Aliases & Classifications for West Nile Fever

Aliases & Descriptions for West Nile Fever:

Name: West Nile Fever 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2366
ICD10 33 A92.3 A92.30
ICD9CM 35 066.4 066.40
MeSH 42 D014901
SNOMED-CT 64 12381007 417093003
UMLS 69 C0043124

Summaries for West Nile Fever

Disease Ontology : 12 A viral infectious disease that results_in infection, has material basis in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom body ache, has symptom nausea, has symptom maculopapular rash and has symptom vomiting.

MalaCards based summary : West Nile Fever is related to west nile virus and west nile encephalitis, and has symptoms including fever, sore throat and headache. An important gene associated with West Nile Fever is RPS29 (Ribosomal Protein S29), and among its related pathways/superpathways is Defensins. The drugs Aspirin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and lymph node, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 71 West Nile fever is a mosquito-borne infection by the West Nile virus. Approximately 80% of West Nile... more...

Related Diseases for West Nile Fever

Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
id Related Disease Score Top Affiliating Genes
1 west nile virus 11.7
2 west nile encephalitis 11.5
3 encephalitis 10.2
4 mumps 10.0 CD40LG STAB2
5 rift valley fever 9.9
6 st. louis encephalitis 9.9 CD40LG STAB2
7 voyeurism 9.9 CD40LG STAB2
8 benign mediastinal neurilemmoma 9.9 DEFA1 DEFA3
9 osmotic diarrhea 9.8 CD40LG STAB2
10 sarcomatoid transitional cell carcinoma 9.8 DEFA1 DEFA3
11 chikungunya 9.8
12 japanese encephalitis 9.8
13 acute pancreatitis 9.8
14 newcastle disease 9.8
15 myelitis 9.8
16 pancreatitis 9.8
17 tremor 9.8
18 stiff-person syndrome 9.8
19 trichuriasis 9.7 CD40LG DEFA1 DEFA3
20 relapsing-remitting multiple sclerosis 9.3 CD40LG DEFA1 DEFA3 RPS29 STAB2

Graphical network of the top 20 diseases related to West Nile Fever:



Diseases related to West Nile Fever

Symptoms & Phenotypes for West Nile Fever

Symptoms:

12
  • fever
  • sore throat
  • headache
  • body ache
  • nausea
  • maculopapular rash
  • vomiting

GenomeRNAi Phenotypes related to West Nile Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.47 RPS29
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.47 RPS29
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 DEFA1 DEFA3 RPS29
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.47 DEFA1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.47 RPS29
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.47 RPS29
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.47 DEFA3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 DEFA1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.47 DEFA1 DEFA3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.47 DEFA3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.47 DEFA1

Drugs & Therapeutics for West Nile Fever

Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
4
Vidarabine Approved Phase 3 24356-66-9 32326 21704
5
rituximab Approved Phase 3 174722-31-7 10201696
6 Anti-Infective Agents Phase 3,Phase 2
7 Antimetabolites Phase 3,Phase 2
8 Antiviral Agents Phase 3,Phase 2
9 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
10 Vaccines Phase 3,Phase 2,Phase 1
11 Immunoglobulins Phase 3,Phase 2,Phase 1
12 Antibodies Phase 3,Phase 2,Phase 1
13 Analgesics Phase 3
14 Cyclooxygenase Inhibitors Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Platelet Aggregation Inhibitors Phase 3
18 Fibrinolytic Agents Phase 3
19 Anti-Inflammatory Agents Phase 3
20 Anti-Inflammatory Agents, Non-Steroidal Phase 3
21 Antipyretics Phase 3
22 Antirheumatic Agents Phase 3
23 Alkylating Agents Phase 3
24 Vidarabine Phosphate Phase 3
25 Antibodies, Monoclonal Phase 3,Phase 2
26 Immunosuppressive Agents Phase 3
27 Antimetabolites, Antineoplastic Phase 3
28 Antineoplastic Agents, Alkylating Phase 3
29
Ribavirin Approved Phase 2 36791-04-5 37542
30
Dabrafenib Approved Phase 2 44462760 44516822
31
Trametinib Approved Phase 2 871700-17-3 11707110
32
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
33 Pharmaceutical Solutions Phase 2,Phase 1
34 Immunoglobulin G Phase 1, Phase 2
35 gamma-Globulins Phase 1, Phase 2
36 Immunoglobulins, Intravenous Phase 1, Phase 2
37 Rho(D) Immune Globulin Phase 1, Phase 2
38 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
2 Aspirin in Preventing Recurrence of Cancer in Patients With Node Positive HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy Recruiting NCT02927249 Phase 3
3 Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT02048813 Phase 3
4 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2
5 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
6 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
7 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2
8 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2
9 Immunogenicity and Safety of GlaxoSmithKline Biologicals' MMRV Vaccine vs. ProQuad® in Children 12-14 Months of Age Completed NCT00578175 Phase 2
10 Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAF Mutant Melanoma That Cannot Be Removed by Surgery Recruiting NCT02196181 Phase 2
11 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
12 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1
13 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
14 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
15 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1
16 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1
17 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1
18 Natural History of West Nile Virus Infection Completed NCT00069303
19 West Nile Virus Natural History Completed NCT00138463
20 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166
21 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
22 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Fever

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for West Nile Fever

Anatomical Context for West Nile Fever

MalaCards organs/tissues related to West Nile Fever:

39
Brain, Spinal Cord, Lymph Node

Publications for West Nile Fever

Articles related to West Nile Fever:

(show top 50) (show all 64)
id Title Authors Year
1
Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry. ( 27342050 )
2016
2
WEST NILE FEVER IN BRAZIL: SPORADIC CASE, SILENT ENDEMIC DISEASE OR EPIDEMIC IN ITS INITIAL STAGES? ( 26200972 )
2015
3
Outbreaks of West Nile fever in France. ( 26405120 )
2015
4
ECDC publishes new interactive online tool: West Nile fever maps for 2015. ( 26062647 )
2015
5
Human and entomological surveillance of West Nile fever, dengue and chikungunya in Veneto Region, Italy, 2010-2012. ( 24499011 )
2014
6
Clinical Sentinel Surveillance of Equine West Nile Fever, Spain. ( 24899369 )
2014
7
West Nile fever in Israel: The reemergence of an endemic disease. ( 24183889 )
2014
8
Environmental predictors of West Nile fever risk in Europe. ( 24986363 )
2014
9
Permissive summer temperatures of the 2010 European West Nile fever upsurge. ( 23431374 )
2013
10
Can horses be clinically screened for West Nile Fever? ( 23292842 )
2013
11
Environmental drivers of West Nile fever epidemiology in Europe and Western Asia--a review. ( 23939389 )
2013
12
Mapping the Serological Prevalence Rate of West Nile fever in Equids, Tunisia. ( 23906318 )
2013
13
Animal viral diseases and global change: bluetongue and West Nile fever as paradigms. ( 22707955 )
2012
14
West Nile fever outbreak in horses and humans, Spain, 2010. ( 22172565 )
2011
15
Primary causes of death in reported cases of fatal West Nile Fever, United States, 2002-2006. ( 20687860 )
2011
16
Temporal distribution and spatial pattern of abundance of the Rift Valley fever and West Nile fever vectors in Barkedji, Senegal. ( 22129415 )
2011
17
Clinical diagnosis of West Nile Fever in Equids by classification and regression tree (CART) analysis and comparative study of clinical appearance in three European countries. ( 21208395 )
2011
18
Evaluation of the efficiency of bird-baited traps for sampling potential West Nile fever mosquito vectors (Diptera: Culicidae) in Senegal. ( 20597441 )
2010
19
Differential West Nile fever ascertainment in the United States: a multilevel analysis. ( 20889867 )
2010
20
West Nile fever characteristics among viremic persons identified through blood donor screening. ( 20874087 )
2010
21
Where is West Nile fever? Lessons learnt from recent human cases in northern Italy. ( 19317987 )
2009
22
Persistent neurobehavioral signs and symptoms following West Nile fever. ( 18305310 )
2008
23
West Nile fever in a patient in Romania, August 2008: case report. ( 18822244 )
2008
24
Mosquito vectors of West Nile Fever in Israel. ( 18826039 )
2008
25
Influence of warming tendency on Culex pipiens population abundance and on the probability of West Nile fever outbreaks (Israeli Case Study: 2001-2005). ( 18648796 )
2008
26
West Nile viremic blood donors and risk factors for subsequent West Nile fever. ( 17979539 )
2007
27
Maculopapular rash and tremor are associated with West Nile fever and neurological syndromes. ( 17435190 )
2007
28
Serological assessment of West Nile fever virus activity in the pastoral system of Ferlo, Senegal. ( 17135514 )
2006
29
Post-epidemic serosurvey of West Nile fever in Israel. ( 16362810 )
2005
30
Rehabilitation of West Nile Fever (WNF) encephalitis in elderly. ( 15911034 )
2005
31
Mass media-induced availability bias in the clinical suspicion of West Nile fever. ( 14757629 )
2004
32
Epidemiological processes involved in the emergence of vector-borne diseases: West Nile fever, Rift Valley fever, Japanese encephalitis and Crimean-Congo haemorrhagic fever. ( 15702718 )
2004
33
Summaries for patients. Clinical characteristics and consequences of West Nile Fever. ( 15353444 )
2004
34
Stiff-person syndrome following West Nile fever. ( 15210535 )
2004
35
Clinical characteristics and functional outcomes of West Nile Fever. ( 15353427 )
2004
36
Morphofunctional characteristics of antigen-presenting cells in lymph node in mice with experimental West Nile fever. ( 12802405 )
2003
37
West Nile fever: lessons from the 2002 season. ( 12779134 )
2003
38
Death from the Nile crosses the Atlantic: the West Nile Fever story. ( 14723356 )
2003
39
Outcome of West Nile fever in older adults. ( 12410904 )
2002
40
West Nile fever outbreak, Israel, 2000: epidemiologic aspects. ( 11585533 )
2001
41
Comparative symptomatology of West Nile fever. ( 11498205 )
2001
42
West Nile fever: here to stay and spreading. ( 11405618 )
2001
43
Use of live and inactivated vaccines in the control of West Nile fever in domestic geese. ( 11797782 )
2001
44
Clinical characteristics of the West Nile fever outbreak, Israel, 2000. ( 11585531 )
2001
45
West Nile fever in the United States. ( 12876824 )
2000
46
Rhombencephalitis caused by West Nile fever virus. ( 10891935 )
2000
47
West Nile fever heads north. ( 11033722 )
2000
48
West Nile fever in New York City. ( 10763405 )
2000
49
An outbreak of West Nile fever among migrants in Kisangani, Democratic Republic of Congo. ( 10674664 )
1999
50
West Nile fever in Czechland. ( 10458974 )
1999

Variations for West Nile Fever

Expression for West Nile Fever

Search GEO for disease gene expression data for West Nile Fever.

Pathways for West Nile Fever

Pathways related to West Nile Fever according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 DEFA1 DEFA3

GO Terms for West Nile Fever

Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.96 DEFA1 DEFA3
2 azurophil granule lumen GO:0035578 8.62 DEFA1 DEFA3

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.48 DEFA1 DEFA3
2 defense response GO:0006952 9.46 DEFA1 DEFA3
3 defense response to Gram-positive bacterium GO:0050830 9.43 DEFA1 DEFA3
4 antimicrobial humoral response GO:0019730 9.4 DEFA1 DEFA3
5 antibacterial humoral response GO:0019731 9.37 DEFA1 DEFA3
6 killing of cells of other organism GO:0031640 9.32 DEFA1 DEFA3
7 defense response to fungus GO:0050832 9.26 DEFA1 DEFA3
8 innate immune response in mucosa GO:0002227 9.16 DEFA1 DEFA3
9 intracellular estrogen receptor signaling pathway GO:0030520 8.96 DEFA1 DEFA3
10 defense response to bacterium GO:0042742 8.8 DEFA1 DEFA3 STAB2

Sources for West Nile Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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