WFS
MCID: WTR001
MIFTS: 38

Waterhouse-Friderichsen Syndrome (WFS) malady

Rare diseases, Infectious diseases, Endocrine diseases categories

Summaries for Waterhouse-Friderichsen Syndrome

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NIH Rare Diseases:44 Waterhouse–friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. it is caused by severe meningococcal infection or other severe, bacterial infection. symptoms include acute adrenal gland insufficiency, and profound shock. most patients with this condition are children, although adults may rarely be affected. it is deadly if not treated immediately. last updated: 1/8/2010

MalaCards: Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to wolfram syndrome and meningitis. An important gene associated with Waterhouse-Friderichsen Syndrome is CISD2 (CDGSH iron sulfur domain 2), and among its related pathways is Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. Affiliated tissues include adrenal gland, skin and spleen.

Disease Ontology:9 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia:66 Waterhouse?Friderichsen syndrome (WFS) or hemorrhagic adrenalitis or Fulminant meningococcemia, is... more...

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

About this section
Sources:
9Disease Ontology, 11DISEASES, 50Orphanet, 63UMLS, 44NIH Rare Diseases, 41NCIt, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

waterhouse-friderichsen syndrome 9 11 50 63
fatal pneumococcal waterhouse-friderichsen syndrome 44
waterhouse-friderichsen syndrome, meningococcal 63
meningococcal hemorrhagic adrenalitis 9
waterhouse–friderichsen syndrome 44
wolfram syndrome 63
wfs 9


External Ids:

Disease Ontology9 DOID:9931
NCIt41 C85225
MeSH36 D014884
MESH via Orphanet37 D014884
ICD10 via Orphanet27 A39.1+, E35.1*
SNOMED-CT via Orphanet60 36102002
UMLS via Orphanet64 C0043068
ICD1026 A39.1

Related Diseases for Waterhouse-Friderichsen Syndrome

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Waterhouse-Friderichsen Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 23)
idRelated DiseaseScoreTop Affiliating Genes
1wolfram syndrome30.0WFS1, CISD2
2meningitis10.8
3meningococcemia10.8
4influenza10.7
5sepsis10.6
6meningococcal meningitis10.6
7purpura10.6
8meningococcal infection10.6
9disseminated intravascular coagulation10.5
10bacteremia10.5
11acute adrenal insufficiency10.5
12cholera10.3
13congenital adrenal hyperplasia10.3
14necrotizing fasciitis10.3
15diarrhea10.3
16fasciitis10.3
17pericarditis10.3
18sickle cell disease10.3
19septic shock10.3
20wfs1-related disorders10.0
21nephritis10.0
22wolfram syndrome 210.0CISD2
23opa3-related 3-methylglutaconic aciduria10.0WFS1, CISD2

Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to waterhouse-friderichsen syndrome

Symptoms for Waterhouse-Friderichsen Syndrome

About this section

Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Waterhouse-Friderichsen Syndrome

Drug clinical trials:

Search ClinicalTrials for Waterhouse-Friderichsen Syndrome

Search NIH Clinical Center for Waterhouse-Friderichsen Syndrome

Search CenterWatch for Waterhouse-Friderichsen Syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

About this section

Anatomical Context for Waterhouse-Friderichsen Syndrome

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Waterhouse-Friderichsen Syndrome:

34
Adrenal gland, Skin, Spleen, Lung

Animal Models for Waterhouse-Friderichsen Syndrome or affiliated genes

About this section

Publications for Waterhouse-Friderichsen Syndrome

About this section
Sources:
53PubMed
See all sources

Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. (23814386)
2013
2
Waterhouse Friderichsen Syndrome Complicating Fulminant Enterobacter Cloacae Sepsis in a Preterm Infant: The Unresolved Issue of Corticosteroids. (24328998)
2013
3
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. (21772601)
2011
4
Fatal pneumococcal Waterhouse-Friderichsen syndrome in a vaccinated adult with congenital asplenia. (19751638)
2009
5
Medical image. Meningococcal septic shock with adrenal apoplexy--Waterhouse-Friderichsen syndrome. (16868589)
2006
6
Postmortem measurement of serum procalcitonin concentration in Waterhouse-Friderichsen syndrome. (12587602)
2002
7
Spontaneous Waterhouse-Friderichsen syndrome in a gang-housed baboon. (11515675)
2001
8
Waterhouse-Friderichsen syndrome after infection with group A streptococcus. (11702906)
2001
9
Reminder--necrotizing fasciitis complicated by Waterhouse-Friderichsen syndrome. (10454031)
1999
10
Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. (7560209)
1995
11
Waterhouse-Friderichsen syndrome resulting from colchicine overdose. (8258815)
1993
12
Group A beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome. (1528655)
1992
13
Waterhouse-Friderichsen syndrome without purpura due to Haemophilus influenzae group B. (3873065)
1985
14
Adrenal, cutaneous and myocardial lesions in fulminating endotoxinemia (Waterhouse-Friderichsen syndrome). (7134067)
1982
15
Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. (7229096)
1981
16
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an adult. (6977494)
1981
17
Chest infection associated with the Waterhouse-Friderichsen syndrome. (6790062)
1981
18
Fatal cholera-like diarrhea with Waterhouse-Friderichsen syndrome, sickle-cell trait, and hyposplenism. (335288)
1977
19
Adrenal lesions in calves dying from endotoxin shock, with special reference to the Waterhouse-Friderichsen syndrome. (858809)
1977
20
Waterhouse Friderichsen syndrome. (1207489)
1975
21
Waterhouse Friderichsen syndrome. Endotoxin shock treated with massive doses of cortisol. (4705280)
1973
22
The Waterhouse-Friderichsen syndrome and its orthopaedic consequences. (5081691)
1972
23
Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. (5118056)
1971
24
Waterhouse-Friderichsen syndrome induced by pneumococcemic shock. (5467531)
1970
25
The pathology of the Waterhouse-Friderichsen syndrome. (5504755)
1970
26
Fatal meningitis due to Moraxella duplex: report of a case with Waterhouse-Friderichsen syndrome. (5655280)
1968
27
Fulminating meningococcemia (Waterhouse-Friderichsen syndrome): report of two patients successfully treated with chemotherapy, vasopressors, and adrenal steroids. (13664537)
1959
28
WATERHOUSE-Friderichsen syndrome. (13856902)
1959
29
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. (13512121)
1958
30
THE WATERHOUSE-FRIDERICHSEN syndrome failure of hydrocortisone therapy. (13398680)
1957
31
The early diagnosis of the Waterhouse-Friderichsen syndrome. (13435437)
1957
32
Recovery from Waterhouse-Friderichsen syndrome associated with use of norepinephrine to combat shock. (13385639)
1957
33
Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome. (13322226)
1956
34
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
35
Waterhouse-Friderichsen syndrome (W.-F.S.) (14375664)
1955
36
Waterhouse-Friderichsen syndrome: report of a case with recovery. (14350471)
1955
37
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
38
Mima polymorpha as a causative agent in Waterhouse-Friderichsen syndrome. (13157230)
1954
39
The Waterhouse-Friderichsen syndrome. (13050387)
1953
40
Norepinephrine in the treatment of the Waterhouse-Friderichsen syndrome; report of a case. (13098452)
1953
41
A fatal case of Still's disease associated with Waterhouse-Friderichsen syndrome due to pneumococcal septicaemia. (13036557)
1953
42
The prolonged Waterhouse-Friderichsen syndrome with renal and myocardial insufficiency. (13031407)
1953
43
Lung: osseous emboli after spinal tap in a case of Waterhouse-Friderichsen syndrome complicating preeclamptic toxemia. (13094139)
1953
44
Waterhouse-Friderichsen syndrome; report of a case with recovery. (14947936)
1952
45
Waterhouse-Friderichsen syndrome associated with septic abortion and sickle cell disease. (13002737)
1952
46
A case of Waterhouse-Friderichsen syndrome with recovery following the use of cortisone, aqueous adrenal cortical extract and chemotherapy. (14918718)
1952
47
Nature of Waterhouse-Friderichsen syndrome; report of case with successful treatment with cortisone. (14850251)
1951
48
The Waterhouse-Friderichsen syndrome in the differential diagnosis of acute abdominal crises. (14782113)
1950
49
Massive gastro-intestinal hemorrhage in fulminating meningococcus meningitis (Waterhouse-Friderichsen syndrome) with recovery. (20246682)
1947
50
The Waterhouse-Friderichsen Syndrome: Report of Three Cases in Adults with Necropsy Findings. (21434244)
1945

Variations for Waterhouse-Friderichsen Syndrome

About this section

Expression for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Waterhouse-Friderichsen Syndrome

Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
See all sources

Compounds for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section

GO Terms for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Waterhouse-Friderichsen Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.0WFS1, CISD2
2endoplasmic reticulumGO:0057838.7WFS1, CISD2

Biological processes related to Waterhouse-Friderichsen Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular protein metabolic processGO:0442679.1WFS1, MVD

Molecular functions related to Waterhouse-Friderichsen Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.3MVD, CISD2

Products for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Waterhouse-Friderichsen Syndrome

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet