WRN
MCID: WRN001
MIFTS: 67

Werner Syndrome (WRN) malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Skin diseases, Fetal diseases

Aliases & Classifications for Werner Syndrome

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 27GTR, 31ICD10 via Orphanet, 37MedGen, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Werner Syndrome:

Name: Werner Syndrome 52 11 23 48 24 25 54 70 12 50 39 13 68
Werner's Syndrome 11 48 25
Adult Progeria 11 25 54
Ws 11 25 54
 
Werners Syndrome 25 27
Wrn 48 70
Adult Premature Ageing Syndrome 11
Adult Premature Aging Syndrome 25

Characteristics:

Orphanet epidemiological data:

54
werner syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Japan),1-9/100000; Age of onset: Adolescent,Adult

HPO:

64
werner syndrome:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 277700
Disease Ontology11 DOID:5688
MeSH39 D014898
NCIt45 C3447
Orphanet54 ORPHA902
MESH via Orphanet40 D014898
UMLS via Orphanet69 C0043119
ICD10 via Orphanet31 E34.8
MedGen37 C0043119

Summaries for Werner Syndrome

About this section
NIH Rare Diseases:48 Werner's syndrome is a disease chiefly characterized by premature aging and cancer predisposition. development is typically normal until the end of the first decade; the first sign is the lack of a growth spurt during puberty. early signs (usually in the 20s) include loss and graying of hair, hoarseness, and scleroderma-like skin changes, followed by cataracts, type 2 diabetes mellitus, hypogonadism, skin ulcers, and osteoporosis in the 30s. myocardial infarction (heart attack) and cancer are the most common causes of death, which typically occurs in the late 40s. it is caused by mutations in the wrn gene and is inherited in an autosomal recessive manner. management focuses on treatment of signs and symptoms and prevention of secondary complications. last updated: 4/29/2011

MalaCards based summary: Werner Syndrome, also known as werner's syndrome, is related to atypical werner syndrome and williams-beuren syndrome, and has symptoms including Array, Array and Array. An important gene associated with Werner Syndrome is WRN (Werner Syndrome RecQ Like Helicase), and among its related pathways are BARD1 signaling events and BRCA1 Pathway. Affiliated tissues include skin, heart and lung, and related mouse phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary.

Disease Ontology:11 An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is that has material basis in mutations in the WRN gene, on chromosome 8.

Genetics Home Reference:25 Werner syndrome is characterized by the dramatic, rapid appearance of features associated with normal aging. Individuals with this disorder typically grow and develop normally until they reach puberty. Affected teenagers usually do not have a growth spurt, resulting in short stature. The characteristic aged appearance of individuals with Werner syndrome typically begins to develop when they are in their twenties and includes graying and loss of hair; a hoarse voice; and thin, hardened skin. They may also have a facial appearance described as "bird-like." Many people with Werner syndrome have thin arms and legs and a thick trunk due to abnormal fat deposition.

UniProtKB/Swiss-Prot:70 Werner syndrome: A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction.

Wikipedia:71 Werner syndrome (WS), also known as \"adult progeria\", is a rare, autosomal recesive which is... more...

Description from OMIM:52 277700

GeneReviews for NBK1514

Related Diseases for Werner Syndrome

About this section

Diseases related to Werner Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1atypical werner syndrome12.0
2williams-beuren syndrome11.7
3waardenburg syndrome, type 2e, with or without neurologic involvement11.6
4hutchinson-gilford progeria11.2
5waardenburg syndrome, type 111.1
6waardenburg syndrome, type 311.0
7waardenburg syndrome, type 2a11.0
8waardenburg syndrome, type 4a11.0
9waardenburg's syndrome10.9
10waardenburg syndrome, type 2b10.8
11waardenburg syndrome, type 2c10.8
12waardenburg syndrome, type 2d10.8
13waardenburg syndrome, type 4b10.8
14waardenburg syndrome, type 4c10.8
15soft tissue sarcoma10.8
16uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis10.8
17autoimmune enteropathy10.2LMNA, WRN
18heart-hand syndrome, slovenian type10.2LMNA, WRN
19progeria10.2
20wolfram syndrome 210.1BLM, WRN
21mental retardation-hypotonic facies syndrome, x-linked10.0HELLS, NBN
22bile reflux9.9
23osteoporosis9.8
24ataxia-telangiectasia9.8
25bloom syndrome9.8
26ataxia9.8
27autoimmune disease 39.8RECQL, RECQL4, RECQL5, WRN
28breast cancer9.7
29coronary artery disease9.7
30rothmund-thomson syndrome9.7
31cataract9.7
32artery disease9.7
33sarcoma9.7
34hyperglycemia9.7
35thyroiditis9.7
36acrodermatitis enteropathica9.7HELLS, RECQL, RECQL4, RECQL5, WRN
37lymphedema-distichiasis syndrome9.6BLM, FEN1, HELLS, LMNA, NBN, PARP1
38baller-gerold syndrome9.6BLM, HELLS, RECQL, RECQL4, RECQL5, WRN
39colorectal cancer9.6
40lung cancer9.6
41hiv-19.6
42obesity9.6
43membranous nephropathy9.6
44chondrosarcoma9.6
45tangier disease9.6
46hypertriglyceridemia9.6
47pancreatic cancer9.6
48fragile x syndrome9.6
49atherosclerosis9.6
50ectodermal dysplasia9.6

Graphical network of the top 20 diseases related to Werner Syndrome:



Diseases related to werner syndrome

Symptoms & Phenotypes for Werner Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

277700

Clinical features from OMIM:

277700

Human phenotypes related to Werner Syndrome:

 54 64 (show all 65)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypogonadism64 54 Very frequent (99-80%) HP:0000135
2 convex nasal ridge64 54 Very frequent (99-80%) HP:0000444
3 cataract64 54 Very frequent (99-80%) HP:0000518
4 abnormality of the thorax64 54 Very frequent (99-80%) HP:0000765
5 osteoporosis64 54 Very frequent (99-80%) HP:0000939
6 slender build64 54 Very frequent (99-80%) HP:0001533
7 abnormality of the voice64 54 Very frequent (99-80%) HP:0001608
8 sparse scalp hair64 54 Very frequent (99-80%) HP:0002209
9 white forelock64 54 Very frequent (99-80%) HP:0002211
10 premature graying of hair64 54 Very frequent (99-80%) HP:0002216
11 pili torti64 54 Very frequent (99-80%) HP:0003777
12 short stature64 54 Very frequent (99-80%) HP:0004322
13 prematurely aged appearance54 Very frequent (99-80%)
14 abnormal hair whorl64 54 Very frequent (99-80%) HP:0010721
15 lipoatrophy64 54 Very frequent (99-80%) HP:0100578
16 abnormality of the testis54 Frequent (79-30%)
17 decreased fertility64 54 Frequent (79-30%) HP:0000144
18 narrow face64 54 Frequent (79-30%) HP:0000275
19 insulin resistance64 54 Frequent (79-30%) HP:0000855
20 chondrocalcinosis64 54 Frequent (79-30%) HP:0000934
21 hyperkeratosis64 54 Frequent (79-30%) HP:0000962
22 congestive heart failure64 54 Frequent (79-30%) HP:0001635
23 myocardial infarction64 54 Frequent (79-30%) HP:0001658
24 rocker bottom foot64 54 Frequent (79-30%) HP:0001838
25 atherosclerosis54 Frequent (79-30%)
26 skeletal muscle atrophy64 54 Frequent (79-30%) HP:0003202
27 pulmonary artery stenosis64 54 Frequent (79-30%) HP:0004415
28 type ii diabetes mellitus64 54 Frequent (79-30%) HP:0005978
29 subcutaneous calcification64 54 Frequent (79-30%) HP:0007618
30 abnormality of retinal pigmentation64 54 Frequent (79-30%) HP:0007703
31 aplasia/hypoplasia of the skin64 54 Frequent (79-30%) HP:0008065
32 lipodystrophy54 Frequent (79-30%)
33 aplasia/hypoplasia of the testes64 54 Frequent (79-30%) HP:0010468
34 increased bone mineral density64 54 Frequent (79-30%) HP:0011001
35 teleangiectasia of the skin54 Frequent (79-30%)
36 lack of skin elasticity64 54 Frequent (79-30%) HP:0100679
37 skin ulcer64 54 Frequent (79-30%) HP:0200042
38 small hand64 54 Frequent (79-30%) HP:0200055
39 hypertension64 54 Occasional (29-5%) HP:0000822
40 secondary amenorrhea64 54 Occasional (29-5%) HP:0000869
41 joint stiffness64 54 Occasional (29-5%) HP:0001387
42 laryngomalacia64 54 Occasional (29-5%) HP:0001601
43 neoplasm54 Occasional (29-5%)
44 gastrointestinal carcinoma64 54 Occasional (29-5%) HP:0002672
45 meningioma64 54 Occasional (29-5%) HP:0002858
46 squamous cell carcinoma64 54 Occasional (29-5%) HP:0002860
47 melanoma54 Occasional (29-5%)
48 thyroid carcinoma64 54 Occasional (29-5%) HP:0002890
49 breast carcinoma64 54 Occasional (29-5%) HP:0003002
50 renal neoplasm64 54 Occasional (29-5%) HP:0009726
51 cutaneous melanoma54 Occasional (29-5%)
52 acral lentiginous melanoma64 54 Occasional (29-5%) HP:0012060
53 sarcoma64 54 Occasional (29-5%) HP:0100242
54 neoplasm of the lung64 54 Occasional (29-5%) HP:0100526
55 ovarian neoplasm64 54 Occasional (29-5%) HP:0100615
56 neoplasm of the oral cavity64 54 Occasional (29-5%) HP:0100649
57 abnormality of the cerebral vasculature64 54 Occasional (29-5%) HP:0100659
58 neoplasm of the small intestine64 54 Occasional (29-5%) HP:0100833
59 retinal degeneration64 HP:0000546
60 diabetes mellitus64 HP:0000819
61 abnormality of the hair64 HP:0001595
62 osteosarcoma64 HP:0002669
63 premature arteriosclerosis64 HP:0005177
64 progeroid facial appearance64 HP:0005328
65 telangiectasia of the skin64 HP:0100585

GenomeRNAi Phenotypes related to Werner Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-36.6BLM, EXO1, FEN1, NBN, PARP1, RECQL

MGI Mouse Phenotypes related to Werner Syndrome according to GeneCards Suite gene sharing:

41 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.4FEN1, LMNA, POLB, RECQL4, WRN, XRCC5
2MP:00053808.4BLM, FEN1, HELLS, NBN, PARP1, POLB
3MP:00053798.2EXO1, FEN1, HELLS, LMNA, NBN, POLB
4MP:00020067.7BLM, EXO1, FEN1, NBN, RECQL4, RPA1
5MP:00107717.5BLM, HELLS, LMNA, PARP1, POLB, RECQL4
6MP:00053786.9BLM, FEN1, HELLS, LMNA, NBN, PARP1
7MP:00053766.9EXO1, FEN1, HELLS, LMNA, NBN, PARP1
8MP:00107686.0BLM, EXO1, FEN1, HELLS, LMNA, NBN
9MP:00053845.7BLM, EXO1, FEN1, HELLS, LMNA, NBN
10MP:00053975.6BLM, EXO1, FEN1, HELLS, LMNA, NBN
11MP:00053875.6BLM, EXO1, FEN1, HELLS, LMNA, NBN

Drugs & Therapeutics for Werner Syndrome

About this section

Drugs for Werner Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 382)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethyltestosteroneapprovedPhase 4, Phase 3, Phase 256358-18-46010
Synonyms:
17(alpha)-Methyl-delta(4)-androsten-17(beta)-ol-3-one
17-Methyltestosterone
17-beta-Hydroxy-17-methylandrost-4-en-3-one
17-methyltestosterone
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
17alpha-Methyl-delta(4)-androsten-17beta-ol-3-one
17alpha-Methyltestosterone
17alpha-methyl-delta-androsten-17beta-ol-3-one
17alpha-methyltestosterone
 
17beta-Hydroxy-17-methylandrost-4-en-3-one
17α-methyl-Δ4-androsten-17β-ol-3-one
17α-methyltestosterone
4-Androstene-17alpha-methyl-17beta-ol-3-one
Android
Methyltestosterone
Methyltestosteronum
Metiltestosterona
NSC-9701
Testred
Virilon
2
Testosteroneapproved, investigationalPhase 4, Phase 3, Phase 256358-22-06013
Synonyms:
(+)-testosterone
(+-)-8-iso-testosterone
(+-)-retrotestosterone
(+-)-testosterone
(17b)-17-hydroxy-androst-4-en-3-one
(17beta)-17-Hydroxyandrost-4-en-3-one
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
13-Iso-testosterone
17-Hydroxy-(17-beta)-androst-4-en-3-one
17-Hydroxy-(17beta)-androst-4-en-3-one
17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
17-Hydroxy-D4-androsten-3-one
17-Hydroxy-androst-4-en-3-one
17-beta-Hydroxy-delta(sup 4)-androsten-3-one
17-beta-Hydroxyandrost-4-en-3-one
17?-Hydroxy-4-androsten-3-one
17a-Hydroxy-(13a)-androst-4-en-3-one
17a-Hydroxy-13a-androst-4-en-3-one
17a-Hydroxy-14b-androst-4-en-3-one
17a-Hydroxy-androst-4-en-3-one
17b-Hydroxy-(10a)-androst-4-en-3-one
17b-Hydroxy-(13a)-androst-4-en-3-one
17b-Hydroxy-(8a)-androst-4-en-3-one
17b-Hydroxy-(8a,10a)-androst-4-en-3-one
17b-Hydroxy-(9b)-androst-4-en-3-one
17b-Hydroxy-(9b,10a)-androst-4-en-3-one
17b-Hydroxy-13a-androst-4-en-3-one
17b-Hydroxy-8a-androst-4-en-3-one
17b-Hydroxy-D4-androsten-3-one
17b-Hydroxy-androst-4-en-3-on
17b-Hydroxy-androst-4-en-3-one
17b-Hydroxyandrost-4-en-3-one
17b-Hydroxyandrost-4-ene-3-one
17b-Testosterone
17b-hydroxy-4-androsten-3-one
17beta-Hydroxy-3-oxo-4-androstene
17beta-Hydroxy-4-androsten-3-one
17beta-Hydroxy-delta(sup4)-androsten-3-one
17beta-Hydroxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-ene-3-one
17beta-hydroxy-4-androsten-3-one
4-Androsten-17?-ol-3-one
4-Androsten-17beta-ol-3-one
4-Androsten-3-one-17b-ol
4-androsten-17β-ol-3-one
4-androstene-17beta-ol-3-one
46923_FLUKA
46923_RIEDEL
58-22-0
7-beta-Hydroxyandrost-4-en-3-one
8-Iso-testosterone
9b,10a-Testosterone
9b-Testosterone
AA 2500
AC-14899
AC1L1LM0
Andriol
Andro
Andro 100
Andro L.A. 200
AndroGel
Androderm
Androderm (TN)
Androgel
Androgel (TN)
Android 10
Android 25
Android 5
Androlin
Andronaq
Andronate 100
Andronate 200
Andropatch
Andropository 200
Androsorb
Androst-4-en-17b-ol-3-one
Androst-4-en-17beta-ol-3-one
Androst-4-ene-17b-ol-3-one
Andrusol
Andryl 200
B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E
BIDD:ER0555
BIM-0061761.0001
Beta Testosterone
Bio-0678
Bio-T-Gel
C00535
CCRIS 574
CDB 111C
CHEBI:17347
CHEMBL386630
CID6013
CMC_13449
COL 1621
CP 601B
CPD000058344
Cristerona T
Cristerone T
D00075
D4-Androsten-17b-ol-3-one
DB00624
Dea No. 4000
Delatest
Delatestryl
Depo-Testadiol
Depo-Testosterone
Depo-Testosterone Cypionate
Depotest
EINECS 200-370-5
Epitestosteron
Everone 200
Geno-Cristaux Gremy
Geno-cristaux Gremy
Geno-cristaux gremy
HMS2052N11
HSDB 3398
Halotensin
Homosteron
Homosterone
 
Intrinsa
LMST02020002
LS-148813
LibiGel
Libigel
Lumitestosteron
MLS000563091
MLS001032098
MLS001306401
MLS002174283
Malerone
Malestrone
Malestrone (amps)
Malogen in Oil
Malogen, Aquaspension Injection
Malogen, aquaspension injection
Mertestate
Metandren
Methyltestosterone
MolPort-002-506-901
NCGC00091018-01
NSC 9700
Neo-Hombreol F
Neo-Testis
Neo-testis
Neotestis
Oreton
Oreton F
Oreton Methyl
Oreton-F
Orquisteron
Perandren
Percutacrine Androgenique
Percutacrine androgenique
Primotest
Primoteston
Rac-17b-hydroxy-(13a)androst-4-en-3-one
Rac-17b-hydroxy-(8a)-androst-4-en-3-one
Rac-17b-hydroxy-(9b,10a)androst-4-en-3-one
Rac-17b-hydroxy-androst-4-en-3-one
Relibra
Retrotestosterone
S00309
S2033_Selleck
SAM001246921
SMR000058344
SMR001261453
Scheinpharm Testone-Cyp
Striant
Striant (TN)
Sustanon
Sustanone
Sustason 250
Synandrol F
T-Cypionate
T1500_SIGMA
T5411_FLUKA
T5411_SIGMA
TES
Teslen
Testamone 100
Testandrone
Testaqua
Testiculosterone
Testim
Testim (TN)
Testobase
Testoderm
Testoderm Tts
Testogel
Testoject-50
Testolent
Testolin
Testopel Pellets
Testopropon
Testosteroid
Testosteron
Testosterona
Testosterona [INN-Spanish]
Testosterone
Testosterone (JAN/USP)
Testosterone Cypionate
Testosterone Enanthate
Testosterone Hydrate
Testosterone [Androgenic steroids, anabolic]
Testosterone [INN:BAN]
Testosterone and its esters
Testosterone hydrate
Testosterone solution
Testosteronum
Testosteronum [INN-Latin]
Testostosterone
Testostérone
Testoviron
Testoviron Schering
Testoviron T
Testoxyl
Testred
Testred Cypionate 200
Testrin-P.A
Testro AQ
Testro Aq
Testrone
Testryl
Tostrelle
Tostrex
Trans-Testosterone
UNII-3XMK78S47O
Viatrel
Virilon
Virilon IM
Virormone
Virosterone
ZINC06500184
beta testosterone
delta(sup 4)-Androsten-17(beta)-ol-3-one
delta4-Androsten-17beta-ol-3-one
delta4-androsten-17b-ol-3-one
testosterone
trans-Testosterone
3
Furosemideapproved, vet_approvedPhase 419354-31-93440
Synonyms:
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
41733-55-5 (mono-hydrochloride salt)
5-18-09-00555 (Beilstein Handbook Reference)
54-31-9
AB00052001
AC-11067
AC1L1FXW
AC1Q557O
AKOS000266625
ARONIS24304
Acetic acid potassium salt
Aisemide
Aldalix
Aldic
Aluzine
Anfuramaide
Apo-Frusemide
Apo-Furosemide
Aquarid
Aquasin
Arasemide
BIDD:GT0139
BPBio1_000443
BRD-K78010432-001-05-8
BRN 0840915
BSPBio_000401
BSPBio_002054
Beronald
Bio-0044
Bioretic
Bristab
Bristurin
C12H11ClN2O5S
CAS-54-31-9
CCRIS 1951
CHEBI:47426
CHEMBL35
CID3440
CPD000058202
Cetasix
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]
D00331
D005665
DB00695
DB07799
Depix
Desal
Desdemin
Di-Ademil
Dihydroflumethiazide
Dirine
Disal
Discoid
Disemide
Diucardin
Diumide-K
Diural
Diurapid
Diuretic Salt
Diuretic salt
Diurin
Diurolasa
Diusemide
Diusil
Diuzol
DivK1c_000575
Dranex
Dryptal
Durafurid
EINECS 200-203-6
Edemid
Edenol
Eliur
Elodrine
Endural
Errolon
Eutensin
F0182
F4381_SIGMA
FUN
FUROSEMIDE USP
Farsix
Finuret
Fluidrol
Fluss
Franyl
Frumex
Frumide
Frumil
Frusedan
Frusema
Frusemid
Frusemide
Frusemin
Frusenex
Frusetic
Frusid
Fu sid
Fulsix
Fuluvamide
Fuluvamine
Furanthril
Furanthryl
Furantral
Furantril
Furanturil
Furesis
Furetic
Furex
Furfan
Furix
Furmid
Furo-Basan
Furo-Puren
Furo-puren
Furobeta
Furocot
Furodiurol
Furodrix
Furomen
Furomex
Furomide M.D
Furomide M.D.
Furorese
Furosan
Furose
Furosedon
Furosemid
Furosemida
Furosemida [INN-Spanish]
Furosemide
Furosemide "mita"
Furosemide (JP15/USP/INN)
Furosemide Monohydrochloride
Furosemide Monosodium Salt
Furosemide [USAN:INN:JAN]
Furosemidu
Furosemidu [Polish]
Furosemidum
Furosemidum [INN-Latin]
Furosemix
Furoside
Furosifar
Furosix
Furoter
Furovite
Fursemid
Fursemida
Fursemide
Fursol
Fusid
Fusidic acid
 
Golan
HMS1569E03
HMS1920B03
HMS2090K06
HMS2091H05
HMS501M17
HSDB 3086
Hissuflux
Hoe-058A
Hydol
Hydrenox
Hydrex
Hydro
Hydro-Rapid
Hydro-rapid
Hydroled
I04-0179
IDI1_000575
Impugan
Jenafusid
KBio1_000575
KBio2_001580
KBio2_004148
KBio2_006716
KBio3_001274
KBioGR_001259
KBioSS_001580
Katlex
Kofuzon
Kolkin
Kutrix
LB 502
LB-502
LS-204
Lasemid
Lasex
Lasiletten
Lasilix
Lasix
Lasix (TN)
Lasix (tn)
Lasix Retard
Lasix Special
Lasix, Frusemide, Furosemide
Laxur
Lazix
Leodrine
Less Diur
Liside
Logirene
Lowpston
Lowpstron
Luscek
MLS001066374
MLS001306403
Macasirool
Marsemide
Metflorylthiazidine
Methforylthiazidine
Mirfat
Mita
Moilarorin
MolPort-001-641-065
Myrosemide
NCGC00016241-01
NCGC00090893-01
NCGC00090893-02
NCGC00090893-03
NCGC00090893-05
NCGC00090893-06
NCI-C55936
NINDS_000575
NSC 269420
NSC269420
Nadis
Nelsix
Neo-Renal
Neo-renal
Nephron
Nicorol
Novosemide
Octan Draselny
Octan draselny
Odemase
Odemex
Oedemex
Olmagran
Oprea1_667724
Osyrol
Polysquall A
Prefemin
Prestwick0_000341
Prestwick1_000341
Prestwick2_000341
Prestwick3_000341
Prestwick_752
Profemin
Promedes
Promide
Protargen
Puresis
Radisemide
Radonna
Radouna
Retep
Rodiuran
Rontyl
Rosemide
Rosis
Rusyde
S1603_Selleck
SAM002264614
SMP1_000129
SMR000058202
SPBio_001129
SPBio_002322
SPECTRUM1500310
STK177334
Sal Diureticum
Sal diureticum
Salinex
Salix
Salix (brand of furosemide)
Salurex
Salurid
Saluron
Seguril
Selectofur
Sigasalur
Sisuril
Spectrum2_001005
Spectrum3_000437
Spectrum4_000560
Spectrum5_000744
Spectrum_001100
Spirofur
Synephron
TL8003563
Transit
Trofurit
UNII-7LXU5N7ZO5
UPCMLD-DP022
UPCMLD-DP022:001
Uremide
Uresix
Urex
Urex-M
Urian
Uridon
Uritol
Urosemide
Vergonil
Vesix
WLN: T5OJ B1MR CG FVQ DSZW
Yidoli
Zafimida
fulvamide
furosemide
furosemide ''mita''
less Diur
4
Heparinapproved, investigationalPhase 48489005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
5
ApixabanapprovedPhase 4, Phase 3154503612-47-310182969
Synonyms:
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahyd
2p16
503612-47-3
AKOS005146204
Apixaban
Apixaban (JAN/USAN/INN)
BMS 562247-01
BMS-562247
BMS-562247-01
BMS-562247-01, Apixaban
 
CHEBI:49620
CHEMBL231779
CID10182969
D03213
DB07828
GG2
S1593_Selleck
UNII-3Z9Y7UWC1J
apixabanum
apixabán
ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide
6
LevobupivacaineapprovedPhase 417227262-47-192253
Synonyms:
(-)-Bupivacaine
(-)-bupivacaine
(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(S)-1-Butyl-2',6'-pipecoloxylidide
(S)-Bupivacaine
(S)-bupivacaine
27262-47-1
27262-48-2
AC1L3NQM
BIDD:GT0471
C07887
C18H28N2O
CAS-18010-40-7
CHEBI:6149
CID92253
D08116
 
DB01002
L(-)-Bupivacaine
L-(-)-1-Butyl-2',6'-pipecoloxylidide
L-(-)-Bupivacaine
L-(-)-bupivacaine
LS-109843
LS-187025
LS-187789
Levobupivacaine
Levobupivacaine (INN)
Levobupivacaine [INN:BAN]
Levobupivacaine hydrochloride
MolPort-004-959-713
NCGC00016733-01
NCGC00159482-02
Novabupi
Novabupi (TN)
7
DopamineapprovedPhase 4, Phase 2383651-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
8
Bupivacaineapproved, investigationalPhase 4, Phase 3, Phase 112332180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
9
Zoledronic acidapprovedPhase 4294118072-93-868740
Synonyms:
(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
(1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate
(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
118072-93-8
2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
AC-1092
AC1L2ACJ
AC1Q6RN3
AKOS005145739
Aclasta
Anhydrous Zoledronic Acid
BIDD:GT0292
BIDD:PXR0134
Bio-0112
Bisphosphonate 3
C088658
CGP 42'446
CGP 42446
CGP 42446A
CGP-42'446
CGP-42446
CHEBI:46557
CHEMBL924
CID68740
D08689
DB00399
 
FT-0082657
HMS2089O09
I06-0710
KS-1132
LS-181815
MolPort-002-885-874
MolPort-003-850-890
NCGC00159521-02
NCGC00159521-03
NSC721517
Novartis brand of zoledronic acid
Reclast
Reclast (TN)
S00092
S1314_Selleck
UNII-70HZ18PH24
ZOL
Zol
Zoledronate
Zoledronic Acid Anhydrous
Zoledronic Acid, Anhydrous
Zoledronic acid
Zoledronic acid (INN)
Zoledronic acid [USAN:INN]
Zometa
Zometa (Novartis)
Zometa (TN)
Zometa Concentrate
Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid
[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
10
WarfarinapprovedPhase 447081-81-26691, 54678486
Synonyms:
(-)-Warfarin
(S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
(S)-Warfarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
200 Coumarin
200 coumarin
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin
3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3- (3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3- (3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
4-Idrossi-3- (3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine
45706_FLUKA
45706_RIEDEL
4oh-coumarin deriv.
5543-56-6
5543-57-7
81-81-2
A2250_FLUKA
A2250_SIGMA
AC-15978
AC1L1N37
AC1Q6AN3
AR-1E2310
Arab Rat Death
Arab rat death
Arab rat deth
Athrombin
Athrombin-K
Athrombin-k
Athrombine-K
Athrombine-k
BRD-A24514565-001-02-2
BRD-A24514565-236-01-6
BRN 1293536
BSPBio_002026
Bio-0586
Brumolin
C01541
C19H16O4
CBDivE_002127
CBDivE_013236
CBKinase1_000192
CBKinase1_012592
CHEBI:10033
CHEMBL1464
CID6691
CO-Rax
Caswell No. 903
Choice
Choice (TN)
Co-Rax
Co-rax
Compound 42
Coumadin
Coumadin Tabs
Coumafen
Coumafene
Coumafene [French]
Coumaphen
Coumaphene
Coumarins
Coumefene
Cov-R-Tox
Cov-R-tox
D-Con
D08682
DB00682
DL-3-(alpha-acetonylbenzyl)-4-hydroxycoumarin
Dethmor
Dethnel
Dicusat E
Dicusat e
DivK1c_000444
EINECS 201-377-6
EINECS 226-907-3
EPA Pesticide Chemical Code 086002
Eastern states duocide
Fasco fascrat powder
Frass-Ratron
Frass-ratron
HMS1921K07
HMS2092C20
HMS501G06
HSDB 1786
I14-0958
IDI1_000444
Jantoven
KBio1_000444
KBio2_000674
KBio2_003242
KBio2_005810
KBio3_001526
KBioGR_000901
KBioSS_000674
Killgerm sewarin p
Kumader
Kumadu
Kumatox
Kypfarin
LS-55083
Latka 42
Latka 42 [Czech]
Liqua-tox
MLS001304042
Maag Rattentod Cum
Maag rattentod cum
Mar-Frin
Mar-frin
Marevan
Martin'S mar-frin
Martin's mar-frin
 
Maveran
MolPort-001-787-822
Mouse pak
NCGC00094810-01
NCGC00094810-02
NCGC00159398-03
NCGC00178855-01
NINDS_000444
NSC 59813
NSC59813
PS104_SUPELCO
Panwarfin
Place-Pax
Place-pax
Prothromadin
RAX
RCR grey squirrel killer concentrate
RCRA waste no. P001
Rat & mice bait
Rat and mice bait
Rat-B-gon
Rat-Gard
Rat-Kill
Rat-Mix
Rat-O-cide #2
Rat-O-cide no. 2
Rat-Ola
Rat-Trol
Rat-a-way
Rat-alpha-way
Rat-b-gon
Rat-beta-gon
Rat-gard
Rat-kill
Rat-mix
Rat-o-cide #2
Rat-ola
Rat-trol
Ratorex
Ratox
Ratoxin
Ratron
Ratron G
Ratron g
Rats-no-more
Ratten-Koederrohr
Ratten-koederrohr
Rattenstreupulver Neu Schacht
Rattenstreupulver neu schacht
Rattenstreupulver new schacht
Rattentraenke
Rattunal
Rcra waste number P001
Ro-Deth
Ro-deth
Rodafarin
Rodafarin C
Rodafarin c
Rodex
Rodex blox
Rosex
Rough & ready mouse mix
Rough and ready mouse mix
SMP1_000316
SMR000718754
SPBio_000870
SPECTRUM1500613
STK364490
Sakarat
Sewarin
Sofarin
Solfarin
Sorexa Plus
Sorexa plus
Spectrum2_000935
Spectrum3_000583
Spectrum4_000381
Spectrum5_001751
Spectrum_000194
Spray-trol brand roden-trol
Temus W
Temus w
Tintorane
Tox-Hid
Tox-hid
Twin light rat away
UNII-5Q7ZVV76EI
Vampirinip II
Vampirinip III
Vampirinip iii
W.A.R.F. 42
WARF compound 42
WLN: T66 BOVJ DYR&1V1 EQ
Waran
Warf 10
Warf 42
Warfarat
Warfarin (INN)
Warfarin (and salts of)
Warfarin Plus
Warfarin Q
Warfarin [BSI:ISO]
Warfarin [INN:BAN]
Warfarin plus
Warfarin plus [discontinued]
Warfarin sodium
Warfarin titrated to an INR of 2.5-3.0
Warfarin(R)
Warfarina
Warfarina [INN-Spanish]
Warfarine
Warfarine [INN-French]
Warfarine [ISO-French]
Warfarinum
Warfarinum [INN-Latin]
Warficide
Warfilone
Zoocoumarin
Zoocoumarin [Netherlands and USSR]
Zoocoumarin [Russian]
delta-Con
nchembio.307-comp19
rac-Warfarin
warfarin
11
Esomeprazoleapproved, investigationalPhase 4333161796-78-7, 119141-88-74594, 9579578
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(-)-omeprazole
(S)-(-)-Omeprazole
(S)-(−)-omeprazole
(S)-Omeprazole
(S)-omeprazole
(s)-omeprazole
(−)-omeprazole
119141-88-7
119141-89-8
131959-78-9
172964-80-6
193469-77-1
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
326602-80-6
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1-methyl-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Axagon
BIDD:GT0020
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:50275
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CID9568614
CID9579578
CPD000058847
Ceprandal
D00455
D07917
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazol
Esomeprazole
Esomeprazole (INN)
Esomeprazole Sodium
Esomeprazole [INN:BAN]
Esomeprazolum
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20
Indurgan
Inexium paranova
Inexium paranova (TN)
Inhibitron
Inhipump
LS-185188
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
 
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
MolPort-005-943-880
Mopral
Morecon
NCGC00016925-01
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium Control
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole (JAN/USP/INN)
Omeprazole S-form
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Perprazole
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UNII-N3PA6559FT
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
ZINC04693574
ZINC04693575
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
esomeprazole
esomeprazolum
omeprazole
Ésoméprazole
12
Prednisoneapproved, vet_approvedPhase 4, Phase 2139853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
13
PantoprazoleapprovedPhase 4175102625-70-74679
Synonyms:
102625-70-7
5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole
5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
AC-679
AC1L1IPJ
Astropan
BIDD:GT0003
BRD-A22380646-001-01-5
BSPBio_002320
BY 1023
BY-1023
C11806
C16H15F2N3O4S
CHEBI:519598
CHEBI:7915
CHEMBL1502
CID4679
D05353
DB00213
HMS1922H20
HMS2090H03
HMS2093F14
HSDB 7292
I06-0068
LS-32883
MolPort-003-666-752
MolPort-005-933-577
NCGC00095188-01
 
NCGC00095188-02
NCGC00095188-03
Pantoloc
Pantopan
Pantoprazol
Pantoprazol [INN-Spanish]
Pantoprazole (USAN/INN)
Pantoprazole Na
Pantoprazole Sodium
Pantoprazole Sodium Hydrate
Pantoprazole [USAN:BAN:INN]
Pantoprazole sodium
Pantoprazolum
Pantoprazolum [INN-Latin]
Pantoprozole
Pantor
Pantozol
Protium
Protonix
Protonix I.V.
Protonix IV
SBB070993
SK&F 96022
SK&F-96022
SK-96022
SKF-96022
SPECTRUM1505818
Somac
TL8000127
UNII-D8TST4O562
pantoprazole
14
VerapamilapprovedPhase 413052-53-92520
Synonyms:
(+-)-Verapamil
(+/-)-VERAPAMIL
(1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
52-53-9
56949-77-0
AB00053495
AC-16016
AC1L1DV5
Akilen
Anpec
Apo-Verap
Arpamyl
Arpamyl LP
BPBio1_000268
BRD-A09533288-001-02-7
BRD-A09533288-003-05-6
BSPBio_000242
BSPBio_001513
BSPBio_002358
Berkatens
Bio-0754
Bio1_000425
Bio1_000914
Bio1_001403
Bio2_000233
Bio2_000713
C07188
C27H38N2O4
CCRIS 6749
CHEBI:9948
CHEMBL6966
CID2520
CP-16533-1
CP-165331
Calan
Calan SR
Calan sr
Calaptin
Calaptin 240 SR
Calcan
Cardiabeltin
Cardiagutt
Cardibeltin
Cardioprotect
Caveril
Civicor
Civicor Retard
Coraver
Cordilox
Cordilox SR
Corpamil
Covera-HS
Covera-Hs
Covera-hs
D-365
D02356
DB00661
Dexverapamil
Dignover
Dilacoran
Dilacoran HTA
DivK1c_000399
Drosteakard
Durasoptin
EINECS 200-145-1
EINECS 260-462-6
Elthon
FT-0080127
Falicard
Finoptin
Flamon
Geangin
HMS1791L15
HMS1989L15
HMS2089H17
Harteze
Hexasoptin
Hexasoptin Retard
Hormitol
I06-0063
IDI1_000399
IDI1_033983
Ikacor
Ikapress
Inselon
Iproveratril
Isoptimo
Isoptin
Isoptin Retard
Isoptin SR
Isoptin sr
Isoptine
Isoptino
Isotopin
Izoptin
Jenapamil
KBio1_000399
KBio2_000233
KBio2_002343
KBio2_002801
KBio2_004911
KBio2_005369
KBio2_007479
KBio3_000465
KBio3_000466
 
KBio3_002823
KBioGR_000233
KBioGR_001372
KBioGR_002343
KBioSS_000233
KBioSS_002346
L001330
LS-174
Lekoptin
Lodixal
Lopac0_001237
Magotiron
Manidon
Manidon Retard
MolPort-000-721-258
NCGC00016083-14
NCGC00024710-04
NCGC00024710-05
NCGC00024710-06
NCGC00024710-07
NCGC00024710-08
NCGC00024710-09
NCI60_020143
NINDS_000399
NSC272366
NU-Verap
Novapamyl LP
Novo-Veramil
Nu-Verap
Ormil
Praecicor
Prestwick0_000141
Prestwick1_000141
Prestwick2_000141
Prestwick3_000141
Quasar
Rapam
Robatelan
SPBio_001820
SPBio_002181
STK538085
Securon
Spectrum2_001740
Spectrum4_000906
Spectrum5_001786
Tarka
UNII-CJ0O37KU29
Univer
Univex
VERAPAMIL
Vasolan
Vasomil
Vasopten
Vera-Sanorania
Verabeta
Veracaps SR
Veracim
Veracor
Verahexal
Veraloc
Veramex
Veramil
Verapamil
Verapamil (USAN/INN)
Verapamil AL
Verapamil Acis
Verapamil Atid
Verapamil Basics
Verapamil Ebewe
Verapamil HCl
Verapamil Henning
Verapamil Injection
Verapamil MSD
Verapamil NM
Verapamil NM Pharma
Verapamil Nordic
Verapamil PB
Verapamil Riker
Verapamil SR
Verapamil Verla
Verapamil [USAN:BAN:INN]
Verapamil [USAN:INN:BAN]
Verapamil [Usan:Ban:Inn]
Verapamil-AbZ
Verapamilo
Verapamilo [INN-Spanish]
Verapamilum
Verapamilum [INN-Latin]
Verapin
Verapress 240 SR
Veraptin
Verasal
Verasifar
Veratensin
Verdilac
Verelan
Verelan PM
Verelan SR
Verexamil
Veroptinstada
Verpamil
Vetrimil
Vortac
Vérapamil
alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
cMAP_000023
delta-365
nchembio.368-comp2
nchembio.79-comp5
15
NifedipineapprovedPhase 411821829-25-44485
Synonyms:
101539-70-2
101554-38-5
21829-25-4
4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester
5-22-04-00268 (Beilstein Handbook Reference)
60299-11-8 (mono-hydrochloride)
AC-11618
AC1L1I9V
AC1Q4254
AKOS002942507
ARONIS24171
AWD Pharma Brand of Nifedipine
Adalat
Adalat (TN)
Adalat 10
Adalat 20
Adalat 5
Adalat CC
Adalat CR
Adalat Crono
Adalat FT
Adalat Ft
Adalat GITS
Adalat GITS 30
Adalat Gits
Adalat Gits 30
Adalat LA
Adalat LP
Adalat Oros
Adalat PA
Adalat Retard
Adalat XL
Adalate
Adalate LP
Adapine
Adapress
Adcock Ingram Brand of Nifedipine
Adipine XL
Afeditab
Afeditab CR
Afeditab CR (TN)
Alat
Aldipin
Alfadal
Alonix
Alonix S
Alpha-Nifedipine Retard
Angipec
Anifed
Anpine
Apo-Nifed
Aprical
Aprical long
BAY 1040
BAY A 1040
BAY-a 1040
BAYa1040
BCBcMAP01_000046
BIDD:GT0442
BIDD:PXR0034
BIM-0050796.0001
BPBio1_000271
BRN 0497773
BSPBio_000245
BSPBio_001391
BSPBio_002071
Bay-1040
Bay-a-1040
Bay1040
Bayer Brand of Nifedipine
Bio-0733
Bio1_000112
Bio1_000601
Bio1_001090
Bio2_000111
Bio2_000591
Bonacid
C07266
C17H18N2O6
CAS-21829-25-4
CBiol_001826
CCRIS 6074
CHEBI:7565
CHEMBL193
CID4485
CPD000058291
Calcibloc
Calcigard
Calcilat
Camont
Cardifen
Cardilat
Cardionorm
Chronadalate
Chronadalate LP
Chronadalate Lp
Citilat
Coracten
Coracten XL
Coral
Cordafen
Cordaflex
Cordalat
Cordicant
Cordilan
Cordipin
Cordipine
Corinfar
Corotrend
Corynphar
D00437
D009543
DB01115
Depin
Dignokonstant
Dilafed
Dilcor
Dipinkor
DivK1c_000313
Duranifin
EINECS 244-598-3
EU-0100819
Ecodipi
Ecodipin
Ecodipin E
Emaberin
Fedcor
Fedcor Retard
Fenamon
Fenamon SR
Fenamon Sr
Fenigidin
Fenihidin
Fenihidine
Fortipine LA
Glopir
HMS1361F13
HMS1568M07
HMS1791F13
HMS1920P19
HMS1989F13
HMS2051O03
HMS2089H11
HMS2091H20
 
HMS500P15
Hadipin
Hexadilat
I06-0051
I06-1286
IDI1_000313
IDI1_033861
Infedipin
Introcar
KB-1712P
KBio1_000313
KBio2_000111
KBio2_001459
KBio2_002400
KBio2_002679
KBio2_004027
KBio2_004968
KBio2_005247
KBio2_006595
KBio2_007536
KBio3_000221
KBio3_000222
KBio3_001571
KBio3_002879
KBioGR_000111
KBioGR_000627
KBioGR_002400
KBioSS_000111
KBioSS_001459
KBioSS_002405
KRKA Brand of Nifedipine
Kordafen
Korinfar
L001054
LS-1012
Lopac-N-7634
Lopac0_000819
MLS000028521
MLS000758222
MLS001148146
MLS001401371
Macorel
Megalat
MolPort-000-787-707
MolPort-006-822-492
Monohydrochloride, Nifedipine
Myogard
N 7634
N0528
N1fedilat
N7634_SIGMA
NCGC00015748-01
NCGC00015748-02
NCGC00015748-03
NCGC00015748-06
NCGC00015748-13
NCGC00024983-01
NCGC00024983-02
NCGC00024983-03
NCGC00024983-04
NCGC00024983-05
NCGC00024983-06
NCGC00024983-07
NCGC00024983-08
NCGC00091707-01
NINDS_000313
Nedipin
Nicardia
Nifangin
Nifar
Nifdemin
Nifebene
Nifecard
Nifecor
Nifedepat
Nifediac
Nifedical
Nifedical XL
Nifedicor
Nifedin
Nifedine
Nifedipine
Nifedipine (JP15/USP/INN)
Nifedipine Bayer Brand
Nifedipine GTIS
Nifedipine KRKA Brand
Nifedipine Monohydrochloride
Nifedipine Orion Brand
Nifedipine Pfizer Brand
Nifedipine Retard
Nifedipine [USAN:BAN:INN:JAN]
Nifedipine-GTIS
Nifedipino
Nifedipino [INN-Spanish]
Nifedipinum
Nifedipinum [INN-Latin]
Nifedipres
Nifedirex LP
Nifelan
Nifelat
Nifelat Q
Nifelate
Nifensar XL
Nificard
Nifidine
Nifipen
Niphedipine
Oprea1_788617
Orion Brand of Nifedipine
Orix
Oxcord
Pfizer Brand of Nifedipine
Pidilat
Prestwick0_000063
Prestwick1_000063
Prestwick2_000063
Prestwick3_000063
Prestwick_357
Procardia
Procardia (TN)
Procardia XL
S1808_Selleck
SAM001246963
SMR000058291
SPBio_001016
SPBio_002166
SPECTRUM1500431
STK735567
Sepamit
Slofedipine XL
Spectrum2_001058
Spectrum3_000516
Spectrum4_000074
Spectrum5_001278
Spectrum_000979
Tensipine MR
Tibricol
Tocris-1075
UNII-I9ZF7L6G2L
Vascard
ZINC19594578
Zenusin
cMAP_000042
nchembio.95-comp13
nifedipine
16
LabetalolapprovedPhase 43636894-69-63869
Synonyms:
2-Hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)benzamide
2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
36894-69-6
5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
AB00053659
AC-18747
AC1L1GW8
AH 5158
AH-5158
Albetol
BPBio1_000170
BRD-A07440155-003-05-6
BSPBio_000154
BSPBio_003142
C07063
CHEBI:6343
CHEMBL429
CID3869
D08106
DB00598
DivK1c_000474
EINECS 253-258-3
HSDB 6537
IDI1_000474
Ibidomide
KBio1_000474
KBio2_002087
KBio2_004655
KBio2_007223
 
KBio3_002642
KBioGR_000727
KBioSS_002087
L001344
LS-26936
Labetalol
Labetalol (INN)
Labetalol [INN:BAN]
Labetalolum
Labetalolum [INN-Latin]
Labetolol
Lopac0_000687
MolPort-003-898-140
NCGC00015595-06
NCGC00089800-02
NINDS_000474
NORMOZIDE
Prestwick0_000277
Prestwick1_000277
Prestwick2_000277
Prestwick3_000277
SBB067266
SPBio_000905
SPBio_002373
Sch-19927
Spectrum2_000863
Spectrum3_001581
Spectrum4_000184
Spectrum5_001010
Spectrum_001607
TL8002725
UNII-R5H8897N95
labetalol
17
Naltrexoneapproved, investigational, vet_approvedPhase 438816590-41-35360515
Synonyms:
16590-41-3
16676-29-2
17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one
3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one
BIDD:GT0405
BPBio1_000146
BRD-K88172511-310-03-8
BRN 3596648
BSPBio_000132
C07253
CCRIS 3506
CHEBI:121459
CHEBI:7465
CHEMBL142
CID5360515
Celupan
D05113
DB00704
Depade
EINECS 240-649-9
EN-1639A
HMS2089O11
HS-0002
HSDB 6750
LS-92094
MLS002153483
MolPort-004-920-221
 
MorViva
N-Cyclopropylmethyl-14-hydroxydihydromorphinone
N-Cyclopropylmethylnoroxymorphone
Naltrexon
Naltrexona
Naltrexona [INN-Spanish]
Naltrexone
Naltrexone (USAN/INN)
Naltrexone Hcl
Naltrexone [USAN:BAN:INN]
Naltrexone [USAN:INN:BAN]
Naltrexone [Usan:Ban:Inn]
Naltrexonum
Naltrexonum [INN-Latin]
PDSP2_000847
PTI-555
Prestwick0_000116
Prestwick1_000116
Prestwick2_000116
Prestwick3_000116
ReVia
SMP1_000206
SPBio_002071
UM-792
UNII-5S6W795CQM
Vivitrex
Vivitrol
Vivitrol (TN)
naltrexone
naltrexone (ReVia)
18Defibrotideapproved, investigationalPhase 41383712-60-1
19
Menadioneapproved, nutraceuticalPhase 423958-27-54055
Synonyms:
03AAE1E9-B215-45AF-976C-91E61894A467
1,4-Naphthalenedione, 2-methyl-, radical ion(1-)
2-Methyl-1,4-Naphthalenedione
2-Methyl-1,4-naftochinon
2-Methyl-1,4-naftochinon [Czech]
2-Methyl-1,4-naphthalendione
2-Methyl-1,4-naphthalenedione
2-Methyl-1,4-naphthochinon
2-Methyl-1,4-naphthochinon [German]
2-Methyl-1,4-naphthodione
2-Methyl-1,4-naphthoquinone
2-Methylnaphthoquinone
2-methyl-1,4-naphthoquinone, 5
2-methylnaphthalene-1,4-dione
3-Methyl-1,4-naphthoquinone
34524-96-4
47775_SUPELCO
58-27-5
72060-21-0
AC1L1HBA
AC1Q2HB3
AI3-14700
AKOS004910447
ARONIS24154
Aquakay
Aquinone
BB_NC-2319
BIDD:ER0556
BPBio1_000592
BSPBio_000538
Bio1_000471
Bio1_000960
Bio1_001449
C05377
C11H8O2
CAS-58-27-5
CCRIS 6672
CHEBI:28869
CHEMBL590
CID4055
CPD-3766
D02335
DB00170
DivK1c_000080
DivK1c_006287
EINECS 200-372-6
HMS1569K20
HMS1921P06
HMS2092F12
HMS500D22
HSDB 3354
Hemodal
I14-2821
IDI1_000080
InChI=1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H
Juva-K
K-Thrombyl
K-Vitan
KBio1_000080
KBio1_001231
KBio2_001708
KBio2_002527
KBio2_004276
KBio2_005095
KBio2_006844
KBio2_007663
KBio3_003005
KBioGR_000984
KBioGR_002527
KBioSS_001708
KBioSS_002535
Kaergona
Kanone
Kappaxan
Kappaxan (VAN)
Kappaxin
Kappaxin (TN)
Karcon
Kareon
Kativ-G
Kayklot
Kaykot
 
Kaynone
Kayquinone
Kipca
Kipca, oil soluble
Kipca-Oil Soluble
Klottone
Koaxin
Kolklot
LS-95653
LS-95654
M0373
M5625_SIGMA
M9429_SIGMA
MLS000069420
MLS001148443
MNQ
Memodol
Menadion
Menadione
Menadione (K3)
Menadione (USP)
Menadione [USAN:BAN]
Menadione semiquinone
Menadionum
Menaphthene
Menaphthon
Menaphthone
Menaphtone
Menaquinone
Menaquinone 0
Menaquinone O
Methyl-1,4-naphthalenedione
Methyl-1,4-naphthoquinone
Methylnaphthoquinone
Mitenon
Mitenone
MolPort-001-766-699
NCGC00016258-01
NCGC00094978-01
NCGC00094978-02
NCI60_003945
NCIMech_000105
NINDS_000080
NSC 4170
NSC4170
Panosine
Prestwick0_000459
Prestwick1_000459
Prestwick2_000459
Prestwick3_000459
Prestwick_313
Prokayvit
QTL1_000056
S1949_Selleck
SMR000059102
SMR000653532
SPBio_001267
SPBio_002477
SPECTRUM1502254
SpecPlus_000191
Spectrum2_001194
Spectrum4_000722
Spectrum5_001764
Spectrum_001228
Synkay
Thyloquinone
UNII-723JX6CXY5
Usaf ek-5185
VK3
Vicasol
Vitamin K 3
Vitamin K0
Vitamin K2
Vitamin K2(0)
Vitamin K3
Vitamin K3 : 2-Methyl-1,4-naphthoquinone
Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
Vitamin-?K3
WLN: L66 BV EVJ C1
ZINC00001677
cMAP_000077
menadione
nchembio.109-comp5
20
Phytonadioneapproved, NutraceuticalPhase 423984-80-04812, 5284607
Synonyms:
.alpha.-Phylloquinone
1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-)
10485-69-5
11104-38-4
15973-57-6
2', 3'-trans-Vitamin K1
2',3'-trans-Vitamin K1
2-(3,7,11,15-Tetramethylhexadec-2-enyl)-3-methylnaphthalene-1,4-dione
2-METHYL-3-PHYTYL-14-NAPHTHOQUINONE
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone
2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
2-Methyl-3-phythyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon [German]
2-Methyl-3-phytyl-1,4-naphthoquinone
2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione
2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
27696-10-2
3-Phytylmenadione
50926-17-5
84-80-0
AC1NQX34
AC1Q6B3J
AR-1E3503
Antihemorrhagic vitamin
Aqua mephyton
Aqua-Mephytin
Aquamephyton
C02059
C31H46O2
CID5280483
Combinal K1
D00148
DB01022
EINECS 201-564-2
EINECS 234-330-3
EINECS 279-833-9
Fitomenadiona
Fitomenadiona [INN-Spanish]
Fitomenadione
Fitomenadione [DCIT]
HSDB 3162
K-Ject
Kativ N
Kephton
 
Kinadion
Konakion
LS-94617
LT00452032
MLS001332659
MLS001332660
Mephyton
Mephyton (TN)
MolPort-001-785-978
Mono-Kay
Monodion
NCGC00159423-02
NSC 270681
NSC270681
P0642
Phyllochinon
Phyllochinon [German]
Phyllochinonum
Phylloquinone
Phylloquinone (8CI)
Phythyl-menadion
Phythyl-menadion (GERMAN)
Phytomenadione
Phytomenadione (INN)
Phytomenadionum
Phytomenadionum [INN-Latin]
Phytonadione
Phytonadione (JP15/USP)
Phytonadione [USAN:JAN]
Phytonadionum
Phytylmenadione
SMR000059144
ST075162
Synthex P
UNII-A034SE7857
VITAMIN K
VITAMIN K1
Vitamin K
Vitamin K 1
Vitamin K1
Vitamin K1 (TN)
Vitamin K1 (VAN)
Vitamin K1 (generic)
Vitamin K1(20)
alpha-Phylloquinone
phyllohydroquinone
phytonadione
trans-Phylloquinone
α-phylloquinone
21MicronutrientsPhase 4, Phase 36001
22Testosterone undecanoatePhase 4, Phase 3, Phase 2563
23Trace ElementsPhase 4, Phase 36001
24Antineoplastic Agents, HormonalPhase 4, Phase 3, Phase 25592
25VitaminsPhase 45282
26Hormone AntagonistsPhase 4, Phase 3, Phase 213180
27
Testosterone enanthatePhase 4, Phase 3, Phase 2563315-37-79416
Synonyms:
17-((1-Oxoheptyl)oxy)androst-4-en-3-one
17-Hydroxyandrost-4-en-3-one, 17-heptanoate
17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid
17beta-Enanthoxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-en-3-one enanthate
4-Androsten-17beta-ol-3-one 17-enanthate
4-Androsten-3-one 17beta-enanthate
Androgyn L.A.
Andropository
Androtardyl
Atlatest
DEA No. 4000
DePatestrye
Delatest
Delatestryl
Depo-Testro Med
Ditate
Durathate
Everone
 
Exten test
Malogen L.A.
Malogen L.A.200
Orquisteron-E
Primotestone
Reposo TMD
Testanthate
Testate
Testenate
Testinon
Testoenant
Testonenant
Testosterone 17-enanthate
Testosterone 17beta-heptanoate
Testosterone 17beta-heptanoic acid
Testosterone enantate
Testosterone heptoate
Testosterone heptoic acid
Testosterone heptylate
Testosterone oenanthate
Testostroval
28HormonesPhase 4, Phase 3, Phase 214415
29Testosterone 17 beta-cypionatePhase 4, Phase 3, Phase 2563
30AndrogensPhase 4, Phase 3, Phase 21321
31Natriuretic AgentsPhase 41697
32Gastrointestinal AgentsPhase 4, Phase 3, Phase 28402
33diureticsPhase 41418
34Sodium Potassium Chloride Symporter InhibitorsPhase 4181
35Protective AgentsPhase 4, Phase 3, Phase 2, Phase 17443
36Anabolic AgentsPhase 4, Phase 3, Phase 2513
37Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 213168
38Narcotic AntagonistsPhase 4, Phase 2, Phase 1935
39
protease inhibitorsPhase 4, Phase 2, Phase 35471
Synonyms:
 
protease inhibitors
40Serine Proteinase InhibitorsPhase 4, Phase 3878
41Adrenergic AgentsPhase 4, Phase 15352
42Antihypertensive AgentsPhase 4, Phase 3, Phase 14207
43Vasodilator AgentsPhase 4, Phase 2, Phase 13543
44Platelet Aggregation InhibitorsPhase 4, Phase 32516
45Adrenergic beta-AntagonistsPhase 4, Phase 11193
46Adrenergic AntagonistsPhase 4, Phase 11573
47Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 210729
48glucocorticoidsPhase 4, Phase 3, Phase 25103
49
Proton pump inhibitorsPhase 41123
Synonyms:
 
PPIs
50NarcoticsPhase 4, Phase 2, Phase 13646

Interventional clinical trials:

(show top 50)    (show all 272)
idNameStatusNCT IDPhase
1Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male VolunteersUnknown statusNCT01156220Phase 4
2Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal MenUnknown statusNCT01699178Phase 4
3Balloon Angioplasty Versus Xpert Stent in CLI Patients XXS StudyUnknown statusNCT00546845Phase 4
4Radiofrequency Ablation for Malignant Biliary ObstructionCompletedNCT01758341Phase 4
5Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342)CompletedNCT00325676Phase 4
6Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected PatientsCompletedNCT00574925Phase 4
7Donor Dopamine and Initial Graft FunctionCompletedNCT00115115Phase 4
8Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial FibrillationCompletedNCT00161538Phase 4
9Pain Reduction After CholecystectomyCompletedNCT01199406Phase 4
10Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Density in Hormone Sensitive Prostate Cancer Patients With Bone MetastasisCompletedNCT00035997Phase 4
11Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)CompletedNCT02100228Phase 4
12Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism?RecruitingNCT02806440Phase 4
13Biomarker Guided Treatment in Gynaecological CancerRecruitingNCT02543710Phase 4
14European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic StrokeRecruitingNCT02678169Phase 4
15Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis ParticipantsRecruitingNCT02573012Phase 4
16Chronic Hypertension and Pregnancy (CHAP) ProjectRecruitingNCT02299414Phase 4
17Pinloc Versus Hansson Pins in the Treatment of Femoral Neck Fractures.RecruitingNCT02776631Phase 4
18Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After Pulmonary Vein Isolation for Atrial FibrillationRecruitingNCT02067182Phase 4
19Long-term Safety, Curvature Deformity Characterization, and Immunogenicity Over Time in Subjects Previously Treated With AA4500 for Peyronies DiseaseActive, not recruitingNCT02298829Phase 4
20Defibrotide in the Human Endotoxemia Model --‐ an Exploratory Trial Investigating the Effects and the Mechanisms of DefibrotideNot yet recruitingNCT02876601Phase 4
21Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing CholangitisUnknown statusNCT01398917Phase 3
22Multi Centre Trial of DSMM for Newly Diagnosed Multiple Myeloma up to 60 YearsUnknown statusNCT00546988Phase 3
23Imatinib Mesylate With or Without Interferon Alfa or Cytarabine Compared With Interferon Alfa Followed by Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous LeukemiaUnknown statusNCT00055874Phase 3
24F18PET/CT Versus TC-MDP Scanning to Detect Bone MetsUnknown statusNCT00882609Phase 3
25Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope SurgeryCompletedNCT01219881Phase 3
26Bladder Scan of Residual Urine With New CatheterCompletedNCT01048541Phase 2, Phase 3
27Trigger-point Blockade in Persistent Pain After Open Groin Hernia RepairCompletedNCT02065219Phase 3
28Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.CompletedNCT01218607Phase 3
29Comparing Two Forms of Head Immobilization for Stereotactic RadiotherapyCompletedNCT00328510Phase 3
30Efficacy and Safety Trial of Transcranial Laser Therapy Within 24 Hours From Stroke Onset (NEST-3)CompletedNCT01120301Phase 3
31Gemcitabine With or Without Capecitabine in Treating Patients With Advanced Pancreatic CancerCompletedNCT00030732Phase 3
32Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment (BY2001/M1-007)CompletedNCT00074906Phase 3
33Study About Efficacy and Safety to Treat Multi-System-AtrophyCompletedNCT00146809Phase 3
34Efficacy, Safety, Tolerability of Neramexane in Patients With Subjective TinnitusCompletedNCT00955799Phase 3
35Efficacy, Safety and Tolerability of Neramexane in Patients With Subjective TinnitusCompletedNCT00739635Phase 3
36Monoclonal Antibody Therapy (Rencarex®) in Treating Patients Who Have Undergone Surgery for Non-metastatic Kidney CancerCompletedNCT00087022Phase 3
37Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal MenCompletedNCT01403116Phase 3
38Study of AA4500 in the Treatment of Peyronie's DiseaseCompletedNCT01221623Phase 3
39Study of Atrasentan in Men With Non-Metastatic, Hormone-Refractory Prostate CancerCompletedNCT00036556Phase 3
40Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)CompletedNCT00106691Phase 3
41Study to Investigate Efficacy and Safety of a New Oral ContraceptiveCompletedNCT00185289Phase 3
42Efficacy and Long-Term Safety of Vildagliptin as Add-on Therapy to Metformin in Patients With Type 2 DiabetesCompletedNCT00860288Phase 2, Phase 3
43Bryophyllum Pinnatum Versus Solifenacin Versus Placebo for Overactive BladderRecruitingNCT02129816Phase 2, Phase 3
44Tasigna and Interferon Alpha Evaluation Initiated by the German Chronic Myeloid Leukemia Study Group - the TIGER StudyRecruitingNCT01657604Phase 3
45Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and EtoposideRecruitingNCT00632853Phase 3
46BAMI. The Effect of Intracoronary Reinfusion of Bone Marrow-derived Mononuclear Cells(BM-MNC) on All Cause Mortality in Acute Myocardial InfarctionRecruitingNCT01569178Phase 3
47Cediranib Maleate and Olaparib or Standard Chemotherapy in Treating Patients With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal CancerRecruitingNCT02502266Phase 2, Phase 3
48Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate CancerRecruitingNCT01368588Phase 3
49Double Blind Placebo Controlled Controlled Study of Adjuvant MEDI4736 In Completely Resected NSCLCRecruitingNCT02273375Phase 3
50Evaluation of MGN1703 Maintenance Treatment in Patients With mCRC With Tumor Reduction During Induction TreatmentRecruitingNCT02077868Phase 3

Search NIH Clinical Center for Werner Syndrome


Cochrane evidence based reviews: werner syndrome

Genetic Tests for Werner Syndrome

About this section

Genetic tests related to Werner Syndrome:

id Genetic test Affiliating Genes
1 Werner Syndrome27 24 WRN

Anatomical Context for Werner Syndrome

About this section

MalaCards organs/tissues related to Werner Syndrome:

36
Skin, Heart, Lung, Thyroid, Breast, Eye, Small intestine

Publications for Werner Syndrome

About this section

Articles related to Werner Syndrome:

(show top 50)    (show all 467)
idTitleAuthorsYear
1
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype. (28276523)
2017
2
Nailfold scleroderma-like capillary abnormalities in Werner syndrome (adult progeria). (28466674)
2017
3
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA. (28069813)
2017
4
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase I' Elongation. (27849570)
2017
5
Accelerated epigenetic aging in Werner syndrome. (28377537)
2017
6
Case of Werner syndrome complicated by adrenal insufficiency due to hypothalamic dysfunction. (28240455)
2017
7
Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome. (28394436)
2017
8
Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model. (28119126)
2017
9
Femoral osteoporosis is more common than lumbar osteoporosis in patients with Werner syndrome. (28508498)
2017
10
A novel splice-site mutation of WRN (c.IVS28+2T>C) identified in a consanguineous family with Werner Syndrome. (28440507)
2017
11
Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase. (27427477)
2016
12
Improved Glycemic Control and Vascular Function and Reduction of Abdominal Fat Accumulation with Liraglutide in a Case of Werner Syndrome with Diabetes Mellitus. (27000366)
2016
13
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription. (26984941)
2016
14
WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers. (28012115)
2016
15
The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks. (26691982)
2016
16
Adult Progeria: Werner Syndrome. (27734655)
2016
17
Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation. (27539898)
2016
18
Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts. (27136566)
2016
19
Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions. (26993153)
2016
20
Radiographic presentation of musculoskeletal involvement in Werner syndrome (adult progeria). (27931782)
2016
21
Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. (27271327)
2016
22
Werner syndrome through the lens of tissue and tumour genomics. (27559010)
2016
23
Case of sarcomatoid carcinoma occurring in a patient with Werner syndrome. (27074772)
2016
24
Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome. (27195193)
2016
25
The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. (26611938)
2016
26
Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient. (26788395)
2015
27
Werner Syndrome with Heart Block. (26071823)
2015
28
Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract. (26509079)
2015
29
Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells. (25730140)
2015
30
Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells. (26046488)
2015
31
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. (25931448)
2015
32
Astaxanthin Improves Nonalcoholic Fatty Liver Disease in Werner Syndrome with Diabetes Mellitus. (26096415)
2015
33
Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase. (26521679)
2015
34
A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies. (25830902)
2015
35
A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population. (25637295)
2015
36
WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. (25503078)
2015
37
Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. (25688260)
2015
38
Multiplex cytokine analysis of Werner syndrome. (26668779)
2015
39
Methylation of Werner syndrome protein is associated with the occurrence and development of invasive meningioma via the regulation of Myc and p53 expression. (26622343)
2015
40
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome. (26172944)
2015
41
Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer. (26690424)
2015
42
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice. (26447695)
2015
43
Search and Insights into Novel Genetic Alterations Leading to Classical and Atypical Werner Syndrome. (24401204)
2014
44
Telomerase protects werner syndrome lineage-specific stem cells from premature aging. (24749076)
2014
45
Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas. (24620826)
2014
46
A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (Review). (24356923)
2014
47
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. (25294835)
2014
48
Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities. (24965941)
2014
49
First Japanese case of atypical progeroid syndrome/atypical Werner syndrome with heterozygous LMNA mutation. (25327215)
2014
50
Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells. (25257404)
2014

Variations for Werner Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Werner Syndrome:

70
id Symbol AA change Variation ID SNP ID
1WRNp.Lys125AsnVAR_026588rs387906337
2WRNp.Lys135GluVAR_026589rs267607008

Clinvar genetic disease variations for Werner Syndrome:

5 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1WRNNM_ 000553.4(WRN): c.561A> G (p.Lys187=)SNVPathogenicrs775802030GRCh37Chr 8, 30924605: 30924605
2WRNNM_ 000553.4(WRN): c.487_ 488delGA (p.Asp163Cysfs)deletionLikely pathogenicrs797045118GRCh37Chr 8, 30922562: 30922563
3WRNNM_ 000553.4(WRN): c.15delA (p.Lys5Asnfs)deletionPathogenicrs878854133GRCh37Chr 8, 30915978: 30915978
4WRNNM_ 000553.4(WRN): c.2546_ 2547dupAT (p.Gln850Ilefs)duplicationPathogenicrs878854136GRCh38Chr 8, 31120340: 31120341
5WRNNM_ 000553.4(WRN): c.2959C> T (p.Arg987Ter)SNVLikely pathogenicrs747319628GRCh38Chr 8, 31132498: 31132498
6WRNNM_ 000553.4(WRN): c.2089-3024A> GSNVPathogenicrs281865157GRCh37Chr 8, 30966107: 30966107
7WRNNM_ 000553.4(WRN): c.2179dupT (p.Cys727Leufs)duplicationPathogenicrs281865158GRCh37Chr 8, 30969221: 30969221
8WRNNM_ 000553.4(WRN): c.3460-2A> CSNVPathogenicrs281865159GRCh37Chr 8, 31004878: 31004878
9WRNNM_ 000553.4(WRN): c.3590delA (p.Asn1197Thrfs)deletionPathogenicrs281865160GRCh37Chr 8, 31007874: 31007874
10WRNNM_ 000553.4(WRN): c.502_ 503delAA (p.Lys168Alafs)deletionPathogenicrs1060500056GRCh38Chr 8, 31065061: 31065062
11WRNNM_ 000553.4(WRN): c.673C> T (p.Arg225Ter)SNVPathogenicrs370324188GRCh38Chr 8, 31068276: 31068276
12WRNNM_ 000553.4(WRN): c.1898+2T> GSNVLikely pathogenicrs772319506GRCh38Chr 8, 31091900: 31091900
13WRNNM_ 000553.4(WRN): c.2665C> T (p.Arg889Ter)SNVPathogenicrs774765029GRCh38Chr 8, 31124556: 31124556
14WRNNC_ 000008.11: g.(?_ 31150341)_ (31157530_ ?)deldeletionPathogenicGRCh38Chr 8, 31150341: 31157530
15WRNNM_ 000553.4(WRN): c.3913C> T (p.Arg1305Ter)SNVPathogenicrs121908446GRCh37Chr 8, 31014977: 31014977
16WRNNM_ 000553.4(WRN): c.3493C> T (p.Gln1165Ter)SNVPathogenicrs121908447GRCh37Chr 8, 31004913: 31004913
17WRNNM_ 000553.4(WRN): c.3690_ 3693delAGAC (p.Asp1231Serfs)deletionPathogenicrs606231162GRCh38Chr 8, 31154626: 31154629
18WRNNM_ 000553.4(WRN): c.3139-1G> CSNVPathogenicrs113993961GRCh37Chr 8, 30999196: 30999196
19WRNNM_ 000553.4(WRN): c.3915dupA (p.Ala1306Serfs)duplicationPathogenicrs587776621GRCh37Chr 8, 31014979: 31014979
20WRNNM_ 000553.4(WRN): c.1105C> T (p.Arg369Ter)SNVPathogenicrs17847577GRCh37Chr 8, 30938648: 30938648
21WRNNM_ 000553.4(WRN): c.3686A> T (p.Gln1229Leu)SNVPathogenicrs369158322GRCh38Chr 8, 31150454: 31150454
22WRNRECQL2, 1-BP DEL, NT1396deletionPathogenic
23WRNNM_ 000553.4(WRN): c.1730A> T (p.Lys577Met)SNVPathogenicrs121908448GRCh37Chr 8, 30948359: 30948359

Expression for genes affiliated with Werner Syndrome

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Search GEO for disease gene expression data for Werner Syndrome.

Pathways for genes affiliated with Werner Syndrome

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Pathways related to Werner Syndrome according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.6NBN, XRCC5
2
Show member pathways
9.4BLM, HELLS, NBN
3
Show member pathways
9.4EXO1, FEN1, RPA1
4
Show member pathways
9.1BLM, LMNA, NBN, RPA1
59.1BLM, NBN, WRN, XRCC5
69.1FEN1, NBN, WRN, XRCC5
7
Show member pathways
8.9BLM, PARP1, RPA1, WRN
8
Show member pathways
8.7BLM, EXO1, NBN, RPA1, WRN
9
Show member pathways
8.7BLM, EXO1, NBN, RPA1, WRN
10
Show member pathways
8.7BLM, EXO1, NBN, RPA1, WRN
11
Show member pathways
8.7BLM, EXO1, NBN, RPA1, WRN
12
Show member pathways
8.5FEN1, PARP1, POLB, RPA1, WRN
13
Show member pathways
8.2BLM, EXO1, FEN1, LMNA, NBN, RPA1
14
Show member pathways
8.1FEN1, NBN, PARP1, POLB, XRCC5
156.7BLM, FEN1, LMNA, NBN, RECQL, RECQL4
16
Show member pathways
6.3BLM, EXO1, FEN1, NBN, PARP1, POLB

GO Terms for genes affiliated with Werner Syndrome

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Cellular components related to Werner Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:001660510.1BLM, NBN, RPA1
2chromosome, telomeric regionGO:00007819.9BLM, NBN, RECQL4, WRN
3replication forkGO:00056579.5BLM, NBN, WRN
4chromosomeGO:00056949.3NBN, RECQL, RECQL4, RECQL5, WRN, XRCC5
5nucleolusGO:00057308.8BLM, FEN1, NBN, PARP1, WRN, XRCC5
6nuclear chromosome, telomeric regionGO:00007848.5FEN1, NBN, PARP1, RPA1, WRNIP1, XRCC5
7protein complexGO:00432348.4FEN1, PARP1, POLB, VCP, XRCC5
8nucleoplasmGO:00056546.3BLM, EXO1, FEN1, LMNA, NBN, PARP1
9nucleusGO:00056345.0BLM, EXO1, FEN1, HELLS, LMNA, NBN

Biological processes related to Werner Syndrome according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cellular metabolic processGO:004423710.8BLM, WRN
2cellular response to camptothecinGO:007275710.7BLM, RECQL5
3G-quadruplex DNA unwindingGO:004480610.7BLM, WRN
4cellular response to gamma radiationGO:007148010.6WRN, XRCC5
5replication fork processingGO:003129710.6BLM, WRN
6DNA-dependent DNA replicationGO:000626110.5POLB, RPA1
7DNA double-strand break processingGO:000072910.4BLM, NBN
8nucleotide-excision repair, DNA gap fillingGO:000629710.4POLB, RPA1
9mitotic G2 DNA damage checkpointGO:000709510.4BLM, NBN
10DNA strand renaturationGO:000073310.3BLM, RECQL, RECQL4
11error-free translesion synthesisGO:007098710.2RPA1, VCP
12somatic hypermutation of immunoglobulin genesGO:001644610.2EXO1, POLB
13isotype switchingGO:004519010.2EXO1, NBN
14nucleic acid phosphodiester bond hydrolysisGO:009030510.1EXO1, FEN1, WRN
15regulation of DNA-dependent DNA replication initiationGO:003017410.0NBN, WRNIP1
16nucleotide-excision repair, DNA incision, 3-to lesionGO:000629510.0PARP1, RPA1
17nucleotide-excision repair, preincision complex assemblyGO:00062949.9PARP1, RPA1
18nucleotide-excision repair, preincision complex stabilizationGO:00062939.9PARP1, RPA1
19negative regulation of telomere maintenance via telomere lengtheningGO:19043579.8NBN, PARP1
20base-excision repairGO:00062849.6FEN1, POLB, RECQL4, RPA1, WRN
21telomeric D-loop disassemblyGO:00618209.6BLM, RECQL4, WRN
22strand displacementGO:00007329.5BLM, EXO1, NBN, WRN
23t-circle formationGO:00906569.5BLM, EXO1, NBN, WRN
24regulation of signal transduction by p53 class mediatorGO:19017969.3BLM, EXO1, NBN, RPA1, WRN
25DNA synthesis involved in DNA repairGO:00007319.2BLM, EXO1, NBN, WRN, WRNIP1
26DNA duplex unwindingGO:00325088.9BLM, NBN, RECQL, RECQL4, RECQL5, WRN
27DNA recombinationGO:00063108.7BLM, EXO1, RECQL, RECQL4, RECQL5, RPA1
28double-strand break repairGO:00063028.3FEN1, NBN, PARP1, VCP, WRN, XRCC5
29telomere maintenanceGO:00007238.0NBN, PARP1, RECQL4, RPA1, WRN, XRCC5
30double-strand break repair via homologous recombinationGO:00007247.8BLM, FEN1, NBN, PARP1, RECQL, RECQL4
31DNA replicationGO:00062607.6BLM, EXO1, FEN1, NBN, POLB, RECQL4
32cellular response to DNA damage stimulusGO:00069746.2BLM, EXO1, FEN1, NBN, PARP1, POLB
33DNA repairGO:00062815.5BLM, EXO1, FEN1, NBN, PARP1, POLB

Molecular functions related to Werner Syndrome according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
18-hydroxy-2-deoxyguanosine DNA bindingGO:190577310.9BLM, WRN
2forked DNA-dependent helicase activityGO:006174910.9BLM, WRN
3four-way junction DNA bindingGO:000040010.9BLM, WRN
4G-quadruplex DNA bindingGO:005188010.9BLM, WRN
55-3 exonuclease activityGO:000840910.6EXO1, FEN1
6flap endonuclease activityGO:004825610.6EXO1, FEN1
7bubble DNA bindingGO:000040510.5BLM, RECQL4, WRN
8annealing helicase activityGO:003631010.4BLM, RECQL, RECQL4
9oxidized purine DNA bindingGO:003235710.4BLM, RECQL4, WRN
10DNA helicase activityGO:000367810.4BLM, RECQL, RECQL5, WRN
11exonuclease activityGO:000452710.3EXO1, FEN1, WRN
12nuclease activityGO:000451810.3EXO1, FEN1, WRN
13catalytic activityGO:000382410.1BLM, EXO1, FEN1, WRN
14nucleic acid bindingGO:000367610.0BLM, RECQL, RECQL5, RPA1, WRN
15Y-form DNA bindingGO:000040310.0BLM, WRN
16ATP-dependent 3-5 DNA helicase activityGO:004314010.0BLM, RECQL, RECQL4, RECQL5, WRN
17ATP-dependent helicase activityGO:000802610.0BLM, RECQL, RECQL4, RECQL5, WRN
18four-way junction helicase activityGO:000937810.0BLM, RECQL, RECQL4, RECQL5, WRN
19RNA-DNA hybrid ribonuclease activityGO:00045239.9EXO1, FEN1
20ATP-dependent DNA helicase activityGO:00040039.7BLM, NBN, RECQL, WRN, XRCC5
21ATPase activityGO:00168879.7BLM, VCP, WRN, WRNIP1
22telomeric D-loop bindingGO:00618219.7BLM, RECQL4, WRN
23damaged DNA bindingGO:00036849.5FEN1, NBN, POLB, RPA1, XRCC5
24helicase activityGO:00043869.3BLM, HELLS, RECQL, RECQL4, RECQL5, WRN
25ATP bindingGO:00055248.1BLM, HELLS, RECQL, RECQL4, RECQL5, VCP
26hydrolase activityGO:00167877.8BLM, EXO1, FEN1, HELLS, RECQL, RECQL5
27DNA bindingGO:00036777.6BLM, EXO1, FEN1, PARP1, RECQL, RECQL5
28protein bindingGO:00055154.9BLM, EXO1, FEN1, HELLS, LMNA, NBN

Sources for Werner Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet