GPA
MCID: WGN002
MIFTS: 67

Wegener's Granulomatosis (GPA) malady

Neuronal, Nephrological, Respiratory, Bone categories

Summaries for Wegener's Granulomatosis

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
See all sources

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Disease Ontology:8 An autoimmune disease that is a vasculitis that is located in lung, located in kidney, located in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

MalaCards: Wegener's Granulomatosis, also known as wegener granulomatosis, is related to vasculitis and systemic lupus erythematosus, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, seizures/epilepsy/absences/spasms/status epilepticus and hemiplegia/diplegia/hemiparesia/limb palsy. An important gene associated with Wegener's Granulomatosis is WG (Wegener granulomatosis), and among its related pathways are CD28 co-stimulation and Immune System. The drug cyclophosphamide and the compounds heparin and serine have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lung, and related mouse phenotypes are immune system and mortality/aging.

Description from OMIM:47 608710

Aliases & Classifications for Wegener's Granulomatosis

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 49Orphanet, 61UMLS, 10DISEASES, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
wegener granulomatosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

wegener's granulomatosis 8
wegener granulomatosis 9 47 49 61
wegeners granulomatosis 10 45
necrotizing respiratory granulomatosis 8
granulomatosis with polyangiitis 49
granulomatosis - wegener's 8
wegener's syndrome 8
gpa 49


External Ids:

Disease Ontology8 DOID:12132
MeSH35 D014890
OMIM47 608710
NCIt40 C3444
ICD9CM27 446.4
MESH via Orphanet36 D014890
ICD10 via Orphanet26 M31.3
SNOMED-CT via Orphanet58 195353004, 239934006
UMLS via Orphanet62 C0043092
ICD1025 M31.3

Related Diseases for Wegener's Granulomatosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Wegener's Granulomatosis family:

wegener-like granulomatosis

Diseases related to Wegener's Granulomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.5BPI, CTLA4, CTSG, MPO, PRTN3, CD14
2systemic lupus erythematosus30.3HLA-DPB1, MPO, PRTN3, CD86, CD80, CD28
3ulcerative colitis30.3CTSG, PRTN3, BPI
4tuberculosis30.3BPI, CTSG, CD86, EEA1, SERPINA1
5arthritis30.1CCR5, CTLA4, CTSG, MPO, PRTN3, CD86
6mononeuritis multiplex30.1MPO, PRTN3
7rapidly progressive glomerulonephritis30.1MPO, PRTN3
8orbital granuloma10.4
9polyarteritis nodosa10.4
10microscopic polyangiitis10.4
11takayasu's arteritis10.3
12churg-strauss syndrome10.3
13micro syndrome10.3
14granulomatosis with polyangiitis10.3
15cytomegalovirus infection10.3
16eosinophilic granulomatosis with polyangiitis10.3
17n syndrome10.3
18bronchiolitis obliterans organizing pneumonia10.2
19bronchiolitis obliterans10.2
20bronchiolitis10.2
21sciatic neuropathy10.2
22idiopathic pulmonary fibrosis10.2
23coronary aneurysm10.2
24hydronephrosis10.2
25ischemic neuropathy10.2
26sialadenitis10.2
27subacute bacterial endocarditis10.2
28ischemic optic neuropathy10.2
29acne10.2
30aortic aneurysm10.2
31sleep disorder10.2
32allergic angiitis10.2
33coronary artery aneurysm10.2
34hypereosinophilic syndrome10.2
35kikuchi disease10.2
36thromboembolism10.2
37hemorrhage, intracerebral10.2
38fibromyalgia10.2
39crescentic glomerulonephritis10.1
40choroiditis10.1
41granulomatous myositis10.1
42mucocutaneous leishmaniasis10.1
43good syndrome10.1
44panhypopituitarism10.1
45goodpasture syndrome10.1
46cicatricial pemphigoid10.1
47pyoderma gangrenosum10.1
48encephalocele10.1
49ocular cicatricial pemphigoid10.1
50tracheoesophageal fistula10.1

Graphical network of the top 20 diseases related to Wegener's Granulomatosis:



Diseases related to wegener's granulomatosis

Clinical Features for Wegener's Granulomatosis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

608710

Symptoms:

49 (show all 66)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • seizures/epilepsy/absences/spasms/status epilepticus
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • chronic arterial hypertension
  • chronic/relapsing otitis
  • repeat respiratory infections
  • sensorineural deafness/hearing loss
  • visual loss/blindness/amblyopia
  • proteinuria
  • diabetes insipidus
  • asthenia/fatigue/weakness
  • retinopathy
  • renal failure
  • cranial nerves palsy
  • fever/chilling
  • articular/joint pain/arthralgia
  • lung fibrosis
  • cardiac rhythm disorder/arrhythmia
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • follicular/erythematous/edematous papules/milium
  • peripheral neuropathy
  • sensitive trouble/deficit
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • thoracic/chest pain
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • gangrena/necrosis
  • myalgia/muscular pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • angor pectoris/myocardial infarction
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • lung/pulmonary infiltrates
  • hematuria/microhematuria
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • venous thrombosis/phlebitis/thrombophlebitis
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • pancreatitis
  • purpura/petichiae
  • intestinal obstruction/ileus
  • renal glomerular defect/glomerulopathy
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • chronic obstructive pulmonary disease/copd/obstructive respiratory syndrome
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • epistaxis/nose bleeding
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • vascularitis/vasculitides/arteritis
  • meningitis/meningeal syndrome
  • palpebral edema/periorbital edema
  • proptosis/exophthalmos
  • hemoptysis
  • anomalies of nose and olfaction
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • enanthema/aphtosa/aphta/leukoplakia
  • prostatic inflammation/prostatitis
  • intestinal perforation
  • neuritis/polyneuritis/multineuritis
  • ureteral stenosis/narrowing

Drugs & Therapeutics for Wegener's Granulomatosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Wegener's Granulomatosis

Drug clinical trials:

Search ClinicalTrials for Wegener's Granulomatosis

Search NIH Clinical Center for Wegener's Granulomatosis

Search CenterWatch for Wegener's Granulomatosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Wegener's Granulomatosis

Anatomical Context for Wegener's Granulomatosis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Wegener's Granulomatosis:

33
Skin, Spinal cord, Brain, Kidney, Lung, Heart, Small intestine, Salivary gland, Prostate, T cells, B cells, Endothelial, Pituitary

FMA organs/tissues related to Wegener's Granulomatosis:

14
Skin, Kidney, Lung

Animal Models for Wegener's Granulomatosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Wegener's Granulomatosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6ELANE, CCR5, CTLA4, CTSG, MPO, PRTN3
2MP:001076810.6CTLA4, CTSG, MPO, CD14, PTPN22, SELE
3MP:000539710.5CD86, MPO, CTSG, CTLA4, CCR5, CD80
4MP:000537610.3CD14, CD86, MPO, CTLA4, CCR5, CD28

Publications for Wegener's Granulomatosis

Sources:
51PubMed
See all sources

Articles related to Wegener's Granulomatosis:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Clinical images: Bronchial stenosis in granulomatosis with polyangiitis (Wegener's). (23983058)
2013
2
Low dose radiotherapy as an effective treatment in a patient with solitary Wegener's granulomatosis resistant to systemic treatment - case report. (23788974)
2013
3
Parotitis as the presenting symptom of Wegener's granulomatosis: case report and meta-analysis. (23662387)
2013
4
Magnetic resonance imaging in patients with granulomatosis with polyangiitis (Wegener's) and subglottic stenosis. (23086288)
2013
5
The clinicopathologic characteristics of granulomatosis with polyangiitis (Wegener's): a retrospective study of 45 patients in Korea. (22983617)
2013
6
New treatment of subglottic stenosis due to Wegener's granulomatosis. (22668235)
2012
7
Malignant Wegener's granulomatosis with fibrosing mediastinitis and vena cava superior syndrome. (22260549)
2012
8
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. (22508400)
2012
9
Bilateral scleromalacia perforans and peripheral corneal thinning in Wegener's granulomatosis. (22553696)
2011
10
Subglottic stenosis is a form of limited Wegener's granulomatosis. (21965697)
2011
11
Airway reconstruction in Wegener's granulomatosis-associated laryngotracheal stenosis. (22109754)
2011
12
Strawberry gingivitis as the first presenting sign of Wegener's granulomatosis: report of a case. (21813375)
2011
13
Early extracorporeal life support as rescue for Wegener granulomatosis with diffuse alveolar hemorrhage and acute respiratory distress syndrome: a case report and literature review. (22158275)
2011
14
Surgical interventions and local therapy for Wegener's granulomatosis. (19910793)
2010
15
Successful treatment of hypertrophic pachymeningitis in refractory Wegener's granulomatosis with rituximab. (19802640)
2010
16
Skin ulcer presentation of Wegener's granulomatosis. (22797199)
2010
17
Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial. (20643762)
2010
18
Focal segmental glomerulosclerosis as the sole renal lesion in Wegener's granulomatosis. (21060184)
2010
19
A case of primary SjAPgren's syndrome with pulmonary-limited Wegener's granulomatosis. (19578851)
2010
20
A case report of limited Wegener's granulomatosis presenting with a chronic scalp ulcer. (21280536)
2010
21
Prospective long-term follow-up of patients with localised Wegener's granulomatosis: does it occur as persistent disease stage? (20511614)
2010
22
EULAR/PRINTO/PRES criteria for Henoch-SchAPnlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation. (20388738)
2010
23
Effectiveness of rituximab in severe Wegener's granulomatosis: report of two cases and review of the literature. (19590594)
2009
24
Wegener's granulomatosis patients show an adequate antibody response to influenza vaccination. (18625625)
2009
25
Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis. (18594952)
2009
26
High frequency of venous thromboembolic events in Churg-Strauss syndrome, Wegener's granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients. (19015208)
2009
27
Successful endonasal dacryocystorhinostomy in a patient with Wegener's granulomatosis. (20054412)
2009
28
Wegener's granulomatosis in which rheumatoid factor was useful for evaluating the disease status: a case report. (19829787)
2009
29
Can sulfasalazine therapy induce or exacerbate Wegener's granulomatosis? (18189198)
2008
30
Spontaneous pneumothorax in Wegener's granulomatosis: a case report. (18161001)
2008
31
Assessment of the item selection and weighting in the Birmingham vasculitis activity score for Wegener's granulomatosis. (18512722)
2008
32
Superior oblique myositis as an early feature of orbital Wegener's granulomatosis. (18569830)
2008
33
Clinical images: perforation of the nasal septum and palate due to Wegener's granulomatosis. (18668555)
2008
34
Spontaneous remission in Wegener's granulomatosis. (17763213)
2007
35
The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis. (17693606)
2007
36
Episcleris, arthrofasciitis and hypereosinophilia: primary hypereosinophilic syndrome or atypical Wegener's granulomatosis? (17589852)
2007
37
Can methotrexate replace cyclophosphamide in the treatment of a subset of Wegener's granulomatosis and microscopic polyangiitis? (16932658)
2006
38
Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. (15708894)
2005
39
Analysis of autoantibody repertoires in small- and medium-sized vessels vasculitides. Evidence for specific perturbations in polyarteritis nodosa, microscopic polyangiitis, Churg-Strauss syndrome and Wegener's granulomatosis. (15829409)
2005
40
Peripheral blood and granuloma CD4(+)CD28(-) T cells are a major source of interferon-gamma and tumor necrosis factor-alpha in Wegener's granulomatosis. (12000723)
2002
41
Correspondence re: Gal AA, Velasquez A. Antineutrophil cytoplasmic autoantibody in the absence of Wegener's granulomatosis or microscopic polyangiitis: implications for the surgical pathologist. Mod Pathol 2002;15:197-204. (12429804)
2002
42
Antineutrophil cytoplasmic autoantibody in the absence of Wegener's granulomatosis or microscopic polyangiitis: implications for the surgical pathologist. (11904336)
2002
43
Lack of evidence for an association between hantavirus infections and Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and giant cell arteritis. (11136889)
2000
44
Clinical images: orbital granuloma and subglottic tracheal stenosis in Wegener's granulomatosis. (10902772)
2000
45
Splenic infarction in a patient with Wegener's granulomatosis. (10556277)
1999
46
New developments in the treatment of Wegener's granulomatosis, polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. (9110130)
1997
47
Expression of the human autoantigen of Wegener's granulomatosis (PR3) in a baculovirus expression system. (8604978)
1996
48
Penile granulomas with urethral stricture: unusual presentation of Wegener's granulomatosis. (7742190)
1995
49
The phylogeny of proteinase 3/myeloblastin, the autoantigen in Wegener's granulomatosis, and myeloperoxidase as shown by immunohistochemical studies on human leukemic cell lines. (8261669)
1994
50
Small intestinal perforation in Wegener's granulomatosis. (2746597)
1989

Genetic Variations for Wegener's Granulomatosis

Expression for genes affiliated with Wegener's Granulomatosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Wegener's Granulomatosis

Search GEO for disease gene expression data for Wegener's Granulomatosis.

Pathways for genes affiliated with Wegener's Granulomatosis

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PTPN22, CTLA4, HLA-DPB1, CD86, CD80, CD28
2
Hide members
10.5CTLA4, HLA-DPB1, CD86, CD14, CD80, CD28
310.5CTLA4, HLA-DPB1, CD86, CD80, CD28
4
Hide members
10.5CD28, CD80, CD86, HLA-DPB1, CTLA4
5
Hide members
10.5CTSG, HLA-DPB1, CD86, CD80, CD28
610.5HLA-DPB1, MPO, CD14, EEA1
710.5MPO, CD86, CD14, ELANE
810.5ELANE, PRTN3, MPO
9
Hide members
10.5CTLA4, CD86, CD80, CD28
10
Hide members
10.5CD28, CD80, CD86, CTLA4
11
Immune response NFAT in immune response
Hide members
10.5HLA-DPB1, CD86, CD80, CD28
12
Immune response ICOS pathway in T-helper cell
Hide members
10.5CD28, CD80, CD86, HLA-DPB1
13
Hide members
10.5CD80, CD86, CTLA4
1410.5SELE, CD80, HLA-DPB1
1510.5HLA-DPB1, CD86, CD28
16
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.5ELN, ELANE, SELE
1710.5SERPINB1, CD14, CTSG
1810.5CD86, CD80, CD28
1910.5CD86, CD80, CD28
2010.5CD86, CD80, CD28
21
Hide members
10.5CD28, CD80, CD86
2210.5CD28, CD80, CD86
23
Hide members
10.5CD28, CD80, CD86
24
Hide members
10.5ELN, ELANE

Compounds for genes affiliated with Wegener's Granulomatosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1heparin45 29 11 2414.0ELN, BPI, CCR5, CTSG, MPO, CD14
2serine4511.0CCR5, CTLA4, CTSG, MPO, PRTN3, SELE
3histamine45 29 2413.0CCR5, CTSG, MPO, CD86, CD14, SELE
4cysteine4511.0BPI, CCR5, CTLA4, CTSG, CD14, CD28
5alanine4511.0BPI, CCR5, CTLA4, CTSG, PRTN3, CD14
6creatinine4511.0BPI, CTSG, MPO, CD14, SERPINA1, SELE
7cyclosporin a45 29 6013.0CCR5, CTLA4, CD86, CD14, CD80, CD28
8polysaccharide4511.0BPI, CCR5, CTSG, CD14, SERPINA1, SELE
9diisopropylfluorophosphate4511.0CTSG, PRTN3, SERPINA1, ELANE, ELN
10lipid4511.0BPI, CTLA4, CTSG, PRTN3, CD14, CD28
11fmlp4511.0BPI, CTSG, MPO, PRTN3, CD14, ELANE
12lactate4511.0BPI, CTSG, MPO, CD14, SELE, ELANE
13ctla4-ig4511.0CTLA4, CD86, CD80, CD28
14endotoxin4511.0BPI, CTSG, CD86, SELE
15tyrosine4511.0CCR5, CTLA4, PRTN3, CD86, CD80, CD28
16hocl4510.9CTSG, MPO, SERPINA1, ELANE
17fibrinogen4510.9CTSG, CD14, SERPINA1, SELE, ELANE, ELN
18belatacept45 1111.9CTLA4, CD86, CD80
19abatacept45 1111.9CTLA4, CD86, CD80
20rapamycin4510.9CCR5, CTLA4, CD86, CD80, CD28, ELN
21saccharin45 211.9ELANE, PRTN3, CTSG
22desmosine4510.9SERPINA1, ELANE, ELN
23retinoic acid45 2411.9BPI, CCR5, CTSG, MPO, PRTN3, CD14
24cytochalasin b4510.9CTSG, MPO, PRTN3, ELANE
25carbohydrates4510.9CTSG, CD14, CD80, SELE, ELN
26cycloheximide4510.9ELN, CTSG
27wortmannin4510.9CTLA4, CD86, CD14, CD80, CD28, EEA1
28n-formylmethionyl-leucylphenylalanine4510.9CTSG, MPO, PRTN3, ELANE
29cholesterol45 29 11 2413.9BPI, CCR5, CTLA4, CD14, EEA1, SERPINA1
30xanthine45 2411.9CTSG, MPO, CD14, TPMT
31dextran sulfate4510.9ELANE, MPO, CCR5
32valine4510.8CCR5, ELANE, ELN
33allergens4510.8CD80, CD14, CD86, CTLA4
34(4-aminophenyl)mercuric acetate4510.8CTSG, ELANE, ELN
35polyacrylamide4510.8CCR5, CTLA4, CTSG, CD14, SERPINA1
36dexamethasone45 50 29 1113.8CTLA4, CD86, CD14, CD80
37thermolysin4510.8CTSG, ELANE, ELN
38nitric oxide45 11 2412.8BPI, CTSG, MPO, CD86, CD80, SERPINA1
39calcium45 50 11 2413.8CCR5, CTLA4, CTSG, MPO, PRTN3, CD14
40pmsf4510.8PRTN3, CTSG
41superoxide45 2411.8SERPINB1, ELANE
42hydralazine45 50 1112.7SERPINB1
43zymosan4510.7MPO, CD14, ELANE
44sodium dodecylsulfate4510.7CTSG, CD86, ELANE, ELN
454-nitroanilide4510.6CTSG, ELANE
461-hydroxyphenazine4510.6MPO, ELANE
47dextran4510.5CD80, CD86, CTSG
48elastatinal4510.5CTSG, ELANE
49isodesmosine4510.4ELANE, ELN
50methionine4510.2CCR5, CTLA4, CTSG, CD14, SERPINA1

GO Terms for genes affiliated with Wegener's Granulomatosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5SERPINB1, SELE, SERPINA1, CD14, MPO, CTSG
2external side of plasma membraneGO:00989710.5CD28, CD80, CD86, CTLA4, CCR5
3plasma membraneGO:00588610.5HLA-DPB1, CTSG, CTLA4, CCR5, PRTN3, CD86
4secretory granuleGO:03014110.2CTSG, MPO, ELANE

Biological processes related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129510.7CD28, CD80, CD86, HLA-DPB1, CTLA4
2positive regulation of interleukin-2 biosynthetic processGO:04508610.6CD86, CD80, CD28
3negative regulation of growth of symbiont in hostGO:04413010.6ELANE, MPO, CTSG
4response to lipopolysaccharideGO:03249610.6CTSG, SERPINA1, SELE, ELANE
5immune responseGO:00695510.5BPI, CCR5, CTLA4, CTSG, CD86
6positive regulation of alpha-beta T cell proliferationGO:04664110.5CD28, CD80
7response to yeastGO:00187810.4ELANE, MPO
8positive regulation of immune responseGO:05077810.2ELANE, CTSG

Molecular functions related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.5CD14, BPI
2coreceptor activityGO:01502610.4CD28, CD80, CD86, CCR5
3protease bindingGO:00202010.2ELANE, SERPINA1, CD28

Products for genes affiliated with Wegener's Granulomatosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Wegener's Granulomatosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet