MCID: WRN002
MIFTS: 51

Wernicke-Korsakoff Syndrome malady

Summaries for Wernicke-Korsakoff Syndrome

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42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. Symptoms include mental confusion, vision impairment, stupor, coma, hypothermia, hypotension, and ataxia. -a memory disorder-also results from a deficiency of thiamine, and is associated with alcoholism. The heart, vascular, and nervous system are involved. Symptoms include amnesia, confabulation, attention deficit, disorientation, and vision impairment. The main features of Korsakoff's amnesic syndrome are the impairments in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's may appear to be two different disorders, they are generally considered to be different stages of the same disorder, which is called . Wernicke's encephalopathy represents the "acute" phase of the disorder, and Korsakoff's amnesic syndrome represents the "chronic" phase.

MalaCards: Wernicke-Korsakoff Syndrome, also known as alcohol induced encephalopathy, is related to wernicke encephalopathy and beriberi. An important gene associated with Wernicke-Korsakoff Syndrome is SLC19A2 (solute carrier family 19 (thiamine transporter), member 2), and among its related pathways are Vitamin digestion and absorption and Pentose phosphate pathway (hexose monophosphate shunt). The drugs chlordiazepoxide and citalopram and the compounds [3h]thiamine and rivastigmine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are growth/size and behavior/neurological.

NIH Rare Diseases:42 Wernicke-korsakoff syndrome is a brain disorder due to thiamine deficiency that has been associated with both wernicke's encephalopathy and korsakoff syndrome. wernicke's encephalopathy can result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. korsakoff's amnesic syndrome is a memory disorder that is associated with alcoholism and involvement of the heart, vascular, and nervous system. although these conditions may appear to be two different disorders, they are generally considered to be different stages of wernicke-korsakoff syndrome. wernicke's encephalopathy represents the "acute" phase and korsakoff's amnesic syndrome represents the "chronic" phase. last updated: 10/20/2011

Wikipedia:63 Wernicke–Korsakoff syndrome (WKS)—also called wet brain, Korsakoff\'s psychosis, and alcoholic... more...

Description from OMIM:46 277730

Aliases & Classifications for Wernicke-Korsakoff Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 46OMIM, 34MeSH
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Aliases & Descriptions:

wernicke-korsakoff syndrome 8 42 43 10 60
alcohol induced encephalopathy 42 60
korsakoff's amnesic syndrome 42 43
transketolase defect 42 60
korsakoff syndrome 8 44
alcoholic intoxication, chronic 60
wernicke-korsakov syndrome 8
wernicke's encephalopathy 42
korsakoff's psychosis 8
korsakoff's syndrome 8
korsakov's psychosis 8
korsakov psychosis 8


External Ids:

Disease Ontology8 DOID:10915
OMIM46 277730
MeSH34 D020915

Related Diseases for Wernicke-Korsakoff Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Wernicke-Korsakoff Syndrome:



Diseases related to wernicke-korsakoff syndrome

Clinical Features for Wernicke-Korsakoff Syndrome

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46OMIM
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Clinical features from OMIM:

277730

Drugs & Therapeutics for Wernicke-Korsakoff Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Wernicke-Korsakoff Syndrome

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Anatomical Context for Wernicke-Korsakoff Syndrome

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32MalaCards
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MalaCards organs/tissues related to Wernicke-Korsakoff Syndrome:

32
Brain, Heart, Liver, Testes, T cells

Animal Models for Wernicke-Korsakoff Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Wernicke-Korsakoff Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.8APOE, FOXB1, DLST, TKTL1, TKT, SLC19A3
2MP:00053867.6APOE, FOXB1, DLST, TKT, SLC19A3, SLC19A2

Publications for Wernicke-Korsakoff Syndrome

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50PubMed
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Articles related to Wernicke-Korsakoff Syndrome:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Biomarkers of delirium as a clue to diagnosis and pathogenesis of Wernicke-Korsakoff syndrome. (23790077)
2013
2
Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome. (22192411)
2012
3
Wernicke-Korsakoff-syndrome: under-recognized and under-treated. (23157990)
2012
4
Beyond alcoholism: Wernicke-Korsakoff syndrome in patients with psychiatric disorders. (22134191)
2011
5
Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study. (19960210)
2010
6
Neuroimaging of the Wernicke-Korsakoff syndrome. (19066199)
2009
7
Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. (18379741)
2008
8
Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency. (18584388)
2008
9
Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome. (15922063)
2005
10
Wernicke-Korsakoff syndrome associated with hyperemesis gravidarum. (16209289)
2005
11
Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome. (15817513)
2005
12
Eating avoidance disorder and Wernicke-Korsakoff syndrome following gastric bypass: an under-diagnosed association. (16197798)
2005
13
FDG-PET findings in the Wernicke-Korsakoff syndrome. (14584565)
2003
14
Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency? (12700319)
2003
15
Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation. (11902311)
2001
16
Prevention and treatment of Wernicke-Korsakoff syndrome. (11304070)
2000
17
Wernicke-Korsakoff syndrome and the use of brain imaging. (11304072)
2000
18
Wernicke-Korsakoff syndrome in head injury: a missed insult. (11304069)
2000
19
Wernicke-Korsakoff amnestic syndrome secondary to malnutrition in a patient with schizoaffective disorder. (9845417)
1998
20
Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference? (9640303)
1998
21
The nucleus basalis (Ch4) in the alcoholic Wernicke-Korsakoff syndrome: reduced cell number in both amnesic and non-amnesic patients. (9328247)
1997
22
Wernicke-Korsakoff syndrome. (9039406)
1997
23
B-complex vitamins in the prophylaxis and treatment of Wernicke-Korsakoff syndrome. (9274684)
1997
24
Preventing the Wernicke-Korsakoff syndrome in Australia: cost-effectiveness of thiamin-supplementation alternatives. (8799094)
1996
25
Wernicke-Korsakoff syndrome. (9305043)
1996
26
Wernicke-Korsakoff syndrome in a liver transplant recipient. (8942207)
1996
27
Molecular genetics of transketolase in the pathogenesis of the Wernicke-Korsakoff syndrome. (7596328)
1995
28
Wernicke-Korsakoff syndrome in Sydney hospitals: before and after thiamine enrichment of flour. (8538524)
1995
29
An enzymatic and immunochemical analysis of transketolase in fibroblasts from Wernicke-Korsakoff syndrome. (8445392)
1993
30
Wernicke-Korsakoff syndrome. (1821238)
1991
31
Increased central immunoreactive beta-endorphin content in patients with Wernicke-Korsakoff syndrome and in alcoholics. (1650797)
1991
32
Wernicke-Korsakoff syndrome sans alcohol. (1814894)
1991
33
The changing face of the Wernicke-Korsakoff syndrome. (16840155)
1990
34
MR in the diagnosis of Wernicke-Korsakoff syndrome. (2122686)
1990
35
Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. (2675860)
1989
36
The prevalence of the Wernicke-Korsakoff syndrome in Sydney, Australia: a prospective necropsy study. (2784828)
1989
37
The Wernicke-Korsakoff syndrome: a reappraisal in Queensland with special reference to prevention. (3696045)
1987
38
Abstinence improves cerebral perfusion and brain volume in alcoholic neurotoxicity without Wernicke-Korsakoff syndrome. (3944220)
1986
39
Is there a genetic component to the pathogenesis of the Wernicke-Korsakoff syndrome? (6508876)
1984
40
Computed tomographic findings in Wernicke-Korsakoff syndrome. (6703950)
1984
41
An erythrocyte transketolase isoenzyme pattern associated with the Wernicke-Korsakoff syndrome. (6434322)
1984
42
Wernicke-Korsakoff syndrome. (6360274)
1983
43
Pseudohypoglycaemia in acute renal failure with Wernicke-Korsakoff syndrome. (7110480)
1982
44
Wernicke-Korsakoff syndrome in monozygotic twins: a biochemical peculiarity. (7197998)
1981
45
The Wernicke-Korsakoff syndrome: a review of psychological, neuropathological and etiological factors. (6806017)
1981
46
Hypothermia and coma in the Wernicke-Korsakoff syndrome. (7207347)
1980
47
Prevention of the Wernicke-Korsakoff syndrome: an updated cost-benefit analysis. (104174)
1979
48
How common is Wernicke-Korsakoff syndrome? (80700)
1978
49
Cerebral blood flow and metabolism in the Wernicke-Korsakoff syndrome. (6025486)
1967
50
A psychological study of the Wernicke-Korsakoff syndrome. Results of Wechsler-Bellevue intelligence scale and Wechsler memory scale testing at different stages in the disease. (13842087)
1959

Genetic Variations for Wernicke-Korsakoff Syndrome

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Expression for genes affiliated with Wernicke-Korsakoff Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wernicke-Korsakoff Syndrome

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Pathways for genes affiliated with Wernicke-Korsakoff Syndrome

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Wernicke-Korsakoff Syndrome

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28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1[3h]thiamine2810.2SLC19A3, SLC19A2
2rivastigmine44 1111.1APOE, ACHE
3metrifonate4410.0ACHE, APOE
4cdp choline4410.0ACHE, APOE
5thiamin diphosphate4410.0TPK1, TKT
6tacrine44 1110.9ACHE, APOE
7donepezil44 11 2411.8ACHE, APOE
8(S)-Succinyldihydrolipoamide249.6OGDH, DLST
9thiamine triphosphate44 2410.6THTPA, TPK1
10galantamine44 49 1111.6APOE, ACHE
11thiamine monophosphate44 2410.6OGDH, TKT, TPK1
12glutaryl-coa44 2410.5OGDH, DLST
13dihydrolipoamide44 2410.4OGDH, DLST
14magnesium44 11 2411.0TPK1, TKTL2, TKT, TKTL1
15alpha-ketoglutarate448.9TPK1, TKT, DLST, OGDH
16pyruvate448.9OGDH, DLST, TKT, TPK1
17thiamine pyrophosphate44 248.9OGDH, TKTL1, TKT, TKTL2, THTPA, TPK1
18thiamine44 2 11 2410.9TPK1, OGDH, APOE, TKT, THTPA, SLC19A3

GO Terms for genes affiliated with Wernicke-Korsakoff Syndrome

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16Gene Ontology
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Cellular components related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxoglutarate dehydrogenase complexGO:0452529.3DLST, OGDH

Biological processes related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:0072719.6ACHE, APOE
2lysine catabolic processGO:0065549.3DLST, OGDH
3thalamus developmentGO:0217949.3FOXB1, OGDH
4tricarboxylic acid cycleGO:0060999.3DLST, OGDH
5thiamine metabolic processGO:0067729.2TKTL1, THTPA, TPK1
6thiamine-containing compound metabolic processGO:0427239.0TPK1, SLC19A2, SLC19A3, THTPA
7water-soluble vitamin metabolic processGO:0067679.0THTPA, SLC19A3, SLC19A2, TPK1
8vitamin metabolic processGO:0067668.9TPK1, SLC19A2, SLC19A3, THTPA
9generation of precursor metabolites and energyGO:0060918.6OGDH, DLST, THTPA
10small molecule metabolic processGO:0442816.9OGDH, APOE, DLST, TKT, THTPA, SLC19A3

Molecular functions related to Wernicke-Korsakoff Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thiamine uptake transmembrane transporter activityGO:01540310.0SLC19A2, SLC19A3
2beta-amyloid bindingGO:0015409.9ACHE, APOE
3reduced folate carrier activityGO:0085189.9SLC19A3, SLC19A2
4folic acid bindingGO:0055429.7SLC19A2, SLC19A3
5transketolase activityGO:0048029.4TKTL2, TKT, TKTL1

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