MCID: WST005
MIFTS: 40

West Nile Virus malady

Genetic diseases, Rare diseases categories

Summaries for West Nile Virus

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MedlinePlus:32 West nile virus (wnv) is an infectious disease that first appeared in the united states in 1999. infected mosquitoes spread the virus that causes it. people who get wnv usually have no symptoms or mild symptoms. the symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. they can last a few days to several weeks, and usually go away on their own. if west nile virus enters the brain, however, it can be life-threatening. it may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. a physical exam, health history and laboratory tests can diagnose it. older people and those with weakened immune systems are most at risk. there are no specific vaccines or treatments for human wnv disease. the best way to avoid wnv is to prevent mosquito bites: use insect repellent get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels stay indoors between dusk and dawn, when mosquitoes are most active use screens on windows to keep mosquitoes out nih: national institute of allergy and infectious diseases

MalaCards based summary: West Nile Virus, also known as west nile virus, susceptibility to, is related to encephalitis and rift valley fever. An important gene associated with West Nile Virus is CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene)), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and NF-kappaB Signaling. The compounds ribavirin and polyinosinic-polycytidylic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord.

OMIM:45 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle... (610379) more...

Wikipedia:63 West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the... more...

Aliases & Classifications for West Nile Virus

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West Nile Virus, Aliases & Descriptions:

Name: West Nile Virus 45 41 32
West Nile Virus, Susceptibility to 10
 
West Nile Viral Infection 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


External Ids:

OMIM45 610379

Related Diseases for West Nile Virus

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Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to west nile virus

Symptoms for West Nile Virus

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Clinical features from OMIM:

610379

Drugs & Therapeutics for West Nile Virus

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Drug clinical trials:

Search ClinicalTrials for West Nile Virus

Search NIH Clinical Center for West Nile Virus

Genetic Tests for West Nile Virus

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Anatomical Context for West Nile Virus

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MalaCards organs/tissues related to West Nile Virus:

31
Brain, Testes, Spinal cord, Skin, T cells, B cells, Kidney, Pancreas, Salivary gland, Endothelial, Thalamus

Animal Models for West Nile Virus or affiliated genes

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Publications for West Nile Virus

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Articles related to West Nile Virus:

(show top 50)    (show all 661)
idTitleAuthorsYear
1
Prevalence of West Nile virus in Mashhad, Iran: A population-based study. (25902161)
2015
2
Implementation of a sampling strategy to detect West Nile virus in oral and cloacal samples in live song birds. (25863262)
2015
3
Understanding West Nile virus ecology in Europe: Culex pipiens host feeding preference in a hotspot of virus emergence. (25888754)
2015
4
Update on West Nile virus in Italy. (25350968)
2014
5
Allele-specific qRT-PCR demonstrates superior detection of single nucleotide polymorphisms as genetic markers for West Nile virus compared to LuminexAr and quantitative sequencing. (24121135)
2014
6
Variation in adult longevity of Culex pipiens f. pipiens, vector of the West Nile Virus. (25284257)
2014
7
Host group formation decreases exposure to vector-borne disease: a field experiment in a 'hotspot' of West Nile virus transmission. (25339722)
2014
8
Genome sequencing of West Nile Virus from human cases in Greece, 2012. (24064795)
2013
9
Complete genome sequence of west nile virus isolated from alappuzha district, kerala, India. (23682140)
2013
10
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. (24333681)
2013
11
West Nile virus infection rates and avian serology in east-central Illinois. (23923325)
2013
12
An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein. (23740481)
2013
13
Molecular detection and isolation of West Nile virus from a human case in northern Greece, 2013. (25356324)
2013
14
Small molecule inhibitors of West Nile virus. (23636899)
2013
15
Pathogenesis of West Nile virus lineage 1 and 2 in experimentally infected large falcons. (22909991)
2013
16
Equine seroprevalence rates as an additional indicator for a more accurate risk assessment of the West Nile virus transmission. (24308242)
2013
17
Preclinical and clinical development of a YFV 17 D-based chimeric vaccine against West Nile virus. (24351795)
2013
18
West Nile virus infection. (23897943)
2013
19
Arenavirus and West Nile virus in solid organ transplantation. (23465029)
2013
20
West Nile virus drug discovery. (24300672)
2013
21
West Nile Virus Infection in the Immunocompromised Patient. (24234656)
2013
22
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? (23427877)
2013
23
West Nile virus: an infectious viral agent to the central nervous system. (23692938)
2013
24
Emergence and co-infections of West Nile virus and Toscana virus in Eastern Thrace, Turkey. (23910388)
2013
25
Integrins modulate the infection efficiency of West Nile virus into cells. (23658209)
2013
26
Serologic survey of West Nile virus in horses from Central-West, Northeast and Southeast Brazil. (24037110)
2013
27
West Nile virus genome with glycosylated envelope protein and deletion of alpha helices 1, 2, and 4 in the capsid protein is noninfectious and efficiently secretes subviral particles. (24049184)
2013
28
Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease. (23307694)
2013
29
Regional and seasonal response of a West Nile virus vector to climate change. (24019459)
2013
30
National and regional associations between human West Nile virus incidence and demographic, landscape, and land use conditions in the coterminous United States. (22607071)
2012
31
Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. (22345437)
2012
32
West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals. (23173701)
2012
33
In vitro and in vivo activity of AS101 against West Nile virus (WNV). (22445690)
2012
34
West Nile virus T-cell ligand sequences shared with other flaviviruses: a multitude of variant sequences as potential altered peptide ligands. (22573867)
2012
35
Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. (21940408)
2012
36
Controlling urban epidemics of West Nile virus infection. (22922679)
2012
37
Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus. (22953001)
2012
38
West Nile virus neurologic disease in humans, South Africa, September 2008-may 2009. (23171668)
2012
39
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold. (22632792)
2012
40
The costs of infection and resistance as determinants of West Nile virus susceptibility in Culex mosquitoes. (21975028)
2011
41
A West Nile virus vaccine. (21938496)
2011
42
Host genetic risk factors for West Nile virus infection and disease progression. (21935451)
2011
43
Transcriptional upregulation of SOCS 1 and suppressors of cytokine signaling 3 mRNA in the absence of suppressors of cytokine signaling 2 mRNA after infection with West Nile virus or tick-borne encephalitis virus. (20854017)
2010
44
Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006. (18533445)
2008
45
Differential activation of human monocyte-derived and plasmacytoid dendritic cells by West Nile virus generated in different host cells. (17913823)
2007
46
West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling. (16501100)
2006
47
Serologic evidence of West Nile virus and St. Louis encephalitis virus infections in white-tailed deer (Odocoileus virginianus) from New Jersey, 2001. (15671740)
2004
48
Vitritis and chorioretinitis in a patient with West Nile virus infection. (12583786)
2003
49
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus. (12954067)
2003
50
Isolation of eastern equine encephalitis virus and West Nile virus from crows during increased arbovirus surveillance in Connecticut, 2000. (12164299)
2002

Variations for West Nile Virus

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Clinvar genetic disease variations for West Nile Virus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenic, risk factorrs333GRCh37Chr 3, 46414947: 46414978

Expression for genes affiliated with West Nile Virus

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Search GEO for disease gene expression data for West Nile Virus.

Pathways for genes affiliated with West Nile Virus

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Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4TLR3, DDX58
29.4TLR3, DDX58
39.0OAS1, TLR3, DDX58
4
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0DDX58, TLR3, CREB3L1
5
Show member pathways
8.5DDX58, TLR3, OAS1, MX1
6
Show member pathways
8.4MX1, IFITM3, IFITM2, OAS1
7
Show member pathways
8.0DDX58, OAS1, IFITM2, IFITM3, MX1

Compounds for genes affiliated with West Nile Virus

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Compounds related to West Nile Virus according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1ribavirin43 49 1211.5MX1, CCR5
2polyinosinic-polycytidylic acid439.4TLR3, DDX58
3imiquimod43 59 28 1212.4TLR3, MX1
4cyclic amp43 2410.2CREB3L1, CCR5, MSBP1
52,5-oligoadenylate439.1MX1, OAS1, TLR3
6ifn-alpha439.0TLR3, MX1
7poly(i-c)439.0MX1, TLR3, DDX58
8rantes438.7DDX58, TLR3, CCR5, MX1

GO Terms for genes affiliated with West Nile Virus

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Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1detection of virusGO:00095979.6TLR3, DDX58
2response to interferon-betaGO:00354569.5IFITM3, IFITM2
3negative regulation of viral entry into host cellGO:00465979.5IFITM2, IFITM3
4response to interferon-alphaGO:00354559.4IFITM2, IFITM3
5positive regulation of interferon-beta productionGO:00327289.4DDX58, TLR3
6response to interferon-gammaGO:00343419.4IFITM2, IFITM3
7response to exogenous dsRNAGO:00433309.3TLR3, DDX58
8innate immune responseGO:00450878.9MX1, TLR3, DDX58
9immune responseGO:00069558.7CCR5, IFITM2, IFITM3
10negative regulation of viral genome replicationGO:00450718.7OAS1, IFITM2, IFITM3, MX1
11type I interferon signaling pathwayGO:00603378.7MX1, IFITM3, IFITM2, OAS1
12cytokine-mediated signaling pathwayGO:00192218.6OAS1, IFITM2, IFITM3, MX1
13response to virusGO:00096158.2MX1, IFITM3, IFITM2, OAS1, DDX58
14defense response to virusGO:00516078.0TLR3, OAS1, IFITM2, IFITM3, MX1

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:00037259.0OAS1, TLR3, DDX58

Products for genes affiliated with West Nile Virus

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Sources for West Nile Virus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet