MEN1
MCID: WRM001
MIFTS: 70

Wermer Syndrome (MEN1) malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Wermer Syndrome

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MalaCards based summary: Wermer Syndrome, also known as multiple endocrine neoplasia type 1, is related to neuroendocrine tumor and insulinoma, and has symptoms including structural anomalies of the pancreas, anomalies of the endocrine glands and hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies. An important gene associated with Wermer Syndrome is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Oncogene Induced Senescence and Validated targets of C-MYC transcriptional repression. The compounds 111in-pentetreotide and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and pancreatic islet, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Description from OMIM:46 131100

GeneReviews summary for men1

Aliases & Classifications for Wermer Syndrome

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Sources:
8Disease Ontology, 9diseasecard, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Wermer Syndrome, Aliases & Descriptions:

Name: Wermer Syndrome 8 19 42 10 48
Multiple Endocrine Neoplasia Type 1 8 19 42 44 48 62
Multiple Endocrine Neoplasia 1 9 20 22 46
Men Type I 8 62
Men 1 42 48
Endocrine Adenomatosis, Multiple 62
 
Endocrine Adenomatosis Multiple 42
Multiple Endocrine Adenomatosis 19
Wermer's Syndrome 8
Men1 Syndrome 19
Men1 19


Classifications:



Characteristics (Orphanet epidemiological data):

48
multiple endocrine neoplasia type 1:
Inheritance: Autosomal dominant,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Adult


External Ids:

Disease Ontology8 DOID:10017
OMIM46 131100
MeSH34 D018761
NCIt39 C3225
SNOMED-CT57 30664006, 190566000
ICD9CM27 258.01
MESH via Orphanet35 D018761
ICD10 via Orphanet26 D44.8
UMLS via Orphanet63 C0025267

Related Diseases for Wermer Syndrome

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Diseases related to Wermer Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine tumor31.7SST, CHGA, PPY
2insulinoma31.4CHGA, MEN1, GAST, SST
3parathyroid carcinoma31.4MEN1, CDC73
4primary hyperparathyroidism31.3CDC73, CHGA, PRKAR1A, MEN1, GAST
5gastrinoma31.3SST, PYGM, CHGA, GAST, MEN1
6hyperparathyroidism31.3CHGA, CDKN1B, CDC73, GAST, MEN1, PRKAR1A
7pancreatic gastrinoma31.3PPP2R5B
8familial isolated hyperparathyroidism31.3MEN1, CDC73
9pancreatic islet cell tumors31.2SST, GAST
10adrenal adenoma31.2PRKAR1A, MEN1
11lipomatosis31.1MEN1
12glucagonoma31.0MEN1, CHGA, GAST, SST
13pancreatic cholera31.0PPY, SST
14acromegaly30.9MEN1, PRKAR1A, SST, AIP
15prolactinoma30.9SST, PRKAR1A, CHGA, MEN1, AIP
16gigantism30.9SST, AIP
17cushing's syndrome30.9PRKAR1A, SST
18neuroendocrine carcinoma30.8MEN1, CHGA, SST, GAST
19pituitary tumors30.8SST, MEN1, PRKAR1A, CDKN1B, CHGA, AIP
20hormone producing pituitary cancer30.8MEN1, AIP
21carney complex30.7CDKN1B, PRKAR1A, MEN1, AIP
22hypoglycemia30.7GAST, CHGA, SST, PPY
23duodenal ulcer30.7PPY, GAST, SST
24hypercalcemia30.6GAST, PRKAR1A, CHGA, CDC73, MEN1
25vipoma30.5SST, MEN1, CHGA, GAST
26paraganglioma30.5SST, MEN1, GAST, CHGA
27carcinoid syndrome30.5SST, MEN1, GAST, CHGA
28pheochromocytoma30.4MEN1, SST, CHGA
29pituitary adenoma30.4CDKN1B, CDKN2B, MEN1, SST, PRKAR1A, AIP
30multiple endocrine neoplasia type 2a30.4CDC73, MEN1
31zollinger-ellison syndrome30.2CHGA, GAST, MEN1, SST
32serotonin syndrome30.2GAST, CHGA, SST, MEN1
33meningioma30.0CDKN2C, MEN1, CDKN2B, SST
34hyperglycemia29.9SST, PYGM, PPY
35parathyroid adenoma29.9CDKN2C, CDKN1B, CDC73, MEN1, CHGA, PRKAR1A
36breast cancer29.8CDKN1B, CDKN1A, CDKN2C, MEN1, PYGM, JUND
37pancreatic cancer29.8GAST, SST, CDKN1A
38melanoma29.7CDKN2B, CDKN1A, JUND, CDKN1B, CDKN2C
39ovarian cancer29.7CDKN2C, CDKN1A, CDKN1B, JUND
40adenocarcinoma29.7MEN1, CHGA, JUND, SST, GAST, CDKN1B
41multiple endocrine neoplasia29.6PRKAR1A, GAST, PLCB3, CDKN1B, MEN1, CHGA
42adenoma29.6CDC73, CDKN1A, CDKN1B, CDKN2C, CHGA, GAST
43lung cancer29.1CDKN2C, CDKN1B, CDKN1A, CHGA, CDKN2B
44leukemia29.0CDKN2B, CDKN2C, CDKN1B, MEN1, JUND, CDKN1A
45pancreatitis11.1
46pancreatic endocrine tumors10.7
47islet cell tumor10.6
48duodenitis10.6
49pernicious anemia10.5GAST
50adrenocortical carcinoma10.4

Graphical network of the top 20 diseases related to Wermer Syndrome:



Diseases related to wermer syndrome

Symptoms for Wermer Syndrome

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Symptoms by clinical synopsis from OMIM:

131100

Clinical features from OMIM:

131100

Symptoms:

48 (show all 13)
  • structural anomalies of the pancreas
  • anomalies of the endocrine glands
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • parathyroids anomalies
  • hyperparathyroidy
  • anomaly of pancreatic hormones
  • hypercalcemia
  • neoplasms/tumors
  • autosomal dominant inheritance
  • xanthomas/lipomas
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • thyroid anomalies
  • cortico-adrenal hyperplasia/hypersecretion

HPO human phenotypes related to Wermer Syndrome:

(show all 28)
id Description Frequency HPO Source Accession
1 hyperparathyroidism hallmark (90%) HP:0000843
2 abnormality of the hypothalamus-pituitary axis hallmark (90%) HP:0000864
3 exocrine pancreatic insufficiency hallmark (90%) HP:0001738
4 hypercalcemia hallmark (90%) HP:0003072
5 abnormality of the thyroid gland typical (50%) HP:0000820
6 multiple lipomas typical (50%) HP:0001012
7 hypercortisolism typical (50%) HP:0001578
8 abnormality of the gastric mucosa typical (50%) HP:0004295
9 autosomal dominant inheritance HP:0000006
10 abnormality of the thyroid gland HP:0000820
11 growth hormone excess HP:0000845
12 cafe-au-lait spot HP:0000957
13 subcutaneous lipoma HP:0001031
14 hypercortisolism HP:0001578
15 hypoglycemia HP:0001943
16 diarrhea HP:0002014
17 zollinger-ellison syndrome HP:0002044
18 pituitary adenoma HP:0002893
19 parathyroid adenoma HP:0002897
20 hypercalcemia HP:0003072
21 peptic ulcer HP:0004398
22 pituitary prolactin cell adenoma HP:0006767
23 confetti-like hypopigmented macules HP:0007449
24 adrenocortical adenoma HP:0008256
25 adenoma sebaceum HP:0009720
26 insulinoma HP:0012197
27 carcinoid HP:0100570
28 esophagitis HP:0100633

Drugs & Therapeutics for Wermer Syndrome

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Drug clinical trials:

Search ClinicalTrials for Wermer Syndrome

Search NIH Clinical Center for Wermer Syndrome

Genetic Tests for Wermer Syndrome

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Genetic tests related to Wermer Syndrome:

id Genetic test Affiliating Genes
1 Multiple Endocrine Neoplasia Type 120 MEN1
2 Multiple Endocrine Neoplasia, Type 122

Anatomical Context for Wermer Syndrome

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MalaCards organs/tissues related to Wermer Syndrome:

32
Thyroid, Pituitary, Pancreatic islet, Spinal cord, Pancreas, Hypothalamus

Animal Models for Wermer Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Wermer Syndrome:

36 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0CHGA, CDC73, CDKN1A, CDKN1B, CDKN2C, CDKN2B
2MP:00053708.7AIP, JUND, MEN1, CDC73, CDKN1A, CDKN1B
3MP:00107718.6AIP, PLCB3, CDC73, CDKN1A, CDKN1B, CDKN2C
4MP:00053698.5PRKAR1A, MEN1, CDC73, CDKN1A, CDKN1B, JUND
5MP:00053888.4JUND, PRKAR1A, CDC73, CDKN1A, CDKN1B, CDKN2C
6MP:00020068.2AIP, PRKAR1A, MEN1, GAST, CDKN1A, CDKN1B
7MP:00053818.2PRKAR1A, SST, MEN1, GAST, CDC73, CDKN1A
8MP:00053808.1AIP, JUND, PRKAR1A, MEN1, PLCB3, CDC73
9MP:00053898.0JUND, CHGA, PRKAR1A, MEN1, CDC73, CDKN1A
10MP:00053857.9AIP, JUND, CHGA, PRKAR1A, MEN1, CDC73
11MP:00053977.8JUND, PRKAR1A, PLCB3, CDC73, CDKN1A, CDKN1B
12MP:00053847.7JUND, PRKAR1A, MEN1, CDC73, CDKN1A, CDKN1B
13MP:00053867.4PPY, JUND, SST, PLCB3, CDC73, CDKN1A
14MP:00053787.1PPY, AIP, JUND, CHGA, PRKAR1A, SST
15MP:00053797.0CDKN2B, AIP, JUND, CHGA, PRKAR1A, MEN1
16MP:00053876.6JUND, PRKAR1A, SST, MEN1, PLCB3, GAST
17MP:00107686.4MEN1, PRKAR1A, CHGA, JUND, AIP, PLCB3
18MP:00053766.1SST, PRKAR1A, CHGA, JUND, AIP, MEN1

Publications for Wermer Syndrome

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Articles related to Wermer Syndrome:

idTitleAuthorsYear
1
Image of the month. Wermer syndrome and Zollinger-Ellison syndrome. (19380653)
2009
2
Multiple endocrine neoplasia type 1. MEN1-- Wermer syndrome]. (15067750)
2003

Variations for Wermer Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wermer Syndrome:

64 (show all 90)
id Symbol AA change Variation ID SNP ID
1MEN1p.Pro12LeuVAR_005425
2MEN1p.Leu22ArgVAR_005426
3MEN1p.Glu26LysVAR_005427rs28931612
4MEN1p.Leu39TrpVAR_005428
5MEN1p.Gly42AspVAR_005429
6MEN1p.Glu45GlyVAR_005430
7MEN1p.His139AspVAR_005432
8MEN1p.His139TyrVAR_005433
9MEN1p.Lys135IleVAR_005434
10MEN1p.Phe144ValVAR_005436
11MEN1p.Ala165ProVAR_005437
12MEN1p.Ala169AspVAR_005438
13MEN1p.Asp177TyrVAR_005441
14MEN1p.Ala181ProVAR_005442
15MEN1p.Glu184AspVAR_005443
16MEN1p.Trp188SerVAR_005444
17MEN1p.Leu228ProVAR_005446
18MEN1p.Ala247ValVAR_005447
19MEN1p.Leu269ProVAR_005449
20MEN1p.Ala289GluVAR_005451
21MEN1p.Leu291ProVAR_005452
22MEN1p.Ala314ProVAR_005453
23MEN1p.Arg319ProVAR_005454
24MEN1p.Ala342AspVAR_005455rs2071312
25MEN1p.Trp346ArgVAR_005456
26MEN1p.Thr349ArgVAR_005457
27MEN1p.Glu364LysVAR_005458
28MEN1p.Ala373AspVAR_005460
29MEN1p.Asp423AsnVAR_005461
30MEN1p.Trp441ArgVAR_005464
31MEN1p.Phe452SerVAR_005465
32MEN1p.Ser560AsnVAR_005467
33MEN1p.Gly161AspVAR_008017
34MEN1p.Cys246ArgVAR_008018
35MEN1p.Glu45LysVAR_039587
36MEN1p.Arg98LeuVAR_039588
37MEN1p.Gly110GluVAR_039589
38MEN1p.His139ProVAR_039590
39MEN1p.His139ArgVAR_039591
40MEN1p.Asp158ValVAR_039592
41MEN1p.Ser159IleVAR_039593
42MEN1p.Ser160PheVAR_039594
43MEN1p.Ala165ThrVAR_039595
44MEN1p.Val167PheVAR_039596
45MEN1p.Cys170ArgVAR_039597
46MEN1p.Leu173ProVAR_039598
47MEN1p.Glu184LysVAR_039599
48MEN1p.Glu184GlnVAR_039600
49MEN1p.His186ArgVAR_039601
50MEN1p.Trp188ArgVAR_039602
51MEN1p.Val220MetVAR_039603
52MEN1p.Gly230ArgVAR_039604
53MEN1p.Arg234LeuVAR_039605
54MEN1p.Val245PheVAR_039606
55MEN1p.Cys246PheVAR_039607
56MEN1p.Cys246TyrVAR_039608
57MEN1p.Ser258ProVAR_039609
58MEN1p.Leu264ArgVAR_039611
59MEN1p.Gly286ArgVAR_039616
60MEN1p.Thr316ProVAR_039619
61MEN1p.His322ArgVAR_039620
62MEN1p.His322TyrVAR_039621
63MEN1p.Pro325LeuVAR_039622
64MEN1p.Pro325ArgVAR_039623
65MEN1p.Ala330ProVAR_039624
66MEN1p.Ala342ProVAR_039625
67MEN1p.Ala347ProVAR_039626
68MEN1p.Ile353AsnVAR_039627
69MEN1p.Tyr358AspVAR_039628
70MEN1p.Arg360TrpVAR_039629
71MEN1p.Asp362HisVAR_039630
72MEN1p.Ile377MetVAR_039631
73MEN1p.Pro378SerVAR_039632
74MEN1p.Ala390ValVAR_039633
75MEN1p.Ala416ProVAR_039634
76MEN1p.Leu419ProVAR_039635
77MEN1p.Arg420ProVAR_039636
78MEN1p.Asp423HisVAR_039637
79MEN1p.Cys426TyrVAR_039638
80MEN1p.Trp428SerVAR_039639
81MEN1p.Ser432ArgVAR_039640
82MEN1p.Trp441CysVAR_039641
83MEN1p.Leu449ProVAR_039642
84MEN1p.Arg532CysVAR_039643
85MEN1p.Pro545SerVAR_039644
86MEN1p.Pro549SerVAR_039645
87MEN1p.Ser560ArgVAR_039647
88MEN1p.Ile147PheVAR_065153
89MEN1p.Leu418ArgVAR_065155
90MEN1p.Trp476CysVAR_065156

Clinvar genetic disease variations for Wermer Syndrome:

6 (show all 42)
id Gene Name Type Significance SNP ID Assembly Location
1MEN1NM_000244.3(MEN1): c.65T> G (p.Leu22Arg)single nucleotide variantPathogenicrs104894256GRCh37Chr 11, 64577517: 64577517
2MEN1MEN1, 4-BP DEL, NT357deletionPathogenic
3MEN1MEN1, 1-BP DEL, 416CdeletionPathogenic
4MEN1MEN1, 3-BP DEL, LYS119DELdeletionPathogenic
5MEN1NM_000244.3(MEN1): c.402delC (p.Phe134Leufs)deletionPathogenicrs397515385GRCh37Chr 11, 64577180: 64577180
6MEN1NM_000244.3(MEN1): c.608G> A (p.Trp203Ter)single nucleotide variantPathogenicrs104894258GRCh37Chr 11, 64575424: 64575424
7MEN1MEN1, 4-BP DEL, NT735deletionPathogenic
8MEN1MEN1, 1-BP DEL, 1132GdeletionPathogenic
9MEN1MEN1, 3-BP DEL, GLU363DELdeletionPathogenic
10MEN1NM_000244.3(MEN1): c.1321T> A (p.Trp441Arg)single nucleotide variantPathogenicrs104894259GRCh37Chr 11, 64572550: 64572550
11MEN1NM_000244.3(MEN1): c.1322G> A (p.Trp441Ter)single nucleotide variantPathogenicrs104894260GRCh37Chr 11, 64572549: 64572549
12MEN1NM_000244.3(MEN1): c.1594C> T (p.Arg532Ter)single nucleotide variantPathogenicrs104894261GRCh37Chr 11, 64572060: 64572060
13MEN1NM_000244.3(MEN1): c.793C> T (p.Gln265Ter)single nucleotide variantPathogenicrs104894266GRCh37Chr 11, 64575029: 64575029
14MEN1NM_000244.3(MEN1): c.1393C> T (p.Arg465Ter)single nucleotide variantPathogenicrs104894267GRCh37Chr 11, 64572261: 64572261
15MEN1NM_000244.3(MEN1): c.415C> G (p.His139Asp)single nucleotide variantPathogenicrs104894263GRCh37Chr 11, 64577167: 64577167
16MEN1MEN1, IVS4, G-A, -9single nucleotide variantPathogenic
17MEN1MEN1, 3-BP DEL, 2641GAAdeletionPathogenic
18MEN1MEN1, 4-BP DEL, 4480CAGTdeletionPathogenic
19MEN1NM_000244.3(MEN1): c.1267G> A (p.Asp423Asn)single nucleotide variantPathogenicrs104894264GRCh37Chr 11, 64572604: 64572604
20MEN1MEN1, 1-BP DEL, 7773CdeletionPathogenic
21MEN1NM_000244.3(MEN1): c.1077C> A (p.Cys359Ter)single nucleotide variantPathogenicrs104894265GRCh37Chr 11, 64573230: 64573230
22MEN1MEN1, 6-BP INS, NT879insertionPathogenic
23MEN1MEN1, 12-BP DEL, NT1466deletionPathogenic
24MEN1MEN1, 1-BP INS, 1657CinsertionPathogenic
25MEN1MEN1, IVS5, G-A, +1single nucleotide variantPathogenic
26MEN1NM_000244.3(MEN1): c.1028dupT (p.Gln344Alafs)duplicationLikely pathogenicrs386134245GRCh37Chr 11, 64573739: 64573740
27MEN1NM_000244.3(MEN1): c.1078delC (p.Arg360Glyfs)deletionLikely pathogenicrs386134246GRCh37Chr 11, 64573229: 64573229
28MEN1NM_000244.3(MEN1): c.1189dupG (p.Glu397Glyfs)duplicationLikely pathogenicrs386134247GRCh37Chr 11, 64573117: 64573118
29MEN1NM_000244.3(MEN1): c.119_124delTGCTGG (p.Val40_Leu41del)deletionLikely pathogenicrs386134248GRCh37Chr 11, 64577458: 64577463
30MEN1NM_000244.3(MEN1): c.1277G> A (p.Cys426Tyr)single nucleotide variantLikely pathogenicrs386134249GRCh37Chr 11, 64572594: 64572594
31MEN1NM_000244.3(MEN1): c.1A> G (p.Met1Val)single nucleotide variantLikely pathogenicrs386134250GRCh37Chr 11, 64577581: 64577581
32MEN1NM_000244.3(MEN1): c.211_212delCC (p.Pro71Alafs)deletionPathogenicrs386134251GRCh37Chr 11, 64577370: 64577371
33MEN1NM_000244.3(MEN1): c.252dupT (p.Ile85Tyrfs)duplicationLikely pathogenicrs386134253GRCh37Chr 11, 64577329: 64577330
34MEN1NM_000244.3(MEN1): c.417C> G (p.His139Gln)single nucleotide variantLikely pathogenicrs386134254GRCh37Chr 11, 64577165: 64577165
35MEN1NM_000244.3(MEN1): c.480_481insAATT (p.Gly161Asnfs)insertionLikely pathogenicrs386134255GRCh37Chr 11, 64575551: 64575552
36MEN1NM_000244.3(MEN1): c.518T> C (p.Leu173Pro)single nucleotide variantPathogenicrs386134256GRCh37Chr 11, 64575514: 64575514
37MEN1NM_000244.3(MEN1): c.659_667delTGGCTGAGCinsGCCCCT (p.Val220_Arg223delinsGlyProTrp)indelLikely pathogenicrs386134257GRCh37Chr 11, 64575365: 64575373
38MEN1NM_000244.3(MEN1): c.664_669+2delGAGCGGGTdeletionLikely pathogenicrs386134258GRCh37Chr 11, 64575361: 64575368
39MEN1NM_000244.3(MEN1): c.773C> A (p.Ser258Ter)single nucleotide variantLikely pathogenicrs386134259GRCh37Chr 11, 64575049: 64575049
40MEN1NM_000244.3(MEN1): c.951C> G (p.Tyr317Ter)single nucleotide variantLikely pathogenicrs386134260GRCh37Chr 11, 64573817: 64573817
41MEN1NM_000244.3(MEN1): c.970dupT (p.Tyr324Leufs)duplicationLikely pathogenicrs386134261GRCh37Chr 11, 64573797: 64573798
42MEN1MEN1, IVS3DS, G-A, +1single nucleotide variantPathogenic

Expression for genes affiliated with Wermer Syndrome

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Expression patterns in normal tissues for genes affiliated with Wermer Syndrome

Search GEO for disease gene expression data for Wermer Syndrome.

Pathways for genes affiliated with Wermer Syndrome

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Pathways related to Wermer Syndrome according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CDKN2B, CDKN2C
29.8CDKN2B, CDKN1B, CDKN1A
3
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.8CDKN2B, CDKN1B, CDKN1A
49.8CDKN2B, CDKN1B, CDKN1A
59.8CDKN1A, CDKN1B, CDKN2C
69.5CDKN2C, CDKN1B, CDKN1A, MEN1
7
Show member pathways
9.5CDKN1A, CDKN1B, CDKN2C, CDKN2B
8
Show member pathways
Signaling Pathways in Glioblastoma37
9.5CDKN1A, CDKN1B, CDKN2C, CDKN2B
9
Show member pathways
9.5CDKN1A, CDKN1B, CDKN2C, CDKN2B
109.5CDKN1B, CDKN1A, PLCB3
11
Show member pathways
9.4CDC73, CDKN1A, CDKN1B, CDKN2C
12
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.4JUND, CDKN1A, CDKN1B
13
Show member pathways
Cell cycle37
9.3MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
14
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.3CDKN2B, CDKN1B, CDKN1A, PPP2R5B
159.2PRKAR1A, MEN1, CDKN1A, CDKN1B, CDKN2B
169.1CDKN2B, CDKN1B, CDKN1A, JUND
17
Show member pathways
AhR pathway37
9.1CDKN1B, CDKN1A, JUND, AIP
18
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.1PLCB3, PRKAR1A, PPP2R5B
19
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.1JUND, PLCB3, CDKN1B
20
Show member pathways
9.0PPP2R5B, CDKN1A, CDKN1B, CDKN2C, CDKN2B
21
Show member pathways
9.0CDKN2B, CDKN2C, CDKN1B, CDKN1A, PPP2R5B
22
Show member pathways
8.8GAST, PLCB3, SST
23
Show member pathways
8.6PYGM, PRKAR1A, PLCB3, CDKN1A, CDKN1B, CDKN2B
24
Show member pathways
8.3PPP2R5B, JUND, PLCB3, CDKN1A, CDKN1B
25
Show member pathways
8.2PPP2R5B, PRKAR1A, PLCB3, CDKN1A, CDKN1B, CDKN2C
26
Show member pathways
7.5PPP2R5B, JUND, PRKAR1A, PLCB3, CDKN1A, CDKN1B
27
Show member pathways
6.5SST, PRKAR1A, PPY, PPP2R5B, MEN1, PLCB3

Compounds for genes affiliated with Wermer Syndrome

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Compounds related to Wermer Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide4410.1SST, CHGA
2flavopiridol44 1111.1CDKN1B, PYGM, CDKN1A
3cytarabine44 50 1112.0CDKN1A, CDKN2B, CDKN1B
4p0034410.0CDKN2B, CHGA, CDKN1B
5rpa 2449.9MEN1, JUND
65-hydroxytryptophan449.9SST, CHGA
7mibg449.8CHGA, SST
8azoxymethane449.8CDKN1B, GAST
9pepsinogen449.7CHGA, GAST
10minigastrin449.7GAST, SST
11lafutidine449.7SST, GAST
12loxiglumide449.6GAST, SST
13caffeine44 28 2 50 24 1114.6PYGM, CHGA, SST
14enprostil44 2810.6GAST, SST
15ciglitazone44 2810.6CDKN1B, CDKN1A, GAST
16bethanechol44 28 1111.6GAST, SST
17misoprostol44 1110.6CHGA, GAST
18phorbol449.6JUND, CHGA, CDKN1A
19celecoxib44 61 28 50 24 1114.5CDKN1B, GAST, CDKN1A
20peptidylglycine449.5CHGA, GAST
21pd 98,059449.5JUND, CDKN2B, CDKN1B, CDKN1A
22pantoprazole44 50 24 1112.5GAST, SST
2312-o-tetradecanoylphorbol 13-acetate449.5JUND, CDKN1A, CDKN1B, CHGA
24oxyntomodulin44 6110.4GAST, SST, CHGA
255-hydroxyindoleacetic acid44 2410.4SST, GAST, CHGA
26omeprazole44 50 28 24 1113.4CHGA, SST, GAST
27resveratrol44 61 24 1112.4CDKN1A, GAST, CDKN1B
28octreotide44 61 28 1112.4GAST, SST, CHGA
29c-peptide449.4GAST, SST, CHGA
30propranolol44 28 50 24 1113.3GAST, SST, CHGA
31bromodeoxyuridine449.3CHGA, CDKN1A, GAST, CDKN1B
32arginine449.3CDKN1B, SST, PYGM, PRKAR1A, CHGA
33threonine449.2CDKN1B, CDKN1A, CDKN2C, JUND, CDKN2B
34cycloheximide449.1JUND, CHGA, SST, CDKN1B, CDKN1A
35vitamin d449.0MEN1, PRKAR1A, GAST, CDKN1A, CHGA
36sb 20358044 619.9GAST, CDKN1B, JUND, CDKN1A
37retinoic acid44 249.9JUND, CDKN2B, CHGA, CDKN1B, CDKN1A, SST
38nifedipine44 28 50 1111.9GAST, CHGA, SST
39pge2448.8GAST, CDKN1B, CDKN1A, SST
40carbachol44 28 1110.8GAST, CHGA, JUND, SST
41thymidine44 249.8GAST, JUND, MEN1, CDKN1A, CDKN1B
42vegf448.7CHGA, SST, MEN1, GAST, CDKN1A, CDKN1B
43cisplatin44 50 61 1111.7CDKN1A, JUND, CDKN1B, CHGA, GAST
44glucose448.6CDKN1B, GAST, SST, PRKAR1A, CHGA, PYGM
45estrogen448.3CDKN1B, CDKN2B, CDKN1A, GAST, MEN1, CHGA
46dexamethasone44 50 28 1111.3CDKN1B, CHGA, PRKAR1A, GAST, SST, JUND
47glutamate448.2CHGA, CDKN1B, GAST, SST, PRKAR1A, JUND
48tyrosine448.1CHGA, MEN1, PLCB3, PYGM, CDKN2B, CDKN1B
49dopamine44 28 24 1111.1JUND, GAST, SST, CHGA
50serine448.0MEN1, CHGA, CDKN2B, JUND, CDKN2C, CDKN1B

GO Terms for genes affiliated with Wermer Syndrome

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Cellular components related to Wermer Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.5JUND, PRKAR1A, MEN1, PLCB3, CDKN1B
2nucleolusGO:0057308.1AIP, JUND, MEN1, PLCB3, CDKN1A, CDKN2B
3nucleusGO:0056347.6JUND, MEN1, PLCB3, CDC73, CDKN1A, CDKN1B
4cytosolGO:0058297.4CDKN2B, PPP2R5B, AIP, PYGM, PRKAR1A, MEN1

Biological processes related to Wermer Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:07185010.3CDKN1B, CDKN1A
2negative regulation of protein serine/threonine kinase activityGO:07190110.2CDKN2C, CDKN2B
3cellular response to extracellular stimulusGO:03166810.2CDKN2B, CDKN1A
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.1CDKN1B, CDKN1A, MEN1
5positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0MEN1, CDKN2B
6negative regulation of cell growthGO:03030810.0CDKN1A, CDKN2C, CDKN1B
7negative regulation of G1/S transition of mitotic cell cycleGO:200013410.0CDKN2B, CDC73
8G1/S transition of mitotic cell cycleGO:0000829.9CDKN1B, CDKN2C, CDKN1A
9negative regulation of phosphorylationGO:0423269.8CDKN1A, CDKN2C, CDKN2B, CDKN1B
10regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.8CDKN2B, CDKN2C, CDKN1B, CDKN1A
11osteoblast developmentGO:0020769.8JUND, MEN1
12mitotic cell cycleGO:0002789.7CDKN1A, CDKN1B, CDKN2C, CDKN2B
13epidermal growth factor receptor signaling pathwayGO:0071739.7CDKN1A, PRKAR1A, CDKN1B
14cell cycle arrestGO:0070509.6CDKN1A, CDKN2B, MEN1, CDKN2C, CDKN1B
15response to amino acidGO:0432009.6SST, CDKN1B
16fibroblast growth factor receptor signaling pathwayGO:0085439.6PRKAR1A, CDKN1B, CDKN1A
17negative regulation of cell proliferationGO:0082858.9CDKN2B, SST, CDC73, CDKN1A, CDKN1B, CDKN2C

Molecular functions related to Wermer Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.4CDKN2B, CDKN2C, CDKN1B, CDKN1A
2hormone activityGO:0051798.8PPY, SST, GAST
3protein bindingGO:0055155.7GAST, DNAJC4, MEN1, PRKAR1A, JUND, AIP

Products for genes affiliated with Wermer Syndrome

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  • Antibodies
  • Proteins
  • Lysates

Sources for Wermer Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet