MCID: WHP001
MIFTS: 48

Whipple Disease malady

Categories: Rare diseases, Neuronal diseases, Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Whipple Disease

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Whipple Disease:

Name: Whipple Disease 11 48 54 39 13 68
Intestinal Lipodystrophy 11 48 49 54
Intestinal Lipophagic Granulomatosis 48 54 68
Secondary Non-Tropical Sprue 48 54
 
Whipple's Disease 11 49
Tropheryma Whippelii Infection 48
Whipples Disease 50

Characteristics:

Orphanet epidemiological data:

54
whipple disease:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Italy); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:8476
ICD1030 K90.81
ICD9CM32 040.2
MeSH39 D008061
NCIt45 C85228
SNOMED-CT62 41545003
Orphanet54 ORPHA3452
ICD10 via Orphanet31 M14.8*, K90.8+
MESH via Orphanet40 C531849, D008061
UMLS via Orphanet69 C0023788, C2930851

Summaries for Whipple Disease

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NINDS:49 Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system. Neurological symptoms occur in up to 40 percent of individuals and may include dementia, abnormalities of eye and facial muscle movements, headaches, seizures, loss of muscle control, memory loss, weakness, and vision problems. Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain. Fever, cough, anemia, heart and lung damage, darkening of the skin, and joint soreness may also be present. The disease is more common in men and neurological symptoms are more common in individuals who have severe abdominal disease, Rarely, neurological symptoms may appear without gastrointestinal symptoms and can mimic symptoms of almost any neurologic disease.

MalaCards based summary: Whipple Disease, also known as intestinal lipodystrophy, is related to hypomagnesemia 1, intestinal and fruit allergy, and has symptoms including arthritis, malabsorption and abdominal pain. An important gene associated with Whipple Disease is IL16 (Interleukin 16), and among its related pathways are CTLA4 Signaling and Staphylococcus aureus infection. Affiliated tissues include lung, eye and brain.

NIH Rare Diseases:48 Whipple disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. The disorder usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. In the gastrointestinal system it interferes with the body's ability to absorb certain nutrients. This leads to a condition known as malabsorption. Whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system. It is caused by infection from bacteria called Tropheryma whippelii. When recognized and treated, Whipple disease can usually be cured. Untreated, the disease may be fatal. Last updated: 12/8/2015

Related Diseases for Whipple Disease

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Diseases related to Whipple Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1hypomagnesemia 1, intestinal10.8
2fruit allergy10.3HLA-DQB1, HLA-DRB1
3wolffian duct adenocarcinoma10.3HLA-DQB1, HLA-DRB1
4quinquaud's decalvans folliculitis10.3HLA-DQB1, HLA-DRB1
5parsonage turner syndrome10.3HLA-DQB1, HLA-DRB1
6pediatric systemic lupus erythematosus10.3HLA-DQB1, HLA-DRB1
7spastic paraplegia-paget disease of bone syndrome10.3CD58, HLA-DRB1
8myopathy-growth delay-intellectual disability-hypospadias syndrome10.3HLA-DQB1, HLA-DRB1
9vitreoretinochoroidopathy dominant10.3HLA-DQB1, HLA-DRB1
10krieble bixler syndrome10.3HLA-DQB1, HLA-DRB1
11spondylarthropathy10.3HLA-DQB1, HLA-DRB1
12mitochondrial encephalomyopathy10.3HLA-DQB1, HLA-DRB1
13ovarian papillary cystadenoma10.3HLA-DQB1, HLA-DRB1
14nebulin-related early-onset distal myopathy10.3HLA-DQB1, HLA-DRB1
15purpura fulminans10.3HLA-DQB1, HLA-DRB1
16lymphocytic colitis10.3HLA-DQB1, HLA-DRB1
17autoinflammation, lipodystrophy, and dermatosis syndrome10.3HLA-DQB1, HLA-DRB1
18peripheral t-cell lymphoma10.3HLA-DQB1, HLA-DRB1
19foster-kennedy syndrome10.3HLA-DQB1, HLA-DRB1
20thrombocytopenia due to platelet alloimmunization10.3HLA-DQB1, HLA-DRB1
21orbit alveolar rhabdomyosarcoma10.3HLA-DQB1, HLA-DRB1
22lipodermatosclerosis10.3HLA-DQB1, HLA-DRB1
23x-linked congenital generalized hypertrichosis10.3HLA-DQB1, HLA-DRB1
24aseptic osteitis10.3HLA-DQB1, HLA-DRB1
25idiopathic central precocious puberty10.2HLA-DQB1, HLA-DRB1
26oculogyric crisis10.2HLA-DQB1, HLA-DRB1
27sensorineural hearing loss10.2HLA-DQB1, HLA-DRB1
28mononeuritis of upper limb10.2HLA-DQB1, HLA-DRB1
29multicentric castleman disease10.2HLA-DQB1, HLA-DRB1
30hypoxia10.2HLA-DQB1, HLA-DRB1
31cirrhotic cardiomyopathy10.2HLA-DQB1, HLA-DRB1
32epidermolysis bullosa simplex superficialis10.2HLA-DQB1, HLA-DRB1
33achilles bursitis10.1HLA-DQB1, HLA-DRB1
34bile duct signet ring cell carcinoma10.1HLA-DRB1, HSPD1
35spinal atrophy ophthalmoplegia pyramidal syndrome10.1HLA-DQB1, HLA-DRB1
36conjunctival pigmentation10.1HLA-DQB1, HLA-DRB1
37breast carcinoma in situ10.0HLA-DQB1, HLA-DRB1
38intermittent proptosis10.0HLA-DRB1, IL16
39nephrosclerosis10.0HLA-DRB1, MRAP
40subcorneal pustular dermatosis10.0HLA-DQB1, HLA-DRB1
41iridocyclitis9.9HLA-DRB1, MRAP
42allergic hypersensitivity disease9.8HLA-DQB1, HLA-DRB1, MRAP
43pulmonary hypertension9.8
44arthritis9.8
45cerebritis9.8
46lethal midline granuloma9.7HLA-DQB1, HLA-DRB1
47uveitis9.7
48xanthomatosis9.7HLA-DRB1, MRAP
49cerebellar ataxia9.6
50keratopathy9.6

Graphical network of the top 20 diseases related to Whipple Disease:



Diseases related to whipple disease

Symptoms & Phenotypes for Whipple Disease

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Human phenotypes related to Whipple Disease:

 64 54 (show all 55)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis64 54 hallmark (90%) Very frequent (99-80%) HP:0001369
2 malabsorption64 54 hallmark (90%) Very frequent (99-80%) HP:0002024
3 abdominal pain64 54 hallmark (90%) Very frequent (99-80%) HP:0002027
4 anorexia64 54 hallmark (90%) Very frequent (99-80%) HP:0002039
5 developmental regression64 54 hallmark (90%) Very frequent (99-80%) HP:0002376
6 arthralgia64 54 hallmark (90%) Very frequent (99-80%) HP:0002829
7 involuntary movements64 hallmark (90%) HP:0004305
8 decreased body weight64 hallmark (90%) HP:0004325
9 abnormality of temperature regulation64 hallmark (90%) HP:0004370
10 mediastinal lymphadenopathy64 54 hallmark (90%) Very frequent (99-80%) HP:0100721
11 splenomegaly64 54 typical (50%) Frequent (79-30%) HP:0001744
12 abnormality of the pleura64 typical (50%) HP:0002103
13 hepatomegaly64 54 typical (50%) Frequent (79-30%) HP:0002240
14 sleep disturbance64 54 typical (50%) Frequent (79-30%) HP:0002360
15 hypotension64 54 typical (50%) Frequent (79-30%) HP:0002615
16 myalgia64 54 typical (50%) Frequent (79-30%) HP:0003326
17 inflammatory abnormality of the eye64 typical (50%) HP:0100533
18 hydrocephalus64 54 occasional (7.5%) Occasional (29-5%) HP:0000238
19 proptosis64 54 occasional (7.5%) Occasional (29-5%) HP:0000520
20 hypothyroidism64 54 occasional (7.5%) Occasional (29-5%) HP:0000821
21 insulin resistance64 54 occasional (7.5%) Occasional (29-5%) HP:0000855
22 seizures64 54 occasional (7.5%) Occasional (29-5%) HP:0001250
23 muscle weakness64 54 occasional (7.5%) Occasional (29-5%) HP:0001324
24 abnormality of the myocardium64 occasional (7.5%) HP:0001637
25 abnormality of the pericardium64 occasional (7.5%) HP:0001697
26 anemia64 54 occasional (7.5%) Occasional (29-5%) HP:0001903
27 respiratory insufficiency64 54 occasional (7.5%) Occasional (29-5%) HP:0002093
28 gastrointestinal hemorrhage64 54 occasional (7.5%) Occasional (29-5%) HP:0002239
29 incoordination64 occasional (7.5%) HP:0002311
30 encephalitis64 54 occasional (7.5%) Occasional (29-5%) HP:0002383
31 increased intracranial pressure64 54 occasional (7.5%) Occasional (29-5%) HP:0002516
32 hyponatremia64 54 occasional (7.5%) Occasional (29-5%) HP:0002902
33 cranial nerve paralysis64 54 occasional (7.5%) Occasional (29-5%) HP:0006824
34 abnormal pyramidal signs64 54 occasional (7.5%) Occasional (29-5%) HP:0007256
35 generalized hyperpigmentation64 54 occasional (7.5%) Occasional (29-5%) HP:0007440
36 peripheral neuropathy64 54 occasional (7.5%) Occasional (29-5%) HP:0009830
37 edema of the lower limbs64 54 occasional (7.5%) Occasional (29-5%) HP:0010741
38 myositis64 54 occasional (7.5%) Occasional (29-5%) HP:0100614
39 erectile abnormalities64 54 occasional (7.5%) Occasional (29-5%) HP:0100639
40 chest pain64 54 occasional (7.5%) Occasional (29-5%) HP:0100749
41 galactorrhea64 54 occasional (7.5%) Occasional (29-5%) HP:0100829
42 uveitis54 Frequent (79-30%)
43 depression54 Very frequent (99-80%)
44 ataxia54 Occasional (29-5%)
45 myoclonus54 Very frequent (99-80%)
46 myocardial infarction54 Occasional (29-5%)
47 pericarditis54 Occasional (29-5%)
48 fever54 Very frequent (99-80%)
49 polydipsia54 Occasional (29-5%)
50 diarrhea54 Very frequent (99-80%)
51 pleuritis54 Frequent (79-30%)
52 cachexia54 Very frequent (99-80%)
53 fatigue54 Very frequent (99-80%)
54 cough54 Occasional (29-5%)
55 myocarditis54 Occasional (29-5%)

UMLS symptoms related to Whipple Disease:


osler's node, sucrose intolerance

Drugs & Therapeutics for Whipple Disease

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Drugs for Whipple Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 72)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Secretinapproved, investigationalPhase 431108153-74-8
Synonyms:
108153-74-8
1393-25-5
67307-60-2 (citrate (salt))
9002-77-1
EINECS 215-733-3
Hormone of the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level
Human secretin
I06-1828
L-Histidyl-L-seryl-L-alpha-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-alpha-aspartyl-L-seryl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide
L-Histidyl-L-seryl-L-alpha-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-alpha-glutamylglycyl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide
LS-144747
RG 1068
SECREFLO
SECRETIN
SECRETIN-FERRING
 
SecreFlow
Secrepan
Secretin (human)
Secretin (porcine)
Secretin [INN:BAN:DCF:JAN]
Secretin-Kabi
Secretina
Secretina [INN-Spanish]
Secretine
Secretine [INN-French]
Secretinum
Secretinum [INN-Latin]
Secretolin
UNII-88C55N56UU
UNII-A0426J905J
Vitrum
2
Capecitabineapproved, investigationalPhase 41296154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
3Hormone AntagonistsPhase 412778
4Gastrointestinal AgentsPhase 4, Phase 28109
5Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
6HormonesPhase 413979
7AntimetabolitesPhase 4, Phase 211774
8Antimetabolites, AntineoplasticPhase 4, Phase 27171
9
PancrelipaseapprovedPhase 293553608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
10
Hydrocortisoneapproved, vet_approvedPhase 264050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
11
Cortisone acetateapprovedPhase 2651950-04-4, 50-04-45745
Synonyms:
 
Cortisyl
Cortone acetate
12
Morphineapproved, investigationalPhase 296057-27-25288826
Synonyms:
(-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(-)-Heroin hydrochloride
(-)-Morphine
(-)Morphine sulfate
(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol
(5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol
(5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5α,6α)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL
(7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
(−)-morphine
17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol
4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol
4-methyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol
47106-99-0
57-27-2
6211-15-0 (sulfate (2:1) (salt) pentahydrate)
64-31-3
64-31-3 (sulfate (2:1) (salt) anhydrous)
7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol
7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
8053-16-5
85201-37-2
Apokyn
Astramorph PF
Avinza
BIDD:GT0147
C01516
CCRIS 5762
CHEBI:17303
CHEMBL70
CID5288826
Cube juice
D-(-)-Morphine
DB00295
DEA No. 9300
DepoDur
Depodur
Diacetylmorphine hydrochloride
Diamorphine hydrochloride
Dolcontin
Dreamer
Dulcontin
Duramorph PF
Duromorph
EINECS 200-320-2
Epimorph
HSDB 2134
Hard stuff
Heroin hydrochloride
Heroine hydrochloride
Hocus
 
Infumorph
Kadian
LS-91748
M-Eslon
M.O.S
MOI
MORPHINE SULFATE
MORPHINE, (5A,6A)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINIAN-3,6-DIOL, MORPHIUM, MORPHIA, DOLCONTIN, DUROMORPH, MORPHINA, NEPENTHE
MS Contin
MS/L
MS/S
MSIR
Meconium
MolPort-003-849-273
Morfina
Morfina [Italian]
Morphia
Morphin
Morphin [German]
Morphina
Morphina [Italian]
Morphine Extra-Forte
Morphine Forte
Morphine H.P
Morphine Sulfate
Morphine [BAN]
Morphinism
Morphinum
Morphitec
Morphium
Morpho
Moscontin
Ms Contin
Ms Emma
NSC11441
Nepenthe
O,O'-Diacetylmorphine hydrochloride
OMS Concentrate
Oramorph SR
Ospalivina
RMS
RMS Uniserts
Rescudose
Roxanol
Roxanol 100
Roxanol UD
SDZ 202-250
SDZ202-250
Statex
Statex Drops
Statex SR
UNII-76I7G6D29C
Unkie
l-Morphine
morfina
morphine
nchembio.317-comp1
nchembio.64-comp1
13
Paclitaxelapproved, vet_approvedPhase 2275833069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
14
GemcitabineapprovedPhase 2197495058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
15
Irinotecanapproved, investigationalPhase 2108097682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
16
FluorouracilapprovedPhase 2179151-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
17
Fentanylapproved, illicit, investigational, vet_approvedPhase 2773437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
1-phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl CII
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
Fentanyl-12
Fentanyl-25
 
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidyl)propionanilide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenethyl-4-(N-propionylanilino)piperidine
N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl
18
butyric acidexperimentalPhase 2363107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
19pancreatinPhase 2935
20Analgesics, OpioidPhase 23091
21Anesthetics, IntravenousPhase 22406
22Anesthetics, GeneralPhase 22787
23AnestheticsPhase 29001
24Central Nervous System DepressantsPhase 212806
25AnalgesicsPhase 211287
26Peripheral Nervous System AgentsPhase 222776
27Hydrocortisone acetatePhase 2640
28Hydrocortisone-17-butyratePhase 2318
29Hydrocortisone 17-butyrate 21-propionatePhase 2640
30NarcoticsPhase 23486
31Anti-Inflammatory AgentsPhase 210355
32Cortisol succinatePhase 2640
33
CortisonePhase 26553-06-5222786
Synonyms:
Andreson
Anusol HC
Balneol-Hc
Colocort
Compound E
Corlin
Cortadren
Cortandren
Cortef
Cortef Acetate
Cortisal
Cortisate
Cortison
Cortisone Acetate
Cortistal
Cortivite
Cortogen
Cortone
Cortril
Dermacort
Dricort
Flexicort
 
Florinef
Fludrocortisone Acetate
Glycort
Hemsol-Hc
Hi-Cor
Incortin
Kendall'S Compound E
Kendall'S compound
Locoid
Locoid Lipocream
Micort-Hc
Nogenic HC
Orabase HCA
Pandel
Prestwick_132
Reichstein Fa
Reichstein'S Substance FA
Scheroson
Solu-Cortef
Stie-Cort
Texacort
Westcort
beta-Hc
34Anti-Infective AgentsPhase 221402
35Antiviral AgentsPhase 29732
36Protein Kinase InhibitorsPhase 23612
37Pharmaceutical SolutionsPhase 27793
38Albumin-Bound PaclitaxelPhase 22757
39Antimitotic AgentsPhase 25498
40topoisomerase I inhibitorsPhase 21328
41Topoisomerase InhibitorsPhase 24945
42Antineoplastic Agents, PhytogenicPhase 25420
43Imatinib MesylatePhase 2594123596
44Immunosuppressive AgentsPhase 212770
45Adjuvants, AnesthesiaPhase 21588
46KavanutraceuticalPhase 21489000-38-8
47
Somatostatinapproved22938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
48
Octreotideapproved, investigational21383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
49
Ketamineapproved, vet_approved5286740-88-13821
Synonyms:
(+-)-Ketamine
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-Ketamine
(-)-Ketamine
(S)-(-)-Ketamine
(S)-Ketamine
(±)-ketamine
100477-72-3
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
33643-45-7
6740-88-1
79499-51-7
AC1L1GSH
AC1Q40UR
AKOS001053247
BRN 2216965
C07525
C13H16ClNO
CHEBI:138833
CHEBI:6121
CHEMBL742
CI 581 base
CI-581
CID3821
CLSTA 20
Calypsol
Cetamina
Cetamina [INN-Spanish]
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
D08098
DB01221
DEA No. 7285
 
DL-ketamine
DivK1c_000217
EINECS 229-804-1
Esketamine
Green
IDI1_000217
KBio1_000217
KETAMINE
KETAMINE HCL
Ketaject
Ketalar
Ketalar base
Ketamina
Ketamine (INN)
Ketamine Base
Ketamine HCL
Ketamine [INN:BAN]
Ketaminum
Ketaminum [INN-Latin]
Ketanest
Ketoject
Ketolar
L-Ketamine
LS-57301
MLS001331674
MolPort-001-838-070
NCGC00159480-02
NCGC00159480-03
NINDS_000217
NMDA
NSC 70151
NSC70151
SMR000238141
Special K
Special K [street name]
Special k
T385
Tekam
Tekam (TN)
UNII-690G0D6V8H
dl-Ketamine
ketamine
l-Ketamine
50
Tramadolapproved, investigational23227203-92-533741
Synonyms:
(+)-(R,R)-trans-Tramadol
(+)-Tramadol
(+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol
(+)-trans-Tramadol free ba
(1R,2R)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
(1R,2R)-2-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
(1R,2R)-2-[(dimethylamino)methyl]-1-[3-(methyloxy)phenyl]cyclohexanol
27203-92-5
AC1L1Q6E
AC1Q59O2
AKOS005066335
Amanda
Amanda (TN)
BIDD:GT0075
C07153
CHEMBL1066
CID33741
Crispin
D08623
DB00193
EINECS 248-319-6
HMS2090D10
Jsp005295
LS-57115
 
LS-57116
MLS000333190
MolPort-002-507-778
NCGC00159343-02
Ralivia ER
Ralivia Flashtab
Ralivia flashtab
SMR000436547
STOCK4S-19075
Tradonal odis
Tramadol
Tramadol (INN)
Tramadol HCl
Tramadol HCl BP/EP
Tramadol [INN:BAN]
Tramadol hydrochloride
Tramadolum
Tramadolum [INN-Latin]
Tramal
Tramodol Hcl
Tridural
UNII-39J1LGJ30J
Ultram
Ultram ER
Zydol
tramadol

Interventional clinical trials:

(show all 44)
idNameStatusNCT IDPhase
1Efficacy of Secretin MRCP in the Diagnosis and Follow up of Auto Immune PancreatitisUnknown statusNCT01845467Phase 4
2Pharmacokinetic Study of Adjuvant Capecitabine After Resection of Pancreatic AdenocarcinomaCompletedNCT00854477Phase 4
3Pivotal Study of the FRED Stent System in the Treatment of Intracranial AneurysmsRecruitingNCT01801007Phase 2, Phase 3
4Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy (Whipple Operation)CompletedNCT01460615Phase 2
5HIPEC as Neoadjuvant Treatment for Resectable Pancreatic AdenocarcinomaRecruitingNCT02850874Phase 2
6Allogeneic Hematopoietic Stem Cell Transplantation in Pancreatic AdenocarcinomaRecruitingNCT02207985Phase 1, Phase 2
7Phase 2 Evaluation of Multi-modality Algorithm for Non-metastatic Adenocarcinoma of Pancreas or AmpullaRecruitingNCT02626520Phase 2
8The Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing PancreaticoduodenectomyRecruitingNCT01428050Phase 2
9Surgery for Locally Unresectable Advanced GISTs Without Metastasis After Imatinib TherapyRecruitingNCT01865565Phase 2
10Imaging of periOP Lung InjuryNot yet recruitingNCT02978885Phase 2
11Study to Explore Effectiveness of Sublingual Fentanyl Spray in Emergency Department Patients With Acute PainNot yet recruitingNCT02137525Phase 2
12The Size of the Gastric Remnant as Determinant for Delayed Gastric Emptying After Whipple Resection.TerminatedNCT02041052Phase 2
13Preoperative Stent StudyUnknown statusNCT00501176
14Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before PancreaticoduodenectomyUnknown statusNCT01913275
15Etiology, Assessment and Treatment of Post-gastric Bypass Severe HypoglycemiaUnknown statusNCT01865760
16Anastomotic Techniques in PancreaticoduodenectomyUnknown statusNCT00855985
17Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer SurgeryUnknown statusNCT02260128
18Mesenteric Traction Syndrome During Upper Gastrointestinal SurgeryCompletedNCT02507414
19The Prognostic Impact of Extracapsular Lymph Node Involvement in Ductal Pancreatic AdenocarcinomaCompletedNCT00644254
20Economisation of Whipple Resection Using an Ultrasonic Dissection DeviceCompletedNCT01321450
21Gastric Emptying After Infracolic or Supracolic Gastrojejunostomy Following PancreaticoduodenectomyCompletedNCT01191138
22Pancreatic Resection, Malnutrition and ReadmissionCompletedNCT01947166
23Reconstruction Following Pancreaticoduodenectomy: A Randomized Clinical Trial of Pancreaticojejunostomy vs PancreaticogastomyCompletedNCT00841607
24Abdominal Exploration Without IncisionsCompletedNCT00427752Early Phase 1
25Reconstruction Method and Delayed Gastric Emptying After Pancreatic SurgeryCompletedNCT01248663
26A Comparison Study Between Ketamine Versus Tramadol for Pain Management After Major Upper Abdominal SurgeryCompletedNCT02499341
27Chronic Infection With Tropheryma Whipplei: Risk Factors Related to the HostRecruitingNCT02868450
28GI Neuromuscular Pathology Prospective RegistryRecruitingNCT02165059
29Patient Centered Home Exercise Program for Peripheral Artery DiseaseRecruitingNCT02462824
30The PASTEC Study: Endoscopic Stenting Versus Surgery for the Treatment of Bile Duct Stricture in Chronic PancreatitisRecruitingNCT02366988
31Registry Study - Whipple at the Splenic ArteryRecruitingNCT01155882
32The Use of Wound Protector in Whipple's Procedure With Intrabiliary StentRecruitingNCT01836237
33Accelerated Recovery Pathway for Discharge After Surgery in Patients With Pancreatic CancerRecruitingNCT02517268
34EVIS - Ex-vivo Assessment of T-lymphocyte Homing in Primary Pancreatic CancerRecruitingNCT02695966
35Yttrium Y 90 Resin Microspheres Data Collection in Unresectable Liver Cancer: the RESIN StudyRecruitingNCT02685631
36Endoscopic Ultrasound Guided Radiofrequency Ablation (EUS-RFA) for Small Benign Pancreatic TumorsRecruitingNCT02882503
37Study of Intratumoral Hypoxia Using Pre-operative Administration of PimonidazoleRecruitingNCT01248637
38Neuroform Atlas IDE StudyRecruitingNCT02340585
39Outcomes in Minimally Invasive Versus Open PancreaticoduodenectomyEnrolling by invitationNCT02638818
40Whipple Procedure: Standard of Care vs. ThunderbeatEnrolling by invitationNCT02204124
41Clinical Trial of Pancreatic Cancer in Stockholm.Enrolling by invitationNCT02162823
42The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal SurgeryEnrolling by invitationNCT02381249
43The Effect of a Local Injection of a Platelet Concentrate on Infection and Healing of Surgical WoundsNot yet recruitingNCT02869204
44Initial Feasibility Study to Treat Pancreatic Cancer With a Planar LDR SourceNot yet recruitingNCT02843945

Search NIH Clinical Center for Whipple Disease


Cochrane evidence based reviews: whipple disease

Genetic Tests for Whipple Disease

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Anatomical Context for Whipple Disease

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MalaCards organs/tissues related to Whipple Disease:

36
Lung, Eye, Brain, Skin, Heart, Liver, Pancreas

Publications for Whipple Disease

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Articles related to Whipple Disease:

(show top 50)    (show all 102)
idTitleAuthorsYear
1
Pseudo-Whipple Disease Cutaneous Lesions. (27097339)
2016
2
Prosopagnosia as the Presenting Symptom of Whipple Disease. (27336807)
2016
3
Whipple disease confined to the central nervous system presenting as a cystic tumor: Case report and review of literature. (27593833)
2016
4
Deep Vein Thrombosis as Initial Manifestation of Whipple Disease. (27920655)
2016
5
Atypical presentation of Whipple disease with no diarrhea. (26275278)
2015
6
Gastrointestinal diagnosis of classical whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. (25881849)
2015
7
Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up. (26445540)
2015
8
Pulmonary hypertension associated with Whipple disease. (25445953)
2014
9
Bilateral panuveitis associated with Whipple disease - case report. (27625936)
2014
10
Specific cutaneous involvement in Whipple disease. (24562051)
2014
11
Neurocognitive impairment in Whipple disease with central nervous system involvement. (24674966)
2014
12
Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa. (23318851)
2013
13
Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases. (24187107)
2013
14
Oculomasticatory myorhythmia and agrypnia excitata guide the diagnosis of Whipple disease. (24210608)
2013
15
A severe Whipple disease with an immune reconstitution inflammatory syndrome: An additional case of thalidomide efficiency. (24289960)
2013
16
Monoclonal B-cell lymphocyte proliferation in a patient presenting with historical Whipple disease. (23441662)
2013
17
Resolution of Whipple Disease-Induced Pulmonary Hypertension Following Antibiotic Therapy. (23344104)
2013
18
Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up. (24145700)
2013
19
Whipple disease revealed by lung involvement: a case report and literature review. (22670021)
2012
20
Whipple disease with crystalline keratopathy and chronic uveitis. (22965603)
2012
21
Whipple disease mimicking adult-onset Still's disease and treated by anakinra: diagnosis using PCR. (22639877)
2012
22
A unique posterior segment manifestation of whipple disease. (25390964)
2012
23
Connecting the dots: the many systemic manifestations of whipple disease. (22347837)
2012
24
Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature. (23170246)
2012
25
Treated Whipple disease with erythema nodosum leprosum-like lesions: cutaneous PAS-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. (22123268)
2012
26
Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. (22743287)
2012
27
Peripheral neuropathy in Whipples disease: a case report. (22716061)
2012
28
Whipple disease research accelerates. (21628651)
2011
29
Whipple disease. (20224490)
2010
30
Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome. (19612977)
2010
31
Infection: How should classic Whipple disease be managed? (20442732)
2010
32
The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. (21135294)
2010
33
MR imaging of central nervous system Whipple disease: a 15-year review. (20395395)
2010
34
The amnesic syndrome of primary Whipple disease of the brain. (20299864)
2010
35
Intestinal Mycobacterium avium complex infection initially misdiagnosed and mistreated as Whipple disease. (20138615)
2010
36
Primary cerebral Whipple disease presenting as KlA1ver-Bucy syndrome. (19139312)
2009
37
A paradoxical Tropheryma whipplei western blot differentiates patients with whipple disease from asymptomatic carriers. (19635029)
2009
38
Postoperative panophthalmitis caused by Whipple disease. (19402983)
2009
39
Isolated Whipple disease of the brain resembling a tumour. (19194653)
2009
40
Reversible pulmonary hypertension in Whipple disease: a case report with clinicopathological implications, and literature review. (21686934)
2009
41
Renal amyloidosis in Whipple disease: a case report. (19918433)
2009
42
Whipple disease: unusual presentation of a protean and sometimes confusing disease. (18538828)
2009
43
Whipple disease. (18301263)
2008
44
Exacerbation of Whipple disease by immunosuppressants. (18496383)
2008
45
Recurrent orbital inflammation and Whipple disease. (18379941)
2008
46
Teaching NeuroImage: Oculomasticatory myorhythmia: pathognomonic phenomenology of Whipple disease. (18250283)
2008
47
Neurologically presenting Whipple disease: case report and review of the literature. (18381382)
2008
48
Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening. (18662136)
2008
49
Acquired resistance to trimethoprim-sulfamethoxazole during Whipple disease and expression of the causative target gene. (18500934)
2008
50
Isolated CNS Whipple disease: acute onset and relapsing-remitting course. (17577831)
2007

Variations for Whipple Disease

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Expression for genes affiliated with Whipple Disease

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Search GEO for disease gene expression data for Whipple Disease.

Pathways for genes affiliated with Whipple Disease

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Pathways related to Whipple Disease according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6HLA-DQB1, HLA-DRB1
29.6HLA-DQB1, HLA-DRB1
39.2CD58, HLA-DQB1, HLA-DRB1
49.2CD58, HLA-DQB1, HLA-DRB1
59.1HLA-DQB1, HLA-DRB1, HSPD1

GO Terms for genes affiliated with Whipple Disease

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Cellular components related to Whipple Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.2HLA-DQB1, HLA-DRB1
2endocytic vesicle membraneGO:003066610.2HLA-DQB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:001250710.2HLA-DQB1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.2HLA-DQB1, HLA-DRB1
5MHC class II protein complexGO:004261310.2HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:003258810.0HLA-DQB1, HLA-DRB1
7transport vesicle membraneGO:00306589.6HLA-DQB1, HLA-DRB1

Biological processes related to Whipple Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:006033310.1HLA-DQB1, HLA-DRB1
2inositol biosynthetic processGO:00060219.7IMPA2, ISYNA1
3inositol phosphate metabolic processGO:00436479.7IMPA2, ISYNA1
4T cell costimulationGO:00312959.6HLA-DQB1, HLA-DRB1

Molecular functions related to Whipple Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DQB1, HLA-DRB1

Sources for Whipple Disease

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet