Wegener Granulomatosis malady
Categories: Rare diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Immune diseases, Skin diseases
Aliases & Descriptions for Wegener Granulomatosis:
Orphanet epidemiological data:52
granulomatosis with polyangiitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-5/10000 (Sweden),1-9/1000000 (Germany),1-9/100000 (France),1-9/100000 (Sweden),1-9/100000 (Norway),1-9/100000 (Australia),1-9/100000 (New Zealand),1-9/100000 (United States),1-9/100000 (China),1-9/1000000 (Lithuania),1-9/1000000 (Greece),1-9/1000000 (Italy),1-9/1000000 (Canada),1-9/1000000 (Japan),<1/1000000 (Taiwan, Province of China),1-9/100000 (Italy),1-5/10000 (Denmark); Age of onset: All ages; Age of death: any age
Global: Rare diseases
Anatomical: Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Immune diseases, Skin diseases
ICD10: 29 28
Rare neurological diseases
Rare circulatory system diseases
Rare renal diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases
MedlinePlus:36 Granulomatosis with polyangiitis (gpa), previously known as wegener's granulomatosis, is a rare disease. it is a type of vasculitis, or inflammation of the blood vessels. the inflammation limits the flow of blood to important organs, causing damage. it can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs, and kidneys. the cause of gpa is unknown. it can affect people at any age. men and women are equally affected. it is more common in whites. symptoms may include joint pain, weakness, tiredness, and cold symptoms such as a runny nose that doesn't get better. doctors use blood tests, chest x-rays, and biopsies to diagnose gpa and rule out other causes of the symptoms. early treatment is important. most people improve with medicines to slow or stop the inflammation. nih: national institute of allergy and infectious diseases
MalaCards based summary: Wegener Granulomatosis, also known as granulomatosis with polyangiitis, is related to churg-strauss syndrome and mononeuritis, and has symptoms including abnormality of the oral cavity, sinusitis and epistaxis. An important gene associated with Wegener Granulomatosis is WG (Wegener Granulomatosis), and among its related pathways are C-MYB transcription factor network and amb2 Integrin signaling. The drug cyclophosphamide has been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and skin, and related mouse phenotypes are liver/biliary system and cardiovascular system.
Disease Ontology:11 An autoimmune disease that is located in lung, located in kidney, located in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.
Genetics Home Reference:24 Granulomatosis with polyangiitis (GPA) is a condition that causes inflammation that primarily affects the respiratory tract (including the lungs and airways) and the kidneys. This disorder is also commonly known as Wegener granulomatosis. A characteristic feature of GPA is inflammation of blood vessels (vasculitis), particularly the small- and medium-sized blood vessels in the lungs, nose, sinuses, windpipe, and kidneys, although vessels in any organ can be involved. Polyangiitis refers to the inflammation of multiple types of vessels, such as small arteries and veins. Vasculitis causes scarring and tissue death in the vessels and impedes blood flow to tissues and organs.
NIH Rare Diseases:46 Granulomatosis with polyangiitis (wegener's) is a type of vasculitis, or inflammation of the blood vessels. this limits the flow of blood to important organs, causing damage. it can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs and kidneys. symptoms can vary in nature and severity, and may include sinus pain; discolored or bloody fluid from the nose; nasal ulcers; constant runny nose (rhinorrhea); joint pain; weakness; tiredness; and/or skin lesions. the cause of granulomatosis with polyangiitis is unknown. early treatment is important. most people improve with medicines to slow or stop the inflammation. last updated: 5/25/2015
OMIM:50 Wegener granulomatosis (WG) is a systemic disease with a complex genetic background. It is characterized by necrotizing... (608710) more...
Wikipedia:69 Granulomatosis with polyangiitis (GPA), previously known as Wegener\'s granulomatosis (WG), is a... more...
HPO human phenotypes related to Wegener Granulomatosis:(show all 57)
UMLS symptoms related to Wegener Granulomatosis:chest pain, coughing, snoring, vasculitic rash
Drugs for Wegener Granulomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 42)
Interventional clinical trials:(show top 50) (show all 106)
Search NIH Clinical Center for Wegener Granulomatosis
Inferred drug relations via UMLS66/NDF-RT44:
MalaCards organs/tissues related to Wegener Granulomatosis:34
Lung, Kidney, Skin, Trachea, Neutrophil, Monocytes, Testes
FMA organs/tissues related to Wegener Granulomatosis:17
Lung, Kidney, Skin
MGI Mouse Phenotypes related to Wegener Granulomatosis:39
Articles related to Wegener Granulomatosis:(show top 50) (show all 55)
Search GEO for disease gene expression data for Wegener Granulomatosis.
Pathways related to Wegener Granulomatosis according to GeneCards Suite gene sharing:(show all 23)
Cellular components related to Wegener Granulomatosis according to GeneCards Suite gene sharing:
Biological processes related to Wegener Granulomatosis according to GeneCards Suite gene sharing:(show all 26)
Molecular functions related to Wegener Granulomatosis according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet