WS
MCID: WRN001
MIFTS: 70

Werner Syndrome (WS) malady

Genetic diseases, Rare diseases, Eye diseases, Skin diseases, Fetal diseases, Cancer diseases categories
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Summaries for Werner Syndrome

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43NIH Rare Diseases, 21Genetics Home Reference, 65Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Werner's syndrome is a disease chiefly characterized by premature aging and cancer predisposition. development is typically normal until the end of the first decade; the first sign is the lack of a growth spurt during puberty. early signs (usually in the 20s) include loss and graying of hair, hoarseness, and scleroderma-like skin changes, followed by cataracts, type 2 diabetes mellitus, hypogonadism, skin ulcers, and osteoporosis in the 30s. myocardial infarction (heart attack) and cancer are the most common causes of death, which typically occurs in the late 40s. it is caused by mutations in the wrn gene and is inherited in an autosomal recessive manner. management focuses on treatment of signs and symptoms and prevention of secondary complications. last updated: 4/29/2011

MalaCards: Werner Syndrome, also known as werner's syndrome, is related to progeria and rapadilino syndrome, and has symptoms including beaked nose, white forelock/piebaldism and oropharyngeal neoplasm/tumor/carcinoma/cancer. An important gene associated with Werner Syndrome is WRN (Werner syndrome, RecQ helicase-like), and among its related pathways are Regulation of Telomerase and Fanconi anemia pathway. The compounds 8-oxoguanine and polynucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and thyroid, and related mouse phenotypes are vision/eye and integument.

Genetics Home Reference:21 Werner syndrome is characterized by the dramatic, rapid appearance of features associated with normal aging. Individuals with this disorder typically grow and develop normally until they reach puberty. Affected teenagers usually do not have a growth spurt, resulting in short stature. The characteristic aged appearance of individuals with Werner syndrome typically begins to develop when they are in their twenties and includes graying and loss of hair; a hoarse voice; and thin, hardened skin. They may also have a facial appearance described as "bird-like." Many people with Werner syndrome have thin arms and legs and a thick trunk due to abnormal fat deposition.

Wikipedia:65 Werner syndrome (WS), also known as \"adult progeria\", is a rare, autosomal recessiveprogeroid syndrome... more...

Description from OMIM:47 277700

GeneReviews summary for werner

Aliases & Classifications for Werner Syndrome

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8Disease Ontology, 9diseasecard, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
werner syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

werner syndrome 8 9 19 43 21 47 10 45 49 62
werner's syndrome 8 43 20 22 21
adult progeria 8 21 49
ws 8 21 49
adult premature ageing syndrome 8
adult premature aging syndrome 21
werners syndrome 21
wrn 43


External Ids:

Disease Ontology8 DOID:5688
NCIt40 C3447
OMIM47 277700
MeSH35 D014898
MESH via Orphanet36 D014898
ICD10 via Orphanet26 E34.8
SNOMED-CT via Orphanet59 51626007
UMLS via Orphanet63 C0043119

Related Diseases for Werner Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Werner Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1progeria30.9LMNA, WRN
2rapadilino syndrome30.5RECQL4, WRN
3ataxia telangiectasia30.4BLM, WRN, RPA1
4osteosarcoma30.3WRN, RPA1, RECQL4
5rothmund-thomson syndrome30.3RECQL4, BLM, WRN
6bloom syndrome30.2WRN, FEN1, RECQL4, RAD54L, BLM
7xeroderma pigmentosum29.9RAD54L, FEN1, RPA1
8leukemia29.9POLB, GYPA, RPA1, RECQL4
9breast cancer29.8WRN, RPA1, LMNA, POLB, FEN1
10williams syndrome10.6
11atypical werner syndrome10.5
12waardenburg syndrome type i10.4
13insulin resistance10.4
14waardenburg syndrome type 310.3
15meningioma10.3
16waardenburg syndrome type 2a10.3
17waardenburg syndrome type iva10.3
18colorectal cancer10.3
19ataxia10.2
20spondylosis10.2
21coronary artery disease10.2
22artery disease10.2
23hyperglycemia10.2
24sarcoma10.2
25thyroiditis10.2
26bile reflux10.1
27waardenburg syndrome type 210.1
28waardenburg syndrome type ivb10.1
29waardenburg syndrome type ivc10.1
30waardenburg syndrome type iid10.1
31waardenburg syndrome, type 2e, with or without neurologic involvement10.1
32tangier disease10.0
33neuronitis10.0
34petroclival meningioma10.0
35fragile x syndrome10.0
36down syndrome10.0
37atherosclerosis10.0
38bladder carcinoma10.0
39cataract10.0
40chondrosarcoma10.0
41diabetes mellitus10.0
42glaucoma10.0
43lipodystrophy10.0
44lung cancer10.0
45melanoma10.0
46obesity10.0
47osteoporosis10.0
48osteosclerosis10.0
49pancreatic cancer10.0
50pancreatitis10.0

Graphical network of the top 20 diseases related to Werner Syndrome:



Diseases related to werner syndrome

Symptoms for Werner Syndrome

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47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

277700

Clinical features from OMIM:

277700

Symptoms:

49 (show all 56)
  • beaked nose
  • white forelock/piebaldism
  • oropharyngeal neoplasm/tumor/carcinoma/cancer
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)
  • small hand/acromicria
  • meningioma
  • digestive neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • breast neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • thyroid neoplasm/tumor/carcinoma/cancer
  • global upper and lower limbs anomalies
  • short stature/dwarfism/nanism
  • oral cavity/tongue neoplasm/tumor/carcinoma/cancer
  • abnormal fall of hair
  • pili torti
  • abnormal fat distribution/lipodystrophy
  • arterial pulse abolition
  • testis anomalies
  • pes talus
  • arterial atheroma/precocious atherosclerosis/arteriosclerosis
  • pulmonary artery stenosis/absence/hypoplasia of the pulmonary branches
  • sterility/hypofertility
  • chronic skin infection/ulcerations/ulcers/cancrum
  • osteosclerosis/osteopetrosis/bone condensation
  • lipoatrophy
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • abnormal cry/voice/phonation disorder/nasal speech
  • laryngomalacia
  • late puberty/hypogonadism/hypogenitalism
  • retinitis pigmentosa/retinal pigmentary changes
  • restricted joint mobility/joint stiffness/ankylosis
  • cataract/lens opacification
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • diabetes mellitus
  • chronic arterial hypertension
  • autosomal dominant inheritance
  • telangiectasiae of the skin
  • anomalies of chest/thorax/trunk
  • sarcoma
  • skin hypoplasia/aplasia/atrophy
  • premature ageing
  • narrow face
  • neoplasms/tumors
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • cerebral vascular anomalies
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • small/atrophic/hypoplastic testes/monorchism/microorchidism/anorchia
  • precocious menopause/secondary amenorrhea
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • periarticular tissue anomaly/extraarticular calcifications
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • tight skin/lack of elasticity
  • autosomal recessive inheritance

Drugs & Therapeutics for Werner Syndrome

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Werner Syndrome

Search NIH Clinical Center for Werner Syndrome

Genetic Tests for Werner Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Werner Syndrome:

id Genetic test Affiliating Genes
1 Werner Syndrome20 22 WRN

Anatomical Context for Werner Syndrome

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33MalaCards
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MalaCards organs/tissues related to Werner Syndrome:

33
Skin, Heart, Thyroid, Breast, Lung, Kidney, Testis, Tongue, Bone, Ovary, Eye, Testes, Liver

Animal Models for Werner Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Werner Syndrome:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.1TREX1, RECQL4, LMNA, WRN
2MP:00107718.4BLM, WRN, POLB, LMNA, RECQL4, TREX1
3MP:00053708.4FEN1, POLB, LMNA, TREX1
4MP:00053818.4WRN, FEN1, LMNA, RECQL4, TREX1
5MP:00020068.2BLM, WRN, FEN1, RECQL4, RPA1
6MP:00053888.2FEN1, POLB, LMNA, TREX1
7MP:00053767.6WRN, FEN1, POLB, LMNA, RAD54L, TREX1
8MP:00053787.6BLM, WRN, FEN1, POLB, LMNA, RECQL4
9MP:00053976.8BLM, FEN1, POLB, LMNA, RECQL4, RPA1
10MP:00053876.6TREX1, BLM, WRN, FEN1, POLB, LMNA
11MP:00053846.5BLM, WRN, FEN1, POLB, LMNA, RECQL4
12MP:00107686.5BLM, WRN, FEN1, POLB, LMNA, RECQL4

Publications for Werner Syndrome

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52PubMed
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Articles related to Werner Syndrome:

(show top 50)    (show all 396)
idTitleAuthorsYear
1
DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations. (23847654)
2013
2
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. (23867477)
2013
3
Diabetes mellitus and cancer in Werner syndrome. (23386316)
2013
4
Leg ulcer in Werner syndrome (adult progeria): a case report. (23552003)
2013
5
The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome. (23360642)
2013
6
The Werner syndrome protein: linking the replication checkpoint response to genome stability. (21389352)
2011
7
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. (20516064)
2010
8
Estrogen prevents senescence through induction of WRN, Werner syndrome protein. (20395656)
2010
9
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. (20237955)
2010
10
Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. (20536832)
2010
11
Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells. (21426187)
2010
12
Werner syndrome as a possible cause of non-alcoholic steatohepatitis. (19720629)
2009
13
Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein. (18588880)
2008
14
Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome. (20103906)
2008
15
The atypical of Werner syndrome: effect of laminopathy]. (18959190)
2008
16
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. (17659871)
2007
17
Role for the Werner syndrome protein in the promotion of tumor cell growth. (17624410)
2007
18
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. (17715146)
2007
19
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains. (16503984)
2006
20
Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. (16720342)
2006
21
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. (16714450)
2006
22
In vivo prooxidant state in Werner syndrome (WS): results from three WS patients and two WS heterozygotes. (16036329)
2005
23
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. (15733840)
2005
24
Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome. (15897889)
2005
25
Werner syndrome protein--unwinding function to explain disease. (15056797)
2004
26
A possible case of Werner syndrome presenting with multiple cancers. (15513515)
2004
27
Werner syndrome protein, the MRE11 complex and ATR: menage-A -trois in guarding genome stability during DNA replication? (14988932)
2004
28
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. (12944467)
2003
29
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent. (12881525)
2003
30
Werner syndrome protein contains three structure-specific DNA binding domains. (14534320)
2003
31
Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases]. (11979727)
2002
32
Homologous recombination resolution defect in werner syndrome. (12242278)
2002
33
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. (11598021)
2001
34
Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein. (11238454)
2001
35
Severe heart valve calcification in a young patient with Werner syndrome. (10739908)
2000
36
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases. (10782115)
2000
37
WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. (10811112)
2000
38
Functional interaction between Ku and the werner syndrome protein in DNA end processing. (10880505)
2000
39
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts. (10973920)
2000
40
Calcaneal osteosarcoma associated with Werner syndrome. A case report with mutation analysis. (11005522)
2000
41
The Werner syndrome protein is a DNA helicase. (9288107)
1997
42
Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome. (7545922)
1994
43
Werner syndrome and biological ageing: a molecular genetic hypothesis. (8357345)
1993
44
Werner Syndrome (20301687)
1993
45
Effect of insulin on the proline transport activity in cultured fibroblasts from patients with Werner syndrome. (1419149)
1992
46
Mutator phenotype of Werner syndrome is characterized by extensive deletions. (2762303)
1989
47
Histone H1 in G1 arrested, senescent, and Werner syndrome fibroblasts. (3909768)
1985
48
A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome. (3909767)
1985
49
Cytogenetic studies using various clastogens in two patients with Werner syndrome and control individuals. (4018799)
1985
50
Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts. (7327553)
1981

Variations for Werner Syndrome

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Werner Syndrome:

64
id Symbol AA change Variation ID SNP ID
1WRNp.Lys125AsnVAR_026588
2WRNp.Lys135GluVAR_026589

Clinvar genetic disease variations for Werner Syndrome:

1 (show all 14)
id Gene Name Type Significance SNP ID Assembly Location
1WRNNM_000553.4(WRN): c.2089-3024A> Gsingle nucleotide variantPathogenicrs281865157GRCh37Chr 8, 30966107: 30966107
2WRNNM_000553.4(WRN): c.2179dupT (p.Cys727Leufs)duplicationPathogenicrs281865158GRCh37Chr 8, 30969221: 30969222
3WRNNM_000553.4(WRN): c.3460-2A> Csingle nucleotide variantPathogenicrs281865159GRCh37Chr 8, 31004878: 31004878
4WRNNM_000553.4(WRN): c.3590delA (p.Asn1197Thrfs)deletionPathogenicrs281865160GRCh37Chr 8, 31007874: 31007874
5WRNNM_000553.4(WRN): c.3913C> T (p.Arg1305Ter)single nucleotide variantPathogenicrs121908446GRCh37Chr 8, 31014977: 31014977
6WRNNM_000553.4(WRN): c.3493C> T (p.Gln1165Ter)single nucleotide variantPathogenicrs121908447GRCh37Chr 8, 31004913: 31004913
7WRNRECQL2, 4-BP DEL, FS1393TERdeletionPathogenic
8WRNNM_000553.4(WRN): c.3139-1G> Csingle nucleotide variantPathogenicrs113993961GRCh37Chr 8, 30999196: 30999196
9WRNNM_000553.4(WRN): c.3915dupA (p.Ala1306Serfs)duplicationPathogenicGRCh37Chr 8, 31014979: 31014979
10WRNNM_000553.4(WRN): c.1105C> T (p.Arg369Ter)single nucleotide variantPathogenicrs17847577GRCh37Chr 8, 30938648: 30938648
11WRNRECQL2, IVS31DS, A-T, +2, FS1158TERsingle nucleotide variantPathogenic
12WRNRECQL2, 1-BP DEL, NT1396deletionPathogenic
13WRNNM_000553.4(WRN): c.1730A> T (p.Lys577Met)single nucleotide variantPathogenicrs121908448GRCh37Chr 8, 30948359: 30948359
14WRNNM_000553.4(WRN): c.375A> T (p.Lys125Asn)single nucleotide variantPathogenicrs387906337GRCh37Chr 8, 30922450: 30922450

Expression for genes affiliated with Werner Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Werner Syndrome

Search GEO for disease gene expression data for Werner Syndrome.

Pathways for genes affiliated with Werner Syndrome

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 60Thomson Reuters, 55Reactome, 53QIAGEN, 5Cell Signaling Technology
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Pathways related to Werner Syndrome according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8WRN, BLM
29.5RPA1, BLM
39.4BLM, RAD54L
4
Show member pathways
Non-homologous end joining38
DNA damage NHEJ mechanisms of DSBs repair60
9.4FEN1, WRN
5
Show member pathways
9.2RPA1, LMNA, BLM
6
Show member pathways
9.2POLB, FEN1
7
Show member pathways
9.1FEN1, RPA1
8
Show member pathways
Homologous recombination38
8.9RAD54L, RPA1, BLM
9
Show member pathways
8.8WRN, FEN1, RPA1
10
Show member pathways
8.8FEN1, POLB, TREX1
11
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.8RPA1, LMNA, FEN1
12
Show member pathways
8.8RPA1, LMNA, FEN1
13
Show member pathways
8.7RPA1, POLB, FEN1
14
Show member pathways
7.8RPA1, BLM, WRN, FEN1, LMNA, RECQL4

Compounds for genes affiliated with Werner Syndrome

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45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR
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Compounds related to Werner Syndrome according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
18-oxoguanine459.8POLB, WRN
2polynucleotide459.7POLB, WRN
3phosphonate459.5TREX1, POLB
4camptothecin45 61 1111.4BLM, WRN, RPA1
5hydroxyurea45 51 1111.1RPA1, RECQL4, WRN, BLM
6hydrogen45 2410.0RPA1, GYPA, POLB
7cisplatin45 51 61 1111.5RPA1, POLB, FEN1, WRN
8magnesium45 24 1110.3BLM, WRN, FEN1, POLB, TREX1
9methylmethanesulfonate458.2RPA1, POLB, FEN1, WRN, BLM
10arginine458.2WRN, FEN1, POLB, LMNA, GYPA
11alanine458.1FEN1, POLB, LMNA, GYPA
12oligonucleotide458.0FEN1, POLB, GYPA, RPA1, TREX1
13atp45 298.3BLM, WRN, FEN1, POLB, LMNA, RPA1

GO Terms for genes affiliated with Werner Syndrome

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16Gene Ontology
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Cellular components related to Werner Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.5RPA1, BLM
2lateral elementGO:0008009.4RPA1, BLM
3male germ cell nucleusGO:0016739.2RPA1, BLM
4nucleoplasmGO:0056548.1WRN, FEN1, POLB, LMNA, RPA1
5nucleolusGO:0057307.2TREX1, BLM, WRN, FEN1, LMNA, RPA1
6nucleusGO:0056346.7BLM, FEN1, POLB, LMNA, RECQL4, RPA1

Biological processes related to Werner Syndrome according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1replication fork processingGO:03129710.0WRN, BLM
2DNA metabolic processGO:0062599.9TREX1, WRN
3DNA duplex unwindingGO:0325089.7BLM, WRN, RECQL4
4nucleotide-excision repair, DNA gap fillingGO:0062979.6POLB, RPA1
5DNA-dependent DNA replicationGO:0062619.6RPA1, POLB
6DNA catabolic process, exonucleolyticGO:0007389.5FEN1, TREX1
7cellular response to DNA damage stimulusGO:0069749.5POLB, WRN, BLM
8DNA strand renaturationGO:0007339.4BLM, RECQL4, RAD54L
9telomere maintenance via semi-conservative replicationGO:0322019.3FEN1, RPA1
10nucleic acid phosphodiester bond hydrolysisGO:0903059.3TREX1, FEN1, WRN
11double-strand break repair via homologous recombinationGO:0007249.2RAD54L, RPA1, BLM
12base-excision repairGO:0062849.2POLB, FEN1, WRN
13telomere maintenance via recombinationGO:0007229.1FEN1, RPA1
14double-strand break repairGO:0063029.1RPA1, FEN1, WRN
15DNA strand elongation involved in DNA replicationGO:0062719.0RPA1, FEN1
16meiotic nuclear divisionGO:0071269.0RAD54L, RPA1
17mitotic cell cycleGO:0002788.8RPA1, LMNA, FEN1
18telomere maintenanceGO:0007238.7RPA1, FEN1, WRN, BLM
19DNA replicationGO:0062608.4WRN, FEN1, RECQL4, RPA1, TREX1
20DNA recombinationGO:0063108.2TREX1, RAD54L, RPA1, RECQL4, WRN, BLM
21DNA repairGO:0062817.3BLM, FEN1, POLB, RECQL4, RPA1, RAD54L

Molecular functions related to Werner Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1four-way junction helicase activityGO:00937810.0WRN, BLM
2G-quadruplex DNA bindingGO:0518809.9WRN, BLM
33-5 exonuclease activityGO:0084089.9TREX1, WRN
4ATP-dependent DNA helicase activityGO:0040039.8BLM, WRN
5ATP-dependent 3-5 DNA helicase activityGO:0431409.7RECQL4, WRN, BLM
6bubble DNA bindingGO:0004059.7RECQL4, WRN, BLM
7exonuclease activityGO:0045279.5FEN1, WRN
8helicase activityGO:0043869.4RAD54L, WRN, BLM
9annealing helicase activityGO:0363109.3BLM, RECQL4, RAD54L
10single-stranded DNA bindingGO:0036979.3BLM, RPA1, TREX1
11manganese ion bindingGO:0301459.3FEN1, WRN
12damaged DNA bindingGO:0036848.9FEN1, POLB
13protein bindingGO:0055157.0RAD54L, RPA1, LMNA, POLB, FEN1, WRN

Products for genes affiliated with Werner Syndrome

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Werner Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet