MCID: WST004
MIFTS: 39

West Nile Encephalitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for West Nile Encephalitis

Aliases & Descriptions for West Nile Encephalitis:

Name: West Nile Encephalitis 12 50 14
West Nile Fever 42 69
West Nile Fever with Encephalitis 12
Encephalitis, West Nile Fever 69
West Nile Fever Encephalitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2365
ICD10 33 A92.31
ICD9CM 35 066.41
MeSH 42 D014901
SNOMED-CT 64 392662004
UMLS 69 C0751583

Summaries for West Nile Encephalitis

NIH Rare Diseases : 50 west nile encephalitis is a form of west nile virus that affects the neurological system. signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures, paralysis, or coma. west nile virus is generally spread to humans by infected mosquitos. west nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system. although west nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer, diabetes, hypertension, and kidney disease have the highest risk of developing the condition. treatment is supportive and hospitalization may be required to address the associated symptoms. recovery may take several weeks or months and some of the neurologic effects may be permanent. last updated: 10/14/2016

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to west nile virus and kunjin encephalitis, and has symptoms including high fever, headache and neck stiffness. An important gene associated with West Nile Encephalitis is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Interferon gamma signaling and Hepatitis C. The drugs Ribavirin and Glycine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and b cells.

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in brain, has material basis in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

Related Diseases for West Nile Encephalitis

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
id Related Disease Score Top Affiliating Genes
1 west nile virus 11.5
2 kunjin encephalitis 11.2
3 west nile fever 11.2
4 encephalitis 10.7
5 argentine hemorrhagic fever 10.0 OAS1 OAS3
6 neuronitis 10.0
7 meningitis 10.0
8 methylmalonic aciduria and homocystinuria, cblj type 9.9 OAS1 OAS3
9 japanese encephalitis 9.8
10 status epilepticus 9.8
11 myelitis 9.8
12 pneumonia 9.8
13 lymphopenia 9.8
14 diabetes insipidus 9.8
15 opsoclonus-myoclonus syndrome 9.8
16 myoclonus 9.8
17 malaria 9.8
18 mineral metabolism disease 9.7 BST2 OAS1 OAS3
19 hereditary elliptocytosis 9.2 BST2 INVS MID2 OAS1 OAS3

Graphical network of the top 20 diseases related to West Nile Encephalitis:



Diseases related to West Nile Encephalitis

Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

12 (show all 12)
  • high fever
  • headache
  • neck stiffness
  • stupor
  • disorientation
  • coma
  • tremors
  • convulsions
  • muscle weakness
  • vision loss
  • numbness
  • paralysis

Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
3 Anti-Infective Agents Phase 2
4 Antimetabolites Phase 2
5 Antiviral Agents Phase 2
6 Vaccines Phase 2,Phase 1
7 Pharmaceutical Solutions Phase 1, Phase 2
8 Immunoglobulin G Phase 1, Phase 2
9 Immunoglobulins Phase 1, Phase 2
10 gamma-Globulins Phase 1, Phase 2
11 Immunoglobulins, Intravenous Phase 1, Phase 2
12 Rho(D) Immune Globulin Phase 1, Phase 2
13 Antibodies Phase 1, Phase 2
14 Antibodies, Monoclonal Phase 2
15
nivolumab Approved 946414-94-4

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2
2 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2
3 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2
4 Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis Completed NCT01856205 Phase 2
5 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
6 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
7 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
8 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
9 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
10 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
11 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1
12 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1
13 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1
14 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1
15 Natural History of West Nile Virus Infection Completed NCT00069303
16 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
17 Pattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology Practice Recruiting NCT02847728
18 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

Anatomical Context for West Nile Encephalitis

MalaCards organs/tissues related to West Nile Encephalitis:

39
Brain, Kidney, B Cells, T Cells, Occipital Lobe

The Foundational Model of Anatomy Ontology organs/tissues related to West Nile Encephalitis:

18
Brain

Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

(show top 50) (show all 63)
id Title Authors Year
1
Outcomes of West Nile encephalitis patients after one year of West Nile encephalitis outbreak in Kerala, India: A follow-up study. ( 27061922 )
2016
2
A Case of West Nile Encephalitis That Develops into a Disease of Deep White Matter on MRI over a Two-Week Span. ( 27703823 )
2016
3
West Nile Encephalitis and Its Characteristics in Childhood. ( 26199702 )
2015
4
The first reported case of West Nile encephalitis in Korea. ( 25729260 )
2015
5
Manifestation of West Nile Encephalitis in Infancy. ( 26501475 )
2015
6
Three Cases of West Nile Encephalitis over an Eight-Day Period at a Downtown Los Angeles Community Hospital. ( 26106493 )
2015
7
Emergence of Equine West Nile Encephalitis in Central Macedonia, Greece, 2010. ( 25660661 )
2015
8
C-65Neurocognitive Rehabilitation of a West Nile Encephalitis Survivor. ( 25176908 )
2014
9
West Nile encephalitis outbreak in Kerala, India, 2011. ( 24985196 )
2014
10
Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report. ( 24968889 )
2014
11
The 2012 West Nile encephalitis epidemic in Dallas, Texas. ( 23860988 )
2013
12
An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. ( 23864620 )
2013
13
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? ( 23427877 )
2013
14
Locally acquired West Nile encephalitis. ( 21865003 )
2012
15
IL-22 signaling contributes to West Nile encephalitis pathogenesis. ( 22952908 )
2012
16
West Nile encephalitis presenting with severe persistent chills mimicking malaria. ( 22297291 )
2011
17
OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses. ( 20479874 )
2010
18
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. ( 20660705 )
2010
19
Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis. ( 20509624 )
2010
20
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. ( 19200759 )
2009
21
The host immunologic response to West Nile encephalitis virus. ( 19273254 )
2009
22
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. ( 19141700 )
2009
23
Rhabdomyolysis in a patient with West Nile encephalitis and flaccid paralysis. ( 18488686 )
2008
24
The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus. ( 18339459 )
2008
25
Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population. ( 18453596 )
2008
26
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. ( 17630998 )
2007
27
Efficacy and durability of a recombinant subunit West Nile vaccine candidate in protecting hamsters from West Nile encephalitis. ( 17067727 )
2007
28
Opsoclonus persisting during sleep in West Nile encephalitis. ( 16966514 )
2006
29
West Nile encephalitis mimicking herpes encephalitis. ( 16814089 )
2006
30
West Nile encephalitis relapse presenting with abducens and facial nerve palsies. ( 16750946 )
2006
31
Potentiation of West Nile encephalitis by mosquito feeding. ( 16553552 )
2006
32
Use of interferon-alpha in patients with West Nile encephalitis: report of 2 cases. ( 15714427 )
2005
33
Rhabdomyolysis in patients with west nile encephalitis and meningitis. ( 16187894 )
2005
34
Differential diagnosis of West Nile encephalitis. ( 15353960 )
2004
35
West Nile encephalitis and myelitis. ( 15167070 )
2004
36
Listeria monocytogenes encephalitis mimicking West Nile encephalitis. ( 14983142 )
2004
37
Central diabetes insipidus complicating West Nile encephalitis. ( 15034844 )
2004
38
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World. ( 15550172 )
2004
39
Prognostic importance of lymphopenia in West Nile encephalitis. ( 15501215 )
2004
40
Serum ferritin levels in West Nile encephalitis. ( 14759247 )
2004
41
An occipital lobe epileptogenic focus in a patient with West Nile encephalitis. ( 14748771 )
2004
42
West Nile encephalitis presenting as a stroke. ( 12572565 )
2003
43
Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. ( 14583143 )
2003
44
Infection and injury of neurons by West Nile encephalitis virus. ( 14645577 )
2003
45
Muscle weakness in West Nile encephalitis is due to destruction of motor neurons. ( 12827621 )
2003
46
B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. ( 12551996 )
2003
47
Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disorders. ( 12766856 )
2003
48
West Nile encephalitis in Massachusetts. ( 11919319 )
2002
49
Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. ( 11927020 )
2002
50
Print media coverage of risk-risk tradeoffs associated with West Nile encephalitis and pesticide spraying. ( 12468668 )
2002

Variations for West Nile Encephalitis

Expression for West Nile Encephalitis

Search GEO for disease gene expression data for West Nile Encephalitis.

Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.62 BST2 OAS1 OAS3
2 11.27 OAS1 OAS3
3
Show member pathways
11.01 BST2 OAS1 OAS3

GO Terms for West Nile Encephalitis

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.5 BST2 OAS1 OAS3
2 innate immune response GO:0045087 9.46 BST2 MID2 OAS1 OAS3
3 response to virus GO:0009615 9.43 BST2 OAS1 OAS3
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.4 BST2 MID2
5 interferon-gamma-mediated signaling pathway GO:0060333 9.37 OAS1 OAS3
6 type I interferon signaling pathway GO:0060337 9.13 BST2 OAS1 OAS3
7 negative regulation of viral genome replication GO:0045071 8.8 BST2 OAS1 OAS3

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleotidyltransferase activity GO:0016779 9.16 OAS1 OAS3
2 double-stranded RNA binding GO:0003725 8.96 OAS1 OAS3
3 2-5-oligoadenylate synthetase activity GO:0001730 8.62 OAS1 OAS3

Sources for West Nile Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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