MCID: WST005
MIFTS: 46

West Nile Virus malady

Rare diseases category
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Summaries for West Nile Virus

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MedlinePlus:33 West nile virus (wnv) is an infectious disease that first appeared in the united states in 1999. infected mosquitoes spread the virus that causes it. people who get wnv usually have no symptoms or mild symptoms. the symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. they can last a few days to several weeks, and usually go away on their own. if west nile virus enters the brain, however, it can be life-threatening. it may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. a physical exam, health history and laboratory tests can diagnose it. older people and those with weakened immune systems are most at risk. there are no specific vaccines or treatments for human wnv disease. the best way to avoid wnv is to prevent mosquito bites: use insect repellent get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels stay indoors between dusk and dawn, when mosquitoes are most active use screens on windows to keep mosquitoes out nih: national institute of allergy and infectious diseases

MalaCards based summary: West Nile Virus, also known as west nile virus nos, is related to encephalitis and rift valley fever. An important gene associated with West Nile Virus is CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene)), and among its related pathways are Hepatitis C and Toll-like receptor signaling pathway. The compounds imiquimod and ifn-alpha have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Wikipedia:65 West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the... more...

Description from OMIM:46 610379

Aliases & Classifications for West Nile Virus

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West Nile Virus, Aliases & Descriptions:

Name: West Nile Virus 42 46 33
 
West Nile Virus Nos 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for West Nile Virus

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Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to west nile virus

Symptoms for West Nile Virus

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Clinical features from OMIM:

610379

Drugs & Therapeutics for West Nile Virus

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Drug clinical trials:

Search ClinicalTrials for West Nile Virus

Search NIH Clinical Center for West Nile Virus

Genetic Tests for West Nile Virus

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Anatomical Context for West Nile Virus

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MalaCards organs/tissues related to West Nile Virus:

32
Brain, Testes, Skin, Spinal cord, T cells, B cells, Kidney, Pancreas, Salivary gland, Endothelial, Thalamus

Animal Models for West Nile Virus or affiliated genes

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MGI Mouse Phenotypes related to West Nile Virus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TRD, IFITM1, CCR5, DDX58
2MP:00020068.3DDX58, TLR3, CCR5, TRD
3MP:00053977.6TRD, CREB3L1, IFITM1, CCR5, TLR3, DDX58

Publications for West Nile Virus

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Articles related to West Nile Virus:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Update on West Nile virus in Italy. (25350968)
2014
2
Allele-specific qRT-PCR demonstrates superior detection of single nucleotide polymorphisms as genetic markers for West Nile virus compared to LuminexAr and quantitative sequencing. (24121135)
2014
3
Variation in adult longevity of Culex pipiens f. pipiens, vector of the West Nile Virus. (25284257)
2014
4
Genome sequencing of West Nile Virus from human cases in Greece, 2012. (24064795)
2013
5
Complete genome sequence of west nile virus isolated from alappuzha district, kerala, India. (23682140)
2013
6
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. (24333681)
2013
7
West Nile virus infection rates and avian serology in east-central Illinois. (23923325)
2013
8
An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein. (23740481)
2013
9
Molecular detection and isolation of West Nile virus from a human case in northern Greece, 2013. (25356324)
2013
10
Small molecule inhibitors of West Nile virus. (23636899)
2013
11
Pathogenesis of West Nile virus lineage 1 and 2 in experimentally infected large falcons. (22909991)
2013
12
Equine seroprevalence rates as an additional indicator for a more accurate risk assessment of the West Nile virus transmission. (24308242)
2013
13
Preclinical and clinical development of a YFV 17 D-based chimeric vaccine against West Nile virus. (24351795)
2013
14
West Nile virus infection. (23897943)
2013
15
Arenavirus and West Nile virus in solid organ transplantation. (23465029)
2013
16
West Nile virus drug discovery. (24300672)
2013
17
West Nile Virus Infection in the Immunocompromised Patient. (24234656)
2013
18
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? (23427877)
2013
19
West Nile virus: an infectious viral agent to the central nervous system. (23692938)
2013
20
Emergence and co-infections of West Nile virus and Toscana virus in Eastern Thrace, Turkey. (23910388)
2013
21
Integrins modulate the infection efficiency of West Nile virus into cells. (23658209)
2013
22
Serologic survey of West Nile virus in horses from Central-West, Northeast and Southeast Brazil. (24037110)
2013
23
West Nile virus genome with glycosylated envelope protein and deletion of alpha helices 1, 2, and 4 in the capsid protein is noninfectious and efficiently secretes subviral particles. (24049184)
2013
24
Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease. (23307694)
2013
25
Regional and seasonal response of a West Nile virus vector to climate change. (24019459)
2013
26
Molecular epidemiology and evolution of West Nile virus in North America. (24135819)
2013
27
Development and evaluation of NS1 specific monoclonal antibody based antigen capture ELISA and its implications in clinical diagnosis of West Nile virus infection. (24095027)
2013
28
National and regional associations between human West Nile virus incidence and demographic, landscape, and land use conditions in the coterminous United States. (22607071)
2012
29
Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. (22345437)
2012
30
West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals. (23173701)
2012
31
In vitro and in vivo activity of AS101 against West Nile virus (WNV). (22445690)
2012
32
West Nile virus T-cell ligand sequences shared with other flaviviruses: a multitude of variant sequences as potential altered peptide ligands. (22573867)
2012
33
Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. (21940408)
2012
34
Controlling urban epidemics of West Nile virus infection. (22922679)
2012
35
Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus. (22953001)
2012
36
West Nile virus neurologic disease in humans, South Africa, September 2008-may 2009. (23171668)
2012
37
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold. (22632792)
2012
38
The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile virus. (23094584)
2012
39
Quantification of intrahost bottlenecks of West Nile virus in Culex pipiens mosquitoes using an artificial mutant swarm. (22326536)
2012
40
The costs of infection and resistance as determinants of West Nile virus susceptibility in Culex mosquitoes. (21975028)
2011
41
A West Nile virus vaccine. (21938496)
2011
42
Host genetic risk factors for West Nile virus infection and disease progression. (21935451)
2011
43
Transcriptional upregulation of SOCS 1 and suppressors of cytokine signaling 3 mRNA in the absence of suppressors of cytokine signaling 2 mRNA after infection with West Nile virus or tick-borne encephalitis virus. (20854017)
2010
44
Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006. (18533445)
2008
45
Differential activation of human monocyte-derived and plasmacytoid dendritic cells by West Nile virus generated in different host cells. (17913823)
2007
46
West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling. (16501100)
2006
47
Serologic evidence of West Nile virus and St. Louis encephalitis virus infections in white-tailed deer (Odocoileus virginianus) from New Jersey, 2001. (15671740)
2004
48
Vitritis and chorioretinitis in a patient with West Nile virus infection. (12583786)
2003
49
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus. (12954067)
2003
50
Isolation of eastern equine encephalitis virus and West Nile virus from crows during increased arbovirus surveillance in Connecticut, 2000. (12164299)
2002

Variations for West Nile Virus

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Clinvar genetic disease variations for West Nile Virus:

6
id Gene Name Type Significance SNP ID Assembly Location
1NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenicrs333GRCh37Chr 3, 46414947: 46414978

Expression for genes affiliated with West Nile Virus

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Expression patterns in normal tissues for genes affiliated with West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for genes affiliated with West Nile Virus

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Pathways related to West Nile Virus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3OAS1, TLR3, DDX58
2
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.3DDX58, TLR3, CREB3L1
3
Show member pathways
8.9DDX58, TLR3, OAS1, MX1
4
Show member pathways
8.4MX1, IFITM3, IFITM1, IFITM2, OAS1
5
Show member pathways
8.0IFITM3, IFITM1, IFITM2, OAS1, DDX58, MX1

Compounds for genes affiliated with West Nile Virus

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Compounds related to West Nile Virus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1imiquimod44 61 28 1112.6MX1, TLR3
2ifn-alpha449.6MX1, TLR3
3polyinosinic-polycytidylic acid449.5DDX58, TLR3
4ribavirin44 50 1111.5MX1, CCR5
52,5-oligoadenylate449.4MX1, OAS1, TLR3
6poly(i-c)449.3MX1, TLR3, DDX58
7rantes449.0DDX58, TLR3, CCR5, MX1

GO Terms for genes affiliated with West Nile Virus

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Cellular components related to West Nile Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.0MX1, CREB3L1, TLR3, TUSC3

Biological processes related to West Nile Virus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1detection of virusGO:0095979.6TLR3, DDX58
2positive regulation of interferon-beta productionGO:0327289.5TLR3, DDX58
3immune responseGO:0069559.4IFITM3, CCR5, IFITM2
4response to exogenous dsRNAGO:0433309.3TLR3, DDX58
5response to interferon-betaGO:0354569.3IFITM2, IFITM1, IFITM3
6response to interferon-alphaGO:0354559.3IFITM2, IFITM3, IFITM1
7negative regulation of viral entry into host cellGO:0465979.3IFITM2, IFITM3, IFITM1
8response to interferon-gammaGO:0343419.2IFITM3, IFITM1, IFITM2
9negative regulation of viral genome replicationGO:0450718.7MX1, IFITM1, IFITM2, IFITM3, OAS1
10type I interferon signaling pathwayGO:0603378.6IFITM2, IFITM1, IFITM3, MX1, OAS1
11cytokine-mediated signaling pathwayGO:0192218.5MX1, IFITM3, IFITM1, IFITM2, OAS1
12response to virusGO:0096158.3IFITM3, DDX58, OAS1, IFITM2, IFITM1, MX1
13defense response to virusGO:0516078.2OAS1, MX1, IFITM3, IFITM1, IFITM2, TLR3

Molecular functions related to West Nile Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:0037259.3OAS1, TLR3, DDX58

Products for genes affiliated with West Nile Virus

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Sources for West Nile Virus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet