MCID: WST005
MIFTS: 51

West Nile Virus

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 54 50 41
West Nile Virus, Susceptibility to 29 13
Encephalitis, West Nile Fever 69
West Nile Viral Infection 69
West-Nile Encephalitis 56
West Nile Fever 69
West-Nile Fever 56

Characteristics:

Orphanet epidemiological data:

56
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

OMIM 54 610379
Orphanet 56 ORPHA83476
UMLS via Orphanet 70 C0751583 C0043124
ICD10 via Orphanet 34 A92.3

Summaries for West Nile Virus

MedlinePlus : 41 west nile virus (wnv) is an infectious disease that first appeared in the united states in 1999. infected mosquitoes spread the virus that causes it. people who get wnv usually have no symptoms or mild symptoms. the symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. they can last a few days to several weeks, and usually go away on their own. if west nile virus enters the brain, however, it can be life-threatening. it may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. a physical exam, health history and laboratory tests can diagnose it. older people and those with weakened immune systems are most at risk. there are no specific vaccines or treatments for human wnv disease. the best way to avoid wnv is to prevent mosquito bites: use insect repellent get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels stay indoors between dusk and dawn, when mosquitoes are most active use screens on windows to keep mosquitoes out nih: national institute of allergy and infectious diseases

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to hepatitis c virus and west nile fever, and has symptoms including back pain, fever and headache. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Glycine and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord.

OMIM : 54
WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 hepatitis c virus 28.4 CCR5 CLEC4M DDX58 IFIH1 IFITM1 IRF3
2 west nile fever 11.9
3 west nile encephalitis 11.7
4 kunjin encephalitis 11.1
5 encephalitis 10.7
6 x-linked intellectual disability-precocious puberty-obesity syndrome 10.5 DDX58 IFIH1
7 japanese encephalitis 10.4
8 st. louis encephalitis 10.4
9 meningoencephalitis 10.3
10 chorioretinitis 10.3
11 meningitis 10.2
12 liver leiomyoma 10.2 CCR5 TLR3
13 sirenomelia 10.2 DDX58 IFIH1
14 retinitis 10.2
15 vaginal mullerian papilloma 10.2 CD209 IFITM3 MX1
16 poliomyelitis 10.1
17 bronchiolitis 10.1 DDX58 IFNA1 IRF3
18 neuronitis 10.1
19 tick-borne encephalitis 10.1
20 angiodysplasia of intestine 10.0 CD209 CLEC4M DDX58 TLR3
21 vasculitis 10.0
22 pulmonary tuberculosis 10.0 CD209 CLEC4M IFNA1 IRF3
23 murray valley encephalitis 10.0
24 chikungunya 10.0
25 retinal vasculitis 10.0
26 aseptic meningitis 10.0
27 rift valley fever 10.0
28 cerebellar ataxia 10.0
29 ataxia 10.0
30 eastern equine encephalitis 10.0
31 hepatitis 9.9
32 influenza 9.9
33 spinal cord disease 9.9
34 measles 9.9
35 choroiditis 9.9
36 crimean-congo hemorrhagic fever 9.9
37 quadriplegia 9.9
38 hemorrhagic fever 9.9
39 malaria 9.9
40 hepatitis c 9.9
41 kidney disease 9.9
42 myoclonus 9.9
43 gonococcal endophthalmia 9.9 CCR5 OAS1 RSAD2
44 erythema multiforme 9.8 CCR5 CD209 OAS1 TLR3
45 orchitis 9.7
46 endotheliitis 9.7
47 hepatitis b 9.7
48 severe acute respiratory syndrome 9.7
49 pneumococcal meningitis 9.7
50 leukemia 9.7

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


back pain, fever, headache, pain, pruritus, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Antibodies Phase 2,Phase 1
3 gamma-Globulins Phase 2,Phase 1
4 Immunoglobulins Phase 2,Phase 1
5 Immunoglobulins, Intravenous Phase 2,Phase 1
6 Rho(D) Immune Globulin Phase 2,Phase 1
7 Pharmaceutical Solutions Phase 1, Phase 2
8 Vaccines Phase 2,Phase 1
9 Antibodies, Monoclonal Phase 2,Phase 1
10
Aluminum sulfate Approved Phase 1 10043-01-3
11
Aluminum hydroxide Approved Phase 1 21645-51-2
12 Adjuvants, Immunologic Phase 1
13 Antacids Phase 1
14 Anti-Ulcer Agents Phase 1
15 Gastrointestinal Agents Phase 1

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801 Phase 4
2 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
3 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
4 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
5 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
6 Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRelâ„¢ (batch 20081217)]
7 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
8 Phase 1 Trial of Inactivated West Nile Virus Vaccine Completed NCT02337868 Phase 1
9 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
10 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
11 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
12 A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
13 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
14 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
15 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
16 Safety Study of HBV-002 West Nile Vaccine in Healthy Adults Completed NCT00707642 Phase 1
17 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1 AVI-4065 Injection
18 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
19 West Nile Virus Natural History Completed NCT00138463
20 Natural History of West Nile Virus Infection Completed NCT00069303
21 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166
22 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
23 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
24 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
25 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

id Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 29

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

39
Brain, Testes, Spinal Cord, Skin, T Cells, B Cells, Kidney

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 788)
id Title Authors Year
1
MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection. ( 28077630 )
2017
2
Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis. ( 28810044 )
2017
3
Epidemiologic and clinical parameters of West Nile virus infections in humans: a scoping review. ( 28877682 )
2017
4
West Nile virus (WNV) presenting as acute cerebellar ataxia in an immunocompetent patient. ( 28377090 )
2017
5
Application of replication-defective West Nile virus vector to non-flavivirus vaccine targets. ( 28925795 )
2017
6
Spectral and Hydrodynamic Analysis of West Nile Virus RNA-Protein Interactions by Multiwavelength Sedimentation Velocity in the Analytical Ultracentrifuge. ( 27977168 )
2017
7
The Degree of One Health Implementation in the West Nile Virus Integrated Surveillance in Northern Italy, 2016. ( 28929098 )
2017
8
Striking diflubenzuron resistance in Culex pipiens, the prime vector of West Nile Virus. ( 28916816 )
2017
9
The nucleolar helicase DDX56 redistributes to West Nile virus assembly sites. ( 27821284 )
2017
10
Minocycline has anti-inflammatory effects and reduces cytotoxicity in an ex vivo spinal cord slice culture model of West Nile virus infection. ( 28878079 )
2017
11
Zika virus infection confers protection against West Nile virus challenge in mice. ( 28928416 )
2017
12
A Snapshot Avian Surveillance Reveals West Nile Virus and Evidence of Wild Birds Participating in Toscana Virus Circulation. ( 28832259 )
2017
13
Detection of West Nile virus in six mosquito species in synchrony with seroconversion among sentinel chickens in India. ( 28061903 )
2017
14
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. ( 27795421 )
2017
15
An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors. ( 28873423 )
2017
16
The impact of weather and storm water management ponds on the transmission of West Nile virus. ( 28878963 )
2017
17
Pre-clinical development of a hydrogen peroxide-inactivated West Nile virus vaccine. ( 27919629 )
2017
18
Potential Reservoir and Associated Factors for West Nile Virus in Three Distinct Climatological Zones. ( 28873035 )
2017
19
Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus. ( 28861067 )
2017
20
A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses. ( 28062007 )
2017
21
Spatial distribution of West Nile virus in humans and mosquitoes in Israel, 2000-2014. ( 28882664 )
2017
22
Susceptibility and Antibody Response of the Laboratory Model Zebra Finch (Taeniopygia guttata) to West Nile Virus. ( 28045891 )
2017
23
Exploring vector-borne infection ecology in multi-host communities: A case study of West Nile virus. ( 27986465 )
2017
24
West Nile virus in Ontario, Canada: A twelve-year analysis of human case prevalence, mosquito surveillance, and climate data. ( 28829827 )
2017
25
A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4I930, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers. ( 28077583 )
2017
26
Comparison of assays for the detection of West Nile virus antibodies in equine serum after natural infection or vaccination. ( 28063471 )
2017
27
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5. ( 28659477 )
2017
28
VectorTesta8c West Nile Virus Antigen Assay in an Inhibition Platform as Field Screening Tool for Flavivirus Group-Specific Antibodies in Brazilian Equines. ( 28854109 )
2017
29
Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus. ( 27914931 )
2017
30
First Serological Evidence of West Nile Virus in Horses and Dogs from Corsica Island, France. ( 28075236 )
2017
31
Dengue, West Nile virus, chikungunya, Zika-and now Mayaro? ( 28859086 )
2017
32
Extinction of West Nile virus by Favipiravir through lethal mutagenesis. ( 28848019 )
2017
33
Characterizing environmental risk factors for West Nile virus in Quebec, Canada, using clinical data in humans and serology in pet dogs. ( 28835296 )
2017
34
Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012. ( 27935796 )
2017
35
West Nile virus meningitis in a patient with human immunodeficiency virus type 1 infection. ( 28831299 )
2017
36
STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease. ( 28927677 )
2017
37
Virulence determinants of West Nile virus: how can these be used for vaccine design? ( 28919920 )
2017
38
Field Methods and Sample Collection Techniques for the Surveillance of West Nile Virus in Avian Hosts. ( 27188560 )
2016
39
A Multiagency Approach to Reducing West Nile Virus Risk in Richmond County, Georgia, in 2015. ( 27613204 )
2016
40
Equine Immunoglobulin and Equine Neutralizing F(ab')a88 Protect Mice from West Nile Virus Infection. ( 27999340 )
2016
41
2014: A Record-Breaking Year for West Nile Virus Positive Mosquito Pools in Harris County and the City of Houston, Texas. ( 27613203 )
2016
42
Use of Testing for West Nile Virus and Other Arboviruses. ( 27537988 )
2016
43
Techniques for Experimental Infection of Mosquitoes with West Nile Virus. ( 27188557 )
2016
44
West Nile virus-associated brachial plexopathy. ( 27030459 )
2016
45
The Effect of West Nile Virus Infection on the Midgut Gene Expression of Culex pipiens quinquefasciatus Say (Diptera: Culicidae). ( 27999244 )
2016
46
Lessons from the Murine Models of West Nile Virus Infection. ( 27188550 )
2016
47
Statistical Tools for the Interpretation of Enzootic West Nile virus Transmission Dynamics. ( 27188561 )
2016
48
Estimating the economic impact of a possible equine and human epidemic of West Nile virus infection in Belgium. ( 27526394 )
2016
49
Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45. ( 27520967 )
2016
50
Propagation and Titration of West Nile Virus on Vero Cells. ( 27188547 )
2016

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh37 Chromosome 3, 46414947: 46414978

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CCR5 CD209 DDX58 IFIH1 IFITM1 IFITM2
2
Show member pathways
13.17 CCR5 DDX58 IFITM1 IFITM2 IFITM3 IFNA1
3
Show member pathways
12.55 CD209 CLEC4M DDX58 IFIH1 IFNA1 IRF3
4 12.49 IFNA1 IRF3 ITGAV ITGB3 MX1 TLR3
5 12.44 DDX58 IFIH1 IFNA1 IRF3 OAS1 RSAD2
6
Show member pathways
12.24 DDX58 IFIH1 IRF3 TLR3
7
Show member pathways
12.1 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 IRF3
8 11.95 DDX58 IFNA1 IRF3 OAS1 TLR3
9 11.94 CD209 CLEC4M ITGAV ITGB3
10 11.79 CD209 ITGAV ITGB3
11 11.62 ITGAV ITGB3 TLR3
12
Show member pathways
11.43 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
13
Show member pathways
11.03 DDX58 IRF3 MX1 OAS1
14 10.88 ITGAV ITGB3
15 10.68 ITGAV ITGB3
16 10.57 ITGAV ITGB3

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.72 CCR5 CD209 ITGAV ITGB3 TLR3
2 lamellipodium membrane GO:0031258 9.37 ITGAV ITGB3
3 ruffle membrane GO:0032587 9.33 DDX58 ITGAV ITGB3
4 filopodium membrane GO:0031527 9.26 ITGAV ITGB3
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.96 ITGAV ITGB3
6 integrin alphav-beta3 complex GO:0034683 8.62 ITGAV ITGB3

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 37)
id Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.88 CD209 CLEC4M ITGAV ITGB3
2 negative regulation of viral genome replication GO:0045071 9.87 C19orf66 IFITM1 IFITM2 IFITM3 MX1 OAS1
3 type I interferon signaling pathway GO:0060337 9.86 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
4 response to virus GO:0009615 9.81 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 MX1
5 negative regulation of type I interferon production GO:0032480 9.8 DDX58 IFIH1 IRF3
6 response to exogenous dsRNA GO:0043330 9.8 DDX58 IFNA1 IRF3 TLR3
7 innate immune response GO:0045087 9.77 CD209 CLEC4M DDX58 IFIH1 IFITM1 IFITM2
8 positive regulation of interferon-beta production GO:0032728 9.76 DDX58 IFIH1 IRF3 TLR3
9 negative regulation of viral entry into host cell GO:0046597 9.74 IFITM1 IFITM2 IFITM3
10 response to interferon-gamma GO:0034341 9.73 C19orf66 IFITM1 IFITM2 IFITM3
11 response to biotic stimulus GO:0009607 9.72 IFITM1 IFITM2 IFITM3
12 positive regulation of interferon-alpha production GO:0032727 9.71 DDX58 IFIH1 IRF3
13 response to interferon-alpha GO:0035455 9.7 IFITM1 IFITM2 IFITM3
14 response to interferon-beta GO:0035456 9.69 IFITM1 IFITM2 IFITM3
15 cell-substrate adhesion GO:0031589 9.67 ITGAV ITGB3
16 cell adhesion mediated by integrin GO:0033627 9.67 ITGAV ITGB3
17 viral genome replication GO:0019079 9.67 CD209 CLEC4M
18 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.66 ITGAV ITGB3
19 negative regulation of lipid storage GO:0010888 9.66 ITGAV ITGB3
20 response to type I interferon GO:0034340 9.65 C19orf66 MX1
21 cellular response to dsRNA GO:0071359 9.65 IRF3 TLR3
22 modulation by virus of host morphology or physiology GO:0019048 9.65 CD209 CLEC4M
23 detection of virus GO:0009597 9.65 DDX58 IFIH1 TLR3
24 cell-cell recognition GO:0009988 9.64 CD209 CLEC4M
25 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.64 ITGAV ITGB3
26 negative regulation of lipid transport GO:0032369 9.63 ITGAV ITGB3
27 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.62 ITGAV ITGB3
28 virion attachment to host cell GO:0019062 9.62 CD209 CLEC4M
29 MDA-5 signaling pathway GO:0039530 9.61 IFIH1 IRF3
30 peptide antigen transport GO:0046968 9.61 CD209 CLEC4M
31 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.6 DDX58 IFIH1
32 regulation of type III interferon production GO:0034344 9.59 DDX58 IFIH1
33 negative regulation of lipoprotein metabolic process GO:0050748 9.58 ITGAV ITGB3
34 defense response to virus GO:0051607 9.44 ABCF3 C19orf66 DDX58 IFIH1 IFITM1 IFITM2
35 cellular response to exogenous dsRNA GO:0071360 9.26 TLR3
36 immune system process GO:0002376 10.07 CD209 CLEC4M DDX58 IFIH1 IFITM1 IRF3
37 viral process GO:0016032 10.06 CCR5 CD209 CLEC4M DDX58 IFIH1 IRF3

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.93 DDX58 IFIH1 IRF3 ITGB3 MX1 TLR3
2 mannose binding GO:0005537 9.48 CD209 CLEC4M
3 insulin-like growth factor I binding GO:0031994 9.43 ITGAV ITGB3
4 virion binding GO:0046790 9.37 CD209 CLEC4M
5 coreceptor activity GO:0015026 9.33 CCR5 ITGAV ITGB3
6 neuregulin binding GO:0038132 9.32 ITGAV ITGB3
7 C-X3-C chemokine binding GO:0019960 9.26 ITGAV ITGB3
8 double-stranded RNA binding GO:0003725 9.26 DDX58 IFIH1 OAS1 TLR3
9 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4M ITGAV ITGB3
10 protein binding GO:0005515 10.31 ABCF3 C19orf66 CCR5 CD209 DDX58 IFIH1

Sources for West Nile Virus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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