WSS
MCID: WVR003
MIFTS: 18

Weaver Syndrome 1 (WSS) malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Fetal diseases, Bone diseases, Mental diseases

Aliases & Classifications for Weaver Syndrome 1

Aliases & Descriptions for Weaver Syndrome 1:

Name: Weaver Syndrome 1 24
Weaver-Smith Syndrome 24
Weaver Syndrome 69
Wvs1 24
Wss 24

Classifications:



Summaries for Weaver Syndrome 1

MalaCards based summary : Weaver Syndrome 1, also known as weaver-smith syndrome, is related to woodhouse-sakati syndrome and weaver syndrome, and has symptoms including muscle spasticity An important gene associated with Weaver Syndrome 1 is NSD1 (Nuclear Receptor Binding SET Domain Protein 1). The drugs Azithromycin and Tobramycin have been mentioned in the context of this disorder.

Related Diseases for Weaver Syndrome 1

Diseases in the Weaver Syndrome family:

Weaver Syndrome 1 Ezh2-Related Weaver Syndrome

Diseases related to Weaver Syndrome 1 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 woodhouse-sakati syndrome 11.3
2 weaver syndrome 10.9
3 znf674-related x-linked mental retardation 9.8 ATP6V0A2 NSD1

Symptoms & Phenotypes for Weaver Syndrome 1

UMLS symptoms related to Weaver Syndrome 1:


muscle spasticity

Drugs & Therapeutics for Weaver Syndrome 1

Drugs for Weaver Syndrome 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
2
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
3
Carbon monoxide Approved Phase 4,Phase 1 630-08-0 281
4 Neurotransmitter Agents Phase 4,Phase 1
5 Antidepressive Agents Phase 4
6 Antidepressive Agents, Second-Generation Phase 4
7 Psychotropic Drugs Phase 4
8 Vaccines Phase 4,Phase 2
9 Anti-Bacterial Agents Phase 4,Phase 1
10 Anti-Infective Agents Phase 4
11 Antimetabolites Phase 4,Phase 1
12 Tryptophan Nutraceutical Phase 4
13
Levodopa Approved Phase 3 59-92-7 6047
14
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
15
Treprostinil Approved, Investigational Phase 2, Phase 3 81846-19-7 54786 6918140
16 Thrombin Phase 3
17 Coagulants Phase 3
18 Gelatin Sponge, Absorbable Phase 3
19 Hemostatics Phase 3,Phase 2
20 Dihydroxyphenylalanine Phase 3
21 Pharmaceutical Solutions Phase 2, Phase 3
22 Alkylating Agents Phase 3
23 Antihypertensive Agents Phase 2, Phase 3
24 Antineoplastic Agents, Alkylating Phase 3
25
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
26
Phenylephrine Approved Phase 2 59-42-7 6041
27
Oxymetazoline Approved Phase 2 1491-59-4 4636
28
Calcium carbonate Approved Phase 1, Phase 2 471-34-1
29
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
30
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
31
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
32
Gallium nitrate Approved, Investigational Phase 2 13494-90-1 61635
33 Anesthetics Phase 2
34 Anesthetics, Local Phase 2
35 Epinephryl borate Phase 2
36 Racepinephrine Phase 2
37 Bone Density Conservation Agents Phase 1, Phase 2,Early Phase 1
38 Calcium, Dietary Phase 1, Phase 2,Early Phase 1
39 Orange Nutraceutical Phase 2
40
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
41
Nicotine Approved Phase 1 54-11-5 942 89594
42
Etidronic acid Approved Phase 1 7414-83-7, 2809-21-4 3305
43
Camptothecin Experimental Phase 1 7689-03-4
44
Genistein Investigational Phase 1 446-72-0 5280961
45 topoisomerase I inhibitors Phase 1
46 Topoisomerase Inhibitors Phase 1
47 Antineoplastic Agents, Phytogenic Phase 1
48
Equol Phase 1 531-95-3 91469
49 Risedronate Sodium Phase 1 115436-72-1
50 calcium channel blockers Phase 1

Interventional clinical trials:

(show all 50)
id Name Status NCT ID Phase
1 Double Blind Study of Trp01 in Patients With Alzheimer's Disease Completed NCT00202124 Phase 4
2 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Recruiting NCT02783170 Phase 4
3 Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With CF Recruiting NCT02677701 Phase 4
4 One vs. Three Hyperbaric Oxygen Treatments for Acute Carbon Monoxide Poisoning Active, not recruiting NCT00465855 Phase 4
5 Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial Completed NCT00056563 Phase 3
6 Study of Recombinant Human Thrombin for Bleeding During Surgery Completed NCT00245336 Phase 3
7 Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma Recruiting NCT02546102 Phase 3
8 Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE Recruiting NCT02630316 Phase 2, Phase 3
9 Safety and Efficacy Study of TNX-650 to Treat Refractory Hodgkin's Lymphoma Unknown status NCT00441818 Phase 1, Phase 2
10 Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea Completed NCT00503802 Phase 2
11 Fructooligosaccharide and Calcium Absorption in Adolescent Girls Completed NCT01005927 Phase 1, Phase 2
12 A Pilot Study of GWP42003 in the Symptomatic Treatment of Ulcerative Colitis (GWID10160) Completed NCT01562314 Phase 2
13 Girls In Recovery From Life Stress (GIRLS) Study Completed NCT00751946 Phase 2
14 Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL Recruiting NCT02576561 Phase 2
15 A Pilot Study of Genetically Engineered NY-ESO-1 Specific NY-ESO-1ᶜ²⁵⁹T in HLA-A2+ Patients With Synovial Sarcoma Recruiting NCT01343043 Phase 1, Phase 2
16 A Phase 2 IV Gallium Study for Patients With Cystic Fibrosis (IGNITE Study) Recruiting NCT02354859 Phase 2
17 Study to Evaluate the Safety and Tolerability of GBT440 Administered to Subjects With IPF Recruiting NCT02846324 Phase 2
18 Hyperbaric Oxygen for Civilian Post-concussive Syndrome Not yet recruiting NCT01986205 Phase 2
19 Safety Study of IHL-305 (Irinotecan Liposome Injection) to Treat Advanced Solid Tumors Unknown status NCT00364143 Phase 1
20 Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer Completed NCT01457469 Phase 1
21 Isoflavones for Promoting Calcium Absorption and Preventing Bone Loss in Post Menopausal Women Completed NCT00244907 Phase 1
22 Hyperbaric Oxygen, Neutrophil-oxidative Burst, and Cytokines Recruiting NCT02563678 Phase 1
23 Bioavailability of Potassium From Potatoes and Potassium Gluconate Unknown status NCT01881295
24 Integrated Infectious Disease Capacity-Building Evaluation Completed NCT01190540
25 Galactooligosaccharide (GOS) Supplementation and Calcium Absorption in Girls Completed NCT01263847 Early Phase 1
26 Calcium Metabolism in Asian Adolescents Completed NCT00591708
27 Effect of Calcium Supplement Particle Size and Vitamin D Supplement on Calcium Retention in Adolescent Girls Completed NCT01005381
28 Hypobaria and Traumatic Pneumothorax Completed NCT01670942
29 Prospective, Non-Randomized Evaluation of Carbon Dioxide Gas as a Contrast Agent in Comparison With Iodinated Contrast in Endovascular Aneurysm Repair Completed NCT00520416
30 Comprehensive Support for Alzheimer's Disease Caregivers Completed NCT00362284
31 Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea Completed NCT00089752
32 Effect of Sodium Intake on Calcium Retention in Girls Completed NCT01564238
33 Calcium Metabolism in Mexican American Adolescents Completed NCT01277185
34 Vitamin D Deficiency in Elderly African American Women in Central Texas Completed NCT01971411
35 Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients Completed NCT01434342
36 Hesperidin and Bone Health in Postmenopausal Women Completed NCT01881204
37 DASH-Sodium Trial in Adolescents Recruiting NCT02993458
38 Clinical Trial Evaluating Acutrak Headless Compression Screw Fixation of Medial Malleolus Fractures Recruiting NCT03061279
39 Retention of Potassium From Potatoes and Potassium Gluconate, and the Effect on Blood Pressure. Recruiting NCT02697708
40 Can the Memory Support Intervention Improve Depression Outcome Following Cognitive Therapy? Recruiting NCT02938559
41 Preparatory Work to Assess Adherence to Oral Chemotherapy Recruiting NCT02895542
42 Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1) Recruiting NCT02777528
43 Compassionate Use of IV Fish Oil for Parenteral Nutrition (PN) Liver Injury Recruiting NCT01425567
44 Overactive Bladder Treatment Using StimRouter Neuromodulation System: A Prospective Randomized Trial Recruiting NCT02873312
45 Indomethacin PK and PD Therapy in Pregnancy Recruiting NCT02451228
46 Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Recruiting NCT02089217
47 mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms Active, not recruiting NCT01611194
48 Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder Active, not recruiting NCT02672111
49 BAROSTIM NEO HTN Pivotal Trial Active, not recruiting NCT01679132
50 Effect of Blueberries on Bone Turnover Not yet recruiting NCT02630797 Early Phase 1

Search NIH Clinical Center for Weaver Syndrome 1

Genetic Tests for Weaver Syndrome 1

Genetic tests related to Weaver Syndrome 1:

id Genetic test Affiliating Genes
1 Weaver Syndrome 1 24 NSD1

Anatomical Context for Weaver Syndrome 1

Publications for Weaver Syndrome 1

Variations for Weaver Syndrome 1

Expression for Weaver Syndrome 1

Search GEO for disease gene expression data for Weaver Syndrome 1.

Pathways for Weaver Syndrome 1

GO Terms for Weaver Syndrome 1

Sources for Weaver Syndrome 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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