MCID: WRN001
MIFTS: 70

Werner Syndrome malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Skin diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Werner Syndrome

About this section
Sources:
49OMIM, 10Disease Ontology, 11diseasecard, 21GeneReviews, 45NIH Rare Diseases, 22GeneTests, 23Genetics Home Reference, 47Novoseek, 12DISEASES, 51Orphanet, 67UniProtKB/Swiss-Prot, 36MeSH, 65UMLS, 24GTR, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 34MedGen, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Werner Syndrome:

Name: Werner Syndrome 49 10 11 21 45 22 23 47 12 51 67 36 65
Werner's Syndrome 10 45 23
Adult Progeria 10 23 51
Ws 10 23 51
 
Werners Syndrome 23 24
Wrn 45 67
Adult Premature Ageing Syndrome 10
Adult Premature Aging Syndrome 23

Characteristics:

Orphanet epidemiological data:

51
werner syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Japan),1-9/100000; Age of onset: Adolescent,Adult

HPO:

61
werner syndrome:
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM49 277700
Disease Ontology10 DOID:5688
MeSH36 D014898
NCIt42 C3447
Orphanet51 902
ICD10 via Orphanet28 E34.8
MESH via Orphanet37 D014898
UMLS via Orphanet66 C0043119
MedGen34 C0043119
UMLS65 C0043119

Summaries for Werner Syndrome

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NIH Rare Diseases:45 Werner's syndrome is a disease chiefly characterized by premature aging and cancer predisposition. development is typically normal until the end of the first decade; the first sign is the lack of a growth spurt during puberty. early signs (usually in the 20s) include loss and graying of hair, hoarseness, and scleroderma-like skin changes, followed by cataracts, type 2 diabetes mellitus, hypogonadism, skin ulcers, and osteoporosis in the 30s. myocardial infarction (heart attack) and cancer are the most common causes of death, which typically occurs in the late 40s. it is caused by mutations in the wrn gene and is inherited in an autosomal recessive manner. management focuses on treatment of signs and symptoms and prevention of secondary complications. last updated: 4/29/2011

MalaCards based summary: Werner Syndrome, also known as werner's syndrome, is related to atypical werner syndrome and colorectal cancer, and has symptoms including lipoatrophy, abnormal hair quantity and abnormal hair whorl. An important gene associated with Werner Syndrome is WRN (Werner Syndrome RecQ Like Helicase), and among its related pathways are miRNA Regulation of DNA Damage Response and DNA damage_Role of Brca1 and Brca2 in DNA repair. Affiliated tissues include chromosome 8, skin and lung, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Disease Ontology:10 An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is caused by mutations in the WRN gene, located in chromosome 8.

UniProtKB/Swiss-Prot:67 Werner syndrome: A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction.

Genetics Home Reference:23 Werner syndrome is characterized by the dramatic, rapid appearance of features associated with normal aging. Individuals with this disorder typically grow and develop normally until they reach puberty. Affected teenagers usually do not have a growth spurt, resulting in short stature. The characteristic aged appearance of individuals with Werner syndrome typically begins to develop when they are in their twenties and includes graying and loss of hair; a hoarse voice; and thin, hardened skin. They may also have a facial appearance described as "bird-like." Many people with Werner syndrome have thin arms and legs and a thick trunk due to abnormal fat deposition.

Wikipedia:68 Werner syndrome (WS), also known as \"adult progeria\", is a rare, autosomal recessiveprogeroid syndrome... more...

Description from OMIM:49 277700

GeneReviews summary for NBK1514

Related Diseases for Werner Syndrome

About this section

Diseases related to Werner Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1atypical werner syndrome12.1
2colorectal cancer11.5
3waardenburg syndrome, type 2e, with or without neurologic involvement11.5
4aicardi-goutieres syndrome11.4
5spondylosis11.4
6williams-beuren syndrome11.3
7jejunal cancer11.3
8double uterus-hemivagina-renal agenesis10.9
9hutchinson-gilford progeria10.6
10progeria10.2
11waardenburg syndrome, type 110.2
12waardenburg syndrome, type 310.1
13waardenburg syndrome, type 2a10.1
14waardenburg syndrome, type 4a10.1
15qazi markouizos syndrome10.1LMNA, NBN, WRN
16waardenburg's syndrome10.0
17cd40 ligand deficiency10.0NBN, XRCC5
18baller-gerold syndrome10.0RECQL, RECQL4, WRN
19alpha-thalassemia myelodysplasia syndrome, somatic10.0HELLS, NBN, XRCC5
20bile reflux10.0
21waardenburg syndrome, type 2b10.0
22waardenburg syndrome, type 2c10.0
23waardenburg syndrome, type 2d10.0
24waardenburg syndrome, type 4b10.0
25waardenburg syndrome, type 4c10.0
26acrodermatitis enteropathica9.9RECQL, RECQL4, WRN
27ataxia-telangiectasia9.9
28bloom syndrome9.9
29ataxia9.9
303-methylglutaconic aciduria, type i9.9LMNA, RECQL4, RPA1
31peroxisome biogenesis disorder 5a9.9MRE11A, NBN, WRN
32breast cancer9.9
33coronary artery disease9.9
34osteoporosis9.9
35rothmund-thomson syndrome9.9
36cataract9.9
37artery disease9.9
38sarcoma9.9
39hyperglycemia9.9
40thyroiditis9.9
41cerebrooculofacioskeletal syndrome 39.8EXO1, FEN1
42lung cancer9.7
43hiv-19.7
44obesity9.7
45membranous nephropathy9.7
46chondrosarcoma9.7
47tangier disease9.7
48hypertriglyceridemia9.7
49pancreatic cancer9.7
50fragile x syndrome9.7

Graphical network of the top 20 diseases related to Werner Syndrome:



Diseases related to werner syndrome

Symptoms for Werner Syndrome

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Symptoms by clinical synopsis from OMIM:

277700

Clinical features from OMIM:

277700

Symptoms:

 51 (show all 56)
  • cataract/lens opacification
  • beaked nose
  • anomalies of chest/thorax/trunk
  • global upper and lower limbs anomalies
  • lipoatrophy
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • white forelock/piebaldism
  • abnormal fall of hair
  • pili torti
  • arterial atheroma/precocious atherosclerosis/arteriosclerosis
  • autosomal recessive inheritance
  • short stature/dwarfism/nanism
  • premature ageing
  • narrow face
  • retinitis pigmentosa/retinal pigmentary changes
  • small hand/acromicria
  • pes talus
  • skin hypoplasia/aplasia/atrophy
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • chronic skin infection/ulcerations/ulcers/cancrum
  • tight skin/lack of elasticity
  • telangiectasiae of the skin
  • abnormal cry/voice/phonation disorder/nasal speech
  • pulmonary artery stenosis/absence/hypoplasia of the pulmonary branches
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • arterial pulse abolition
  • testis anomalies
  • small/atrophic/hypoplastic testes/monorchism/microorchidism/anorchia
  • sterility/hypofertility
  • diabetes mellitus
  • late puberty/hypogonadism/hypogenitalism
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • osteosclerosis/osteopetrosis/bone condensation
  • periarticular tissue anomaly/extraarticular calcifications
  • abnormal fat distribution/lipodystrophy
  • laryngomalacia
  • chronic arterial hypertension
  • precocious menopause/secondary amenorrhea
  • cerebral vascular anomalies
  • restricted joint mobility/joint stiffness/ankylosis
  • neoplasms/tumors
  • oropharyngeal neoplasm/tumor/carcinoma/cancer
  • oral cavity/tongue neoplasm/tumor/carcinoma/cancer
  • digestive neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • thyroid neoplasm/tumor/carcinoma/cancer
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)
  • sarcoma
  • meningioma
  • autosomal dominant inheritance

HPO human phenotypes related to Werner Syndrome:

(show all 57)
id Description Frequency HPO Source Accession
1 lipoatrophy hallmark (90%) HP:0100578
2 abnormal hair quantity hallmark (90%) HP:0011362
3 abnormal hair whorl hallmark (90%) HP:0010721
4 prematurely aged appearance hallmark (90%) HP:0007495
5 short stature hallmark (90%) HP:0004322
6 pili torti hallmark (90%) HP:0003777
7 white forelock hallmark (90%) HP:0002211
8 abnormality of the thorax hallmark (90%) HP:0000765
9 cataract hallmark (90%) HP:0000518
10 convex nasal ridge hallmark (90%) HP:0000444
11 skin ulcer typical (50%) HP:0200042
12 lack of skin elasticity typical (50%) HP:0100679
13 telangiectasia of the skin typical (50%) HP:0100585
14 increased bone mineral density typical (50%) HP:0011001
15 aplasia/hypoplasia of the skin typical (50%) HP:0008065
16 abnormality of retinal pigmentation typical (50%) HP:0007703
17 abnormality of the pulmonary artery typical (50%) HP:0004414
18 reduced bone mineral density typical (50%) HP:0004349
19 short palm typical (50%) HP:0004279
20 skeletal muscle atrophy typical (50%) HP:0003202
21 rocker bottom foot typical (50%) HP:0001838
22 coronary artery disease typical (50%) HP:0001677
23 congestive heart failure typical (50%) HP:0001635
24 abnormality of the voice typical (50%) HP:0001608
25 hyperkeratosis typical (50%) HP:0000962
26 chondrocalcinosis typical (50%) HP:0000934
27 diabetes mellitus typical (50%) HP:0000819
28 narrow face typical (50%) HP:0000275
29 decreased fertility typical (50%) HP:0000144
30 abnormality of the testis typical (50%) HP:0000035
31 neoplasm of the small intestine occasional (7.5%) HP:0100833
32 abnormality of the cerebral vasculature occasional (7.5%) HP:0100659
33 neoplasm of the oral cavity occasional (7.5%) HP:0100649
34 ovarian neoplasm occasional (7.5%) HP:0100615
35 neoplasm of the lung occasional (7.5%) HP:0100526
36 neoplasm of the thyroid gland occasional (7.5%) HP:0100031
37 neoplasm of the breast occasional (7.5%) HP:0100013
38 renal neoplasm occasional (7.5%) HP:0009726
39 neoplasm of the skin occasional (7.5%) HP:0008069
40 meningioma occasional (7.5%) HP:0002858
41 laryngomalacia occasional (7.5%) HP:0001601
42 limitation of joint mobility occasional (7.5%) HP:0001376
43 secondary amenorrhea occasional (7.5%) HP:0000869
44 hypertension occasional (7.5%) HP:0000822
45 subcutaneous calcification HP:0007618
46 progeroid facial appearance HP:0005328
47 premature arteriosclerosis HP:0005177
48 short stature HP:0004322
49 meningioma HP:0002858
50 osteosarcoma HP:0002669
51 abnormality of the hair HP:0001595
52 osteoporosis HP:0000939
53 diabetes mellitus HP:0000819
54 retinal degeneration HP:0000546
55 cataract HP:0000518
56 convex nasal ridge HP:0000444
57 hypogonadism HP:0000135

UMLS symptoms related to Werner Syndrome:


muscle fibrosis, myokymia, psoas sign, rectal tenesmus, chills, spasm

Drugs & Therapeutics for Werner Syndrome

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Drugs for Werner Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 334)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bupivacaineapproved, investigationalPhase 4, Phase 39642180-92-92474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Hydrochloride
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
DepoBupivacaine
 
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
Exparel
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
Racemic bupivacaine
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Vivacaine
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
2
DopamineapprovedPhase 4, Phase 3, Phase 2308462-31-7, 51-61-6681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine Hcl
Dopamine Hydrochloride
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
 
KBio1_000780
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3
LevobupivacaineapprovedPhase 414627262-47-192253
Synonyms:
(-)-Bupivacaine
(-)-bupivacaine
(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(S)-1-Butyl-2',6'-pipecoloxylidide
(S)-Bupivacaine
(S)-bupivacaine
27262-47-1
27262-48-2
AC1L3NQM
BIDD:GT0471
C07887
C18H28N2O
CAS-18010-40-7
CHEBI:6149
CID92253
D08116
 
DB01002
L(-)-Bupivacaine
L-(-)-1-Butyl-2',6'-pipecoloxylidide
L-(-)-Bupivacaine
L-(-)-bupivacaine
LS-109843
LS-187025
LS-187789
Levobupivacaine
Levobupivacaine (INN)
Levobupivacaine [INN:BAN]
Levobupivacaine hydrochloride
MolPort-004-959-713
NCGC00016733-01
NCGC00159482-02
Novabupi
Novabupi (TN)
4
Testosteroneapproved, investigationalPhase 4, Phase 3, Phase 247458-22-06013
Synonyms:
(+)-testosterone
(+-)-8-iso-testosterone
(+-)-retrotestosterone
(+-)-testosterone
(17b)-17-hydroxy-androst-4-en-3-one
(17beta)-17-Hydroxyandrost-4-en-3-one
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
13-Iso-testosterone
17-Hydroxy-(17-beta)-androst-4-en-3-one
17-Hydroxy-(17beta)-androst-4-en-3-one
17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
17-Hydroxy-D4-androsten-3-one
17-Hydroxy-androst-4-en-3-one
17-beta-Hydroxy-delta(sup 4)-androsten-3-one
17-beta-Hydroxyandrost-4-en-3-one
17?-Hydroxy-4-androsten-3-one
17a-Hydroxy-(13a)-androst-4-en-3-one
17a-Hydroxy-13a-androst-4-en-3-one
17a-Hydroxy-14b-androst-4-en-3-one
17a-Hydroxy-androst-4-en-3-one
17b-Hydroxy-(10a)-androst-4-en-3-one
17b-Hydroxy-(13a)-androst-4-en-3-one
17b-Hydroxy-(8a)-androst-4-en-3-one
17b-Hydroxy-(8a,10a)-androst-4-en-3-one
17b-Hydroxy-(9b)-androst-4-en-3-one
17b-Hydroxy-(9b,10a)-androst-4-en-3-one
17b-Hydroxy-13a-androst-4-en-3-one
17b-Hydroxy-8a-androst-4-en-3-one
17b-Hydroxy-D4-androsten-3-one
17b-Hydroxy-androst-4-en-3-on
17b-Hydroxy-androst-4-en-3-one
17b-Hydroxyandrost-4-en-3-one
17b-Hydroxyandrost-4-ene-3-one
17b-Testosterone
17b-hydroxy-4-androsten-3-one
17beta-Hydroxy-3-oxo-4-androstene
17beta-Hydroxy-4-androsten-3-one
17beta-Hydroxy-delta(sup4)-androsten-3-one
17beta-Hydroxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-ene-3-one
17beta-hydroxy-4-androsten-3-one
4-Androsten-17?-ol-3-one
4-Androsten-17beta-ol-3-one
4-Androsten-3-one-17b-ol
4-androsten-17β-ol-3-one
4-androstene-17beta-ol-3-one
46923_FLUKA
46923_RIEDEL
58-22-0
7-beta-Hydroxyandrost-4-en-3-one
8-Iso-testosterone
9b,10a-Testosterone
9b-Testosterone
AA 2500
AC-14899
AC1L1LM0
Andriol
Andro
Andro 100
Andro L.A. 200
AndroGel
Androderm
Androderm (TN)
Androgel
Androgel (TN)
Android 10
Android 25
Android 5
Androlin
Andronaq
Andronate 100
Andronate 200
Andropatch
Andropository 200
Androsorb
Androst-4-en-17b-ol-3-one
Androst-4-en-17beta-ol-3-one
Androst-4-ene-17b-ol-3-one
Andrusol
Andryl 200
Aveed
Axiron
B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E
BIDD:ER0555
BIM-0061761.0001
Beta Testosterone
Bio-0678
Bio-T-Gel
C00535
CCRIS 574
CDB 111C
CHEBI:17347
CHEMBL386630
CID6013
CMC_13449
COL 1621
CP 601B
CPD000058344
Cristerona T
Cristerone T
D00075
D4-Androsten-17b-ol-3-one
DB00624
Dea No. 4000
Delatest
Delatestryl
Depo-Testadiol
Depo-Testosterone
Depo-Testosterone Cypionate
Depo-testosterone
Depotest
EINECS 200-370-5
Epitestosteron
Everone 200
Fortesta
Geno-Cristaux Gremy
Geno-cristaux Gremy
Geno-cristaux gremy
HMS2052N11
HSDB 3398
Halotensin
Homosteron
Homosterone
Intrinsa
 
LMST02020002
LS-148813
LibiGel
Libigel
Lumitestosteron
MLS000563091
MLS001032098
MLS001306401
MLS002174283
Malerone
Malestrone
Malestrone (amps)
Malogen in Oil
Malogen, Aquaspension Injection
Malogen, aquaspension injection
Mertestate
Metandren
Methyltestosterone
MolPort-002-506-901
NCGC00091018-01
NSC 9700
Natesto nasal gel
Neo-Hombreol F
Neo-Testis
Neo-testis
Neotestis
Oreton
Oreton F
Oreton Methyl
Oreton-F
Orquisteron
Perandren
Percutacrine Androgenique
Percutacrine androgenique
Primotest
Primoteston
Rac-17b-hydroxy-(13a)androst-4-en-3-one
Rac-17b-hydroxy-(8a)-androst-4-en-3-one
Rac-17b-hydroxy-(9b,10a)androst-4-en-3-one
Rac-17b-hydroxy-androst-4-en-3-one
Relibra
Retrotestosterone
S00309
S2033_Selleck
SAM001246921
SMR000058344
SMR001261453
Scheinpharm Testone-Cyp
Striant
Striant (TN)
Sustanon
Sustanone
Sustason 250
Synandrol F
T-Cypionate
T1500_SIGMA
T5411_FLUKA
T5411_SIGMA
TES
Teslen
Testamone 100
Testandrone
Testaqua
Testiculosterone
Testim
Testim (TN)
Testobase
Testoderm
Testoderm Tts
Testogel
Testoject-50
Testolent
Testolin
Testopel
Testopel Pellets
Testopropon
Testosteroid
Testosteron
Testosterona
Testosterona [INN-Spanish]
Testosterone
Testosterone (JAN/USP)
Testosterone Cypionate
Testosterone Enanthate
Testosterone Gel
Testosterone Heptanoate
Testosterone Hydrate
Testosterone Propionate
Testosterone Undecanoate
Testosterone [Androgenic steroids, anabolic]
Testosterone [INN:BAN]
Testosterone and its esters
Testosterone hydrate
Testosterone solution
Testosteronum
Testosteronum [INN-Latin]
Testostosterone
Testostérone
Testoviron
Testoviron Schering
Testoviron T
Testoxyl
Testred
Testred Cypionate 200
Testrin-P.A
Testro AQ
Testro Aq
Testrone
Testryl
Tostrelle
Tostrex
Trans-Testosterone
UNII-3XMK78S47O
Viatrel
Virilon
Virilon IM
Virormone
Virosterone
Vogelxo
ZINC06500184
beta testosterone
delta(sup 4)-Androsten-17(beta)-ol-3-one
delta4-Androsten-17beta-ol-3-one
delta4-androsten-17b-ol-3-one
testosterone
trans-Testosterone
5
MethyltestosteroneapprovedPhase 4, Phase 3, Phase 247458-18-46010
Synonyms:
17(alpha)-Methyl-delta(4)-androsten-17(beta)-ol-3-one
17-Methyltestosterone
17-beta-Hydroxy-17-methylandrost-4-en-3-one
17-methyltestosterone
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
17alpha-Methyl-delta(4)-androsten-17beta-ol-3-one
17alpha-Methyltestosterone
17alpha-methyl-delta-androsten-17beta-ol-3-one
17alpha-methyltestosterone
17beta-Hydroxy-17-methylandrost-4-en-3-one
 
17α-methyl-Δ4-androsten-17β-ol-3-one
17α-methyltestosterone
4-Androstene-17alpha-methyl-17beta-ol-3-one
Android
Methitest
Methyltestosterone
Methyltestosteronum
Metiltestosterona
NSC-9701
Testred
Testred C-III
Virilon
6
Esomeprazoleapproved, investigationalPhase 4308161796-78-74594, 9579578
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(-)-omeprazole
(S)-(-)-Omeprazole
(S)-(−)-omeprazole
(S)-Omeprazole
(S)-omeprazole
(s)-omeprazole
(−)-omeprazole
119141-88-7
119141-89-8
131959-78-9
172964-80-6
193469-77-1
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
326602-80-6
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1-methyl-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Axagon
BIDD:GT0020
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:50275
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CID9568614
CID9579578
CPD000058847
Ceprandal
D00455
D07917
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazol
Esomeprazole
Esomeprazole (INN)
Esomeprazole Sodium
Esomeprazole [INN:BAN]
Esomeprazolum
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20
Indurgan
Inexium paranova
Inexium paranova (TN)
Inhibitron
Inhipump
LS-185188
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
 
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
MolPort-005-943-880
Mopral
Morecon
NCGC00016925-01
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium Control
Nexium I.V.
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole (JAN/USP/INN)
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Perprazole
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UNII-N3PA6559FT
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
ZINC04693574
ZINC04693575
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
esomeprazole
esomeprazolum
omeprazole
Ésoméprazole
7
EverolimusapprovedPhase 4, Phase 2, Phase 11797159351-69-66442177
Synonyms:
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy
07741_FLUKA
159351-69-6
40-O-(2-hydroxyethyl)-rapamycin
42-O-(2-Hydroxyethyl)rapamycin
Afinitor
Afinitor Disperz
CERTICAN(R)
CHEMBL1201755
Certican
D02714
DB01590
 
Everolimus
Everolimus (JAN/USAN/INN)
Everolimus [USAN]
LS-143292
MolPort-003-847-342
MolPort-003-925-588
NCGC00167512-01
NVP-RAD-001
RAD 001
RAD-001
RAD-001C
RAD001
RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus
S1120_Selleck
SDZ-RAD
UNII-9HW64Q8G6G
VOTUBIA
Zortress
everolimus
8
Sirolimusapproved, investigationalPhase 4, Phase 2, Phase 1179753123-88-95284616, 6436030, 46835353
Synonyms:
(-)-Rapamycin
(-)-rapamycin
1fkb
1pbk
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29
3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
53123-88-9
A422989, NSC226080
AC-722
AC1L1JH9
AC1L7MJ9
AC1L9ZMV
AY 22989
AY-22989
AY22989
Ambotz53123-88-9
Antibiotic AY 22989
BIDD:PXR0165
Bio1_000293
Bio1_000782
Bio1_001271
Bio2_000375
Bio2_000855
BiomolKI2_000084
C07909
C51H79NO13
CBiol_002007
CCRIS 9024
CHEBI:100923
CHEBI:9168
CHEMBL413
CID10213190
CID10795871
CID11949238
CID11959112
CID313006
CID478951
CID5040
CID5284616
CID5358081
CID5374464
CID5460439
CID5497196
CID5924240
CID6436030
CID6610270
CID6610346
CID6711160
CID6713081
CID9833581
CID9854379
CID9854380
CID9962926
CID9962928
D00753
DB00877
DE-109
DivK1c_006936
 
FT-0082351
HMS2089A21
HSDB 7284
KBio1_001880
KBio2_000410
KBio2_002978
KBio2_005546
KBio3_000779
KBio3_000780
KBioGR_000410
KBioSS_000410
LCP-Siro
LMPK06000003
LS-143290
MLS000028373
MS-R001
MolMap_000043
MolPort-003-959-433
NCGC00021305-05
NCI60_001851
NCIMech_000355
NSC 226080
NSC226080
Perceiva
QTL1_000069
R0395_SIAL
R0395_SIGMA
RAP
RAPA
RPM
Rapammune
Rapamune
Rapamune (TN)
Rapamycin
Rapamycin (TN)
Rapamycin C-7, analog 4
Rapamycin Immunosuppressant Drug
Rapamycin from Streptomyces hygroscopicus
S1039_Selleck
SIIA 9268A
SILA 9268A
SILA9268A
SMP1_000255
SMR000058564
Sirolimus
Sirolimus (RAPAMUNE)
Sirolimus (USAN/INN)
Sirolimus [USAN:BAN:INN]
Sirolimus, Rapamune,Rapamycin
SpecPlus_000840
UNII-W36ZG6FT64
UNM-0000358684
WY-090217
Wy 090217
heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy
nchembio.100-comp4
nchembio.2007.42-comp2
nchembio.79-comp1
nchembio762-comp1
nchembio883-comp3
rapamycin
sirolimus
9
PantoprazoleapprovedPhase 4166102625-70-74679
Synonyms:
102625-70-7
5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole
5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
AC-679
AC1L1IPJ
Astropan
BIDD:GT0003
BRD-A22380646-001-01-5
BSPBio_002320
BY 1023
BY-1023
C11806
C16H15F2N3O4S
CHEBI:519598
CHEBI:7915
CHEMBL1502
CID4679
D05353
DB00213
HMS1922H20
HMS2090H03
HMS2093F14
HSDB 7292
I06-0068
LS-32883
MolPort-003-666-752
MolPort-005-933-577
NCGC00095188-01
NCGC00095188-02
NCGC00095188-03
 
Pantoloc
Pantopan
Pantoprazol
Pantoprazol [INN-Spanish]
Pantoprazole
Pantoprazole (USAN/INN)
Pantoprazole Magnesium
Pantoprazole Na
Pantoprazole Sodium
Pantoprazole Sodium Hydrate
Pantoprazole [USAN:BAN:INN]
Pantoprazole sodium
Pantoprazolum
Pantoprazolum [INN-Latin]
Pantoprozole
Pantor
Pantozol
Protium
Protonix
Protonix I.V.
Protonix IV
SBB070993
SK&F 96022
SK&F-96022
SK-96022
SKF-96022
SPECTRUM1505818
Somac
TL8000127
Tecta
UNII-D8TST4O562
pantoprazole
10
VerapamilapprovedPhase 411752-53-92520
Synonyms:
(+-)-Verapamil
(+/-)-VERAPAMIL
(1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
52-53-9
56949-77-0
AB00053495
AC-16016
AC1L1DV5
Akilen
Anpec
Apo-Verap
Arpamyl
Arpamyl LP
BPBio1_000268
BRD-A09533288-001-02-7
BRD-A09533288-003-05-6
BSPBio_000242
BSPBio_001513
BSPBio_002358
Berkatens
Bio-0754
Bio1_000425
Bio1_000914
Bio1_001403
Bio2_000233
Bio2_000713
C07188
C27H38N2O4
CCRIS 6749
CHEBI:9948
CHEMBL6966
CID2520
CP-16533-1
CP-165331
Calan
Calan SR
Calan Sr
Calan sr
Calaptin
Calaptin 240 SR
Calcan
Cardiabeltin
Cardiagutt
Cardibeltin
Cardioprotect
Caveril
Civicor
Civicor Retard
Coraver
Cordilox
Cordilox SR
Corpamil
Covera-HS
Covera-Hs
Covera-hs
D-365
D02356
DB00661
Dexverapamil
Dignover
Dilacoran
Dilacoran HTA
DivK1c_000399
Drosteakard
Durasoptin
EINECS 200-145-1
EINECS 260-462-6
Elthon
FT-0080127
Falicard
Finoptin
Flamon
Geangin
HMS1791L15
HMS1989L15
HMS2089H17
Harteze
Hexasoptin
Hexasoptin Retard
Hormitol
I06-0063
IDI1_000399
IDI1_033983
Ikacor
Ikapress
Inselon
Iproveratril
Isoptimo
Isoptin
Isoptin Retard
Isoptin SR
Isoptin sr
Isoptine
Isoptino
Isotopin
Izoptin
Jenapamil
KBio1_000399
KBio2_000233
KBio2_002343
KBio2_002801
KBio2_004911
KBio2_005369
KBio2_007479
KBio3_000465
KBio3_000466
KBio3_002823
KBioGR_000233
 
KBioGR_001372
KBioGR_002343
KBioSS_000233
KBioSS_002346
L001330
LS-174
Lekoptin
Lodixal
Lopac0_001237
Magotiron
Manidon
Manidon Retard
MolPort-000-721-258
NCGC00016083-14
NCGC00024710-04
NCGC00024710-05
NCGC00024710-06
NCGC00024710-07
NCGC00024710-08
NCGC00024710-09
NCI60_020143
NINDS_000399
NSC272366
NU-Verap
Novapamyl LP
Novo-Veramil
Nu-Verap
Ormil
Praecicor
Prestwick0_000141
Prestwick1_000141
Prestwick2_000141
Prestwick3_000141
Quasar
Rapam
Robatelan
SID104171262
SID124881789
SID124881790
SPBio_001820
SPBio_002181
STK538085
Securon
Spectrum2_001740
Spectrum4_000906
Spectrum5_001786
Tarka
UNII-CJ0O37KU29
Univer
Univex
VERAPAMIL
Vasolan
Vasomil
Vasopten
Vera-Sanorania
Verabeta
Veracaps SR
Veracim
Veracor
Verahexal
Veraloc
Veramex
Veramil
Verapamil
Verapamil (USAN/INN)
Verapamil AL
Verapamil Acis
Verapamil Atid
Verapamil Basics
Verapamil Ebewe
Verapamil HCl
Verapamil Henning
Verapamil Hydrochloride
Verapamil Injection
Verapamil MSD
Verapamil NM
Verapamil NM Pharma
Verapamil Nordic
Verapamil PB
Verapamil Riker
Verapamil SR
Verapamil Verla
Verapamil [USAN:BAN:INN]
Verapamil [USAN:INN:BAN]
Verapamil [Usan:Ban:Inn]
Verapamil-AbZ
Verapamilo
Verapamilo [INN-Spanish]
Verapamilum
Verapamilum [INN-Latin]
Verapin
Verapress 240 SR
Veraptin
Verasal
Verasifar
Veratensin
Verdilac
Verelan
Verelan PM
Verelan Pm
Verelan SR
Verexamil
Veroptinstada
Verpamil
Vetrimil
Vortac
Vérapamil
alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
cMAP_000023
delta-365
nchembio.368-comp2
nchembio.79-comp5
11
PhenprocoumonapprovedPhase 427435-97-29908, 54680692
Synonyms:
2-hydroxy-3-(1-phenylpropyl)chromen-4-one
3-(1'-Phenyl-propyl)-4-oxycoumarin
3-(1'-Phenyl-propyl)-4-oxycoumarin [German]
3-(1-Phenylpropyl)-4-hydroxycoumarin
3-(alpha-Ethylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenylpropyl)-4-hydroxycoumarin
4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
435-97-2
AC1L1U3E
AKOS002126557
BRN 1291115
CHEBI:117471
CHEBI:50438
CHEMBL1465
CHEMBL16694
CID9908
D010644
D05457
DB00946
EINECS 207-108-9
Falithiom
Falithrom
Fencumar
Fenprocoumona
Fenprocoumona [INN-Spanish]
Fenprocumon
Fenprocumone
Fenprocumone [DCIT]
 
HSDB 3248
Hexal Brand of Phenprocoumon
LS-55203
Liquamar
Liquamar (TN)
Marcoumar
Marcumar
Marcuphen
MolPort-005-935-554
Oprea1_002598
PHENPROCOUMON
Phenprocoumalol
Phenprocoumarol
Phenprocoumarole
Phenprocoumon (USAN/INN)
Phenprocoumon [USAN:INN:BAN]
Phenprocoumone
Phenprocoumone [INN-French]
Phenprocoumonum
Phenprocoumonum [INN-Latin]
Phenprocumone
Phenprocumonum
Phenprogramma
Phenylpropylhydroxycumarinum
Ro 1-4849
Roche Brand of Phenprocoumon
S2188_Selleck
U29342
UNII-Q08SIO485D
Worwag Brand of Phenprocoumon
fenprocumon
12
TiclopidineapprovedPhase 419355142-85-35472
Synonyms:
5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine
55142-85-3
AC-15204
AC1L1KFB
BIDD:PXR0169
BPBio1_000191
BRD-K00603606-003-03-4
BRN 1216802
BSPBio_000173
C07140
C14H14ClNS
CAS-53885-35-1
CHEBI:9588
CHEMBL833
CID5472
D08594
DB00208
EINECS 259-498-5
HMS2089I18
L001108
LS-152434
MLS001201825
MolPort-002-507-849
 
NCGC00016872-01
NCGC00016872-02
NCGC00024361-04
PCR 5332
Prestwick0_000047
Prestwick1_000047
Prestwick2_000047
Prestwick3_000047
SMR000641861
SPBio_002094
STK589340
STOCK5S-54105
Ticlid
Ticlopidin-Puren
Ticlopidin-Puren (TN)
Ticlopidina
Ticlopidina [INN-Spanish]
Ticlopidine (INN)
Ticlopidine HCL
Ticlopidine Hydrochloride
Ticlopidine [INN:BAN]
Ticlopidinum
Ticlopidinum [INN-Latin]
UNII-OM90ZUW7M1
UNM-0000345023
ZINC19594599
ticlopidine
13
RivaroxabanapprovedPhase 4215366789-02-8
Synonyms:
BAY 59-7939
 
BAY59-7939
Xarelto
14
FurosemideapprovedPhase 417154-31-93440
Synonyms:
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
41733-55-5 (mono-hydrochloride salt)
5-18-09-00555 (Beilstein Handbook Reference)
54-31-9
AB00052001
AC-11067
AC1L1FXW
AC1Q557O
AKOS000266625
ARONIS24304
Acetic acid potassium salt
Aisemide
Aldalix
Aldic
Aluzine
Anfuramaide
Apo-Frusemide
Apo-Furosemide
Aquarid
Aquasin
Arasemide
BIDD:GT0139
BPBio1_000443
BRD-K78010432-001-05-8
BRN 0840915
BSPBio_000401
BSPBio_002054
Beronald
Bio-0044
Bioretic
Bristab
Bristurin
C12H11ClN2O5S
CAS-54-31-9
CCRIS 1951
CHEBI:47426
CHEMBL35
CID3440
CPD000058202
Cetasix
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]
D00331
D005665
DB00695
DB07799
Depix
Desal
Desdemin
Di-Ademil
Dihydroflumethiazide
Dirine
Disal
Discoid
Disemide
Diucardin
Diumide-K
Diural
Diurapid
Diuretic Salt
Diuretic salt
Diurin
Diurolasa
Diusemide
Diusil
Diuzol
DivK1c_000575
Dranex
Dryptal
Durafurid
EINECS 200-203-6
Edemid
Edenol
Eliur
Elodrine
Endural
Errolon
Eutensin
F0182
F4381_SIGMA
FUN
FUROSEMIDE USP
Farsix
Finuret
Fluidrol
Fluss
Franyl
Frumex
Frumide
Frumil
Frusedan
Frusema
Frusemid
Frusemide
Frusemin
Frusenex
Frusetic
Frusid
Fu sid
Fulsix
Fuluvamide
Fuluvamine
Furanthril
Furanthryl
Furantral
Furantril
Furanturil
Furesis
Furetic
Furex
Furfan
Furix
Furmid
Furo-Basan
Furo-Puren
Furo-puren
Furobeta
Furocot
Furodiurol
Furodrix
Furomen
Furomex
Furomide M.D
Furomide M.D.
Furorese
Furosan
Furose
Furosedon
Furosemid
Furosemida
Furosemida [INN-Spanish]
Furosemide
Furosemide "mita"
Furosemide (JP15/USP/INN)
Furosemide Monohydrochloride
Furosemide Monosodium Salt
Furosemide [USAN:INN:JAN]
Furosemidu
Furosemidu [Polish]
Furosemidum
Furosemidum [INN-Latin]
Furosemix
Furoside
Furosifar
Furosix
Furoter
Furovite
Fursemid
Fursemida
Fursemide
Fursol
Fusid
Fusidic acid
 
Golan
HMS1569E03
HMS1920B03
HMS2090K06
HMS2091H05
HMS501M17
HSDB 3086
Hissuflux
Hoe-058A
Hydol
Hydrenox
Hydrex
Hydro
Hydro-Rapid
Hydro-rapid
Hydroled
I04-0179
IDI1_000575
Impugan
Jenafusid
KBio1_000575
KBio2_001580
KBio2_004148
KBio2_006716
KBio3_001274
KBioGR_001259
KBioSS_001580
Katlex
Kofuzon
Kolkin
Kutrix
LB 502
LB-502
LS-204
Lasemid
Lasex
Lasiletten
Lasilix
Lasix
Lasix (TN)
Lasix (tn)
Lasix Retard
Lasix Special
Lasix, Frusemide, Furosemide
Laxur
Lazix
Leodrine
Less Diur
Liside
Logirene
Lowpston
Lowpstron
Luscek
MLS001066374
MLS001306403
Macasirool
Marsemide
Metflorylthiazidine
Methforylthiazidine
Mirfat
Mita
Moilarorin
MolPort-001-641-065
Myrosemide
NCGC00016241-01
NCGC00090893-01
NCGC00090893-02
NCGC00090893-03
NCGC00090893-05
NCGC00090893-06
NCI-C55936
NINDS_000575
NSC 269420
NSC269420
Nadis
Nelsix
Neo-Renal
Neo-renal
Nephron
Nicorol
Novosemide
Octan Draselny
Octan draselny
Odemase
Odemex
Oedemex
Olmagran
Oprea1_667724
Osyrol
Polysquall A
Prefemin
Prestwick0_000341
Prestwick1_000341
Prestwick2_000341
Prestwick3_000341
Prestwick_752
Profemin
Promedes
Promide
Protargen
Puresis
Radisemide
Radonna
Radouna
Retep
Rodiuran
Rontyl
Rosemide
Rosis
Rusyde
S1603_Selleck
SAM002264614
SMP1_000129
SMR000058202
SPBio_001129
SPBio_002322
SPECTRUM1500310
STK177334
Sal Diureticum
Sal diureticum
Salinex
Salix
Salix (brand of furosemide)
Salurex
Salurid
Saluron
Seguril
Selectofur
Sigasalur
Sisuril
Spectrum2_001005
Spectrum3_000437
Spectrum4_000560
Spectrum5_000744
Spectrum_001100
Spirofur
Synephron
TL8003563
Transit
Trofurit
UNII-7LXU5N7ZO5
UPCMLD-DP022
UPCMLD-DP022:001
Uremide
Uresix
Urex
Urex-M
Urian
Uridon
Uritol
Urosemide
Vergonil
Vesix
WLN: T5OJ B1MR CG FVQ DSZW
Yidoli
Zafimida
fulvamide
furosemide
furosemide ''mita''
less Diur
15
Menadioneapproved, nutraceuticalPhase 419958-27-54055
Synonyms:
03AAE1E9-B215-45AF-976C-91E61894A467
1,4-Naphthalenedione, 2-methyl-, radical ion(1-)
2-Methyl-1,4-Naphthalenedione
2-Methyl-1,4-naftochinon
2-Methyl-1,4-naftochinon [Czech]
2-Methyl-1,4-naphthalendione
2-Methyl-1,4-naphthalenedione
2-Methyl-1,4-naphthochinon
2-Methyl-1,4-naphthochinon [German]
2-Methyl-1,4-naphthodione
2-Methyl-1,4-naphthoquinone
2-Methylnaphthoquinone
2-methyl-1,4-naphthoquinone, 5
2-methylnaphthalene-1,4-dione
3-Methyl-1,4-naphthoquinone
34524-96-4
47775_SUPELCO
58-27-5
72060-21-0
AC1L1HBA
AC1Q2HB3
AI3-14700
AKOS004910447
ARONIS24154
Aquakay
Aquinone
BB_NC-2319
BIDD:ER0556
BPBio1_000592
BSPBio_000538
Bio1_000471
Bio1_000960
Bio1_001449
C05377
C11H8O2
CAS-58-27-5
CCRIS 6672
CHEBI:28869
CHEMBL590
CID4055
CPD-3766
D02335
DB00170
DivK1c_000080
DivK1c_006287
EINECS 200-372-6
HMS1569K20
HMS1921P06
HMS2092F12
HMS500D22
HSDB 3354
Hemodal
I14-2821
IDI1_000080
InChI=1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H
Juva-K
K-Thrombyl
K-Vitan
KBio1_000080
KBio1_001231
KBio2_001708
KBio2_002527
KBio2_004276
KBio2_005095
KBio2_006844
KBio2_007663
KBio3_003005
KBioGR_000984
KBioGR_002527
KBioSS_001708
KBioSS_002535
Kaergona
Kanone
Kappaxan
Kappaxan (VAN)
Kappaxin
Kappaxin (TN)
Karcon
Kareon
Kativ-G
Kayklot
Kaykot
 
Kaynone
Kayquinone
Kipca
Kipca, oil soluble
Kipca-Oil Soluble
Klottone
Koaxin
Kolklot
LS-95653
LS-95654
M0373
M5625_SIGMA
M9429_SIGMA
MLS000069420
MLS001148443
MNQ
Memodol
Menadiol diphosphate
Menadion
Menadione
Menadione (K3)
Menadione (USP)
Menadione [USAN:BAN]
Menadione semiquinone
Menadionum
Menaphthene
Menaphthon
Menaphthone
Menaphtone
Menaquinone
Menaquinone 0
Menaquinone O
Methyl-1,4-naphthalenedione
Methyl-1,4-naphthoquinone
Methylnaphthoquinone
Mitenon
Mitenone
MolPort-001-766-699
NCGC00016258-01
NCGC00094978-01
NCGC00094978-02
NCI60_003945
NCIMech_000105
NINDS_000080
NSC 4170
NSC4170
Panosine
Prestwick0_000459
Prestwick1_000459
Prestwick2_000459
Prestwick3_000459
Prestwick_313
Prokayvit
QTL1_000056
S1949_Selleck
SMR000059102
SMR000653532
SPBio_001267
SPBio_002477
SPECTRUM1502254
SpecPlus_000191
Spectrum2_001194
Spectrum4_000722
Spectrum5_001764
Spectrum_001228
Synkay
Thyloquinone
UNII-723JX6CXY5
Usaf ek-5185
VK3
Vicasol
Vitamin K 3
Vitamin K0
Vitamin K2
Vitamin K2(0)
Vitamin K3
Vitamin K3 : 2-Methyl-1,4-naphthoquinone
Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
Vitamin-?K3
WLN: L66 BV EVJ C1
ZINC00001677
cMAP_000077
menadione
nchembio.109-comp5
16
Phytonadioneapproved, NutraceuticalPhase 419984-80-04812, 5284607
Synonyms:
.alpha.-Phylloquinone
1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-)
10485-69-5
11104-38-4
15973-57-6
2', 3'-trans-Vitamin K1
2',3'-trans-Vitamin K1
2-(3,7,11,15-Tetramethylhexadec-2-enyl)-3-methylnaphthalene-1,4-dione
2-METHYL-3-PHYTYL-14-NAPHTHOQUINONE
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone
2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
2-Methyl-3-phythyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon [German]
2-Methyl-3-phytyl-1,4-naphthoquinone
2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione
2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
27696-10-2
3-Phytylmenadione
50926-17-5
84-80-0
AC1NQX34
AC1Q6B3J
AR-1E3503
Antihemorrhagic vitamin
Aqua mephyton
Aqua-Mephytin
Aquamephyton
C02059
C31H46O2
CID5280483
Combinal K1
D00148
DB01022
EINECS 201-564-2
EINECS 234-330-3
EINECS 279-833-9
Fitomenadiona
Fitomenadiona [INN-Spanish]
Fitomenadione
Fitomenadione [DCIT]
HSDB 3162
K-Ject
Kativ N
Kephton
 
Kinadion
Konakion
LS-94617
LT00452032
MLS001332659
MLS001332660
Mephyton
Mephyton (TN)
MolPort-001-785-978
Mono-Kay
Monodion
NCGC00159423-02
NSC 270681
NSC270681
P0642
Phyllochinon
Phyllochinon [German]
Phyllochinonum
Phylloquinone
Phylloquinone (8CI)
Phythyl-menadion
Phythyl-menadion (GERMAN)
Phytomenadione
Phytomenadione (INN)
Phytomenadionum
Phytomenadionum [INN-Latin]
Phytonadione
Phytonadione (JP15/USP)
Phytonadione [USAN:JAN]
Phytonadionum
Phytylmenadione
SMR000059144
ST075162
Synthex P
UNII-A034SE7857
VITAMIN K
VITAMIN K1
Vitamin K
Vitamin K 1
Vitamin K1
Vitamin K1 (TN)
Vitamin K1 (VAN)
Vitamin K1 (generic)
Vitamin K1(20)
alpha-Phylloquinone
phyllohydroquinone
phytonadione
trans-Phylloquinone
α-phylloquinone
17
Clopidogrelapproved, nutraceuticalPhase 4717120202-66-6, 113665-84-260606
Synonyms:
( )-(S)-Clopidogrel
(+)-(S)-Clopidogrel
(+)-Clopidogrel
(S)-Clopidogrel
(S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
113665-84-2
AC-19024
AC1L1TKZ
AC1Q41I9
BIDD:GT0284
BRD-K27721098-065-02-9
BSPBio_003211
C16H16ClNO2S
CGE
CHEBI:37941
CHEMBL1771
CID60606
CLOPIDOGREL SULFATE
CPD000550475
Clopidogrel
Clopidogrel (INN)
Clopidogrel (TN)
Clopidogrel Bisulfate
Clopidogrel [BAN:INN]
Clopidogrel [Ban:Inn]
Clopidogrel [INN:BAN]
Clopidogrel bisulfate
Clopidogrel bisulphate
Clopidogrel sulfate
Clopidogrelum
D07729
DB00758
DivK1c_000787
HMS2090O21
HMS502H09
HSDB 7430
 
IDI1_000787
Isocover
KBio1_000787
KBio2_000545
KBio2_003113
KBio2_005681
KBio3_002431
KBioGR_000689
KBioSS_000545
LS-172232
MLS001165708
MLS001195633
MLS001304711
Methyl (+)-(S)-alpha-(o-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4H)-acetate
MolPort-002-885-817
MolPort-003-845-991
NCGC00163329-02
NINDS_000787
Plavix
Plavix (TN)
SAM002589956
SMR000550475
SPBio_000463
SR 25990
STK580572
STOCK5S-27782
Spectrum2_000512
Spectrum3_001606
Spectrum4_000175
Spectrum_000105
TL8000400
UNII-A74586SNO7
Zyllt
clopidogrel
clopidogrel, (+)(S)-isomer
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate
methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
nchem.651-comp8
18Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 29988
19Hormone AntagonistsPhase 4, Phase 3, Phase 210002
20Antineoplastic Agents, HormonalPhase 4, Phase 3, Phase 24256
21Anabolic AgentsPhase 4, Phase 3, Phase 2375
22Bone Density Conservation AgentsPhase 4, Phase 3, Phase 22600
23
Testosterone enanthatePhase 4, Phase 3, Phase 2474315-37-79416
Synonyms:
17-((1-Oxoheptyl)oxy)androst-4-en-3-one
17-Hydroxyandrost-4-en-3-one, 17-heptanoate
17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid
17beta-Enanthoxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-en-3-one enanthate
4-Androsten-17beta-ol-3-one 17-enanthate
4-Androsten-3-one 17beta-enanthate
Androgyn L.A.
Andropository
Androtardyl
Atlatest
DEA No. 4000
DePatestrye
Delatest
Delatestryl
Depo-Testro Med
Ditate
Durathate
Everone
 
Exten test
Malogen L.A.
Malogen L.A.200
Orquisteron-E
Primotestone
Reposo TMD
Testanthate
Testate
Testenate
Testinon
Testoenant
Testonenant
Testosterone 17-enanthate
Testosterone 17beta-heptanoate
Testosterone 17beta-heptanoic acid
Testosterone enantate
Testosterone heptoate
Testosterone heptoic acid
Testosterone heptylate
Testosterone oenanthate
Testostroval
24Platelet Aggregation InhibitorsPhase 4, Phase 31935
25Fibrinolytic AgentsPhase 4, Phase 21567
26Testosterone undecanoatePhase 4, Phase 3, Phase 2474
27Cytochrome P-450 Enzyme InhibitorsPhase 4, Phase 2, Phase 13036
28Testosterone 17 beta-cypionatePhase 4, Phase 3, Phase 2474
29AndrogensPhase 4, Phase 3, Phase 21162
30Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 114795
31Dopamine AgentsPhase 4, Phase 3, Phase 23084
32Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 2, Phase 118510
33Protective AgentsPhase 4, Phase 3, Phase 25651
34AnestheticsPhase 4, Phase 3, Phase 17385
35
Proton pump inhibitorsPhase 4958
Synonyms:
 
PPIs
36Gastrointestinal AgentsPhase 4, Phase 36401
37HormonesPhase 4, Phase 3, Phase 211748
38
Zoledronic acidPhase 4286118072-93-868740
Synonyms:
(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
(1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate
118072-93-8
2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
AC-1092
AC1L2ACJ
AC1Q6RN3
AKOS005145739
Aclasta
BIDD:GT0292
BIDD:PXR0134
Bio-0112
Bisphosphonate 3
C088658
CGP 42'446
CGP 42446
CGP 42446A
CGP-42'446
CGP-42446
CHEBI:46557
CHEMBL924
CID68740
D08689
 
DB00399
FT-0082657
HMS2089O09
I06-0710
KS-1132
LS-181815
MolPort-002-885-874
MolPort-003-850-890
NCGC00159521-02
NCGC00159521-03
NSC721517
Novartis brand of zoledronic acid
Reclast
Reclast (TN)
S00092
S1314_Selleck
UNII-70HZ18PH24
ZOL
Zoledronate
Zoledronic acid
Zoledronic acid (INN)
Zoledronic acid [USAN:INN]
Zometa
Zometa (Novartis)
Zometa (TN)
Zometa Concentrate
Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid
[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
39AntacidsPhase 41453
40Anti-Ulcer AgentsPhase 41453
41Central Nervous System DepressantsPhase 4, Phase 3, Phase 2, Phase 110016
42Anesthetics, LocalPhase 4, Phase 32347
43ImmunoglobulinsPhase 4, Phase 3, Phase 24477
44AntibodiesPhase 4, Phase 3, Phase 24477
45Protease InhibitorsPhase 4, Phase 2, Phase 34558
46HIV Protease InhibitorsPhase 4, Phase 2, Phase 34558
47MicronutrientsPhase 4, Phase 33901
48Antithrombin IIIPhase 4563
49Trace ElementsPhase 4, Phase 33900
50AntithrombinsPhase 4574

Interventional clinical trials:

(show top 50)    (show all 251)
idNameStatusNCT IDPhase
1Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial FibrillationCompletedNCT00161538Phase 4
2Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Density in Hormone Sensitive Prostate Cancer Patients With Bone MetastasisCompletedNCT00035997Phase 4
3Radiofrequency Ablation for Malignant Biliary ObstructionCompletedNCT01758341Phase 4
4Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342)CompletedNCT00325676Phase 4
5Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected PatientsCompletedNCT00574925Phase 4
6Donor Dopamine and Initial Graft FunctionCompletedNCT00115115Phase 4
7Pain Reduction After CholecystectomyCompletedNCT01199406Phase 4
8Biomarker Guided Treatment in Gynaecological CancerRecruitingNCT02543710Phase 4
9European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic StrokeRecruitingNCT02678169Phase 4
10Multicenter Study of Immunoadsorption in Dilated CardiomyopathyRecruitingNCT00558584Phase 4
11Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After Pulmonary Vein Isolation for Atrial FibrillationRecruitingNCT02067182Phase 4
12Balloon Angioplasty Versus Xpert Stent in CLI Patients XXS StudyRecruitingNCT00546845Phase 4
13Pinloc Versus Hansson Pins in the Treatment of Femoral Neck Fractures.RecruitingNCT02776631Phase 4
14Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal MenActive, not recruitingNCT01699178Phase 4
15Long-term Safety, Curvature Deformity Characterization, and Immunogenicity Over Time in Subjects Previously Treated With AA4500 for Peyronies DiseaseActive, not recruitingNCT02298829Phase 4
16Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male VolunteersNot yet recruitingNCT01156220Phase 4
17COMBO-Stent in Patients on Chronic Anticoagulant Therapy (COSTA) COSTA-Bleed and COSTA-Outcome TrialsNot yet recruitingNCT02723981Phase 4
18Bladder Scan of Residual Urine With New CatheterCompletedNCT01048541Phase 2, Phase 3
19Monoclonal Antibody Therapy (Rencarex®) in Treating Patients Who Have Undergone Surgery for Non-metastatic Kidney CancerCompletedNCT00087022Phase 3
20Efficacy, Safety, Tolerability of Neramexane in Patients With Subjective TinnitusCompletedNCT00955799Phase 3
21Efficacy, Safety and Tolerability of Neramexane in Patients With Subjective TinnitusCompletedNCT00739635Phase 3
22Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal MenCompletedNCT01403116Phase 3
23Study of AA4500 in the Treatment of Peyronie's DiseaseCompletedNCT01221623Phase 3
24Study of Atrasentan in Men With Non-Metastatic, Hormone-Refractory Prostate CancerCompletedNCT00036556Phase 3
25Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)CompletedNCT00106691Phase 3
26Study to Investigate Efficacy and Safety of a New Oral ContraceptiveCompletedNCT00185289Phase 3
27Efficacy and Long-Term Safety of Vildagliptin as Add-on Therapy to Metformin in Patients With Type 2 DiabetesCompletedNCT00860288Phase 2, Phase 3
28Study About Efficacy and Safety to Treat Multi-System-AtrophyCompletedNCT00146809Phase 3
29Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment (BY2001/M1-007)CompletedNCT00074906Phase 3
30Efficacy and Safety Trial of Transcranial Laser Therapy Within 24 Hours From Stroke Onset (NEST-3)CompletedNCT01120301Phase 3
31Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.CompletedNCT01218607Phase 3
32Gemcitabine With or Without Capecitabine in Treating Patients With Advanced Pancreatic CancerCompletedNCT00030732Phase 3
33Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope SurgeryCompletedNCT01219881Phase 3
34Comparing Two Forms of Head Immobilization for Stereotactic RadiotherapyCompletedNCT00328510Phase 3
35Trigger-point Blockade in Persistent Pain After Open Groin Hernia RepairCompletedNCT02065219Phase 3
36Tasigna and Interferon Alpha Evaluation Initiated by the German Chronic Myeloid Leukemia Study Group - the TIGER StudyRecruitingNCT01657604Phase 3
37Telemedical Interventional Management in Heart Failure IIRecruitingNCT01878630Phase 3
38Comparison of Oral Octreotide Capsules to Injectable Somatostatin Analogs in AcromegalyRecruitingNCT02685709Phase 3
39Bryophyllum Pinnatum Versus Solifenacin Versus Placebo for Overactive BladderRecruitingNCT02129816Phase 2, Phase 3
40PUVA Maintenance Therapy in Mycosis FungoidesRecruitingNCT01686594Phase 3
41Multi Centre Trial of DSMM for Newly Diagnosed Multiple Myeloma up to 60 YearsRecruitingNCT00546988Phase 3
42Evaluation of MGN1703 Maintenance Treatment in Patients With mCRC With Tumor Reduction During Induction TreatmentRecruitingNCT02077868Phase 3
43Diet and Physical Activity Change or Usual Care in Improving Progression-Free Survival in Patients With Previously Treated Stage II, III, or IV Ovarian, Fallopian Tube, or Primary Peritoneal CancerRecruitingNCT00719303Phase 3
44ELUVIA™ Drug-eluting Stent Versus Zilver® PTX® StentRecruitingNCT02574481Phase 3
45Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung CancerRecruitingNCT01993810Phase 3
46Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate CancerRecruitingNCT01368588Phase 3
47Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and EtoposideRecruitingNCT00632853Phase 3
48Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or MetastaticRecruitingNCT02115282Phase 3
49Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube CancerRecruitingNCT00565851Phase 3
50A Study of Galeterone Compared to Enzalutamide In Men Expressing Androgen Receptor Splice Variant-7 mRNA (AR-V7) Metastatic CRPCRecruitingNCT02438007Phase 3

Search NIH Clinical Center for Werner Syndrome


Cochrane evidence based reviews: werner syndrome

Genetic Tests for Werner Syndrome

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Genetic tests related to Werner Syndrome:

id Genetic test Affiliating Genes
1 Werner Syndrome22 WRN

Anatomical Context for Werner Syndrome

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MalaCards organs/tissues related to Werner Syndrome:

33
Skin, Lung, Heart, Prostate, Bone, Brain, Thyroid

FMA organs/tissues related to Werner Syndrome:

16
Chromosome 8

Animal Models for Werner Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Werner Syndrome:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0FEN1, HELLS, LMNA, RECQL4, WRN
2MP:00053718.8HELLS, LMNA, RECQL4, VCP, WRN
3MP:00053818.7FEN1, LMNA, POLB, RECQL4, WRN, XRCC5
4MP:00053897.8EXO1, LMNA, MRE11A, NBN, PARP1, WRN
5MP:00107717.8BLM, HELLS, LMNA, PARP1, POLB, RECQL4
6MP:00053807.8BLM, FEN1, HELLS, MRE11A, NBN, PARP1
7MP:00053797.3EXO1, FEN1, HELLS, LMNA, NBN, POLB
8MP:00020067.1BLM, EXO1, FEN1, MRE11A, NBN, RECQL4
9MP:00053786.5BLM, FEN1, HELLS, LMNA, NBN, PARP1
10MP:00053766.4EXO1, FEN1, HELLS, LMNA, MRE11A, NBN
11MP:00107684.9BLM, EXO1, FEN1, HELLS, LMNA, MRE11A
12MP:00053844.8BLM, EXO1, FEN1, HELLS, LMNA, MRE11A
13MP:00053874.8BLM, EXO1, FEN1, HELLS, LMNA, MRE11A
14MP:00053974.7BLM, EXO1, FEN1, HELLS, LMNA, MRE11A

Publications for Werner Syndrome

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Articles related to Werner Syndrome:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome. (26172944)
2015
2
Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span. (25346348)
2014
3
First Japanese case of atypical progeroid syndrome/atypical Werner syndrome with heterozygous LMNA mutation. (25327215)
2014
4
DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations. (23847654)
2013
5
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. (23867477)
2013
6
Diabetes mellitus and cancer in Werner syndrome. (23386316)
2013
7
Leg ulcer in Werner syndrome (adult progeria): a case report. (23552003)
2013
8
The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome. (23360642)
2013
9
The Werner syndrome protein: linking the replication checkpoint response to genome stability. (21389352)
2011
10
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. (20516064)
2010
11
Estrogen prevents senescence through induction of WRN, Werner syndrome protein. (20395656)
2010
12
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. (20237955)
2010
13
Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. (20536832)
2010
14
Werner syndrome as a possible cause of non-alcoholic steatohepatitis. (19720629)
2009
15
Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein. (18588880)
2008
16
Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome. (20103906)
2008
17
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. (17659871)
2007
18
Role for the Werner syndrome protein in the promotion of tumor cell growth. (17624410)
2007
19
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. (17715146)
2007
20
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains. (16503984)
2006
21
Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. (16720342)
2006
22
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. (16714450)
2006
23
In vivo prooxidant state in Werner syndrome (WS): results from three WS patients and two WS heterozygotes. (16036329)
2005
24
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. (15733840)
2005
25
Werner syndrome protein--unwinding function to explain disease. (15056797)
2004
26
A possible case of Werner syndrome presenting with multiple cancers. (15513515)
2004
27
Werner syndrome protein, the MRE11 complex and ATR: menage-A -trois in guarding genome stability during DNA replication? (14988932)
2004
28
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. (12944467)
2003
29
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent. (12881525)
2003
30
Werner syndrome protein contains three structure-specific DNA binding domains. (14534320)
2003
31
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. (14499497)
2003
32
Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases]. (11979727)
2002
33
Homologous recombination resolution defect in werner syndrome. (12242278)
2002
34
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. (11598021)
2001
35
Severe heart valve calcification in a young patient with Werner syndrome. (10739908)
2000
36
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases. (10782115)
2000
37
WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. (10811112)
2000
38
Functional interaction between Ku and the werner syndrome protein in DNA end processing. (10880505)
2000
39
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts. (10973920)
2000
40
Calcaneal osteosarcoma associated with Werner syndrome. A case report with mutation analysis. (11005522)
2000
41
The Werner syndrome protein is a DNA helicase. (9288107)
1997
42
Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome. (7545922)
1994
43
Werner syndrome and biological ageing: a molecular genetic hypothesis. (8357345)
1993
44
Werner Syndrome (20301687)
1993
45
Effect of insulin on the proline transport activity in cultured fibroblasts from patients with Werner syndrome. (1419149)
1992
46
Mutator phenotype of Werner syndrome is characterized by extensive deletions. (2762303)
1989
47
Histone H1 in G1 arrested, senescent, and Werner syndrome fibroblasts. (3909768)
1985
48
A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome. (3909767)
1985
49
Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts. (7327553)
1981
50

Variations for Werner Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Werner Syndrome:

67
id Symbol AA change Variation ID SNP ID
1WRNp.Lys125AsnVAR_026588
2WRNp.Lys135GluVAR_026589

Clinvar genetic disease variations for Werner Syndrome:

5 (show all 16)
id Gene Variation Type Significance SNP ID Assembly Location
1WRNNM_000553.4(WRN): c.561A> G (p.Lys187=)single nucleotide variantPathogenicrs775802030GRCh37Chr 8, 30924605: 30924605
2WRNNM_000553.4(WRN): c.487_488delGA (p.Asp163Cysfs)deletionLikely pathogenicrs797045118GRCh37Chr 8, 30922562: 30922563
3WRNNM_000553.4(WRN): c.2089-3024A> Gsingle nucleotide variantPathogenicrs281865157GRCh37Chr 8, 30966107: 30966107
4WRNNM_000553.4(WRN): c.2179dupT (p.Cys727Leufs)duplicationPathogenicrs281865158GRCh37Chr 8, 30969221: 30969221
5WRNNM_000553.4(WRN): c.3460-2A> Csingle nucleotide variantPathogenicrs281865159GRCh37Chr 8, 31004878: 31004878
6WRNNM_000553.4(WRN): c.3590delA (p.Asn1197Thrfs)deletionPathogenicrs281865160GRCh37Chr 8, 31007874: 31007874
7WRNNM_000553.4(WRN): c.3913C> T (p.Arg1305Ter)single nucleotide variantPathogenicrs121908446GRCh37Chr 8, 31014977: 31014977
8WRNNM_000553.4(WRN): c.3493C> T (p.Gln1165Ter)single nucleotide variantPathogenicrs121908447GRCh37Chr 8, 31004913: 31004913
9WRNNM_000553.4(WRN): c.3690_3693delAGAC (p.Asp1231Serfs)deletionPathogenicrs606231162GRCh38Chr 8, 31154626: 31154629
10WRNNM_000553.4(WRN): c.3139-1G> Csingle nucleotide variantPathogenicrs113993961GRCh37Chr 8, 30999196: 30999196
11WRNNM_000553.4(WRN): c.3915dupA (p.Ala1306Serfs)duplicationPathogenicrs587776621GRCh37Chr 8, 31014979: 31014979
12WRNNM_000553.4(WRN): c.1105C> T (p.Arg369Ter)single nucleotide variantPathogenicrs17847577GRCh37Chr 8, 30938648: 30938648
13WRNNM_000553.4(WRN): c.3686A> T (p.Gln1229Leu)single nucleotide variantPathogenicrs369158322GRCh38Chr 8, 31150454: 31150454
14WRNRECQL2, 1-BP DEL, NT1396deletionPathogenic
15WRNNM_000553.4(WRN): c.1730A> T (p.Lys577Met)single nucleotide variantPathogenicrs121908448GRCh37Chr 8, 30948359: 30948359
16WRNNM_000553.4(WRN): c.375A> T (p.Lys125Asn)single nucleotide variantPathogenicrs387906337GRCh37Chr 8, 30922450: 30922450

Expression for genes affiliated with Werner Syndrome

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Search GEO for disease gene expression data for Werner Syndrome.

Pathways for genes affiliated with Werner Syndrome

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Pathways related to Werner Syndrome according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
19.6MRE11A, NBN
29.3MRE11A, NBN, POLB
39.2MRE11A, NBN, XRCC5
4
Show member pathways
9.2MRE11A, NBN, XRCC5
5
Show member pathways
9.2BLM, PARP1, RPA1, WRN
6
Show member pathways
9.0EXO1, FEN1, RPA1
79.0BLM, MRE11A, NBN, RPA1
8
Show member pathways
9.0BLM, HELLS, MRE11A, NBN
9
Show member pathways
8.9FEN1, PARP1, POLB, RPA1, WRN
10
Show member pathways
8.8BLM, LMNA, MRE11A, NBN, RPA1
118.8BLM, MRE11A, NBN, WRN, XRCC5
128.7FEN1, MRE11A, NBN, WRN, XRCC5
13
Show member pathways
8.3BLM, EXO1, MRE11A, NBN, WRN
14
Show member pathways
8.2FEN1, MRE11A, NBN, PARP1, POLB, XRCC5
15
Show member pathways
8.0BLM, EXO1, MRE11A, NBN, RPA1, WRN
16
Show member pathways
8.0BLM, EXO1, MRE11A, NBN, RPA1, WRN
17
Show member pathways
8.0BLM, EXO1, MRE11A, NBN, RPA1, WRN
18
Show member pathways
7.4BLM, EXO1, FEN1, LMNA, MRE11A, NBN
19
Show member pathways
6.1BLM, EXO1, FEN1, MRE11A, NBN, PARP1

GO Terms for genes affiliated with Werner Syndrome

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Cellular components related to Werner Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:00166059.0BLM, MRE11A, NBN, RPA1

Biological processes related to Werner Syndrome according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1replication fork processingGO:003129710.5BLM, WRN
2DNA-dependent DNA replicationGO:000626110.5POLB, RPA1
3nucleotide-excision repair, DNA gap fillingGO:000629710.3POLB, RPA1
4nucleotide-excision repair, preincision complex stabilizationGO:000629310.2PARP1, RPA1
5positive regulation of kinase activityGO:003367410.2MRE11A, NBN
6mitotic G2 DNA damage checkpointGO:000709510.2MRE11A, NBN
7DNA duplex unwindingGO:003250810.2MRE11A, NBN
8nucleotide-excision repair, DNA incision, 5-to lesionGO:000629610.2PARP1, RPA1
9regulation of signal transduction by p53 class mediatorGO:190179610.1BLM, RPA1, WRN
10DNA damage response, detection of DNA damageGO:004276910.1PARP1, RPA1
11error-free translesion synthesisGO:007098710.0RPA1, VCP
12somatic hypermutation of immunoglobulin genesGO:001644610.0EXO1, POLB
13nucleotide-excision repair, preincision complex assemblyGO:000629410.0PARP1, RPA1
14positive regulation of protein autophosphorylationGO:00319549.9MRE11A, NBN
15nucleotide-excision repair, DNA incision, 3-to lesionGO:00062959.9PARP1, RPA1
16telomeric 3 overhang formationGO:00318609.8MRE11A, NBN
17DNA strand renaturationGO:00007339.8BLM, RECQL, RECQL4
18meiotic cell cycleGO:00513219.8EXO1, NBN
19base-excision repairGO:00062849.8RECQL4, RPA1, WRN
20DNA recombinationGO:00063109.4EXO1, WRN, XRCC5
21double-strand break repair via homologous recombinationGO:00007249.3BLM, PARP1, RECQL, RPA1, WRN
22DNA repairGO:00062819.2PARP1, RPA1, VCP
23cellular protein metabolic processGO:00442679.0BLM, LMNA, PARP1, RPA1, WRN
24double-strand break repair via synthesis-dependent strand annealingGO:00450038.7BLM, EXO1, MRE11A, NBN, WRN
25strand displacementGO:00007328.6BLM, EXO1, MRE11A, NBN, WRN
26nucleic acid phosphodiester bond hydrolysisGO:00903058.3EXO1, FEN1, MRE11A, WRN
27DNA replicationGO:00062608.1BLM, EXO1, MRE11A, NBN, RPA1, WRN
28cellular response to DNA damage stimulusGO:00069748.0BLM, MRE11A, NBN, PARP1, POLB, VCP

Molecular functions related to Werner Syndrome according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1four-way junction helicase activityGO:000937810.3RECQL, WRN
2exonuclease activityGO:000452710.0EXO1, WRN
35-3 exonuclease activityGO:00084099.8EXO1, FEN1
4ATP-dependent helicase activityGO:00080269.8BLM, RECQL4, WRN
5ATP-dependent DNA helicase activityGO:00040039.4MRE11A, RECQL, XRCC5
6DNA bindingGO:00036779.4BLM, RECQL, WRN, XRCC5
7catalytic activityGO:00038249.3BLM, EXO1, FEN1

Sources for Werner Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet