MCID: WRN003
MIFTS: 47

Wernicke Encephalopathy

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

MalaCards integrated aliases for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 36 51 41 14 69
Wernicke's Encephalopathy 12 72
Wernicke-Korsakoff Syndrome 69
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
ICD10 32 E51.2
MeSH 41 D014899
KEGG 36 H01565
UMLS 69 C0043121

Summaries for Wernicke Encephalopathy

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke's encephalopathy, is related to cerebral beriberi and wernicke-korsakoff syndrome, and has symptoms including ophthalmoplegia and ataxia. An important gene associated with Wernicke Encephalopathy is SLC1A3 (Solute Carrier Family 1 Member 3), and among its related pathways/superpathways are Vitamin digestion and absorption and Transmission across Chemical Synapses. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and occipital lobe, and related phenotypes are behavior/neurological and cellular

Wikipedia : 72 Wernicke\'s encephalopathy (or Wernicke\'s disease) is the presence of neurological symptoms caused by... more...

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 cerebral beriberi 11.1
2 wernicke-korsakoff syndrome 11.1
3 encephalopathy 10.9
4 beriberi 10.2
5 dicarboxylic aminoaciduria 10.2 SLC1A2 SLC1A3
6 body mass index quantitative trait locus 11 10.1
7 body mass index quantitative trait locus 9 10.1
8 body mass index quantitative trait locus 8 10.1
9 body mass index quantitative trait locus 4 10.1
10 body mass index quantitative trait locus 10 10.1
11 body mass index quantitative trait locus 7 10.1
12 body mass index quantitative trait locus 12 10.1
13 body mass index quantitative trait locus 14 10.1
14 body mass index quantitative trait locus 18 10.1
15 lymphoma 10.1
16 pancreatitis 10.1
17 medulloepithelioma 10.1 GFAP INA
18 neuromyelitis optica 10.1 GFAP SLC1A2
19 gliomatosis cerebri 10.1 GFAP INA
20 medullomyoblastoma 10.0 GFAP INA
21 creutzfeldt-jakob disease 10.0
22 acute pancreatitis 10.0
23 neuronal ceroid-lipofuscinoses 10.0 GFAP SLC1A3
24 toxic encephalopathy 10.0 GFAP SLC1A2
25 graves disease 1 9.9
26 gastric cancer 9.9
27 infantile liver failure syndrome 1 9.9
28 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
29 hydrops, lactic acidosis, and sideroblastic anemia 9.9
30 liver cirrhosis 9.9
31 morbid obesity 9.9
32 cerebritis 9.9
33 central pontine myelinolysis 9.9
34 neuropathy 9.9
35 hepatic encephalopathy 9.9 GLUL SLC1A2
36 brain edema 9.8 GLUL SLC1A2
37 binswanger's disease 9.8 GFAP MAPT
38 hepatocellular carcinoma 9.8
39 multiple sclerosis 9.8
40 scleroderma, familial progressive 9.8
41 neuroblastoma 9.8
42 pancreatic cancer 9.8
43 cyclic vomiting syndrome 9.8
44 branchiootic syndrome 1 9.8
45 mycobacterium tuberculosis 1 9.8
46 bulimia nervosa 2 9.8
47 diabetes mellitus, ketosis-prone 9.8
48 acute liver failure 9.8
49 crohn's disease 9.8
50 leukemia 9.8

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ophthalmoplegia, ataxia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 SLC1A3 GAD1 TKT GFAP GLUL MAPT
2 cellular MP:0005384 9.73 SLC1A2 SLC1A3 GAD1 GFAP GLUL MAPT
3 mortality/aging MP:0010768 9.7 SLC1A3 GAD1 TKT GFAP GLUL MAPT
4 nervous system MP:0003631 9.56 SLC1A3 GAD1 TKT GFAP GLUL INA
5 normal MP:0002873 9.1 GAD1 GFAP GLUL INA MAPT SLC1A2

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3 59-43-8 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 3
4 Micronutrients Phase 4,Phase 3
5 Trace Elements Phase 4,Phase 3
6 Vitamin B Complex Phase 4,Phase 3
7 Thiamin Nutraceutical Phase 4,Phase 3
8 Folate Nutraceutical Phase 4,Phase 3
9 Vitamin B9 Nutraceutical Phase 4,Phase 3
10
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
11
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13 Gastrointestinal Agents Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Anesthetics Phase 3
16 Anesthetics, Local Phase 3
17 Anti-Allergic Agents Phase 3
18 Antiemetics Phase 3
19 Antipruritics Phase 3
20 Autonomic Agents Phase 3
21 Central Nervous System Depressants Phase 3
22 Dermatologic Agents Phase 3
23 Histamine Antagonists Phase 3
24 Histamine H1 Antagonists Phase 3
25
Histamine Phosphate Phase 3 51-74-1 65513
26 Hypnotics and Sedatives Phase 3
27 Neurotransmitter Agents Phase 3
28
Etanercept Approved, Investigational 185243-69-0
29
Adalimumab Approved 331731-18-1 16219006
30 Analgesics
31 Analgesics, Non-Narcotic
32 Anti-Inflammatory Agents
33 Anti-Inflammatory Agents, Non-Steroidal
34 Antirheumatic Agents
35 Immunosuppressive Agents
36 pyruvate Nutraceutical

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
3 Transcranial Magnetic Stimulation for "Voices" Completed NCT00308997 Phase 2
4 Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Recruiting NCT00567281 Phase 2
5 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207
6 Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke Unknown status NCT02101398
7 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
8 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Completed NCT02486302 Etanercept
9 Safety and Effect on Quality of Life/Work Productivity of Humira in Patients With Rheumatoid Arthritis Completed NCT01076205
10 MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection Planning Recruiting NCT01534104
11 Modeling Treated Recovery From Aphasia Recruiting NCT03416738
12 Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer Disease Active, not recruiting NCT03270137
13 The Effect of tDCS on Subcortical Brain Functioning Enrolling by invitation NCT01602276

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

38
Brain, Liver, Occipital Lobe, T Cells

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 190)
# Title Authors Year
1
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. ( 29307105 )
2018
2
Convergence Spasm in Wernicke Encephalopathy. ( 29276567 )
2018
3
Hypothermia Presenting in Wernicke Encephalopathy: A Case Report. ( 28289649 )
2017
4
Wernicke Encephalopathy ( 29261914 )
2017
5
Differences Between Alcoholic and Nonalcoholic Patients With Wernicke Encephalopathy: A Multicenter Observational Study. ( 28578781 )
2017
6
More than a Case Report? Should Wernicke Encephalopathy After Sleeve Gastrectomy be a Concern? ( 28733807 )
2017
7
A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy. ( 28367669 )
2017
8
Wernicke encephalopathy without delirium in patients with cancer. ( 28464962 )
2017
9
Optic Chiasm Involvement With Concurrent Typical Wernicke Encephalopathy Magnetic Resonance Findings: A Case Report. ( 29029866 )
2017
10
Wernicke Encephalopathy in a Patient with Pulmonary and Abdominal Tuberculosis. ( 29133769 )
2017
11
Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report. ( 28730572 )
2017
12
Fundus Findings in Wernicke Encephalopathy. ( 28924437 )
2017
13
Wernicke encephalopathy in a patient after liver transplantation: A case report. ( 29308003 )
2017
14
Malnutrition in the elderly and Wernicke encephalopathy. ( 28363380 )
2017
15
A patient with a 'typical presentation' of Wernicke encephalopathy was found to have sporadic Creutzfeldt-Jakob disease. ( 28653943 )
2017
16
A rare complication of vomiting in pregnancy: Wernicke encephalopathy. ( 28456382 )
2017
17
Wernicke encephalopathy and systemic sclerosis: rare association of rare conditions. ( 27590483 )
2016
18
Wernicke encephalopathy in a patient with liver failure: Clinical case report. ( 27399058 )
2016
19
Non-alcoholic Wernicke Encephalopathy. ( 26787276 )
2016
20
Wernicke encephalopathy as initial presentation of lymphoma. ( 26805632 )
2016
21
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
22
Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review. ( 27940680 )
2016
23
Gayet-Wernicke encephalopathy: A rare and serious complication of gastrointestinal involvement in HIV infection. ( 27079166 )
2016
24
Magnetic Resonance Imaging and H-proton Spectroscopy assessment of maternal and foetal brains in a case of pregnancy-associated Wernicke encephalopathy. ( 27624910 )
2016
25
Wernicke Encephalopathy after Restrictive Bariatric Surgery. ( 27097609 )
2016
26
Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo. ( 27799475 )
2016
27
Sleeve Gastrectomy and Wernicke Encephalopathy. ( 27415978 )
2016
28
Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases. ( 26869612 )
2016
29
Wernicke Encephalopathy after Restrictive Bariatric Surgery: A Significant Increase of a Rare Complication. ( 28234175 )
2016
30
Cerebral salt-wasting syndrome in a child with Wernicke encephalopathy treated with fludrocortisone therapy: A case report. ( 27603336 )
2016
31
Early detection and successful treatment of Wernicke encephalopathy in a patient with advanced carcinoma of the external genitalia during chemotherapy. ( 26653343 )
2016
32
Delayed diagnosis of Wernicke encephalopathy with irreversible neural damage after subtotal gastrectomy for gastric cancer: A case of medical liability? ( 27988455 )
2016
33
Nonalcoholic Wernicke Encephalopathy: An Entity Not to Be Missed! ( 27670213 )
2016
34
Wernicke Encephalopathy: a Future Problem Even After Sleeve Gastrectomy? A Systematic Literature Review. ( 26476834 )
2015
35
Wernicke Encephalopathy: A "Complication" of Acute Liver Failure. ( 26538061 )
2015
36
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
37
Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma. ( 26174546 )
2015
38
Wernicke Encephalopathy. ( 26564935 )
2015
39
Wernicke Encephalopathy and Sleeve Gastrectomy: A Case Report and Literature Review. ( 26539904 )
2015
40
Wernicke encephalopathy in a patient with severe acute pancreatitis. ( 26118580 )
2015
41
Wernicke encephalopathy as rare complication of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 26410803 )
2015
42
A Therapeutic Fast for Lymphoma Resulting in Wernicke Encephalopathy. ( 26104844 )
2015
43
Iatrogenic Wernicke Encephalopathy in a Patient With Severe Hyperemesis Gravidarum. ( 25774927 )
2015
44
Putamina involvement in Wernicke encephalopathy induced by Janus Kinase 2 inhibitor. ( 25970282 )
2015
45
Complex ophthalmoplaegia denoting Wernicke encephalopathy in a non-alcoholic individual. ( 25828145 )
2015
46
Diagnostic Clues to Human Herpesvirus 6 Encephalitis and Wernicke Encephalopathy After Pediatric Hematopoietic Cell Transplantation. ( 25564483 )
2015
47
Hearing loss in Wernicke encephalopathy. ( 29443160 )
2014
48
Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence. ( 24938142 )
2014
49
Clinical significance of mammillary body enhancement in Wernicke encephalopathy: report of 2 cases and review of the literature. ( 24769631 )
2014
50
Unusual complication in a paediatric patient: Wernicke encephalopathy associated with thiamine-deficient parenteral nutrition. ( 25444410 )
2014

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

Pathways related to Wernicke Encephalopathy according to KEGG:

36
# Name Kegg Source Accession
1 Vitamin digestion and absorption hsa04977

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.67 GFAP GLUL MAPT SLC1A3
2 axon GO:0030424 9.58 GAD1 MAPT SLC1A2
3 cytoplasmic ribonucleoprotein granule GO:0036464 9.48 INA MAPT
4 intermediate filament cytoskeleton GO:0045111 9.46 GFAP INA
5 axon terminus GO:0043679 9.43 GAD1 GLUL
6 cell body GO:0044297 9.33 GFAP GLUL MAPT
7 axolemma GO:0030673 9.32 MAPT SLC1A2
8 neurofilament GO:0005883 9.26 GFAP INA
9 glial cell projection GO:0097386 8.96 GFAP GLUL
10 myelin sheath GO:0043209 8.92 GFAP GLUL INA TKT

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.7 GAD1 SLC1A2 SLC1A3
2 chemical synaptic transmission GO:0007268 9.69 GAD1 SLC1A2 SLC1A3
3 amino acid transport GO:0006865 9.54 SLC1A2 SLC1A3
4 response to wounding GO:0009611 9.54 GFAP SLC1A2 SLC1A3
5 glutamate secretion GO:0014047 9.49 SLC1A2 SLC1A3
6 response to light stimulus GO:0009416 9.48 SLC1A2 SLC1A3
7 glutamate metabolic process GO:0006536 9.46 GLUL SLC1A3
8 L-glutamate transmembrane transport GO:0089711 9.43 SLC1A2 SLC1A3
9 L-glutamate transport GO:0015813 9.4 SLC1A2 SLC1A3
10 neurotransmitter uptake GO:0001504 9.32 GLUL SLC1A3
11 L-glutamate import across plasma membrane GO:0098712 9.26 SLC1A2 SLC1A3
12 glutamate catabolic process GO:0006538 9.16 GAD1 GLUL
13 D-aspartate import GO:0070779 8.96 SLC1A2 SLC1A3
14 gamma-aminobutyric acid biosynthetic process GO:0009449 8.62 GAD1 SLC1A3

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.37 SLC1A2 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
3 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A2 SLC1A3
4 glutamate decarboxylase activity GO:0004351 9.16 GAD1 GLUL
5 glutamate:sodium symporter activity GO:0015501 8.96 SLC1A2 SLC1A3
6 glutamate binding GO:0016595 8.8 GAD1 GLUL SLC1A3

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....