MCID: WTR001
MIFTS: 30

Waterhouse-Friderichsen Syndrome

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

MalaCards integrated aliases for Waterhouse-Friderichsen Syndrome:

Name: Waterhouse-Friderichsen Syndrome 12 49 55 41 14 69
Fatal Pneumococcal Waterhouse-Friderichsen Syndrome 49 69
Waterhouse-Friderichsen Syndrome, Meningococcal 69
Meningococcal Hemorrhagic Adrenalitis 12
Wfs 12

Classifications:

Orphanet: 55  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:9931
MeSH 41 D014884
NCIt 46 C85225
SNOMED-CT 64 154709005 267484005
Orphanet 55 ORPHA100067
MESH via Orphanet 42 D014884
UMLS via Orphanet 70 C0043068 C1403891
ICD10 via Orphanet 33 A39.1+ E35.1*
ICD10 32 A39.1

Summaries for Waterhouse-Friderichsen Syndrome

NIH Rare Diseases : 49 Waterhouse–Friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. It is usually caused by severe meningococcal infection or other severe, bacterial infection. Symptoms include acute adrenal gland insufficiency, and profound shock. Most patients with this condition are children, although adults may rarely be affected. It is deadly if not treated immediately. Last updated: 2/4/2016

MalaCards based summary : Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to acute adrenal insufficiency and wolfram syndrome 1. An important gene associated with Waterhouse-Friderichsen Syndrome is PSMB9 (Proteasome Subunit Beta 9). Affiliated tissues include adrenal gland, spleen and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia : 72 Waterhouse–Friderichsen syndrome (WFS) is defined as adrenal gland failure due to bleeding into the... more...

Related Diseases for Waterhouse-Friderichsen Syndrome

Diseases related to Waterhouse-Friderichsen Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 acute adrenal insufficiency 11.7
2 wolfram syndrome 1 11.1
3 wolfram syndrome 11.1
4 meningitis 10.6
5 meningococcemia 10.6
6 influenza 10.5
7 haemophilus influenzae 10.5
8 meningococcal meningitis 10.4
9 purpura 10.4
10 meningococcal infection 10.4
11 bacteremia 2 10.3
12 disseminated intravascular coagulation 10.3
13 kidney cortex necrosis 10.3
14 pneumonia 10.3
15 lipoid congenital adrenal hyperplasia 10.1
16 purpura fulminans 10.1
17 diarrhea 10.1
18 cholera 10.1
19 pericarditis 10.1
20 kidney papillary necrosis 10.1
21 fasciitis 10.1
22 necrotizing fasciitis 10.1
23 sickle cell disease 10.1
24 neisseria meningitidis infection 10.1
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0

Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to Waterhouse-Friderichsen Syndrome

Symptoms & Phenotypes for Waterhouse-Friderichsen Syndrome

GenomeRNAi Phenotypes related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.55 MVD
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.55 MVD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.55 EIF4A3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.55 MVD
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.55 MVD
6 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.55 EIF4A3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.55 MVD
8 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.55 EIF4A3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.55 MVD
10 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.55 EIF4A3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.55 EIF4A3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.55 MVD
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.55 EIF4A3 MVD
14 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.55 EIF4A3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 MVD
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 MVD

Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

Search Clinical Trials , NIH Clinical Center for Waterhouse-Friderichsen Syndrome

Cochrane evidence based reviews: waterhouse-friderichsen syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

Anatomical Context for Waterhouse-Friderichsen Syndrome

MalaCards organs/tissues related to Waterhouse-Friderichsen Syndrome:

38
Adrenal Gland, Spleen, Skin, Lung

Publications for Waterhouse-Friderichsen Syndrome

Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50) (show all 122)
# Title Authors Year
1
Waterhouse-Friderichsen syndrome due to Neisseria meningitidis infection in a young adult with thrombotic microangiopathy and eculizumab treatment: case report and review of management. ( 28213751 )
2017
2
A rare case of Waterhouse- Friderichsen syndrome during primary Varicella zoster infection. ( 29219830 )
2017
3
A Case of Waterhouse-Friderichsen Syndrome Resulting from an Invasive Pneumococcal Infection in a Patient with a Hypoplastic Spleen. ( 26942021 )
2016
4
Streptococcus Pneumoniae Detection Long Time After Death in a Fatal Case of Waterhouse-Friderichsen Syndrome. ( 28009598 )
2016
5
Fatal purpura fulminans and Waterhouse-Friderichsen syndrome from fulminant Streptococcus pneumoniae sepsis in an asplenic young adult. ( 27583208 )
2016
6
A rare case of Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an immunocompetent patient. ( 25676131 )
2015
7
An autopsy case of pneumococcal Waterhouse-Friderichsen syndrome with possible functional asplenia/hyposplenia. ( 26261663 )
2015
8
Fatal Waterhouse-Friderichsen syndrome due to serotype C Neisseria meningitidis in a young HIV negative MSM (men who have sex with men). ( 25267809 )
2014
9
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. ( 23716842 )
2013
10
Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. ( 23814386 )
2013
11
The significance of adrenal hemorrhage: undiagnosed Waterhouse-Friderichsen syndrome, a case series. ( 23458363 )
2013
12
Waterhouse Friderichsen Syndrome Complicating Fulminant Enterobacter Cloacae Sepsis in a Preterm Infant: The Unresolved Issue of Corticosteroids. ( 24328998 )
2013
13
A fatal case of streptococcal and meningococcal meningitis in a 2-years-old child occurring as Waterhouse-Friderichsen Syndrome. ( 23910860 )
2013
14
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. ( 21772601 )
2011
15
Waterhouse-friderichsen syndrome caused by invasive haemophilus influenzae type B infection in a previously healthy young man. ( 20191807 )
2010
16
Fatal pneumococcal Waterhouse-Friderichsen syndrome in a vaccinated adult with congenital asplenia. ( 19751638 )
2009
17
Medical image. Meningococcal septic shock with adrenal apoplexy--Waterhouse-Friderichsen syndrome. ( 16868589 )
2006
18
Case of Waterhouse Friderichsen Syndrome during outbreak of meningococcal disease in Delhi in May 2005. ( 16749283 )
2005
19
Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. ( 16177250 )
2005
20
Waterhouse-Friderichsen syndrome as a result of non-meningococcal infection. ( 14747454 )
2004
21
Fatal Waterhouse-Friderichsen syndrome due to Ewingella americana infection. ( 12604997 )
2003
22
Postmortem measurement of serum procalcitonin concentration in Waterhouse-Friderichsen syndrome. ( 12587602 )
2002
23
Fatal pneumococcal Waterhouse-Friderichsen syndrome. ( 11482865 )
2001
24
Waterhouse-Friderichsen syndrome. ( 11556316 )
2001
25
Images in clinical medicine. Waterhouse-Friderichsen syndrome. ( 11333994 )
2001
26
Waterhouse-Friderichsen syndrome after infection with group A streptococcus. ( 11702906 )
2001
27
Spontaneous Waterhouse-Friderichsen syndrome in a gang-housed baboon. ( 11515675 )
2001
28
Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis in meningococcal sepsis. ( 10922319 )
2000
29
Waterhouse-Friderichsen syndrome secondary to Capnocytophaga canimorsus septicemia and demonstration of bacteremia by peripheral blood smear. ( 10835521 )
2000
30
Reminder--necrotizing fasciitis complicated by Waterhouse-Friderichsen syndrome. ( 10454031 )
1999
31
Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. ( 7560209 )
1995
32
Lethal Waterhouse-Friderichsen syndrome in posttraumatic asplenia. ( 7473978 )
1995
33
Waterhouse-Friderichsen syndrome resulting from colchicine overdose. ( 8258815 )
1993
34
Fatal childhood pneumococcal Waterhouse-Friderichsen syndrome. ( 8451106 )
1993
35
Group A beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome. ( 1528655 )
1992
36
Fatal pneumococcal bacteremia with disseminated intravascular coagulation and Waterhouse-Friderichsen syndrome in a vaccinated splenectomized adult. Case report. ( 2368552 )
1990
37
Pneumococcal Waterhouse-Friderichsen syndrome despite a normal spleen. ( 2608604 )
1989
38
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an immunocompetent young adult. ( 2595428 )
1989
39
Haemophilus influenzae meningitis and Waterhouse-Friderichsen syndrome in an adult. ( 3738579 )
1986
40
Waterhouse-Friderichsen syndrome without purpura due to Haemophilus influenzae group B. ( 3873065 )
1985
41
Adrenal, cutaneous and myocardial lesions in fulminating endotoxinemia (Waterhouse-Friderichsen syndrome). ( 7134067 )
1982
42
Chest infection associated with the Waterhouse-Friderichsen syndrome. ( 6790062 )
1981
43
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an adult. ( 6977494 )
1981
44
Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. ( 7229096 )
1981
45
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b. ( 316349 )
1979
46
Adrenal lesions in calves dying from endotoxin shock, with special reference to the Waterhouse-Friderichsen syndrome. ( 858809 )
1977
47
Sudden death due to Waterhouse-Friderichsen syndrome and purulent leptomeningitis caused by Acinetobacter calcoaceticus (Mima polymorpha). ( 883428 )
1977
48
Fatal cholera-like diarrhea with Waterhouse-Friderichsen syndrome, sickle-cell trait, and hyposplenism. ( 335288 )
1977
49
Animal model of human disease. Waterhouse-Friderichsen syndrome. Animal model: Acrylonitrile-induced adrenal apoplexy. ( 1258981 )
1976
50
Waterhouse Friderichsen syndrome. ( 1207489 )
1975

Variations for Waterhouse-Friderichsen Syndrome

Expression for Waterhouse-Friderichsen Syndrome

Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for Waterhouse-Friderichsen Syndrome

GO Terms for Waterhouse-Friderichsen Syndrome

Sources for Waterhouse-Friderichsen Syndrome

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