Aliases & Classifications for Wells Syndrome

MalaCards integrated aliases for Wells Syndrome:

Name: Wells Syndrome 49 55 69
Eosinophilic Cellulitis 49 55
Bullous Cellulitis with Eosinophilia 49
Wells' Syndrome 49

Characteristics:

Orphanet epidemiological data:

55
wells syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA901
MESH via Orphanet 42 C536693
UMLS via Orphanet 70 C0343101
ICD10 via Orphanet 33 L98.3
ICD10 32 L98.3
UMLS 69 C0343101

Summaries for Wells Syndrome

NIH Rare Diseases : 49 Wells syndrome is a rare eosinophilic disorder that primarily affects the skin. Affected people typically develop a skin rash that is often proceeded by itching or burning skin. The rash consists of raised, red, swollen areas that may be warm to the touch. The symptoms generally come on rapidly and may last four to eight weeks. In some cases, the rash may recur (occur frequently or repeatedly) for years. The exact underlying cause of Wells syndrome is currently unknown; however, some scientists believe that it may be an autoimmune reaction. Oral or topical corticosteroids are commonly used to treat Wells syndrome, although antifungal drugs, antibiotics, immunosuppressants, and/or antihistamines have also been used with varying degrees of success. Last updated: 4/27/2015

MalaCards based summary : Wells Syndrome, also known as eosinophilic cellulitis, is related to ankyloblepharon-ectodermal defects-cleft lip/palate and muckle-wells syndrome, and has symptoms including pruritus, cellulitis and edema. An important gene associated with Wells Syndrome is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Vaccines and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and myeloid, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Many people in the United States receive their water from private ground water wells. EPA regulations that protect public drinking water systems do not apply to privately owned wells. As a result, owners of private wells are responsible for ensuring that their water is safe from contaminants. Here you may find information on the basics of wells, proper methods of siting and location for wells, all about testing and how often to test a well, proper treatment of wells and maintenance of wells , information on well retirement, common diseases and contaminants associated with wells, emergency treatment of wells, and answers to frequently asked questions about wells.

Wikipedia : 72 Eosinophilic cellulitis, also known as Wells\' syndrome, is a skin disease that presents with painful,... more...

Related Diseases for Wells Syndrome

Diseases related to Wells Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 ankyloblepharon-ectodermal defects-cleft lip/palate 33.3 FGFR2 TP63
2 muckle-wells syndrome 32.7 CRP IL1B IL1R1 MEFV NLRP3 TNFRSF1A
3 cryopyrin-associated periodic syndrome 31.3 CRP IL1R1 NLRP3
4 familial cold autoinflammatory syndrome 1 30.6 IL1B IL1R1 MEFV NLRP3 TNFRSF1A
5 cellulitis 29.9 CRP IL1R1 IL5 RNASE3
6 amyloidosis 29.7 MEFV NLRP3 TNFRSF1A
7 familial cold autoinflammatory syndrome 29.5 IL1B IL1R1 NLRP3
8 tetanus 29.4 IL2 IL2RA IL5
9 hypereosinophilic syndrome 29.4 CXCL8 IL2RA IL5 RNASE3
10 cold urticaria 29.3 IL1R1 IL1RAPL2 NLRP3 RNASE3
11 allergic asthma 29.1 CXCL8 IL5 RNASE3
12 multiple sclerosis 28.7 IL1B IL2 IL2RA IL5 TNFRSF1A
13 ulcerative colitis 28.5 CRP CXCL8 IL1B IL2
14 asthma 28.0 CXCL8 IL1B IL1R1 IL2RA IL5 NLRP3
15 psoriatic juvenile idiopathic arthritis 10.5 MEFV NLRP3
16 inflammatory myopathy with abundant macrophages 10.5 MEFV TNFRSF1A
17 intermittent hydrarthrosis 10.5 MEFV TNFRSF1A
18 tinea favosa 10.5 IL1B NLRP3
19 systemic onset juvenile idiopathic arthritis 10.5 IL1B MEFV
20 loeffler endocarditis 10.4 IL5 RNASE3
21 cervical adenitis 10.4 IL1B MEFV NLRP3
22 blau syndrome 10.4 IL1B MEFV NLRP3
23 idiopathic recurrent pericarditis 10.4 MEFV TNFRSF1A
24 aphthous stomatitis 10.4 IL1B MEFV NLRP3
25 periodic fever, familial, autosomal dominant 10.4 MEFV NLRP3 TNFRSF1A
26 conjunctival disease 10.4 IL5 NLRP3 RNASE3
27 stomatitis 10.3 IL1B MEFV TP63
28 blepharoconjunctivitis 10.3 FGFR2 RNASE3
29 recurrent corneal erosion 10.3 CXCL8 IL1B
30 mycobacterium kansasii 10.3 CXCL8 NLRP3
31 vulvar vestibulitis syndrome 10.3 IL1B IL1R1 NLRP3
32 schnitzler syndrome 10.3 IL1B IL1R1 NLRP3
33 paragonimiasis 10.3 IL5 RNASE3
34 cough variant asthma 10.3 IL5 RNASE3
35 joint disorders 10.3 IL1B IL1R1 IL1RAPL2
36 vernal conjunctivitis 10.3 IL2 IL2RA RNASE3
37 atopic keratoconjunctivitis 10.2 IL2 IL5 RNASE3
38 erysipeloid 10.2 MEFV NLRP3
39 alopecia areata 10.2 IL1B IL2 IL2RA
40 mumps 10.2 IL2 IL2RA TNFRSF1A
41 silicosis 10.2 CXCL8 IL1B NLRP3
42 pyoderma gangrenosum 10.2 CXCL8 MEFV NLRP3
43 onchocerciasis 10.2 IL2 IL5 RNASE3
44 pneumoconiosis 10.2 CXCL8 IL1B NLRP3
45 acquired immunodeficiency syndrome 10.2 IL1B IL2 IL2RA
46 toxicodendron dermatitis 10.2 CXCL8 IL2
47 radiculopathy 10.2 IL1R1 IL2RA IL5
48 extrinsic allergic alveolitis 10.2 CXCL8 IL1B IL2RA
49 schistosomiasis 10.2 IL2 IL5 RNASE3
50 bagassosis 10.2 CXCL8 IL1B IL5

Graphical network of the top 20 diseases related to Wells Syndrome:



Diseases related to Wells Syndrome

Symptoms & Phenotypes for Wells Syndrome

Human phenotypes related to Wells Syndrome:

55 31 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 55 31 hallmark (90%) Very frequent (99-80%) HP:0000989
2 cellulitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0100658
3 edema 55 31 frequent (33%) Frequent (79-30%) HP:0000969
4 eosinophilia 55 31 frequent (33%) Frequent (79-30%) HP:0001880
5 abnormal blistering of the skin 55 31 frequent (33%) Frequent (79-30%) HP:0008066
6 skin vesicle 55 31 frequent (33%) Frequent (79-30%) HP:0200037
7 fever 55 31 occasional (7.5%) Occasional (29-5%) HP:0001945
8 arthralgia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002829
9 vasculitis 55 Excluded (0%)

GenomeRNAi Phenotypes related to Wells Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.72 TNFRSF1A CXCL8 IL1B IL2 IL2RA NLRP3
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.72 TNFRSF1A TP63 CXCL8 IL1B IL2 IL2RA

MGI Mouse Phenotypes related to Wells Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 HNRNPAB IL1B MEFV IL1R1 NLRP3 IL2
2 growth/size/body region MP:0005378 10.14 IL5 IL1B MEFV IL1R1 NLRP3 RACK1
3 immune system MP:0005387 10.06 IL1B MEFV IL1R1 NLRP3 IL2 CRP
4 digestive/alimentary MP:0005381 9.98 IL5 NLRP3 IL2 IL2RA FGFR2 TP63
5 integument MP:0010771 9.86 IL1B MEFV IL1R1 NLRP3 RACK1 FGFR2
6 liver/biliary system MP:0005370 9.7 IL5 MEFV IL1R1 NLRP3 IL2 FGFR2
7 neoplasm MP:0002006 9.5 IL1B IL1R1 IL2 FGFR2 IL5 TP63
8 respiratory system MP:0005388 9.17 IL5 IL1R1 IL2 IL2RA FGFR2 TP63

Drugs & Therapeutics for Wells Syndrome

Drugs for Wells Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Antibodies, Monoclonal Phase 3,Phase 2
3 Immunoglobulins Phase 3,Phase 2
4 Antibodies Phase 3,Phase 2
5 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome Completed NCT00465985 Phase 3 ACZ885;Placebo
2 Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT00685373 Phase 3 Canakinumab (ACZ885)
3 Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase Completed NCT00991146 Phase 3 canakinumab
4 Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT01576367 Phase 3
5 Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT01302860 Phase 3 ACZ885
6 Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) Completed NCT00288704 Phase 3 rilonacept 160 mg;Placebo;rilonacept 160 mg
7 The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada Completed NCT01105507 Phase 3 canakinumab (company code: ACZ885D)
8 A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies Active, not recruiting NCT02334748 Phase 3 canakinumab
9 Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) Completed NCT01045772 Phase 2 rilonacept
10 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
11 Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms Completed NCT00487708 Phase 2 canakinumab
12 HL2351 CAPS Phase II Study Terminated NCT02853084 Phase 2 HL2351
13 A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease Withdrawn NCT01211977 Phase 1, Phase 2 XOMA 052
14 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
15 Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients Completed NCT01213641

Search NIH Clinical Center for Wells Syndrome

Genetic Tests for Wells Syndrome

Anatomical Context for Wells Syndrome

MalaCards organs/tissues related to Wells Syndrome:

38
Skin, Testes, Myeloid, Monocytes, B Cells, Neutrophil, T Cells

Publications for Wells Syndrome

Articles related to Wells Syndrome:

(show top 50) (show all 219)
# Title Authors Year
1
Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature. ( 29382382 )
2018
2
Wells syndrome (eosinophilic cellulitis) caused by adrenal insufficiency and relieved by cortisone supplementation. ( 29398098 )
2018
3
Wells' syndrome-like reaction following Argas reflexus bites. ( 29400289 )
2018
4
Expanding the genetic profile of Hay-Wells syndrome. ( 29329681 )
2018
5
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome. ( 28229991 )
2017
6
Bullous Pesentation of Idiopathic Wells Syndrome (Eosinophilic Cellulitis). ( 28920134 )
2017
7
Periodic fever: From Still's disease to Muckle-Wells syndrome. ( 28583784 )
2017
8
Wells Syndrome with Bullous Lesions. ( 28351790 )
2017
9
Muckle-Wells syndrome: clinical perspectives. ( 28744167 )
2017
10
A rare form of ankyloblepharon filiforme adnatum associated with the Hay-Wells syndrome and a c.1709T>C mutation on the TP63 gene. ( 29140732 )
2017
11
Wells syndrome associated with lung cancer. ( 28951508 )
2017
12
Wells' Syndrome Successfully Treated with Colchicine. ( 28868003 )
2017
13
Placental Transfer of Canakinumab in a Patient with Muckle-Wells Syndrome. ( 28386702 )
2017
14
Wells syndrome secondary to influenza vaccination: A case report and review of the literature. ( 29240526 )
2017
15
Muckle-Wells syndrome in the setting of basal cell nevus syndrome. ( 28686751 )
2017
16
A Case of Amyloidosis Caused by Sporadic Muckle-Wells Syndrome: Response to Treatment With Anakinra. ( 29239931 )
2017
17
Endometriosis in the setting of Muckle-Wells syndrome treated with an IL-1I^ antagonist. ( 28508753 )
2017
18
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review. ( 27357601 )
2016
19
Muckle-Wells Syndrome: A Case Report with an NLRP3 T348M Mutation. ( 27435956 )
2016
20
Wells syndrome. ( 27767278 )
2016
21
Muckle-Wells syndrome in Chinese patients: a single center case series. ( 28028683 )
2016
22
Wells' syndrome with a clinicopathological correlation associated with mantle-cell lymphoma. ( 26999270 )
2016
23
Early detection of sensorineural hearing loss in Muckle-Wells-syndrome. ( 26531310 )
2015
24
Muckle-Wells syndrome: a rare hereditary cryopyrin-associated periodic syndrome. ( 26218404 )
2015
25
Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome. ( 25839890 )
2015
26
Wells syndrome associated with chronic lymphocytic leukemia. ( 26375230 )
2015
27
Wells' Syndrome Mimicking Facial Cellulitis: A Report of Two Cases. ( 26120307 )
2015
28
Muckle-Wells syndrome in an Indian family associated with NLRP3 mutation. ( 25766347 )
2015
29
Influenza Vaccination as a Novel Trigger of Wells Syndrome in a Child. ( 25894853 )
2015
30
Budget Impact Analysis of Canacinumab In The Treatment of Patients With Muckle-Wells Syndrome In The Russian Federation. ( 26533715 )
2015
31
Muckle wells syndrome associated with multifocal clinically isolated syndrome. ( 24618190 )
2014
32
Recurrent paraneoplastic wells syndrome in a patient with metastatic renal cell cancer. ( 24945651 )
2014
33
Wells syndrome: response to dapsone therapy. ( 25143695 )
2014
34
Life of Lesions in Eosinophilic Cellulitis (Wells' Syndrome)-A Condition That May Be Missed at First Sight. ( 25238447 )
2014
35
Syndrome in question. Hay-Wells syndrome. ( 24770526 )
2014
36
Wells syndrome. ( 24505587 )
2014
37
Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1I^ monoclonal antibody canakinumab. ( 24510061 )
2014
38
Eosinophilic leukocytoclastic vasculitis - a spectrum ranging from Wells' syndrome to Churg-Strauss syndrome? ( 25115356 )
2014
39
IgG4-related disease of the paratestis in a patient with Wells syndrome: a case report. ( 25487870 )
2014
40
Eosinophilic cellulitis (Wells' syndrome) caused by a temporary henna tattoo. ( 25395929 )
2014
41
Hearing loss in Muckle-Wells syndrome. ( 23440695 )
2013
42
Renal and thyroid amyloidosis secondary tocryopyrin-associated periodic syndrome(Muckle-Wells syndrome) (NLRP3 mutation). ( 23511763 )
2013
43
Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes. ( 24326009 )
2013
44
Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1I^ and rapid response to anakinra. ( 23889084 )
2013
45
Eosinophilic annular erythema is a peculiar subtype in the spectrum of Wells syndrome: a multicentre long-term follow-up study. ( 22731886 )
2013
46
Wells' syndrome associated with Churg-Strauss syndrome: correlation with mast cell distribution. ( 22998535 )
2013
47
Treatment of Muckle-Wells syndrome: analysis of two IL-1-blocking regimens. ( 23718630 )
2013
48
Muckle-Wells syndrome: individualized, reflare-guided dosing of the orphan drug canakinumab. ( 23745225 )
2013
49
Muckle-Wells syndrome: a treatable cause of congenital sensorineural hearing loss. ( 23909124 )
2013
50
Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant. ( 24421864 )
2013

Variations for Wells Syndrome

Expression for Wells Syndrome

Search GEO for disease gene expression data for Wells Syndrome.

Pathways for Wells Syndrome

Pathways related to Wells Syndrome according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CRP CXCL8 FGFR2 IL1B IL1R1 IL2
2
Show member pathways
13.75 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
3
Show member pathways
13.6 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
4
Show member pathways
13.48 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
5
Show member pathways
13.34 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
6
Show member pathways
13.27 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
7
Show member pathways
13.12 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
8 12.77 CXCL8 FGFR2 IL2 IL2RA IL5
9
Show member pathways
12.74 CXCL8 IL1B IL2 IL2RA IL5 RNASE3
10
Show member pathways
12.64 FGFR2 IL1B IL1R1 IL2 TNFRSF1A
11
Show member pathways
12.56 CXCL8 IL1B IL2 IL2RA NLRP3 RACK1
12
Show member pathways
12.55 IL1B IL1R1 IL2 IL2RA IL5
13 12.49 IL1B IL2 IL2RA TNFRSF1A
14
Show member pathways
12.47 CXCL8 IL1B IL2 TNFRSF1A
15 12.37 IL1R1 IL2 IL2RA TNFRSF1A
16
Show member pathways
12.09 CXCL8 IL1B IL2 IL5
17
Show member pathways
12.05 FGFR2 IL1B IL1R1 IL2 IL2RA IL5
18 11.96 CXCL8 IL1B IL1R1 IL2
19 11.92 IL2 IL2RA IL5
20
Show member pathways
11.9 IL1B IL1R1 IL2 IL2RA
21 11.83 CXCL8 IL1B IL1R1
22 11.78 IL1B IL1R1 IL2RA IL5
23 11.76 CXCL8 IL1B IL1R1 TNFRSF1A
24
Show member pathways
11.75 IL1B IL1R1 IL2 IL2RA IL5
25 11.74 CXCL8 IL2 IL5
26 11.7 CXCL8 IL1B NLRP3
27 11.61 CXCL8 IL1B IL5
28
Show member pathways
11.61 CXCL8 IL2 IL2RA IL5
29
Show member pathways
11.5 CXCL8 IL1B IL2 TNFRSF1A
30 11.46 IL2 IL2RA IL5
31 11.39 IL1B MEFV NLRP3
32 11.36 CXCL8 IL1B IL1R1 TNFRSF1A
33
Show member pathways
11.33 IL2 IL2RA TNFRSF1A
34 11.22 IL1B IL2 IL5
35 11.15 CXCL8 IL1B IL2 IL5
36 11.08 IL1B IL1R1 NLRP3
37 10.97 CXCL8 FGFR2 IL1B IL2 IL5
38 10.92 IL1B IL1R1 IL2 IL2RA IL5
39 10.78 IL2 IL2RA IL5 TNFRSF1A
40 10.75 IL1B IL5

GO Terms for Wells Syndrome

Cellular components related to Wells Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 CRP CXCL8 FGFR2 IL1B IL1R1 IL2

Biological processes related to Wells Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.87 FGFR2 IL1B IL2RA NLRP3 RACK1 TNFRSF1A
2 MAPK cascade GO:0000165 9.8 FGFR2 IL1B IL2 IL2RA IL5
3 defense response to Gram-positive bacterium GO:0050830 9.72 CRP NLRP3 RNASE3
4 immune response GO:0006955 9.7 CXCL8 IL1B IL1R1 IL2 IL2RA IL5
5 positive regulation of T cell proliferation GO:0042102 9.67 IL1B IL2 IL2RA
6 cytokine-mediated signaling pathway GO:0019221 9.65 IL1B IL1R1 IL1RAPL2 IL5 TNFRSF1A
7 positive regulation of T cell differentiation GO:0045582 9.58 IL2 IL2RA
8 regulation of regulatory T cell differentiation GO:0045589 9.56 IL2 IL2RA
9 positive regulation of immunoglobulin secretion GO:0051024 9.54 IL2 IL5
10 positive regulation of ceramide biosynthetic process GO:2000304 9.52 RACK1 TNFRSF1A
11 regulation of establishment of endothelial barrier GO:1903140 9.51 IL1B TNFRSF1A
12 negative regulation of lymphocyte proliferation GO:0050672 9.48 IL2 IL2RA
13 interleukin-1 beta production GO:0032611 9.46 IL1B NLRP3
14 regulation of T cell homeostatic proliferation GO:0046013 9.43 IL2 IL2RA
15 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0060529 9.37 FGFR2 TP63
16 negative regulation of inflammatory response GO:0050728 9.35 IL2 IL2RA MEFV NLRP3 TNFRSF1A
17 inflammatory response GO:0006954 9.23 CRP CXCL8 IL1B IL2RA IL5 MEFV
18 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 FGFR2 IL1B IL2 NLRP3 TNFRSF1A TP63

Molecular functions related to Wells Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CXCL8 IL1B IL2 IL5
2 interleukin-1 receptor activity GO:0004908 8.96 IL1R1 IL1RAPL2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 FGFR2 IL2 IL2RA IL5

Sources for Wells Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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