MCID: WRN002
MIFTS: 46

Wernicke-Korsakoff Syndrome malady

Rare diseases category

Aliases & Classifications for Wernicke-Korsakoff Syndrome

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Wernicke-Korsakoff Syndrome, Aliases & Descriptions:

Name: Wernicke-Korsakoff Syndrome 9 41 42 11 60
Alcohol Induced Encephalopathy 41 60
Korsakoff's Amnesic Syndrome 41 42
Transketolase Defect 41 60
Korsakoff Syndrome 9 43
 
Wernicke's Encephalopathy 41
Korsakoff's Psychosis 9
Korsakov's Psychosis 9
Korsakoff's Syndrome 9
Korsakov Psychosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:10915
MeSH33 D020915

Summaries for Wernicke-Korsakoff Syndrome

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NINDS:42 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. Symptoms include mental confusion, vision impairment, stupor, coma, hypothermia, hypotension, and ataxia. -a memory disorder-also results from a deficiency of thiamine, and is associated with alcoholism. The heart, vascular, and nervous system are involved. Symptoms include amnesia, confabulation, attention deficit, disorientation, and vision impairment. The main features of Korsakoff's amnesic syndrome are the impairments in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's may appear to be two different disorders, they are generally considered to be different stages of the same disorder, which is called . Wernicke's encephalopathy represents the "acute" phase of the disorder, and Korsakoff's amnesic syndrome represents the "chronic" phase.

MalaCards based summary: Wernicke-Korsakoff Syndrome, also known as alcohol induced encephalopathy, is related to wernicke encephalopathy and cerebritis, and has symptoms including autosomal recessive inheritance, ptosis and ophthalmoplegia. An important gene associated with Wernicke-Korsakoff Syndrome is TKT (transketolase), and among its related pathways are Pentose Phosphate Pathway and Lysine degradation. The compounds thiamin diphosphate and rivastigmine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are other and nervous system.

NIH Rare Diseases:41 Wernicke-korsakoff syndrome is a brain disorder due to thiamine deficiency that has been associated with both wernicke's encephalopathy and korsakoff syndrome. wernicke's encephalopathy can result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. korsakoff's amnesic syndrome is a memory disorder that is associated with alcoholism and involvement of the heart, vascular, and nervous system. although these conditions may appear to be two different disorders, they are generally considered to be different stages of wernicke-korsakoff syndrome. wernicke's encephalopathy represents the "acute" phase and korsakoff's amnesic syndrome represents the "chronic" phase. last updated: 10/20/2011

Wikipedia:63 Wernicke?Korsakoff syndrome (WKS), also called wet brain, Korsakoff\'s psychosis, and alcoholic... more...

Related Diseases for Wernicke-Korsakoff Syndrome

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Graphical network of the top 20 diseases related to Wernicke-Korsakoff Syndrome:



Diseases related to wernicke-korsakoff syndrome

Symptoms for Wernicke-Korsakoff Syndrome

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HPO human phenotypes related to Wernicke-Korsakoff Syndrome:

(show all 10)
id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 ptosis HP:0000508
3 ophthalmoplegia HP:0000602
4 horizontal nystagmus HP:0000666
5 psychosis HP:0000709
6 ataxia HP:0001251
7 coma HP:0001259
8 polyneuropathy HP:0001271
9 confusion HP:0001289
10 memory impairment HP:0002354

Drugs & Therapeutics for Wernicke-Korsakoff Syndrome

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Drug clinical trials:

Search ClinicalTrials for Wernicke-Korsakoff Syndrome

Search NIH Clinical Center for Wernicke-Korsakoff Syndrome

Genetic Tests for Wernicke-Korsakoff Syndrome

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Anatomical Context for Wernicke-Korsakoff Syndrome

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MalaCards organs/tissues related to Wernicke-Korsakoff Syndrome:

31
Brain, Heart, Liver, Testes, T cells

Animal Models for Wernicke-Korsakoff Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Wernicke-Korsakoff Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.8DLST, FOXB1, APOE
2MP:00036318.3TKT, DLST, ACHE, FOXB1, APOE
3MP:00053868.0APOE, FOXB1, ACHE, DLST, TKT
4MP:00053787.8TKT, APOE, FOXB1, ACHE, DLST, TKTL1

Publications for Wernicke-Korsakoff Syndrome

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Articles related to Wernicke-Korsakoff Syndrome:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review. (25589780)
2015
2
Spatial cognitive deficits in an animal model of Wernicke-Korsakoff syndrome are related to changes in thalamic VDAC protein concentrations. (25766938)
2015
3
Neural Correlate of Anterograde Amnesia in Wernicke-Korsakoff Syndrome. (25148770)
2014
4
Wernicke-korsakoff syndrome in primary peritoneal cancer. (24474922)
2013
5
Biomarkers of delirium as a clue to diagnosis and pathogenesis of Wernicke-Korsakoff syndrome. (23790077)
2013
6
Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome. (22192411)
2012
7
Teaching neuroimages: bilateral anterior thalami and fornix macrohemorrhage in Wernicke-Korsakoff syndrome. (22123785)
2011
8
Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study. (19960210)
2010
9
Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. (20364001)
2010
10
Neuroimaging of the Wernicke-Korsakoff syndrome. (19066199)
2009
11
Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. (18379741)
2008
12
Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency. (18584388)
2008
13
A clinical and radiographic variant of Wernicke-Korsakoff syndrome in a nonalcoholic patient. (17159109)
2006
14
Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome. (15922063)
2005
15
Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). (16015585)
2005
16
Increased cerebellar PET glucose metabolism corresponds to ataxia in Wernicke-Korsakoff syndrome. (14998834)
2004
17
Wernicke-Korsakoff syndrome and galantamine. (15232056)
2004
18
Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse. (14974055)
2004
19
Wernicke-Korsakoff syndrome and alcohol-induced persistent dementia. (15555036)
2004
20
A placebo-controlled study of memantine (Ebixa) in dementia of Wernicke-Korsakoff syndrome. (12858653)
2003
21
Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers. (12454526)
2002
22
Memory loss and ataxia after hyperemesis gravidarum: a case of Wernicke-Korsakoff syndrome. (12039101)
2002
23
No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (11445257)
2001
24
Wernicke-Korsakoff syndrome in Sydney hospitals after 6 years of thiamin enrichment of bread. (10933408)
1998
25
Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference? (9640303)
1998
26
A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. (9194907)
1997
27
"Grievous bodily harm:" gamma hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome. (8614515)
1996
28
Severe global amnesia presenting as Wernicke-Korsakoff syndrome but resulting from atypical lesions. (8685298)
1996
29
Chronic alcoholics without Wernicke-Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus. (8651464)
1996
30
Preventing the Wernicke-Korsakoff syndrome in Australia: cost-effectiveness of thiamin-supplementation alternatives. (8799094)
1996
31
An international perspective on the prevalence of the Wernicke-Korsakoff syndrome. (7596325)
1995
32
Neuropathological correlates of memory dysfunction in the Wernicke-Korsakoff syndrome. (8974343)
1994
33
Wernicke-Korsakoff syndrome following attempted hanging. (8235215)
1993
34
Wernicke-Korsakoff syndrome. (1821238)
1991
35
Wernicke-Korsakoff syndrome complicating T-cell lymphoma: unusual or unrecognized? (1990464)
1991
36
The changing face of the Wernicke-Korsakoff syndrome. (16840155)
1990
37
MR in the diagnosis of Wernicke-Korsakoff syndrome. (2122686)
1990
38
Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. (2675860)
1989
39
A comparison of brainstem auditory evoked responses evoked by rarefaction and condensation stimulation in control subjects and in patients with Wernicke-Korsakoff syndrome and multiple sclerosis. (3734836)
1986
40
Abstinence improves cerebral perfusion and brain volume in alcoholic neurotoxicity without Wernicke-Korsakoff syndrome. (3944220)
1986
41
The Wernicke-Korsakoff syndrome in Queensland, Australia: antecedents and prevention. (4052158)
1985
42
Some observations on the Wernicke Korsakoff syndrome in Australia. (3856451)
1985
43
Wernicke-Korsakoff syndrome. (6697048)
1984
44
Is there a genetic component to the pathogenesis of the Wernicke-Korsakoff syndrome? (6508876)
1984
45
Computed tomographic findings in Wernicke-Korsakoff syndrome. (6703950)
1984
46
Erythrocyte transketolase activity in the Wernicke-Korsakoff syndrome. (7306754)
1981
47
The Wernicke-Korsakoff syndrome. (7424767)
1980
48
Prevention of the Wernicke-Korsakoff syndrome: an updated cost-benefit analysis. (104174)
1979
49
Long-term therapy for the mental disturbances of Wernicke-Korsakoff syndrome. (845586)
1977
50
Cerebral blood flow and metabolism in the Wernicke-Korsakoff syndrome. (6025486)
1967

Variations for Wernicke-Korsakoff Syndrome

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Expression for genes affiliated with Wernicke-Korsakoff Syndrome

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Search GEO for disease gene expression data for Wernicke-Korsakoff Syndrome.

Pathways for genes affiliated with Wernicke-Korsakoff Syndrome

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Pathways related to Wernicke-Korsakoff Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)36
pentose phosphate pathway36
PRPP biosynthesis36
9.7TKTL1, TKT
29.3DLST, OGDH
3
Show member pathways
TCA cycle36
pyruvate decarboxylation to acetyl CoA36
NAD phosphorylation and dephosphorylation36
TCA Cycle36
conversion of glucose to acetyl CoA and entry into the TCA cycle36
9.3DLST, OGDH
49.3THTPA, TPK1
5
Show member pathways
flavin biosynthesis IV (mammalian)36
molybdenum cofactor biosynthesis36
coenzyme A biosynthesis36
thiamin salvage III36
alanine biosynthesis III36
thio-molybdenum cofactor biosynthesis36
biotin-carboxyl carrier protein assembly36
9.3THTPA, TPK1
69.1TKT, DLST, APOE
7
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
8.6DLST, OGDH, TKTL1, TKT
8
Show member pathways
6.6TKTL1, TKT, OGDH, DLST, ACHE, TPK1

Compounds for genes affiliated with Wernicke-Korsakoff Syndrome

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Compounds related to Wernicke-Korsakoff Syndrome according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1thiamin diphosphate4310.2TPK1, TKT
2rivastigmine43 1211.1APOE, ACHE
3Xylulose 5-phosphate2410.1TKTL1, TKT
4Sedoheptulose2410.1TKTL1, TKT
5metrifonate4310.1APOE, ACHE
6D-Sedoheptulose 7-phosphate2410.1TKTL1, TKT
7cdp choline4310.0APOE, ACHE
8D-Erythrose 4-phosphate2410.0TKT, TKTL1
9tacrine43 1211.0APOE, ACHE
10D-Ribose 5-phosphate2410.0TKT, TKTL1
11D-Ribulose 5-phosphate2410.0TKT, TKTL1
12donepezil43 49 24 1213.0APOE, ACHE
13galantamine43 49 1211.9APOE, ACHE
14Beta-D-Fructose 6-phosphate249.9TKT, TKTL1
15parathion43 2410.9TKT, ACHE
16tetrodotoxin43 59 2811.7ACHE, APOE
17(S)-Succinyldihydrolipoamide249.7DLST, OGDH
18S-Glutaryldihydrolipoamide249.7OGDH, DLST
19glutaryl-coa43 2410.7DLST, OGDH
20thiamine triphosphate43 2410.7THTPA, TPK1
21thiamine monophosphate43 2410.7TPK1, OGDH, TKT
22dihydrolipoamide43 2410.6OGDH, DLST
23glucose 6-phosphate43 2410.6TKT, OGDH
24Succinyl-CoA249.6DLST, OGDH
25nmda43 2810.6APOE, ACHE, TKT
26glutamine439.3APOE, OGDH, TKT
274-hydroxynonenal43 2410.2OGDH, APOE
28creatinine439.1APOE, OGDH, TKT
29glutamate439.1TKT, OGDH, ACHE, APOE
30alpha-ketoglutarate439.0TKT, OGDH, DLST, TPK1
31pyruvate439.0TPK1, DLST, OGDH, TKT
32atp43 289.6TKT, OGDH, TPK1, THTPA
33thiamine43 2 24 1211.4THTPA, APOE, TPK1, OGDH, TKT
34thiamine pyrophosphate43 249.4TKT, TKTL1, OGDH, TPK1, THTPA

GO Terms for genes affiliated with Wernicke-Korsakoff Syndrome

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Cellular components related to Wernicke-Korsakoff Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxoglutarate dehydrogenase complexGO:00452529.3OGDH, DLST

Biological processes related to Wernicke-Korsakoff Syndrome according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00072719.7APOE, ACHE
2thalamus developmentGO:00217949.5OGDH, FOXB1
3lysine catabolic processGO:00065549.4OGDH, DLST
4thiamine-containing compound metabolic processGO:00427239.4THTPA, TPK1
5vitamin metabolic processGO:00067669.3TPK1, THTPA
6tricarboxylic acid cycleGO:00060999.2OGDH, DLST
7thiamine metabolic processGO:00067729.0TKTL1, TPK1, THTPA
8water-soluble vitamin metabolic processGO:00067679.0TPK1, THTPA
9generation of precursor metabolites and energyGO:00060918.7OGDH, DLST, THTPA
10small molecule metabolic processGO:00442817.3THTPA, APOE, TPK1, ACHE, DLST, OGDH

Molecular functions related to Wernicke-Korsakoff Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid bindingGO:00015409.7ACHE, APOE
2transketolase activityGO:00048029.4TKT, TKTL1

Products for genes affiliated with Wernicke-Korsakoff Syndrome

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Sources for Wernicke-Korsakoff Syndrome

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