MCID: WLL006
MIFTS: 49

Wells Syndrome malady

Skin diseases category

Summaries for Wells Syndrome

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42NIH Rare Diseases, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Many people in the United States receive their water from private ground water wells. EPA regulations that protect public drinking water systems do not apply to privately owned wells. As a result, owners of private wells are responsible for ensuring that their water is safe from contaminants. Here you may find information on the basics of wells, proper methods of siting and location for wells, all about testing and how often to test a well, proper treatment of wells and maintenance of wells , information on well retirement, common diseases and contaminants associated with wells, emergency treatment of wells, and answers to frequently asked questions about wells.

MalaCards: Wells Syndrome, also known as eosinophilic cellulitis, is related to muckle-wells syndrome and ankyloblepharon-ectodermal defects-cleft lip/palate syndrome, and has symptoms including vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment, follicular/erythematous/edematous papules/milium and erythema/erythematous lesions/erythroderma/polymorphous erythema. An important gene associated with Wells Syndrome is NLRP3 (NLR family, pyrin domain containing 3), and among its related pathways are Senescence and Autophagy and Spinal Cord Injury. The compounds p005 and tenidap have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related mouse phenotypes are renal/urinary system and integument.

NIH Rare Diseases:42 Wells syndrome is a rare eosinophilic disorder characterized by itchy, burning, red, and inflamed areas on the skin often on the lower arm or leg. the lesions may be single or multiple. they are usually red at first (looking like cellulitis) then change to brown red, to blue gray, then greenish gray. the lesions are usually painful and are sometimes associated with a fever. they typically heal without scarring within weeks to months; however they often recur. the cause of wells syndrome is unknown; but some researchers think that wells syndrome is an autoimmune reaction. last updated: 12/14/2011

Wikipedia:63 Eosinophilic cellulitus (also known as \"Wells\' syndrome\" from George Crichton Wells who first... more...

Aliases & Classifications for Wells Syndrome

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
wells syndrome:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

wells syndrome 42 48 60
eosinophilic cellulitis 42 48
bullous cellulitis with eosinophilia 42
wells' syndrome 42


External Ids:

MESH via Orphanet35 C536693
ICD10 via Orphanet26 L98.3
UMLS via Orphanet61 C0343101
ICD1025 L98.3

Related Diseases for Wells Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Wells Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1muckle-wells syndrome30.7IL1B, IL1RAPL2, IL1R1, MEFV, TNFRSF1A, CASP1
2ankyloblepharon-ectodermal defects-cleft lip/palate syndrome30.4FGFR2, TP63
3dermatitis30.1NLRP3
4eosinophilia30.1IL8, IL3
5amyloidosis30.1TNFRSF1A, CRP, MEFV, IL1RAPL2
6urticaria30.0NLRP3, CASP1, IL1RAPL2
7adenocarcinoma30.0CASP1, GNB2L1, FGFR2, IL1RAPL2, TP63
8uveitis29.7IL1R1, TNFRSF1A
9asthma29.7IL1B, IL8, IL3
10arthropathy29.7NLRP3, CRP, IL1RAPL2, IL1B
11multiple sclerosis29.7CASP1, TNFRSF1A, IL1R1, IL1RAPL2, IL1B
12herpes simplex29.7CASP1, FGFR2, IL1RAPL2
13familial cold autoinflammatory syndrome29.7NLRP3, IL1B, IL1R1, MEFV, TNFRSF1A, CASP1
14systemic lupus erythematosus29.7TNFRSF1A, CRP, IL1R1, IL1RAPL2
15ulcerative colitis29.7CASP1, CRP, IL1R1, IL1RAPL2, IL8, IL1B
16cellulitis10.6
17churg-strauss syndrome10.2
18folliculitis10.2
19granulomatous dermatitis10.0
20burns10.0
21thromboangiitis obliterans10.0
22fasciitis10.0
23lung adenocarcinoma10.0
24panniculitis10.0
25pericarditis10.0MEFV
26schnitzler syndrome10.0IL1R1
27ischemia10.0CASP1
28alopecia areata10.0IL1R1
29colon cancer10.0CASP1
30palindromic rheumatism10.0MEFV
31cervical cancer10.0IL1R1
32influenza10.0CASP1
33polyarteritis nodosa10.0MEFV
34gingivitis10.0IL1B
35diabetic retinopathy10.0CASP1
36acquired immunodeficiency syndrome10.0IL1B
37down syndrome10.0CASP1
38hepatitis b10.0TNFRSF1A
39common variable immune deficiency10.0TNFRSF1A
40hepatitis10.0IL1RAPL2
41encephalitis10.0IL1B
42bronchiolitis10.0IL8
43dementia10.0IL1RAPL2
44crohn's disease10.0CRP
45allergic rhinitis10.0IL8
46insulinoma10.0CASP1
47rhinitis10.0IL8
48periodontal disease10.0CRP
49amyotrophic lateral sclerosis10.0CASP1
50pancreas disease10.0CASP1

Graphical network of the top 20 diseases related to Wells Syndrome:



Diseases related to wells syndrome

Clinical Features for Wells Syndrome

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48Orphanet
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Symptoms:

48 (show all 10)
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • follicular/erythematous/edematous papules/milium
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • urticaria
  • eosinophils anomalies/hypereosinophilia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cutaneous edema
  • pruritus/itching
  • cutaneous rash
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue

Drugs & Therapeutics for Wells Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Wells Syndrome

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Anatomical Context for Wells Syndrome

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32MalaCards
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MalaCards organs/tissues related to Wells Syndrome:

32
Skin, Testes

Animal Models for Wells Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Wells Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.3NLRP3, FGFR2, IL1R1, AVP
2MP:00107719.1NLRP3, CASP1, MEFV, FGFR2, IL1R1
3MP:00020068.7CASP1, TNFRSF1A, FGFR2, IL1R1, IL1B, TP63
4MP:00053858.3TNFRSF1A, CRP, FGFR2, IL1R1, IL1B, TP63
5MP:00053978.0NLRP3, CASP1, TNFRSF1A, MEFV, FGFR2, IL3
6MP:00053877.4TP63, NLRP3, CASP1, TNFRSF1A, CRP, MEFV
7MP:00053767.2NLRP3, CASP1, TNFRSF1A, CRP, MEFV, FGFR2
8MP:00107687.2NLRP3, CASP1, TNFRSF1A, MEFV, FGFR2, IL3

Publications for Wells Syndrome

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Genetic Variations for Wells Syndrome

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Expression for genes affiliated with Wells Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wells Syndrome

Search GEO for disease gene expression data for Wells Syndrome.

Pathways for genes affiliated with Wells Syndrome

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 52R&D Systems
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Pathways related to Wells Syndrome according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL8
210.0IL1B, IL1R1
39.9IL1B, CASP1
4
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9.8MEFV, CASP1, NLRP3
5
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9.8FGFR2, TNFRSF1A
6
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9.7IL1R1, TNFRSF1A, CASP1
7
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9.7IL1B, IL1R1, CASP1
89.6IL1B, IL1R1, IL3
99.6IL1R1, IL8, IL1B
10
Immune response Bacterial infections in normal airways
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9.6IL1R1, IL8, IL1B
11
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9.6IL1B, IL8, IL1R1
129.6CASP1, IL8, IL1B
139.6CASP1, IL8, IL1B
149.5IL1B, IL8, IL3
15
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9.5FGFR2, GNB2L1
16
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9.4CASP1, TNFRSF1A, IL1R1, IL1B
17
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9.4CASP1, IL3, IL1R1, IL1B
18
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9.4IL1B, IL1R1, IL3, CASP1
199.4IL1B, IL8, CASP1, NLRP3
209.3TNFRSF1A, IL1R1, IL8, IL1B
21
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9.2IL1R1, IL3, FGFR2, TNFRSF1A
22
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9.2CASP1, TNFRSF1A, FGFR2, IL3
23
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9.1IL1B, IL8, MEFV, CASP1, NLRP3
24
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9.1NLRP3, CASP1, IL1R1, IL8, IL1B
25
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9.1CASP1, TNFRSF1A, IL3, IL1R1, IL1B
26
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9.0IL1B, IL1R1, FGFR2, TNFRSF1A, CASP1
27
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8.9TNFRSF1A, FGFR2, IL3, IL1R1, IL1B
28
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8.9CASP1, TNFRSF1A, FGFR2, IL3, IL1B
29
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8.6NLRP3, CASP1, GNB2L1, TNFRSF1A, IL8, IL1B
30
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8.6TNFRSF1A, FGFR2, IL3, IL1R1, IL8, IL1B
31
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8.5NLRP3, CASP1, MEFV, FGFR2, IL3, IL1R1

Compounds for genes affiliated with Wells Syndrome

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Wells Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1p0054410.5TP63
2tenidap44 2811.4IL1R1
3cycloheximide4410.4IL1RAPL2
4endotoxin4410.2MEFV, TNFRSF1A, CASP1
5diphenyleneiodonium4410.0CASP1, IL1B, IL1R1
6fmlp449.9IL1RAPL2, IL3
7tlck449.9CASP1, IL1B, IL8
8pentoxifylline44 1110.9IL1R1, CASP1, IL1RAPL2
9muramyl dipeptide44 2810.8CASP1, IL1B, IL8
10as 10159 4410.8IL1B, IL3, CASP1, IL1R1
11lxa4449.7IL3, IL8, IL1B
12mevalonate449.7NLRP3, MEFV, TNFRSF1A, CASP1
13peptidoglycan44 2810.6IL8, IL1R1, IL1B, CASP1
14poly(i-c)449.6IL8, IL1B, IL3, CASP1
15monosodium urate449.5IL1B, IL1R1, IL1RAPL2, IL8
16leflunomide49 44 1111.5IL1RAPL2, TNFRSF1A, IL1B, IL1R1
17polysulfone449.4CRP, IL1B, IL1R1, IL1RAPL2
18cuprophan449.3IL1R1, TNFRSF1A, IL1B, IL1RAPL2, CASP1
19rantes449.2IL1R1, TNFRSF1A, IL3, IL1RAPL2, IL1B
20mip 1alpha449.2IL8, IL1B, IL3
21infliximab44 49 1111.2TNFRSF1A, IL1B, IL1RAPL2, IL1R1, CRP
22il 10449.2IL1B, IL8, IL1RAPL2, IL1R1, IL3
23leukotriene b444 59 2411.1IL1B, IL1RAPL2, IL1R1, IL3, IL8
24sulfasalazine44 28 49 1112.1IL1B, IL1R1, CRP, IL1RAPL2, IL8
25dexamethasone44 49 28 1112.1CASP1, IL3, IL1R1, IL1RAPL2, AVP
26glutamate449.1TNFRSF1A, GNB2L1, IL1RAPL2, AVP
27sb 20358044 5910.1CASP1, IL8, IL1R1, CRP, IL1B, TNFRSF1A
28anakinra44 1110.0CASP1, CRP, IL1R1, IL1RAPL2, IL1B, NLRP3
29creatinine449.0IL1RAPL2, CASP1, TNFRSF1A, CRP, AVP
30methotrexate44 49 1111.0NLRP3, TNFRSF1A, CRP, IL1R1, IL1RAPL2, IL1B
31ivig448.9IL3, CRP, TNFRSF1A, IL1R1, IL1B, IL1RAPL2
32etanercept44 49 1110.9IL8, IL1RAPL2, IL1R1, TNFRSF1A, IL1B, CRP
33cyclophosphamide44 49 1110.9CRP, IL3, IL1RAPL2, IL1R1, FGFR2
34ribonucleic acid448.8CASP1, TNFRSF1A, FGFR2, IL1R1, IL1B, IL1RAPL2
35aspirin44 49 28 2411.8IL1R1, IL1B, CASP1, CRP, IL1RAPL2
36h2o2448.7TNFRSF1A, IL1RAPL2, IL1R1, IL3, FGFR2, CASP1
37actinomycin d448.7CASP1, TNFRSF1A, IL3, IL1R1, IL8, IL1B
38cyclosporin a44 28 5910.6IL8, IL1RAPL2, CASP1, TNFRSF1A, IL3, IL1R1
39neopterin448.6TNFRSF1A, CRP, IL1RAPL2, IL8, IL1R1, IL1B
40cisplatin44 49 59 1111.5FGFR2, IL1R1, TP63, IL3, TNFRSF1A, CASP1
41lactate448.5IL1RAPL2, CRP, CASP1, IL8, IL3, IL1R1
42n acetylcysteine448.4IL8, IL1R1, IL3, TNFRSF1A, CASP1, IL1B
43thymidine44 249.4IL1B, TP63, FGFR2, IL3, IL1R1, IL1RAPL2
44retinoic acid44 249.2CASP1, TP63, IL1B, IL1RAPL2, IL1R1, IL3
45testosterone44 59 11 2411.1CASP1, TP63, IL1RAPL2, IL1R1, IL3, FGFR2
46nitric oxide44 11 2410.1FGFR2, CASP1, IL1RAPL2, TNFRSF1A, IL1R1, IL8
47serine448.1IL1R1, TNFRSF1A, IL1RAPL2, IL8, GNB2L1, CASP1
48vegf447.9TP63, CASP1, IL1B, IL8, IL1RAPL2, IL1R1
49threonine447.7AVP, IL1RAPL2, IL1R1, IL3, FGFR2, TNFRSF1A
50tyrosine447.3IL1R1, GNB2L1, TNFRSF1A, MEFV, FGFR2, CASP1

GO Terms for genes affiliated with Wells Syndrome

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16Gene Ontology
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Cellular components related to Wells Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NLRP3 inflammasome complexGO:0725599.7CASP1, NLRP3
2extracellular spaceGO:0056158.5CRP, IL3, IL8, IL1B, AVP, TNFRSF1A
3extracellular regionGO:0055767.4AVP, CASP1, TNFRSF1A, CRP, FGFR2, IL3

Biological processes related to Wells Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.2IL1B, CASP1
2nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.0NLRP3, CASP1, MEFV
3squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentGO:06052910.0TP63, FGFR2
4negative regulation of inflammatory responseGO:05072810.0MEFV, TNFRSF1A, NLRP3
5cellular response to organic substanceGO:0713109.9IL1B, CASP1
6cellular response to mechanical stimulusGO:0712609.8CASP1, TNFRSF1A, IL1B
7response to ATPGO:0331989.8CASP1, IL1B
8positive regulation of interleukin-1 beta secretionGO:0507189.7CASP1, NLRP3
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.5NLRP3, CASP1, GNB2L1
10response to ethanolGO:0454719.5AVP, CRP, TNFRSF1A
11immune responseGO:0069559.3IL1B, IL8, IL1R1, IL3
12cell-cell signalingGO:0072679.2AVP, IL1B, IL3, FGFR2
13inflammatory responseGO:0069549.0IL1B, IL8, MEFV, CRP, TNFRSF1A, NLRP3
14apoptotic processGO:0069159.0NLRP3, CASP1, TNFRSF1A, FGFR2, IL1B, TP63

Molecular functions related to Wells Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:0049089.7IL1RAPL2, IL1R1

Products for genes affiliated with Wells Syndrome

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Sources for Wells Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet