MCID: WLL006
MIFTS: 62

Wells Syndrome malady

Rare diseases, Skin diseases categories

Summaries for Wells Syndrome

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44NIH Rare Diseases, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 Many people in the United States receive their water from private ground water wells. EPA regulations that protect public drinking water systems do not apply to privately owned wells. As a result, owners of private wells are responsible for ensuring that their water is safe from contaminants. Here you may find information on the basics of wells, proper methods of siting and location for wells, all about testing and how often to test a well, proper treatment of wells and maintenance of wells , information on well retirement, common diseases and contaminants associated with wells, emergency treatment of wells, and answers to frequently asked questions about wells.

MalaCards: Wells Syndrome, also known as eosinophilic cellulitis, is related to muckle-wells syndrome and ankyloblepharon-ectodermal defects-cleft lip/palate syndrome, and has symptoms including vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment, cutaneous rash and pruritus/itching. An important gene associated with Wells Syndrome is NLRP3 (NLR family, pyrin domain containing 3), and among its related pathways are TRAF Pathway and Monoamine Transport. The compounds as 101 and tlck have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and kidney, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

NIH Rare Diseases:44 Wells syndrome is a rare eosinophilic disorder characterized by itchy, burning, red, and inflamed areas on the skin often on the lower arm or leg. the lesions may be single or multiple. they are usually red at first (looking like cellulitis) then change to brown red, to blue gray, then greenish gray. the lesions are usually painful and are sometimes associated with a fever. they typically heal without scarring within weeks to months; however they often recur. the cause of wells syndrome is unknown; but some researchers think that wells syndrome is an autoimmune reaction. last updated: 12/14/2011

Wikipedia:66 Eosinophilic cellulitus (also known as \"Wells\' syndrome\" from George Crichton Wells who first... more...

Aliases & Classifications for Wells Syndrome

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Sources:
44NIH Rare Diseases, 50Orphanet, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 50 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

50
wells syndrome:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

wells syndrome 44 50 63
eosinophilic cellulitis 44 50
bullous cellulitis with eosinophilia 44
wells' syndrome 44


External Ids:

MESH via Orphanet37 C536693
ICD10 via Orphanet27 L98.3
UMLS via Orphanet64 C0343101
ICD1026 L98.3

Related Diseases for Wells Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Wells Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1muckle-wells syndrome31.2IL1R1, MEFV, TNFRSF1A, IL1RAPL2, IL1B, CASP1
2ankyloblepharon-ectodermal defects-cleft lip/palate syndrome30.6TP63, FGFR2
3ectodermal dysplasia30.3TNFRSF1A, TP63
4amyloidosis30.3MEFV, TNFRSF1A, CRP, IL1RAPL2
5urticaria30.2CASP1, IL1RAPL2, NLRP3
6familial cold autoinflammatory syndrome30.0NLRP3, CASP1, IL1B, IL1R1, MEFV, TNFRSF1A
7adenocarcinoma30.0CASP1, FGFR2, GNB2L1, TP63, IL1RAPL2
8amyloidosis, secondary29.9MEFV, CRP
9arthropathy29.8CRP, IL1RAPL2, IL1B, NLRP3
10systemic lupus erythematosus29.8TNFRSF1A, IL1R1, IL1RAPL2, CRP
11multiple sclerosis29.8CASP1, IL1B, IL1RAPL2, TNFRSF1A, IL1R1
12herpes simplex29.8CASP1, IL1RAPL2, FGFR2
13ulcerative colitis29.7IL1R1, IL1RAPL2, IL1B, CRP, IL8, CASP1
14cellulitis10.6
15churg-strauss syndrome10.3
16folliculitis10.2
17eosinophilic pustular folliculitis10.2
18dermatitis10.1
19eosinophilia10.1
20palindromic rheumatism10.1MEFV
21polyarteritis nodosa10.1MEFV
22schnitzler syndrome10.1IL1R1
23pericarditis10.1MEFV
24adult-onset still's disease10.1CRP
25leukemoid reaction10.1IL3
26felty's syndrome10.1IL3
27septic arthritis10.1CRP
28pyoderma gangrenosum10.1NLRP3, MEFV
29aseptic meningitis10.1IL1R1, NLRP3
30common cold10.1IL8
31bronchitis10.1CRP
32periodic fever, familial, autosomal dominant10.1MEFV, TNFRSF1A
33bacteriuria10.1CRP
34relapsing fever10.1MEFV, TNFRSF1A
35conjunctivitis10.1NLRP3, TNFRSF1A
36pleurisy10.1IL1B, MEFV
37granulomatous dermatitis10.1
38hypereosinophilic syndrome10.1
39familial mediterranean fever10.1TNFRSF1A, NLRP3, MEFV
40blau syndrome10.1IL1B, NLRP3, MEFV
41cowpox10.1TNFRSF1A, CASP1
42exanthem10.1NLRP3, CRP
43bronchiolitis10.1IL8
44gout10.1IL1B, NLRP3
45polymyalgia rheumatica10.1IL1RAPL2, CRP
46spondylarthropathy10.1CRP, IL1RAPL2
47shigellosis10.1IL1R1, CASP1, IL1B
48slow-channel congenital myasthenic syndrome10.1CRP, IL8
49burns10.1
50thromboangiitis obliterans10.1

Graphical network of the top 20 diseases related to Wells Syndrome:



Diseases related to wells syndrome

Symptoms for Wells Syndrome

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50Orphanet
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Symptoms:

50 (show all 10)
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • cutaneous rash
  • pruritus/itching
  • cutaneous edema
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • eosinophils anomalies/hypereosinophilia
  • urticaria
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue

Drugs & Therapeutics for Wells Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Wells Syndrome

Drug clinical trials:

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Search NIH Clinical Center for Wells Syndrome

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Genetic Tests for Wells Syndrome

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Anatomical Context for Wells Syndrome

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34MalaCards
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MalaCards organs/tissues related to Wells Syndrome:

34
Skin, Testes, Kidney, Thyroid, Salivary gland, B cells, Myeloid, Monocytes, T cells, Colon, Brain

Animal Models for Wells Syndrome or affiliated genes

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38MGI
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Publications for Wells Syndrome

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53PubMed
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Articles related to Wells Syndrome:

(show top 50)    (show all 177)
idTitleAuthorsYear
1
Eosinophilic cellulitis (Wells syndrome) in a pediatric patient: a case report and review of the literature. (22611749)
2012
2
Muckle-Wells syndrome and male hypofertility: a case series. (22512814)
2012
3
Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome. (21360513)
2011
4
NLRP3 E311K mutation in a large family with Muckle-Wells syndrome--description of a heterogeneous phenotype and response to treatment. (22146561)
2011
5
Hay-Wells syndrome of ectodermal dysplasia: A rare autosomal dominant disorder. (22346004)
2011
6
A patient with Wells' syndrome. (20500167)
2010
7
Improvement of sensoneurinal hearing loss in a patient with Muckle-Wells syndrome treated with anakinra]. (20135584)
2010
8
High responses of peripheral lymphocytes to mosquito salivary gland extracts in patients with Wells syndrome. (20542179)
2010
9
A case report of Wells' syndrome in a celiac patient. (20872333)
2010
10
Wells syndrome. (20411090)
2010
11
Wells Syndrome with Multiorgan Involvement Mimicking Hypereosinophilic Syndrome. (20652113)
2009
12
Craniofacial and anthropometric phenotype in ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (Hay-Wells syndrome) in a cohort of 17 patients. (19676059)
2009
13
Quiz page. Muckle Wells syndrome. (18971008)
2008
14
Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. (17989892)
2007
15
Hay-wells syndrome of ectodermal dysplasia. (16444073)
2006
16
Wells syndrome: an enigmatic and therapeutically challenging disease. (17039661)
2006
17
Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra. (16646042)
2006
18
A probable case of Muckle-Wells syndrome. (16556280)
2006
19
Rapp-Hodgkin ectodermal dysplasia syndrome: the clinical and molecular overlap with Hay-Wells syndrome. (16532463)
2006
20
Successful treatment of acute visual loss in Muckle-Wells syndrome with interleukin 1 receptor antagonist. (16014694)
2005
21
Bullous &quot;cellulitis&quot; with eosinophilia: case report and review of Wells' syndrome in childhood. (15995016)
2005
22
TNFRSF1A-associated periodic syndrome (TRAPS), Muckle-Wells syndrome (MWS) and renal amyloidosis. (12832748)
2003
23
Wells' syndrome: a clinical and histopathologic review of seven cases. (12581147)
2003
24
Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome). (12734477)
2003
25
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. (12815153)
2003
26
Wells syndrome. (14533832)
2003
27
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. (11992256)
2002
28
Nodular presentation of eosinophilic cellulitis (Wells' syndrome). (11722455)
2001
29
Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. (11159940)
2001
30
Eosinophilic cellulitis (Wells' syndrome) successfully treated with low-dose cyclosporine. (11641541)
2001
31
Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5. (10215782)
1999
32
Genetic linkage of the Muckle-Wells syndrome to chromosome 1q44. (10486324)
1999
33
Circadian elevation of IL-6 levels in Muckle-Wells syndrome: a disorder of the neuro-immune axis? (9797932)
1998
34
Wells' syndrome associated with idiopathic hypereosinophilic syndrome. (9470919)
1997
35
Wells' syndrome responsive to PUVA therapy. (9349363)
1997
36
Toxocariasis and Wells' syndrome: a causal relationship? (9529550)
1997
37
Congenital Wells syndrome. (9263317)
1997
38
Recurrent urticarial skin eruption since infancy. Muckle-Wells syndrome (MWS). (7826101)
1995
39
The arthropathy of the Muckle-Wells syndrome. (8000753)
1994
40
Iritis and Wells' syndrome. (1459774)
1992
41
Wells' syndrome in children: varicella infection as a precipitating event. (2004004)
1991
42
Amyloid goiter and arthritides after kidney transplantation in a patient with systemic amyloidosis and Muckle-Wells syndrome. (2589249)
1989
43
Eosinophilic infiltration with flame figures. A distinctive tissue reaction seen in Wells' syndrome and other diseases. (3728877)
1986
44
Eosinophilic cellulitis (Wells' syndrome) (4015127)
1985
45
Recurrent granulomatous dermatitis with eosinophilia. Wells' syndrome. (6724778)
1984
46
Eosinophilic cellulitis (Wells' syndrome): histologic and clinical features in arthropod bite reactions. (6512050)
1984
47
Wells' syndrome: is there collagen damage in the flame figures? (6520258)
1984
48
Identification of amyloid A protein in a sporadic Muckle-Wells syndrome. N-terminal amino acid sequence after isolation from formalin-fixed tissue. (6406764)
1983
49
The Muckle-Wells syndrome and the major histocompatibility complex. (6857626)
1983
50
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979

Variations for Wells Syndrome

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Expression for genes affiliated with Wells Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wells Syndrome

Search GEO for disease gene expression data for Wells Syndrome.

Pathways for genes affiliated with Wells Syndrome

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters, 62Tocris Bioscience, 55R&D Systems
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Pathways related to Wells Syndrome according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CASP1, TNFRSF1A
2
Show member pathways
Serotonin Transporter Activity39
9.9IL1B, IL1R1
39.9CASP1, IL1B
4
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.7IL1R1, IL1B, CASP1
59.6TNFRSF1A, IL1R1, IL1B
6
Show member pathways
9.6TNFRSF1A, IL1R1, IL1B
79.6TNFRSF1A, IL3, IL1R1
89.6IL1B, IL1R1, IL3
9
Show member pathways
9.5IL1B, IL3, TNFRSF1A
109.5IL8, GNB2L1
119.5IL1B, IL8, IL1R1
12
Show member pathways
Immune response MIF in innate immunity response61
9.5IL1B, IL8, IL1R1
139.5IL1R1, IL8, IL1B
149.5CASP1, IL1B, IL8
15
Show member pathways
9.5CASP1, IL1B, IL8
16
Show member pathways
9.5IL1R1, IL1B, FGFR2
179.4IL1B, IL8, IL3
189.4IL1B, IL8, IL3
19
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.4TNFRSF1A, TP63, IL1R1, CASP1
20
Show member pathways
9.3CASP1, IL1B, IL1R1, IL3
21
Show member pathways
9.3IL3, IL1R1, IL1B, CASP1
229.3NLRP3, CASP1, IL1B, IL8
239.2IL1B, IL8, IL1R1, TNFRSF1A
24
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.2TNFRSF1A, IL1R1, IL8, IL1B
25
Show member pathways
9.2TNFRSF1A, IL1R1, IL1B, FGFR2
26
Show member pathways
9.0NLRP3, CASP1, IL1B, IL8, MEFV
27
Show member pathways
9.0TNFRSF1A, IL3, IL1R1, IL1B, CASP1
28
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.0IL1R1, IL8, IL1B, CASP1, NLRP3
29
Show member pathways
MAPK signaling pathway39
8.9TNFRSF1A, IL1R1, IL1B, CASP1, FGFR2
30
Show member pathways
8.8TNFRSF1A, IL3, IL1R1, IL1B, FGFR2
31
Show member pathways
8.8TNFRSF1A, IL3, IL1B, CASP1, FGFR2
32
Show member pathways
8.5GNB2L1, TNFRSF1A, IL8, IL1B, CASP1, NLRP3
33
Show member pathways
8.4TNFRSF1A, IL3, IL1R1, IL8, IL1B, FGFR2
34
Show member pathways
8.4TNFRSF1A, IL3, IL1R1, IL8, IL1B, FGFR2
35
Show member pathways
8.2TNFRSF1A, IL3, IL1R1, IL8, IL1B, CASP1
36
Show member pathways
8.2TNFRSF1A, IL3, IL1R1, IL8, IL1B, CASP1
37
Show member pathways
7.9GNB2L1, TNFRSF1A, IL3, IL1R1, IL8, IL1B

Compounds for genes affiliated with Wells Syndrome

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Wells Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1as 10146 6210.7IL1B, CASP1, IL1R1, IL3
2tlck469.7IL8, IL1B, CASP1
3mevalonate469.7TNFRSF1A, MEFV, CASP1, NLRP3
4p005469.6IL1R1, CRP, TP63, TNFRSF1A
5tenidap46 3010.5IL1B, IL1R1, CRP
6diphenyleneiodonium469.5CASP1, IL1B, IL8, IL1R1
7peptidoglycan46 3010.5CASP1, IL1B, IL8, IL1R1
8poly(i-c)469.5IL8, CASP1, IL1B, IL3
9leflunomide46 52 1211.5IL1B, IL1RAPL2, IL1R1, TNFRSF1A
10adalimumab46 52 1211.4IL1RAPL2, TNFRSF1A, IL1R1, CRP
11monosodium urate469.4IL1B, IL8, IL1R1, IL1RAPL2
12polysulfone469.4IL1B, IL1RAPL2, IL1R1, CRP
13muramyl dipeptide46 3010.4IL8, CASP1, IL1B
14cuprophan469.3IL1B, IL1R1, IL1RAPL2, CASP1, TNFRSF1A
15infliximab46 52 1211.2TNFRSF1A, IL1RAPL2, IL1R1, CRP, IL1B
16pentoxifylline46 1210.1IL1RAPL2, IL1B, IL8, CASP1, IL1R1
17lxa4469.1IL1B, IL3, IL8
18il 10469.1IL3, IL1R1, IL1RAPL2, IL1B, IL8
19sulfasalazine30 46 52 1212.0IL1R1, IL1RAPL2, IL8, IL1B, CRP
20leukotriene b446 62 2511.0IL8, IL1B, IL1R1, IL1RAPL2, IL3
21anakinra46 1210.0IL1RAPL2, IL1R1, IL1B, CASP1, CRP, NLRP3
22sb 20358046 6210.0IL8, IL1B, CASP1, CRP, TNFRSF1A, IL1R1
23fmlp468.9IL1B, IL3, IL8, TNFRSF1A, IL1RAPL2
24methotrexate52 46 1210.9NLRP3, CRP, IL1B, IL1RAPL2, TNFRSF1A, IL1R1
25cyclophosphamide46 52 1210.9IL3, IL1R1, IL1RAPL2, CRP, FGFR2
26ivig468.8IL1RAPL2, IL1R1, IL3, CRP, IL1B, TNFRSF1A
27aspirin46 52 30 2511.8IL1R1, IL1RAPL2, CASP1, IL1B, CRP
28ribonucleic acid468.8FGFR2, CASP1, IL1B, IL1R1, TNFRSF1A, IL1RAPL2
29etanercept46 52 1210.8TNFRSF1A, IL1RAPL2, IL8, IL1B, CRP, IL1R1
30rantes468.8IL1RAPL2, IL1R1, TNFRSF1A, IL3, IL8, IL1B
31pge2468.7TNFRSF1A, CASP1, IL1B, IL1R1, IL1RAPL2, IL8
32cyclosporin a46 30 6210.7IL1R1, IL1RAPL2, TNFRSF1A, CASP1, IL8, IL3
33cisplatin46 52 62 1211.7IL3, FGFR2, IL1R1, TNFRSF1A, TP63, CASP1
34lactate468.5CASP1, IL8, IL1RAPL2, IL1R1, IL3, CRP
35actinomycin d468.5IL8, IL1B, CASP1, IL1RAPL2, IL3, TNFRSF1A
36neopterin468.4CRP, IL1B, IL8, IL1RAPL2, IL1R1, TNFRSF1A
37creatinine468.4IL1RAPL2, TNFRSF1A, IL3, CRP, IL1R1, CASP1
38dexamethasone46 52 30 1211.4IL1RAPL2, IL1R1, IL3, IL1B, CASP1, TNFRSF1A
39thymidine46 259.4IL3, IL1R1, IL1RAPL2, IL1B, TP63, FGFR2
40h2o2468.3IL1RAPL2, IL1R1, IL3, TNFRSF1A, IL8, CASP1
41nitric oxide46 25 1210.3FGFR2, IL1RAPL2, CASP1, IL1B, IL8, IL1R1
42endotoxin468.3IL8, IL1B, CRP, MEFV, TNFRSF1A, IL1R1
43n acetylcysteine468.2TNFRSF1A, FGFR2, IL1R1, IL8, IL1B, CRP
44cycloheximide468.1CRP, CASP1, IL1B, IL8, IL1RAPL2, IL1R1
45retinoic acid46 259.1IL1B, IL1R1, TNFRSF1A, IL1RAPL2, IL3, TP63
46testosterone46 62 25 1211.1FGFR2, IL1RAPL2, TP63, IL1R1, CASP1, CRP
47glutamate468.1TP63, IL1R1, IL1RAPL2, TNFRSF1A, FGFR2, GNB2L1
48threonine468.0IL1R1, IL3, TNFRSF1A, GNB2L1, IL1RAPL2, CASP1
49vegf467.7FGFR2, TP63, TNFRSF1A, IL1R1, IL1RAPL2, IL8
50tyrosine467.6IL3, CASP1, TP63, TNFRSF1A, IL1RAPL2, GNB2L1

GO Terms for genes affiliated with Wells Syndrome

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Sources:
17Gene Ontology
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Cellular components related to Wells Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NLRP3 inflammasome complexGO:0725599.7NLRP3, CASP1
2extracellular spaceGO:0056158.8IL3, IL8, IL1B, CRP, TNFRSF1A
3extracellular regionGO:0055767.7FGFR2, TNFRSF1A, IL3, IL1R1, IL8, IL1B

Biological processes related to Wells Syndrome according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-1 beta secretionGO:05071810.1CASP1, NLRP3
2response to ATPGO:03319810.1CASP1, IL1B
3cellular response to organic substanceGO:07131010.1IL1B, CASP1
4nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.0MEFV, CASP1, NLRP3
5squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentGO:06052910.0FGFR2, TP63
6negative regulation of inflammatory responseGO:05072810.0NLRP3, MEFV, TNFRSF1A
7interleukin-1 beta productionGO:03261110.0IL1B, CASP1, NLRP3
8cellular response to mechanical stimulusGO:0712609.9CASP1, IL1B, TNFRSF1A
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.7CASP1, IL1B, TNFRSF1A
10hair follicle morphogenesisGO:0310699.7FGFR2, TP63
11activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.7GNB2L1, CASP1, NLRP3
12response to hypoxiaGO:0016669.6TNFRSF1A, CASP1, CRP
13immune responseGO:0069559.4IL1B, IL8, IL1R1, IL3
14cytokine-mediated signaling pathwayGO:0192219.4IL1B, IL1RAPL2, TNFRSF1A
15innate immune responseGO:0450879.2MEFV, CASP1, NLRP3, FGFR2
16epithelial to mesenchymal transitionGO:0018379.1HNRNPAB, FGFR2
17inflammatory responseGO:0069549.0NLRP3, CRP, IL1B, IL8, MEFV, TNFRSF1A
18apoptotic processGO:0069158.9TNFRSF1A, TP63, IL1B, CASP1, NLRP3, FGFR2

Molecular functions related to Wells Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:0049089.6IL1RAPL2, IL1R1
2cysteine-type endopeptidase activator activity involved in apoptotic processGO:0086569.4CASP1, GNB2L1
3protein bindingGO:0055157.4TNFRSF1A, TP63, IL1R1, IL8, CASP1, CRP

Products for genes affiliated with Wells Syndrome

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  • Antibodies
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Sources for Wells Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet