MCID: WRN002
MIFTS: 54

Wernicke-Korsakoff Syndrome malady

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Summaries for Wernicke-Korsakoff Syndrome

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43NIH Rare Diseases, 44NINDS, 65Wikipedia, 47OMIM, 33MalaCards
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NINDS:44 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. Symptoms include mental confusion, vision impairment, stupor, coma, hypothermia, hypotension, and ataxia. -a memory disorder-also results from a deficiency of thiamine, and is associated with alcoholism. The heart, vascular, and nervous system are involved. Symptoms include amnesia, confabulation, attention deficit, disorientation, and vision impairment. The main features of Korsakoff's amnesic syndrome are the impairments in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's may appear to be two different disorders, they are generally considered to be different stages of the same disorder, which is called . Wernicke's encephalopathy represents the "acute" phase of the disorder, and Korsakoff's amnesic syndrome represents the "chronic" phase.

MalaCards: Wernicke-Korsakoff Syndrome, also known as alcohol induced encephalopathy, is related to alzheimer's disease and cerebritis. An important gene associated with Wernicke-Korsakoff Syndrome is TKT (transketolase), and among its related pathways are Pentose Phosphate Pathway and Citric acid cycle (TCA cycle). The drugs chlordiazepoxide and citalopram and the compounds thiamin diphosphate and rivastigmine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are other and nervous system.

NIH Rare Diseases:43 Wernicke-korsakoff syndrome is a brain disorder due to thiamine deficiency that has been associated with both wernicke's encephalopathy and korsakoff syndrome. wernicke's encephalopathy can result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. korsakoff's amnesic syndrome is a memory disorder that is associated with alcoholism and involvement of the heart, vascular, and nervous system. although these conditions may appear to be two different disorders, they are generally considered to be different stages of wernicke-korsakoff syndrome. wernicke's encephalopathy represents the "acute" phase and korsakoff's amnesic syndrome represents the "chronic" phase. last updated: 10/20/2011

Wikipedia:65 Wernicke?Korsakoff syndrome (WKS)?also called wet brain, Korsakoff\'s psychosis, and alcoholic... more...

Description from OMIM:47 277730

Aliases & Classifications for Wernicke-Korsakoff Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 62UMLS, 45Novoseek, 58SNOMED-CT, 40NCIt, 35MeSH, 47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

wernicke-korsakoff syndrome 8 43 44 10 62
alcohol induced encephalopathy 43 62
korsakoff's amnesic syndrome 43 44
transketolase defect 43 62
korsakoff syndrome 8 45
alcoholic intoxication, chronic 62
wernicke-korsakov syndrome 8
wernicke's encephalopathy 43
korsakoff's psychosis 8
korsakov's psychosis 8
korsakoff's syndrome 8
korsakov psychosis 8


External Ids:

Disease Ontology8 DOID:10915
MeSH35 D020915
OMIM47 277730

Related Diseases for Wernicke-Korsakoff Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Wernicke-Korsakoff Syndrome:



Diseases related to wernicke-korsakoff syndrome

Symptoms for Wernicke-Korsakoff Syndrome

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47OMIM
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Clinical features from OMIM:

277730

Drugs & Therapeutics for Wernicke-Korsakoff Syndrome

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Wernicke-Korsakoff Syndrome

Search NIH Clinical Center for Wernicke-Korsakoff Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Wernicke-Korsakoff Syndrome

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Anatomical Context for Wernicke-Korsakoff Syndrome

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33MalaCards
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MalaCards organs/tissues related to Wernicke-Korsakoff Syndrome:

33
Brain, Heart, Liver, Testes, T cells

Animal Models for Wernicke-Korsakoff Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Wernicke-Korsakoff Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.8FOXB1, DLST, APOE
2MP:00036318.3ACHE, DLST, APOE, TKT, FOXB1
3MP:00053868.0ACHE, TKT, DLST, FOXB1, APOE
4MP:00053787.8TKT, TKTL1, DLST, ACHE, FOXB1, APOE

Publications for Wernicke-Korsakoff Syndrome

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52PubMed
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Articles related to Wernicke-Korsakoff Syndrome:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Biomarkers of delirium as a clue to diagnosis and pathogenesis of Wernicke-Korsakoff syndrome. (23790077)
2013
2
Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome. (22192411)
2012
3
Evolution of Wernicke-Korsakoff syndrome in self-neglecting alcoholics: preliminary results of relation with Wernicke-delirium and diabetes mellitus. (22332852)
2012
4
Teaching neuroimages: bilateral anterior thalami and fornix macrohemorrhage in Wernicke-Korsakoff syndrome. (22123785)
2011
5
Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study. (19960210)
2010
6
Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. (20364001)
2010
7
Neuroimaging of the Wernicke-Korsakoff syndrome. (19066199)
2009
8
Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. (18379741)
2008
9
Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency. (18584388)
2008
10
A clinical and radiographic variant of Wernicke-Korsakoff syndrome in a nonalcoholic patient. (17159109)
2006
11
Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome. (15922063)
2005
12
Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). (16015585)
2005
13
Increased cerebellar PET glucose metabolism corresponds to ataxia in Wernicke-Korsakoff syndrome. (14998834)
2004
14
Wernicke-Korsakoff syndrome and galantamine. (15232056)
2004
15
Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse. (14974055)
2004
16
Wernicke-Korsakoff syndrome and alcohol-induced persistent dementia. (15555036)
2004
17
A placebo-controlled study of memantine (Ebixa) in dementia of Wernicke-Korsakoff syndrome. (12858653)
2003
18
Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers. (12454526)
2002
19
Memory loss and ataxia after hyperemesis gravidarum: a case of Wernicke-Korsakoff syndrome. (12039101)
2002
20
No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (11445257)
2001
21
Wernicke-Korsakoff syndrome in Sydney hospitals after 6 years of thiamin enrichment of bread. (10933408)
1998
22
Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference? (9640303)
1998
23
A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. (9194907)
1997
24
"Grievous bodily harm:" gamma hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome. (8614515)
1996
25
Severe global amnesia presenting as Wernicke-Korsakoff syndrome but resulting from atypical lesions. (8685298)
1996
26
Chronic alcoholics without Wernicke-Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus. (8651464)
1996
27
Preventing the Wernicke-Korsakoff syndrome in Australia: cost-effectiveness of thiamin-supplementation alternatives. (8799094)
1996
28
An international perspective on the prevalence of the Wernicke-Korsakoff syndrome. (7596325)
1995
29
Molecular genetics of transketolase in the pathogenesis of the Wernicke-Korsakoff syndrome. (7596328)
1995
30
Neuropathological correlates of memory dysfunction in the Wernicke-Korsakoff syndrome. (8974343)
1994
31
Wernicke-Korsakoff syndrome following attempted hanging. (8235215)
1993
32
Wernicke-Korsakoff syndrome. (1821238)
1991
33
Wernicke-Korsakoff syndrome complicating T-cell lymphoma: unusual or unrecognized? (1990464)
1991
34
The changing face of the Wernicke-Korsakoff syndrome. (16840155)
1990
35
MR in the diagnosis of Wernicke-Korsakoff syndrome. (2122686)
1990
36
Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. (2675860)
1989
37
A comparison of brainstem auditory evoked responses evoked by rarefaction and condensation stimulation in control subjects and in patients with Wernicke-Korsakoff syndrome and multiple sclerosis. (3734836)
1986
38
Abstinence improves cerebral perfusion and brain volume in alcoholic neurotoxicity without Wernicke-Korsakoff syndrome. (3944220)
1986
39
Current progress toward the prevention of the Wernicke-Korsakoff syndrome. (3814251)
1986
40
The Wernicke-Korsakoff syndrome in Queensland, Australia: antecedents and prevention. (4052158)
1985
41
Some observations on the Wernicke Korsakoff syndrome in Australia. (3856451)
1985
42
Cerebral atrophy and hypoperfusion improve during treatment of Wernicke-Korsakoff syndrome. (4030916)
1985
43
Wernicke-Korsakoff syndrome. (6697048)
1984
44
Is there a genetic component to the pathogenesis of the Wernicke-Korsakoff syndrome? (6508876)
1984
45
Computed tomographic findings in Wernicke-Korsakoff syndrome. (6703950)
1984
46
Erythrocyte transketolase activity in the Wernicke-Korsakoff syndrome. (7306754)
1981
47
The Wernicke-Korsakoff syndrome. (7424767)
1980
48
Long-term therapy for the mental disturbances of Wernicke-Korsakoff syndrome. (845586)
1977
49
The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. (5162155)
1971
50
Cerebral blood flow and metabolism in the Wernicke-Korsakoff syndrome. (6025486)
1967

Variations for Wernicke-Korsakoff Syndrome

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Expression for genes affiliated with Wernicke-Korsakoff Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wernicke-Korsakoff Syndrome

Search GEO for disease gene expression data for Wernicke-Korsakoff Syndrome.

Pathways for genes affiliated with Wernicke-Korsakoff Syndrome

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 5Cell Signaling Technology, 51PharmGKB
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Pathways related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)38
pentose phosphate pathway38
PRPP biosynthesis38
9.7TKT, TKTL1
2
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
9.3OGDH, DLST
39.3DLST, OGDH
49.3THTPA, TPK1
5
Show member pathways
flavin biosynthesis IV (mammalian)38
molybdenum cofactor biosynthesis38
coenzyme A biosynthesis38
thiamin salvage III38
alanine biosynthesis III38
thio-molybdenum cofactor biosynthesis38
biotin-carboxyl carrier protein assembly38
9.3TPK1, THTPA
69.1TKT, DLST, APOE
7
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
8.6TKT, TKTL1, OGDH, DLST
8
Show member pathways
6.6TKT, THTPA, APOE, TPK1, ACHE, DLST

Compounds for genes affiliated with Wernicke-Korsakoff Syndrome

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1thiamin diphosphate4510.2TPK1, TKT
2rivastigmine45 1111.1APOE, ACHE
3Xylulose 5-phosphate2410.1TKTL1, TKT
4Sedoheptulose2410.1TKTL1, TKT
5metrifonate4510.1APOE, ACHE
6D-Sedoheptulose 7-phosphate2410.1TKTL1, TKT
7cdp choline4510.0APOE, ACHE
8D-Erythrose 4-phosphate2410.0TKT, TKTL1
9tacrine45 1111.0APOE, ACHE
10D-Ribose 5-phosphate2410.0TKT, TKTL1
11D-Ribulose 5-phosphate2410.0TKT, TKTL1
12donepezil45 51 24 1113.0APOE, ACHE
13galantamine45 51 1111.9APOE, ACHE
14Beta-D-Fructose 6-phosphate249.9TKT, TKTL1
15parathion45 2410.9TKT, ACHE
16tetrodotoxin45 61 2911.7ACHE, APOE
17(S)-Succinyldihydrolipoamide249.7DLST, OGDH
18S-Glutaryldihydrolipoamide249.7OGDH, DLST
19glutaryl-coa45 2410.7DLST, OGDH
20thiamine triphosphate45 2410.7THTPA, TPK1
21thiamine monophosphate45 2410.7TPK1, OGDH, TKT
22dihydrolipoamide45 2410.6OGDH, DLST
23glucose 6-phosphate45 2410.6TKT, OGDH
24Succinyl-CoA249.6DLST, OGDH
25nmda45 2910.6APOE, ACHE, TKT
26glutamine459.3APOE, OGDH, TKT
274-hydroxynonenal45 2410.2OGDH, APOE
28creatinine459.1APOE, OGDH, TKT
29glutamate459.1TKT, OGDH, ACHE, APOE
30alpha-ketoglutarate459.0TKT, OGDH, DLST, TPK1
31pyruvate459.0TPK1, DLST, OGDH, TKT
32atp45 299.6TKT, OGDH, TPK1, THTPA
33thiamine45 3 24 1111.4THTPA, APOE, TPK1, OGDH, TKT
34thiamine pyrophosphate45 249.4TKT, TKTL1, OGDH, TPK1, THTPA

GO Terms for genes affiliated with Wernicke-Korsakoff Syndrome

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16Gene Ontology
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Cellular components related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxoglutarate dehydrogenase complexGO:0452529.3OGDH, DLST

Biological processes related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:0072719.7APOE, ACHE
2thalamus developmentGO:0217949.5OGDH, FOXB1
3lysine catabolic processGO:0065549.4OGDH, DLST
4thiamine-containing compound metabolic processGO:0427239.4THTPA, TPK1
5vitamin metabolic processGO:0067669.3TPK1, THTPA
6tricarboxylic acid cycleGO:0060999.2OGDH, DLST
7thiamine metabolic processGO:0067729.0TKTL1, TPK1, THTPA
8water-soluble vitamin metabolic processGO:0067679.0TPK1, THTPA
9generation of precursor metabolites and energyGO:0060918.7OGDH, DLST, THTPA
10small molecule metabolic processGO:0442817.3THTPA, APOE, TPK1, ACHE, DLST, OGDH

Molecular functions related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid bindingGO:0015409.7ACHE, APOE
2transketolase activityGO:0048029.4TKT, TKTL1

Products for genes affiliated with Wernicke-Korsakoff Syndrome

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Sources for Wernicke-Korsakoff Syndrome

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4CDC
13ExPASy
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22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet