MCID: WST005
MIFTS: 58

West Nile Virus

Categories: Genetic diseases, Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 53 72 49 40
West Nile Virus, Susceptibility to 53 28 13
Encephalitis, West Nile Fever 69
West Nile Viral Infection 69
Wnv, Susceptibility to 53
West-Nile Encephalitis 55
West Nile Fever 69
West-Nile Fever 55
Wnv 53

Characteristics:

Orphanet epidemiological data:

55
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

OMIM 53 610379
Orphanet 55 ORPHA83476
UMLS via Orphanet 70 C0751583 C0043124
ICD10 via Orphanet 33 A92.3
UMLS 69 C1096184

Summaries for West Nile Virus

MedlinePlus : 40 West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, health history and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to japanese encephalitis and rift valley fever, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Glycine and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotype is immune system.

OMIM : 53 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Wikipedia : 72 West Nile virus (WNV) is a... more...

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 japanese encephalitis 30.5 CD209 CLEC4M DDX58 TLR3
2 rift valley fever 30.1 CD209 IFITM3 MX1
3 encephalitis 30.0 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2
4 dengue virus 29.6 CD209 DDX58 EXOC1 IFIH1 IFITM2 IFITM3
5 severe acute respiratory syndrome 29.6 CD209 CLEC4M IFNA1 IRF3
6 tick-borne encephalitis 29.5 CCR5 CD209 OAS1 TLR3
7 hepatitis c 29.3 CLEC4M DDX58 IFNA1 IRF3 TLR3
8 measles 29.2 CD209 DDX58 IFIH1 IFNA1 TLR3
9 human immunodeficiency virus type 1 28.7 CCR5 CD209 CLEC4M IFNA1 IRF3 TLR3
10 hepatitis c virus 28.6 CCR5 CLEC4M DDX58 IFIH1 IFITM1 IRF3
11 influenza 27.7 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 MX1
12 west nile encephalitis 11.8
13 west nile fever 11.8
14 kunjin encephalitis 11.3
15 st. louis encephalitis 10.4
16 meningoencephalitis 10.4
17 chorioretinitis 10.4
18 meningitis 10.3
19 retinitis 10.2
20 poliomyelitis 10.2
21 neuronitis 10.2
22 coccidioidomycosis 10.1
23 vasculitis 10.1
24 singleton-merten syndrome 10.1 DDX58 IFIH1
25 ataxia and polyneuropathy, adult-onset 10.1
26 aging 10.1
27 aceruloplasminemia 10.1
28 ataxia-oculomotor apraxia 3 10.1
29 hepatitis 10.1
30 chikungunya 10.1
31 eastern equine encephalitis 10.1
32 murray valley encephalitis 10.1
33 retinal vasculitis 10.1
34 aseptic meningitis 10.1
35 blood group, i system 10.0
36 cataract 32, multiple types 10.0
37 malaria 10.0
38 hepatitis b 10.0
39 leukemia 10.0
40 choroiditis 10.0
41 crimean-congo hemorrhagic fever 10.0
42 quadriplegia 10.0
43 spinal cord disease 10.0
44 kidney disease 10.0
45 hemorrhagic fever 10.0
46 myoclonus 10.0
47 newcastle disease 10.0 DDX58 IFNA1 IRF3
48 myositis 9.8
49 polykaryocytosis inducer 9.8
50 myasthenia gravis 9.8

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pruritus, pain, headache, fever, back pain

MGI Mouse Phenotypes related to West Nile Virus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCR5 CFH CLEC4M DDX58 IFIH1 IFITM3

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Antibodies Phase 2,Phase 1
3 gamma-Globulins Phase 2,Phase 1
4 Immunoglobulins Phase 2,Phase 1
5 Immunoglobulins, Intravenous Phase 2,Phase 1
6 Rho(D) Immune Globulin Phase 2,Phase 1
7 Pharmaceutical Solutions Phase 1, Phase 2
8 Vaccines Phase 2,Phase 1
9 Antibodies, Monoclonal Phase 2,Phase 1
10
Aluminum sulfate Approved Phase 1 10043-01-3
11
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
12 Adjuvants, Immunologic Phase 1
13 Antacids Phase 1
14 Anti-Ulcer Agents Phase 1
15 Gastrointestinal Agents Phase 1

Interventional clinical trials:

(show all 24)

# Name Status NCT ID Phase Drugs
1 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801 Phase 4
2 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
3 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
4 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
5 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
6 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
7 Phase 1 Trial of Inactivated West Nile Virus Vaccine Completed NCT02337868 Phase 1
8 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
9 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
10 A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
11 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
12 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
13 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
14 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
15 Safety Study of HBV-002 West Nile Vaccine in Healthy Adults Completed NCT00707642 Phase 1
16 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1 AVI-4065 Injection
17 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
18 West Nile Virus Natural History Completed NCT00138463
19 Natural History of West Nile Virus Infection Completed NCT00069303
20 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166
21 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
22 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
23 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
24 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

# Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 28 CCR5

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

38
Brain, Testes, Spinal Cord, Skin, T Cells, B Cells, Kidney

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 808)
# Title Authors Year
1
Correction: An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors. ( 29389963 )
2018
2
Understanding Knowledge, Attitudes, and Behaviors Toward West Nile Virus Prevention: A Survey of High-Risk Adults in Maryland. ( 29336697 )
2018
3
Splenic macrophages are required for protective innate immunity against West Nile virus. ( 29408905 )
2018
4
Exposure to West Nile virus and tick-borne encephalitis virus in dogs in Spain. ( 29322674 )
2018
5
Experimental transmission of West Nile Virus and Rift Valley Fever Virus by Culex pipiens from Lebanon. ( 29324834 )
2018
6
Population genetic structure of the Culex pipiens (Diptera: Culicidae) complex, vectors of West Nile virus, in five habitats. ( 29301567 )
2018
7
Attenuation of West Nile Virus NS2B/NS3 Protease by Amino Terminal Copper and Nickel Binding (ATCUN) Peptides. ( 29301071 )
2018
8
Mosquito community influences West Nile virus seroprevalence in wild birds: implications for the risk of spillover into human populations. ( 29422507 )
2018
9
Increases in the competitive fitness of West Nile virus isolates after introduction into California. ( 29195094 )
2018
10
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2016. ( 29324725 )
2018
11
Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration. ( 29406280 )
2018
12
Mating behavior of the West Nile virus vector Culex pipiens - role of behavioral asymmetries. ( 29288628 )
2018
13
West Nile Virus and Usutu Virus Monitoring of Wild Birds in Germany. ( 29361762 )
2018
14
Nucleic Acid Amplification Test For Detection Of West Nile Virus Infection In Pakistani Blood Donors. ( 29330974 )
2017
15
West Nile virus meningitis in a patient with human immunodeficiency virus type 1 infection. ( 28831299 )
2017
16
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. ( 27795421 )
2017
17
Transmission of West Nile Virus Through a Hematopoietic Stem Cell Transplant. ( 29309636 )
2017
18
West Nile virus in Ontario, Canada: A twelve-year analysis of human case prevalence, mosquito surveillance, and climate data. ( 28829827 )
2017
19
The Degree of One Health Implementation in the West Nile Virus Integrated Surveillance in Northern Italy, 2016. ( 28929098 )
2017
20
A Snapshot Avian Surveillance Reveals West Nile Virus and Evidence of Wild Birds Participating in Toscana Virus Circulation. ( 28832259 )
2017
21
Zika virus infection confers protection against West Nile virus challenge in mice. ( 28928416 )
2017
22
A Mouse Model of West Nile Virus Infection. ( 29261232 )
2017
23
Spatial distribution of West Nile virus in humans and mosquitoes in Israel, 2000-2014. ( 28882664 )
2017
24
Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus. ( 27914931 )
2017
25
LOW PREVALENCE OF WEST NILE VIRUS ANTIBODIES IN SELECT NORTHERN CALIFORNIA OWL SPECIES (2007-2014). ( 29297801 )
2017
26
Characterizing environmental risk factors for West Nile virus in Quebec, Canada, using clinical data in humans and serology in pet dogs. ( 28835296 )
2017
27
Spectral and Hydrodynamic Analysis of West Nile Virus RNA-Protein Interactions by Multiwavelength Sedimentation Velocity in the Analytical Ultracentrifuge. ( 27977168 )
2017
28
STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease. ( 28927677 )
2017
29
Pre-clinical development of a hydrogen peroxide-inactivated West Nile virus vaccine. ( 27919629 )
2017
30
An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors. ( 28873423 )
2017
31
Encephalitis and Thalamic Injury From Neuroinvasive West Nile Virus in Children on Treatment for Acute Lymphoblastic Leukemia. ( 29398166 )
2017
32
MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection. ( 28077630 )
2017
33
Susceptibility and Antibody Response of the Laboratory Model Zebra Finch (Taeniopygia guttata) to West Nile Virus. ( 28045891 )
2017
34
VectorTesta8c West Nile Virus Antigen Assay in an Inhibition Platform as Field Screening Tool for Flavivirus Group-Specific Antibodies in Brazilian Equines. ( 28854109 )
2017
35
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5. ( 28659477 )
2017
36
West Nile virus (WNV) presenting as acute cerebellar ataxia in an immunocompetent patient. ( 28377090 )
2017
37
Syndromic surveillance for West Nile virus using raptors in rehabilitation. ( 29187187 )
2017
38
Application of replication-defective West Nile virus vector to non-flavivirus vaccine targets. ( 28925795 )
2017
39
A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4I930, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers. ( 28077583 )
2017
40
Detection of West Nile virus in six mosquito species in synchrony with seroconversion among sentinel chickens in India. ( 28061903 )
2017
41
A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses. ( 28062007 )
2017
42
Virulence determinants of West Nile virus: how can these be used for vaccine design? ( 28919920 )
2017
43
Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012. ( 27935796 )
2017
44
Extinction of West Nile virus by Favipiravir through lethal mutagenesis. ( 28848019 )
2017
45
Striking diflubenzuron resistance in Culex pipiens, the prime vector of West Nile Virus. ( 28916816 )
2017
46
The impact of weather and storm water management ponds on the transmission of West Nile virus. ( 28878963 )
2017
47
Exploring vector-borne infection ecology in multi-host communities: A case study of West Nile virus. ( 27986465 )
2017
48
Potential Reservoir and Associated Factors for West Nile Virus in Three Distinct Climatological Zones. ( 28873035 )
2017
49
First Serological Evidence of West Nile Virus in Horses and Dogs from Corsica Island, France. ( 28075236 )
2017
50
Comparison of assays for the detection of West Nile virus antibodies in equine serum after natural infection or vaccination. ( 28063471 )
2017

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh37 Chromosome 3, 46414947: 46414978

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CCR5 CD209 CFH DDX58 IFIH1 IFITM1
2
Show member pathways
13.17 CCR5 DDX58 IFITM1 IFITM2 IFITM3 IFNA1
3
Show member pathways
12.8 IFNA1 IRF3 ITGAV ITGB3 MX1 TLR3
4
Show member pathways
12.55 CD209 CLEC4M DDX58 IFIH1 IFNA1 IRF3
5 12.46 DDX58 IFIH1 IFNA1 IRF3 OAS1 RSAD2
6
Show member pathways
12.45 CCR5 DDX58 IFIH1 IFNA1 IRF3 TLR3
7
Show member pathways
12.25 DDX58 IFIH1 IRF3 TLR3
8
Show member pathways
12.1 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 IRF3
9 11.96 CD209 CLEC4M ITGAV ITGB3
10 11.95 DDX58 IFNA1 IRF3 OAS1 TLR3
11 11.8 CD209 ITGAV ITGB3
12 11.63 ITGAV ITGB3 TLR3
13
Show member pathways
11.43 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
14
Show member pathways
11.03 DDX58 IRF3 MX1 OAS1
15 10.89 ITGAV ITGB3
16 10.69 ITGAV ITGB3
17 10.59 ITGAV ITGB3

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 CCR5 CD209 ITGAV ITGB3 TLR3
2 ruffle membrane GO:0032587 9.5 DDX58 ITGAV ITGB3
3 filopodium membrane GO:0031527 9.37 ITGAV ITGB3
4 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 ITGAV ITGB3
5 alphav-beta3 integrin-HMGB1 complex GO:0035868 9.16 ITGAV ITGB3
6 alphav-beta3 integrin-PKCalpha complex GO:0035866 8.96 ITGAV ITGB3
7 integrin alphav-beta3 complex GO:0034683 8.62 ITGAV ITGB3

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.94 CCR5 IFNA1 MX1 TLR3
2 viral entry into host cell GO:0046718 9.87 CD209 CLEC4M ITGAV ITGB3
3 type I interferon signaling pathway GO:0060337 9.86 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
4 negative regulation of viral genome replication GO:0045071 9.85 IFITM1 IFITM2 IFITM3 MX1 OAS1 RSAD2
5 response to virus GO:0009615 9.81 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 MX1
6 negative regulation of type I interferon production GO:0032480 9.8 DDX58 IFIH1 IRF3
7 innate immune response GO:0045087 9.8 CD209 CFH CLEC4M DDX58 IFIH1 IFITM1
8 response to exogenous dsRNA GO:0043330 9.78 DDX58 IFNA1 IRF3 TLR3
9 response to interferon-gamma GO:0034341 9.75 IFITM1 IFITM2 IFITM3
10 negative regulation of viral entry into host cell GO:0046597 9.73 IFITM1 IFITM2 IFITM3
11 positive regulation of interferon-beta production GO:0032728 9.73 DDX58 IFIH1 IRF3 TLR3
12 cellular response to exogenous dsRNA GO:0071360 9.72 DDX58 IFIH1 TLR3
13 response to biotic stimulus GO:0009607 9.71 IFITM1 IFITM2 IFITM3
14 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 IFIH1 IRF3
15 apoptotic cell clearance GO:0043277 9.69 ITGAV ITGB3
16 response to interferon-alpha GO:0035455 9.69 IFITM1 IFITM2 IFITM3
17 cell-substrate adhesion GO:0031589 9.68 ITGAV ITGB3
18 cell adhesion mediated by integrin GO:0033627 9.68 ITGAV ITGB3
19 viral genome replication GO:0019079 9.68 CD209 CLEC4M
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.68 ITGAV ITGB3
21 negative regulation of lipid storage GO:0010888 9.67 ITGAV ITGB3
22 positive regulation of tumor necrosis factor secretion GO:1904469 9.67 DDX58 IFIH1
23 positive regulation of interferon-alpha secretion GO:1902741 9.67 DDX58 IFIH1
24 response to interferon-beta GO:0035456 9.67 IFITM1 IFITM2 IFITM3
25 modulation by virus of host morphology or physiology GO:0019048 9.66 CD209 CLEC4M
26 cell-cell recognition GO:0009988 9.66 CD209 CLEC4M
27 cellular response to dsRNA GO:0071359 9.65 IRF3 TLR3
28 positive regulation of response to cytokine stimulus GO:0060760 9.65 DDX58 IFIH1
29 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.65 ITGAV ITGB3
30 positive regulation of interferon-beta secretion GO:0035549 9.64 DDX58 IFIH1
31 negative regulation of lipid transport GO:0032369 9.63 ITGAV ITGB3
32 detection of virus GO:0009597 9.63 DDX58 IFIH1 TLR3
33 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.62 ITGAV ITGB3
34 virion attachment to host cell GO:0019062 9.62 CD209 CLEC4M
35 MDA-5 signaling pathway GO:0039530 9.61 IFIH1 IRF3
36 peptide antigen transport GO:0046968 9.61 CD209 CLEC4M
37 regulation of type III interferon production GO:0034344 9.6 DDX58 IFIH1
38 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.59 DDX58 IFIH1
39 negative regulation of lipoprotein metabolic process GO:0050748 9.58 ITGAV ITGB3
40 defense response to virus GO:0051607 9.4 DDX58 EXOC1 IFIH1 IFITM1 IFITM2 IFITM3
41 immune system process GO:0002376 10.1 CD209 CLEC4M DDX58 IFIH1 IFITM1 IRF3
42 viral process GO:0016032 10.06 CCR5 CD209 CFH CLEC4M DDX58 EXOC1

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mannose binding GO:0005537 9.43 CD209 CLEC4M
2 insulin-like growth factor I binding GO:0031994 9.4 ITGAV ITGB3
3 virion binding GO:0046790 9.37 CD209 CLEC4M
4 coreceptor activity GO:0015026 9.33 CCR5 ITGAV ITGB3
5 neuregulin binding GO:0038132 9.32 ITGAV ITGB3
6 C-X3-C chemokine binding GO:0019960 9.26 ITGAV ITGB3
7 double-stranded RNA binding GO:0003725 9.26 DDX58 IFIH1 OAS1 TLR3
8 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4M ITGAV ITGB3

Sources for West Nile Virus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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