MCID: WTR001
MIFTS: 37

Waterhouse-Friderichsen Syndrome malady

Rare diseases, Infectious diseases, Endocrine diseases categories

Summaries for Waterhouse-Friderichsen Syndrome

About this section


NIH Rare Diseases:43 Waterhouse–friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. it is caused by severe meningococcal infection or other severe, bacterial infection. symptoms include acute adrenal gland insufficiency, and profound shock. most patients with this condition are children, although adults may rarely be affected. it is deadly if not treated immediately. last updated: 1/8/2010

MalaCards based summary: Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to wolfram syndrome and meningitis. An important gene associated with Waterhouse-Friderichsen Syndrome is CISD2 (CDGSH iron sulfur domain 2), and among its related pathways is Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. Affiliated tissues include adrenal gland, spleen and skin.

Disease Ontology:10 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia:65 Waterhouse?Friderichsen syndrome (WFS) or hemorrhagic adrenalitis or Fulminant meningococcemia, is... more...

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

About this section
Sources:
62UMLS, 10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 49Orphanet, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Waterhouse-Friderichsen Syndrome, Aliases & Descriptions:

Name: Waterhouse-Friderichsen Syndrome 10 43 12 49 62
Fatal Pneumococcal Waterhouse-Friderichsen Syndrome 43 62
Waterhouse-Friderichsen Syndrome, Meningococcal 62
 
Meningococcal Hemorrhagic Adrenalitis 10
Wolfram Syndrome 62
Wfs 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology10 DOID:9931
NCIt40 C85225
MeSH35 D014884
Orphanet49 100067
MESH via Orphanet36 D014884
ICD10 via Orphanet28 A39.1+, E35.1*
UMLS via Orphanet63 C0043068
ICD1027 A39.1

Related Diseases for Waterhouse-Friderichsen Syndrome

About this section

Diseases related to Waterhouse-Friderichsen Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1wolfram syndrome30.3WFS1, CISD2
2meningitis10.8
3meningococcemia10.8
4influenza10.8
5haemophilus influenzae10.7
6meningococcal meningitis10.6
7purpura10.6
8meningococcal infection10.6
9bacteremia10.5
10disseminated intravascular coagulation10.5
11acute adrenal insufficiency10.5
12cholera10.3
13congenital adrenal hyperplasia10.3
14necrotizing fasciitis10.3
15diarrhea10.3
16fasciitis10.3
17pericarditis10.3
18sickle cell disease10.3
19wfs1-related disorders10.1
20nephritis10.1
21wolfram syndrome 210.0CISD2
223-methylglutaconic aciduria, type iii10.0WFS1, CISD2

Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to waterhouse-friderichsen syndrome

Symptoms for Waterhouse-Friderichsen Syndrome

About this section

Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Waterhouse-Friderichsen Syndrome

Search NIH Clinical Center for Waterhouse-Friderichsen Syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

About this section

Anatomical Context for Waterhouse-Friderichsen Syndrome

About this section

MalaCards organs/tissues related to Waterhouse-Friderichsen Syndrome:

33
Adrenal gland, Spleen, Skin, Lung

Animal Models for Waterhouse-Friderichsen Syndrome or affiliated genes

About this section

Publications for Waterhouse-Friderichsen Syndrome

About this section

Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Fatal Waterhouse-Friderichsen syndrome due to serotype C Neisseria meningitidis in a young HIV negative MSM (men who have sex with men). (25267809)
2014
2
Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. (23814386)
2013
3
Waterhouse Friderichsen Syndrome Complicating Fulminant Enterobacter Cloacae Sepsis in a Preterm Infant: The Unresolved Issue of Corticosteroids. (24328998)
2013
4
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. (21772601)
2011
5
Fatal pneumococcal Waterhouse-Friderichsen syndrome in a vaccinated adult with congenital asplenia. (19751638)
2009
6
Medical image. Meningococcal septic shock with adrenal apoplexy--Waterhouse-Friderichsen syndrome. (16868589)
2006
7
Postmortem measurement of serum procalcitonin concentration in Waterhouse-Friderichsen syndrome. (12587602)
2002
8
Spontaneous Waterhouse-Friderichsen syndrome in a gang-housed baboon. (11515675)
2001
9
Waterhouse-Friderichsen syndrome after infection with group A streptococcus. (11702906)
2001
10
Reminder--necrotizing fasciitis complicated by Waterhouse-Friderichsen syndrome. (10454031)
1999
11
Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. (7560209)
1995
12
Waterhouse-Friderichsen syndrome resulting from colchicine overdose. (8258815)
1993
13
Group A beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome. (1528655)
1992
14
Waterhouse-Friderichsen syndrome without purpura due to Haemophilus influenzae group B. (3873065)
1985
15
Adrenal, cutaneous and myocardial lesions in fulminating endotoxinemia (Waterhouse-Friderichsen syndrome). (7134067)
1982
16
Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. (7229096)
1981
17
Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an adult. (6977494)
1981
18
Chest infection associated with the Waterhouse-Friderichsen syndrome. (6790062)
1981
19
Fatal cholera-like diarrhea with Waterhouse-Friderichsen syndrome, sickle-cell trait, and hyposplenism. (335288)
1977
20
Adrenal lesions in calves dying from endotoxin shock, with special reference to the Waterhouse-Friderichsen syndrome. (858809)
1977
21
Waterhouse Friderichsen syndrome. (1207489)
1975
22
Waterhouse Friderichsen syndrome. Endotoxin shock treated with massive doses of cortisol. (4705280)
1973
23
The Waterhouse-Friderichsen syndrome and its orthopaedic consequences. (5081691)
1972
24
Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. (5118056)
1971
25
Waterhouse-Friderichsen syndrome induced by pneumococcemic shock. (5467531)
1970
26
The pathology of the Waterhouse-Friderichsen syndrome. (5504755)
1970
27
Fatal meningitis due to Moraxella duplex: report of a case with Waterhouse-Friderichsen syndrome. (5655280)
1968
28
Fulminating meningococcemia (Waterhouse-Friderichsen syndrome): report of two patients successfully treated with chemotherapy, vasopressors, and adrenal steroids. (13664537)
1959
29
WATERHOUSE-Friderichsen syndrome. (13856902)
1959
30
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. (13512121)
1958
31
THE WATERHOUSE-FRIDERICHSEN syndrome failure of hydrocortisone therapy. (13398680)
1957
32
The early diagnosis of the Waterhouse-Friderichsen syndrome. (13435437)
1957
33
Recovery from Waterhouse-Friderichsen syndrome associated with use of norepinephrine to combat shock. (13385639)
1957
34
Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome. (13322226)
1956
35
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
36
Waterhouse-Friderichsen syndrome (W.-F.S.) (14375664)
1955
37
Waterhouse-Friderichsen syndrome: report of a case with recovery. (14350471)
1955
38
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
39
Mima polymorpha as a causative agent in Waterhouse-Friderichsen syndrome. (13157230)
1954
40
The Waterhouse-Friderichsen syndrome. (13050387)
1953
41
Norepinephrine in the treatment of the Waterhouse-Friderichsen syndrome; report of a case. (13098452)
1953
42
A fatal case of Still's disease associated with Waterhouse-Friderichsen syndrome due to pneumococcal septicaemia. (13036557)
1953
43
The prolonged Waterhouse-Friderichsen syndrome with renal and myocardial insufficiency. (13031407)
1953
44
Lung: osseous emboli after spinal tap in a case of Waterhouse-Friderichsen syndrome complicating preeclamptic toxemia. (13094139)
1953
45
Waterhouse-Friderichsen syndrome; report of a case with recovery. (14947936)
1952
46
Waterhouse-Friderichsen syndrome associated with septic abortion and sickle cell disease. (13002737)
1952
47
A case of Waterhouse-Friderichsen syndrome with recovery following the use of cortisone, aqueous adrenal cortical extract and chemotherapy. (14918718)
1952
48
The Waterhouse-Friderichsen syndrome in the differential diagnosis of acute abdominal crises. (14782113)
1950
49
Massive gastro-intestinal hemorrhage in fulminating meningococcus meningitis (Waterhouse-Friderichsen syndrome) with recovery. (20246682)
1947
50
The Waterhouse-Friderichsen Syndrome: Report of Three Cases in Adults with Necropsy Findings. (21434244)
1945

Variations for Waterhouse-Friderichsen Syndrome

About this section

Expression for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section

Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section

Compounds for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section

GO Terms for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section

Cellular components related to Waterhouse-Friderichsen Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057899.0WFS1, CISD2
2endoplasmic reticulumGO:00057838.7WFS1, CISD2

Biological processes related to Waterhouse-Friderichsen Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular protein metabolic processGO:00442679.1WFS1, MVD

Molecular functions related to Waterhouse-Friderichsen Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428039.3MVD, CISD2

Products for genes affiliated with Waterhouse-Friderichsen Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Waterhouse-Friderichsen Syndrome

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet