MCID: WTR001
MIFTS: 42

Waterhouse-Friderichsen Syndrome malady

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

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Sources:
65UMLS, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Waterhouse-Friderichsen Syndrome:

Name: Waterhouse-Friderichsen Syndrome 10 45 12 51 36 65
Fatal Pneumococcal Waterhouse-Friderichsen Syndrome 45 65
Waterhouse-Friderichsen Syndrome, Meningococcal 65
 
Meningococcal Hemorrhagic Adrenalitis 10
Wolfram Syndrome 65
Wfs 10

Classifications:



External Ids:

Disease Ontology10 DOID:9931
MeSH36 D014884
NCIt42 C85225
Orphanet51 100067
ICD10 via Orphanet28 A39.1+, E35.1*
MESH via Orphanet37 D014884
UMLS via Orphanet66 C0043068
ICD1027 A39.1
UMLS65 C0043068, C1403891, C2931288

Summaries for Waterhouse-Friderichsen Syndrome

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NIH Rare Diseases:45 Waterhouse–friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. it is usually caused by severe meningococcal infection or other severe, bacterial infection. symptoms include acute adrenal gland insufficiency, and profound shock. most patients with this condition are children, although adults may rarely be affected. it is deadly if not treated immediately. last updated: 2/4/2016

MalaCards based summary: Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to wolfram syndrome and acute adrenal insufficiency, and has symptoms including presyncope, syncope and dizziness. An important gene associated with Waterhouse-Friderichsen Syndrome is WFS1 (Wolframin ER Transmembrane Glycoprotein). Affiliated tissues include adrenal gland, t cells and pituitary, and related mouse phenotypes are growth/size/body region and mortality/aging.

Disease Ontology:10 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia:68 Waterhouse–Friderichsen syndrome (WFS), hemorrhagic adrenalitis or fulminant meningococcemia is... more...

Related Diseases for Waterhouse-Friderichsen Syndrome

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Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to waterhouse-friderichsen syndrome

Symptoms for Waterhouse-Friderichsen Syndrome

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UMLS symptoms related to Waterhouse-Friderichsen Syndrome:


presyncope, syncope, dizziness, tremor, seizures, ataxia

Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Waterhouse-Friderichsen Syndrome


Cochrane evidence based reviews: waterhouse-friderichsen syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

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Anatomical Context for Waterhouse-Friderichsen Syndrome

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MalaCards organs/tissues related to Waterhouse-Friderichsen Syndrome:

33
Adrenal gland, T cells, Pituitary, B cells, Lung, Prostate, Kidney

Animal Models for Waterhouse-Friderichsen Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Waterhouse-Friderichsen Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.1ARHGEF12, BARD1, CISD2, F2, PPT1, RFX6
2MP:00107685.9ARHGEF12, BARD1, CISD2, CLN3, CXCL12, F2

Publications for Waterhouse-Friderichsen Syndrome

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Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
A Case of Waterhouse-Friderichsen Syndrome Resulting from an Invasive Pneumococcal Infection in a Patient with a Hypoplastic Spleen. (26942021)
2016
2
Fatal Waterhouse-Friderichsen syndrome due to serotype C Neisseria meningitidis in a young HIV negative MSM (men who have sex with men). (25267809)
2014
3
Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. (23814386)
2013
4
Waterhouse Friderichsen Syndrome Complicating Fulminant Enterobacter Cloacae Sepsis in a Preterm Infant: The Unresolved Issue of Corticosteroids. (24328998)
2013
5
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. (21772601)
2011
6
Fatal pneumococcal Waterhouse-Friderichsen syndrome in a vaccinated adult with congenital asplenia. (19751638)
2009
7
Medical image. Meningococcal septic shock with adrenal apoplexy--Waterhouse-Friderichsen syndrome. (16868589)
2006
8
Postmortem measurement of serum procalcitonin concentration in Waterhouse-Friderichsen syndrome. (12587602)
2002
9
Spontaneous Waterhouse-Friderichsen syndrome in a gang-housed baboon. (11515675)
2001
10
Waterhouse-Friderichsen syndrome after infection with group A streptococcus. (11702906)
2001
11
Reminder--necrotizing fasciitis complicated by Waterhouse-Friderichsen syndrome. (10454031)
1999
12
Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. (7560209)
1995
13
Waterhouse-Friderichsen syndrome resulting from colchicine overdose. (8258815)
1993
14
Group A beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome. (1528655)
1992
15
Waterhouse-Friderichsen syndrome without purpura due to Haemophilus influenzae group B. (3873065)
1985
16
Adrenal, cutaneous and myocardial lesions in fulminating endotoxinemia (Waterhouse-Friderichsen syndrome). (7134067)
1982
17
Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. (7229096)
1981
18
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an adult. (6977494)
1981
19
Chest infection associated with the Waterhouse-Friderichsen syndrome. (6790062)
1981
20
Fatal cholera-like diarrhea with Waterhouse-Friderichsen syndrome, sickle-cell trait, and hyposplenism. (335288)
1977
21
Adrenal lesions in calves dying from endotoxin shock, with special reference to the Waterhouse-Friderichsen syndrome. (858809)
1977
22
Waterhouse Friderichsen syndrome. (1207489)
1975
23
Waterhouse Friderichsen syndrome. Endotoxin shock treated with massive doses of cortisol. (4705280)
1973
24
The Waterhouse-Friderichsen syndrome and its orthopaedic consequences. (5081691)
1972
25
Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. (5118056)
1971
26
Waterhouse-Friderichsen syndrome induced by pneumococcemic shock. (5467531)
1970
27
The pathology of the Waterhouse-Friderichsen syndrome. (5504755)
1970
28
Fatal meningitis due to Moraxella duplex: report of a case with Waterhouse-Friderichsen syndrome. (5655280)
1968
29
Fulminating meningococcemia (Waterhouse-Friderichsen syndrome): report of two patients successfully treated with chemotherapy, vasopressors, and adrenal steroids. (13664537)
1959
30
WATERHOUSE-Friderichsen syndrome. (13856902)
1959
31
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. (13512121)
1958
32
THE WATERHOUSE-FRIDERICHSEN syndrome failure of hydrocortisone therapy. (13398680)
1957
33
The early diagnosis of the Waterhouse-Friderichsen syndrome. (13435437)
1957
34
Recovery from Waterhouse-Friderichsen syndrome associated with use of norepinephrine to combat shock. (13385639)
1957
35
Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome. (13322226)
1956
36
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
37
Waterhouse-Friderichsen syndrome (W.-F.S.) (14375664)
1955
38
Waterhouse-Friderichsen syndrome: report of a case with recovery. (14350471)
1955
39
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
40
Mima polymorpha as a causative agent in Waterhouse-Friderichsen syndrome. (13157230)
1954
41
The Waterhouse-Friderichsen syndrome. (13050387)
1953
42
Norepinephrine in the treatment of the Waterhouse-Friderichsen syndrome; report of a case. (13098452)
1953
43
A fatal case of Still's disease associated with Waterhouse-Friderichsen syndrome due to pneumococcal septicaemia. (13036557)
1953
44
The prolonged Waterhouse-Friderichsen syndrome with renal and myocardial insufficiency. (13031407)
1953
45
Waterhouse-Friderichsen syndrome; report of a case with recovery. (14947936)
1952
46
Waterhouse-Friderichsen syndrome associated with septic abortion and sickle cell disease. (13002737)
1952
47
A case of Waterhouse-Friderichsen syndrome with recovery following the use of cortisone, aqueous adrenal cortical extract and chemotherapy. (14918718)
1952
48
The Waterhouse-Friderichsen syndrome in the differential diagnosis of acute abdominal crises. (14782113)
1950
49
Massive gastro-intestinal hemorrhage in fulminating meningococcus meningitis (Waterhouse-Friderichsen syndrome) with recovery. (20246682)
1947
50
The Waterhouse-Friderichsen Syndrome: Report of Three Cases in Adults with Necropsy Findings. (21434244)
1945

Variations for Waterhouse-Friderichsen Syndrome

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Expression for genes affiliated with Waterhouse-Friderichsen Syndrome

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Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for genes affiliated with Waterhouse-Friderichsen Syndrome

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GO Terms for genes affiliated with Waterhouse-Friderichsen Syndrome

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Biological processes related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumen acidificationGO:000704210.2CLN3, PPT1
2double-strand break repairGO:000630210.0BARD1, WHSC1
3protein catabolic processGO:00301639.9CLN3, PPT1
4adult locomotory behaviorGO:00083449.7CXCL12, PPT1
5double-strand break repair via nonhomologous end joiningGO:00063039.7BARD1, WHSC1

Sources for Waterhouse-Friderichsen Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet