GPA
MCID: WGN002
MIFTS: 75

Wegener's Granulomatosis (GPA) malady

Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases categories

Summaries for Wegener's Granulomatosis

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 An autoimmune disease that is a vasculitis that is located in lung, located in kidney, located in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

MalaCards: Wegener's Granulomatosis, also known as wegener granulomatosis, is related to vasculitis and systemic lupus erythematosus, and has symptoms including ureteral stenosis/narrowing, megaureter/hydronephrosis/pyeloureteral junction syndrome and renal failure. An important gene associated with Wegener's Granulomatosis is WG (Wegener granulomatosis), and among its related pathways are CD28 co-stimulation and Immune System. The drug cyclophosphamide and the compounds heparin and serine have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lung, and related mouse phenotypes are immune system and mortality/aging.

Description from OMIM:46 608710

Aliases & Classifications for Wegener's Granulomatosis

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 48Orphanet, 60UMLS, 10DISEASES, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
wegener granulomatosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

wegener's granulomatosis 8
wegener granulomatosis 9 46 48 60
wegeners granulomatosis 10 44
necrotizing respiratory granulomatosis 8
granulomatosis with polyangiitis 48
granulomatosis - wegener's 8
wegener's syndrome 8
gpa 48


External Ids:

Disease Ontology8 DOID:12132
MeSH34 D014890
OMIM46 608710
NCIt39 C3444
ICD9CM27 446.4
MESH via Orphanet35 D014890
ICD10 via Orphanet26 M31.3
SNOMED-CT via Orphanet57 195353004, 239934006
UMLS via Orphanet61 C0043092
ICD1025 M31.3

Related Diseases for Wegener's Granulomatosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Wegener's Granulomatosis family:

Wegener-Like Granulomatosis

Diseases related to Wegener's Granulomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.4BPI, CTLA4, CTSG, MPO, PRTN3, CD14
2systemic lupus erythematosus30.2HLA-DPB1, MPO, PRTN3, CD86, CD80, CD28
3ulcerative colitis30.2CTSG, PRTN3, BPI
4tuberculosis30.2BPI, CTSG, CD86, EEA1, SERPINA1
5pneumonia30.2BPI, CTSG, MPO, SERPINA1, SERPINB1, ELANE
6pulmonary fibrosis30.2MPO, ELANE, ELN
7endocarditis30.2PRTN3
8rheumatoid arthritis30.1CD86, CD14, CD80, CD28, PTPN22, SERPINA1
9arthritis30.1CCR5, CTLA4, CTSG, MPO, PRTN3, CD86
10gingivitis30.1ELANE, CTSG
11mononeuritis multiplex30.1MPO, PRTN3
12rapidly progressive glomerulonephritis30.1MPO, PRTN3
13thyroiditis30.0PTPN22, CTLA4
14neuropathy10.6
15polyarteritis nodosa10.4
16eosinophilic granulomatosis with polyangiitis10.3
17churg-strauss syndrome10.3
18purpura10.3
19granulomatosis with polyangiitis10.3
20bronchiolitis obliterans organizing pneumonia10.2
21bronchiolitis obliterans10.2
22bronchiolitis10.2
23sciatic neuropathy10.2
24idiopathic pulmonary fibrosis10.2
25coronary aneurysm10.2
26hydronephrosis10.2
27ischemic neuropathy10.2
28sialadenitis10.2
29subacute bacterial endocarditis10.2
30ischemic optic neuropathy10.2
31aortic aneurysm10.2
32intestinal perforation10.2
33lung cancer10.2
34lupus erythematosus10.2
35periostitis10.2
36peripheral neuropathy10.2
37ruptured aortic aneurysm10.2
38sleep disorder10.2
39t cell deficiency10.2
40allergic angiitis10.2
41crescentic glomerulonephritis10.1
42choroiditis10.1
43granulomatous myositis10.1
44mucocutaneous leishmaniasis10.1
45panhypopituitarism10.1
46goodpasture syndrome10.1
47cicatricial pemphigoid10.1
48pyoderma gangrenosum10.1
49blue toe syndrome10.1
50chronic conjunctivitis10.1

Graphical network of the top 20 diseases related to Wegener's Granulomatosis:



Diseases related to wegener's granulomatosis

Clinical Features for Wegener's Granulomatosis

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

608710

Symptoms:

48 (show all 66)
  • ureteral stenosis/narrowing
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • renal failure
  • autoimmunity/autoimmune reaction/autoantibodies
  • gangrena/necrosis
  • venous thrombosis/phlebitis/thrombophlebitis
  • chronic arterial hypertension
  • angor pectoris/myocardial infarction
  • cardiac rhythm disorder/arrhythmia
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • prostatic inflammation/prostatitis
  • diabetes insipidus
  • cranial nerves palsy
  • myalgia/muscular pain
  • sensitive trouble/deficit
  • seizures/epilepsy/absences/spasms/status epilepticus
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • meningitis/meningeal syndrome
  • facial pain/cephalalgia/migraine
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • anomalies of nose and olfaction
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • palpebral edema/periorbital edema
  • cutaneous rash
  • follicular/erythematous/edematous papules/milium
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • epistaxis/nose bleeding
  • articular/joint pain/arthralgia
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • enanthema/aphtosa/aphta/leukoplakia
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • repeat respiratory infections
  • vascularitis/vasculitides/arteritis
  • renal glomerular defect/glomerulopathy
  • hematuria/microhematuria
  • transient cerebral ischemia/stroke
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • lung/pulmonary infiltrates
  • lung fibrosis
  • thoracic/chest pain
  • retinopathy
  • visual loss/blindness/amblyopia
  • sensorineural deafness/hearing loss
  • chronic/relapsing otitis
  • chronic skin infection/ulcerations/ulcers/cancrum
  • purpura/petichiae
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal obstruction/ileus
  • intestinal perforation
  • proptosis/exophthalmos
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • chronic obstructive pulmonary disease/copd/obstructive respiratory syndrome
  • proteinuria
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • peripheral neuropathy
  • neuritis/polyneuritis/multineuritis
  • pancreatitis

Drugs & Therapeutics for Wegener's Granulomatosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Wegener's Granulomatosis

Drug clinical trials:

Search ClinicalTrials for Wegener's Granulomatosis

Search NIH Clinical Center for Wegener's Granulomatosis

Search CenterWatch for Wegener's Granulomatosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Wegener's Granulomatosis

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Anatomical Context for Wegener's Granulomatosis

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Wegener's Granulomatosis:

32
Lung, Skin, Kidney, T cells, Prostate, Endothelial, Pituitary, Bone, B cells, Hypothalamus, Thyroid, Testes, Colon, Heart, Salivary gland, Small intestine, Breast, Eye, Occipital lobe, Monocytes, Spinal cord, Brain, Tongue

FMA organs/tissues related to Wegener's Granulomatosis:

14
Skin, Kidney, Lung

Animal Models for Wegener's Granulomatosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Wegener's Granulomatosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6ELANE, CCR5, CTLA4, CTSG, MPO, PRTN3
2MP:001076810.6CTLA4, CTSG, MPO, CD14, PTPN22, SELE
3MP:000539710.5CD86, MPO, CTSG, CTLA4, CCR5, CD80
4MP:000537610.3CD14, CD86, MPO, CTLA4, CCR5, CD28

Publications for Wegener's Granulomatosis

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Sources:
50PubMed
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Articles related to Wegener's Granulomatosis:

(show top 50)    (show all 827)
idTitleAuthorsYear
1
Subglottic and tracheal stenosis due to Wegener's granulomatosis. (22826070)
2013
2
Widespread cranial nerve palsies while on cyclophosphamide therapy: a very rare manifestation of Wegener's granulomatosis (granulomatosis with polyangitis). (24142466)
2013
3
Hypophyseal Wegener's granulomatosis presenting by visual field constriction without hypopituitarism. (22898089)
2013
4
Wegener's granulomatosis causing bilateral facial paralysis and deafness. (22197457)
2013
5
Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. (22021864)
2012
6
Cytomegalovirus retinitis treated with valganciclovir in Wegener's granulomatosis. (22536046)
2012
7
Molecular signatures of a disturbed nasal barrier function in the primary tissue of Wegener's granulomatosis. (21412229)
2011
8
Isolated bladder vasculitis: a rare presentation of Wegener's granulomatosis. (21322469)
2011
9
Wegener's granulomatosis: a rare cause of hydronephrosis. (21577265)
2011
10
Strawberry gingivitis as the first presenting sign of Wegener's granulomatosis: report of a case. (21813375)
2011
11
Cyclophosphamide as induction therapy for Wegener's granulomatosis and microscopic polyangiitis. (21447129)
2011
12
Acute pancreatitis as a rare initial manifestation of Wegener's granulomatosis. A case based review of literature. (21386646)
2011
13
Fluorine-18-fluorodeoxyglucose PET/CT rare finding of a unique multiorgan involvement of Wegener's granulomatosis. (21933977)
2011
14
Wegener's granulomatosis of the paranasal sinuses with orbital and central nervous system involvement-diagnostic imaging. (22141293)
2011
15
B cell abnormalities in Wegener's granulomatosis and microscopic polyangiitis: role of CD25+-expressing B cells. (20716663)
2010
16
Wegener's granulomatosis presenting with life-threatening lung hemorrhage in a 7-year-old child. (19777238)
2010
17
Mixed lymphohematopoietic chimerism and response in Wegener's granulomatosis. (20573937)
2010
18
Symmetrical nail bed uptake on a (99m)Tc-HDP bone scan in a patient with Wegener's granulomatosis. (19997912)
2010
19
Predictors at diagnosis of a first Wegener's granulomatosis relapse after obtaining complete remission. (20675708)
2010
20
Clinical characteristics and long-term outcomes of 35 patients with Wegener's granulomatosis followed up at two rheumatology centers in Lithuania. (20571293)
2010
21
Increased risk of autoimmune disease in families with Wegener's granulomatosis. (20889595)
2010
22
Expression of CD57 on CD8+ T lymphocytes of patients with Wegener's granulomatosis and microscopic polyangiitis: evidence for continuous activation of CD8+ cells. (19646341)
2009
23
PR3-ANCA in Wegener's granulomatosis prime human mononuclear cells for enhanced activation via TLRs and NOD1/2. (19594951)
2009
24
T-lymphocytes and disease mechanisms in Wegener's granulomatosis. (19907189)
2009
25
Cardiac disease causing death in a child with Wegener's granulomatosis. (19903254)
2009
26
Wegener's granulomatosis: epidemiological and clinical features in a South Australian study. (19143878)
2008
27
Fatal course of Wegener's granulomatosis with bilateral otomastoiditis and bilateral facial nerve palsy. (18503861)
2008
28
The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping. (17967832)
2008
29
The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event. (17918782)
2007
30
Successful therapeutic use of rituximab in refractory Wegener's granulomatosis after renal transplantation. (18044265)
2007
31
Characterization of the expanded T-cell populations in patients with Wegener's granulomatosis. (16918819)
2006
32
Membrane proteinase 3 expression in patients with Wegener's granulomatosis and in human hematopoietic stem cell-derived neutrophils. (15901769)
2005
33
Horner's syndrome as manifestation of Wegener's granulomatosis. (14976543)
2004
34
Expression of matrix metalloproteinases in patients with Wegener's granulomatosis. (15547092)
2004
35
Photo quiz. Palisaded neutrophilic and granulomatous dermatitis with underlying Wegener's granulomatosis. (12184668)
2002
36
Serum level of macrophage migration inhibitory factor as a useful parameter of clinical course in patients with Wegener's granulomatosis and relapsing polychondritis. (11713914)
2001
37
Polymorphisms in CTLA-4 but not tumor necrosis factor-alpha or interleukin 1beta genes are associated with Wegener's granulomatosis. (10685804)
2000
38
Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis. (9734683)
1998
39
Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. (9355084)
1997
40
Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies. (8612734)
1996
41
Complexes between proteinase 3, alpha 1-antitrypsin and proteinase 3 anti-neutrophil cytoplasm autoantibodies: a comparison between alpha 1-antitrypsin PiZ allele carriers and non-carriers with Wegener's granulomatosis. (8889441)
1996
42
Exacerbation of Wegener's granulomatosis during pregnancy: report of a case with tracheal stenosis and literature review. (7932434)
1994
43
Wegener's granulomatosis associated with silicosis. (8090339)
1994
44
Case report: Wegener's granulomatosis accompanied by communicating hydrocephalus. (8160722)
1994
45
Circulating adhesion molecules ICAM-1, VCAM-1 and E-selectin in systemic vasculitis: marked differences between Wegener's granulomatosis and systemic lupus erythematosus. (7532481)
1994
46
Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity. (1458677)
1992
47
Distribution pattern of proteinase 3 in Wegener's granulomatosis and other vasculitic diseases]. (2060965)
1991
48
Severe granulomatous giant cell myocarditis in Wegener's granulomatosis. (2214615)
1990
49
Wegener's granulomatosis: report of a case with rapidly progressive glomerulonephritis and diabetes mellitus. (3593130)
1986
50
Wegener's granulomatosis and polymorphic reticulosis--two diseases or one? Experience with 90 patients. (7469900)
1981

Genetic Variations for Wegener's Granulomatosis

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Expression for genes affiliated with Wegener's Granulomatosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Wegener's Granulomatosis

Search GEO for disease gene expression data for Wegener's Granulomatosis.

Pathways for genes affiliated with Wegener's Granulomatosis

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
See all sources

Pathways related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PTPN22, CTLA4, HLA-DPB1, CD86, CD80, CD28
2
Hide members
10.5CTLA4, HLA-DPB1, CD86, CD14, CD80, CD28
310.5CTLA4, HLA-DPB1, CD86, CD80, CD28
4
Hide members
10.5CD28, CD80, CD86, HLA-DPB1, CTLA4
5
Hide members
10.5CTSG, HLA-DPB1, CD86, CD80, CD28
610.5HLA-DPB1, MPO, CD14, EEA1
710.5MPO, CD86, CD14, ELANE
810.5ELANE, PRTN3, MPO
9
Hide members
10.5CTLA4, CD86, CD80, CD28
10
Hide members
10.5CD28, CD80, CD86, CTLA4
11
Immune response NFAT in immune response
Hide members
10.5HLA-DPB1, CD86, CD80, CD28
12
Immune response ICOS pathway in T-helper cell
Hide members
10.5CD28, CD80, CD86, HLA-DPB1
13
Hide members
10.5CD80, CD86, CTLA4
1410.5SELE, CD80, HLA-DPB1
1510.5HLA-DPB1, CD86, CD28
16
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.5ELN, ELANE, SELE
1710.5SERPINB1, CD14, CTSG
1810.5CD86, CD80, CD28
1910.5CD86, CD80, CD28
2010.5CD86, CD80, CD28
21
Hide members
10.5CD28, CD80, CD86
2210.5CD28, CD80, CD86
23
Hide members
10.5CD28, CD80, CD86
24
Hide members
10.5ELN, ELANE

Compounds for genes affiliated with Wegener's Granulomatosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2414.0SERPINA1, ELANE, SELE, CD14, MPO, CTSG
2serine4411.0PRTN3, CCR5, SELE, CTLA4, CTSG, ELN
3histamine44 28 2413.0ELN, TPMT, CD14, CD86, MPO, CTSG
4cysteine4411.0ELANE, ELN, SERPINA1, EEA1, CD28, CTSG
5alanine4411.0SELE, TPMT, BPI, CCR5, CTLA4, CTSG
6creatinine4411.0BPI, MPO, CD14, SERPINA1, SELE, TPMT
7cyclosporin a44 28 5913.0CD86, CD14, CD80, CD28, CTLA4, TPMT
8polysaccharide4411.0CCR5, CTSG, CD14, SERPINA1, SELE, ELN
9diisopropylfluorophosphate4411.0ELANE, CTSG, PRTN3, SERPINA1, ELN
10lipid4411.0CTSG, CD14, BPI, CTLA4, PRTN3, CD28
11fmlp4411.0ELANE, CD14, BPI, MPO, CTSG, PRTN3
12lactate4411.0ELN, ELANE, SELE, CTSG, MPO, BPI
13ctla4-ig4411.0CTLA4, CD28, CD80, CD86
14endotoxin4411.0CTSG, CD86, SELE, BPI
15tyrosine4411.0CD28, CD80, EEA1, CD86, CTLA4, CCR5
16hocl4410.9CTSG, MPO, SERPINA1, ELANE
17fibrinogen4410.9SERPINA1, SELE, ELN, ELANE, CTSG, CD14
18belatacept44 1111.9CD86, CTLA4, CD80
19abatacept44 1111.9CTLA4, CD86, CD80
20rapamycin4410.9CD80, CD86, CTLA4, ELN, CCR5, CD28
21saccharin44 211.9ELANE, CTSG, PRTN3
22desmosine4410.9ELANE, ELN, SERPINA1
23retinoic acid44 2411.9BPI, CCR5, ELANE, MPO, CD14, PRTN3
24cytochalasin b4410.9CTSG, ELANE, PRTN3, MPO
25carbohydrates4410.9CTSG, CD14, CD80, ELN, SELE
26cycloheximide4410.9CTSG, ELN
27wortmannin4410.9CD80, EEA1, CD28, CD86, CD14, CTLA4
28n-formylmethionyl-leucylphenylalanine4410.9ELANE, CTSG, PRTN3, MPO
29cholesterol44 28 11 2413.9CCR5, SERPINA1, CTLA4, BPI, CD14, EEA1
30xanthine44 2411.9MPO, CD14, TPMT, CTSG
31dextran sulfate4410.9CCR5, MPO, ELANE
32valine4410.8ELANE, CCR5, ELN
33allergens4410.8CD80, CTLA4, CD86, CD14
34(4-aminophenyl)mercuric acetate4410.8CTSG, ELN, ELANE
35polyacrylamide4410.8CTLA4, CCR5, CTSG, SERPINA1, CD14
36dexamethasone44 49 28 1113.8CD14, CD86, CD80, CTLA4
37thermolysin4410.8ELN, ELANE, CTSG
38nitric oxide44 11 2412.8CD80, MPO, CTSG, BPI, SERPINA1, CD86
39calcium44 49 11 2413.8MPO, PRTN3, CD14, CD80, CD28, SERPINB1
40pmsf4410.8CTSG, PRTN3
41superoxide44 2411.8SERPINB1, ELANE
42hydralazine44 49 1112.7SERPINB1
43zymosan4410.7MPO, CD14, ELANE
44sodium dodecylsulfate4410.7CD86, CTSG, ELN, ELANE
454-nitroanilide4410.6ELANE, CTSG
46elastatinal4410.6ELANE, CTSG
47dextran4410.5CD86, CD80, CTSG
48isodesmosine4410.5ELN, ELANE
491-hydroxyphenazine4410.4ELANE, MPO
50methionine4410.2CTSG, CCR5, CD14, SERPINA1, CTLA4

GO Terms for genes affiliated with Wegener's Granulomatosis

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Sources:
16Gene Ontology
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Cellular components related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5SERPINB1, SELE, SERPINA1, CD14, MPO, CTSG
2external side of plasma membraneGO:00989710.5CD28, CD80, CD86, CTLA4, CCR5
3plasma membraneGO:00588610.5HLA-DPB1, CTSG, CTLA4, CCR5, PRTN3, CD86
4secretory granuleGO:03014110.2CTSG, MPO, ELANE

Biological processes related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129510.7CD28, CD80, CD86, HLA-DPB1, CTLA4
2positive regulation of interleukin-2 biosynthetic processGO:04508610.6CD86, CD80, CD28
3negative regulation of growth of symbiont in hostGO:04413010.6ELANE, MPO, CTSG
4response to lipopolysaccharideGO:03249610.6CTSG, SERPINA1, SELE, ELANE
5immune responseGO:00695510.5BPI, CCR5, CTLA4, CTSG, CD86
6positive regulation of alpha-beta T cell proliferationGO:04664110.5CD28, CD80
7response to yeastGO:00187810.4ELANE, MPO
8positive regulation of immune responseGO:05077810.2ELANE, CTSG

Molecular functions related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.5CD14, BPI
2coreceptor activityGO:01502610.4CD28, CD80, CD86, CCR5
3protease bindingGO:00202010.2ELANE, SERPINA1, CD28

Products for genes affiliated with Wegener's Granulomatosis

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  • Antibodies
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Sources for Wegener's Granulomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet