Aliases & Classifications for Whiplash

MalaCards integrated aliases for Whiplash:

Name: Whiplash 50

Summaries for Whiplash

NINDS : 50 Whiplash-a soft tissue injury to the neck-is also called neck sprain or neck strain. It is characterized by a collection of symptoms that occur following damage to the neck, usually because of sudden extension and flexion. The disorder commonly occurs as the result of an automobile accident and may include injury to intervertebral joints, discs, and ligaments, cervical muscles, and nerve roots. Symptoms such as neck pain may be present directly after the injury or may be delayed for several days. In addition to neck pain, other symptoms may include neck stiffness, injuries to the muscles and ligaments (myofascial injuries), headache, dizziness, abnormal sensations such as burning or prickling (paresthesias), or shoulder or back pain. In addition, some people experience cognitive, somatic, or psychological conditions such as memory loss, concentration impairment, nervousness/irritability, sleep disturbances, fatigue, or depression.

MalaCards based summary : Whiplash is related to episodic pain syndrome, familial, 1 and cervicitis. An important gene associated with Whiplash is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Norepinephrine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and spinal cord.

Related Diseases for Whiplash

Diseases related to Whiplash via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 episodic pain syndrome, familial, 1 10.8
2 cervicitis 10.6
3 chronic pain 10.3
4 headache 10.2
5 omsk hemorrhagic fever 10.2 CCL4 CCL5
6 allergic hypersensitivity disease 10.2
7 avoidant personality disorder 10.2 CCL5 CCR5
8 yellow fever 10.2 CCL5 CCR5
9 acute cervicitis 10.2 CCL4 CCL5
10 oral lichen planus 10.2 CCL5 CCR5
11 pulmonary sarcoidosis 10.1 CCL5 CCR5
12 inclusion conjunctivitis 10.1 CCL5 IL16
13 viral meningitis 10.0 CCL5 IL16
14 blood group, i system 10.0
15 ring chromosome y syndrome 10.0
16 respiratory syncytial virus infectious disease 10.0 CCL3 CCL5
17 carney complex, type 1 9.9
18 central nervous system origin vertigo 9.9
19 aging 9.9
20 autoinflammation, lipodystrophy, and dermatosis syndrome 9.9 CCL3 CCL5
21 bronchiolitis 9.8 CCL3 CCL5
22 allergic asthma 9.8 CCL5 IL16
23 thoracic outlet syndrome 9.8
24 anxiety 9.8
25 cerebritis 9.8
26 radiculopathy 9.8
27 brain injury 9.8
28 traumatic brain injury 9.8
29 back pain 9.8
30 necatoriasis 9.8 CCL3 CCL4
31 trypanosomiasis 9.8 CCL3 CCL5
32 acquired immunodeficiency syndrome 9.7 CCL3 CCR5
33 encephalitis 9.7 CCL5 CCR5
34 chagas disease 9.7 CCL3 CCR5
35 acoustic neuroma 9.7
36 transient global amnesia 9.7
37 encephalopathy 9.7
38 benign paroxysmal positional nystagmus 9.7
39 head injury 9.7
40 migraine with or without aura 1 9.7
41 neuroma 9.7
42 post-traumatic stress disorder 9.7
43 occipital neuralgia 9.7
44 vertigo, benign recurrent 9.7
45 paine syndrome 9.7
46 neurogenic thoracic outlet syndrome 9.7
47 dermatitis 9.7
48 body mass index quantitative trait locus 1 9.7
49 toxic encephalopathy 9.7
50 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7

Graphical network of the top 20 diseases related to Whiplash:



Diseases related to Whiplash

Symptoms & Phenotypes for Whiplash

Drugs & Therapeutics for Whiplash

Drugs for Whiplash (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Citalopram Approved Phase 4 59729-33-8 2771
3 Central Nervous System Depressants Phase 4,Phase 2
4 Anesthetics Phase 4
5 Peripheral Nervous System Agents Phase 4,Phase 2
6
Serotonin Phase 4 50-67-9 5202
7 Adrenergic Agents Phase 4,Phase 2
8 Serotonin Agents Phase 4
9 Serotonin Uptake Inhibitors Phase 4
10 Muscarinic Antagonists Phase 4
11 Cholinergic Agents Phase 4
12 Cholinergic Antagonists Phase 4
13 Neurotransmitter Agents Phase 4,Phase 2
14 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
15 Parasympatholytics Phase 4
16 Antidepressive Agents Phase 4,Phase 2
17 Antidepressive Agents, Second-Generation Phase 4
18 Psychotropic Drugs Phase 4,Phase 2
19 Atomoxetine Hydrochloride Phase 4
20 Autonomic Agents Phase 4
21 Antiparkinson Agents Phase 4
22
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
23
Ethanol Approved Phase 2 64-17-5 702
24
Ibuprofen Approved Phase 2 15687-27-1 3672
25
Amitriptyline Approved Phase 2 50-48-6 2160
26
Cyclobenzaprine Approved Phase 2 303-53-7 2895
27
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
28 Analgesics Phase 2
29 Cortisol succinate Phase 2
30 Analgesics, Non-Narcotic Phase 2
31 Hydrocortisone 17-butyrate 21-propionate Phase 2
32 Hydrocortisone acetate Phase 2
33 Hydrocortisone-17-butyrate Phase 2
34 Anti-Inflammatory Agents Phase 2
35 Anti-Inflammatory Agents, Non-Steroidal Phase 2
36 Antirheumatic Agents Phase 2
37 Neuromuscular Agents Phase 2
38 Amitriptyline, perphenazine drug combination Phase 2
39 Tranquilizing Agents Phase 2
40 Cyclooxygenase Inhibitors Phase 2
41 Antidepressive Agents, Tricyclic Phase 2
42
Mannitol Approved, Investigational 69-65-8 6251 453
43
Triamcinolone Approved, Vet_approved 124-94-7 31307
44
Levobupivacaine Approved, Investigational 27262-47-1 92253
45 Pyrantel Approved, Vet_approved
46
Menthol Approved 2216-51-5 16666
47
Imidacloprid Vet_approved 105827-78-9 86418
48 triamcinolone acetonide
49 Triamcinolone diacetate
50 Triamcinolone hexacetonide

Interventional clinical trials:

(show all 48)

# Name Status NCT ID Phase Drugs
1 Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders Completed NCT01601912 Phase 4 Atomoxetine;Citalopram
2 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
3 Lidocaine Injection Versus Sham Needling in Treating Whiplash Associated Disorder Withdrawn NCT02060734 Phase 4
4 PEMF Effects on Pain After Abdominal Body Contouring Withdrawn NCT01762423 Phase 4
5 University Health Network Whiplash Intervention Trial Completed NCT00546806 Phase 3
6 Preventing Chronic Whiplash Pain Completed NCT00021476 Phase 3
7 Comparison of the Effect of Neck Collar, Act-as-Usual, and Active Mobilisation Early After a Whiplash Injury Completed NCT00206271 Phase 3
8 Manual Therapy Dosage Factorial Study Withdrawn NCT00560807 Phase 2, Phase 3
9 Association Between Low Cortisol Levels and Whiplash Syndrome Unknown status NCT02090309 Phase 2 Hydrocortisone;normal saline 0.9%
10 Does Acupuncture Activate Endogenous Pain Inhibition in Chronic Whiplash? Completed NCT01512576 Phase 2
11 Acupuncture for Whiplash Associated Disorder Completed NCT01395511 Phase 2
12 Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial Completed NCT00790270 Phase 2 Cyclobenzaprine;Ibuprofen;Ibuprofen plus Cyclobenzaprine
13 Tailored Computerized Mobilization of the Cervical Spine Utilizing the Occiflex Device for the Treatment of Chronic Neck Pain Completed NCT01518530 Phase 2
14 Whiplash-associated Disorders - Needling Treatments Pilot Study Unknown status NCT01824810
15 Is Chronic Whiplash-associated Pain of Neurogenic Origin? Unknown status NCT02692937
16 East-West Collaborative Medicine Using Bee-Venom Acupuncture on Whiplash-Associated Disorders Unknown status NCT01369238 zaltoprofen
17 Efficacy of Pain Neurophysiology Education in Combination With Psychologic Inoculation in Chronic Whiplash Unknown status NCT01544075 Early Phase 1
18 Treatment of Whiplash Associated Disorders by APOS Kit Unknown status NCT00266981
19 Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain Unknown status NCT01172795
20 A Clinical Comparison in Cervical Epidural Pressure Changes Between Midline and Paramedian Approaches Unknown status NCT01360138
21 Neuroscience Education on Osteoarthritis Unknown status NCT02246088
22 RFD Versus Cervical Medial Branch Blocks in Chronic Degenerative Neck Pain Unknown status NCT01743326
23 Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study Unknown status NCT00510757
24 Measuring the Impact of the French Version of the Whiplash Book Completed NCT03040245
25 Effects of Different Exercise Programs for People With Chronic Whiplash Associated Disorders Completed NCT01528579
26 Manual Therapy to Treat Acute Whiplash Injury Completed NCT01825460
27 Neck Muscle Activation in Patients With Long Standing Problems After a Whiplash Trauma Registered With Ultrasound With Speckle Tracking Completed NCT01547624
28 Randomized WAD Study Completed NCT01994044
29 Neck Exercises, Training and Pain Management as a Treatment for Whiplash Patients With Chronic Neck Pain Completed NCT01431261
30 Responses of People With Neck Pain Being Treated With Varying Doses of Manual Therapy: A Pilot Study Completed NCT01957033
31 Icing Effects on Neck Functions of the Boxers Completed NCT01203280
32 Explain Pain in Fibromyalgia Patients Completed NCT02474875
33 Pain Neuroscience Education Combined With Cognition-targeted Motor Control Training Completed NCT02098005
34 The Effect of TheraBand® Kinesiology Tape on Post-manipulation Pain and Range of Motion Completed NCT02691143
35 Why Does Acute Post Whiplash Injury Pain Transform Into Chronic Pain? Recruiting NCT02560675
36 Value-based Cognitive Behavioral Therapy for Prevention of Chronic Whiplash-associated Disorders Recruiting NCT02251028
37 Effectiveness of an Educational Video Following Acute Whiplash Trauma Recruiting NCT01699334
38 Investigating the Effect of an Information Video for Neck Injuries in a Emergency Department Setting Recruiting NCT02570659
39 Modern Pain Neuroscience Applied to Chronic Pain in Patients With Chronic Whiplash Associated Disorders Recruiting NCT03239938
40 Neck-specific Exercise in Chronic Whiplash Recruiting NCT03022812
41 Modeling Post-traumatic Pain and Recovery: The SYMBIOME Longitudinal Cohort Study Recruiting NCT02711085
42 Neuromuscular Mechanisms Underlying Poor Recovery From Whiplash Injuries Active, not recruiting NCT02157038 Early Phase 1
43 Free Fall Acrobatics to Reduce Neck Loads During Parachute Opening Shock: Evaluation of an Intervention. Enrolling by invitation NCT02625896
44 Correlation Between Central Sensitization Inventory and Posturographic Data Enrolling by invitation NCT03058003
45 Central Sensitization in Chronic Whiplash Patients Not yet recruiting NCT03005691
46 Influence of Beliefs on the Prognosis of Chronic Musculoskeletal Pain. Not yet recruiting NCT03036553
47 Maastricht Neck Study: Cervical Range of Motion in Whiplash Patients Terminated NCT00952510
48 Observational Study of the BrainScope® Ahead™ M-100 in UK Emergency Department Patients With Head Injury Terminated NCT01430988

Search NIH Clinical Center for Whiplash

Genetic Tests for Whiplash

Anatomical Context for Whiplash

MalaCards organs/tissues related to Whiplash:

38
Testes, Eye, Spinal Cord, Brain, Bone, Tongue, Skin

Publications for Whiplash

Articles related to Whiplash:

(show top 50) (show all 641)
# Title Authors Year
1
Reciprocal associations of pain and post-traumatic stress symptoms after whiplash injury: A longitudinal, cross-lagged study. ( 29377453 )
2018
2
Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion: A Finite Element Study. ( 29330341 )
2018
3
Long-term follow-up of whiplash injuries reported to insurance companies: a cohort study on patient-reported outcomes and impact of financial compensation. ( 29429037 )
2018
4
Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. ( 29343280 )
2018
5
Anthropometric characteristics and traffic accident circumstances of patients with isolated whiplash injury in University Clinical Hospital Mostar. ( 29214988 )
2018
6
Validity and test-retest reliability of the Dutch modified Perceived Deficits Questionnaire to examine cognitive symptoms in women with chronic whiplash, chronic idiopathic neck pain and fibromyalgia. ( 29383819 )
2018
7
The Discrepancy between Subjective and Objective Measures of Convergence Insufficiency in Whiplash-Associated Disorder versus Control Participants. ( 29371010 )
2018
8
Lateral atlantoaxial joint meniscoid volume in individuals with whiplash associated disorder: A case-control study. ( 29153925 )
2018
9
Toward Improving Outcomes in Whiplash: Implementing New Directions of Care. ( 28666399 )
2017
10
COMT genotype and non-recovery after a whiplash injury in a Northern European population. ( 29195501 )
2017
11
EXERCISE, MANUAL THERAPY AND POSTURAL RE-EDUCATION FOR UNCONTROLLED EAR TWITCHING AND RELATED IMPAIRMENTS AFTER WHIPLASH INJURY: A CASE REPORT. ( 29181262 )
2017
12
Evidence for cervical muscle morphometric changes on magnetic resonance images after whiplash: A systematic review and meta-analysis. ( 29269107 )
2017
13
Cost-effectiveness of neck-specific exercise with or without a behavioral approach versus physical activity prescription in the treatment of chronic whiplash-associated disorders: Analyses of a randomized clinical trial. ( 28640136 )
2017
14
Epidemiology and psychological factors of whiplash associated disorders in Japanese population. ( 28931977 )
2017
15
Predictors before and after multimodal rehabilitation for pain acceptance and engagement in activities at a 1-year follow-up for patients with whiplash-associated disorders (WAD)-a study based on the Swedish Quality Registry for Pain Rehabilitation (SQRP). ( 29155342 )
2017
16
Effects on jaw function shortly after whiplash trauma. ( 28891205 )
2017
17
Motor evoked potentials in patients with chronic whiplash-associated disorder grade II. ( 28711376 )
2017
18
Advancing imaging technologies for patients with spinal pain: with a focus on whiplash injury. ( 28774580 )
2017
19
Women with late whiplash syndrome have greatly reduced load-bearing of the cervical spine. In vivo biomechanical, cross-sectional, lateral radiographic study. ( 28714657 )
2017
20
Lack of Gender and Age Differences in Pain Measurements Following Exercise in People with Chronic Whiplash-Associated Disorders. ( 28934789 )
2017
21
Living with ongoing whiplash associated disorders: a qualitative study of individual perceptions and experiences. ( 29246144 )
2017
22
Persistent pseudomyopia following a whiplash injury in a previously emmetropic woman. ( 29260112 )
2017
23
Cross-sectional and Prospective Correlates of Recovery Expectancies in the Rehabilitation of Whiplash Injury. ( 28799973 )
2017
24
Whiplash Injury: Perspectives on the Development of Chronic Pain. ( 28759489 )
2017
25
Whiplash Syndrome- a disorder of the brain? ( 28697186 )
2017
26
Exercise induced hypoalgesia is elicited by isometric, but not aerobic exercise in individuals with chronic whiplash associated disorders. ( 28850338 )
2017
27
Management of Whiplash Associated Disorders in Australian general practice. ( 29284446 )
2017
28
Referral to specialist physiotherapists in the management of whiplash associated disorders: Perspectives of healthcare practitioners. ( 29220703 )
2017
29
The Whiplash Rash. ( 28761857 )
2017
30
Isometric muscle fatigue of the paravertebral and upper extremity muscles after whiplash injury. ( 28761029 )
2017
31
How Do We Meet the Challenge of Whiplash? ( 28666398 )
2017
32
The Qualitative Grading of Muscle Fat Infiltration in Whiplash Using Fat/Water Magnetic Resonance Imaging. ( 28887274 )
2017
33
Association between Clinical and Neurophysiological Outcomes in Patients with Mechanical Neck Pain and Whiplash-associated Disorders. ( 28678060 )
2017
34
Magnetic Resonance Imaging-Based Prediction of the Relationship between Whiplash Injury and Temporomandibular Disorders. ( 29375466 )
2017
35
Post-traumatic stress symptom clusters in acute whiplash associated disorder and their prediction of chronic pain-related disability. ( 29392244 )
2017
36
Neck-specific exercises with internet-based support compared to neck-specific exercises at a physiotherapy clinic for chronic whiplash-associated disorders: study protocol of a randomized controlled multicentre trial. ( 29233141 )
2017
37
Assessment of Range of Movement, Pain and Disability Following a Whiplash Injury. ( 28839498 )
2017
38
Decreased Regional Grey Matter Volume in Women with Chronic Whiplash-Associated Disorders: Relationships with Cognitive Deficits and Disturbed Pain Processing. ( 29149149 )
2017
39
Changes in Dorsal Neck Muscle Function in Individuals with Chronic Whiplash-Associated Disorders: A Real-Time Ultrasound Case-Control Study. ( 26921149 )
2016
40
Confirmatory factor analysis of the neck disability index, comparing patients with whiplash associated disorders to a control group with non-specific neck pain. ( 27040281 )
2016
41
An Investigation of Fat Infiltration of the Multifidus Muscle in Patients With Severe Neck Symptoms Associated With Chronic Whiplash Associated Disorder. ( 27590177 )
2016
42
Chronic Whiplash-Associated Disorders: Reorganization of the Brain? ( 27539066 )
2016
43
Satisfaction With the Outcome of Physical Therapist-Prescribed Exercise in Chronic Whiplash-Associated Disorders: Secondary Analysis of a Randomized Clinical Trial. ( 27374016 )
2016
44
Implementation of a guideline-based clinical pathway of care to improve health outcomes following whiplash injury (Whiplash ImPaCT): protocol of a randomised, controlled trial. ( 26996096 )
2016
45
Are People With Whiplash Associated Neck Pain Different to People With Non-Specific Neck Pain? ( 27594663 )
2016
46
The tongue after whiplash: case report and osteopathic treatment. ( 27462180 )
2016
47
Pharmacological and Interventional Management of Pain After Whiplash Injury. ( 27594660 )
2016
48
General practitioners knowledge and management of whiplash associated disorders and post-traumatic stress disorder: implications for patient care. ( 27440111 )
2016
49
Stressful events and coping related to acute and sub-acute whiplash-associated disorders. ( 26985631 )
2016
50
Economic and Health-Related Quality of Life Outcomes of Whiplash Associated Disorders. ( 26909831 )
2016

Variations for Whiplash

Expression for Whiplash

Search GEO for disease gene expression data for Whiplash.

Pathways for Whiplash

Pathways related to Whiplash according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 CCL3 CCL4 CCL5 CCR5 IL16
2
Show member pathways
13.27 CCL3 CCL4 CCL5 CCR5 IL16
3
Show member pathways
13.04 CCL3 CCL4 CCL5 CCR5 IL16
4
Show member pathways
12.94 CCL3 CCL4 CCL5 CCR5 IL16
5
Show member pathways
12.83 CCL3 CCL4 CCL5 CCR5 IL16
6
Show member pathways
12.53 CCL3 CCL4 CCL5 CCR5
7
Show member pathways
12.19 CCL3 CCL4 CCL5
8
Show member pathways
11.81 CCL3 CCL4 CCL5 CCR5
9
Show member pathways
11.55 CCL3 CCL4 CCR5
10 11.52 CCL3 CCL5
11 11.49 CCL3 CCL4
12
Show member pathways
11.32 CCL3 CCL4 CCL5 CCR5
13 11.23 CCL3 CCL4 CCL5
14
Show member pathways
11.07 CCL3 CCL4
15 10.69 CCL3 CCL4 CCL5 IL16
16 10.66 CCL3 CCL4 CCL5 IL16
17 10.61 CCL3 CCL4 CCL5 CCR5

GO Terms for Whiplash

Cellular components related to Whiplash according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CCL3 CCL4 CCL5 IL16 KNG1
2 extracellular space GO:0005615 9.02 CCL3 CCL4 CCL5 IL16 KNG1

Biological processes related to Whiplash according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.88 CCL3 CCL4 CCL5 IL16
2 positive regulation of GTPase activity GO:0043547 9.83 CCL3 CCL4 CCL5
3 MAPK cascade GO:0000165 9.81 CCL3 CCL5 CCR5
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 CCL3 CCL4 CCL5
5 immune response GO:0006955 9.8 CCL3 CCL4 CCL5 CCR5 IL16
6 calcium ion transport GO:0006816 9.79 CCL3 CCL5 CCR5
7 cell-cell signaling GO:0007267 9.78 CCL3 CCL4 CCL5 CCR5
8 cellular response to tumor necrosis factor GO:0071356 9.77 CCL3 CCL4 CCL5
9 response to toxic substance GO:0009636 9.72 CCL3 CCL4 CCL5
10 inflammatory response GO:0006954 9.72 CCL3 CCL4 CCL5 CCR5 KNG1
11 cellular response to interferon-gamma GO:0071346 9.71 CCL3 CCL4 CCL5
12 cellular calcium ion homeostasis GO:0006874 9.67 CCL3 CCL5
13 cellular response to interleukin-1 GO:0071347 9.67 CCL3 CCL4 CCL5
14 cellular response to organic cyclic compound GO:0071407 9.66 CCL3 CCL5
15 cell chemotaxis GO:0060326 9.66 CCL3 CCL5
16 calcium-mediated signaling GO:0019722 9.65 CCL3 CCR5
17 protein kinase B signaling GO:0043491 9.65 CCL3 CCL5
18 positive chemotaxis GO:0050918 9.64 CCL3 CCL5
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL3 CCL5
20 neutrophil chemotaxis GO:0030593 9.63 CCL3 CCL4 CCL5
21 positive regulation of calcium-mediated signaling GO:0050850 9.62 CCL3 CCL4
22 dendritic cell chemotaxis GO:0002407 9.62 CCL5 CCR5
23 macrophage chemotaxis GO:0048246 9.61 CCL3 CCL5
24 monocyte chemotaxis GO:0002548 9.61 CCL3 CCL4 CCL5
25 response to cholesterol GO:0070723 9.58 CCL3 CCR5
26 eosinophil chemotaxis GO:0048245 9.57 CCL3 CCL5
27 signaling GO:0023052 9.56 CCL3 CCR5
28 positive regulation of calcium ion transport GO:0051928 9.54 CCL3 CCL4 CCL5
29 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.52 CCL3 CCR5
30 negative regulation of macrophage apoptotic process GO:2000110 9.51 CCL5 CCR5
31 chemokine-mediated signaling pathway GO:0070098 9.46 CCL3 CCL4 CCL5 CCR5
32 negative regulation by host of viral transcription GO:0043922 9.43 CCL3 CCL4 CCL5
33 positive regulation of natural killer cell chemotaxis GO:2000503 9.13 CCL3 CCL4 CCL5
34 chemotaxis GO:0006935 9.02 CCL3 CCL4 CCL5 CCR5 IL16
35 G-protein coupled receptor signaling pathway GO:0007186 10 CCL3 CCL4 CCL5 CCR5 KNG1

Molecular functions related to Whiplash according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CCL3 CCL4 CCL5 IL16
2 chemokine activity GO:0008009 9.43 CCL3 CCL4 CCL5
3 chemoattractant activity GO:0042056 9.4 CCL3 CCL5
4 phosphatidylinositol phospholipase C activity GO:0004435 9.37 CCL5 CCR5
5 phospholipase activator activity GO:0016004 9.32 CCL3 CCL5
6 CCR5 chemokine receptor binding GO:0031730 9.13 CCL3 CCL4 CCL5
7 CCR1 chemokine receptor binding GO:0031726 8.8 CCL3 CCL4 CCL5

Sources for Whiplash

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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