MCID: WST005
MIFTS: 34

West Nile Virus malady

Summaries for West Nile Virus

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 West nile virus (wnv) is an infectious disease that first appeared in the united states in 1999. infected mosquitoes spread the virus that causes it. people who get wnv usually have no symptoms or mild symptoms. the symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. they can last a few days to several weeks, and usually go away on their own. if west nile virus enters the brain, however, it can be life-threatening. it may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. a physical exam, health history and laboratory tests can diagnose it. older people and those with weakened immune systems are most at risk. there are no specific vaccines or treatments for human wnv disease. the best way to avoid wnv is to prevent mosquito bites: use insect repellent get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels stay indoors between dusk and dawn, when mosquitoes are most active use screens on windows to keep mosquitoes out nih: national institute of allergy and infectious diseases

MalaCards: West Nile Virus is related to west nile encephalitis and encephalitis. An important gene associated with West Nile Virus is CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene)), and among its related pathways are Type III interferon signaling and IL27-mediated signaling events. The compounds rantes and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and skin, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the... more...

Description from OMIM:46 610379

Aliases & Classifications for West Nile Virus

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42NIH Rare Diseases, 46OMIM, 33MedlinePlus
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Aliases & Descriptions:

west nile virus 42 46 33


Related Diseases for West Nile Virus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to west nile virus

Clinical Features for West Nile Virus

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46OMIM
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Clinical features from OMIM:

610379

Drugs & Therapeutics for West Nile Virus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for West Nile Virus

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Anatomical Context for West Nile Virus

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32MalaCards
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MalaCards organs/tissues related to West Nile Virus:

32
Brain, Spinal cord, Skin, Testes

Animal Models for West Nile Virus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to West Nile Virus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.0IFITM1, HELLS, CREB3L1, STAT2, DDX58, TYK2
2MP:00053879.6OASL, CCR5, TLR3, IFITM1, IFIT2, HELLS
3MP:00053769.5IFIT2, IFITM1, TLR3, CCR5, HELLS, IRF3

Publications for West Nile Virus

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Genetic Variations for West Nile Virus

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Expression for genes affiliated with West Nile Virus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for genes affiliated with West Nile Virus

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology, 51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with West Nile Virus

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to West Nile Virus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4410.6IRF3
22,5-oligoadenylate4410.4OAS1, OASL, MX1, STAT2, TLR3
3poly(i-c)4410.4TLR3, IRF3, DDX58, MX1, RSAD2
4polyinosinic-polycytidylic acid4410.4DDX58, IRF3, TLR3
5ifn-alpha4410.4TLR3, IRF3, STAT2, TYK2, MX1
6ribavirin44 49 1112.3CCR5, HELLS, MX1
7retinoic acid44 2411.2CCR5, TLR3, HELLS, IRF3, STAT2, DDX58
8mdms4410.1IRF3, CCR5
9tyrosine4410.1TLR3, HELLS, IRF3, STAT2, TYK2, MSBP1
10serine4410.0CCR5, TLR3, HELLS, IRF3, STAT2, TYK2

GO Terms for genes affiliated with West Nile Virus

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16Gene Ontology
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Cellular components related to West Nile Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.0IRF3, STAT2, DDX58, TYK2, MX1, OASL
2cytoplasmGO:0057379.6OAS1, CCR5, TLR3, IFIT2, IRF3, STAT2

Biological processes related to West Nile Virus according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of viral entry into host cellGO:04659710.6IFITM1, IFITM2, IFITM3
2response to interferon-betaGO:03545610.6IFITM3, IFITM2, IFITM1
3response to interferon-alphaGO:03545510.5IFITM1, IFITM2, IFITM3
4detection of virusGO:00959710.5TLR3, DDX58
5response to exogenous dsRNAGO:04333010.5DDX58, IRF3, TLR3
6response to interferon-gammaGO:03434110.5IFITM1, IFITM2, IFITM3
7positive regulation of interferon-beta productionGO:03272810.5DDX58, IRF3, TLR3
8cellular response to interferon-alphaGO:03545710.4OAS1, IFIT2
9interferon-gamma-mediated signaling pathwayGO:06033310.3IRF3, OASL, OAS1
10negative regulation of viral genome replicationGO:04507110.3IFITM1, IFITM2, IFITM3, MX1, RSAD2, OASL
11modulation by virus of host morphology or physiologyGO:01904810.3RSAD2, DDX58, STAT2, IRF3, CCR5
12response to virusGO:00961510.3IFITM1, IFITM2, IFIT2, IFITM3, DDX58, MX1
13immune responseGO:00695510.3TNFSF9, IFITM3, IFITM2, CCR5
14positive regulation of interferon-alpha productionGO:03272710.3IRF3, DDX58
15type I interferon-mediated signaling pathwayGO:06033710.2IFIT2, IFITM3, IRF3, STAT2, TYK2, MX1
16cytokine-mediated signaling pathwayGO:01922110.2IFITM1, IFITM2, IFIT2, IFITM3, IRF3, STAT2
17defense response to virusGO:05160710.1IFIT2, IFITM3, IRF3, STAT2, MX1, RSAD2
18innate immune responseGO:0450879.9TLR3, IRF3, DDX58, MX1, RSAD2

Molecular functions related to West Nile Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:00372510.0OAS1, OASL, DDX58, TLR3
2protein bindingGO:0055159.6HELLS, IFITM3, IFIT2, IFITM1, TLR3, IRF3

Products for genes affiliated with West Nile Virus

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  • Antibodies
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  • Antibodies

Sources for West Nile Virus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet