MCID: WRN003
MIFTS: 44

Wernicke Encephalopathy malady

Categories: Metabolic diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Wernicke Encephalopathy

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Aliases & Descriptions for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 11 50 39 13 68
Wernicke-Korsakoff Syndrome 68
 
Wernicke's Encephalopathy 11
Wernicke's Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:2384
ICD1030 E51.2
MeSH39 D014899

Summaries for Wernicke Encephalopathy

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Disease Ontology:11 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

MalaCards based summary: Wernicke Encephalopathy, also known as wernicke-korsakoff syndrome, is related to cerebral beriberi and encephalopathy, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is SLC1A3 (Solute Carrier Family 1 Member 3), and among its related pathways are Alanine, aspartate and glutamate metabolism and Neurotransmitter Release Cycle. The drugs thiamine mononitrate and thiamine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and liver, and related mouse phenotypes are cellular and growth/size/body region.

Related Diseases for Wernicke Encephalopathy

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Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral beriberi11.0
2encephalopathy10.8
3newborn respiratory distress syndrome10.1GFAP, SLC1A2
4ependymoblastoma10.1GFAP, INA
5uterine corpus epithelioid leiomyosarcoma10.1GFAP, INA
6adult central nervous system primitive neuroectodermal neoplasm10.1GFAP, INA
7ovarian mucinous cystadenocarcinoma10.1GFAP, SLC1A2
8neurogenic bowel10.0GLUL, SLC1A2
9obesity10.0
10lymphoma10.0
11pancreatitis10.0
12atrophic rhinitis10.0GLUL, SLC1A2
13acute pancreatitis9.9
14dental pulp disease9.9GFAP, GLUL
15creutzfeldt-jakob disease9.9
16liver cirrhosis9.9
17morbid obesity9.9
18cerebritis9.9
19central pontine myelinolysis9.9
20neuropathy9.9
21testicular lymphoma9.7GAD1, GFAP, SLC1A2
22neuroblastoma9.7
23hepatocellular carcinoma9.7
24anorexia nervosa9.7
25pancreatic cancer9.7
26acute liver failure9.7
27crohn's disease9.7
28gastric cancer9.7
29leukemia9.7
30sensorineural hearing loss9.7
31beriberi9.7
32retinitis9.7
33t-cell leukemia9.7
34neuronitis9.7
35pellagra9.7
36duodenitis9.7
37encephalitis9.7
38cyclic vomiting syndrome9.7
39tremor9.7
40pick disease9.7INA, MAPT
41polycystic kidney disease 29.6GFAP, MAPT
42myoclonic encephalopathy of infants9.6MAPT, SLC1A2, SLC1A3
43mucopolysaccharidosis iii9.6MAPT, SLC1A2
44avoidant personality disorder9.5GAD1, MAPT
45angiomyolipoma9.5GFAP, MAPT
46purpura9.5GFAP, GLUL
47long qt syndrome 58.7GFAP, INA, MAPT, SLC1A2, SLC1A3
48glandular cystitis7.9GFAP, GLUL, INA, MAPT, SLC1A2, SLC1A3

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to wernicke encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

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UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1GAD1, GFAP, GLUL, MAPT, SLC1A2, SLC1A3
2MP:00053788.0GAD1, GFAP, GLUL, MAPT, SLC1A2, TKT
3MP:00053867.7GAD1, GFAP, GLUL, MAPT, SLC1A2, SLC1A3
4MP:00107687.6GAD1, GFAP, GLUL, MAPT, SLC1A2, SLC1A3
5MP:00036317.1GAD1, GFAP, GLUL, INA, MAPT, SLC1A2
6MP:00028737.1GAD1, GFAP, GLUL, INA, MAPT, SLC1A2

Drugs & Therapeutics for Wernicke Encephalopathy

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Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Thiamineapproved, nutraceutical, vet_approvedPhase 4, Phase 39859-43-81130
Synonyms:
100660-17-1
115461-66-0
1sbr
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydrox yethyl)-4-methylthiazolium chloride
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethylthiazolium chloride, monohydrochloride
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride monohydrochloride
3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM
3-(4-AMINO-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride
3[(4-Amino-2-methyl-5-pyrimidinyl)-methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride
55463-15-5
57777-32-9
59-43-8
67-03-8
AC-11683
AC1L1ASK
AC1L1LOC
AC1LAODT
AC1Q4V9Q
AI3-18993
AKOS000668650
AR-1L8201
Aneurin
Aneurine
Antiberiberi factor
Apatate drape
Apate drops
B-Amin
BAS 00266240
BPBio1_000686
BSPBio_000622
Beatine
Bedome
Begiolan
Beivon
Benerva
Bequin
Berin
Betabion
Betalin S
Betaxin
Bethiamin
Bethiazine
Beuion
Bevitex
Bevitine
Bewon
Biamine
Bithiamin
Biuno
Bivatin
Bivita
C00378
C12H17N4OS
CCRIS 1906
CCRIS 5823
CHEBI:18385
CHEBI:33283
CHEBI:49105
CHEMBL1547
CHEMBL1588
CID1130
CID517305
CID6042
Cernevit-12
Chloride-hydrochloride salt of thiamine
Clotiamina
D08580
DB00152
EINECS 200-425-3
EINECS 200-641-8
Eskapen
Eskaphen
FEMA No. 3322
 
HSDB 220
Hybee
I14-14339
LS-3226
LT00233141
Lixa-beta
MLS001304099
Metabolin
MolPort-000-722-048
MolPort-001-920-086
MolPort-002-052-059
NChemBio.2007.13-comp10
NSC 36226
NSC36226
Oryzanin
Oryzanine
Prestwick0_000631
Prestwick1_000631
Prestwick2_000631
Prestwick3_000631
SBB058094
SMP1_000084
SMR000718788
SPBio_002841
ST095175
Slowten
THD
THIAMIN, VITAMIN B1
Thiadoxine
Thiamin
Thiamin dichloride
Thiaminal
Thiamine
Thiamine (INN)
Thiamine HCL
Thiamine [INN:BAN]
Thiamine chloride
Thiamine chloride hydrochloride
Thiamine dichloride
Thiamine hydrochloride [JAN]
Thiamine monochloride
Thiamine monohydrochloride
Thiamine, chloride
Thiamine, chloride, hydrochloride
Thiamine, monohydrochloride
Thiaminium
Thiaminium chloride hydrochloride
Thiaminum
Thiaminum [INN-Latin]
Thiamol
Thiavit
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethyl, chloride, monohydrochloride
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride (1:1)
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, monohydrochloride
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-chloride
Tiamidon
Tiamina
Tiamina [INN-Spanish]
Tiaminal
TimTec1_000613
Trophite
UNII-X66NSO3N35
VIB
Vetalin S
Vinothiam
Vitamin B1
Vitamin B1 (TN)
Vitamin B1 hydrochloride (VAN)
Vitaneurin
Vitaneuron
ZINC00049153
[5-[[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methylpyrimidin-4-yl]azanium dichloride
bmse000274
nchembio.121-comp5
thiamin
thiamine
thiamine(1+)
thiamine(1+) ion
thiaminium
vitamin B1
vitamin b1(thiamine)
2
Folic Acidapproved, nutraceutical, vet_approvedPhase 4, Phase 3427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
3VitaminsPhase 4, Phase 35095
4Vitamin B ComplexPhase 4, Phase 34229
5Trace ElementsPhase 4, Phase 35802
6MicronutrientsPhase 4, Phase 35802
7ThiaminNutraceuticalPhase 4, Phase 398
8FolateNutraceuticalPhase 4, Phase 34279
9Vitamin B9NutraceuticalPhase 4, Phase 34279
10
HistamineapprovedPhase 3103475614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
11
PromethazineapprovedPhase 322560-87-74927
Synonyms:
(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
(Dimethylamino-2-propyl-10-phenothiazine hydrochloride
10-(2-(Dimethylamino)-2-methylethyl)phenothiazine
10-(2-(Dimethylamino)propyl)phenothiazine
10-(2-Dimethylaminopropyl)phenothiazine
10-[2-(Dimethylamino)propyl]phenothiazine
10-[2-(dimethylamino)Propyl]phenothiazine
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl- (9CI)
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, radical ion(1+)
3277 RP
3389 R.p.
38878-40-9
4-27-00-01253 (Beilstein Handbook Reference)
4182 R.p.
60-87-7
73745-50-3
A-91033
AB00053535
AC-15939
AC1L1J92
Antiallersin
Aprobit
Avomine
BPBio1_000744
BRN 0088554
BSPBio_000676
BSPBio_002777
C07404
CCRIS 7056
CHEBI:8461
CHEMBL643
CID4927
Camergan
D00494
DB01069
Dimapp
Dimethylamino-isopropyl-phenthiazin
Dimethylamino-isopropyl-phenthiazin [German]
Diphergan
Diprazin
Diprazine
Diprozin
DivK1c_000005
EINECS 200-489-2
Fargan
Fenazil
Fenetazina
Fenetazine
Genphen
HMS2089E08
HSDB 3173
Hiberna
Histargan
IDI1_000005
Iergigan
InChI=1/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
Isophenergan
Isopromethazine
KBio1_000005
KBio2_001348
KBio2_003916
KBio2_006484
KBio3_001997
KBioGR_001697
KBioSS_001348
L000495
LS-264
Lercigan
Lergigan
Lilly 01516
Lilly 1516
Lopac0_000899
Metaryl
MolPort-001-783-684
N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine
N,N,╬▒-trimethyl-10H-phenothiazine-10-ethanamine
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
 
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride
N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine
N-(2'-dimethylamino-2'-Methyl)ethylphenothiazine
N-Dimethylamino-2-methylethyl thiodiphenylamine
NCGC00015817-10
NCGC00089735-02
NCGC00089735-03
NCI-C60673
NCI60_001878
NINDS_000005
NSC 30321
NSC30321
Oprea1_758749
PROMETHAZINE (SEE ALSO PROMETHAZINE HYDROCHLORIDE 58-33-3)
Pelpica
Phargan
Phenargan
Phenerzine
Phenoject-50
Phensedyl
Pilothia
Pilpophen
Pipolphene
Prestwick0_000888
Prestwick1_000888
Prestwick2_000888
Prestwick3_000888
Pro-50
Proazaimine
Proazamine
Procit
Promacot
Promazinamide
Promergan
Promesan
Prometasin
Prometazin
Prometazina
Prometazina [INN-Spanish]
Prometazine
Prometh
Promethacon
Promethaine
Promethazin
Promethazine
Promethazine (JAN/INN)
Promethazine [INN:BAN]
PromethazineHcl
Promethazinum
Promethazinum [INN-Latin]
Promethegan
Promethiazine
Promezathine
Prorex
Protazine
Prothazin
Prothazine
Provigan
Pyrethia
Pyrethiazine
RP 3277
Remsed
Romergan
Rumergan
SKF 1498
SPBio_000799
SPBio_002895
Spectrum2_000840
Spectrum3_001019
Spectrum4_001149
Spectrum5_000977
Spectrum_000868
Tanidil
Thiergan
UNII-FF28EJQ494
Valergine
Vallergine
WLN: T C666 BN ISJ B1Y1&N1&1
WY 509
Zipan-25
promethazine
12
Histamine PhosphateapprovedPhase 3103351-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
13
DiphenhydramineapprovedPhase 322558-73-1, 147-24-03100
Synonyms:
147-24-0
147-24-0 (HYDROCHLORIDE)
2-(Benzhydryloxy)-N,N-dimethylethylamine
2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride
2-(Diphenylmethoxy)-N,N-dimethylethylamine
2-(diphenylmethoxy)-N,N-dimethylethanamine
2-Diphenylmethoxy-N,N-dimethylethylamine
2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine
2-benzhydryloxy-N,N-dimethylethanamine
2-benzhydryloxyethyl-N,N-dimethylammonium
2-diphenylmethoxy-N,N-demthylethanamine
2PM
58-73-1
88637-37-0 (citrate (1:1))
AB00053460
AC-13704
AC1L1F65
AKOS003658554
Aleryl
Alledryl
Aller-Med
Allerdryl
Allergan
Allergan B
Allergeval
Allergical
Allergina
Allergival
Allermax Caplets
Amidryl
Antistominum
Antitussive
Antomin
Automin
BENADRYL HCl
BIDD:GT0152
BPBio1_000275
BRD-K47278471-003-05-7
BRN 1914136
BSPBio_000249
BSPBio_002219
Bagodryl
Banophen
Banophen Caplets
Baramine
Beldin
Belix
Ben-allergin
Bena
Benachlor
Benadrin
Benadryl
Benadryl (hydrochloride)
Benadryl Allergy
Benapon
Bendylate
Benhydramin
Benodin
Benodine
Benylan
Benylin
Benzantin
Benzantine
Benzhydramine
Benzhydraminum
Benzhydril
Benzhydroamina
Benzhydryl
Betramin
CAS-147-24-0
CCRIS 1959
CHEBI:127629
CHEBI:4636
CHEMBL657
CID3100
CPD-10890
Compoz
D00300
DB01075
DB06975
DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE
Dabylen
Debendrin
Dermistina
Dermodrin
Desentol
Diabenyl
Diabylen
Dibendrin
Dibenil
Dibondrin
Difedryl
Difenhidramina
Difenhidramina [INN-Spanish]
Difenhydramin
Difenhydramine
Difenidramina
Difenidramina [Italian]
Dihidral
Dimedrol
Dimedrol base
Dimedrolum
Dimedryl
Dimehydrinate
Dimethylamine benzhydryl ester
Diphamine
Diphantine
Diphen
 
Diphen Cough
Diphenhist
Diphenhist Captabs
Diphenhydramine
Diphenhydramine (JP15/INN)
Diphenhydramine Base
Diphenhydramine HCl
Diphenhydramine [INN:BAN:JAN]
Diphenhydraminum
Diphenhydraminum [INN-Latin]
Diphenylhydramin
Diphenylhydramine
DivK1c_000368
Dobacen
Dormarex 2
Dryistan
Drylistan
Dylamon
EINECS 200-396-7
Etanautine
FAR 90X2
Genahist
HMS2089E06
HSDB 3066
Histaxin
Hyadrine
Hydramine
Hyrexin
I14-6749
IDI1_000368
Ibiodral
KBio1_000368
KBio2_001460
KBio2_004028
KBio2_006596
KBio3_001439
KBioGR_001099
KBioSS_001460
L000227
LS-68208
Lopac-D-3630
Lopac0_000377
MLS002222276
Medidryl
Mephadryl
MolPort-001-783-508
N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride
N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine
N-(Benzhydryloksy-etylo)dwumetyloamina
N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]
N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE
NCGC00015335-01
NCGC00015335-02
NCGC00015335-03
NCGC00015335-10
NCGC00024414-03
NCGC00024414-04
NCI60_002916
NCI60_022782
NINDS_000368
NSC665800
Nausen
Nervine Nighttime Sleep-Aid
Novamina
Nytol Quickcaps
Nytol Quickgels
O-Benzhydryldimethylaminoethanol
O-benzhydryldimethylaminoethanol
Oprea1_254625
PM 255
Prestwick0_000065
Prestwick1_000065
Prestwick2_000065
Prestwick3_000065
Probedryl
Restamin
Restamin (TN)
Rigidil
S51
SMR001307259
SPBio_000961
SPBio_002170
STK103720
STOCK2S-94461
Siladryl
Silphen
Sleep-Eze D
Sleep-Eze D Extra Strength
Spectrum2_000961
Spectrum3_000400
Spectrum4_000520
Spectrum5_000915
Spectrum_000980
Syntedril
Syntodril
TL8003758
Twilite Caplets
UNII-8GTS82S83M
Unisom Sleepgels Maximum Strength
alpha-(2-Dimethylaminoethoxy)diphenylmethane
beta-Dimethylamino-aethyl-benzhydryl-aether
beta-Dimethylamino-aethyl-benzhydryl-aether [German]
beta-Dimethylaminoethanol diphenylmethyl ether
beta-Dimethylaminoethyl benzhydryl ether
beta-Dimethylaminoethylbenzhydrylether
beta-dimethylaminoethyl benzhydryl ether
diphenhydramine
nchembio747-comp18
╬▓-dimethylaminoethyl benzhydryl ether
14Gastrointestinal AgentsPhase 38109
15Peripheral Nervous System AgentsPhase 322776
16Anesthetics, LocalPhase 33272
17AntipruriticsPhase 3864
18Neurotransmitter AgentsPhase 317734
19AnestheticsPhase 39001
20Histamine H1 AntagonistsPhase 3782
21Hypnotics and SedativesPhase 32485
22Autonomic AgentsPhase 39774
23Histamine AntagonistsPhase 3946
24Central Nervous System DepressantsPhase 312806
25Dermatologic AgentsPhase 35674
26Anti-Allergic AgentsPhase 31490
27AntiemeticsPhase 33888
28
Etanerceptapproved, investigational397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
29Pyruvateapproved, Nutraceutical38
30Analgesics11287
31Immunosuppressive Agents12770
32Antirheumatic Agents10627
33Anti-Inflammatory Agents, Non-Steroidal4295
34Anti-Inflammatory Agents10355
35Analgesics, Non-Narcotic6260

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Optimum Thiamine Intervention (OpTIn) TrialRecruitingNCT02788552Phase 4
2Cesium-131 Seed Brachytherapy Plus Subtotal Resection for Lung Cancer PatientsRecruitingNCT01757158Phase 4
3Does Thiamine Help Vomiting and Nausea in Pregnancy?TerminatedNCT00861523Phase 3
4Transcranial Magnetic Stimulation for "Voices"CompletedNCT00308997Phase 2
5Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory HallucinationsRecruitingNCT00567281Phase 2
6From Uncomplicated Alcoholism to Korsakoff's SyndromeUnknown statusNCT01455207
7Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their StrokeUnknown statusNCT02101398
8Models of Disordered Knowledge and Memory Systems in Dementia and Related DisordersCompletedNCT00004557
9MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection PlanningRecruitingNCT01534104
10A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis.RecruitingNCT02486302
11The Effect of tDCS on Subcortical Brain FunctioningEnrolling by invitationNCT01602276

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

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Anatomical Context for Wernicke Encephalopathy

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MalaCards organs/tissues related to Wernicke Encephalopathy:

36
Brain, Lung, Liver, Occipital lobe, T cells

Publications for Wernicke Encephalopathy

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Articles related to Wernicke Encephalopathy:

(show top 50)    (show all 172)
idTitleAuthorsYear
1
Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review. (27940680)
2016
2
Cerebral salt-wasting syndrome in a child with Wernicke encephalopathy treated with fludrocortisone therapy: A case report. (27603336)
2016
3
Magnetic Resonance Imaging and H-proton Spectroscopy assessment of maternal and foetal brains in a case of pregnancy-associated Wernicke encephalopathy. (27624910)
2016
4
Sleeve Gastrectomy and Wernicke Encephalopathy. (27415978)
2016
5
Wernicke encephalopathy in a patient with liver failure: Clinical case report. (27399058)
2016
6
Nonalcoholic Wernicke Encephalopathy: An Entity Not to Be Missed! (27670213)
2016
7
Wernicke Encephalopathy after Restrictive Bariatric Surgery. (27097609)
2016
8
Wernicke encephalopathy as initial presentation of lymphoma. (26805632)
2016
9
Early detection and successful treatment of Wernicke encephalopathy in a patient with advanced carcinoma of the external genitalia during chemotherapy. (26653343)
2016
10
Non-alcoholic Wernicke Encephalopathy. (26787276)
2016
11
Gayet-Wernicke encephalopathy: A rare and serious complication of gastrointestinal involvement in HIV infection. (27079166)
2016
12
Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo. (27799475)
2016
13
Delayed diagnosis of Wernicke encephalopathy with irreversible neural damage after subtotal gastrectomy for gastric cancer: A case of medical liability? (27988455)
2016
14
Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases. (26869612)
2016
15
Wernicke encephalopathy and systemic sclerosis: rare association of rare conditions. (27590483)
2016
16
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. (27515947)
2016
17
Complex ophthalmoplaegia denoting Wernicke encephalopathy in a non-alcoholic individual. (25828145)
2015
18
Wernicke Encephalopathy: a Future Problem Even After Sleeve Gastrectomy? A Systematic Literature Review. (26476834)
2015
19
Wernicke Encephalopathy and Sleeve Gastrectomy: A Case Report and Literature Review. (26539904)
2015
20
Iatrogenic Wernicke Encephalopathy in a Patient With Severe Hyperemesis Gravidarum. (25774927)
2015
21
Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma. (26174546)
2015
22
Diagnostic Clues to Human Herpesvirus 6 Encephalitis and Wernicke Encephalopathy After Pediatric Hematopoietic Cell Transplantation. (25564483)
2015
23
Wernicke Encephalopathy: A "Complication" of Acute Liver Failure. (26538061)
2015
24
Wernicke Encephalopathy. (26564935)
2015
25
Wernicke encephalopathy as rare complication of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. (26410803)
2015
26
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. (26490997)
2015
27
A Therapeutic Fast for Lymphoma Resulting in Wernicke Encephalopathy. (26104844)
2015
28
Wernicke encephalopathy in a patient with severe acute pancreatitis. (26118580)
2015
29
Putamina involvement in Wernicke encephalopathy induced by Janus Kinase 2 inhibitor. (25970282)
2015
30
Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy. (25539041)
2014
31
Imaging-based diagnosis of wernicke encephalopathy: a case report. (25717447)
2014
32
Wernicke encephalopathy and ethanol-related syndromes. (24745886)
2014
33
Wernicke encephalopathy in subjects undergoing restrictive weight loss surgery: a systematic review of literature data. (24764323)
2014
34
Clinical significance of mammillary body enhancement in Wernicke encephalopathy: report of 2 cases and review of the literature. (24769631)
2014
35
Wernicke encephalopathy in children and adolescents. (25515801)
2014
36
Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence. (24938142)
2014
37
Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. (25201422)
2014
38
The pathological features of Wernicke encephalopathy. (24469889)
2014
39
Bilateral Midbrain and Thalamic Hemorrhage in Wernicke Encephalopathy. (26693540)
2014
40
Unusual complication in a paediatric patient: Wernicke encephalopathy associated with thiamine-deficient parenteral nutrition. (25444410)
2014
41
Coexisting cytotoxic and vasogenic edema in Wernicke encephalopathy. (24469347)
2014
42
Wernicke Encephalopathy due to Thiamine Deficiency After Surgery on a Child With Duodenal Stenosis. (25303868)
2014
43
Recurrent Wernicke encephalopathy in an adolescent female following laparoscopic gastric bypass surgery. (23559489)
2013
44
Wernicke Encephalopathy in Pediatric Neuro-oncology: Presentation of 2 Cases and Review of Literature. (24293308)
2013
45
MR spectroscopy in pediatric Wernicke encephalopathy. (23460620)
2013
46
Wernicke encephalopathy after surgery for morbid obesity. (24340850)
2013
47
A case of Wernicke encephalopathy combined with disulfiram intoxication. (23812173)
2013
48
Brain MRI findings in Wernicke encephalopathy. (24195023)
2013
49
Wernicke encephalopathy after surgery for morbid obesity. (24340851)
2013
50
Wernicke encephalopathy: a medical emergency. (24016788)
2013

Variations for Wernicke Encephalopathy

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Expression for genes affiliated with Wernicke Encephalopathy

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Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for genes affiliated with Wernicke Encephalopathy

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GO Terms for genes affiliated with Wernicke Encephalopathy

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Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:004511110.1GFAP, INA
2glial cell projectionGO:00973869.9GFAP, GLUL
3cytoplasmic ribonucleoprotein granuleGO:00364649.8INA, MAPT
4cell projectionGO:00429959.6GFAP, GLUL, SLC1A3
5cell bodyGO:00442979.2GFAP, GLUL, MAPT
6myelin sheathGO:00432098.5GFAP, GLUL, INA, TKT

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1amino acid transmembrane transportGO:000333310.4SLC1A2, SLC1A3
2D-aspartate importGO:007077910.4SLC1A2, SLC1A3
3glutamate secretionGO:001404710.4SLC1A2, SLC1A3
4L-glutamate importGO:005193810.4SLC1A2, SLC1A3
5L-glutamate transmembrane transportGO:008971110.4SLC1A2, SLC1A3
6L-glutamate transportGO:001581310.4SLC1A2, SLC1A3
7gamma-aminobutyric acid biosynthetic processGO:000944910.3GAD1, SLC1A3
8response to light stimulusGO:000941610.2SLC1A2, SLC1A3
9glutamate metabolic processGO:000653610.2GLUL, SLC1A3
10neurotransmitter uptakeGO:000150410.2GLUL, SLC1A3
11glutamate catabolic processGO:000653810.0GAD1, GLUL
12chemical synaptic transmissionGO:00072689.9GAD1, SLC1A2, SLC1A3
13response to drugGO:00424939.7GAD1, SLC1A2, SLC1A3
14response to woundingGO:00096119.2GFAP, SLC1A2, SLC1A3

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1amino acid transmembrane transporter activityGO:001517110.3SLC1A2, SLC1A3
2high-affinity glutamate transmembrane transporter activityGO:000531410.3SLC1A2, SLC1A3
3L-glutamate transmembrane transporter activityGO:000531310.3SLC1A2, SLC1A3
4glutamate decarboxylase activityGO:00043519.9GAD1, GLUL
5glutamate bindingGO:00165959.5GAD1, GLUL, SLC1A3
6structural constituent of cytoskeletonGO:00052008.7GFAP, INA, MAPT

Sources for Wernicke Encephalopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet