Werner Syndrome malady

NIH Rare Diseases: Werner's syndrome is a disease chiefly characterized by premature aging and cancer predisposition. Development is typically normal until the end of the first decade; the first sign is the lack of a growth spurt during puberty. Early signs (usually in the 20s) include loss and graying of hair, hoarseness, and scleroderma-like skin changes, followed by cataracts, type 2 diabetes mellitus, hypogonadism, skin ulcers, and osteoporosis in the 30s. Myocardial infarction (heart attack) and cancer are the most common causes of death, which typically occurs in the late 40s. It is caused by mutations in the WRN gene and is inherited in an autosomal recessive manner. Management focuses on treatment of signs and symptoms and prevention of secondary complications.³⁰

MalaCards: Werner Syndrome, also known as werner syndrome (disorder), is related to type 2 diabetes mellitus and atypical werner syndrome. An important gene associated with Werner Syndrome is WRN (Werner syndrome, RecQ helicase-like), and among its related pathways are Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks and Telomere Extension by Telomerase. The compounds threonine and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and heart, and related mouse phenotypes are craniofacial and respiratory system.

Genetics Home Reference: Werner syndrome is characterized by the dramatic, rapid appearance of features associated with normal aging. Individuals with this disorder typically grow and develop normally until they reach puberty. Affected teenagers usually do not have a growth spurt, resulting in short stature. The characteristic aged appearance of individuals with Werner syndrome typically begins to develop when they are in their twenties and includes graying and loss of hair; a hoarse voice; and thin, hardened skin. They may also have a facial appearance described as "bird-like." Many people with Werner syndrome have thin arms and legs and a thick trunk due to abnormal fat deposition.¹⁷

Wikipedia: Werner syndrome (WS, also known as \"adult progeria\") is a very rare, autosomal recessive disorder...⁴⁴ more...

OMIM: 277700

GeneReviews summary for werner

Aliases & Descriptions:

werner syndrome 6 7 15 30 17 8 33 32 43 werner syndrome (disorder) 6 16 werner's syndrome 6 30 adult progeria 6 17 ws 6 17

adult premature ageing syndrome 6 adult premature aging syndrome 17 coronary arteriosclerosis 43 coronary artery disease 17 wrn 30

Diseases related to werner syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 556)

id	Related Disease	Score	Top Affiliating Genes
1	type 2 diabetes mellitus	33.4	SERPINE1, LMNA, IRS2, INS, INSR, IL6
2	atypical werner syndrome	32.9	LMNA, INS, WRN
3	myocardial infarction	32.8	SERPINE1, PARP1, ATR, FN1, IRS2, INS
4	arteriosclerosis	32.5	SERPINE1, INS, IL6, APOE, ICAM1, TF
5	polycystic ovary syndrome	31.4	IRS2, INS, INSR, IGFBP3, IGF1
6	hypercholesterolemia	31.2	SERPINE1, ATM, IRS2, INS, INSR, IL6
7	homocysteine	31.2	PCNA, SERPINE1, INS, INSR, IL6, APOE
8	familial combined hyperlipidemia	31.2	SERPINE1, FN1, INS, APOE, TNF, ADIPOQ
9	rothmund-thomson syndrome	31.1	RECQL, RECQL4, RECQL5, BLM, HELLS, TOP3A
10	thrombosis	31.1	PCNA, SERPINE1, BGLAP, FN1, INS, IL6
11	hyperhomocysteinemia	31.0	SERPINE1, INS, IL6, APOE, IGF1, THBD
12	congestive heart failure	30.7	LMNA, FN1, INS, IL6, IGF1, ICAM1
13	familial hypercholesterolemia	30.6	SERPINE1, INS, IL6, APOE, IGF1, GHR
14	systemic lupus erythematosus	30.4	NCL, YBX1, IL6, ICAM1, TNF, RPA1
15	hyperlipidemia	30.4	SERPINE1, FN1, INS, INSR, IL6, APOE
16	acute myocardial infarction	29.9	SERPINE1, PARP1, FN1, INS, IL6, APOE
17	hypertriglyceridemia	29.9	SERPINE1, LMNA, INS, INSR, IL6, APOE
18	progeria	29.3	LMNA, INS, TP53, HELLS, WRN, ADIPOQ
19	essential hypertension	29.2	SERPINE1, BGLAP, MT-TL1, IRS2, INS, INSR
20	hyperinsulinism	29.1	SERPINE1, LMNA, IRS2, INS, INSR, IGFBP3
21	non-hodgkin lymphoma	29.0	NBN, MYC, MSH2, ATM, INSR, CASP7
22	vulvar cancer	28.8	IL6, MAPK1, TP53, HELLS, WRN
23	coronary stenosis	28.8	SERPINE1, IL6, APOE, ICAM1, ADIPOQ
24	megakaryoblastic leukemia	28.7	UBE2I, IL6, TNF, SUMO1, TAGLN, PML
25	was-related disorders	28.6	VCP, ATM, INS, IL6, APOE, IGF1
26	coronary artery anomaly	28.6	SERPINE1, LMNA, FN1, INS, INSR, IL6
27	periodontal disease	28.5	BGLAP, FN1, INS, IL6, MAPK1, ICAM1
28	blindness	28.4	SERPINE1, BGLAP, INS, IL6, APOE, MAPK14
29	vascular disease	28.3	SERPINE1, PARP1, INS, APOE, MAPK1, ICAM1
30	hypertension	28.2	PCNA, SERPINE1, LMNA, BGLAP, MT-TL1, ATR
31	colorectal cancer	28.1	XRCC5, MSH2, MLH1, APOE, TP53, TNF
32	hyperandrogenism	28.0	LMNA, IRS2, INS, INSR, IL6, IGFBP3
33	peripheral vascular disease	28.0	SERPINE1, INS, IL6, ICAM1, TP53, THBD
34	chronic myeloid leukemia	27.8	MYC, FN1, MAPK14, MAPK1, ABL1, POLB
35	nijmegen breakage syndrome	27.8	NBN, BRCA1, RAD51, RAD52, RAD50, RAD54B
36	b-cell lymphomas	27.7	NBN, MYC, PARP1, ATM, MAPK14, CCNT1
37	retinol binding protein	27.7	MYC, INS, INSR, MAPK1, TNF, TF
38	obesity	27.7	PCNA, SERPINE1, LMNA, BGLAP, IRS2, INS
39	pneumonia	27.6	REV1, SERPINE1, RAD51, RAD54L, RAD54B, BGLAP
40	proteinuria	27.6	SERPINE1, FN1, INS, APOE, MAPK14, ICAM1
41	age related macular degeneration	27.6	SERPINE1, PARP1, IL6, APOE, MAPK1, IGF1
42	cerebrovascular disease	27.4	SERPINE1, INS, IL6, APOE, ICAM1, TNF
43	periodontitis	27.4	SERPINE1, BGLAP, FN1, INS, IL6, APOE
44	cytomegalovirus infection	27.3	IL6, APOE, MAPK14, CCNT1, ICAM1, TNF
45	aldosteronism	27.3	SERPINE1, FN1, IRS2, INS, INSR, IL6
46	atrial fibrillation	27.3	PCNA, SERPINE1, LMNA, INS, IL6, APOE
47	cataract	27.1	RECQL4, PCNA, LMNA, PARP1, FN1, INS
48	ischemia	26.8	PCNA, SERPINE1, MYC, PARP1, UBE2I, MSH2
49	gout	26.7	KAT2B, INS, INSR, IL6, APOE, MAPK14
50	follicular lymphoma	26.5	NBN, BRCA1, MYC, MSH2, MLH1, MAPK14

Clinical features from OMIM: 277700

Approved drugs:

Drug clinical trials:

Genetic tests related to werner syndrome:

id	Genetic test	Affiliating Genes
1	Werner Syndrome clinical/research	WRN

MalaCards organs/tissues related to werner syndrome:

²²

MGI Mouse Phenotypes related to werner syndrome:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.1	POLH, ATR, YBX1, NBN, RECQL4, SIRT1
2	respiratory system phenotype	MP:0005388	9.9	SIRT1, POLB, APOE, FEN1, INSR, ATR
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	WRN, CSDA, H2AFX, GHR, EXO1, CDC42
4	limbs/digits/tail phenotype	MP:0005371	9.2	WRN, SIRT1, HELLS, GHR, APOE, FN1
5	renal/urinary system phenotype	MP:0005367	9.1	HELLS, DNASE1, TAGLN, PRKDC, POLB, NEIL1
6	liver/biliary system phenotype	MP:0005370	8.4	RAD50, YBX1, ATR, INS, FEN1, IL6
7	no phenotypic analysis	MP:0003012	8.3	TP53, PPP2CB, POT1, POLH, PML, SIRT1
8	pigmentation phenotype	MP:0001186	8.3	TP53, HELLS, PRKDC, POLH, EFEMP1, ANK1
9	embryogenesis phenotype	MP:0005380	8.2	PARP1, PARP2, CHAF1A, UBE2I, YBX1, ATRX
10	normal phenotype	MP:0002873	8.1	SUMO1, PPP2CB, ABL1, THBD, TAGLN, POU5F1
11	hematopoietic system phenotype	MP:0005397	8.0	PCNA, NBN, BRCA1, RAD52, RAD50, RAD54L
12	reproductive system phenotype	MP:0005389	7.6	RAD18, PARP2, XRCC5, XRCC6, ATRX, ATR
13	integument phenotype	MP:0010771	7.4	YBX1, MSH2, MSH3, MSH6, ATR, MLH1
14	skeleton phenotype	MP:0005390	7.3	ANK1, MAPK14, IGF1, TP53, ABL1, HELLS
15	behavior/neurological phenotype	MP:0005386	7.2	IL6, APOE, ANK1, MAPK1, GHR, ABL1
16	vision/eye phenotype	MP:0005391	7.0	TP53, TNF, ABL1, H2AFX, PRKDC, SIRT1
17	digestive/alimentary phenotype	MP:0005381	6.4	SUMO1, TNF, TP53, TREX1, ERCC5, ABL1
18	adipose tissue phenotype	MP:0005375	6.4	APOE, IGFBP3, IGF1, GHR, TP53, TNF
19	immune system phenotype	MP:0005387	5.8	MRE11A, TAGLN, PRKDC, POLB, POLD1, POLH
20	muscle phenotype	MP:0005369	4.8	IGF1, ICAM1, TREX1, TP53, TNF, PLRG1
21	growth/size phenotype	MP:0005378	4.5	TP53, ADIPOQ, EFEMP1, ABL1, H2AFX, HELLS
22	tumorigenesis	MP:0002006	4.5	MAPK14, WRN, ADIPOQ, SIRT1, NEIL1, IGF1
23	mortality/aging	MP:0010768	3.9	EFEMP1, WRN, RECQL4, MSH3, MSH6, ATRX
24	nervous system phenotype	MP:0003631	3.5	GHR, CASP7, ICAM1, IGF1, MAPK1, MAPK14
25	cardiovascular system phenotype	MP:0005385	3.5	PLRG1, TNF, TP53, TREX1, GHR, CASP7
26	homeostasis/metabolism phenotype	MP:0005376	2.7	TF, DNASE1, PRKDC, POLB, SLC20A1, NEIL1
27	cellular phenotype	MP:0005384	1.7	RAD54B, BLM, PARP1, PARP2, CHAF1A, UBE2I

Articles related to werner syndrome:

(show top 50)    (show all 196)

id	Title	Authors	Year	Affiliating Genes
1	Biguanide, but not thiazolidinedione, improved insuli n resistance in Werner syndrome. (20122053)	Yasuda H.... Yokono K.	2010	INS
2	Expression profiling of mouse embryonic fibroblasts w ith a deletion in the helicase domain of the Werner Syndrome gene homologue tre ated with hydrogen peroxide. (20175907)	LabbAc A.... Lebel M.	2010	WRN, HELLS
3	Werner syndrome as a hereditary risk factor for exocr ine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and pa tient-tailored therapy. (20657174)	Chun S.G.... Yee N.S.	2010	WRN
4	The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation. (19283071)	Opresko P.L.... Wang H.	2009	WRN
5	WRN helicase defective in the premature aging disorde r Werner syndrome genetically interacts with topoisomerase 3 and restores the t op3 slow growth phenotype of sgs1 top3. (20157511)	Aggarwal M.... Brosh R.M.	2009	WRN
6	Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTER T gene. (19398855)	Ariyoshi K.... Kodama S.	2009	WRN
7	Novel LMNA mutation in atypical Werner syndrome presenting with ischemic disease. (19095983)	Renard D.... De Sandre-Giovannoli A.	2009	LMNA
8	A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. (19205873)	Wang Z.... Shen H.	2009	BLM, BRCA1, WRN
9	Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases. (18054793)	Opresko P.L.	2008	WRN
10	The transcriptional response to distinct growth factors is impaired in Werner syndrome cells. (18625297)	Lutomska A.... Iben S.	2008	WRN, POLR1C
11	Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase. (18583366)	Sowd G.... Opresko P.L.	2008	WRN
12	The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. (18596042)	Compton S.A.... Griffith J.D.	2008	WRN
13	Werner syndrome helicase activity is essential in maintaining fragile site stability. (18209099)	Pirzio L.M.... Franchitto A.	2008	WRN
14	Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein. (17229737)	Choi J.M.... Cho Y.	2007	WRN
15	Werner syndrome protein interacts functionally with translesion DNA polymerases. (17563354)	Kamath-Loeb A.S.... Loeb L.A.	2007	WRN, POLH
16	Werner's syndrome (adult onset progeria) (17375009)	Kluger N.... Aractingi S.	2007	WRN
17	Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. (17717003)	Machwe A.... Orren D.K.	2007	WRN
18	Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease. (18056975)	Cox L.S.... Saunders R.D.	2007	WRN
19	The spectrum of WRN mutations in Werner syndrome patients. (16673358)	Huang S.... Oshima J.	2006	WRN
20	Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. (16720342)	Orren D.K.	2006	WRN
21	Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A. (16380375)	Choudhary S.... Brosh R.M.	2006	WRN, HELLS
22	A novel compound heterozygous mutation in Werner syndrome results in WRN transcript decay. (15888165)	Muller F.B.... Hunzelmann N.	2005	WRN
23	Pathways and functions of the Werner syndrome protein. (15610765)	Lee J.W.... Bohr V.A.	2005	WRN
24	Deficient DNA repair in the human progeroid disorder, Werner syndrome. (15916783)	Bohr V.A.	2005	WRN
25	Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients. (15246744)	Bohr V.A.... Seidman M.M.	2004	WRN
26	The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. (15489508)	Kamath-Loeb A.S.... Loeb L.A.	2004	WRN, HELLS
27	Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion. (15037256)	Indig F.E.... Bohr V.A.	2004	VCP, WRN, DNAH8
28	Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. (14734561)	Li B.... Comai L.	2004	PARP1, XRCC6, WRN
29	Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery. (15467456)	Franchitto A.... Pichierri P.	2004	WRN
30	In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. (15282207)	Sharma S.... Brosh R.M.	2004	FEN1, WRN
31	The Werner syndrome protein has separable recombination and survival functions. (15084309)	Swanson C.... Monnat R.J.	2004	WRN, HELLS
32	Werner syndrome protein limits MYC-induced cellular senescence. (12842909)	Grandori C.... Monnat R.J.	2003	MYC, WRN
33	LMNA mutations in atypical Werner's syndrome. (14615129)	Bonne G.... Levy N.	2003	LMNA
34	Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent. (12881525)	Driscoll H.C.... Brosh R.M.	2003	HELLS
35	The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl- terminal region of the Werner syndrome protein. (12704184)	Sharma S.... Brosh R.M. Jr.	2003	WRN, EXO1
36	WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. (12934712)	Chen L.... Oshima J.	2003	WRN
37	LMNA mutations in atypical Werner's syndrome. (14615128)	Vigouroux C.... Cohen A.	2003	LMNA
38	Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication. (11275547)	Enomoto T.	2001	BLM, WRN
39	Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. (11735402)	Li J.L.... Hickson I.D.	2001	HELLS
40	The role of Werner's syndrome gene in the genetic susceptibility to the type 2 diabetes in Chinese population (11798788)	Luo Y.... Han X.	2000	WRN
41	Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. (11256630)	Constantinou A.... West S.C.	2000	BLM, WRN, CSDA
42	WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. (10811112)	Hisama F.M.... Weissman S.M.	2000	WRN, POLD2
43	Werner syndrome (10921329)	Goto M.... Ishikawa Y.	2000	HELLS
44	Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1. (10806190)	Kawabe Y.... Enomoto T.	2000	UBE2I, WRN, SUMO1
45	The Werner syndrome protein is involved in RNA polyme rase II transcription. (10436020)	Balajee A.S.... Bohr V.A.	1999	POLR2L
46	In vivo somatic mutations in Werner's syndrome. (9856481)	Kyoizumi S.... Goto M.	1998	GYPA
47	Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. (9012406)	Yu C.E.... Schellenberg G.D.	1997	HELLS
48	SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. (8913739)	Watt P.M.... Louis E.J.	1996	WRN
49	Autophosphorylation of insulin receptor in a patient with Werner's syndrome associated with insulin resistant diabetes mellitus. (7599691)	Shima F.... Kazumi T.	1995	INSR, INS
50	Genetic linkage of Werner's syndrome to five markers on chromosome 8. (1741060)	Goto M.... Drayna D.	1992	WRN

Genes related to werner syndrome according to GeneCards:

(show top 50)    (show all 102)

id	Symbol	Description	Score	GeneCards Section Context
1	WRN	Werner syndrome, RecQ helicase-like	11.1	Orthologs, Transcripts, Databases, Publications (show all 6 sections) Aliases & Descriptions, Summaries
2	WRNIP1	Werner helicase interacting protein 1	11.1	Summaries, Publications
3	PURG	purine-rich element binding protein G	11.1	Summaries
4	LMNA	lamin A/C	11.0	Publications
5	RECQL	RecQ protein-like (DNA helicase Q1-like)	11.0	Orthologs, Publications
6	HELLS	helicase, lymphoid-specific	11.0	Publications
7	RECQL4	RecQ protein-like 4	11.0	Publications
8	RECQL5	RecQ protein-like 5	11.0	Disorders, Publications
9	TREX1	three prime repair exonuclease 1	11.0
10	BLM	Bloom syndrome, RecQ helicase-like	11.0	Publications, Orthologs
11	POLB	polymerase (DNA directed), beta	11.0	Publications
12	TERF2	telomeric repeat binding factor 2	11.0	Publications
13	RAD54L	RAD54-like (S. cerevisiae)	11.0
14	EXO1	exonuclease 1	11.0	Publications
15	FEN1	flap structure-specific endonuclease 1	11.0	Publications
16	GYPA	glycophorin A (MNS blood group)	11.0	Publications
17	VCP	valosin containing protein	11.0	Publications
18	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	11.0
19	RPA1	replication protein A1, 70kDa	11.0	Publications
20	NBN	nibrin	11.0	Publications
21	MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	11.0	Publications
22	POLR1C	polymerase (RNA) I polypeptide C, 30kDa	11.0	Publications
23	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	11.0	Publications
24	POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	11.0	Publications
25	DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	11.0	Publications
26	DNASE1	deoxyribonuclease I	11.0	Publications
27	INSR	insulin receptor	11.0	Publications
28	PARP1	poly (ADP-ribose) polymerase 1	11.0	Publications
29	DNAH8	dynein, axonemal, heavy chain 8	11.0	Publications
30	TOP1	topoisomerase (DNA) I	11.0	Publications
31	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
32	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
33	BRCA1	breast cancer 1, early onset	11.0	Publications
34	INS	insulin	11.0	Publications
35	ATM	ataxia telangiectasia mutated	11.0
36	MT-TL1	mitochondrially encoded tRNA leucine 1 (UUA/G)	11.0	Publications
37	POLD2	polymerase (DNA directed), delta 2, accessory subunit	11.0	Publications
38	NEIL1	nei endonuclease VIII-like 1 (E. coli)	11.0	Publications
39	TAGLN	transgelin	11.0	Functions, Publications
40	PARP2	poly (ADP-ribose) polymerase 2	11.0	Publications
41	HBD	hemoglobin, delta	11.0	Publications
42	SLC20A1	solute carrier family 20 (phosphate transporter), member 1	11.0	Publications
43	CHAF1B	chromatin assembly factor 1, subunit B (p60)	11.0	Publications
44	RAD52	RAD52 homolog (S. cerevisiae)	11.0	Publications
45	CHAF1A	chromatin assembly factor 1, subunit A (p150)	11.0	Publications
46	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Publications
47	POLH	polymerase (DNA directed), eta	11.0	Publications
48	GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa	11.0	Publications
49	KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	11.0	Publications
50	H2AFX	H2A histone family, member X	11.0	Publications

Pathways related to werner syndrome according to GeneDecks:

(show top 50)    (show all 72)

id	Pathway	Score	Top Affiliating Genes
1	Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks38	10.6	NBN, RAD50, MRE11A, H2AFX
2	Telomere Extension by Telomerase36	10.5	POT1, TERF2, MRE11A, XRCC5, RAD50
3	Aldosterone-regulated sodium reabsorption20	10.5	IRS2, INS
4	Fanconis Anaemia Pathway36	10.4	MRE11A, ATM, ATR, RAD50, RAD51, BRCA1
5	Adipocytokines & Insulin Signaling37	10.4	ADIPOQ, INSR, INS, IRS2
6	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.3	ATM, ATR, BLM, MYC, NBN
7	Type II diabetes mellitus20	10.3	ADIPOQ, INS, IRS2
8	Non-homologous end-joining20	10.3	PRKDC, FEN1, MRE11A, XRCC6, XRCC5, RAD50
9	DNA damage NHEJ mechanisms of DSBs repair10	10.2	MRE11A, FEN1, PRKDC, SIRT1, WRN, XRCC6
10	DNA damage_NHEJ mechanisms of DSBs repair41	10.2	NBN, BRCA1, RAD50, XRCC5, XRCC6, MRE11A
11	Colorectal cancer20	10.2	MSH6, MSH3, MSH2
12	Meiosis10	10.1	TOP3A, BLM, RAD54B, RAD54L, RAD52, RAD51
13	Cell cycle_Transition and termination of DNA replication41	10.0	BRCA1, FEN1, TOP1, POLD2, POLD1, WRN
14	Cell cycle Transition and termination of DNA replacation10	10.0	WRN, POLD1, POLD2, TOP1, FEN1, BRCA1
15	Base excision repair20	10.0	NEIL1, POLD1, POLB, POLD2, FEN1, PARP2
16	DNA replication20	9.9	POLD1, POLD2, DNA2, RPA1, FEN1, PCNA
17	Homologous recombination20	9.8	NBN, RAD51, RAD52, RAD50, RAD54L, RAD54B
18	Transcription_Receptor-mediated HIF regulation41	9.7	INS, INSR, MAPK1, IGFBP3, IGF1, IRS2
19	Transcription Receptor-mediated HIF regulation10	9.7	IGF1, IGFBP3, MAPK1, INSR, INS, IRS2
20	DNA Damage Induced 14-3-3Sigma Signaling36	9.6	TP53, ATM, ATR, BRCA1
21	Apoptosis and survival_Caspase cascade41	9.5	TNF, CASP7, IGF1, PARP1, LMNA
22	Mismatch Repair in Eukaryotes36	9.5	POLD1, EXO1, FEN1, MLH1, MSH6, MSH3
23	Apoptosis and survival Caspase cascade10	9.5	TNF, CASP7, IGF1, PARP1, LMNA
24	GADD45 Pathway36	9.5	TP53, CCNT1, ATM, ATR, BRCA1, PCNA
25	Mismatch repair20	9.5	POLD1, POLD2, RPA1, EXO1, MLH1, MSH6
26	p53 Signaling36	9.5	SIRT1, PML, ABL1, TP53, ATM, ATR
27	Chks in Checkpoint Regulation36	9.4	TP53, MRE11A, ATM, ATR, RAD50, BRCA1
28	DNA damage_DNA-damage-induced responses41	9.4	ATR, ATM, TP53, ABL1, PRKDC, BRCA1
29	DNA damage DNA-damage-induced responses10	9.4	PRKDC, ABL1, TP53, ATM, ATR, BRCA1
30	DNA damage Role of SUMO in p53 regulation10	9.4	PML, SUMO1, TP53, UBE2I
31	Nucleotide excision repair20	9.3	POLD1, POLD2, RPA1, ERCC5, PCNA
32	DNA damage_Role of SUMO in p53 regulation41	9.3	UBE2I, TP53, SUMO1, PML
33	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.3	TP53, ATM, ATR, BLM, MYC, BRCA1
34	BRCA1 Pathway36	9.2	HELLS, TP53, MRE11A, ATM, ATR, MSH6
35	Inhibition of Ribosome Biogenesis by p14(ARF)36	9.2	POLR1C, ABL1, TP53, MYC
36	p53 signaling pathway20	9.1	TP53, IGF1, IGFBP3, ATM, ATR, SERPINE1
37	ATM Pathway36	8.9	H2AFX, ABL1, TP53, MAPK14, MRE11A, ATM
38	DNA Damage3	8.8	PRKDC, WRN, RPA1, NBN, BRCA1, VCP
39	DNA damage_Role of Brca1 and Brca2 in DNA repair41	8.7	PCNA, NBN, BRCA1, RAD51, RAD50, MSH2
40	DNA damage Role of Brca1 and Brca2 in DNA repair10	8.7	POLR2L, POLB, H2AFX, PCNA, NBN, BRCA1
41	Cell cycle20	8.7	PRKDC, ABL1, TP53, ATM, ATR, MYC
42	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.6	TNF, IGF1, APOE, IL6, BGLAP
43	Telomerase Components in Cell Signaling36	8.4	POT1, ABL1, TERF2, TP53, IGF1, IL6
44	Cell Cycle / Checkpoint Control3	8.3	RECQL4, MRE11A, MLH1, FEN1, TP53, TERF2
45	SUMO Pathway36	8.2	SIRT1, TNF, TP53, MAPK1, MAPK14, UBE2I
46	Pathways in cancer20	8.1	PML, ABL1, TP53, MAPK1, CDC42, MSH6
47	Molecular Mechanisms of Cancer36	8.0	EFEMP1, PRKDC, ABL1, TP53, MAPK1, IL6
48	ILK Signaling36	7.7	EFEMP1, PPP2CB, TNF, IGF1, MAPK1, IL6
49	Colorectal Cancer Metastasis36	7.6	TNF, TP53, MAPK1, IL6, MLH1, MSH6
50	DNA Repair Mechanisms36	6.9	PCNA, BRCA1, RAD51, RAD50, XRCC5, MSH2

Compounds related to werner syndrome according to GeneDecks:

(show top 50)    (show all 226)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.3	NBN, HELLS, MSH6, CDC42, XRCC5
2	8-oxoguanine32	10.2	PCNA, BRCA1, HELLS, POLR2L, WRN, POLB
3	mitomycin c32	10.2	POLB, TOP1, H2AFX, MRE11A, ATM, XRCC6
4	melphalan32 9 9	12.0	RAD51, XRCC5, TOP1, POLB
5	mononucleotide32	9.9	MLH1, MRE11A, MSH6, MSH3, MSH2, RAD50
6	roscovitine32	9.9	MAPK14, POLR2L, H2AFX, PARP1, CCNT1, PCNA
7	adenine32 9 18 9	12.6	MLH1, BRCA1, HELLS, RAD51, POLR2L, POLH
8	n acetylcysteine32	9.4	PCNA, ATM, APOE, H2AFX, TP53, DNASE1
9	bleomycin32 9 9	11.3	DNASE1, ATM, H2AFX, XRCC5, TOP1, TP53
10	thymidylate32	9.3	PCNA, RAD51, MSH2, MLH1, BRCA1, TP53
11	cysteine32	9.2	FN1, WRN, UBE2I, BGLAP, PML, PCNA
12	topotecan32 9 9	11.2	CASP7, BRCA1, UBE2I, TP53, H2AFX, TOP1
13	aphidicolin32	9.1	RAD51, MYC, BRCA1, PCNA, ATM, DNASE1
14	etoposide32 42 9 9	12.0	MLH1, CASP7, TP53, RPA1, H2AFX, TOP1
15	h2o232	8.9	RECQL4, BRCA1, RAD51, BGLAP, KCNA2, INSR
16	hydroxyurea32 9 9	10.7	BLM, RAD50, RAD51, MYC, BRCA1, NBN
17	cyclosporin a32 42	9.7	BGLAP, APOE, ICAM1, CASP7, THBD, TF
18	atp32	8.6	YBX1, MSH2, ATRX, ATM, CDC42, MLH1
19	glutamine32	8.6	HELLS, TOP1, SUMO1, BRCA1, DNAH8, DNASE1
20	arginine32	8.6	FN1, GYPA, INS, FEN1, APOE, CCNT1
21	creatinine32	8.6	THBD, GHR, IGF1, LMNA, PCNA, FN1
22	thyroxine32 18	9.5	IGF1, ADIPOQ, DNAH8, TF, THBD, PCNA
23	8-isoprostane32	8.5	INS, TF, SERPINE1, ADIPOQ, IL6, THBD
24	bortezomib32 9 9	10.4	MYC, BRCA1, MAPK14, TOP1, H2AFX, TP53
25	methylmethanesulfonate32	8.4	XRCC6, TOP3A, RPA1, TP53, MAPK14, FEN1
26	sb 20358032 42	9.2	KCNA2, PARP1, INSR, ADIPOQ, TNF, IGF1
27	mg 13232 42	9.2	PCNA, BRCA1, MYC, PARP1, MAPK1, ICAM1
28	ly29400232	8.1	CDC42, FN1, IRS2, IL6, MAPK14, MAPK1
29	oligonucleotide32	7.9	ERCC5, TREX1, TP53, TERF2, RPA1, ABL1
30	adpribose32	7.9	TERF2, POLB, TNF, PCNA, BRCA1, PARP1
31	ciglitazone32	7.9	ICAM1, MAPK1, MAPK14, APOE, IL6, TNF
32	arsenite32 18	8.9	POLR2L, TP53, KCNA2, PARP1, MYC, PCNA
33	rosiglitazone32 9 18 9	10.8	INSR, INS, IRS2, LMNA, SERPINE1, TNF
34	doxorubicin32 34 9 9	10.8	ATM, MSH2, MSH3, MSH6, MLH1, FN1
35	paclitaxel32 34 9 9	10.7	MAPK1, MAPK14, MLH1, YBX1, PARP1, RAD51
36	troglitazone32 42 9 9	10.7	TNF, MAPK14, ADIPOQ, ICAM1, MAPK1, IL6
37	estrogen32	7.6	NCL, IGF1, GHR, SUMO1, THBD, TF
38	camptothecin32 42 9 9	10.6	WRN, XRCC6, XRCC5, YBX1, PARP1, BLM
39	lactacystin32	7.2	TNF, TP53, GHR, MAPK1, MAPK14, MYC
40	alanine32	7.1	MYC, APOE, IGFBP3, GHR, HELLS, THBD
41	curcumin32	7.0	XRCC6, PARP1, KAT2B, IL6, MAPK14, MAPK1
42	phosphatidylinositol32	6.9	ABL1, H2AFX, TAGLN, PRKDC, ATR, CDC42
43	genistein32 9 18 9	9.9	ATR, ATM, CDC42, PARP1, TNF, PCNA
44	cisplatin32 34 9 9	9.4	BGLAP, ERCC5, TP53, RPA1, ABL1, H2AFX
45	dexamethasone32 42 34 9 9	10.0	ADIPOQ, INSR, INS, IRS2, PARP1, BGLAP
46	actinomycin d32	5.7	TOP1, THBD, DNASE1, DHX9, POLR1C, POLR2L
47	cycloheximide32	5.5	ICAM1, IGF1, IGFBP3, MAPK1, APOE, CASP7
48	vegf32	4.6	THBD, TF, CSDA, POLR2L, POU5F1, ABL1
49	retinoic acid32 42 18	6.3	MYC, GHR, TP53, TNF, TERF2, SUMO1
50	serine32	3.8	IGF1, RAD50, BGLAP, KCNA2, YBX1, XRCC5

Cellular components related to werner syndrome according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	Mre11 complex	GO:030870	10.5	TERF2, MRE11A, RAD50, NBN
2	chromosome, telomeric region	GO:000781	10.5	POT1, H2AFX, TERF2, MRE11A, ATM, BLM
3	nuclear telomere cap complex	GO:000783	10.4	POT1, TERF2, XRCC6, XRCC5
4	replication fork	GO:005657	10.4	NBN, RAD18, BLM, H2AFX
5	male germ cell nucleus	GO:001673	10.4	BLM, RPA1, H2AFX
6	condensed nuclear chromosome	GO:000794	10.4	H2AFX, RPA1, MRE11A, RAD51
7	nonhomologous end joining complex	GO:070419	10.3	PRKDC, XRCC6, XRCC5
8	DNA-dependent protein kinase-DNA ligase 4 complex	GO:005958	10.2	PRKDC, XRCC6, XRCC5
9	chromatin assembly complex	GO:005678	9.2	CHAF1A, CHAF1B, TP53
10	PML body	GO:016605	9.2	SIRT1, PML, TOP3A, RPA1, SUMO1, TP53
11	nucleolus	GO:005730	8.1	TOP1, ABL1, RPA1, TERF2, TP53, DHX9
12	extracellular space	GO:005615	7.2	ADIPOQ, EFEMP1, THBD, TNF, GHR, ICAM1
13	cytoplasm	GO:005737	6.3	DNAH8, ABL1, RPA1, DDX19B, SUMO1, TERF2
14	nucleoplasm	GO:005654	5.3	RAD51, RAD52, RAD50, PARP1, PARP2, CHAF1B
15	nucleus	GO:005634	4.4	POLH, POLR2L, POU5F1, PML, NEIL1, SIRT1

Biological processes related to werner syndrome according to GeneDecks:

(show top 50)    (show all 68)

id	Name	GO ID	Score	Top Affiliating Genes
1	meiosis	GO:007126	10.6	TOP3A, H2AFX, RPA1, EXO1, RAD54L, RAD51
2	DNA strand renaturation	GO:000733	10.6	RAD54L, RECQL4, RECQL
3	positive regulation of protein autophosphorylation	GO:031954	10.6	INS, MRE11A, RAD50, NBN
4	telomere maintenance via telomerase	GO:007004	10.5	RAD50, MRE11A, TERF2, POT1
5	DNA recombinase assembly	GO:000730	10.5	RPA1, RAD52, RAD51
6	mitotic recombination	GO:006312	10.5	RAD54B, RAD52, RAD51
7	positive regulation of kinase activity	GO:033674	10.5	MRE11A, RAD50, NBN
8	reciprocal meiotic recombination	GO:007131	10.5	MRE11A, ATM, RAD54B, RAD50, RAD52, RAD51
9	DNA recombination	GO:006310	10.4	RECQL, RECQL4, RECQL5, RAD51, RAD50, RAD54L
10	response to ionizing radiation	GO:010212	10.4	H2AFX, ICAM1, ATM, XRCC6, RAD54L, BRCA1
11	double-strand break repair via nonhomologous end joining	GO:006303	10.4	PRKDC, MRE11A, XRCC6, XRCC5
12	double-strand break repair via homologous recombination	GO:000724	10.3	NBN, BRCA1, RAD51, RAD52, RAD50, RAD54L
13	DNA duplex unwinding	GO:032508	10.3	RECQL, RECQL4, RECQL5, NBN, RAD50, RAD54B
14	DNA damage response, signal transduction resulting in induction of apoptosis	GO:008630	10.3	PML, ABL1, ATM, MSH6, BRCA1
15	regulation of glucose metabolic process	GO:010906	10.2	ADIPOQ, SIRT1, IGFBP3
16	DNA synthesis involved in DNA repair	GO:000731	10.2	WRNIP1, WRN, SIRT1, POLH, POLD1
17	positive regulation of helicase activity	GO:051096	10.2	POT1, MSH6, MSH3, MSH2
18	positive regulation of glycogen biosynthetic process	GO:045725	10.2	IRS2, INS, INSR, IGF1
19	postreplication repair	GO:006301	10.2	POLH, MSH2, BRCA1
20	negative regulation of DNA recombination	GO:045910	10.1	MSH6, MSH3, MSH2, BLM, RAD18
21	maintenance of DNA repeat elements	GO:043570	10.1	MSH6, MSH3, MSH2
22	positive regulation of DNA replication	GO:045740	10.1	DNA2, IGF1, INSR, INS, CDC42
23	nucleotide-excision repair, DNA gap filling	GO:006297	10.1	POLD1, POLB, POLD2, RPA1, PCNA
24	telomere maintenance via semi-conservative replication	GO:032201	10.0	POLD1, POLD2, DNA2, RPA1, FEN1, PCNA
25	telomere maintenance via recombination	GO:000722	10.0	POLD1, POLD2, DNA2, RPA1, FEN1, PCNA
26	DNA strand elongation involved in DNA replication	GO:006271	10.0	POLD1, POLD2, DNA2, RPA1, FEN1, PCNA
27	transcription-coupled nucleotide-excision repair	GO:006283	10.0	POLR2L, POLD1, POLD2, RPA1, ERCC5, PCNA
28	positive regulation of glucose import	GO:046326	10.0	ADIPOQ, IGF1, INSR, INS, IRS2
29	mismatch repair	GO:006298	9.9	ABL1, TREX1, EXO1, MSH6, MSH3, MSH2
30	cellular response to insulin stimulus	GO:032869	9.7	ADIPOQ, PRKDC, GHR, INSR, IRS2, KAT2B
31	positive regulation of MAPK cascade	GO:043410	9.6	IGF1, IGFBP3, IL6, INSR, INS
32	response to UV	GO:009411	9.6	PML, POLD1, ERCC5, CASP7, MSH6, RAD18
33	determination of adult lifespan	GO:008340	9.5	TP53, ERCC5, MSH6, MSH2
34	DNA damage checkpoint	GO:000077	9.5	H2AFX, MAPK14, ATR, NBN
35	cell aging	GO:007569	9.5	ICAM1, TP53, PML, SIRT1, WRN, BGLAP
36	telomere maintenance	GO:000723	9.4	DNA2, PRKDC, POLD2, POT1, POLD1, WRN
37	double-strand break repair	GO:006302	9.2	RPA1, H2AFX, PRKDC, TP53, FEN1, NBN
38	DNA replication	GO:006260	9.2	POLD1, POLH, SIRT1, WRN, WRNIP1, POLD2
39	response to DNA damage stimulus	GO:006974	9.2	WRN, SIRT1, POLB, H2AFX, TP53, MRE11A
40	nucleotide-excision repair	GO:006289	9.2	NEIL1, POLR2L, POLD1, POLD2, RPA1, TP53
41	base-excision repair	GO:006284	9.1	POLD2, POLB, POLD1, NEIL1, WRN, DNA2
42	negative regulation of fat cell differentiation	GO:045599	9.1	SIRT1, TNF, IL6, ADIPOQ
43	cell cycle arrest	GO:007050	8.9	PML, TP53, KAT2B, ATM, MSH2, MYC
44	response to glucocorticoid stimulus	GO:051384	8.9	ADIPOQ, TNF, GHR, IL6, INSR, BGLAP
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.6	ADIPOQ, TP53, GHR, IGF1, IL6, INS
46	negative regulation of transcription, DNA-dependent	GO:045892	8.4	ADIPOQ, SIRT1, PML, SUMO1, TNF, TP53
47	negative regulation of apoptotic process	GO:043066	8.1	SIRT1, CSDA, PPP2CB, TNF, TP53, ERCC5
48	DNA repair	GO:006281	7.6	RECQL, XRCC5, XRCC6, MSH2, MSH3, MSH6
49	blood coagulation	GO:007596	7.1	TF, THBD, HBD, ABL1, TP53, IGF1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	IGF1, TP53, TNF, PRKDC, POU5F1, SIRT1

Molecular functions related to werner syndrome according to GeneDecks:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP-dependent 3-5 DNA helicase activity	GO:043140	10.8	WRN, BLM, RECQL4, RECQL
2	bubble DNA binding	GO:000405	10.7	WRN, ERCC5, BLM, RECQL4
3	ATP-dependent DNA helicase activity	GO:004003	10.5	WRN, DHX9, MRE11A, XRCC6, XRCC5, BLM
4	DNA helicase activity	GO:003678	10.5	WRN, DNA2, ATRX, RAD54B, RECQL5, RECQL
5	3-5 exonuclease activity	GO:008408	10.5	WRN, TREX1, EXD3, MRE11A, RAD50
6	helicase activity	GO:004386	10.5	WRN, DNA2, HELLS, DDX19B, ATRX, BLM
7	telomeric DNA binding	GO:042162	10.3	NCL, XRCC5, TERF2
8	MutSalpha complex binding	GO:032407	10.3	TREX1, MLH1, ATR
9	damaged DNA binding	GO:003684	10.3	NEIL1, POLH, POLB, H2AFX, FEN1, RAD18
10	double-stranded telomeric DNA binding	GO:003691	10.3	TERF2, XRCC6, XRCC5
11	ATPase activity	GO:016887	10.2	WRNIP1, WRN, DNAH8, DNA2, MSH6, MSH2
12	mismatched DNA binding	GO:030983	10.1	MLH1, MSH6, MSH3, MSH2
13	MutLalpha complex binding	GO:032405	10.1	TREX1, ATR, MSH6, MSH2, PCNA
14	single guanine insertion binding	GO:032142	10.1	MSH3, MSH6, MSH2
15	oxidized purine DNA binding	GO:032357	10.1	MSH2, MSH3, MSH6
16	single-stranded DNA binding	GO:003697	10.0	CSDA, RPA1, TREX1, ERCC5, MLH1, MSH3
17	DNA-directed DNA polymerase activity	GO:003887	10.0	POLH, POLD1, POLB, POLD2, REV1
18	dinucleotide insertion or deletion binding	GO:032139	10.0	MSH3, PCNA, MSH2
19	guanine/thymine mispair binding	GO:032137	10.0	MSH2, MSH3, MSH6
20	double-stranded DNA binding	GO:003690	9.6	MRE11A, FEN1, ERCC5, TREX1, CSDA, MSH6
21	protein C-terminus binding	GO:008022	9.3	TERF2, PPP2CB, ABL1, NEIL1, SIRT1, MAPK14
22	ubiquitin protein ligase binding	GO:031625	9.1	PML, POU5F1, TF, SUMO1, TP53, XRCC5
23	enzyme binding	GO:019899	8.9	POLB, PRKDC, H2AFX, TP53, ANK1, MSH3
24	chromatin binding	GO:003682	8.8	POLD1, TOP1, RPA1, TP53, CCNT1, ATRX
25	transcription factor binding	GO:008134	8.6	POU5F1, PRKDC, SUMO1, TP53, KAT2B, UBE2I
26	identical protein binding	GO:042802	7.7	ADIPOQ, SIRT1, TNF, TP53, APOE, GYPA
27	ATP binding	GO:005524	6.7	ATR, ATM, MLH1, INSR, MAPK14, MAPK1
28	DNA binding	GO:003677	6.4	FEN1, MAPK1, CCNT1, EXO1, TP53, ABL1
29	protein binding	GO:005515	0.2	WRNIP1, EFEMP1, ADIPOQ, WRN, NCL, YBX1