MCID: WST002
MIFTS: 27

Western Equine Encephalitis

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Western Equine Encephalitis

MalaCards integrated aliases for Western Equine Encephalitis:

Name: Western Equine Encephalitis 12 50 56 14
Encephalomyelitis, Western Equine 42 69
Western Equine Encephalomyelitis 50 56
Wee 12 50

Characteristics:

Orphanet epidemiological data:

56
western equine encephalitis
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:10843
ICD10 33 A83.1
ICD9CM 35 062.1
MeSH 42 D020241
NCIt 47 C85227
SNOMED-CT 64 47523006
Orphanet 56 ORPHA83593
UMLS via Orphanet 70 C0153064
ICD10 via Orphanet 34 A83.1
UMLS 69 C0153064

Summaries for Western Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in brain of horses and humans, has material basis in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom anorexia, has symptom malaise, has symptom altered mental status, and has symptom weakness.

MalaCards based summary : Western Equine Encephalitis, also known as encephalomyelitis, western equine, is related to st. louis encephalitis and encephalitis. An important gene associated with Western Equine Encephalitis is KLHL41 (Kelch Like Family Member 41). The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include brain, testes and kidney.

Related Diseases for Western Equine Encephalitis

Diseases related to Western Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
id Related Disease Score Top Affiliating Genes
1 st. louis encephalitis 25.5 CES2 CRY2 EDIL3 ERF KLHL41 PDE4D
2 encephalitis 10.9
3 eastern equine encephalitis 10.0
4 poliomyelitis 9.9
5 neuronitis 9.9
6 sleep apnea 9.7
7 mumps 9.7
8 japanese encephalitis 9.7
9 rabies 9.7
10 myocarditis 9.7
11 influenza 9.7
12 herpes simplex 9.7
13 venezuelan equine encephalitis 9.7
14 herpes simplex encephalitis 9.7

Graphical network of the top 20 diseases related to Western Equine Encephalitis:



Diseases related to Western Equine Encephalitis

Symptoms & Phenotypes for Western Equine Encephalitis

Drugs & Therapeutics for Western Equine Encephalitis

Drugs for Western Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) Vaccine Recruiting NCT02466750 Phase 2
2 Western Equine Encephalitis Vaccine Completed NCT01159561 Phase 1

Search NIH Clinical Center for Western Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, western equine

Genetic Tests for Western Equine Encephalitis

Anatomical Context for Western Equine Encephalitis

MalaCards organs/tissues related to Western Equine Encephalitis:

39
Brain, Testes, Kidney, Skin

Publications for Western Equine Encephalitis

Articles related to Western Equine Encephalitis:

(show top 50) (show all 192)
id Title Authors Year
1
Susceptibility and Lethality of Western Equine Encephalitis Virus in Balb/c Mice When Infected by the Aerosol Route. ( 28654007 )
2017
2
Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses Using Reverse Transcription Loop-Mediated Isothermal Amplification. ( 26807734 )
2016
3
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. ( 27632563 )
2016
4
ENTRY SITES OF VENEZUELAN AND WESTERN EQUINE ENCEPHALITIS VIRUSES IN THE MOUSE CENTRAL NERVOUS SYSTEM FOLLOWING PERIPHERAL INFECTION. ( 27053560 )
2016
5
Evolutionary genetics and vector adaptation of recombinant viruses of the western equine encephalitis antigenic complex provides new insights into alphavirus diversity and host switching. ( 25463613 )
2015
6
Western equine encephalitis virus: evolutionary analysis of a declining alphavirus based on complete genome sequences. ( 24899192 )
2014
7
Human-like antibodies neutralizing Western equine encephalitis virus. ( 24518197 )
2014
8
Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo. ( 25031353 )
2014
9
Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development. ( 25361697 )
2014
10
Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid. ( 23192868 )
2013
11
Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus. ( 23544138 )
2013
12
Vector competence of five common mosquito species in the People's Republic of China for Western equine encephalitis virus. ( 22276651 )
2012
13
Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis. ( 23031498 )
2012
14
Evaluation of antiviral activity of aqueous extracts from Achyrocline satureioides against Western equine encephalitis virus. ( 20623427 )
2012
15
Fatal human case of Western equine encephalitis, Uruguay. ( 21529429 )
2011
16
Envelope protein E1 as vaccine target for western equine encephalitis virus. ( 21084062 )
2011
17
Factors affecting recombinant Western equine encephalitis virus glycoprotein production in the baculovirus system. ( 21864686 )
2011
18
Transmission potential of two chimeric western equine encephalitis vaccine candidates in Culex tarsalis. ( 20134017 )
2010
19
Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge. ( 20452378 )
2010
20
Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy. ( 20631130 )
2010
21
Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination. ( 19923571 )
2010
22
Effect of T-705 treatment on western equine encephalitis in a mouse model. ( 19428608 )
2009
23
Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus. ( 19446595 )
2009
24
Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. ( 19403754 )
2009
25
Functional pseudotyping of human immunodeficiency virus type 1 vectors by Western equine encephalitis virus envelope glycoprotein. ( 18842711 )
2008
26
Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence. ( 18801549 )
2008
27
Maturation-dependent responses of human neuronal cells to western equine encephalitis virus infection and type I interferons. ( 18022665 )
2008
28
Cloning, expression and purification of envelope proteins E1 and E2 of western equine encephalitis virus and potential use of them as antigens in immunoassays. ( 18054449 )
2008
29
Immunological evaluation of Escherichia coli expressed E2 protein of Western equine encephalitis virus. ( 17499379 )
2007
30
Complete protection of mice against a lethal dose challenge of western equine encephalitis virus after immunization with an adenovirus-vectored vaccine. ( 17467858 )
2007
31
Single-dose, fast-acting vaccine candidate against western equine encephalitis virus completely protects mice from intranasal challenge with different strains of the virus. ( 17630056 )
2007
32
Pre- and post-exposure protection against Western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha. ( 17761207 )
2007
33
Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model. ( 17118420 )
2007
34
Infectivity variation and genetic diversity among strains of Western equine encephalitis virus. ( 16847131 )
2006
35
Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques. ( 16136459 )
2005
36
Efficacy of DNA vaccination against western equine encephalitis virus infection. ( 15755611 )
2005
37
Evaluation of a Western Equine Encephalitis recombinant E1 protein for protective immunity and diagnostics. ( 15498603 )
2004
38
Development of a biotin mimic tagged ScFv antibody against western equine encephalitis virus: bacterial expression and refolding. ( 15041214 )
2004
39
Limited potential for mosquito transmission of genetically engineered, live-attenuated western equine encephalitis virus vaccine candidates. ( 12641414 )
2003
40
Detection of antibodies to alphaviruses and discrimination between antibodies to eastern and western equine encephalitis viruses in rabbit sera using a recombinant antigen and virus-specific monoclonal antibodies. ( 14628996 )
2003
41
Detection of North American eastern and western equine encephalitis viruses by nucleic acid amplification assays. ( 12517876 )
2003
42
Sensitivity of the VecTest antigen assay for eastern equine encephalitis and western equine encephalitis viruses. ( 14710752 )
2003
43
Pharmacokinetics study of a novel chimeric single-chain variable fragment antibody against western equine encephalitis virus. ( 11289221 )
2001
44
Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. ( 11515550 )
2001
45
Construction and characterization of a novel recombinant single-chain variable fragment antibody against Western equine encephalitis virus. ( 10768836 )
2000
46
Construction and characterization of monoclonal antibodies against western equine encephalitis virus. ( 10868791 )
2000
47
Complete genomic RNA sequence of western equine encephalitis virus and expression of the structural genes. ( 10640553 )
2000
48
Egg production drops in breeder turkeys associated with western equine encephalitis virus infection. ( 10216771 )
1999
49
A single chain Fv specific against Western equine encephalitis virus. ( 10571261 )
1999
50
Experimental infection of turkey poults with western equine encephalitis virus. ( 9356702 )
1997

Variations for Western Equine Encephalitis

Expression for Western Equine Encephalitis

Search GEO for disease gene expression data for Western Equine Encephalitis.

Pathways for Western Equine Encephalitis

GO Terms for Western Equine Encephalitis

Sources for Western Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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