MCID: WST005
MIFTS: 53

West Nile Virus malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for West Nile Virus

Aliases & Descriptions for West Nile Virus:

Name: West Nile Virus 54 50 41
West Nile Virus, Susceptibility to 54 29 13
Encephalitis, West Nile Fever 69
West Nile Viral Infection 69
West-Nile Encephalitis 56
West Nile Fever 69
West-Nile Fever 56

Characteristics:

Orphanet epidemiological data:

56
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

OMIM 54 610379
Orphanet 56 ORPHA83476
ICD10 via Orphanet 34 A92.3

Summaries for West Nile Virus

MedlinePlus : 41 west nile virus (wnv) is an infectious disease that first appeared in the united states in 1999. infected mosquitoes spread the virus that causes it. people who get wnv usually have no symptoms or mild symptoms. the symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. they can last a few days to several weeks, and usually go away on their own. if west nile virus enters the brain, however, it can be life-threatening. it may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. a physical exam, health history and laboratory tests can diagnose it. older people and those with weakened immune systems are most at risk. there are no specific vaccines or treatments for human wnv disease. the best way to avoid wnv is to prevent mosquito bites: use insect repellent get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels stay indoors between dusk and dawn, when mosquitoes are most active use screens on windows to keep mosquitoes out nih: national institute of allergy and infectious diseases

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to severe acute respiratory syndrome and hepatitis c virus, and has symptoms including back pain, fever and headache. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Oseltamivir and Nitazoxanide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotype is immune system.

OMIM : 54 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle... (610379) more...

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 severe acute respiratory syndrome 29.8 DDX58 IFNA1 IRF3
2 hepatitis c virus 26.3 ABCF3 C19orf66 CCR5 CD209 CLEC4M DDX58
3 west nile fever 11.9
4 west nile encephalitis 11.7
5 kunjin encephalitis 11.1
6 encephalitis 10.7
7 japanese encephalitis 10.4
8 st. louis encephalitis 10.4
9 meningoencephalitis 10.3
10 chorioretinitis 10.3
11 meningitis 10.2
12 retinitis 10.1
13 poliomyelitis 10.1
14 vaginal mullerian papilloma 10.1 CD209 IFITM3 MX1
15 tick-borne encephalitis 10.1
16 neuronitis 10.1
17 mineral metabolism disease 10.1 CD209 DDX58 OAS1
18 hyperimmunoglobulin syndrome 10.1 CD209 CLEC4M IFNA1 IRF3
19 x-linked intellectual disability, pai type 10.1 DDX58 IFIH1
20 anus leiomyosarcoma 10.1 CCR5 CD209 IFNA1
21 hydrops of gallbladder 10.0 CCR5 OAS1 RSAD2
22 skeletal dysplasias 10.0 DDX58 IFIH1
23 argentine hemorrhagic fever 10.0 CCR5 CD209 OAS1 TLR3
24 aseptic meningitis 10.0
25 rift valley fever 10.0
26 ataxia 10.0
27 cerebellar ataxia 10.0
28 eastern equine encephalitis 10.0
29 murray valley encephalitis 10.0
30 vasculitis 10.0
31 methylmalonic aciduria and homocystinuria, cblj type 10.0 IFNA1 MX1 OAS1
32 senile cataract 9.9 DDX58 IFITM2 IFITM3 IFNA1 RSAD2
33 fungal gastritis 9.9 IFNA1 ITGAV MX1 OAS1
34 crimean-congo hemorrhagic fever 9.9
35 quadriplegia 9.9
36 hemorrhagic fever 9.9
37 malaria 9.9
38 kidney disease 9.9
39 myoclonus 9.9
40 influenza 9.9
41 spinal cord disease 9.9
42 measles 9.9
43 choroiditis 9.9
44 retinal vasculitis 9.9
45 eczematous dermatitis of eyelid 9.9 CLEC4M DDX58 IFNA1 IRF3 TLR3
46 sexual masochism 9.9 CD209 CLEC4M DDX58 HELLS TLR3
47 graft-versus-host disease, protection against 9.8 CCR5 CD209 CLEC4M ITGAV ITGB3 TLR3
48 trachoma 9.8 IRF3 MX1 TLR3
49 gastroduodenitis 9.8 CD209 DDX58 IFIH1 IFNA1 TLR3
50 plantar fasciitis 9.8 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


back pain, fever, headache, pain, pruritus, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to West Nile Virus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCR5 CLEC4M DDX58 HELLS IFIH1 IFITM3

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved Phase 3 204255-11-8, 196618-13-0 65028
2
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
3 Anti-Infective Agents Phase 3,Phase 2
4 Antiviral Agents Phase 3,Phase 2
5
Lactitol Phase 3 585-86-4 3871
6 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
7 Vaccines Phase 3,Phase 2,Phase 1
8 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
9 Antiparasitic Agents Phase 3
10
Ribavirin Approved Phase 2 36791-04-5 37542
11
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
12
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
13
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
14 Antimetabolites Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Immunoglobulin G Phase 2,Phase 1
17 Immunoglobulins Phase 2,Phase 1
18 gamma-Globulins Phase 2,Phase 1
19 Immunoglobulins, Intravenous Phase 2,Phase 1
20 Antibodies, Monoclonal Phase 2,Phase 1
21 Rho(D) Immune Globulin Phase 2,Phase 1
22 Antibodies Phase 2,Phase 1
23
Aluminum hydroxide Approved Phase 1 21645-51-2
24 Adjuvants, Immunologic Phase 1
25 Gastrointestinal Agents Phase 1
26 Aluminum sulfate Phase 1
27 Antacids Phase 1
28 Anti-Ulcer Agents Phase 1
29
Natalizumab Approved, Investigational 189261-10-7

Interventional clinical trials:

(show all 39)
id Name Status NCT ID Phase
1 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801 Phase 4
2 A Study to Evaluate the Immunogenicity of Quadrivalent Live Attenuated Influenza Vaccine (LAIV) in Children Completed NCT01091246 Phase 3
3 A Study to Evaluate the Safety and Immunogenicity of 4 Doses of MenACWY Conjugate Vaccine, Administered Concomitantly With Routine Vaccines, Among Infants Aged 2 Months Completed NCT01000311 Phase 3
4 Study to Evaluate the Safety of Novartis MenACWY Conjugate Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants Completed NCT00806195 Phase 3
5 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
6 Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza Completed NCT01610245 Phase 3
7 Immunogenicity and Safety of Pediatric Vaccines When Administered With Menactra® in Healthy Toddlers Completed NCT00422292 Phase 3
8 Evaluation of Safety and Immunogenicity of Co-administering HPV Vaccine With Other Vaccines in Healthy Female Subjects Completed NCT00369824 Phase 3
9 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2
10 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2
11 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2
12 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
13 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
14 Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis Completed NCT01856205 Phase 2
15 Immunogenicity and Safety of GlaxoSmithKline Biologicals' MMRV Vaccine vs. ProQuad® in Children 12-14 Months of Age Completed NCT00578175 Phase 2
16 Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Larynx or Oropharynx Cancer Completed NCT00014118 Phase 2
17 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
18 Phase 1 Trial of Inactivated West Nile Virus Vaccine Completed NCT02337868 Phase 1
19 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
20 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1
21 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1
22 A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults Completed NCT00515385 Phase 1
23 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1
24 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
25 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
26 Safety Study of HBV-002 West Nile Vaccine in Healthy Adults Completed NCT00707642 Phase 1
27 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1
28 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1
29 West Nile Virus Natural History Completed NCT00138463
30 Natural History of West Nile Virus Infection Completed NCT00069303
31 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166
32 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
33 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
34 JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With Natalizumab Completed NCT01070836
35 An Observational Study to Assess Respiratory Syncytial Virus (RSV) Respiratory Events Among Premature Infants Completed NCT00983606
36 Prevalence of Antibodies to Selected Porcine Viruses in Patients With Cystic Fibrosis Receiving Porcine-derived Pancreatic Enzyme Replacement Therapy Completed NCT01858519
37 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
38 CA-IX, p16, Proliferative Markers, and HPV in Diagnosing Cervical Lesions in Patients With Abnormal Cervical Cells Recruiting NCT00892866
39 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

id Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 29

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

39
Brain, Testes, Skin, Spinal Cord, T Cells, B Cells, Kidney

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 763)
id Title Authors Year
1
Susceptibility and Antibody Response of the Laboratory Model Zebra Finch (Taeniopygia guttata) to West Nile Virus. ( 28045891 )
2017
2
Spectral and Hydrodynamic Analysis of West Nile Virus RNA-Protein Interactions by Multiwavelength Sedimentation Velocity in the Analytical Ultracentrifuge. ( 27977168 )
2017
3
Pre-clinical development of a hydrogen peroxide-inactivated West Nile virus vaccine. ( 27919629 )
2017
4
Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus. ( 27914931 )
2017
5
A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4I930, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers. ( 28077583 )
2017
6
Comparison of assays for the detection of West Nile virus antibodies in equine serum after natural infection or vaccination. ( 28063471 )
2017
7
First Serological Evidence of West Nile Virus in Horses and Dogs from Corsica Island, France. ( 28075236 )
2017
8
Exploring vector-borne infection ecology in multi-host communities: A case study of West Nile virus. ( 27986465 )
2017
9
Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012. ( 27935796 )
2017
10
Detection of West Nile virus in six mosquito species in synchrony with seroconversion among sentinel chickens in India. ( 28061903 )
2017
11
A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses. ( 28062007 )
2017
12
MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection. ( 28077630 )
2017
13
West Nile virus (WNV) presenting as acute cerebellar ataxia in an immunocompetent patient. ( 28377090 )
2017
14
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. ( 27353580 )
2016
15
Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45. ( 27520967 )
2016
16
Ecology of West Nile virus across four European countries: review of weather profiles, vector population dynamics and vector control response. ( 27590848 )
2016
17
Epidemiological and clinical aspects on West Nile virus, a globally emerging pathogen. ( 27207312 )
2016
18
Evaluation of Some Plant Fruit Extracts for the Control of West Nile Virus Vector Culex pipiens (Diptera: Culicidae). ( 28032112 )
2016
19
MRI Ventral Nerve Root Enhancement in Five Patients Presenting With Extremity Weakness Secondary to Neuroinvasive West Nile Virus. ( 27552389 )
2016
20
Equine Immunoglobulin and Equine Neutralizing F(ab')a88 Protect Mice from West Nile Virus Infection. ( 27999340 )
2016
21
Severe West Nile virus meningoencephalitis in a pediatric renal transplant recipient: successful recovery and long-term neuropsychological outcome. ( 27470315 )
2016
22
Purpura fulminans associated with acute West Nile virus encephalitis. ( 26686320 )
2016
23
Exploration of West Nile Virus Infection in Mouse Models. ( 27188551 )
2016
24
Propagation and Titration of West Nile Virus on Vero Cells. ( 27188547 )
2016
25
Ecological differentiation of members of the Culex pipiens complex, potential vectors of West Nile virus and Rift Valley fever virus in Algeria. ( 27534938 )
2016
26
Genetic evidence for circulation of Kunjin-related West Nile virus strain in Iran. ( 28035118 )
2016
27
Methodology for Identifying Host Factors Involved in West Nile Virus Infection. ( 27188554 )
2016
28
Immunogenicity and protective efficacy of recombinant Modified Vaccinia virus Ankara candidate vaccines delivering West Nile virus envelope antigens. ( 26939903 )
2016
29
Techniques for Experimental Infection of Mosquitoes with West Nile Virus. ( 27188557 )
2016
30
MicroRNA reduction of neuronal West Nile virus replication attenuates and affords a protective immune response in mice. ( 27637937 )
2016
31
Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis. ( 26638028 )
2016
32
West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms. ( 27548738 )
2016
33
Functional Analysis of West Nile Virus Proteins in Human Cells. ( 27188549 )
2016
34
Bibliometric assessment of scientific production of literature of West Nile Virus. ( 27659112 )
2016
35
Detection of West Nile virus and tick-borne encephalitis virus in birds in Slovakia, using a universal primer set. ( 27001305 )
2016
36
Identification of Climatic Factors Affecting the Epidemiology of Human West Nile Virus Infections in Northern Greece. ( 27631082 )
2016
37
The Effect of West Nile Virus Infection on the Midgut Gene Expression of Culex pipiens quinquefasciatus Say (Diptera: Culicidae). ( 27999244 )
2016
38
Detection Protocols for West Nile Virus in Mosquitoes, Birds, and Nonhuman Mammals. ( 27188559 )
2016
39
West Nile Virus Encephalitis in a Patient with Neuroendocrine Carcinoma. ( 27516915 )
2016
40
Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis. ( 27211830 )
2016
41
A Multiagency Approach to Reducing West Nile Virus Risk in Richmond County, Georgia, in 2015. ( 27613204 )
2016
42
Evaluating the feeding preferences of West Nile virus mosquito vectors using bird-baited traps. ( 27580694 )
2016
43
Non-coding subgenomic flavivirus RNA is processed by the mosquito RNAi machinery and determines West Nile virus transmission by Culex pipiens mosquitoes. ( 27581979 )
2016
44
Age-related alterations in immune responses to West Nile virus infection. ( 27612657 )
2016
45
Safe Handling of West Nile Virus in the Insectary. ( 27188556 )
2016
46
West Nile Virus Spreads Transsynaptically within the Pathways of Motor Control: Anatomical and Ultrastructural Mapping of Neuronal Virus Infection in the Primate Central Nervous System. ( 27617450 )
2016
47
Adult-onset opsoclonus-myoclonus syndrome due to West Nile Virus treated with intravenous immunoglobulin. ( 27473195 )
2016
48
Blood group A and D negativity are associated with symptomatic West Nile virus infection. ( 27189860 )
2016
49
Generating West Nile Virus from an Infectious Clone. ( 27188548 )
2016
50
Estimating the economic impact of a possible equine and human epidemic of West Nile virus infection in Belgium. ( 27526394 )
2016

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh37 Chromosome 3, 46414947: 46414978

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CCR5 CD209 DDX58 IFIH1 IFITM1 IFITM2
2
Show member pathways
13.17 CCR5 DDX58 IFITM1 IFITM2 IFITM3 IFNA1
3
Show member pathways
12.71 DDX58 IFIH1 IFNA1 IRF3 TLR3
4
Show member pathways
12.55 CD209 CLEC4M DDX58 IFIH1 IFNA1 IRF3
5 12.44 DDX58 IFIH1 IFNA1 IRF3 OAS1 RSAD2
6
Show member pathways
12.22 DDX58 IFIH1 IRF3 TLR3
7
Show member pathways
12.1 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 IRF3
8 11.95 DDX58 IFNA1 IRF3 OAS1 TLR3
9 11.94 CD209 CLEC4M ITGAV ITGB3
10 11.79 CD209 ITGAV ITGB3
11 11.6 ITGAV ITGB3 TLR3
12
Show member pathways
11.43 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
13
Show member pathways
11.03 DDX58 IRF3 MX1 OAS1
14 10.88 ITGAV ITGB3
15 10.67 ITGAV ITGB3
16 10.56 ITGAV ITGB3

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CCR5 CD209 ITGAV ITGB3 TLR3
2 lamellipodium membrane GO:0031258 9.37 ITGAV ITGB3
3 ruffle membrane GO:0032587 9.33 DDX58 ITGAV ITGB3
4 filopodium membrane GO:0031527 9.32 ITGAV ITGB3
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.96 ITGAV ITGB3
6 integrin alphav-beta3 complex GO:0034683 8.62 ITGAV ITGB3

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 37)
id Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.87 CD209 CLEC4M ITGAV ITGB3
2 negative regulation of viral genome replication GO:0045071 9.87 C19orf66 IFITM1 IFITM2 IFITM3 MX1 OAS1
3 type I interferon signaling pathway GO:0060337 9.86 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
4 response to virus GO:0009615 9.81 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 MX1
5 negative regulation of type I interferon production GO:0032480 9.8 DDX58 IFIH1 IRF3
6 response to exogenous dsRNA GO:0043330 9.8 DDX58 IFNA1 IRF3 TLR3
7 defense response to virus GO:0051607 9.77 ABCF3 C19orf66 DDX58 IFIH1 IFITM1 IFITM2
8 positive regulation of interferon-beta production GO:0032728 9.76 DDX58 IFIH1 IRF3 TLR3
9 negative regulation of viral entry into host cell GO:0046597 9.73 IFITM1 IFITM2 IFITM3
10 response to interferon-gamma GO:0034341 9.73 C19orf66 IFITM1 IFITM2 IFITM3
11 response to biotic stimulus GO:0009607 9.72 IFITM1 IFITM2 IFITM3
12 positive regulation of interferon-alpha production GO:0032727 9.71 DDX58 IFIH1 IRF3
13 response to interferon-alpha GO:0035455 9.7 IFITM1 IFITM2 IFITM3
14 response to interferon-beta GO:0035456 9.69 IFITM1 IFITM2 IFITM3
15 negative chemotaxis GO:0050919 9.67 ITGAV ITGB3
16 cell-substrate adhesion GO:0031589 9.67 ITGAV ITGB3
17 cell adhesion mediated by integrin GO:0033627 9.67 ITGAV ITGB3
18 viral genome replication GO:0019079 9.66 CD209 CLEC4M
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.66 ITGAV ITGB3
20 negative regulation of lipid storage GO:0010888 9.65 ITGAV ITGB3
21 response to type I interferon GO:0034340 9.65 C19orf66 MX1
22 modulation by virus of host morphology or physiology GO:0019048 9.65 CD209 CLEC4M
23 detection of virus GO:0009597 9.65 DDX58 IFIH1 TLR3
24 cellular response to dsRNA GO:0071359 9.64 IRF3 TLR3
25 cell-cell recognition GO:0009988 9.64 CD209 CLEC4M
26 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.63 ITGAV ITGB3
27 negative regulation of lipid transport GO:0032369 9.63 ITGAV ITGB3
28 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.62 ITGAV ITGB3
29 virion attachment to host cell GO:0019062 9.61 CD209 CLEC4M
30 MDA-5 signaling pathway GO:0039530 9.61 IFIH1 IRF3
31 peptide antigen transport GO:0046968 9.6 CD209 CLEC4M
32 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.59 DDX58 IFIH1
33 regulation of type III interferon production GO:0034344 9.58 DDX58 IFIH1
34 negative regulation of lipoprotein metabolic process GO:0050748 9.58 ITGAV ITGB3
35 innate immune response GO:0045087 9.44 CD209 CLEC4M DDX58 IFIH1 IFITM1 IFITM2
36 immune system process GO:0002376 10.07 CD209 CLEC4M DDX58 IFIH1 IFITM1 IRF3
37 viral process GO:0016032 10.06 CCR5 CD209 CLEC4M DDX58 IFIH1 IRF3

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 DDX58 IFIH1 IRF3 ITGB3 MX1 TLR3
2 mannose binding GO:0005537 9.49 CD209 CLEC4M
3 insulin-like growth factor I binding GO:0031994 9.48 ITGAV ITGB3
4 hydrolase activity, acting on acid anhydrides GO:0016817 9.46 DDX58 IFIH1
5 virion binding GO:0046790 9.4 CD209 CLEC4M
6 coreceptor activity GO:0015026 9.33 CCR5 ITGAV ITGB3
7 neuregulin binding GO:0038132 9.32 ITGAV ITGB3
8 C-X3-C chemokine binding GO:0019960 9.26 ITGAV ITGB3
9 double-stranded RNA binding GO:0003725 9.26 DDX58 IFIH1 OAS1 TLR3
10 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4M ITGAV ITGB3
11 protein binding GO:0005515 10.3 ABCF3 C19orf66 CCR5 CD209 DDX58 HELLS

Sources for West Nile Virus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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