GPA
MCID: WGN002
MIFTS: 74

Wegener's Granulomatosis (GPA) malady

Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases, Immune diseases, Skin diseases categories
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Summaries for Wegener's Granulomatosis

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Disease Ontology:8 An autoimmune disease that is a vasculitis that is located in lung, located in kidney, located in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

MalaCards based summary: Wegener's Granulomatosis, also known as wegener granulomatosis, is related to churg-strauss syndrome and polyarteritis nodosa, and has symptoms including anomalies of nose and olfaction, nasal congestion/sinusitis/rhinitis/rhinorrhea and enanthema/aphtosa/aphta/leukoplakia. An important gene associated with Wegener's Granulomatosis is WG (Wegener granulomatosis), and among its related pathways are CD28 co-stimulation and Immune response NFAT in immune response. The drug cyclophosphamide and the compounds propylthiouracil and gliclazide have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and skin, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:46 608710

Aliases & Classifications for Wegener's Granulomatosis

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Sources:
8Disease Ontology, 62UMLS, 9diseasecard, 46OMIM, 48Orphanet, 10DISEASES, 44Novoseek, 57SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Wegener's Granulomatosis, Aliases & Descriptions:

Name: Wegener's Granulomatosis 8
Wegener Granulomatosis 8 9 46 48 62
Wegeners Granulomatosis 10 44 62
Granulomatosis with Polyangiitis 48 62
 
Granulomatosis - Wegener's 8 62
Gpa 48 62
Necrotizing Respiratory Granulomatosis 8
Wegener's Syndrome 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
wegener granulomatosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:12132
OMIM46 608710
NCIt39 C3444
ICD9CM27 446.4
MeSH34 D014890
MESH via Orphanet35 D014890
ICD10 via Orphanet26 M31.3
UMLS via Orphanet63 C0043092
ICD1025 M31.3

Related Diseases for Wegener's Granulomatosis

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Diseases in the Wegener's Granulomatosis family:

Wegener-Like Granulomatosis

Diseases related to Wegener's Granulomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1churg-strauss syndrome31.2PRTN3, MPO
2polyarteritis nodosa31.2MPO, PRTN3
3rapidly progressive glomerulonephritis30.9MPO, PRTN3
4mononeuritis multiplex30.9MPO, PRTN3
5vasculitis30.8MPO, SELE, SULT1A3, PRTN3, CTLA4
6ulcerative colitis30.4TNFRSF4, MPO, SELE, PRTN3, CD28, CTLA4
7arthritis30.3MPO, SELE, SULT1A3, PRTN3, CXCL6, CTLA4
8asthma29.9TNFRSF4, MPO, SELE, PRTN3, CXCL6, MS4A2
9systemic lupus erythematosus29.9HLA-DPB1, TNFRSF4, MPO, SELE, SULT1A3, PRTN3
10rheumatoid arthritis29.2CTLA4, XCL1, CD28, IL18BP, CCR4, CXCL6
11eosinophilic granulomatosis with polyangiitis11.1
12granulomatosis with polyangiitis10.6
13neuropathy10.6
14pustulosis palmaris et plantaris10.5SELE
15hypersensitivity vasculitis10.5MPO, PRTN3
16mononeuropathy10.5PRTN3, MPO
17leukostasis10.4SELE, MPO
18peripheral vascular disease10.4SELE, MPO
19microscopic polyangiitis10.4
20allergic contact dermatitis10.4SELE, CCR4
21primary sclerosing cholangitis10.4PRTN3, MPO
22neutropenia10.4MPO, PRTN3, CD177
23emphysema due to aat deficiency10.4SERPINA2, PRTN3
24eosinophilia10.4MPO, PRTN3, CCR4
25bronchitis10.4MPO, PRTN3
26colitis10.4
27intestinal perforation10.4
28aneurysm10.4
29cytomegalovirus infection10.4
30thromboembolism10.4
31purpura10.4
32chronic obstructive pulmonary disease10.4MPO, PRTN3, CCR4
33nephritis10.3PRTN3, SULT1A3, MPO
34connective tissue disease10.3MPO, SELE, PRTN3, CTLA4
35paracoccidioidomycosis10.3CTLA4, CD28
36hypersensitivity reaction type ii disease10.3CTLA4, PRTN3, SELE, MPO
37chronic myeloid leukemia10.3CTLA4, CD177, PRTN3, MPO
38sinusitis10.3PRTN3, CXCL6
39nodular goiter10.3TNFRSF4, CD28, CTLA4
40uveitis10.3CTLA4, CCR4, TNFRSF18
41polymyositis10.3SELE, CD28, CTLA4
42dermatitis10.3SELE, MS4A2, CCR4, CTLA4
43adult respiratory distress syndrome10.3SELE, MPO
44allergic asthma10.3SELE, MS4A2, CCR4, CTLA4
45glomerulonephritis10.2MPO, PRTN3, CD28
46vascular disease10.2PRTN3, SULT1A3, SELE
47bronchiolitis obliterans10.2
48hepatitis10.2
49hypertension10.2
50idiopathic pulmonary fibrosis10.2

Graphical network of the top 20 diseases related to Wegener's Granulomatosis:



Diseases related to wegener's granulomatosis

Symptoms for Wegener's Granulomatosis

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Clinical features from OMIM:

608710

Symptoms:

48 (show all 66)
  • anomalies of nose and olfaction
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • enanthema/aphtosa/aphta/leukoplakia
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • repeat respiratory infections
  • vascularitis/vasculitides/arteritis
  • renal glomerular defect/glomerulopathy
  • hematuria/microhematuria
  • transient cerebral ischemia/stroke
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • articular/joint pain/arthralgia
  • autoimmunity/autoimmune reaction/autoantibodies
  • epistaxis/nose bleeding
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • palpebral edema/periorbital edema
  • cutaneous rash
  • follicular/erythematous/edematous papules/milium
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • lung/pulmonary infiltrates
  • lung fibrosis
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • chronic obstructive pulmonary disease/copd/obstructive respiratory syndrome
  • proteinuria
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • peripheral neuropathy
  • neuritis/polyneuritis/multineuritis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • proptosis/exophthalmos
  • retinopathy
  • visual loss/blindness/amblyopia
  • sensorineural deafness/hearing loss
  • chronic/relapsing otitis
  • chronic skin infection/ulcerations/ulcers/cancrum
  • purpura/petichiae
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal obstruction/ileus
  • intestinal perforation
  • pancreatitis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • chronic arterial hypertension
  • venous thrombosis/phlebitis/thrombophlebitis
  • gangrena/necrosis
  • ureteral stenosis/narrowing
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • renal failure
  • prostatic inflammation/prostatitis
  • diabetes insipidus
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • meningitis/meningeal syndrome
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • sensitive trouble/deficit
  • myalgia/muscular pain

HPO human phenotypes related to Wegener's Granulomatosis:

(show all 56)
id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 sinusitis hallmark (90%) HP:0000246
3 epistaxis hallmark (90%) HP:0000421
4 hematuria hallmark (90%) HP:0000790
5 weight loss hallmark (90%) HP:0001824
6 recurrent respiratory infections hallmark (90%) HP:0002205
7 vasculitis hallmark (90%) HP:0002633
8 cerebral ischemia hallmark (90%) HP:0002637
9 arthralgia hallmark (90%) HP:0002829
10 autoimmunity hallmark (90%) HP:0002960
11 paresthesia hallmark (90%) HP:0003401
12 abnormality of temperature regulation hallmark (90%) HP:0004370
13 glomerulopathy hallmark (90%) HP:0100820
14 proteinuria typical (50%) HP:0000093
15 abnormality of the hypothalamus-pituitary axis typical (50%) HP:0000864
16 skin rash typical (50%) HP:0000988
17 polyneuropathy typical (50%) HP:0001271
18 nausea and vomiting typical (50%) HP:0002017
19 abdominal pain typical (50%) HP:0002027
20 respiratory insufficiency typical (50%) HP:0002093
21 hemoptysis typical (50%) HP:0002105
22 pulmonary infiltrates typical (50%) HP:0002113
23 pulmonary embolism typical (50%) HP:0002204
24 pulmonary fibrosis typical (50%) HP:0002206
25 chronic obstructive pulmonary disease typical (50%) HP:0006510
26 inflammatory abnormality of the eye typical (50%) HP:0100533
27 periorbital edema typical (50%) HP:0100539
28 chest pain typical (50%) HP:0100749
29 prostatitis occasional (7.5%) HP:0000024
30 ureteral stenosis occasional (7.5%) HP:0000071
31 renal insufficiency occasional (7.5%) HP:0000083
32 otitis media occasional (7.5%) HP:0000388
33 sensorineural hearing impairment occasional (7.5%) HP:0000407
34 retinopathy occasional (7.5%) HP:0000488
35 visual impairment occasional (7.5%) HP:0000505
36 proptosis occasional (7.5%) HP:0000520
37 hypertension occasional (7.5%) HP:0000822
38 diabetes insipidus occasional (7.5%) HP:0000873
39 seizures occasional (7.5%) HP:0001250
40 meningitis occasional (7.5%) HP:0001287
41 coronary artery disease occasional (7.5%) HP:0001677
42 abnormality of the pericardium occasional (7.5%) HP:0001697
43 pancreatitis occasional (7.5%) HP:0001733
44 subcutaneous hemorrhage occasional (7.5%) HP:0001933
45 migraine occasional (7.5%) HP:0002076
46 restrictive lung disease occasional (7.5%) HP:0002091
47 abnormality of the pleura occasional (7.5%) HP:0002103
48 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
49 myalgia occasional (7.5%) HP:0003326
50 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
51 thrombophlebitis occasional (7.5%) HP:0004418
52 intestinal obstruction occasional (7.5%) HP:0005214
53 cranial nerve paralysis occasional (7.5%) HP:0006824
54 arrhythmia occasional (7.5%) HP:0011675
55 gangrene occasional (7.5%) HP:0100758
56 skin ulcer occasional (7.5%) HP:0200042

Drugs & Therapeutics for Wegener's Granulomatosis

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Drug clinical trials:

Search ClinicalTrials for Wegener's Granulomatosis

Search NIH Clinical Center for Wegener's Granulomatosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Wegener's Granulomatosis

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Anatomical Context for Wegener's Granulomatosis

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MalaCards organs/tissues related to Wegener's Granulomatosis:

32
Lung, Skin, Kidney, Neutrophil, T cells, Prostate, Endothelial, Bone, Pituitary, B cells, Hypothalamus, Thyroid, Heart, Colon, Salivary gland, Breast, Testes, Eye, Small intestine, Brain, Spinal cord, Tonsil, Monocytes, Occipital lobe, Tongue

FMA organs/tissues related to Wegener's Granulomatosis:

14
Lung, Kidney, Skin

Animal Models for Wegener's Granulomatosis or affiliated genes

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MGI Mouse Phenotypes related to Wegener's Granulomatosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1SELE, MPO, TNFSF9, TNFRSF18, PRTN3, CXCL6
2MP:00053976.8CTLA4, TNFRSF4, TNFRSF18, TNFSF9, MPO, SELE

Publications for Wegener's Granulomatosis

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Articles related to Wegener's Granulomatosis:

(show top 50)    (show all 791)
idTitleAuthorsYear
1
Treatment of orbital inflammation with rituximab in Wegener's granulomatosis. (22272561)
2012
2
Scleritis--Wegener's granulomatosis. (23256431)
2012
3
Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial. (20577017)
2011
4
Wegener's granulomatosis of the orbit: a review of clinical features and updates in diagnosis and treatment. (21958186)
2011
5
Clinical images: Reticular rash in a patient with Wegener's granulomatosis. (21360516)
2011
6
Outcomes of renal transplantation in recipients with Wegener's granulomatosis. (20394635)
2011
7
Wegener's granulomatosis with multiple pulmonary nodules - diagnostic difficulties. (21103126)
2010
8
Refractory otitis media as the first manifestation of Wegener's granulomatosis. (20835547)
2010
9
Chemosensory function in Wegener's granulomatosis: a preliminary report. (20043173)
2010
10
Survival of patients with Wegener's granulomatosis diagnosed in Finland in 1981-2000. (20132074)
2010
11
Pulmonary alveolar proteinosis in a 67-year-old woman with Wegener's granulomatosis. (20623200)
2010
12
Unexpectedly difficult intubation caused by subglottic stenosis in Wegener's granulomatosis. (20094734)
2010
13
Surgical interventions and local therapy for Wegener's granulomatosis. (19910793)
2010
14
Successful treatment of hypertrophic pachymeningitis in refractory Wegener's granulomatosis with rituximab. (19802640)
2010
15
Effectiveness of rituximab in severe Wegener's granulomatosis: report of two cases and review of the literature. (19590594)
2009
16
Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection. (19404959)
2009
17
Expression of CD57 on CD8+ T lymphocytes of patients with Wegener's granulomatosis and microscopic polyangiitis: evidence for continuous activation of CD8+ cells. (19646341)
2009
18
Cardiomyopathy associated with Wegener's granulomatosis. (21687156)
2009
19
Wegener's granulomatosis. (19266823)
2009
20
Wegener's granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease. (19175952)
2009
21
Wegener's granulomatosis patients show an adequate antibody response to influenza vaccination. (18625625)
2009
22
Subglottic stenosis as a complication of Wegener's granulomatosis. (18253680)
2008
23
Does the dose of methotrexate influence the rate of relapse in patients with Wegener's granulomatosis? (17998931)
2008
24
Balancing efficacy and cancer risk of cyclophosphamide for patients with Wegener's granulomatosis. (18506161)
2008
25
Can sulfasalazine therapy induce or exacerbate Wegener's granulomatosis? (18189198)
2008
26
The p53 G72C and MDM2 T309G single nucleotide polymorphisms in patients with Wegener's granulomatosis. (18799058)
2008
27
Acute interstitial nephritis complicating a new diagnosis of Wegener's granulomatosis. (18309834)
2008
28
Wegener's granulomatosis mimicking facial granulomatous rosacea: a separate subset? (17989900)
2007
29
Wegener's granulomatosis presenting with granulomatous facial erythematous papules and plaques mimicking granulomatous rosacea. (16792787)
2006
30
Microscopic polyangiitis or Wegener's granulomatosis? That is the question. (16548912)
2006
31
Wegener's granulomatosis presenting as diabetes insipidus. (17115352)
2006
32
Wegener's granulomatosis presenting with diffuse alveolar hemorrhage and negative antineutrophilic cytoplasmic antibody test. (16933823)
2006
33
Intestinal perforation and jejunal haemorrhage due to Wegener's granulomatosis. (15789904)
2005
34
Activation, apoptosis, and clearance of neutrophils in Wegener's granulomatosis. (16126939)
2005
35
Orbital socket contracture: a complication of inflammatory orbital disease in patients with Wegener's granulomatosis. (15774931)
2005
36
Aneurysmal subarachnoid hemorrhage in a patient with Wegener's granulomatosis. (15480908)
2004
37
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. (12700924)
2003
38
Wegener's granulomatosis presenting as acute suppurative interstitial nephritis. (11577128)
2001
39
Facial paralysis in Wegener's granulomatosis of the middle ear. (11276335)
2001
40
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis. (10464553)
1999
41
Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis. (9875021)
1998
42
Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. (9355084)
1997
43
The phylogeny of proteinase 3/myeloblastin, the autoantigen in Wegener's granulomatosis, and myeloperoxidase as shown by immunohistochemical studies on human leukemic cell lines. (8261669)
1994
44
A diagnostic dilemma: Wegener's granulomatosis, relapsing polychondritis or both? (8258052)
1993
45
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (1400430)
1992
46
Distribution pattern of proteinase 3 in Wegener's granulomatosis and other vasculitic diseases]. (2060965)
1991
47
Scleritis and Wegener's granulomatosis in children. (1882959)
1991
48
Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. (1688612)
1990
49
Small intestinal perforation in Wegener's granulomatosis. (7100026)
1982
50
Subacute meningitis heralding a diffuse granulomatous angiitis: (Wegener's granulomatosis?). (557762)
1977

Variations for Wegener's Granulomatosis

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Expression for genes affiliated with Wegener's Granulomatosis

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Expression patterns in normal tissues for genes affiliated with Wegener's Granulomatosis

Search GEO for disease gene expression data for Wegener's Granulomatosis.

Pathways for genes affiliated with Wegener's Granulomatosis

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Pathways related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CTLA4, CD28, HLA-DPB1
2
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.5CD28, MS4A2, HLA-DPB1
3
Show member pathways
9.5TNFRSF4, TNFRSF18, TNFSF9
49.4CTLA4, CD28, SELE, HLA-DPB1
5
Show member pathways
9.4CTLA4, CD28, MS4A2, HLA-DPB1
69.3CTLA4, CD28, CXCL6, HLA-DPB1
7
Show member pathways
9.3HLA-DPB1, TNFRSF4, TNFRSF18, TNFSF9
8
Show member pathways
9.2XCL1, CCL21, CCR4, CXCL6
9
Show member pathways
9.2CXCL6, CCR4, CCL21, XCL1
10
Show member pathways
9.2CXCL6, CCR4, CCL21, XCL1
11
Show member pathways
8.1CCL21, CCR4, CXCL6, TNFSF9, TNFRSF18, TNFRSF4
12
Show member pathways
8.1TNFRSF4, TNFRSF18, TNFSF9, CXCL6, CCR4, CCL21
13
Show member pathways
8.1TNFRSF4, TNFRSF18, TNFSF9, CXCL6, CCR4, CCL21
14
Show member pathways
7.7XCL1, TNFRSF4, TNFRSF18, TNFSF9, CXCL6, CCR4

Compounds for genes affiliated with Wegener's Granulomatosis

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Compounds related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.4PRTN3, MPO
2gliclazide44 50 1112.3MPO, SELE
3infliximab44 50 1112.3SELE, PRTN3, CTLA4
4teck4410.1CCL21, CCR4
5ctla4-ig4410.1CTLA4, CD28
6formaldehyde44 2411.1PRTN3, SELE, MPO
7larc4410.1CCR4, CCL21
8apocynin44 6110.9SELE, MPO
9dmso449.9MPO, SELE, PRTN3
10ccl344 2810.8XCL1, CCL21, CCR4
11ccl444 2810.8CCR4, CCL21, XCL1
12enterotoxin449.8CTLA4, CD28
13con a449.8CTLA4, CD28
14ionomycin449.8CTLA4, CD28, PRTN3, TNFRSF4
15groalpha449.7CXCL6, SELE
16genistein44 28 61 2 24 1114.6SELE, SULT1A3, PRTN3, CD28
17heparin44 28 24 1112.6MPO, SELE, SULT1A3, XCL1
18creatinine449.6MPO, SELE, SULT1A3, IL18BP
19tacrolimus44 50 1111.6CTLA4, XCL1, CD28
20cyclosporin a44 28 6111.5TNFRSF4, CD28, XCL1, CTLA4
21lipid449.2SELE, SULT1A3, PRTN3, CCR4, CD28, CTLA4
22rantes449.2CTLA4, SELE, CXCL6, CCR4, CCL21, XCL1
23serine448.9MPO, SERPINA2, SELE, PRTN3, CXCL6, CD28
24calcium44 50 24 1111.5MPO, PRTN3, CXCL6, CCR4, CCL21, CD28

GO Terms for genes affiliated with Wegener's Granulomatosis

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Cellular components related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7CTLA4, TNFRSF4, TNFRSF18, MS4A2, CCR4, CD28
2integral component of plasma membraneGO:0058878.5TNFRSF4, TNFRSF18, MS4A2, CCR4, CD28, CTLA4
3extracellular regionGO:0055768.3SERPINA2, CXCL6, CCL21, IL18BP, XCL1, TNFRSF18
4extracellular spaceGO:0056158.0TNFSF9, MPO, SERPINA2, SELE, CXCL6, CCL21
5plasma membraneGO:0058867.9HLA-DPB1, TNFSF9, SELE, PRTN3, MS4A2, CCR4

Biological processes related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1release of sequestered calcium ion into cytosolGO:0512099.8XCL1, CCL21
2response to lipopolysaccharideGO:0324969.5MPO, SELE, IL18BP
3positive regulation of neutrophil chemotaxisGO:0900239.5XCL1, CCL21
4T cell costimulationGO:0312959.3HLA-DPB1, CCL21, CD28, CTLA4
5cell-cell signalingGO:0072679.2XCL1, CCL21, CXCL6, TNFSF9
6inflammatory responseGO:0069549.0TNFRSF4, SELE, CXCL6, MS4A2, CCR4, CCL21
7immune responseGO:0069558.4CTLA4, TNFRSF4, TNFSF9, CXCL6, MS4A2, CCR4

Molecular functions related to Wegener's Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.8TNFRSF18, TNFRSF4
2chemokine receptor bindingGO:0423799.5XCL1, CCL21
3chemokine activityGO:0080099.4XCL1, CCL21, CXCL6

Products for genes affiliated with Wegener's Granulomatosis

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Sources for Wegener's Granulomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet