MCID: WRN002
MIFTS: 50

Wernicke-Korsakoff Syndrome malady

Summaries for Wernicke-Korsakoff Syndrome

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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NINDS:44 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. Symptoms include mental confusion, vision impairment, stupor, coma, hypothermia, hypotension, and ataxia. -a memory disorder-also results from a deficiency of thiamine, and is associated with alcoholism. The heart, vascular, and nervous system are involved. Symptoms include amnesia, confabulation, attention deficit, disorientation, and vision impairment. The main features of Korsakoff's amnesic syndrome are the impairments in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's may appear to be two different disorders, they are generally considered to be different stages of the same disorder, which is called . Wernicke's encephalopathy represents the "acute" phase of the disorder, and Korsakoff's amnesic syndrome represents the "chronic" phase.

MalaCards: Wernicke-Korsakoff Syndrome, also known as alcohol induced encephalopathy, is related to wernicke encephalopathy and beriberi. An important gene associated with Wernicke-Korsakoff Syndrome is SLC19A2 (solute carrier family 19 (thiamine transporter), member 2), and among its related pathways are Vitamin digestion and absorption and Pentose phosphate pathway (hexose monophosphate shunt). The drugs chlordiazepoxide and citalopram and the compounds [3h]thiamine and rivastigmine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related mouse phenotypes are growth/size and behavior/neurological.

NIH Rare Diseases:43 Wernicke-korsakoff syndrome is a brain disorder due to thiamine deficiency that has been associated with both wernicke's encephalopathy and korsakoff syndrome. wernicke's encephalopathy can result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. korsakoff's amnesic syndrome is a memory disorder that is associated with alcoholism and involvement of the heart, vascular, and nervous system. although these conditions may appear to be two different disorders, they are generally considered to be different stages of wernicke-korsakoff syndrome. wernicke's encephalopathy represents the "acute" phase and korsakoff's amnesic syndrome represents the "chronic" phase. last updated: 10/20/2011

Wikipedia:64 Wernicke–Korsakoff syndrome (WKS)—also called wet brain, Korsakoff\'s psychosis, and alcoholic... more...

Description from OMIM:47 277730

Aliases & Classifications for Wernicke-Korsakoff Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 61UMLS, 45Novoseek, 40NCIt, 57SNOMED-CT, 47OMIM, 35MeSH
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Aliases & Descriptions:

wernicke-korsakoff syndrome 8 43 44 10 61
alcohol induced encephalopathy 43 61
korsakoff's amnesic syndrome 43 44
transketolase defect 43 61
korsakoff syndrome 8 45
alcoholic intoxication, chronic 61
wernicke-korsakov syndrome 8
wernicke's encephalopathy 43
korsakoff's psychosis 8
korsakov's psychosis 8
korsakoff's syndrome 8
korsakov psychosis 8


External Ids:

Disease Ontology8 DOID:10915
OMIM47 277730
MeSH35 D020915

Related Diseases for Wernicke-Korsakoff Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Wernicke-Korsakoff Syndrome:



Diseases related to wernicke-korsakoff syndrome

Clinical Features for Wernicke-Korsakoff Syndrome

Sources:
47OMIM
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Clinical features from OMIM:

277730

Drugs & Therapeutics for Wernicke-Korsakoff Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Wernicke-Korsakoff Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Wernicke-Korsakoff Syndrome

Anatomical Context for Wernicke-Korsakoff Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Wernicke-Korsakoff Syndrome:

33
Liver, Brain, Heart, T cells, B cells

Animal Models for Wernicke-Korsakoff Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Wernicke-Korsakoff Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.8FOXB1, DLST, TKTL1, TKT, SLC19A3, ACHE
2MP:00053867.6ACHE, APOE, FOXB1, DLST, TKT, SLC19A3

Publications for Wernicke-Korsakoff Syndrome

Sources:
51PubMed
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Articles related to Wernicke-Korsakoff Syndrome:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome. (22192411)
2012
2
Evolution of Wernicke-Korsakoff syndrome in self-neglecting alcoholics: preliminary results of relation with Wernicke-delirium and diabetes mellitus. (22332852)
2012
3
Wernicke-Korsakoff-syndrome: under-recognized and under-treated. (23157990)
2012
4
Teaching neuroimages: bilateral anterior thalami and fornix macrohemorrhage in Wernicke-Korsakoff syndrome. (22123785)
2011
5
Stage-dependent alterations of progenitor cell proliferation and neurogenesis in an animal model of Wernicke-Korsakoff syndrome. (21440532)
2011
6
Wernicke-Korsakoff syndrome in the course of thyrotoxicosis - a case report. (21528481)
2011
7
Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. (20364001)
2010
8
Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. (18379741)
2008
9
Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency. (18584388)
2008
10
Correlation between phosphorylation level of a hippocampal 86kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome. (17395279)
2007
11
Acetylcholinesterase inhibitors for the treatment of Wernicke-Korsakoff syndrome--three further cases show response to donepezil. (15596427)
2005
12
Eating avoidance disorder and Wernicke-Korsakoff syndrome following gastric bypass: an under-diagnosed association. (16197798)
2005
13
Persistence of disturbed thalamic glucose metabolism in a case of Wernicke-Korsakoff syndrome. (14561428)
2003
14
Memory loss and ataxia after hyperemesis gravidarum: a case of Wernicke-Korsakoff syndrome. (12039101)
2002
15
No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (11445257)
2001
16
Australian experience with the Wernicke-Korsakoff syndrome. (10946433)
2000
17
Wernicke-Korsakoff syndrome and the use of brain imaging. (11304072)
2000
18
Wernicke-Korsakoff amnestic syndrome secondary to malnutrition in a patient with schizoaffective disorder. (9845417)
1998
19
Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference? (9640303)
1998
20
A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. (9194907)
1997
21
The nucleus basalis (Ch4) in the alcoholic Wernicke-Korsakoff syndrome: reduced cell number in both amnesic and non-amnesic patients. (9328247)
1997
22
"Grievous bodily harm:" gamma hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome. (8614515)
1996
23
Chronic alcoholics without Wernicke-Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus. (8651464)
1996
24
Preventing the Wernicke-Korsakoff syndrome in Australia: cost-effectiveness of thiamin-supplementation alternatives. (8799094)
1996
25
Chronic alcoholism in the absence of Wernicke-Korsakoff syndrome and cirrhosis does not result in the loss of serotonergic neurons from the median raphe nucleus. (8869942)
1996
26
Wernicke-Korsakoff syndrome in a liver transplant recipient. (8942207)
1996
27
Neuropathological correlates of memory dysfunction in the Wernicke-Korsakoff syndrome. (8974343)
1994
28
An enzymatic and immunochemical analysis of transketolase in fibroblasts from Wernicke-Korsakoff syndrome. (8445392)
1993
29
Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. (8279670)
1993
30
Wernicke-Korsakoff syndrome. (1821238)
1991
31
Wernicke-Korsakoff syndrome of nonalcoholic origin. (1901211)
1991
32
MR in the diagnosis of Wernicke-Korsakoff syndrome. (2122686)
1990
33
Prevention of the Wernicke-Korsakoff syndrome in Australia: a cost-benefit analysis. (2497310)
1989
34
The prevalence of the Wernicke-Korsakoff syndrome in Sydney, Australia: a prospective necropsy study. (2784828)
1989
35
Three-dimensional mapping of local cerebral perfusion in alcoholic encephalopathy with and without Wernicke-Korsakoff syndrome. (3805163)
1987
36
A comparison of brainstem auditory evoked responses evoked by rarefaction and condensation stimulation in control subjects and in patients with Wernicke-Korsakoff syndrome and multiple sclerosis. (3734836)
1986
37
Current progress toward the prevention of the Wernicke-Korsakoff syndrome. (3814251)
1986
38
The continuity hypothesis: the relationship of long-term alcoholism to the Wernicke-Korsakoff syndrome. (3883444)
1985
39
Wernicke-Korsakoff syndrome. (6697048)
1984
40
Wernicke-Korsakoff syndrome after subtotal gastrectomy. (6618863)
1983
41
The Wernicke-Korsakoff syndrome: a review of psychological, neuropathological and etiological factors. (6806017)
1981
42
The Wernicke-Korsakoff syndrome. (7424767)
1980
43
Hypothermia and coma in the Wernicke-Korsakoff syndrome. (7207347)
1980
44
Prevention of the Wernicke-Korsakoff syndrome: an updated cost-benefit analysis. (104174)
1979
45
Genetic factors in Wernicke-Korsakoff syndrome. (391073)
1979
46
Wernicke-Korsakoff Syndrome: a case approach. (213580)
1978
47
Prevention of the Wernicke-Korsakoff syndrome: a cost-benefit analysis. (96343)
1978
48
Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. (927453)
1977
49
The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. (5162155)
1971
50
A psychological study of the Wernicke-Korsakoff syndrome. Results of Wechsler-Bellevue intelligence scale and Wechsler memory scale testing at different stages in the disease. (13842087)
1959

Genetic Variations for Wernicke-Korsakoff Syndrome

Expression for genes affiliated with Wernicke-Korsakoff Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wernicke-Korsakoff Syndrome

Search GEO for disease gene expression data for Wernicke-Korsakoff Syndrome.

Pathways for genes affiliated with Wernicke-Korsakoff Syndrome

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Wernicke-Korsakoff Syndrome

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1[3h]thiamine2910.2SLC19A3, SLC19A2
2rivastigmine45 1111.1APOE, ACHE
3metrifonate4510.0ACHE, APOE
4cdp choline4510.0ACHE, APOE
5thiamin diphosphate4510.0TPK1, TKT
6tacrine45 1110.9ACHE, APOE
7donepezil45 11 2411.8ACHE, APOE
8(S)-Succinyldihydrolipoamide249.6OGDH, DLST
9thiamine triphosphate45 2410.6THTPA, TPK1
10galantamine45 50 1111.6APOE, ACHE
11thiamine monophosphate45 2410.6OGDH, TKT, TPK1
12glutaryl-coa45 2410.5OGDH, DLST
13dihydrolipoamide45 2410.4OGDH, DLST
14magnesium45 11 2411.0TPK1, TKTL2, TKT, TKTL1
15alpha-ketoglutarate458.9TPK1, TKT, DLST, OGDH
16pyruvate458.9OGDH, DLST, TKT, TPK1
17thiamine pyrophosphate45 248.9OGDH, TKTL1, TKT, TKTL2, THTPA, TPK1
18thiamine45 2 11 2410.9TPK1, OGDH, APOE, TKT, THTPA, SLC19A3

GO Terms for genes affiliated with Wernicke-Korsakoff Syndrome

Sources:
16Gene Ontology
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Cellular components related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxoglutarate dehydrogenase complexGO:0452529.3DLST, OGDH

Biological processes related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:0072719.6ACHE, APOE
2lysine catabolic processGO:0065549.3DLST, OGDH
3thalamus developmentGO:0217949.3FOXB1, OGDH
4tricarboxylic acid cycleGO:0060999.3DLST, OGDH
5thiamine metabolic processGO:0067729.2TKTL1, THTPA, TPK1
6thiamine-containing compound metabolic processGO:0427239.0TPK1, SLC19A2, SLC19A3, THTPA
7water-soluble vitamin metabolic processGO:0067679.0THTPA, SLC19A3, SLC19A2, TPK1
8vitamin metabolic processGO:0067668.9TPK1, SLC19A2, SLC19A3, THTPA
9generation of precursor metabolites and energyGO:0060918.6OGDH, DLST, THTPA
10small molecule metabolic processGO:0442816.9OGDH, APOE, DLST, TKT, THTPA, SLC19A3

Molecular functions related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thiamine uptake transmembrane transporter activityGO:01540310.0SLC19A2, SLC19A3
2beta-amyloid bindingGO:0015409.9ACHE, APOE
3reduced folate carrier activityGO:0085189.9SLC19A3, SLC19A2
4folic acid bindingGO:0055429.7SLC19A2, SLC19A3
5transketolase activityGO:0048029.4TKTL2, TKT, TKTL1

Products for genes affiliated with Wernicke-Korsakoff Syndrome

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Sources for Wernicke-Korsakoff Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet