9.8 PAX8 TG
27 pendred syndrome 9.8 PAX8 TG
28 atypical follicular adenoma 9.8 SYP TG
29 malignant teratoma 9.8 SYP TG
30 congenital hypothyroidism 9.8 PAX8 TG
31 spermatocele 9.8 SYP TG
32 multiple endocrine neoplasia, type i 9.7 PTH SYP
33 papillary carcinoma 9.7 PAX8 TG
34 differentiated thyroid carcinoma 9.7 PAX8 TG
35 goiter 9.6 PAX8 TG
36 thyroid gland disease 9.6 PAX8 PTH TG
37 endocrine gland cancer 9.5 PAX8 SYP TG
38 thyroid cancer, nonmedullary, 2 9.4 PAX8 TG

Graphical network of the top 20 diseases related to Water-Clear Cell Adenoma:



Diseases related to Water-Clear Cell Adenoma

Symptoms & Phenotypes for Water-Clear Cell Adenoma

MGI Mouse Phenotypes related to Water-Clear Cell Adenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 GATA3 PAX8 PPP1R3B PPP1R3C PTH TG

Drugs & Therapeutics for Water-Clear Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Water-Clear Cell Adenoma

Genetic Tests for Water-Clear Cell Adenoma

Anatomical Context for Water-Clear Cell Adenoma

Publications for Water-Clear Cell Adenoma

Articles related to Water-Clear Cell Adenoma:

# Title Authors Year
1
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland. ( 28832084 )
2017
2
Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism. ( 28382826 )
2017
3
Water-clear cell adenoma of parathyroid gland - A case report. ( 27772915 )
2016
4
Water-clear cell adenoma: A rare form of hyperparathyroidism. ( 23995477 )
2013
5
Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case. ( 23539328 )
2013
6
Water-clear cell adenoma of the parathyroid gland: a rare entity. ( 15471124 )
2004
7
Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. ( 7487410 )
1995

Variations for Water-Clear Cell Adenoma

Expression for Water-Clear Cell Adenoma

Search GEO for disease gene expression data for Water-Clear Cell Adenoma.

Pathways for Water-Clear Cell Adenoma

GO Terms for Water-Clear Cell Adenoma

Biological processes related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of catalytic activity GO:0050790 9.49 PPP1R3B PPP1R3C
2 kidney development GO:0001822 9.48 GATA3 PAX8
3 positive regulation of signal transduction GO:0009967 9.46 GATA3 PTH
4 inner ear morphogenesis GO:0042472 9.43 GATA3 PAX8
5 regulation of phosphoprotein phosphatase activity GO:0043666 9.4 PPP1R3B PPP1R3C
6 glycogen metabolic process GO:0005977 9.37 PPP1R3B PPP1R3C
7 ventricular septum development GO:0003281 9.32 GATA3 PAX8
8 thyroid gland development GO:0030878 9.26 PAX8 TG
9 mesonephros development GO:0001823 9.16 GATA3 PAX8
10 otic vesicle development GO:0071599 8.96 GATA3 PAX8
11 positive regulation of thyroid hormone generation GO:2000611 8.62 GATA3 PAX8

Molecular functions related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 PTH TG
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 GATA3 PAX8
3 protein phosphatase regulator activity GO:0019888 8.62 PPP1R3B PPP1R3C

Sources for Water-Clear Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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