MEN1
MCID: WRM001
MIFTS: 69

Wermer Syndrome (MEN1) malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Wermer Syndrome

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Sources:
48OMIM, 20GeneReviews, 34MalaCards
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MalaCards: Wermer Syndrome, also known as multiple endocrine neoplasia type 1, is related to hyperparathyroidism and neuroendocrine tumor, and has symptoms including cortico-adrenal hyperplasia/hypersecretion, thyroid anomalies and epigastralgia/heartburn/gastric/duodenal ulcer/gastritis. An important gene associated with Wermer Syndrome is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Oncogene Induced Senescence and Validated targets of C-MYC transcriptional repression. The compounds 111in-pentetreotide and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and pancreatic islet, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Description from OMIM:48 131100

GeneReviews summary for men1

Aliases & Classifications for Wermer Syndrome

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Sources:
9Disease Ontology, 20GeneReviews, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 46Novoseek, 63UMLS, 10diseasecard, 21GeneTests, 23GTR, 48OMIM, 41NCIt, 28ICD9CM, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

50
multiple endocrine neoplasia type 1:
Inheritance: Autosomal dominant,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

wermer syndrome 9 20 44 11 50
multiple endocrine neoplasia type 1 9 20 44 46 50 63
multiple endocrine neoplasia 1 10 21 23 48
men 1 44 50
endocrine adenomatosis multiple 44
multiple endocrine adenomatosis 20
wermer's syndrome 9
men1 syndrome 20
mea type i 9
men1 20


External Ids:

Disease Ontology9 DOID:10017
NCIt41 C3225
ICD9CM28 258.01
MeSH36 D018761
OMIM48 131100
SNOMED-CT59 30664006, 190566000
MESH via Orphanet37 D018761
ICD10 via Orphanet27 D44.8
SNOMED-CT via Orphanet60 30664006
UMLS via Orphanet64 C0025267

Related Diseases for Wermer Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Wermer Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism31.4CHGA, PRKAR1A, MEN1, GAST, CDC73, CDKN1B
2neuroendocrine tumor31.4PPY, CHGA, SST
3gastrinoma31.4PYGM, CHGA, SST, MEN1, GAST
4primary hyperparathyroidism31.3CHGA, PRKAR1A, MEN1, GAST, CDC73
5insulinoma31.3GAST, MEN1, SST, CHGA
6pituitary tumors31.0AIP, CHGA, PRKAR1A, SST, MEN1, CDKN1B
7islet cell tumor31.0SST, GAST
8prolactinoma30.9AIP, CHGA, PRKAR1A, SST, MEN1
9parathyroid carcinoma30.9CDC73, MEN1
10pituitary adenoma30.9AIP, CHGA, PRKAR1A, SST, MEN1, CDKN1B
11glucagonoma30.9CHGA, SST, MEN1, GAST
12adenoma30.8AIP, CHGA, PRKAR1A, SST, MEN1, GAST
13acromegaly30.8AIP, PRKAR1A, SST, MEN1
14pancreatic islet cell tumors30.8GAST, MEN1, SST, CHGA
15neuroendocrine carcinoma30.8CHGA, SST, MEN1, GAST
16familial isolated hyperparathyroidism30.8MEN1, CDC73
17adrenal adenoma30.8MEN1, PRKAR1A
18hypoglycemia30.6GAST, SST, CHGA, PPY
19hypercalcemia30.6CHGA, PRKAR1A, MEN1, GAST, CDC73
20pancreatic gastrinoma30.6PPP2R5B
21pancreatic cholera30.5SST, PPY
22gigantism30.5SST, AIP
23cushing's syndrome30.5SST, PRKAR1A
24lipomatosis30.5MEN1
25carney complex30.5AIP, PRKAR1A, MEN1, CDKN1B
26duodenal ulcer30.5PPY, SST, GAST
27vipoma30.4GAST, MEN1, SST, CHGA
28paraganglioma30.4GAST, MEN1, SST, CHGA
29carcinoid syndrome30.4CHGA, SST, MEN1, GAST
30pheochromocytoma30.4CHGA, SST, MEN1
31thyroid cancer30.3CDKN1B, CDKN1A, SST, PRKAR1A, CHGA
32meningioma30.3CDKN2B, CDKN2C, MEN1, SST
33parathyroid adenoma30.3CHGA, PRKAR1A, MEN1, CDC73, CDKN1B, CDKN2C
34hormone producing pituitary cancer30.2MEN1, AIP
35melanoma30.2JUND, CDKN1A, CDKN1B, CDKN2C, CDKN2B
36ovarian cancer30.2CDKN2C, CDKN1B, CDKN1A, JUND
37prostate cancer30.2JUND, CHGA, CDKN1A, CDKN1B, CDKN2C, CDKN2B
38zollinger-ellison syndrome30.2GAST, MEN1, SST, CHGA
39adenocarcinoma30.1JUND, CHGA, SST, MEN1, GAST, CDKN1A
40serotonin syndrome30.1CHGA, SST, MEN1, GAST
41multiple endocrine neoplasia30.0CHGA, CDKN1B, CDC73, GAST, PLCB3, MEN1
42multiple endocrine neoplasia type 2a30.0CDC73, MEN1
43hyperglycemia29.9SST, PYGM, PPY
44pancreatic cancer29.8CDKN1A, GAST, SST
45lung cancer29.7CDKN2B, CDKN2C, CDKN1B, CDKN1A, CHGA
46hepatocellular carcinoma29.7JUND, MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
47breast cancer29.7PYGM, JUND, PRKAR1A, MEN1, CDKN1A, CDKN1B
48leukemia29.7JUND, MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
49pancreatitis11.0
50pancreatic endocrine tumors10.7

Graphical network of the top 20 diseases related to Wermer Syndrome:



Diseases related to wermer syndrome

Symptoms for Wermer Syndrome

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48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

131100

Clinical features from OMIM:

131100

Symptoms:

50 (show all 13)
  • cortico-adrenal hyperplasia/hypersecretion
  • thyroid anomalies
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • xanthomas/lipomas
  • autosomal dominant inheritance
  • neoplasms/tumors
  • hypercalcemia
  • anomaly of pancreatic hormones
  • hyperparathyroidy
  • parathyroids anomalies
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • anomalies of the endocrine glands
  • structural anomalies of the pancreas

Drugs & Therapeutics for Wermer Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Wermer Syndrome

Drug clinical trials:

Search ClinicalTrials for Wermer Syndrome

Search NIH Clinical Center for Wermer Syndrome

Search CenterWatch for Wermer Syndrome

Genetic Tests for Wermer Syndrome

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Sources:
21GeneTests, 23GTR
See all sources

Genetic tests related to Wermer Syndrome:

id Genetic test Affiliating Genes
1 Multiple Endocrine Neoplasia Type 121 MEN1
2 Multiple Endocrine Neoplasia, Type 123

Anatomical Context for Wermer Syndrome

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34MalaCards
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MalaCards organs/tissues related to Wermer Syndrome:

34
Pituitary, Thyroid, Pancreatic islet, Spinal cord, Hypothalamus, Pancreas

Animal Models for Wermer Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Wermer Syndrome:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0CHGA, CDC73, CDKN1A, CDKN1B, CDKN2C, CDKN2B
2MP:00053708.7AIP, JUND, MEN1, CDC73, CDKN1A, CDKN1B
3MP:00107718.6AIP, PLCB3, CDC73, CDKN1A, CDKN1B, CDKN2C
4MP:00053698.5PRKAR1A, MEN1, CDC73, CDKN1A, CDKN1B, JUND
5MP:00053888.4JUND, PRKAR1A, CDC73, CDKN1A, CDKN1B, CDKN2C
6MP:00020068.2AIP, PRKAR1A, MEN1, GAST, CDKN1A, CDKN1B
7MP:00053818.2PRKAR1A, SST, MEN1, GAST, CDC73, CDKN1A
8MP:00053808.1AIP, JUND, PRKAR1A, MEN1, PLCB3, CDC73
9MP:00053898.0JUND, CHGA, PRKAR1A, MEN1, CDC73, CDKN1A
10MP:00053857.9AIP, JUND, CHGA, PRKAR1A, MEN1, CDC73
11MP:00053977.8JUND, PRKAR1A, PLCB3, CDC73, CDKN1A, CDKN1B
12MP:00053847.7JUND, PRKAR1A, MEN1, CDC73, CDKN1A, CDKN1B
13MP:00053867.4PPY, JUND, SST, PLCB3, CDC73, CDKN1A
14MP:00053787.1PPY, AIP, JUND, CHGA, PRKAR1A, SST
15MP:00053797.0CDKN2B, AIP, JUND, CHGA, PRKAR1A, MEN1
16MP:00053876.6JUND, PRKAR1A, SST, MEN1, PLCB3, GAST
17MP:00107686.4MEN1, PRKAR1A, CHGA, JUND, AIP, PLCB3
18MP:00053766.1SST, PRKAR1A, CHGA, JUND, AIP, MEN1

Publications for Wermer Syndrome

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Sources:
53PubMed
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Articles related to Wermer Syndrome:

idTitleAuthorsYear
1
Image of the month. Wermer syndrome and Zollinger-Ellison syndrome. (19380653)
2009
2
Multiple endocrine neoplasia type 1. MEN1-- Wermer syndrome]. (15067750)
2003

Variations for Wermer Syndrome

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Wermer Syndrome:

65 (show all 90)
id Symbol AA change Variation ID SNP ID
1MEN1p.Pro12LeuVAR_005425
2MEN1p.Leu22ArgVAR_005426
3MEN1p.Glu26LysVAR_005427rs28931612
4MEN1p.Leu39TrpVAR_005428
5MEN1p.Gly42AspVAR_005429
6MEN1p.Glu45GlyVAR_005430
7MEN1p.His139AspVAR_005432
8MEN1p.His139TyrVAR_005433
9MEN1p.Lys135IleVAR_005434
10MEN1p.Phe144ValVAR_005436
11MEN1p.Ala165ProVAR_005437
12MEN1p.Ala169AspVAR_005438
13MEN1p.Asp177TyrVAR_005441
14MEN1p.Ala181ProVAR_005442
15MEN1p.Glu184AspVAR_005443
16MEN1p.Trp188SerVAR_005444
17MEN1p.Leu228ProVAR_005446
18MEN1p.Ala247ValVAR_005447
19MEN1p.Leu269ProVAR_005449
20MEN1p.Ala289GluVAR_005451
21MEN1p.Leu291ProVAR_005452
22MEN1p.Ala314ProVAR_005453
23MEN1p.Arg319ProVAR_005454
24MEN1p.Ala342AspVAR_005455rs2071312
25MEN1p.Trp346ArgVAR_005456
26MEN1p.Thr349ArgVAR_005457
27MEN1p.Glu364LysVAR_005458
28MEN1p.Ala373AspVAR_005460
29MEN1p.Asp423AsnVAR_005461
30MEN1p.Trp441ArgVAR_005464
31MEN1p.Phe452SerVAR_005465
32MEN1p.Ser560AsnVAR_005467
33MEN1p.Gly161AspVAR_008017
34MEN1p.Cys246ArgVAR_008018
35MEN1p.Glu45LysVAR_039587
36MEN1p.Arg98LeuVAR_039588
37MEN1p.Gly110GluVAR_039589
38MEN1p.His139ProVAR_039590
39MEN1p.His139ArgVAR_039591
40MEN1p.Asp158ValVAR_039592
41MEN1p.Ser159IleVAR_039593
42MEN1p.Ser160PheVAR_039594
43MEN1p.Ala165ThrVAR_039595
44MEN1p.Val167PheVAR_039596
45MEN1p.Cys170ArgVAR_039597
46MEN1p.Leu173ProVAR_039598
47MEN1p.Glu184LysVAR_039599
48MEN1p.Glu184GlnVAR_039600
49MEN1p.His186ArgVAR_039601
50MEN1p.Trp188ArgVAR_039602
51MEN1p.Val220MetVAR_039603
52MEN1p.Gly230ArgVAR_039604
53MEN1p.Arg234LeuVAR_039605
54MEN1p.Val245PheVAR_039606
55MEN1p.Cys246PheVAR_039607
56MEN1p.Cys246TyrVAR_039608
57MEN1p.Ser258ProVAR_039609
58MEN1p.Leu264ArgVAR_039611
59MEN1p.Gly286ArgVAR_039616
60MEN1p.Thr316ProVAR_039619
61MEN1p.His322ArgVAR_039620
62MEN1p.His322TyrVAR_039621
63MEN1p.Pro325LeuVAR_039622
64MEN1p.Pro325ArgVAR_039623
65MEN1p.Ala330ProVAR_039624
66MEN1p.Ala342ProVAR_039625
67MEN1p.Ala347ProVAR_039626
68MEN1p.Ile353AsnVAR_039627
69MEN1p.Tyr358AspVAR_039628
70MEN1p.Arg360TrpVAR_039629
71MEN1p.Asp362HisVAR_039630
72MEN1p.Ile377MetVAR_039631
73MEN1p.Pro378SerVAR_039632
74MEN1p.Ala390ValVAR_039633
75MEN1p.Ala416ProVAR_039634
76MEN1p.Leu419ProVAR_039635
77MEN1p.Arg420ProVAR_039636
78MEN1p.Asp423HisVAR_039637
79MEN1p.Cys426TyrVAR_039638
80MEN1p.Trp428SerVAR_039639
81MEN1p.Ser432ArgVAR_039640
82MEN1p.Trp441CysVAR_039641
83MEN1p.Leu449ProVAR_039642
84MEN1p.Arg532CysVAR_039643
85MEN1p.Pro545SerVAR_039644
86MEN1p.Pro549SerVAR_039645
87MEN1p.Ser560ArgVAR_039647
88MEN1p.Ile147PheVAR_065153
89MEN1p.Leu418ArgVAR_065155
90MEN1p.Trp476CysVAR_065156

Clinvar genetic disease variations for Wermer Syndrome:

1 (show all 29)
id Gene Name Type Significance SNP ID Assembly Location
1MEN1NM_000244.3(MEN1): c.65T> G (p.Leu22Arg)single nucleotide variantPathogenicrs104894256GRCh37Chr 11, 64577517: 64577517
2MEN1MEN1, 4-BP DEL, NT357deletionPathogenic
3MEN1MEN1, 1-BP DEL, 416CdeletionPathogenic
4MEN1MEN1, 3-BP DEL, LYS119DELdeletionPathogenic
5MEN1NM_000244.3(MEN1): c.402delC (p.Phe134Leufs)deletionPathogenicrs397515385GRCh37Chr 11, 64577180: 64577180
6MEN1NM_000244.3(MEN1): c.608G> A (p.Trp203Ter)single nucleotide variantPathogenicrs104894258GRCh37Chr 11, 64575424: 64575424
7MEN1MEN1, 4-BP DEL, NT735deletionPathogenic
8MEN1MEN1, 1-BP DEL, 1132GdeletionPathogenic
9MEN1MEN1, 3-BP DEL, GLU363DELdeletionPathogenic
10MEN1NM_000244.3(MEN1): c.1321T> A (p.Trp441Arg)single nucleotide variantPathogenicrs104894259GRCh37Chr 11, 64572550: 64572550
11MEN1NM_000244.3(MEN1): c.1322G> A (p.Trp441Ter)single nucleotide variantPathogenicrs104894260GRCh37Chr 11, 64572549: 64572549
12MEN1NM_000244.3(MEN1): c.1594C> T (p.Arg532Ter)single nucleotide variantPathogenicrs104894261GRCh37Chr 11, 64572060: 64572060
13MEN1NM_000244.3(MEN1): c.793C> T (p.Gln265Ter)single nucleotide variantPathogenicrs104894266GRCh37Chr 11, 64575029: 64575029
14MEN1NM_000244.3(MEN1): c.1393C> T (p.Arg465Ter)single nucleotide variantPathogenicrs104894267GRCh37Chr 11, 64572261: 64572261
15MEN1NM_000244.3(MEN1): c.415C> G (p.His139Asp)single nucleotide variantPathogenicrs104894263GRCh37Chr 11, 64577167: 64577167
16MEN1MEN1, IVS4, G-A, -9single nucleotide variantPathogenic
17MEN1MEN1, 3-BP DEL, 2641GAAdeletionPathogenic
18MEN1MEN1, 4-BP DEL, 4480CAGTdeletionPathogenic
19MEN1NM_000244.3(MEN1): c.1267G> A (p.Asp423Asn)single nucleotide variantPathogenicrs104894264GRCh37Chr 11, 64572604: 64572604
20MEN1MEN1, 1-BP DEL, 7773CdeletionPathogenic
21MEN1NM_000244.3(MEN1): c.1077C> A (p.Cys359Ter)single nucleotide variantPathogenicrs104894265GRCh37Chr 11, 64573230: 64573230
22MEN1MEN1, 6-BP INS, NT879insertionPathogenic
23MEN1MEN1, 12-BP DEL, NT1466deletionPathogenic
24MEN1MEN1, 1-BP INS, 1657CinsertionPathogenic
25MEN1MEN1, IVS5, G-A, +1single nucleotide variantPathogenic
26MEN1NM_000244.3(MEN1): c.211_212delCC (p.Pro71Alafs)deletionPathogenicrs386134251GRCh37Chr 11, 64577370: 64577371
27MEN1NM_000244.3(MEN1): c.518T> C (p.Leu173Pro)single nucleotide variantPathogenicrs386134256GRCh37Chr 11, 64575514: 64575514
28MEN1NM_000244.3(MEN1): c.951C> G (p.Tyr317Ter)single nucleotide variantLikely pathogenic, Pathogenicrs386134260GRCh37Chr 11, 64573817: 64573817
29MEN1MEN1, IVS3DS, G-A, +1single nucleotide variantPathogenic

Expression for genes affiliated with Wermer Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Wermer Syndrome

Search GEO for disease gene expression data for Wermer Syndrome.

Pathways for genes affiliated with Wermer Syndrome

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 5Cell Signaling Technology, 55R&D Systems, 61Thomson Reuters
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Pathways related to Wermer Syndrome according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CDKN2B, CDKN2C
29.8CDKN2B, CDKN1B, CDKN1A
3
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.8CDKN2B, CDKN1B, CDKN1A
49.8CDKN2B, CDKN1B, CDKN1A
59.8CDKN1A, CDKN1B, CDKN2C
69.5CDKN2C, CDKN1B, CDKN1A, MEN1
7
Show member pathways
9.5CDKN1A, CDKN1B, CDKN2C, CDKN2B
8
Show member pathways
Signaling Pathways in Glioblastoma39
9.5CDKN1A, CDKN1B, CDKN2C, CDKN2B
9
Show member pathways
9.5CDKN1A, CDKN1B, CDKN2C, CDKN2B
109.5CDKN1B, CDKN1A, PLCB3
11
Show member pathways
9.4CDC73, CDKN1A, CDKN1B, CDKN2C
12
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.4JUND, CDKN1A, CDKN1B
13
Show member pathways
Cell cycle39
9.3MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
14
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.3CDKN2B, CDKN1B, CDKN1A, PPP2R5B
159.2PRKAR1A, MEN1, CDKN1A, CDKN1B, CDKN2B
169.1CDKN2B, CDKN1B, CDKN1A, JUND
17
Show member pathways
AhR pathway39
9.1CDKN1B, CDKN1A, JUND, AIP
18
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
9.1PLCB3, PRKAR1A, PPP2R5B
19
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1JUND, PLCB3, CDKN1B
20
Show member pathways
9.0PPP2R5B, CDKN1A, CDKN1B, CDKN2C, CDKN2B
21
Show member pathways
9.0CDKN2B, CDKN2C, CDKN1B, CDKN1A, PPP2R5B
22
Show member pathways
8.8GAST, PLCB3, SST
23
Show member pathways
8.6PYGM, PRKAR1A, PLCB3, CDKN1A, CDKN1B, CDKN2B
24
Show member pathways
8.3PPP2R5B, JUND, PLCB3, CDKN1A, CDKN1B
25
Show member pathways
8.2PPP2R5B, PRKAR1A, PLCB3, CDKN1A, CDKN1B, CDKN2C
26
Show member pathways
7.5PPP2R5B, JUND, PRKAR1A, PLCB3, CDKN1A, CDKN1B
27
Show member pathways
6.5SST, PRKAR1A, PPY, PPP2R5B, MEN1, PLCB3

Compounds for genes affiliated with Wermer Syndrome

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB, 25HMDB, 62Tocris Bioscience
See all sources

Compounds related to Wermer Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide4610.2CHGA, SST
2flavopiridol46 1211.1PYGM, CDKN1A, CDKN1B
3cytarabine46 52 1212.0CDKN1A, CDKN1B, CDKN2B
4p0034610.0CHGA, CDKN1B, CDKN2B
5rpa 2469.9MEN1, JUND
65-hydroxytryptophan469.9SST, CHGA
7mibg469.8SST, CHGA
8azoxymethane469.8CDKN1B, GAST
9pepsinogen469.7GAST, CHGA
10minigastrin469.7SST, GAST
11lafutidine469.7SST, GAST
12caffeine46 30 3 52 25 1214.6PYGM, CHGA, SST
13loxiglumide469.6SST, GAST
14enprostil46 3010.6SST, GAST
15ciglitazone46 3010.6GAST, CDKN1A, CDKN1B
16bethanechol46 30 1211.6GAST, SST
17misoprostol46 1210.6GAST, CHGA
18celecoxib46 62 30 52 25 1214.5GAST, CDKN1A, CDKN1B
19phorbol469.5JUND, CHGA, CDKN1A
20peptidylglycine469.5GAST, CHGA
21pd 98,059469.5JUND, CDKN1A, CDKN1B, CDKN2B
22pantoprazole46 52 25 1212.5GAST, SST
2312-o-tetradecanoylphorbol 13-acetate469.5JUND, CHGA, CDKN1A, CDKN1B
24oxyntomodulin46 6210.4CHGA, SST, GAST
255-hydroxyindoleacetic acid46 2510.4GAST, SST, CHGA
26omeprazole46 52 30 25 1213.4GAST, SST, CHGA
27resveratrol46 62 25 1212.4GAST, CDKN1A, CDKN1B
28octreotide46 62 30 1212.4GAST, SST, CHGA
29c-peptide469.4GAST, SST, CHGA
30propranolol46 30 52 25 1213.3CHGA, SST, GAST
31bromodeoxyuridine469.3CHGA, GAST, CDKN1A, CDKN1B
32arginine469.3PYGM, CHGA, PRKAR1A, SST, CDKN1B
33threonine469.2JUND, CDKN1A, CDKN1B, CDKN2C, CDKN2B
34cycloheximide469.1JUND, CHGA, SST, CDKN1A, CDKN1B
35vitamin d469.0CHGA, PRKAR1A, MEN1, GAST, CDKN1A
36sb 20358046 629.9JUND, GAST, CDKN1A, CDKN1B
37retinoic acid46 259.9JUND, CHGA, SST, CDKN1A, CDKN1B, CDKN2B
38nifedipine46 30 52 1211.9GAST, SST, CHGA
39pge2468.8SST, GAST, CDKN1A, CDKN1B
40carbachol46 30 1210.8JUND, CHGA, SST, GAST
41thymidine46 259.8JUND, MEN1, GAST, CDKN1A, CDKN1B
42vegf468.7CHGA, SST, MEN1, GAST, CDKN1A, CDKN1B
43cisplatin46 52 62 1211.7JUND, CHGA, GAST, CDKN1A, CDKN1B
44glucose468.6PYGM, CHGA, PRKAR1A, SST, GAST, CDKN1B
45estrogen468.3CDKN2B, JUND, CHGA, MEN1, GAST, CDKN1A
46dexamethasone46 52 30 1211.3JUND, CHGA, PRKAR1A, SST, GAST, CDKN1B
47glutamate468.2JUND, CHGA, PRKAR1A, SST, GAST, CDKN1B
48tyrosine468.1PYGM, CHGA, MEN1, PLCB3, GAST, CDKN1A
49dopamine46 30 25 1211.1JUND, CHGA, SST, GAST
50serine468.0JUND, CHGA, MEN1, GAST, CDKN1A, CDKN1B

GO Terms for genes affiliated with Wermer Syndrome

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Sources:
17Gene Ontology
See all sources

Cellular components related to Wermer Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.5JUND, PRKAR1A, MEN1, PLCB3, CDKN1B
2nucleolusGO:0057308.1AIP, JUND, MEN1, PLCB3, CDKN1A, CDKN2B
3nucleusGO:0056347.6JUND, MEN1, PLCB3, CDC73, CDKN1A, CDKN1B
4cytosolGO:0058297.4CDKN2B, PPP2R5B, AIP, PYGM, PRKAR1A, MEN1

Biological processes related to Wermer Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:07185010.3CDKN1B, CDKN1A
2negative regulation of protein serine/threonine kinase activityGO:07190110.2CDKN2C, CDKN2B
3cellular response to extracellular stimulusGO:03166810.2CDKN2B, CDKN1A
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.1MEN1, CDKN1A, CDKN1B
5positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0CDKN2B, MEN1
6negative regulation of cell growthGO:03030810.0CDKN2C, CDKN1B, CDKN1A
7negative regulation of G1/S transition of mitotic cell cycleGO:200013410.0CDKN2B, CDC73
8G1/S transition of mitotic cell cycleGO:0000829.9CDKN1A, CDKN1B, CDKN2C
9negative regulation of phosphorylationGO:0423269.8CDKN2B, CDKN2C, CDKN1B, CDKN1A
10regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.8CDKN2B, CDKN2C, CDKN1B, CDKN1A
11osteoblast developmentGO:0020769.8MEN1, JUND
12mitotic cell cycleGO:0002789.7CDKN1A, CDKN1B, CDKN2C, CDKN2B
13epidermal growth factor receptor signaling pathwayGO:0071739.7CDKN1B, CDKN1A, PRKAR1A
14cell cycle arrestGO:0070509.6MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
15response to amino acidGO:0432009.6CDKN1B, SST
16fibroblast growth factor receptor signaling pathwayGO:0085439.6PRKAR1A, CDKN1A, CDKN1B
17negative regulation of cell proliferationGO:0082858.9CDKN2B, SST, MEN1, CDC73, CDKN1A, CDKN1B

Molecular functions related to Wermer Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.4CDKN2B, CDKN2C, CDKN1B, CDKN1A
2hormone activityGO:0051798.8GAST, SST, PPY
3protein bindingGO:0055155.7MEN1, PRKAR1A, JUND, AIP, PPP2R5B, DNAJC4

Products for genes affiliated with Wermer Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Wermer Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet