MCID: WDH001
MIFTS: 31

Wdha Syndrome

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Wdha Syndrome

MalaCards integrated aliases for Wdha Syndrome:

Name: Wdha Syndrome 49 51
Pancreatic Cholera 49 69
Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome 49
Verner-Morrison Syndrome 49

Classifications:



Summaries for Wdha Syndrome

MalaCards based summary : Wdha Syndrome, also known as pancreatic cholera, is related to vipoma and pancreatic cholera. An important gene associated with Wdha Syndrome is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Neuroscience and G alpha (s) signalling events. The drugs Pancreatic Polypeptide and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and bone.

Related Diseases for Wdha Syndrome

Diseases related to Wdha Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 vipoma 31.1 CALCA SST VIP
2 pancreatic cholera 30.5 CALCA SST VIP
3 pheochromocytoma 29.2 CALCA SST VIP
4 pancreatitis 10.2
5 diarrhea 10.0
6 hypokalemia 10.0
7 leprosy 2 10.0 CALCA VIP
8 vasomotor rhinitis 10.0 CALCA VIP
9 cluster headache 10.0 CALCA VIP
10 urticaria pigmentosa 10.0 CALCA VIP
11 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.9
12 diffuse pulmonary fibrosis 9.9 CALCA VIP
13 pancreatic somatostatinoma 9.9 CALCA SST
14 pancreatic islet cell tumors 9.9 CALCA SST
15 duodenal somatostatinoma 9.9 CALCA SST
16 prolactin producing pituitary tumor 9.8 CALCA SST
17 carcinoid syndrome 9.8 CALCA SST
18 adenoma 9.8
19 adenoma of the pancreas 9.8
20 neurofibromatosis, type iv, of riccardi 9.8
21 insulinoma 9.8
22 ganglioneuroblastoma 9.8
23 postgastrectomy syndrome 9.8 SST VIP
24 fibrous dysplasia 9.8 CALCA SST
25 glucagonoma 9.8 SST VIP
26 secretory diarrhea 9.7 SST VIP
27 cryptosporidiosis 9.7 SST VIP
28 binswanger's disease 9.7 SST VIP
29 paraganglioma 9.7 CALCA SST
30 gastrinoma 9.7 SST VIP
31 thyroid carcinoma, familial medullary 9.7 CALCA SST
32 constipation 9.7 SST VIP
33 hyperprolactinemia 9.7 SST VIP
34 migraine with or without aura 1 9.7 CALCA VIP
35 multiple endocrine neoplasia, type i 9.6 SST VIP
36 neuroendocrine tumor 9.6 CALCA SST
37 pertussis 9.6 SST VIP
38 thyroid cancer, nonmedullary, 2 9.6 CALCA SST
39 pulmonary hypertension 9.5 CALCA VIP
40 somatostatinoma 9.4 CALCA SST VIP
41 islet cell tumor 9.4 CALCA SST VIP
42 endocrine gland cancer 9.4 CALCA SST VIP
43 small cell cancer of the lung 9.4 CALCA SST VIP

Graphical network of the top 20 diseases related to Wdha Syndrome:



Diseases related to Wdha Syndrome

Symptoms & Phenotypes for Wdha Syndrome

Drugs & Therapeutics for Wdha Syndrome

Drugs for Wdha Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pancreatic Polypeptide Investigational Phase 4,Phase 2,Phase 3,Phase 1 59763-91-6
2 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
3
Oxaliplatin Approved, Investigational Phase 2, Phase 3,Phase 1 61825-94-3 43805 6857599 5310940 9887054
4
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
5
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
6
Levoleucovorin Approved, Investigational Phase 2, Phase 3,Phase 1 68538-85-2
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
8
leucovorin Approved, Nutraceutical Phase 2, Phase 3, Phase 1 58-05-9 143 6006
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
10 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
11 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
12 Immunosuppressive Agents Phase 2, Phase 3
13 Antimetabolites Phase 2, Phase 3,Phase 1
14 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 1
15 Analgesics Phase 3
16 Central Nervous System Depressants Phase 3
17 Adjuvants, Anesthesia Phase 3
18 Narcotics Phase 3
19 Analgesics, Opioid Phase 3
20 Anesthetics Phase 3
21 Anesthetics, General Phase 3
22 Anesthetics, Intravenous Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Folate Nutraceutical Phase 2, Phase 3
25 Vitamin B9 Nutraceutical Phase 2, Phase 3
26 Cola Nutraceutical Phase 3,Phase 2,Phase 1
27
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
28
Melphalan Approved Phase 2 148-82-3 460612 4053
29
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
30
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
31
Octreotide Approved, Investigational Phase 2,Phase 1 83150-76-9 6400441 383414
32
Pancrelipase Approved, Investigational Phase 2 53608-75-6
33
Somatostatin Approved, Investigational Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
34
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
35
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
36
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
37 pancreatin Phase 2
38 Alkylating Agents Phase 2
39 topoisomerase I inhibitors Phase 2
40 Retinol palmitate Phase 2
41 Micronutrients Phase 2
42 Gastrointestinal Agents Phase 2,Phase 1
43 Topoisomerase Inhibitors Phase 2
44 Trace Elements Phase 2
45 Nicotinic Acids Phase 2
46 Vitamin B Complex Phase 2
47 Hormones Phase 2,Phase 1
48 Vitamins Phase 2
49 Anti-Bacterial Agents Phase 2
50 Antidotes Phase 2,Phase 1

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
2 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3 5-fluorouracil;leucovorin;oxaliplatin
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00131911 Phase 2 sorafenib tosylate
5 Gefitinib in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00075439 Phase 2 gefitinib
6 Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery Completed NCT00416767 Phase 2 fluorouracil;irinotecan hydrochloride;leucovorin calcium
7 AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors Completed NCT00427349 Phase 2 AMG 706;octreotide
8 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
9 Thalidomide in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00027638 Phase 2 thalidomide
10 Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors Terminated NCT00466856 Phase 2 octreotide acetate
11 Vatalanib and Octreotide in Treating Patients With Progressive Neuroendocrine Tumors Withdrawn NCT00227773 Phase 2 octreotide acetate;vatalanib
12 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
13 Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Completed NCT00005842 Phase 1 tipifarnib
14 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
15 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
16 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1

Search NIH Clinical Center for Wdha Syndrome

Genetic Tests for Wdha Syndrome

Anatomical Context for Wdha Syndrome

MalaCards organs/tissues related to Wdha Syndrome:

38
Liver, Pancreas, Bone, Pancreatic Islet, Lung

Publications for Wdha Syndrome

Articles related to Wdha Syndrome:

(show all 25)
# Title Authors Year
1
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. ( 19488018 )
2009
2
VIPoma with expression of both VIP and VPAC1 receptors in a patient with WDHA syndrome. ( 19184565 )
2009
3
A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome. ( 21490894 )
2008
4
Hypokalemic rhabdomyolysis due to WDHA syndrome caused by VIP-producing composite pheochromocytoma: a case in neurofibromatosis type 1. ( 16027147 )
2005
5
A calcitonin and vasoactive intestinal peptide-producing pancreatic endocrine tumor associated with the WDHA syndrome. ( 14716055 )
2003
6
A multihormonal tumor of the pancreas producing neurotensin associated with the WDHA syndrome. Histology, histochemistry and origin. ( 2856535 )
1986
7
Pancreatic endocrine tumours associated with WDHA syndrome. An immunohistochemical and electron microscopic study. ( 2579503 )
1985
8
The WDHA syndrome: clinical and laboratory data on 28 Japanese cases. ( 6473165 )
1984
9
The exocrine pancreas of patients with WDHA syndrome. A light and electron microscopical study. ( 6471149 )
1984
10
WDHA syndrome caused by VIP-producing ganglioneuroblastoma. ( 6288909 )
1982
11
Effects fo streptozotocin in the WDHA syndrome not amenable to radical surgery. ( 6253557 )
1980
12
Angiographic diagnosis of a pancreatic islet tumor in a patient with the WDHA syndrome. ( 6252088 )
1980
13
Effects of streptozotocin in the WDHA syndrome not amenable to radical surgery. ( 6152975 )
1980
14
Clinical and hormonal aspects of the watery diarrhea-hypokalemia-achlorhydria (WDHA) syndrome due to vasoactive intestinal polypeptide (VIP)-producing tumor. ( 7014208 )
1980
15
VIP and the WDHA syndrome. ( 437409 )
1979
16
WDHA syndrome caused by pheochromocytoma: report of a case. ( 657943 )
1978
17
A pancreatic-polypeptide-producing tumour associated with the WDHA syndrome. ( 151327 )
1978
18
Angiographic demonstration of a vasoactive intestinal polypeptide-secreting pheochromocytoma in a patient with WDHA syndrome. ( 413408 )
1978
19
The VIPoma: further confirmation of VIP as the hormonal agent in the WDHA syndrome. ( 998869 )
1976
20
Angiographic demonstration of a pancreatic "vipoma" in the WDHA syndrome. ( 187070 )
1976
21
Watery diarrhoea (WDHA) syndrome associated with carcinoma of the lung. ( 193482 )
1976
22
Radiologic and pathologic characteristics of the WDHA syndrome. ( 183523 )
1976
23
Editorial: WDHA-syndrome and gastric secretory inhibitors. ( 4851596 )
1974
24
Islet-cell adenoma of the pancreas with reversible watery diarrhea and hypokalemia. WDHA syndrome. ( 4313557 )
1970
25
Bioassay for gastric secretory inhibitor in extract of pancreatic tumour from patient with WDHA-syndrome. ( 5455828 )
1970

Variations for Wdha Syndrome

Expression for Wdha Syndrome

Search GEO for disease gene expression data for Wdha Syndrome.

Pathways for Wdha Syndrome

Pathways related to Wdha Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 CALCA VIP
2 10.79 CALCA VIP

GO Terms for Wdha Syndrome

Cellular components related to Wdha Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.62 CALCA SST

Biological processes related to Wdha Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.43 CALCA SST VIP
2 cell-cell signaling GO:0007267 9.32 CALCA SST
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.16 CALCA VIP
4 response to heat GO:0009408 8.96 CALCA SST
5 regulation of receptor activity GO:0010469 8.8 CALCA SST VIP

Molecular functions related to Wdha Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA SST VIP

Sources for Wdha Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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