MCID: WST005
MIFTS: 46

West Nile Virus malady

Summaries for West Nile Virus

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 West nile virus (wnv) is an infectious disease that first appeared in the united states in 1999. infected mosquitoes spread the virus that causes it. people who get wnv usually have no symptoms or mild symptoms. the symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. they can last a few days to several weeks, and usually go away on their own. if west nile virus enters the brain, however, it can be life-threatening. it may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. a physical exam, health history and laboratory tests can diagnose it. older people and those with weakened immune systems are most at risk. there are no specific vaccines or treatments for human wnv disease. the best way to avoid wnv is to prevent mosquito bites: use insect repellent get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels stay indoors between dusk and dawn, when mosquitoes are most active use screens on windows to keep mosquitoes out nih: national institute of allergy and infectious diseases

MalaCards: West Nile Virus is related to west nile encephalitis and measles. An important gene associated with West Nile Virus is CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene)), and among its related pathways are Type III interferon signaling and IL27-mediated signaling events. The compounds rantes and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:64 West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the... more...

Description from OMIM:47 610379

Aliases & Classifications for West Nile Virus

Sources:
43NIH Rare Diseases, 47OMIM, 34MedlinePlus
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Aliases & Descriptions:

west nile virus 43 47 34


Related Diseases for West Nile Virus

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to west nile virus

Clinical Features for West Nile Virus

Sources:
47OMIM
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Clinical features from OMIM:

610379

Drugs & Therapeutics for West Nile Virus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for West Nile Virus

Drug clinical trials:

Search ClinicalTrials for West Nile Virus

Search NIH Clinical Center for West Nile Virus

Search CenterWatch for West Nile Virus

Genetic Tests for West Nile Virus

Anatomical Context for West Nile Virus

Sources:
33MalaCards
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MalaCards organs/tissues related to West Nile Virus:

33
Whole blood, Brain, Spinal cord, Kidney, Pancreas, Salivary gland, Skin, Monocytes, Nk cells, T cells, B cells, Endothelial, Thalamus

Animal Models for West Nile Virus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to West Nile Virus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.0IFITM1, HELLS, CREB3L1, STAT2, DDX58, TYK2
2MP:00053879.6OASL, CCR5, TLR3, IFITM1, IFIT2, HELLS
3MP:00053769.5IFIT2, IFITM1, TLR3, CCR5, HELLS, IRF3

Publications for West Nile Virus

Sources:
51PubMed
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Articles related to West Nile Virus:

(show top 50)    (show all 658)
idTitleAuthorsYear
1
Allele-specific qRT-PCR demonstrates superior detection of single nucleotide polymorphisms as genetic markers for West Nile virus compared to LuminexAr and quantitative sequencing. (24121135)
2014
2
West Nile Virus Infection in Kidney and Pancreas Transplant Recipients in the Dallas-Fort Worth Metroplex During the 2012 Texas Epidemic. (24406451)
2014
3
Death Receptor-Mediated Apoptotic Signaling Is Activated in the Brain following Infection with West Nile Virus in the Absence of a Peripheral Immune Response. (24198425)
2014
4
West Nile Virus Infection in Horses in Jordan: Clinical Cases, Seroprevalence and Risk Factors. (24393369)
2014
5
Clinical features of West Nile virus epidemic in Dallas, Texas, 2012. (24316017)
2014
6
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. (24333681)
2013
7
Arenavirus and West Nile virus in solid organ transplantation. (23465029)
2013
8
West Nile virus genome with glycosylated envelope protein and deletion of alpha helices 1, 2, and 4 in the capsid protein is noninfectious and efficiently secretes subviral particles. (24049184)
2013
9
Ecology of potential West Nile virus vectors in Southeastern Louisiana: enzootic transmission in the relative absence of Culex quinquefasciatus. (23478575)
2013
10
Cloning and expression of an envelope gene of West Nile virus and evaluation of the protein for use in an IgM ELISA. (23357292)
2013
11
Antibodies to West Nile virus in wild and farmed crocodiles in southeastern Mexico. (23778623)
2013
12
West Nile Virus equine serosurvey in the Czech and Slovak republics. (23919605)
2013
13
Modeling monthly variation of Culex tarsalis (Diptera: Culicidae) abundance and West Nile Virus infection rate in the Canadian Prairies. (23880728)
2013
14
West Nile virus lineage 2 strain in Greece, 2012. (23697609)
2013
15
The mosquito borne West Nile virus infection: is it threating to Egypt or a neglected endemic disease? (23697018)
2013
16
West nile virus antibody prevalence in horses of Ukraine. (24100889)
2013
17
Development of a strand-specific real-time qRT-PCR for the accurate detection and quantitation of West Nile virus RNA. (23965252)
2013
18
West Nile virus, Texas, USA, 2012. (24210089)
2013
19
West Nile virus in mosquitoes in Greece. (23371497)
2013
20
In vitro and in vivo activity of AS101 against West Nile virus (WNV). (22445690)
2012
21
Cooperative interactions in the West Nile virus mutant swarm. (22541042)
2012
22
Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway. (23027947)
2012
23
Current practices and evaluation of screening solid organ donors for West Nile virus. (22606990)
2012
24
Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011. (22687827)
2012
25
Seroprevalence and risk factors associated to West Nile virus in horses from Andalusia, Southern Spain. (22776513)
2012
26
West Nile virus: A re-emerging pathogen revisited. (24175211)
2012
27
Entomologic investigations during an outbreak of West Nile virus disease in Maricopa County, Arizona, 2010. (23109372)
2012
28
Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina. (22666870)
2012
29
Findings of long-term depression up to 8 years post infection from West Nile virus. (23929558)
2012
30
West Nile virus vector Culex modestus established in southern England. (22316288)
2012
31
Accumulation of ubiquitinated proteins is related to West Nile virus-induced neuronal apoptosis. (22129084)
2012
32
Feeding patterns of potential West Nile virus vectors in south-west Spain. (22745781)
2012
33
Cell-intrinsic innate immune control of West Nile virus infection. (22726607)
2012
34
Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group. (22724010)
2012
35
Predicting weekly variation of Culex tarsalis (Diptera: Culicidae) West Nile virus infection in a newly endemic region, the Canadian prairies. (23025197)
2012
36
Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. (22123531)
2012
37
West Nile virus meningoencephalitis imported into Germany. (23017806)
2012
38
A West Nile virus vaccine. (21938496)
2011
39
Decelerating spread of West Nile virus by percolation in a heterogeneous urban landscape. (21829332)
2011
40
Serosurvey of West Nile virus and other flaviviruses of the Japanese encephalitis antigenic complex in birds from Andalusia, southern Spain. (21142954)
2011
41
West Nile Virus: a progression from unknown to endemic. (21999076)
2011
42
West Nile virus neuroinvasive disease presenting with acute flaccid paralysis and bilateral sensorineural hearing loss. (21442461)
2011
43
Requirement of glycosylation of West Nile virus envelope protein for infection of, but not spread within, Culex quinquefasciatus mosquito vectors. (21813861)
2011
44
Ability of selected Kenyan mosquito (Diptera: Culicidae) species to transmit West Nile virus under laboratory conditions. (22238879)
2011
45
High throughput quantitative colorimetric microneutralization assay for the confirmation and differentiation of West Nile Virus and St. Louis encephalitis virus. (20207881)
2010
46
Severe tick-borne encephalitis in a patient previously infected by West Nile virus. (19086342)
2008
47
The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus. (18339459)
2008
48
West Nile virus-induced neuroinflammation: glial infection and capsid protein-mediated neurovirulence. (17670819)
2007
49
Ischemic and hemorrhagic retinal vasculitis associated with West Nile virus infection. (16508444)
2006
50
Evaluation of immunoglobulin M (IgM) and IgG enzyme immunoassays in serologic diagnosis of West Nile Virus infection. (10834982)
2000

Genetic Variations for West Nile Virus

Expression for genes affiliated with West Nile Virus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for genes affiliated with West Nile Virus

Sources:
38NCBI BioSystems Database, 53R&D Systems, 4Cell Signaling Technology, 52QIAGEN, 30KEGG, 54Reactome, 12EMD Millipore
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Compounds for genes affiliated with West Nile Virus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to West Nile Virus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4510.6IRF3
22,5-oligoadenylate4510.4OAS1, OASL, MX1, STAT2, TLR3
3poly(i-c)4510.4TLR3, IRF3, DDX58, MX1, RSAD2
4polyinosinic-polycytidylic acid4510.4DDX58, IRF3, TLR3
5ifn-alpha4510.4TLR3, IRF3, STAT2, TYK2, MX1
6ribavirin45 50 1112.3CCR5, HELLS, MX1
7retinoic acid45 2411.2CCR5, TLR3, HELLS, IRF3, STAT2, DDX58
8mdms4510.1IRF3, CCR5
9tyrosine4510.1TLR3, HELLS, IRF3, STAT2, TYK2, MSBP1
10serine4510.0CCR5, TLR3, HELLS, IRF3, STAT2, TYK2

GO Terms for genes affiliated with West Nile Virus

Sources:
16Gene Ontology
See all sources

Cellular components related to West Nile Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.0IRF3, STAT2, DDX58, TYK2, MX1, OASL
2cytoplasmGO:0057379.6OAS1, CCR5, TLR3, IFIT2, IRF3, STAT2

Biological processes related to West Nile Virus according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of viral entry into host cellGO:04659710.6IFITM1, IFITM2, IFITM3
2response to interferon-betaGO:03545610.6IFITM3, IFITM2, IFITM1
3response to interferon-alphaGO:03545510.5IFITM1, IFITM2, IFITM3
4detection of virusGO:00959710.5TLR3, DDX58
5response to exogenous dsRNAGO:04333010.5DDX58, IRF3, TLR3
6response to interferon-gammaGO:03434110.5IFITM1, IFITM2, IFITM3
7positive regulation of interferon-beta productionGO:03272810.5DDX58, IRF3, TLR3
8cellular response to interferon-alphaGO:03545710.4OAS1, IFIT2
9interferon-gamma-mediated signaling pathwayGO:06033310.3IRF3, OASL, OAS1
10negative regulation of viral genome replicationGO:04507110.3IFITM1, IFITM2, IFITM3, MX1, RSAD2, OASL
11modulation by virus of host morphology or physiologyGO:01904810.3RSAD2, DDX58, STAT2, IRF3, CCR5
12response to virusGO:00961510.3IFITM1, IFITM2, IFIT2, IFITM3, DDX58, MX1
13immune responseGO:00695510.3TNFSF9, IFITM3, IFITM2, CCR5
14positive regulation of interferon-alpha productionGO:03272710.3IRF3, DDX58
15type I interferon-mediated signaling pathwayGO:06033710.2IFIT2, IFITM3, IRF3, STAT2, TYK2, MX1
16cytokine-mediated signaling pathwayGO:01922110.2IFITM1, IFITM2, IFIT2, IFITM3, IRF3, STAT2
17defense response to virusGO:05160710.1IFIT2, IFITM3, IRF3, STAT2, MX1, RSAD2
18innate immune responseGO:0450879.9TLR3, IRF3, DDX58, MX1, RSAD2

Molecular functions related to West Nile Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:00372510.0OAS1, OASL, DDX58, TLR3
2protein bindingGO:0055159.6HELLS, IFITM3, IFIT2, IFITM1, TLR3, IRF3

Products for genes affiliated with West Nile Virus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for West Nile Virus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet