MCID: WST004
MIFTS: 38

West Nile Encephalitis malady

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for West Nile Encephalitis

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Aliases & Descriptions for West Nile Encephalitis:

Name: West Nile Encephalitis 11 46 13
West Nile Fever with Encephalitis 11
Encephalitis, West Nile Fever 66
West Nile Fever Encephalitis 11
 
West-Nile Encephalitis 52
West-Nile Fever 52
West Nile Fever 37

Characteristics:

Orphanet epidemiological data:

52
west-nile encephalitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:2365
ICD1028 A92.31
ICD9CM30 066.41
SNOMED-CT60 392662004
MeSH37 D014901
Orphanet52 ORPHA83476
ICD10 via Orphanet29 A92.3

Summaries for West Nile Encephalitis

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Disease Ontology:11 A viral infectious disease that results in inflammation located in brain, has material basis in west nile virus, which is transmitted by culex, transmitted by aedes, and transmitted by anopheles species of mosquitoes. the infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

MalaCards based summary: West Nile Encephalitis, also known as west nile fever with encephalitis, is related to encephalitis and kunjin encephalitis, and has symptoms including high fever, headache and neck stiffness. An important gene associated with West Nile Encephalitis is OAS1 (2'-5'-Oligoadenylate Synthetase 1), and among its related pathways are Hepatitis C and Interferon gamma signaling. Affiliated tissues include brain, brain and b cells.

Related Diseases for West Nile Encephalitis

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Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis10.8
2kunjin encephalitis10.3
3west nile fever10.3
4west nile virus10.2
5neuronitis10.1
6meningitis10.1
7malaria9.9
8japanese encephalitis9.9
9status epilepticus9.9
10myelitis9.9
11pneumonia9.9
12lymphopenia9.9
13diabetes insipidus9.9
14opsoclonus-myoclonus syndrome9.9
15myoclonus9.9
16erythema multiforme9.9OAS1, OAS3
17human monocytic ehrlichiosis9.4BST2, OAS3
18neuroaxonal dystrophy7.9BST2, INVS, MID2, OAS1, OAS3

Graphical network of diseases related to West Nile Encephalitis:



Diseases related to west nile encephalitis

Symptoms for West Nile Encephalitis

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Symptoms:

 11 (show all 12)
  • high fever
  • headache
  • neck stiffness
  • stupor
  • disorientation
  • coma
  • tremors
  • convulsions
  • muscle weakness
  • vision loss
  • numbness
  • paralysis

Drugs & Therapeutics for West Nile Encephalitis

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Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinPhase 296836791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2
GlycineNutraceuticalPhase 1, Phase 219856-40-6750
Synonyms:
(1-13c)glycinato
(15N)Glycine
15527_RIEDEL
15527_SIAL
15743-44-9 (mono-potassium salt)
17829-66-2 (cobalt salt)
18875-39-3
2,2-dialkylglycines
2-Aminoacetate
2-Aminoacetic acid
2311-65-1
25718-94-9
29728-27-6 (monoammonium salt)
32817-15-5 (copper salt)
33226_RIEDEL
33226_SIAL
33242-26-1 (calcium salt)
35947-07-0 (calcium salt (2:1))
410225_SIAL
50046_FLUKA
50046_SIGMA
513-29-1 (sulfate (3:1))
52955-63-2
56-40-6
57678-19-0
6000-43-7 (hydrochloride)
6000-44-8 (mono-hydrochloride salt)
63183-41-5 (hydrochloride hydrogen carbonate)
71295-98-2 (phosphate (1:1))
7490-95-1 (hydrochloride (2:1)
7490-95-1 (hydrochloride (2:1))
7575-55-5
848646-45-7
87867-94-5
AB-131/40217813
AB1002628
AC1L19XW
AC1Q28JW
AC1Q53O0
AI3-04085
AKOS000119626
AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER
AR-1A0345
AR-1A0532
Acide aminoacetique
Acide aminoacetique [INN-French]
Acido aminoacetico
Acido aminoacetico [INN-Spanish]
Acidum aminoaceticum
Acidum aminoaceticum [INN-Latin]
Aciport
Amino-Acetate
Amino-Acetic acid
Aminoacetate
Aminoacetic acid
Aminoazijnzuur
Aminoessigsaeure
Aminoethanoate
Aminoethanoic acid
Amitone
B72BA06C-60E9-4A83-A24A-A2D7F465BB65
BPBio1_001222
Biomol-NT_000195
C00037
CCRIS 5915
CHEBI:15428
CHEBI:15705
CHEBI:16228
CHEMBL773
CID750
CPD-8569
Corilin
D00011
DB00145
EINECS 200-272-2
 
FEMA No. 3287
FT-0083159
G
G0099
G0317
G5417_SIGMA
G5523_SIGMA
G7126_SIGMA
G7403_SIGMA
G8790_SIGMA
G8898_SIGMA
GLY (IUPAC abbrev)
GLYCINE 1.5% IN PLASTIC CONTAINER
GLYCINE, ACS
Glicina
Glicina [INN-Spanish]
Glicoamin
Gly
Glycin
Glycine
Glycine (JP15/USP)
Glycine [INN]
Glycine iron sulphate (1:1)
Glycine, homopolymer (VAN)
Glycine, labeled with carbon-14
Glycine, non-medical
Glycine-UL-14C hydrochloride
Glycinum
Glycinum [INN-Latin]
Glycocoll
Glycolixir
Glycosthene
Glykokoll
Glyzin
Gyn-Hydralin
Gyn-hydralin
H-Gly-OH
H2N-CH2-COOH
HSDB 495
Hampshire glycine
Hgly
InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5
KST-1A2919
KST-1A8102
L-Glycine
L-alpha-amino acids
L001246
LS-218
Leimzucker
MolPort-000-871-607
NCGC00024503-01
NCGC00024503-02
NChemBio.2007.13-comp1
NSC 25936
NSC25936
P8791_SIGMA
Padil
Polyglycine II
S04-0135
Sucre de gelatine
Tocris-0219
UNII-TE7660XO1C
W328707_ALDRICH
WLN: Z1VQ
aminoacetic acid
an alpha amino acid ester
bmse000089
gly
glycine
nchem.554-comp2
nchembio.121-comp9
nchembio.145-comp33
nchembio.198-comp12
nchembio.265-comp9
nchembio.266-comp30
polyglycine
3
nivolumab254946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1IVIG - West Nile Encephalitis: Safety and EfficacyCompletedNCT00068055Phase 1, Phase 2
2Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus DiseaseCompletedNCT00069316Phase 2
3Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese EncephalitisCompletedNCT01856205Phase 2
4Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy AdultsCompletedNCT00442169Phase 2
5Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy AdultsCompletedNCT00746798Phase 2
6Treatment of Japanese EncephalitisRecruitingNCT00216268Phase 2
7Treatment of West Nile Virus With MGAWN1TerminatedNCT00927953Phase 2
8Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy AdultsCompletedNCT00094718Phase 1
9Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy AdultsCompletedNCT00537147Phase 1
10Phase I Study of West Nile Virus VaccineCompletedNCT00300417Phase 1
11Vaccine to Prevent West Nile Virus DiseaseCompletedNCT00106769Phase 1
12Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal FluidCompletedNCT00381433Phase 1
13Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of AgeActive, not recruitingNCT02186626Phase 1
14An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) DiseaseTerminatedNCT00091845Phase 1
15Natural History of West Nile Virus InfectionCompletedNCT00069303
16Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
17Pattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology PracticeRecruitingNCT02847728
18Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental ExposureNo longer availableNCT01206504

Search NIH Clinical Center for West Nile Encephalitis


Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

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Anatomical Context for West Nile Encephalitis

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MalaCards organs/tissues related to West Nile Encephalitis:

34
Brain, B cells, Occipital lobe, T cells

FMA organs/tissues related to West Nile Encephalitis:

17
Brain

Animal Models for West Nile Encephalitis or affiliated genes

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Publications for West Nile Encephalitis

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Articles related to West Nile Encephalitis:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Outcomes of West Nile encephalitis patients after one year of West Nile encephalitis outbreak in Kerala, India: A follow-up study. (27061922)
2016
2
Three Cases of West Nile Encephalitis over an Eight-Day Period at a Downtown Los Angeles Community Hospital. (26106493)
2015
3
West Nile Encephalitis and Its Characteristics in Childhood. (26199702)
2015
4
Manifestation of West Nile Encephalitis in Infancy. (26501475)
2015
5
The first reported case of West Nile encephalitis in Korea. (25729260)
2015
6
Emergence of Equine West Nile Encephalitis in Central Macedonia, Greece, 2010. (25660661)
2015
7
Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report. (24968889)
2014
8
West Nile encephalitis outbreak in Kerala, India, 2011. (24985196)
2014
9
C-65Neurocognitive Rehabilitation of a West Nile Encephalitis Survivor. (25176908)
2014
10
The 2012 West Nile encephalitis epidemic in Dallas, Texas. (23860988)
2013
11
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? (23427877)
2013
12
An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. (23864620)
2013
13
Locally acquired West Nile encephalitis. (21865003)
2012
14
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. (20660705)
2010
15
OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses. (20479874)
2010
16
The host immunologic response to West Nile encephalitis virus. (19273254)
2009
17
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. (19141700)
2009
18
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. (19200759)
2009
19
Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population. (18453596)
2008
20
Efficacy and durability of a recombinant subunit West Nile vaccine candidate in protecting hamsters from West Nile encephalitis. (17067727)
2007
21
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. (17630998)
2007
22
Opsoclonus persisting during sleep in West Nile encephalitis. (16966514)
2006
23
Potentiation of West Nile encephalitis by mosquito feeding. (16553552)
2006
24
West Nile encephalitis relapse presenting with abducens and facial nerve palsies. (16750946)
2006
25
West Nile encephalitis mimicking herpes encephalitis. (16814089)
2006
26
Use of interferon-alpha in patients with West Nile encephalitis: report of 2 cases. (15714427)
2005
27
Rhabdomyolysis in patients with west nile encephalitis and meningitis. (16187894)
2005
28
Differential diagnosis of West Nile encephalitis. (15353960)
2004
29
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World. (15550172)
2004
30
Listeria monocytogenes encephalitis mimicking West Nile encephalitis. (14983142)
2004
31
An occipital lobe epileptogenic focus in a patient with West Nile encephalitis. (14748771)
2004
32
Serum ferritin levels in West Nile encephalitis. (14759247)
2004
33
Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disorders. (12766856)
2003
34
Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. (14583143)
2003
35
Muscle weakness in West Nile encephalitis is due to destruction of motor neurons. (12827621)
2003
36
B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. (12551996)
2003
37
Infection and injury of neurons by West Nile encephalitis virus. (14645577)
2003
38
West Nile encephalitis. (12436096)
2002
39
Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. (11927020)
2002
40
Print media coverage of risk-risk tradeoffs associated with West Nile encephalitis and pesticide spraying. (12468668)
2002
41
West Nile encephalitis in Israel, 1999: the New York connection. (11585528)
2001
42
West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. (11585537)
2001
43
Equine West Nile encephalitis, United States. (11589171)
2001
44
Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey. (11498211)
2001
45
Epidemic West Nile encephalitis in Romania: waiting for history to repeat itself. (11797808)
2001
46
West Nile encephalitis: an emerging disease in the United States. (11595987)
2001
47
Profound and prolonged lymphocytopenia with West Nile encephalitis. (11049802)
2000
48
The role of pathology in an investigation of an outbreak of West Nile encephalitis in New York, 1999. (10905969)
2000
49
West Nile Encephalitis: What it could mean to Canadian paediatricians in the summer of 2000. (20177527)
2000
50
West Nile encephalitis epidemic in southeastern Romania. (9737281)
1998

Variations for West Nile Encephalitis

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Expression for genes affiliated with West Nile Encephalitis

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Search GEO for disease gene expression data for West Nile Encephalitis.

Pathways for genes affiliated with West Nile Encephalitis

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Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5OAS1, OAS3
2
Show member pathways
8.9BST2, OAS1, OAS3
3
Show member pathways
8.9BST2, OAS1, OAS3

GO Terms for genes affiliated with West Nile Encephalitis

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Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:00603339.9OAS1, OAS3
2positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.7BST2, MID2
3type I interferon signaling pathwayGO:00603379.4BST2, OAS1, OAS3
4negative regulation of viral genome replicationGO:00450719.3BST2, OAS1, OAS3
5defense response to virusGO:00516078.9BST2, OAS1, OAS3
6response to virusGO:00096158.6BST2, OAS1, OAS3

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
12-5-oligoadenylate synthetase activityGO:00017309.9OAS1, OAS3
2double-stranded RNA bindingGO:00037259.5OAS1, OAS3

Sources for West Nile Encephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet