WEE
MCID: WST002
MIFTS: 32

Western Equine Encephalitis (WEE) malady

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Western Equine Encephalitis

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Aliases & Descriptions for Western Equine Encephalitis:

Name: Western Equine Encephalitis 11 48 54 13
Encephalomyelitis, Western Equine 39 68
 
Western Equine Encephalomyelitis 48 54
Wee 11 48

Characteristics:

Orphanet epidemiological data:

54
western equine encephalitis:
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:10843
ICD1030 A83.1
ICD9CM32 062.1
MeSH39 D020241
SNOMED-CT62 47523006
NCIt45 C85227
Orphanet54 ORPHA83593
ICD10 via Orphanet31 A83.1

Summaries for Western Equine Encephalitis

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Disease Ontology:11 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Western equine encephalomyelitis virus, which is transmitted by Culex and transmitted by Aedes species of mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom anorexia, has symptom malaise, has symptom altered mental status, and has symptom weakness.

MalaCards based summary: Western Equine Encephalitis, also known as encephalomyelitis, western equine, is related to encephalitis and eastern equine encephalitis, and has symptoms including fever, headache and nausea. An important gene associated with Western Equine Encephalitis is KLHL41 (Kelch Like Family Member 41). Affiliated tissues include brain of horses, brain and testes.

Related Diseases for Western Equine Encephalitis

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Diseases related to Western Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis10.9
2eastern equine encephalitis10.0
3st. louis encephalitis9.9
4poliomyelitis9.9
5neuronitis9.9
6sleep apnea9.7
7mumps9.7
8japanese encephalitis9.7
9rabies9.7
10myocarditis9.7
11influenza9.7
12herpes simplex9.7
13venezuelan equine encephalitis9.7
14herpes simplex encephalitis9.7
15angiodysplasia of intestine8.8BRF1, CES2, CRY2, EDIL3, ERF, KLHL41

Graphical network of diseases related to Western Equine Encephalitis:



Diseases related to western equine encephalitis

Symptoms & Phenotypes for Western Equine Encephalitis

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Symptoms:

 11 (show all 8)
  • fever
  • headache
  • nausea
  • vomiting
  • anorexia
  • malaise
  • altered mental status
  • weakness

Drugs & Therapeutics for Western Equine Encephalitis

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Drugs for Western Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 2, Phase 16611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) VaccineRecruitingNCT02466750Phase 2
2Western Equine Encephalitis VaccineCompletedNCT01159561Phase 1

Search NIH Clinical Center for Western Equine Encephalitis


Cochrane evidence based reviews: encephalomyelitis, western equine

Genetic Tests for Western Equine Encephalitis

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Anatomical Context for Western Equine Encephalitis

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MalaCards organs/tissues related to Western Equine Encephalitis:

36
Brain, Testes, Kidney, Skin

FMA organs/tissues related to Western Equine Encephalitis:

17
Brain of horses

Publications for Western Equine Encephalitis

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Articles related to Western Equine Encephalitis:

(show top 50)    (show all 191)
idTitleAuthorsYear
1
ENTRY SITES OF VENEZUELAN AND WESTERN EQUINE ENCEPHALITIS VIRUSES IN THE MOUSE CENTRAL NERVOUS SYSTEM FOLLOWING PERIPHERAL INFECTION. (27053560)
2016
2
Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses Using Reverse Transcription Loop-Mediated Isothermal Amplification. (26807734)
2016
3
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. (27632563)
2016
4
Evolutionary genetics and vector adaptation of recombinant viruses of the western equine encephalitis antigenic complex provides new insights into alphavirus diversity and host switching. (25463613)
2015
5
Human-like antibodies neutralizing Western equine encephalitis virus. (24518197)
2014
6
Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development. (25361697)
2014
7
Western equine encephalitis virus: evolutionary analysis of a declining alphavirus based on complete genome sequences. (24899192)
2014
8
Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo. (25031353)
2014
9
Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus. (23544138)
2013
10
Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid. (23192868)
2013
11
Vector competence of five common mosquito species in the People's Republic of China for Western equine encephalitis virus. (22276651)
2012
12
Evaluation of antiviral activity of aqueous extracts from Achyrocline satureioides against Western equine encephalitis virus. (20623427)
2012
13
Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis. (23031498)
2012
14
Envelope protein E1 as vaccine target for western equine encephalitis virus. (21084062)
2011
15
Factors affecting recombinant Western equine encephalitis virus glycoprotein production in the baculovirus system. (21864686)
2011
16
Fatal human case of Western equine encephalitis, Uruguay. (21529429)
2011
17
Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy. (20631130)
2010
18
Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination. (19923571)
2010
19
Transmission potential of two chimeric western equine encephalitis vaccine candidates in Culex tarsalis. (20134017)
2010
20
Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge. (20452378)
2010
21
Effect of T-705 treatment on western equine encephalitis in a mouse model. (19428608)
2009
22
Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus. (19446595)
2009
23
Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. (19403754)
2009
24
Functional pseudotyping of human immunodeficiency virus type 1 vectors by Western equine encephalitis virus envelope glycoprotein. (18842711)
2008
25
Cloning, expression and purification of envelope proteins E1 and E2 of western equine encephalitis virus and potential use of them as antigens in immunoassays. (18054449)
2008
26
Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence. (18801549)
2008
27
Maturation-dependent responses of human neuronal cells to western equine encephalitis virus infection and type I interferons. (18022665)
2008
28
Immunological evaluation of Escherichia coli expressed E2 protein of Western equine encephalitis virus. (17499379)
2007
29
Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model. (17118420)
2007
30
Pre- and post-exposure protection against Western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha. (17761207)
2007
31
Complete protection of mice against a lethal dose challenge of western equine encephalitis virus after immunization with an adenovirus-vectored vaccine. (17467858)
2007
32
Single-dose, fast-acting vaccine candidate against western equine encephalitis virus completely protects mice from intranasal challenge with different strains of the virus. (17630056)
2007
33
Infectivity variation and genetic diversity among strains of Western equine encephalitis virus. (16847131)
2006
34
Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques. (16136459)
2005
35
Efficacy of DNA vaccination against western equine encephalitis virus infection. (15755611)
2005
36
Development of a biotin mimic tagged ScFv antibody against western equine encephalitis virus: bacterial expression and refolding. (15041214)
2004
37
Evaluation of a Western Equine Encephalitis recombinant E1 protein for protective immunity and diagnostics. (15498603)
2004
38
Detection of antibodies to alphaviruses and discrimination between antibodies to eastern and western equine encephalitis viruses in rabbit sera using a recombinant antigen and virus-specific monoclonal antibodies. (14628996)
2003
39
Detection of North American eastern and western equine encephalitis viruses by nucleic acid amplification assays. (12517876)
2003
40
Limited potential for mosquito transmission of genetically engineered, live-attenuated western equine encephalitis virus vaccine candidates. (12641414)
2003
41
Sensitivity of the VecTest antigen assay for eastern equine encephalitis and western equine encephalitis viruses. (14710752)
2003
42
Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. (11515550)
2001
43
Pharmacokinetics study of a novel chimeric single-chain variable fragment antibody against western equine encephalitis virus. (11289221)
2001
44
Construction and characterization of a novel recombinant single-chain variable fragment antibody against Western equine encephalitis virus. (10768836)
2000
45
Complete genomic RNA sequence of western equine encephalitis virus and expression of the structural genes. (10640553)
2000
46
Construction and characterization of monoclonal antibodies against western equine encephalitis virus. (10868791)
2000
47
Egg production drops in breeder turkeys associated with western equine encephalitis virus infection. (10216771)
1999
48
A single chain Fv specific against Western equine encephalitis virus. (10571261)
1999
49
Experimental infection of turkey poults with western equine encephalitis virus. (9356702)
1997
50
Western equine encephalitis virus in emus in Oklahoma. (7858032)
1994

Variations for Western Equine Encephalitis

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Expression for genes affiliated with Western Equine Encephalitis

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Search GEO for disease gene expression data for Western Equine Encephalitis.

Pathways for genes affiliated with Western Equine Encephalitis

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GO Terms for genes affiliated with Western Equine Encephalitis

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Sources for Western Equine Encephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet