MCID: WTR001
MIFTS: 33

Waterhouse-Friderichsen Syndrome malady

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

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Sources:
66UMLS, 11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 37MeSH, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 28ICD10, 60SNOMED-CT
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Aliases & Descriptions for Waterhouse-Friderichsen Syndrome:

Name: Waterhouse-Friderichsen Syndrome 11 46 13 52 37 66
Fatal Pneumococcal Waterhouse-Friderichsen Syndrome 46 66
Waterhouse-Friderichsen Syndrome, Meningococcal 66
 
Meningococcal Hemorrhagic Adrenalitis 11
Wolfram Syndrome 66
Wfs 11

Classifications:



External Ids:

Disease Ontology11 DOID:9931
MeSH37 D014884
NCIt43 C85225
Orphanet52 ORPHA100067
ICD10 via Orphanet29 A39.1+, E35.1*
MESH via Orphanet38 D014884
UMLS via Orphanet67 C0043068
ICD1028 A39.1

Summaries for Waterhouse-Friderichsen Syndrome

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NIH Rare Diseases:46 Waterhouse–friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. it is usually caused by severe meningococcal infection or other severe, bacterial infection. symptoms include acute adrenal gland insufficiency, and profound shock. most patients with this condition are children, although adults may rarely be affected. it is deadly if not treated immediately. last updated: 2/4/2016

MalaCards based summary: Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to wolfram syndrome and acute adrenal insufficiency, and has symptoms including ataxia, seizures and tremor. An important gene associated with Waterhouse-Friderichsen Syndrome is WFS1 (Wolframin ER Transmembrane Glycoprotein). Affiliated tissues include adrenal gland, spleen and skin.

Disease Ontology:11 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia:69 Waterhouse–Friderichsen syndrome (WFS), hemorrhagic adrenalitis or fulminant meningococcemia is... more...

Related Diseases for Waterhouse-Friderichsen Syndrome

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Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to waterhouse-friderichsen syndrome

Symptoms for Waterhouse-Friderichsen Syndrome

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UMLS symptoms related to Waterhouse-Friderichsen Syndrome:


ataxia, seizures, tremor, dizziness, syncope, presyncope

Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Waterhouse-Friderichsen Syndrome


Cochrane evidence based reviews: waterhouse-friderichsen syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

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Anatomical Context for Waterhouse-Friderichsen Syndrome

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MalaCards organs/tissues related to Waterhouse-Friderichsen Syndrome:

34
Adrenal gland, Spleen, Skin, Lung

Animal Models for Waterhouse-Friderichsen Syndrome or affiliated genes

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Publications for Waterhouse-Friderichsen Syndrome

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Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
A Case of Waterhouse-Friderichsen Syndrome Resulting from an Invasive Pneumococcal Infection in a Patient with a Hypoplastic Spleen. (26942021)
2016
2
An autopsy case of pneumococcal Waterhouse-Friderichsen syndrome with possible functional asplenia/hyposplenia. (26261663)
2015
3
Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. (23814386)
2013
4
Waterhouse Friderichsen Syndrome Complicating Fulminant Enterobacter Cloacae Sepsis in a Preterm Infant: The Unresolved Issue of Corticosteroids. (24328998)
2013
5
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. (21772601)
2011
6
Medical image. Meningococcal septic shock with adrenal apoplexy--Waterhouse-Friderichsen syndrome. (16868589)
2006
7
Waterhouse-Friderichsen syndrome as a result of non-meningococcal infection. (14747454)
2004
8
Fatal Waterhouse-Friderichsen syndrome due to Ewingella americana infection. (12604997)
2003
9
Spontaneous Waterhouse-Friderichsen syndrome in a gang-housed baboon. (11515675)
2001
10
Waterhouse-Friderichsen syndrome after infection with group A streptococcus. (11702906)
2001
11
Waterhouse-Friderichsen syndrome secondary to Capnocytophaga canimorsus septicemia and demonstration of bacteremia by peripheral blood smear. (10835521)
2000
12
Reminder--necrotizing fasciitis complicated by Waterhouse-Friderichsen syndrome. (10454031)
1999
13
Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. (7560209)
1995
14
Waterhouse-Friderichsen syndrome resulting from colchicine overdose. (8258815)
1993
15
Group A beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome. (1528655)
1992
16
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an immunocompetent young adult. (2595428)
1989
17
Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. (7229096)
1981
18
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an adult. (6977494)
1981
19
Chest infection associated with the Waterhouse-Friderichsen syndrome. (6790062)
1981
20
Fatal cholera-like diarrhea with Waterhouse-Friderichsen syndrome, sickle-cell trait, and hyposplenism. (335288)
1977
21
Adrenal lesions in calves dying from endotoxin shock, with special reference to the Waterhouse-Friderichsen syndrome. (858809)
1977
22
Waterhouse Friderichsen syndrome. Endotoxin shock treated with massive doses of cortisol. (4705280)
1973
23
The Waterhouse-Friderichsen syndrome and its orthopaedic consequences. (5081691)
1972
24
Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. (5118056)
1971
25
Waterhouse-Friderichsen syndrome induced by pneumococcemic shock. (5467531)
1970
26
The pathology of the Waterhouse-Friderichsen syndrome. (5504755)
1970
27
Fatal meningitis due to Moraxella duplex: report of a case with Waterhouse-Friderichsen syndrome. (5655280)
1968
28
Skin sloughs in Waterhouse-Friderichsen syndrome. Case report. (4881013)
1968
29
Waterhouse-Friderichsen syndrome in varicella. (13772211)
1960
30
WATERHOUSE-Friderichsen syndrome. (13856902)
1959
31
Meningococcic meningitis and meningococcemia with probable Waterhouse-Friderichsen syndrome. (13514273)
1958
32
Recovery from Waterhouse-Friderichsen syndrome associated with use of norepinephrine to combat shock. (13385639)
1957
33
Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome. (13322226)
1956
34
Waterhouse-Friderichsen syndrome: report of a case with recovery. (14350471)
1955
35
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
36
Waterhouse-Friderichsen syndrome; a review of the literature and a report of two cases of fulminating meningococcic septicemia. (13199914)
1954
37
Waterhouse-Friderichsen syndrome. (13163651)
1954
38
The Waterhouse-Friderichsen syndrome. (13050387)
1953
39
A fatal case of Still's disease associated with Waterhouse-Friderichsen syndrome due to pneumococcal septicaemia. (13036557)
1953
40
The prolonged Waterhouse-Friderichsen syndrome with renal and myocardial insufficiency. (13031407)
1953
41
Waterhouse Friderichsen syndrome. (13071144)
1953
42
Meningococcus meningitis with massive hemorrhage of the adrenals' (Waterhouse-Friderichsen syndrome) complicating pregnancy with pre-eclamptic toxemia. (13016690)
1953
43
Nor-epinephrine in the treatment of acute meningococcemia with shock (Waterhouse-Friderichsen syndrome) and an evaluation of adrenocortical function. (13072798)
1953
44
Waterhouse-Friderichsen syndrome; report of a case with recovery. (14947936)
1952
45
A case of Waterhouse-Friderichsen syndrome with recovery following the use of cortisone, aqueous adrenal cortical extract and chemotherapy. (14918718)
1952
46
The Waterhouse-Friderichsen syndrome in the differential diagnosis of acute abdominal crises. (14782113)
1950
47
Waterhouse-Friderichsen syndrome complicated by acute pericarditis, with recovery. (20250341)
1947
48
Bilateral acute hemorrhagic necrosis of the adrenals (Waterhouse-Friderichsen syndrome) in a young child. (20245933)
1946
49
Bilateral acute hemorrhagic necrosis of the adrenals in a young child (a case of Waterhouse-Friderichsen syndrome). (21066827)
1946
50
Waterhouse-Friderichsen syndrome; report of a case. (21009674)
1945

Variations for Waterhouse-Friderichsen Syndrome

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Expression for genes affiliated with Waterhouse-Friderichsen Syndrome

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Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for genes affiliated with Waterhouse-Friderichsen Syndrome

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GO Terms for genes affiliated with Waterhouse-Friderichsen Syndrome

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Cellular components related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00057419.4CISD2, GIMAP5

Sources for Waterhouse-Friderichsen Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet