MCID: WTR001
MIFTS: 38

Waterhouse-Friderichsen Syndrome malady

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

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Sources:
65UMLS, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Waterhouse-Friderichsen Syndrome:

Name: Waterhouse-Friderichsen Syndrome 10 45 12 51 36 65
Fatal Pneumococcal Waterhouse-Friderichsen Syndrome 45 65
Waterhouse-Friderichsen Syndrome, Meningococcal 65
 
Meningococcal Hemorrhagic Adrenalitis 10
Wolfram Syndrome 65
Wfs 10

Classifications:



External Ids:

Disease Ontology10 DOID:9931
MeSH36 D014884
NCIt42 C85225
Orphanet51 100067
ICD10 via Orphanet28 A39.1+, E35.1*
MESH via Orphanet37 D014884
UMLS via Orphanet66 C0043068
ICD1027 A39.1
UMLS65 C0043068, C1403891, C2931288

Summaries for Waterhouse-Friderichsen Syndrome

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NIH Rare Diseases:45 Waterhouse–friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. it is usually caused by severe meningococcal infection or other severe, bacterial infection. symptoms include acute adrenal gland insufficiency, and profound shock. most patients with this condition are children, although adults may rarely be affected. it is deadly if not treated immediately. last updated: 2/4/2016

MalaCards based summary: Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to wolfram syndrome and acute adrenal insufficiency. An important gene associated with Waterhouse-Friderichsen Syndrome is WFS1 (Wolframin ER Transmembrane Glycoprotein). Affiliated tissues include adrenal gland, liver and t cells, and related mouse phenotypes are growth/size/body region and mortality/aging.

Disease Ontology:10 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia:68 Waterhouse–Friderichsen syndrome (WFS), hemorrhagic adrenalitis or fulminant meningococcemia is... more...

Related Diseases for Waterhouse-Friderichsen Syndrome

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Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to waterhouse-friderichsen syndrome

Symptoms for Waterhouse-Friderichsen Syndrome

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Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Waterhouse-Friderichsen Syndrome


Cochrane evidence based reviews: waterhouse-friderichsen syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

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Anatomical Context for Waterhouse-Friderichsen Syndrome

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MalaCards organs/tissues related to Waterhouse-Friderichsen Syndrome:

33
Adrenal gland, Liver, T cells, Prostate, Lung, Pituitary, Placenta

Animal Models for Waterhouse-Friderichsen Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Waterhouse-Friderichsen Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.1ARHGEF12, BARD1, CISD2, F2, PPT1, RFX6
2MP:00107685.9ARHGEF12, BARD1, CISD2, CLN3, CXCL12, F2

Publications for Waterhouse-Friderichsen Syndrome

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Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
3-O-methyldopa levels in newborns: Result of newborn screening for aromatic l-amino-acid decarboxylase deficiency. (27216367)
2016
2
Unusual association of turner syndrome and hypopituitarism in a Tunisian family. (27140594)
2016
3
Ecthyma gangrenosum in a preterm infant. (25649825)
2015
4
The changing epidemiological and complications profile of chronic suppurative otitis media in a developing country after two decades. (26611685)
2015
5
Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma. (25034527)
2014
6
Superficial siderosis and spinal intradural extramedullary cavernous angioma. (25130102)
2014
7
Diana Bilton: a pioneer in cystic fibrosis. (24429090)
2013
8
A case of recurrent psychosis during sickle cell disease crisis treated successfully with ziprasidone. (23302449)
2013
9
Langerhans/dendritic cell sarcoma arising from hairy cell leukemia: a rare phenomenon. (22234838)
2012
10
Effects of gender on the phenotype of CADASIL. (22033996)
2012
11
Expanding the clinical, pathological and MRI phenotype of DNM2- related centronuclear myopathy. (20227276)
2010
12
Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity. (19896793)
2010
13
Gene set analysis of lung samples provides insight into pathogenesis of progressive, fibrotic pulmonary sarcoidosis. (20194811)
2010
14
Pneumoscrotum due to perforated peptic ulcer previously sutured by laparoscopy. (20156121)
2010
15
Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters. (20552631)
2010
16
Binding of estrogen receptor alpha/beta heterodimers to chromatin in MCF-7 cells. (19376833)
2009
17
Effect of Abl-interacting protein 1 overexpression upon human gastric cancer cell proliferation in vitro]. (20193272)
2009
18
Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. (20002084)
2009
19
Noncommunicating tubular duplication of the upper pouch in esophageal atresia without fistula. (19635321)
2009
20
Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry. (18484746)
2008
21
Pure red cell aplasia in a patient of chronic granulocyte leukemia associated with imatinib. (17123082)
2007
22
Prediction of outcome in cancer patients with febrile neutropenia: comparison of the Multinational Association of Supportive Care in Cancer risk-index score with procalcitonin, C-reactive protein, serum amyloid A, and interleukins-1beta, -6, -8 and -10. (17944761)
2007
23
Case report of a Spanish patient with arrhythmogenic right ventricular cardiomyopathy and palmoplantar keratoderma without plakoglobin and desmoplakin gene modifications. (17045679)
2007
24
Oxidation-reduction potential and paraoxonase-arylesterase activity in trauma patients. (17662690)
2007
25
Postmenopausal advanced breast cancer: options for therapy after tamoxifen and aromatase inhibitors. (16504510)
2006
26
Effect of cholesterol depletion on exocytosis of alveolar type II cells. (16439800)
2006
27
Aspergillus fumigatus activate human corneal epithelial cells via Toll-like receptor 2 and 4]. (17081423)
2006
28
Structural details on mdm2-p53 interaction. (16159876)
2005
29
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
30
Insulin-like growth factor-1/insulin bypasses Pref-1/FA1-mediated inhibition of adipocyte differentiation. (12651852)
2003
31
Bonding efficacy of polyalkenoic acids to hydroxyapatite, enamel and dentin. (12615476)
2003
32
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. (12466124)
2002
33
Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. (11707570)
2001
34
The insulin hypoglycaemia and overnight metyrapone tests in the assessment of the hypothalamic-pituitary-adrenal axis following pituitary surgery. (10971447)
2000
35
PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. (11050243)
2000
36
Critical role of enhanced CD4 affinity in laboratory adaptation of human immunodeficiency virus type 1. (10875613)
2000
37
Management of pleural effusions. (10925561)
2000
38
Regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase. (10770941)
2000
39
Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism. (10525096)
1999
40
Blood conservation in hip trauma. (9917702)
1998
41
Prevention of hyperacute rejection by phosphatidylinositol-anchored mini-complement receptor type 1. (9777699)
1998
42
Prepro-neuropeptide Y mRNA and NPY binding sites in human inferior vagal ganglia. (9243632)
1997
43
The protective effect of allopurinol on cholestatic liver injury induced by bile duct ligation. (8843006)
1996
44
Scurvy in schizophrenia. (7796225)
1995
45
Case report 834: Chronic sclerosing osteomyelitis of the mandible with long bone periostitis. (8016677)
1994
46
Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells. (8096340)
1993
47
Hemicrania continua and symptomatic medication overuse. (8262795)
1993
48
Serum markers of immune activation and liver allograft rejection. (1618061)
1992
49
Production of experimental staphylococcal impetigo in mice. (1390457)
1992
50
Renal impairment, hypertension and encephalomalacia in an infant surviving severe intra-uterine anoxia. (13120838)
1953

Variations for Waterhouse-Friderichsen Syndrome

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Expression for genes affiliated with Waterhouse-Friderichsen Syndrome

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Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for genes affiliated with Waterhouse-Friderichsen Syndrome

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GO Terms for genes affiliated with Waterhouse-Friderichsen Syndrome

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Biological processes related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumen acidificationGO:000704210.2CLN3, PPT1
2double-strand break repairGO:000630210.0BARD1, WHSC1
3protein catabolic processGO:00301639.9CLN3, PPT1
4adult locomotory behaviorGO:00083449.7CXCL12, PPT1
5double-strand break repair via nonhomologous end joiningGO:00063039.7BARD1, WHSC1

Sources for Waterhouse-Friderichsen Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet