MCID: WRN003
MIFTS: 43

Wernicke Encephalopathy malady

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

Aliases & Descriptions for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 52 42 14 69
Wernicke-Korsakoff Syndrome 69
Wernicke's Encephalopathy 12
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
ICD10 33 E51.2
MeSH 42 D014899
UMLS 69 C0043121

Summaries for Wernicke Encephalopathy

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke-korsakoff syndrome, is related to cerebral beriberi and wernicke-korsakoff syndrome, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is SLC1A3 (Solute Carrier Family 1 Member 3), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuroscience. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and t cells, and related phenotypes are behavior/neurological and cellular

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 cerebral beriberi 11.0
2 wernicke-korsakoff syndrome 11.0
3 encephalopathy 10.8
4 thrombocythemia 3 10.2 SLC1A2 SLC1A3
5 male reproductive system disease 10.1 GFAP INA
6 childhood embryonal testis carcinoma 10.1 GFAP INA
7 niemann-pick disease 10.1 GFAP SLC1A2
8 childhood medulloblastoma 10.0 GFAP INA
9 peyronie's disease 10.0 GFAP SLC1A3
10 congenital hypoplastic anemia 10.0 GLUL SLC1A2
11 obesity 10.0
12 pancreatitis 10.0
13 lymphoma 10.0
14 benign partial epilepsy with secondarily generalized seizures in infancy 10.0 MAPT SLC1A2
15 histiocytoid hemangioma 10.0 GLUL SLC1A2
16 deafness, autosomal recessive 101 9.9 GFAP MAPT
17 acute pancreatitis 9.9
18 bone dysplasia azouz type 9.9 GFAP MAPT
19 ovarian mucinous adenocarcinoma 9.9 GFAP SLC1A2
20 anterograde amnesia 9.9 GFAP GLUL
21 neurosarcoidosis 9.9 MAPT SLC1A2 SLC1A3
22 central pontine myelinolysis 9.8
23 creutzfeldt-jakob disease 9.8
24 neuropathy 9.8
25 liver cirrhosis 9.8
26 morbid obesity 9.8
27 cerebritis 9.8
28 autism 19 9.8 GFAP MAPT
29 mucopolysaccharidosis iv 9.8 INA MAPT SLC1A2
30 retinitis 9.7
31 anorexia nervosa 9.7
32 pancreatic cancer 9.7
33 t-cell leukemia 9.7
34 acute liver failure 9.7
35 neuronitis 9.7
36 crohn's disease 9.7
37 pellagra 9.7
38 gastric cancer 9.7
39 duodenitis 9.7
40 leukemia 9.7
41 encephalitis 9.7
42 cyclic vomiting syndrome 9.7
43 sensorineural hearing loss 9.7
44 tremor 9.7
45 beriberi 9.7
46 neuroblastoma 9.7
47 hepatocellular carcinoma 9.7
48 thalassemia 9.5 GAD1 GFAP GLUL SLC1A2 SLC1A3
49 long qt syndrome 5 9.5 GFAP INA MAPT SLC1A2 SLC1A3
50 ovarian cancer 8.9 GAD1 GFAP GLUL INA MAPT SLC1A2

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 GAD1 GFAP GLUL MAPT SLC1A2 SLC1A3
2 cellular MP:0005384 9.73 GAD1 GFAP GLUL MAPT SLC1A2 SLC1A3
3 mortality/aging MP:0010768 9.7 SLC1A2 SLC1A3 TKT GAD1 GFAP GLUL
4 nervous system MP:0003631 9.56 GAD1 GFAP GLUL INA MAPT SLC1A2
5 normal MP:0002873 9.1 GAD1 GFAP GLUL INA MAPT SLC1A2

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-43-8 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 3
4 Micronutrients Phase 4,Phase 3
5 Trace Elements Phase 4,Phase 3
6 Vitamin B Complex Phase 4,Phase 3
7 Thiamin Nutraceutical Phase 4,Phase 3
8 Folate Nutraceutical Phase 4,Phase 3
9 Vitamin B9 Nutraceutical Phase 4,Phase 3
10
Diphenhydramine Approved Phase 3 58-73-1, 147-24-0 3100
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Promethazine Approved Phase 3 60-87-7 4927
13 Gastrointestinal Agents Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Anesthetics Phase 3
16 Anesthetics, Local Phase 3
17 Anti-Allergic Agents Phase 3
18 Antiemetics Phase 3
19 Antipruritics Phase 3
20 Autonomic Agents Phase 3
21 Central Nervous System Depressants Phase 3
22 Dermatologic Agents Phase 3
23 Histamine Antagonists Phase 3
24 Histamine H1 Antagonists Phase 3
25
Histamine Phosphate Phase 3 51-74-1 65513
26 Hypnotics and Sedatives Phase 3
27 Neurotransmitter Agents Phase 3
28
Etanercept Approved, Investigational 185243-69-0
29
Adalimumab Approved 331731-18-1 16219006
30
Pyruvate Approved, Nutraceutical
31 Analgesics
32 Analgesics, Non-Narcotic
33 Anti-Inflammatory Agents
34 Anti-Inflammatory Agents, Non-Steroidal
35 Antirheumatic Agents
36 Immunosuppressive Agents

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4
2 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3
3 Transcranial Magnetic Stimulation for "Voices" Completed NCT00308997 Phase 2
4 Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Recruiting NCT00567281 Phase 2
5 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207
6 Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke Unknown status NCT02101398
7 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
8 MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection Planning Recruiting NCT01534104
9 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Recruiting NCT02486302
10 Safety and Effect on Quality of Life/Work Productivity of Humira in Patients With Rheumatoid Arthritis Recruiting NCT01076205
11 The Effect of tDCS on Subcortical Brain Functioning Enrolling by invitation NCT01602276

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

39
Brain, Liver, T Cells, Occipital Lobe

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 172)
id Title Authors Year
1
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
2
Wernicke Encephalopathy after Restrictive Bariatric Surgery. ( 27097609 )
2016
3
Wernicke encephalopathy in a patient with liver failure: Clinical case report. ( 27399058 )
2016
4
Non-alcoholic Wernicke Encephalopathy. ( 26787276 )
2016
5
Sleeve Gastrectomy and Wernicke Encephalopathy. ( 27415978 )
2016
6
Cerebral salt-wasting syndrome in a child with Wernicke encephalopathy treated with fludrocortisone therapy: A case report. ( 27603336 )
2016
7
Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review. ( 27940680 )
2016
8
Early detection and successful treatment of Wernicke encephalopathy in a patient with advanced carcinoma of the external genitalia during chemotherapy. ( 26653343 )
2016
9
Wernicke encephalopathy as initial presentation of lymphoma. ( 26805632 )
2016
10
Gayet-Wernicke encephalopathy: A rare and serious complication of gastrointestinal involvement in HIV infection. ( 27079166 )
2016
11
Nonalcoholic Wernicke Encephalopathy: An Entity Not to Be Missed! ( 27670213 )
2016
12
Wernicke encephalopathy and systemic sclerosis: rare association of rare conditions. ( 27590483 )
2016
13
Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo. ( 27799475 )
2016
14
Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases. ( 26869612 )
2016
15
Delayed diagnosis of Wernicke encephalopathy with irreversible neural damage after subtotal gastrectomy for gastric cancer: A case of medical liability? ( 27988455 )
2016
16
Magnetic Resonance Imaging and H-proton Spectroscopy assessment of maternal and foetal brains in a case of pregnancy-associated Wernicke encephalopathy. ( 27624910 )
2016
17
Wernicke encephalopathy in a patient with severe acute pancreatitis. ( 26118580 )
2015
18
Putamina involvement in Wernicke encephalopathy induced by Janus Kinase 2 inhibitor. ( 25970282 )
2015
19
Complex ophthalmoplaegia denoting Wernicke encephalopathy in a non-alcoholic individual. ( 25828145 )
2015
20
Wernicke Encephalopathy and Sleeve Gastrectomy: A Case Report and Literature Review. ( 26539904 )
2015
21
Iatrogenic Wernicke Encephalopathy in a Patient With Severe Hyperemesis Gravidarum. ( 25774927 )
2015
22
Wernicke Encephalopathy: A "Complication" of Acute Liver Failure. ( 26538061 )
2015
23
A Therapeutic Fast for Lymphoma Resulting in Wernicke Encephalopathy. ( 26104844 )
2015
24
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
25
Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma. ( 26174546 )
2015
26
Wernicke Encephalopathy: a Future Problem Even After Sleeve Gastrectomy? A Systematic Literature Review. ( 26476834 )
2015
27
Diagnostic Clues to Human Herpesvirus 6 Encephalitis and Wernicke Encephalopathy After Pediatric Hematopoietic Cell Transplantation. ( 25564483 )
2015
28
Wernicke encephalopathy as rare complication of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 26410803 )
2015
29
Wernicke Encephalopathy. ( 26564935 )
2015
30
Coexisting cytotoxic and vasogenic edema in Wernicke encephalopathy. ( 24469347 )
2014
31
Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy. ( 25539041 )
2014
32
Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence. ( 24938142 )
2014
33
Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. ( 25201422 )
2014
34
Unusual complication in a paediatric patient: Wernicke encephalopathy associated with thiamine-deficient parenteral nutrition. ( 25444410 )
2014
35
Imaging-based diagnosis of wernicke encephalopathy: a case report. ( 25717447 )
2014
36
The pathological features of Wernicke encephalopathy. ( 24469889 )
2014
37
Bilateral Midbrain and Thalamic Hemorrhage in Wernicke Encephalopathy. ( 26693540 )
2014
38
Wernicke encephalopathy in subjects undergoing restrictive weight loss surgery: a systematic review of literature data. ( 24764323 )
2014
39
Wernicke Encephalopathy due to Thiamine Deficiency After Surgery on a Child With Duodenal Stenosis. ( 25303868 )
2014
40
Clinical significance of mammillary body enhancement in Wernicke encephalopathy: report of 2 cases and review of the literature. ( 24769631 )
2014
41
Wernicke encephalopathy in children and adolescents. ( 25515801 )
2014
42
Wernicke encephalopathy and ethanol-related syndromes. ( 24745886 )
2014
43
Wernicke encephalopathy after Roux-en-Y gastric bypass and hyperemesis gravidarum. ( 23932007 )
2013
44
MR spectroscopy in pediatric Wernicke encephalopathy. ( 23460620 )
2013
45
Teaching NeuroImages: Wernicke encephalopathy: diagnostically deceptive but treatable. ( 23439708 )
2013
46
Wernicke encephalopathy: a medical emergency. ( 24016788 )
2013
47
Wernicke encephalopathy following nutritional deficiency in a patient with multiple trauma. ( 24180735 )
2013
48
Recurrent Wernicke encephalopathy in an adolescent female following laparoscopic gastric bypass surgery. ( 23559489 )
2013
49
Wernicke encephalopathy after surgery for morbid obesity. ( 24340850 )
2013
50
A case of Wernicke encephalopathy combined with disulfiram intoxication. ( 23812173 )
2013

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.43 GAD1 MAPT SLC1A2
2 cell body GO:0044297 9.4 GLUL MAPT
3 axon terminus GO:0043679 9.37 GAD1 GLUL
4 intermediate filament cytoskeleton GO:0045111 9.32 GFAP INA
5 cytoplasmic ribonucleoprotein granule GO:0036464 9.16 INA MAPT
6 myelin sheath GO:0043209 9.13 GLUL INA TKT
7 axolemma GO:0030673 8.62 MAPT SLC1A2

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.69 GAD1 SLC1A2 SLC1A3
2 chemical synaptic transmission GO:0007268 9.67 GAD1 SLC1A2 SLC1A3
3 response to wounding GO:0009611 9.52 SLC1A2 SLC1A3
4 glutamate secretion GO:0014047 9.48 SLC1A2 SLC1A3
5 response to light stimulus GO:0009416 9.46 SLC1A2 SLC1A3
6 glutamate metabolic process GO:0006536 9.43 GLUL SLC1A3
7 L-glutamate transmembrane transport GO:0089711 9.4 SLC1A2 SLC1A3
8 L-glutamate transport GO:0015813 9.37 SLC1A2 SLC1A3
9 neurotransmitter uptake GO:0001504 9.32 GLUL SLC1A3
10 glutamate catabolic process GO:0006538 9.26 GAD1 GLUL
11 D-aspartate import GO:0070779 9.16 SLC1A2 SLC1A3
12 L-glutamate import GO:0051938 8.96 SLC1A2 SLC1A3
13 gamma-aminobutyric acid biosynthetic process GO:0009449 8.62 GAD1 SLC1A3

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.37 SLC1A2 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
3 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A2 SLC1A3
4 glutamate decarboxylase activity GO:0004351 9.16 GAD1 GLUL
5 glutamate:sodium symporter activity GO:0015501 8.96 SLC1A2 SLC1A3
6 glutamate binding GO:0016595 8.8 GAD1 GLUL SLC1A3

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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