MCID: WST004
MIFTS: 39

West Nile Encephalitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for West Nile Encephalitis

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Aliases & Descriptions for West Nile Encephalitis:

Name: West Nile Encephalitis 11 48 13
West Nile Fever 39 68
West Nile Fever with Encephalitis 11
 
Encephalitis, West Nile Fever 68
West Nile Fever Encephalitis 11

Classifications:



External Ids:

Disease Ontology11 DOID:2365
ICD1030 A92.31
SNOMED-CT62 392662004
ICD9CM32 066.41
MeSH39 D014901

Summaries for West Nile Encephalitis

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NIH Rare Diseases:48 West nile encephalitis is a form of west nile virus that affects the neurological system. signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures, paralysis, or coma. west nile virus is generally spread to humans by infected mosquitos. west nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system. although west nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer, diabetes, hypertension, and kidney disease have the highest risk of developing the condition. treatment is supportive and hospitalization may be required to address the associated symptoms. recovery may take several weeks or months and some of the neurologic effects may be permanent. last updated: 10/14/2016

MalaCards based summary: West Nile Encephalitis, also known as west nile fever, is related to west nile virus and kunjin encephalitis, and has symptoms including high fever, headache and neck stiffness. An important gene associated with West Nile Encephalitis is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways are Hepatitis C and Interferon gamma signaling. The drug ribavirin has been mentioned in the context of this disorder. Affiliated tissues include brain, brain and kidney.

Disease Ontology:11 A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

Related Diseases for West Nile Encephalitis

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Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1west nile virus11.5
2kunjin encephalitis11.2
3west nile fever11.2
4encephalitis10.7
5argentine hemorrhagic fever10.0OAS1, OAS3
6neuronitis10.0
7meningitis10.0
8methylmalonic aciduria and homocystinuria, cblj type9.9OAS1, OAS3
9malaria9.8
10japanese encephalitis9.8
11status epilepticus9.8
12myelitis9.8
13pneumonia9.8
14lymphopenia9.8
15diabetes insipidus9.8
16opsoclonus-myoclonus syndrome9.8
17myoclonus9.8
18mineral metabolism disease9.7BST2, OAS1, OAS3
19hereditary elliptocytosis9.2BST2, INVS, MID2, OAS1, OAS3

Graphical network of diseases related to West Nile Encephalitis:



Diseases related to west nile encephalitis

Symptoms & Phenotypes for West Nile Encephalitis

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Symptoms:

 11 (show all 12)
  • high fever
  • headache
  • neck stiffness
  • stupor
  • disorientation
  • coma
  • tremors
  • convulsions
  • muscle weakness
  • vision loss
  • numbness
  • paralysis

Drugs & Therapeutics for West Nile Encephalitis

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Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 2100336791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2
Glycineapproved, nutraceutical, vet_approvedPhase 1, Phase 223256-40-6750
Synonyms:
(1-13c)glycinato
(15N)Glycine
15527_RIEDEL
15527_SIAL
15743-44-9 (mono-potassium salt)
17829-66-2 (cobalt salt)
18875-39-3
2,2-dialkylglycines
2-Aminoacetate
2-Aminoacetic acid
2311-65-1
25718-94-9
29728-27-6 (monoammonium salt)
32817-15-5 (copper salt)
33226_RIEDEL
33226_SIAL
33242-26-1 (calcium salt)
35947-07-0 (calcium salt (2:1))
410225_SIAL
50046_FLUKA
50046_SIGMA
513-29-1 (sulfate (3:1))
52955-63-2
56-40-6
57678-19-0
6000-43-7 (hydrochloride)
6000-44-8 (mono-hydrochloride salt)
63183-41-5 (hydrochloride hydrogen carbonate)
71295-98-2 (phosphate (1:1))
7490-95-1 (hydrochloride (2:1)
7490-95-1 (hydrochloride (2:1))
7575-55-5
848646-45-7
87867-94-5
AB-131/40217813
AB1002628
AC1L19XW
AC1Q28JW
AC1Q53O0
AI3-04085
AKOS000119626
AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER
AR-1A0345
AR-1A0532
Acide aminoacetique
Acide aminoacetique [INN-French]
Acido aminoacetico
Acido aminoacetico [INN-Spanish]
Acidum aminoaceticum
Acidum aminoaceticum [INN-Latin]
Aciport
Amino-Acetate
Amino-Acetic acid
Aminoacetate
Aminoacetic acid
Aminoazijnzuur
Aminoessigsaeure
Aminoethanoate
Aminoethanoic acid
Amitone
B72BA06C-60E9-4A83-A24A-A2D7F465BB65
BPBio1_001222
Biomol-NT_000195
C00037
CCRIS 5915
CHEBI:15428
CHEBI:15705
CHEBI:16228
CHEMBL773
CID750
CPD-8569
Corilin
D00011
DB00145
EINECS 200-272-2
 
FEMA No. 3287
FT-0083159
G
G0099
G0317
G5417_SIGMA
G5523_SIGMA
G7126_SIGMA
G7403_SIGMA
G8790_SIGMA
G8898_SIGMA
GLY (IUPAC abbrev)
GLYCINE 1.5% IN PLASTIC CONTAINER
GLYCINE, ACS
Glicina
Glicina [INN-Spanish]
Glicoamin
Gly
Glycin
Glycine
Glycine (JP15/USP)
Glycine [INN]
Glycine iron sulphate (1:1)
Glycine, homopolymer (VAN)
Glycine, labeled with carbon-14
Glycine, non-medical
Glycine-UL-14C hydrochloride
Glycinum
Glycinum [INN-Latin]
Glycocoll
Glycolixir
Glycosthene
Glykokoll
Glyzin
Gyn-Hydralin
Gyn-hydralin
H-Gly-OH
H2N-CH2-COOH
HSDB 495
Hampshire glycine
Hgly
InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5
KST-1A2919
KST-1A8102
L-Glycine
L-alpha-amino acids
L001246
LS-218
Leimzucker
MolPort-000-871-607
NCGC00024503-01
NCGC00024503-02
NChemBio.2007.13-comp1
NSC 25936
NSC25936
P8791_SIGMA
Padil
Polyglycine II
S04-0135
Sucre de gelatine
Tocris-0219
UNII-TE7660XO1C
W328707_ALDRICH
WLN: Z1VQ
aminoacetic acid
an alpha amino acid ester
bmse000089
gly
glycine
nchem.554-comp2
nchembio.121-comp9
nchembio.145-comp33
nchembio.198-comp12
nchembio.265-comp9
nchembio.266-comp30
polyglycine
3Anti-Infective AgentsPhase 222062
4Antiviral AgentsPhase 29967
5AntimetabolitesPhase 212054
6Pharmaceutical SolutionsPhase 1, Phase 28192
7VaccinesPhase 2, Phase 16611
8Immunoglobulins, IntravenousPhase 1, Phase 2333
9Rho(D) Immune GlobulinPhase 1, Phase 2326
10Immunoglobulin GPhase 1, Phase 2275
11ImmunoglobulinsPhase 1, Phase 26394
12AntibodiesPhase 1, Phase 26394
13gamma-GlobulinsPhase 1, Phase 2326
14Antibodies, MonoclonalPhase 24039
15
nivolumabapproved424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Treatment of Japanese EncephalitisUnknown statusNCT00216268Phase 2
2IVIG - West Nile Encephalitis: Safety and EfficacyCompletedNCT00068055Phase 1, Phase 2
3Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus DiseaseCompletedNCT00069316Phase 2
4Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese EncephalitisCompletedNCT01856205Phase 2
5Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy AdultsCompletedNCT00442169Phase 2
6Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy AdultsCompletedNCT00746798Phase 2
7Treatment of West Nile Virus With MGAWN1TerminatedNCT00927953Phase 2
8Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of AgeCompletedNCT02186626Phase 1
9Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy AdultsCompletedNCT00094718Phase 1
10Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy AdultsCompletedNCT00537147Phase 1
11Phase I Study of West Nile Virus VaccineCompletedNCT00300417Phase 1
12Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal FluidCompletedNCT00381433Phase 1
13Vaccine to Prevent West Nile Virus DiseaseCompletedNCT00106769Phase 1
14An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) DiseaseTerminatedNCT00091845Phase 1
15Natural History of West Nile Virus InfectionCompletedNCT00069303
16Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
17Pattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology PracticeRecruitingNCT02847728
18Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental ExposureNo longer availableNCT01206504

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

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Anatomical Context for West Nile Encephalitis

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MalaCards organs/tissues related to West Nile Encephalitis:

36
Brain, Kidney, B cells, Occipital lobe, T cells

FMA organs/tissues related to West Nile Encephalitis:

17
Brain

Publications for West Nile Encephalitis

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Articles related to West Nile Encephalitis:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Outcomes of West Nile encephalitis patients after one year of West Nile encephalitis outbreak in Kerala, India: A follow-up study. (27061922)
2016
2
A Case of West Nile Encephalitis That Develops into a Disease of Deep White Matter on MRI over a Two-Week Span. (27703823)
2016
3
West Nile Encephalitis and Its Characteristics in Childhood. (26199702)
2015
4
The first reported case of West Nile encephalitis in Korea. (25729260)
2015
5
Manifestation of West Nile Encephalitis in Infancy. (26501475)
2015
6
Three Cases of West Nile Encephalitis over an Eight-Day Period at a Downtown Los Angeles Community Hospital. (26106493)
2015
7
Emergence of Equine West Nile Encephalitis in Central Macedonia, Greece, 2010. (25660661)
2015
8
C-65Neurocognitive Rehabilitation of a West Nile Encephalitis Survivor. (25176908)
2014
9
West Nile encephalitis outbreak in Kerala, India, 2011. (24985196)
2014
10
Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report. (24968889)
2014
11
The 2012 West Nile encephalitis epidemic in Dallas, Texas. (23860988)
2013
12
An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. (23864620)
2013
13
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? (23427877)
2013
14
Locally acquired West Nile encephalitis. (21865003)
2012
15
IL-22 signaling contributes to West Nile encephalitis pathogenesis. (22952908)
2012
16
West Nile encephalitis presenting with severe persistent chills mimicking malaria. (22297291)
2011
17
OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses. (20479874)
2010
18
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. (20660705)
2010
19
Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis. (20509624)
2010
20
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. (19200759)
2009
21
The host immunologic response to West Nile encephalitis virus. (19273254)
2009
22
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. (19141700)
2009
23
Rhabdomyolysis in a patient with West Nile encephalitis and flaccid paralysis. (18488686)
2008
24
The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus. (18339459)
2008
25
Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population. (18453596)
2008
26
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. (17630998)
2007
27
Efficacy and durability of a recombinant subunit West Nile vaccine candidate in protecting hamsters from West Nile encephalitis. (17067727)
2007
28
Opsoclonus persisting during sleep in West Nile encephalitis. (16966514)
2006
29
West Nile encephalitis mimicking herpes encephalitis. (16814089)
2006
30
West Nile encephalitis relapse presenting with abducens and facial nerve palsies. (16750946)
2006
31
Potentiation of West Nile encephalitis by mosquito feeding. (16553552)
2006
32
Use of interferon-alpha in patients with West Nile encephalitis: report of 2 cases. (15714427)
2005
33
Rhabdomyolysis in patients with west nile encephalitis and meningitis. (16187894)
2005
34
Differential diagnosis of West Nile encephalitis. (15353960)
2004
35
West Nile encephalitis and myelitis. (15167070)
2004
36
Listeria monocytogenes encephalitis mimicking West Nile encephalitis. (14983142)
2004
37
Central diabetes insipidus complicating West Nile encephalitis. (15034844)
2004
38
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World. (15550172)
2004
39
Prognostic importance of lymphopenia in West Nile encephalitis. (15501215)
2004
40
Serum ferritin levels in West Nile encephalitis. (14759247)
2004
41
An occipital lobe epileptogenic focus in a patient with West Nile encephalitis. (14748771)
2004
42
West Nile encephalitis presenting as a stroke. (12572565)
2003
43
Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. (14583143)
2003
44
Infection and injury of neurons by West Nile encephalitis virus. (14645577)
2003
45
Muscle weakness in West Nile encephalitis is due to destruction of motor neurons. (12827621)
2003
46
B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. (12551996)
2003
47
Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disorders. (12766856)
2003
48
West Nile encephalitis in Massachusetts. (11919319)
2002
49
Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. (11927020)
2002
50
Print media coverage of risk-risk tradeoffs associated with West Nile encephalitis and pesticide spraying. (12468668)
2002

Variations for West Nile Encephalitis

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Expression for genes affiliated with West Nile Encephalitis

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Search GEO for disease gene expression data for West Nile Encephalitis.

Pathways for genes affiliated with West Nile Encephalitis

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Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5OAS1, OAS3
2
Show member pathways
8.9BST2, OAS1, OAS3
3
Show member pathways
8.9BST2, OAS1, OAS3

GO Terms for genes affiliated with West Nile Encephalitis

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Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:006033310.1OAS1, OAS3
2positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.9BST2, MID2
3defense response to virusGO:00516079.6BST2, OAS1, OAS3
4negative regulation of viral genome replicationGO:00450719.5BST2, OAS1, OAS3
5response to virusGO:00096159.4BST2, OAS1, OAS3
6innate immune responseGO:00450879.0BST2, MID2, OAS1, OAS3
7type I interferon signaling pathwayGO:00603378.9BST2, OAS1, OAS3

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
12-5-oligoadenylate synthetase activityGO:000173010.1OAS1, OAS3
2double-stranded RNA bindingGO:000372510.0OAS1, OAS3
3nucleotidyltransferase activityGO:00167799.5OAS1, OAS3

Sources for West Nile Encephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet