MCID: WHP001
MIFTS: 40

Whipple Disease malady

Rare diseases, Neuronal diseases, Gastrointestinal diseases, Infectious diseases categories
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Summaries for Whipple Disease

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Sources:
43NIH Rare Diseases, 44NINDS, 33MalaCards
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NIH Rare Diseases:43 Whipple disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. the disorder usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. in the gastrointestinal system it interferes with the body's ability to absorb certain nutrients. this leads to a condition known as malabsorption. whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system. it is caused by infection from bacteria called tropheryma whippelii. when recognized and treated, whipple disease can usually be cured. untreated, the disease may be fatal. last updated: 8/1/2012

MalaCards: Whipple Disease, also known as intestinal lipodystrophy, is related to cerebritis and arthritis, and has symptoms including abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax, wasted (excluding lipodystrophy)/poorly muscled build/cachexy and impotence/painful erection/priapism/erection troubles. An important gene associated with Whipple Disease is DHPS (deoxyhypusine synthase). Affiliated tissues include eye, lung and brain.

NINDS:44 Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. The disorder can affect any system in the body, including the central nervous system, but usually occurs in the gastrointestinal system. Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain. Neurological symptoms may include abnormalities of eye and facial muscle movements, confusion, seizures, ataxia, memory loss, and vision impairment. Fever, cough, and joint soreness may also be present.

Aliases & Classifications for Whipple Disease

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 62UMLS, 44NINDS, 40NCIt, 27ICD9CM, 35MeSH, 58SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
intestinal lipodystrophy:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

whipple disease 8 43 49 62
intestinal lipodystrophy 8 43 44 49
intestinal lipophagic granulomatosis 43 49 62
secondary non-tropical sprue 43 49
whipple's disease 8 44
tropheryma whippelii infection 43


External Ids:

Disease Ontology8 DOID:8476
NCIt40 C85228
ICD9CM27 040.2
MeSH35 D008061
SNOMED-CT58 41545003
MESH via Orphanet36 C531849, D008061
ICD10 via Orphanet26 K90.8+, M14.8*
SNOMED-CT via Orphanet59 41545003
UMLS via Orphanet63 C0023788, C2930851

Related Diseases for Whipple Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Whipple Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1cerebritis10.2
2arthritis10.2
3hypertension10.1
4uveitis10.1
5giardiasis10.0
6panophthalmitis10.0
7posterior uveitis10.0
8adult-onset still's disease10.0
9amyloidosis10.0
10cerebellar ataxia10.0
11endocarditis10.0
12keratopathy10.0
13neuropathy10.0
14peripheral neuropathy10.0
15ataxia10.0
16hypersomnia10.0
17hypomagnesemia 1, intestinal10.0
18nephritis10.0

Graphical network of diseases related to Whipple Disease:



Diseases related to whipple disease

Symptoms for Whipple Disease

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49Orphanet
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Symptoms:

49 (show all 45)
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • impotence/painful erection/priapism/erection troubles
  • myocardium anomalies/myocarditis
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • myositis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • anorexia
  • hyponatremia
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • proptosis/exophthalmos
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • mediastinal/hilar adenopathies
  • edema of the legs/lower limbs
  • galactorrhea
  • insulin resistance
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • acute abdominal pain/colic
  • myalgia/muscular pain
  • cough
  • muscle weakness/flaccidity
  • psychic/psychomotor regression/dementia/intellectual decline
  • encephalitis
  • hydrocephaly
  • hypothyroidy
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • ataxia/incoordination/trouble of the equilibrium
  • hypotension
  • sleep and vigilance disorders
  • seizures/epilepsy/absences/spasms/status epilepticus
  • pyramidal syndrome
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • thoracic/chest pain
  • peripheral neuropathy
  • anaemia
  • articular/joint pain/arthralgia
  • fever/chilling
  • cranial nerves palsy
  • asthenia/fatigue/weakness
  • thirst
  • malabsorption/chronic diarrhea/steatorrhea
  • arthritis/synovitis/synovial proliferation
  • cranial hypertension
  • myoclonus/fasciculations

Drugs & Therapeutics for Whipple Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Whipple Disease

Search NIH Clinical Center for Whipple Disease

Genetic Tests for Whipple Disease

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Anatomical Context for Whipple Disease

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33MalaCards
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MalaCards organs/tissues related to Whipple Disease:

33
Eye, Lung, Brain, Heart, Skin, Liver, Spinal cord, B cells, Bone

Animal Models for Whipple Disease or affiliated genes

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Publications for Whipple Disease

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Sources:
52PubMed
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Articles related to Whipple Disease:

(show top 50)    (show all 87)
idTitleAuthorsYear
1
A severe Whipple disease with an immune reconstitution inflammatory syndrome: An additional case of thalidomide efficiency. (24289960)
2013
2
Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa. (23318851)
2013
3
Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases. (24187107)
2013
4
Whipple disease revealed by lung involvement: a case report and literature review. (22670021)
2012
5
Treated Whipple disease with erythema nodosum leprosum-like lesions: cutaneous PAS-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. (22123268)
2012
6
Whipple disease with crystalline keratopathy and chronic uveitis. (22965603)
2012
7
Whipple disease mimicking adult-onset Still's disease and treated by anakinra: diagnosis using PCR. (22639877)
2012
8
Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. (22743287)
2012
9
Peripheral neuropathy in Whipples disease: a case report. (22716061)
2012
10
Connecting the dots: the many systemic manifestations of whipple disease. (22347837)
2012
11
MR imaging of central nervous system Whipple disease: a 15-year review. (20395395)
2010
12
Primary cerebral Whipple disease presenting as KlA1ver-Bucy syndrome. (19139312)
2009
13
A paradoxical Tropheryma whipplei western blot differentiates patients with whipple disease from asymptomatic carriers. (19635029)
2009
14
Whipple disease: unusual presentation of a protean and sometimes confusing disease. (18538828)
2009
15
Postoperative panophthalmitis caused by Whipple disease. (19402983)
2009
16
Isolated Whipple disease of the brain resembling a tumour. (19194653)
2009
17
Reversible pulmonary hypertension in Whipple disease: a case report with clinicopathological implications, and literature review. (21686934)
2009
18
Whipple disease. (18301263)
2008
19
Teaching NeuroImage: Oculomasticatory myorhythmia: pathognomonic phenomenology of Whipple disease. (18250283)
2008
20
Exacerbation of Whipple disease by immunosuppressants. (18496383)
2008
21
Neurologically presenting Whipple disease: case report and review of the literature. (18381382)
2008
22
Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening. (18662136)
2008
23
Recurrent orbital inflammation and Whipple disease. (18379941)
2008
24
Isolated CNS Whipple disease with a variant of oculofacial-skeletal myorhythmia (OFSM). (17846404)
2007
25
Isolated CNS Whipple disease: acute onset and relapsing-remitting course. (17577831)
2007
26
Hypersomnia in Whipple disease: case report. (17057900)
2006
27
A case of Whipple disease with pleural effusion diagnosed by means of PCR. (17181935)
2006
28
Whipple disease: a case report and review of the literature. (15974820)
2005
29
Whipple disease associated with giardiasis. (12964113)
2003
30
Treatment of Whipple disease. (14973431)
2003
31
Intracerebral Whipple disease: unusual location and bone destruction. Case report. (12405392)
2002
32
Primary diagnosis of whipple disease manifesting as lymphadenopathy: use of polymerase chain reaction for detection of Tropheryma whippelii. (11764080)
2001
33
Tropheryma whippelii DNA is rare in the intestinal mucosa of patients without other evidence of Whipple disease. (11177314)
2001
34
An unusual spinal presentation of Whipple disease. (11337349)
2001
35
Culture and immunological detection of Tropheryma whippelii from the duodenum of a patient with Whipple disease. (11209175)
2001
36
Successful treatment of Whipple disease diagnosed 36 years after symptom onset. (11605693)
2001
37
Ocular manifestations of Whipple disease: an atypical presentation. (9747687)
1998
38
Treatment of refractory Whipple disease with interferon-gamma. (9867729)
1998
39
Diagnostic utility of the polymerase chain reaction in 2 cases of suspected Whipple disease. (9554687)
1998
40
Aortic valve endocarditis with Whipple disease. (9163306)
1997
41
Whipple disease confined to the central nervous system in childhood. (8883662)
1996
42
Detection of a clonal BCL2 gene rearrangement in tissues from a patient with Whipple disease. (8633834)
1996
43
MR of cerebral Whipple disease. (7545865)
1995
44
Whipple disease of the mediastinum. (1692443)
1990
45
The evolving natural history of neurologic involvement in Whipple disease: a hypothesis. (2456052)
1988
46
Mycobacterium avium-intracellulare complex enteritis: pseudo-Whipple disease in AIDS. (2580424)
1985
47
Computed tomography in Whipple disease. (6195202)
1983
48
Whipple disease of the nervous system. (6178057)
1982
49
Whipple disease. Occurrence in a 76-year-old man with a 20-year prodrome of arthritis. (48564)
1975
50
Whipple disease: light and electron microscopy study. (4138040)
1974

Variations for Whipple Disease

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Expression for genes affiliated with Whipple Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Whipple Disease

Search GEO for disease gene expression data for Whipple Disease.

Pathways for genes affiliated with Whipple Disease

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Compounds for genes affiliated with Whipple Disease

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GO Terms for genes affiliated with Whipple Disease

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Products for genes affiliated with Whipple Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Whipple Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet