MCID: WRN002
MIFTS: 56

Wernicke-Korsakoff Syndrome malady

Rare diseases, Metabolic diseases categories
Download this MalaCard

Summaries for Wernicke-Korsakoff Syndrome

About this section


Fully expand this MalaCard
NINDS:43 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. Symptoms include mental confusion, vision impairment, stupor, coma, hypothermia, hypotension, and ataxia. -a memory disorder-also results from a deficiency of thiamine, and is associated with alcoholism. The heart, vascular, and nervous system are involved. Symptoms include amnesia, confabulation, attention deficit, disorientation, and vision impairment. The main features of Korsakoff's amnesic syndrome are the impairments in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's may appear to be two different disorders, they are generally considered to be different stages of the same disorder, which is called . Wernicke's encephalopathy represents the "acute" phase of the disorder, and Korsakoff's amnesic syndrome represents the "chronic" phase.

MalaCards based summary: Wernicke-Korsakoff Syndrome, also known as alcohol induced encephalopathy, is related to alzheimer's disease and cerebritis, and has symptoms including An important gene associated with Wernicke-Korsakoff Syndrome is TKT (transketolase), and among its related pathways are Pentose Phosphate Pathway and Citric acid cycle (TCA cycle). The drugs chlordiazepoxide and citalopram and the compounds thiamin diphosphate and rivastigmine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are other and nervous system.

NIH Rare Diseases:42 Wernicke-korsakoff syndrome is a brain disorder due to thiamine deficiency that has been associated with both wernicke's encephalopathy and korsakoff syndrome. wernicke's encephalopathy can result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. korsakoff's amnesic syndrome is a memory disorder that is associated with alcoholism and involvement of the heart, vascular, and nervous system. although these conditions may appear to be two different disorders, they are generally considered to be different stages of wernicke-korsakoff syndrome. wernicke's encephalopathy represents the "acute" phase and korsakoff's amnesic syndrome represents the "chronic" phase. last updated: 10/20/2011

Wikipedia:65 Wernicke?Korsakoff syndrome (WKS)?also called wet brain, Korsakoff\'s psychosis, and alcoholic... more...

Description from OMIM:46 277730

Aliases & Classifications for Wernicke-Korsakoff Syndrome

About this section

Wernicke-Korsakoff Syndrome, Aliases & Descriptions:

Name: Wernicke-Korsakoff Syndrome 8 42 43 10 62
Alcohol Induced Encephalopathy 42 62
Korsakoff's Amnesic Syndrome 42 43
Transketolase Defect 42 62
Korsakoff Syndrome 8 44
Alcoholic Intoxication, Chronic 62
 
Wernicke-Korsakov Syndrome 8
Wernicke's Encephalopathy 42
Korsakoff's Psychosis 8
Korsakoff's Syndrome 8
Korsakov's Psychosis 8
Korsakov Psychosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases


External Ids:

Disease Ontology8 DOID:10915
OMIM46 277730
MeSH34 D020915

Related Diseases for Wernicke-Korsakoff Syndrome

About this section

Graphical network of the top 20 diseases related to Wernicke-Korsakoff Syndrome:



Diseases related to wernicke-korsakoff syndrome

Symptoms for Wernicke-Korsakoff Syndrome

About this section


Clinical features from OMIM:

277730

HPO human phenotypes related to Wernicke-Korsakoff Syndrome:

(show all 10)
id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 ptosis HP:0000508
3 ophthalmoplegia HP:0000602
4 horizontal nystagmus HP:0000666
5 psychosis HP:0000709
6 ataxia HP:0001251
7 coma HP:0001259
8 polyneuropathy HP:0001271
9 confusion HP:0001289
10 memory impairment HP:0002354

Drugs & Therapeutics for Wernicke-Korsakoff Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Wernicke-Korsakoff Syndrome

Search NIH Clinical Center for Wernicke-Korsakoff Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Wernicke-Korsakoff Syndrome

About this section

Anatomical Context for Wernicke-Korsakoff Syndrome

About this section

MalaCards organs/tissues related to Wernicke-Korsakoff Syndrome:

32
Brain, Heart, Liver, Testes, T cells

Animal Models for Wernicke-Korsakoff Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Wernicke-Korsakoff Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.8DLST, FOXB1, APOE
2MP:00036318.3TKT, DLST, ACHE, FOXB1, APOE
3MP:00053868.0APOE, FOXB1, ACHE, DLST, TKT
4MP:00053787.8TKT, APOE, FOXB1, ACHE, DLST, TKTL1

Publications for Wernicke-Korsakoff Syndrome

About this section

Articles related to Wernicke-Korsakoff Syndrome:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Neural Correlate of Anterograde Amnesia in Wernicke-Korsakoff Syndrome. (25148770)
2014
2
Wernicke-korsakoff syndrome in primary peritoneal cancer. (24474922)
2013
3
Biomarkers of delirium as a clue to diagnosis and pathogenesis of Wernicke-Korsakoff syndrome. (23790077)
2013
4
Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome. (22192411)
2012
5
Teaching neuroimages: bilateral anterior thalami and fornix macrohemorrhage in Wernicke-Korsakoff syndrome. (22123785)
2011
6
Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study. (19960210)
2010
7
Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. (20364001)
2010
8
Neuroimaging of the Wernicke-Korsakoff syndrome. (19066199)
2009
9
Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. (18379741)
2008
10
Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency. (18584388)
2008
11
A clinical and radiographic variant of Wernicke-Korsakoff syndrome in a nonalcoholic patient. (17159109)
2006
12
Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome. (15922063)
2005
13
Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). (16015585)
2005
14
Increased cerebellar PET glucose metabolism corresponds to ataxia in Wernicke-Korsakoff syndrome. (14998834)
2004
15
Wernicke-Korsakoff syndrome and galantamine. (15232056)
2004
16
Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse. (14974055)
2004
17
Wernicke-Korsakoff syndrome and alcohol-induced persistent dementia. (15555036)
2004
18
A placebo-controlled study of memantine (Ebixa) in dementia of Wernicke-Korsakoff syndrome. (12858653)
2003
19
Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers. (12454526)
2002
20
Memory loss and ataxia after hyperemesis gravidarum: a case of Wernicke-Korsakoff syndrome. (12039101)
2002
21
No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (11445257)
2001
22
Wernicke-Korsakoff syndrome in Sydney hospitals after 6 years of thiamin enrichment of bread. (10933408)
1998
23
Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference? (9640303)
1998
24
A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. (9194907)
1997
25
"Grievous bodily harm:" gamma hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome. (8614515)
1996
26
Chronic alcoholics without Wernicke-Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus. (8651464)
1996
27
Preventing the Wernicke-Korsakoff syndrome in Australia: cost-effectiveness of thiamin-supplementation alternatives. (8799094)
1996
28
An international perspective on the prevalence of the Wernicke-Korsakoff syndrome. (7596325)
1995
29
Molecular genetics of transketolase in the pathogenesis of the Wernicke-Korsakoff syndrome. (7596328)
1995
30
Neuropathological correlates of memory dysfunction in the Wernicke-Korsakoff syndrome. (8974343)
1994
31
Wernicke-Korsakoff syndrome following attempted hanging. (8235215)
1993
32
Wernicke-Korsakoff syndrome. (1821238)
1991
33
Wernicke-Korsakoff syndrome complicating T-cell lymphoma: unusual or unrecognized? (1990464)
1991
34
The changing face of the Wernicke-Korsakoff syndrome. (16840155)
1990
35
MR in the diagnosis of Wernicke-Korsakoff syndrome. (2122686)
1990
36
Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. (2675860)
1989
37
A comparison of brainstem auditory evoked responses evoked by rarefaction and condensation stimulation in control subjects and in patients with Wernicke-Korsakoff syndrome and multiple sclerosis. (3734836)
1986
38
Abstinence improves cerebral perfusion and brain volume in alcoholic neurotoxicity without Wernicke-Korsakoff syndrome. (3944220)
1986
39
The Wernicke-Korsakoff syndrome in Queensland, Australia: antecedents and prevention. (4052158)
1985
40
Some observations on the Wernicke Korsakoff syndrome in Australia. (3856451)
1985
41
Cerebral atrophy and hypoperfusion improve during treatment of Wernicke-Korsakoff syndrome. (4030916)
1985
42
Wernicke-Korsakoff syndrome. (6697048)
1984
43
Is there a genetic component to the pathogenesis of the Wernicke-Korsakoff syndrome? (6508876)
1984
44
Computed tomographic findings in Wernicke-Korsakoff syndrome. (6703950)
1984
45
Erythrocyte transketolase activity in the Wernicke-Korsakoff syndrome. (7306754)
1981
46
The Wernicke-Korsakoff syndrome. (7424767)
1980
47
Prevention of the Wernicke-Korsakoff syndrome: an updated cost-benefit analysis. (104174)
1979
48
Long-term therapy for the mental disturbances of Wernicke-Korsakoff syndrome. (845586)
1977
49
The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. (5162155)
1971
50
Cerebral blood flow and metabolism in the Wernicke-Korsakoff syndrome. (6025486)
1967

Variations for Wernicke-Korsakoff Syndrome

About this section

Expression for genes affiliated with Wernicke-Korsakoff Syndrome

About this section
Expression patterns in normal tissues for genes affiliated with Wernicke-Korsakoff Syndrome

Search GEO for disease gene expression data for Wernicke-Korsakoff Syndrome.

Pathways for genes affiliated with Wernicke-Korsakoff Syndrome

About this section

Pathways related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)37
pentose phosphate pathway37
PRPP biosynthesis37
9.7TKT, TKTL1
2
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.3OGDH, DLST
39.3DLST, OGDH
49.3THTPA, TPK1
5
Show member pathways
flavin biosynthesis IV (mammalian)37
molybdenum cofactor biosynthesis37
coenzyme A biosynthesis37
thiamin salvage III37
alanine biosynthesis III37
thio-molybdenum cofactor biosynthesis37
biotin-carboxyl carrier protein assembly37
9.3TPK1, THTPA
69.1TKT, DLST, APOE
7
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
8.6TKT, TKTL1, OGDH, DLST
8
Show member pathways
6.6TKT, THTPA, APOE, TPK1, ACHE, DLST

Compounds for genes affiliated with Wernicke-Korsakoff Syndrome

About this section

Compounds related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1thiamin diphosphate4410.2TPK1, TKT
2rivastigmine44 1111.1APOE, ACHE
3Xylulose 5-phosphate2410.1TKTL1, TKT
4Sedoheptulose2410.1TKTL1, TKT
5metrifonate4410.1APOE, ACHE
6D-Sedoheptulose 7-phosphate2410.1TKTL1, TKT
7cdp choline4410.0APOE, ACHE
8D-Erythrose 4-phosphate2410.0TKT, TKTL1
9tacrine44 1111.0APOE, ACHE
10D-Ribose 5-phosphate2410.0TKT, TKTL1
11D-Ribulose 5-phosphate2410.0TKT, TKTL1
12donepezil44 50 24 1113.0APOE, ACHE
13galantamine44 50 1111.9APOE, ACHE
14Beta-D-Fructose 6-phosphate249.9TKT, TKTL1
15parathion44 2410.9TKT, ACHE
16tetrodotoxin44 61 2811.7ACHE, APOE
17(S)-Succinyldihydrolipoamide249.7DLST, OGDH
18S-Glutaryldihydrolipoamide249.7OGDH, DLST
19glutaryl-coa44 2410.7DLST, OGDH
20thiamine triphosphate44 2410.7THTPA, TPK1
21thiamine monophosphate44 2410.7TPK1, OGDH, TKT
22dihydrolipoamide44 2410.6OGDH, DLST
23glucose 6-phosphate44 2410.6TKT, OGDH
24Succinyl-CoA249.6DLST, OGDH
25nmda44 2810.6APOE, ACHE, TKT
26glutamine449.3APOE, OGDH, TKT
274-hydroxynonenal44 2410.2OGDH, APOE
28creatinine449.1APOE, OGDH, TKT
29glutamate449.1TKT, OGDH, ACHE, APOE
30alpha-ketoglutarate449.0TKT, OGDH, DLST, TPK1
31pyruvate449.0TPK1, DLST, OGDH, TKT
32atp44 289.6TKT, OGDH, TPK1, THTPA
33thiamine44 2 24 1111.4THTPA, APOE, TPK1, OGDH, TKT
34thiamine pyrophosphate44 249.4TKT, TKTL1, OGDH, TPK1, THTPA

GO Terms for genes affiliated with Wernicke-Korsakoff Syndrome

About this section

Cellular components related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxoglutarate dehydrogenase complexGO:0452529.3OGDH, DLST

Biological processes related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:0072719.7APOE, ACHE
2thalamus developmentGO:0217949.5OGDH, FOXB1
3lysine catabolic processGO:0065549.4OGDH, DLST
4thiamine-containing compound metabolic processGO:0427239.4THTPA, TPK1
5vitamin metabolic processGO:0067669.3TPK1, THTPA
6tricarboxylic acid cycleGO:0060999.2OGDH, DLST
7thiamine metabolic processGO:0067729.0TKTL1, TPK1, THTPA
8water-soluble vitamin metabolic processGO:0067679.0TPK1, THTPA
9generation of precursor metabolites and energyGO:0060918.7OGDH, DLST, THTPA
10small molecule metabolic processGO:0442817.3THTPA, APOE, TPK1, ACHE, DLST, OGDH

Molecular functions related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid bindingGO:0015409.7ACHE, APOE
2transketolase activityGO:0048029.4TKT, TKTL1

Products for genes affiliated with Wernicke-Korsakoff Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Wernicke-Korsakoff Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet