Aliases & Classifications for West Nile Fever

MalaCards integrated aliases for West Nile Fever:

Name: West Nile Fever 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2366
ICD10 32 A92.3 A92.30
ICD9CM 34 066.4 066.40
MeSH 41 D014901
SNOMED-CT 64 12381007 417093003
UMLS 69 C0043124

Summaries for West Nile Fever

Disease Ontology : 12 A viral infectious disease that results_in infection, has material basis in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom body ache, has symptom nausea, has symptom maculopapular rash and has symptom vomiting.

MalaCards based summary : West Nile Fever is related to west nile virus and west nile encephalitis, and has symptoms including fever, sore throat and headache. An important gene associated with West Nile Fever is RPS29 (Ribosomal Protein S29). The drugs Glycine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for West Nile Fever

Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 west nile virus 11.9
2 west nile encephalitis 11.7
3 encephalitis 10.3
4 rift valley fever 10.0
5 coccidioidomycosis 10.0
6 louping ill 10.0 CD40LG STAB2
7 murray valley encephalitis 9.9 CD40LG STAB2
8 stiff-person syndrome 9.9
9 chikungunya 9.9
10 hyperekplexia 1 9.9
11 japanese encephalitis 9.9
12 acute pancreatitis 9.9
13 newcastle disease 9.9
14 myelitis 9.9
15 pancreatitis 9.9
16 tremor 9.9
17 mite infestation 9.8 DEFA1 DEFA3
18 bell's palsy 9.8 DEFA1 DEFA3
19 la crosse encephalitis 9.8 CD40LG STAB2
20 multidrug-resistant tuberculosis 9.7 DEFA1 DEFA3
21 dirofilariasis 9.6 CD40LG STAB2

Graphical network of the top 20 diseases related to West Nile Fever:



Diseases related to West Nile Fever

Symptoms & Phenotypes for West Nile Fever

Symptoms:

12
  • fever
  • sore throat
  • headache
  • body ache
  • nausea
  • maculopapular rash
  • vomiting

GenomeRNAi Phenotypes related to West Nile Fever according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.47 RPS29
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.47 RPS29
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 DEFA1 DEFA3 RPS29
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.47 DEFA1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.47 RPS29
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.47 RPS29
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.47 DEFA3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 DEFA1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.47 DEFA1 DEFA3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.47 DEFA3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.47 DEFA1

Drugs & Therapeutics for West Nile Fever

Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Vaccines Phase 2,Phase 1
3 Antibodies Phase 2,Phase 1
4 Immunoglobulins Phase 2,Phase 1
5 Pharmaceutical Solutions Phase 2,Phase 1
6 gamma-Globulins Phase 1, Phase 2
7 Immunoglobulins, Intravenous Phase 1, Phase 2
8 Rho(D) Immune Globulin Phase 1, Phase 2
9 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
2 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
3 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
4 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
5 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
6 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
7 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
8 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
9 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
10 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
11 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
12 Natural History of West Nile Virus Infection Completed NCT00069303
13 West Nile Virus Natural History Completed NCT00138463
14 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
15 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Fever

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for West Nile Fever

Anatomical Context for West Nile Fever

MalaCards organs/tissues related to West Nile Fever:

38
Lymph Node

Publications for West Nile Fever

Articles related to West Nile Fever:

(show top 50) (show all 65)
# Title Authors Year
1
Improved reliability of serological tools for the diagnosis of West Nile fever in horses within Europe. ( 28915240 )
2017
2
Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry. ( 27342050 )
2016
3
Outbreaks of West Nile fever in France. ( 26405120 )
2015
4
ECDC publishes new interactive online tool: West Nile fever maps for 2015. ( 26062647 )
2015
5
WEST NILE FEVER IN BRAZIL: SPORADIC CASE, SILENT ENDEMIC DISEASE OR EPIDEMIC IN ITS INITIAL STAGES? ( 26200972 )
2015
6
Environmental predictors of West Nile fever risk in Europe. ( 24986363 )
2014
7
West Nile fever in Israel: The reemergence of an endemic disease. ( 24183889 )
2014
8
Human and entomological surveillance of West Nile fever, dengue and chikungunya in Veneto Region, Italy, 2010-2012. ( 24499011 )
2014
9
Clinical Sentinel Surveillance of Equine West Nile Fever, Spain. ( 24899369 )
2014
10
Can horses be clinically screened for West Nile Fever? ( 23292842 )
2013
11
Environmental drivers of West Nile fever epidemiology in Europe and Western Asia--a review. ( 23939389 )
2013
12
Mapping the Serological Prevalence Rate of West Nile fever in Equids, Tunisia. ( 23906318 )
2013
13
Permissive summer temperatures of the 2010 European West Nile fever upsurge. ( 23431374 )
2013
14
Animal viral diseases and global change: bluetongue and West Nile fever as paradigms. ( 22707955 )
2012
15
Clinical diagnosis of West Nile Fever in Equids by classification and regression tree (CART) analysis and comparative study of clinical appearance in three European countries. ( 21208395 )
2011
16
West Nile fever outbreak in horses and humans, Spain, 2010. ( 22172565 )
2011
17
Temporal distribution and spatial pattern of abundance of the Rift Valley fever and West Nile fever vectors in Barkedji, Senegal. ( 22129415 )
2011
18
Primary causes of death in reported cases of fatal West Nile Fever, United States, 2002-2006. ( 20687860 )
2011
19
Evaluation of the efficiency of bird-baited traps for sampling potential West Nile fever mosquito vectors (Diptera: Culicidae) in Senegal. ( 20597441 )
2010
20
West Nile fever characteristics among viremic persons identified through blood donor screening. ( 20874087 )
2010
21
Differential West Nile fever ascertainment in the United States: a multilevel analysis. ( 20889867 )
2010
22
Where is West Nile fever? Lessons learnt from recent human cases in northern Italy. ( 19317987 )
2009
23
West Nile fever in a patient in Romania, August 2008: case report. ( 18822244 )
2008
24
Persistent neurobehavioral signs and symptoms following West Nile fever. ( 18305310 )
2008
25
Influence of warming tendency on Culex pipiens population abundance and on the probability of West Nile fever outbreaks (Israeli Case Study: 2001-2005). ( 18648796 )
2008
26
Mosquito vectors of West Nile Fever in Israel. ( 18826039 )
2008
27
West Nile viremic blood donors and risk factors for subsequent West Nile fever. ( 17979539 )
2007
28
Maculopapular rash and tremor are associated with West Nile fever and neurological syndromes. ( 17435190 )
2007
29
Serological assessment of West Nile fever virus activity in the pastoral system of Ferlo, Senegal. ( 17135514 )
2006
30
Post-epidemic serosurvey of West Nile fever in Israel. ( 16362810 )
2005
31
Rehabilitation of West Nile Fever (WNF) encephalitis in elderly. ( 15911034 )
2005
32
Mass media-induced availability bias in the clinical suspicion of West Nile fever. ( 14757629 )
2004
33
Summaries for patients. Clinical characteristics and consequences of West Nile Fever. ( 15353444 )
2004
34
Epidemiological processes involved in the emergence of vector-borne diseases: West Nile fever, Rift Valley fever, Japanese encephalitis and Crimean-Congo haemorrhagic fever. ( 15702718 )
2004
35
Stiff-person syndrome following West Nile fever. ( 15210535 )
2004
36
Clinical characteristics and functional outcomes of West Nile Fever. ( 15353427 )
2004
37
Morphofunctional characteristics of antigen-presenting cells in lymph node in mice with experimental West Nile fever. ( 12802405 )
2003
38
Death from the Nile crosses the Atlantic: the West Nile Fever story. ( 14723356 )
2003
39
West Nile fever: lessons from the 2002 season. ( 12779134 )
2003
40
Outcome of West Nile fever in older adults. ( 12410904 )
2002
41
West Nile fever: here to stay and spreading. ( 11405618 )
2001
42
Use of live and inactivated vaccines in the control of West Nile fever in domestic geese. ( 11797782 )
2001
43
Clinical characteristics of the West Nile fever outbreak, Israel, 2000. ( 11585531 )
2001
44
West Nile fever outbreak, Israel, 2000: epidemiologic aspects. ( 11585533 )
2001
45
Comparative symptomatology of West Nile fever. ( 11498205 )
2001
46
West Nile fever in the United States. ( 12876824 )
2000
47
West Nile fever heads north. ( 11033722 )
2000
48
West Nile fever in New York City. ( 10763405 )
2000
49
Rhombencephalitis caused by West Nile fever virus. ( 10891935 )
2000
50
An outbreak of West Nile fever among migrants in Kisangani, Democratic Republic of Congo. ( 10674664 )
1999

Variations for West Nile Fever

Expression for West Nile Fever

Search GEO for disease gene expression data for West Nile Fever.

Pathways for West Nile Fever

GO Terms for West Nile Fever

Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.96 DEFA1 DEFA3
2 azurophil granule lumen GO:0035578 8.62 DEFA1 DEFA3

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.49 DEFA1 DEFA3
2 defense response GO:0006952 9.48 DEFA1 DEFA3
3 antimicrobial humoral response GO:0019730 9.46 DEFA1 DEFA3
4 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.43 DEFA1 DEFA3
5 defense response to bacterium GO:0042742 9.43 DEFA1 DEFA3 STAB2
6 killing of cells of other organism GO:0031640 9.4 DEFA1 DEFA3
7 antibacterial humoral response GO:0019731 9.37 DEFA1 DEFA3
8 defense response to fungus GO:0050832 9.32 DEFA1 DEFA3
9 innate immune response in mucosa GO:0002227 9.16 DEFA1 DEFA3
10 intracellular estrogen receptor signaling pathway GO:0030520 8.96 DEFA1 DEFA3
11 defense response to Gram-positive bacterium GO:0050830 8.8 DEFA1 DEFA3 STAB2

Sources for West Nile Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....