MCID: WHP001
MIFTS: 49

Whipple Disease malady

Categories: Rare diseases, Neuronal diseases, Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Whipple Disease

Aliases & Descriptions for Whipple Disease:

Name: Whipple Disease 12 50 56 42 14 69
Intestinal Lipodystrophy 12 50 51 56
Intestinal Lipophagic Granulomatosis 50 56 69
Secondary Non-Tropical Sprue 50 56
Whipple's Disease 12 51
Tropheryma Whippelii Infection 50
Whipples Disease 52

Characteristics:

Orphanet epidemiological data:

56
whipple disease
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Italy); Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:8476
ICD10 33 K90.81
ICD9CM 35 040.2
MeSH 42 D008061
NCIt 47 C85228
SNOMED-CT 64 41545003
Orphanet 56 ORPHA3452
ICD10 via Orphanet 34 M14.8* K90.8+
MESH via Orphanet 43 C531849 D008061
UMLS via Orphanet 70 C0023788 C2930851
UMLS 69 C0023788

Summaries for Whipple Disease

NINDS : 51 Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system. Neurological symptoms occur in up to 40 percent of individuals and may include dementia, abnormalities of eye and facial muscle movements, headaches, seizures, loss of muscle control, memory loss, weakness, and vision problems. Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain. Fever, cough, anemia, heart and lung damage, darkening of the skin, and joint soreness may also be present. The disease is more common in men and neurological symptoms are more common in individuals who have severe abdominal disease, Rarely, neurological symptoms may appear without gastrointestinal symptoms and can mimic symptoms of almost any neurologic disease.

MalaCards based summary : Whipple Disease, also known as intestinal lipodystrophy, is related to hypomagnesemia 1, intestinal and apple allergy, and has symptoms including ataxia, arthralgia and fatigue. An important gene associated with Whipple Disease is IL16 (Interleukin 16), and among its related pathways/superpathways are Epstein-Barr virus infection and Tuberculosis. The drugs Secretin and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and heart.

NIH Rare Diseases : 50 whipple disease is an infectious bacterial disease that affects many different organ systems and interferes with the body's ability to metabolize fats. the disease usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. in the gastrointestinal system, it interferes with the body's ability to absorb certain nutrients. this leads to a condition known as malabsorption. whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system. it is caused by infection from bacteria called tropheryma whipplei (formerly called tropheryma whippelii). when recognized and treated, whipple disease can usually be cured. untreated, the disease may be fatal. last updated: 3/23/2017

Related Diseases for Whipple Disease

Diseases related to Whipple Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 hypomagnesemia 1, intestinal 10.8
2 apple allergy 10.2 HLA-DQB1 HLA-DRB1
3 hemoglobin d disease 10.2 HLA-DQB1 HLA-DRB1
4 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1
5 immune deficiency, familial variable 10.2 HLA-DQB1 HLA-DRB1
6 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
7 midline interhemispheric variant of holoprosencephaly 10.2 HLA-DQB1 HLA-DRB1
8 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 HLA-DRB1
9 renal agenesis meningomyelocele mullerian defect 10.2 HLA-DQB1 HLA-DRB1
10 lyme disease - neurological complications 10.2 HLA-DQB1 HLA-DRB1
11 distal trisomy 14q 10.2 HLA-DQB1 HLA-DRB1
12 learning disability 10.2 HLA-DQB1 HLA-DRB1
13 linear lichen planus 10.2 HLA-DQB1 HLA-DRB1
14 cervical adenoid basal carcinoma 10.2 HLA-DQB1 HLA-DRB1
15 neonatal antiphospholipid syndrome 10.1 HLA-DQB1 HLA-DRB1
16 clostridium difficile colitis 10.1 HLA-DQB1 HLA-DRB1
17 myofibroma 10.1 HLA-DQB1 HLA-DRB1
18 oromandibular dystonia 10.1 HLA-DQB1 HLA-DRB1
19 bickerstaff brainstem encephalitis 10.1 HLA-DQB1 HLA-DRB1
20 anaerobic meningitis 10.1 HLA-DQB1 HLA-DRB1
21 low anorectal malformation 10.1 HLA-DQB1 HLA-DRB1
22 ragweed sensitivity 10.1 HLA-DQB1 HLA-DRB1
23 pancreatic signet ring cell adenocarcinoma 10.1 HLA-DRB1 HSPD1
24 orofacial granulomatosis 10.1 CD58 HSPD1
25 folinic acid-responsive seizures 10.0 HLA-DQB1 HLA-DRB1
26 basilar artery occlusion 10.0 HSPD1 MRAP
27 lymphangiectasia, intestinal 10.0 HLA-DQB1 HLA-DRB1
28 anterior corneal pigmentation 10.0 HLA-DQB1 HLA-DRB1
29 premature menopause 10.0 HSPD1 MRAP
30 patau syndrome 10.0 HLA-DRB1 MRAP
31 choreatic disease 10.0 HLA-DQB1 HLA-DRB1
32 cryptococcosis 9.9 HLA-DQB1 HLA-DRB1 MRAP
33 parasitic helminthiasis infectious disease 9.9 HLA-DQB1 HLA-DRB1
34 intracranial hemorrhage in brain cerebrovascular malformations 9.9 HLA-DRB1 HSPD1 MRAP
35 pulmonary hypertension 9.8
36 arthritis 9.8
37 cerebritis 9.8
38 uveitis 9.7
39 cerebellar ataxia 9.5
40 keratopathy 9.5
41 thrombosis 9.5
42 endocarditis 9.5
43 giardiasis 9.5
44 spondyloarthropathy 9.5
45 panuveitis 9.5
46 posterior uveitis 9.5
47 diarrhea 9.5
48 panophthalmitis 9.5
49 adult-onset still's disease 9.5
50 prosopagnosia 9.5

Graphical network of the top 20 diseases related to Whipple Disease:



Diseases related to Whipple Disease

Symptoms & Phenotypes for Whipple Disease

Human phenotypes related to Whipple Disease:

56 32 (show all 47)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 56 32 Occasional (29-5%) HP:0001251
2 arthralgia 56 32 Very frequent (99-80%) HP:0002829
3 fatigue 56 32 Very frequent (99-80%) HP:0012378
4 myalgia 56 32 Frequent (79-30%) HP:0003326
5 cachexia 56 32 Very frequent (99-80%) HP:0004326
6 fever 56 32 Very frequent (99-80%) HP:0001945
7 seizures 56 32 Occasional (29-5%) HP:0001250
8 myoclonus 56 32 Very frequent (99-80%) HP:0001336
9 chest pain 56 32 Occasional (29-5%) HP:0100749
10 abdominal pain 56 32 Very frequent (99-80%) HP:0002027
11 diarrhea 56 32 Very frequent (99-80%) HP:0002014
12 muscle weakness 56 32 Occasional (29-5%) HP:0001324
13 polydipsia 56 32 Occasional (29-5%) HP:0001959
14 abnormal pyramidal signs 56 32 Occasional (29-5%) HP:0007256
15 hydrocephalus 56 32 Occasional (29-5%) HP:0000238
16 depression 56 32 Very frequent (99-80%) HP:0000716
17 hypothyroidism 56 32 Occasional (29-5%) HP:0000821
18 respiratory insufficiency 56 32 Occasional (29-5%) HP:0002093
19 sleep disturbance 56 32 Frequent (79-30%) HP:0002360
20 developmental regression 56 32 Very frequent (99-80%) HP:0002376
21 encephalitis 56 32 Occasional (29-5%) HP:0002383
22 hypotension 56 32 Frequent (79-30%) HP:0002615
23 arthritis 56 32 Very frequent (99-80%) HP:0001369
24 splenomegaly 56 32 Frequent (79-30%) HP:0001744
25 hepatomegaly 56 32 Frequent (79-30%) HP:0002240
26 increased intracranial pressure 56 32 Occasional (29-5%) HP:0002516
27 malabsorption 56 32 Very frequent (99-80%) HP:0002024
28 cranial nerve paralysis 56 32 Occasional (29-5%) HP:0006824
29 anemia 56 32 Occasional (29-5%) HP:0001903
30 myocardial infarction 56 32 Occasional (29-5%) HP:0001658
31 peripheral neuropathy 56 32 Occasional (29-5%) HP:0009830
32 anorexia 56 32 Very frequent (99-80%) HP:0002039
33 gastrointestinal hemorrhage 56 32 Occasional (29-5%) HP:0002239
34 hyponatremia 56 32 Occasional (29-5%) HP:0002902
35 pericarditis 56 32 Occasional (29-5%) HP:0001701
36 myocarditis 56 32 Occasional (29-5%) HP:0012819
37 cough 56 32 Occasional (29-5%) HP:0012735
38 erectile abnormalities 56 32 Occasional (29-5%) HP:0100639
39 proptosis 56 32 Occasional (29-5%) HP:0000520
40 mediastinal lymphadenopathy 56 32 Very frequent (99-80%) HP:0100721
41 generalized hyperpigmentation 56 32 Occasional (29-5%) HP:0007440
42 myositis 56 32 Occasional (29-5%) HP:0100614
43 edema of the lower limbs 56 32 Occasional (29-5%) HP:0010741
44 uveitis 56 32 Frequent (79-30%) HP:0000554
45 galactorrhea 56 32 Occasional (29-5%) HP:0100829
46 pleuritis 56 32 Frequent (79-30%) HP:0002102
47 insulin resistance 56 32 Occasional (29-5%) HP:0000855

Drugs & Therapeutics for Whipple Disease

Drugs for Whipple Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Secretin Approved, Investigational Phase 4 108153-74-8
2
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
3 Gastrointestinal Agents Phase 4,Phase 2
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Antimetabolites Phase 4,Phase 2
8 Antimetabolites, Antineoplastic Phase 4,Phase 2
9
Ethanol Approved Phase 3 64-17-5 702
10 Liver Extracts Phase 3
11
Pancrelipase Approved Phase 2 53608-75-6
12
Cortisone acetate Approved Phase 2 1950-04-4, 50-04-4 5745
13
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
14
Morphine Approved, Investigational Phase 2 57-27-2 5288826
15
Gemcitabine Approved Phase 2 95058-81-4 60750
16
Fluorouracil Approved Phase 2 51-21-8 3385
17
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
18
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
20
Butyric Acid Experimental Phase 2 107-92-6 264
21 Pharmaceutical Solutions Phase 2
22 pancreatin Phase 2
23 Anti-Inflammatory Agents Phase 2
24 Cortisol succinate Phase 2
25
Cortisone Phase 2 53-06-5 222786
26 Hydrocortisone 17-butyrate 21-propionate Phase 2
27 Hydrocortisone acetate Phase 2
28 Hydrocortisone-17-butyrate Phase 2
29 Analgesics Phase 2
30 Analgesics, Opioid Phase 2
31 Anesthetics Phase 2
32 Anesthetics, General Phase 2
33 Anesthetics, Intravenous Phase 2
34 Central Nervous System Depressants Phase 2
35 Narcotics Phase 2
36 Peripheral Nervous System Agents Phase 2
37 Anti-Infective Agents Phase 2
38 Antiviral Agents Phase 2
39 Immunosuppressive Agents Phase 2
40 Imatinib Mesylate Phase 2 123596
41 Protein Kinase Inhibitors Phase 2
42 Albumin-Bound Paclitaxel Phase 2
43 Antimitotic Agents Phase 2
44 Antineoplastic Agents, Phytogenic Phase 2
45 topoisomerase I inhibitors Phase 2
46 Topoisomerase Inhibitors Phase 2
47 Adjuvants, Anesthesia Phase 2
48 Kava Nutraceutical Phase 2 9000-38-8
49
Octreotide Approved, Investigational 83150-76-9 383414 6400441
50
Somatostatin Approved 38916-34-6, 51110-01-1 53481605

Interventional clinical trials:

(show all 46)
id Name Status NCT ID Phase
1 Efficacy of Secretin MRCP in the Diagnosis and Follow up of Auto Immune Pancreatitis Unknown status NCT01845467 Phase 4
2 Pharmacokinetic Study of Adjuvant Capecitabine After Resection of Pancreatic Adenocarcinoma Completed NCT00854477 Phase 4
3 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Recruiting NCT02612428 Phase 3
4 The Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01428050 Phase 2
5 Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy (Whipple Operation) Completed NCT01460615 Phase 2
6 HIPEC as Neoadjuvant Treatment for Resectable Pancreatic Adenocarcinoma Recruiting NCT02850874 Phase 2
7 Allogeneic Hematopoietic Stem Cell Transplantation in Pancreatic Adenocarcinoma Recruiting NCT02207985 Phase 1, Phase 2
8 Surgery for Locally Unresectable Advanced GISTs Without Metastasis After Imatinib Therapy Recruiting NCT01865565 Phase 2
9 Phase 2 Evaluation of Multi-modality Algorithm for Non-metastatic Adenocarcinoma of Pancreas or Ampulla Active, not recruiting NCT02626520 Phase 2
10 Imaging of periOP Lung Injury Not yet recruiting NCT02978885 Phase 2
11 Study to Explore Effectiveness of Sublingual Fentanyl Spray in Emergency Department Patients With Acute Pain Not yet recruiting NCT02137525 Phase 2
12 The Size of the Gastric Remnant as Determinant for Delayed Gastric Emptying After Whipple Resection. Terminated NCT02041052 Phase 2
13 Preoperative Stent Study Unknown status NCT00501176
14 Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before Pancreaticoduodenectomy Unknown status NCT01913275
15 Etiology, Assessment and Treatment of Post-gastric Bypass Severe Hypoglycemia Unknown status NCT01865760
16 Anastomotic Techniques in Pancreaticoduodenectomy Unknown status NCT00855985
17 Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer Surgery Unknown status NCT02260128
18 Mesenteric Traction Syndrome During Upper Gastrointestinal Surgery Completed NCT02507414
19 The Prognostic Impact of Extracapsular Lymph Node Involvement in Ductal Pancreatic Adenocarcinoma Completed NCT00644254
20 Economisation of Whipple Resection Using an Ultrasonic Dissection Device Completed NCT01321450
21 Gastric Emptying After Infracolic or Supracolic Gastrojejunostomy Following Pancreaticoduodenectomy Completed NCT01191138
22 Pancreatic Resection, Malnutrition and Readmission Completed NCT01947166
23 Reconstruction Following Pancreaticoduodenectomy: A Randomized Clinical Trial of Pancreaticojejunostomy vs Pancreaticogastomy Completed NCT00841607
24 Abdominal Exploration Without Incisions Completed NCT00427752 Early Phase 1
25 Reconstruction Method and Delayed Gastric Emptying After Pancreatic Surgery Completed NCT01248663
26 A Comparison Study Between Ketamine Versus Tramadol for Pain Management After Major Upper Abdominal Surgery Completed NCT02499341
27 Chronic Infection With Tropheryma Whipplei: Risk Factors Related to the Host Recruiting NCT02868450
28 Whipple Procedure: Standard of Care vs. Thunderbeat Recruiting NCT02204124
29 GI Neuromuscular Pathology Prospective Registry Recruiting NCT02165059
30 Patient Centered Home Exercise Program for Peripheral Artery Disease Recruiting NCT02462824
31 The PASTEC Study: Endoscopic Stenting Versus Surgery for the Treatment of Bile Duct Stricture in Chronic Pancreatitis Recruiting NCT02366988
32 Registry Study - Whipple at the Splenic Artery Recruiting NCT01155882
33 The Use of Wound Protector in Whipple's Procedure With Intrabiliary Stent Recruiting NCT01836237
34 Accelerated Recovery Pathway for Discharge After Surgery in Patients With Pancreatic Cancer Recruiting NCT02517268
35 EVIS - Ex-vivo Assessment of T-lymphocyte Homing in Primary Pancreatic Cancer Recruiting NCT02695966
36 Yttrium Y 90 Resin Microspheres Data Collection in Unresectable Liver Cancer: the RESIN Study Recruiting NCT02685631
37 Endoscopic Ultrasound Guided Radiofrequency Ablation (EUS-RFA) for Small Benign Pancreatic Tumors Recruiting NCT02882503
38 Study of Intratumoral Hypoxia Using Pre-operative Administration of Pimonidazole Recruiting NCT01248637
39 Neuroform Atlas IDE Study Recruiting NCT02340585
40 Outcomes in Minimally Invasive Versus Open Pancreaticoduodenectomy Enrolling by invitation NCT02638818
41 Clinical Trial of Pancreatic Cancer in Stockholm. Enrolling by invitation NCT02162823
42 The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery Enrolling by invitation NCT02381249
43 The Effect of a Local Injection of a Platelet Concentrate on Infection and Healing of Surgical Wounds Not yet recruiting NCT02869204
44 Trial of Omental Roll-up Technique on Pancreato-jejunostomy Anastomosis for Reducing Perioperative Complication in Patients Undergoing Pancreatoduodenectomy Not yet recruiting NCT03083938
45 Initial Feasibility Study to Treat Pancreatic Cancer With a Planar LDR Source Not yet recruiting NCT02843945
46 Initial Feasibility Study to Treat Resectable Pancreatic Cancer With a Planar LDR Source Not yet recruiting NCT03109041

Search NIH Clinical Center for Whipple Disease

Cochrane evidence based reviews: whipple disease

Genetic Tests for Whipple Disease

Anatomical Context for Whipple Disease

MalaCards organs/tissues related to Whipple Disease:

39
Brain, Lung, Heart, Eye, Skin, Spinal Cord, B Cells

Publications for Whipple Disease

Articles related to Whipple Disease:

(show top 50) (show all 104)
id Title Authors Year
1
Ultrastructural changes of small intestine in Whipple disease patient. ( 28230475 )
2017
2
Genotypic analysis of Tropheryma whipplei from patients with Whipple disease in the Americas. ( 28385924 )
2017
3
Pseudo-Whipple Disease Cutaneous Lesions. ( 27097339 )
2016
4
Deep Vein Thrombosis as Initial Manifestation of Whipple Disease. ( 27920655 )
2016
5
Prosopagnosia as the Presenting Symptom of Whipple Disease. ( 27336807 )
2016
6
Whipple disease confined to the central nervous system presenting as a cystic tumor: Case report and review of literature. ( 27593833 )
2016
7
Gastrointestinal diagnosis of classical whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. ( 25881849 )
2015
8
Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up. ( 26445540 )
2015
9
Atypical presentation of Whipple disease with no diarrhea. ( 26275278 )
2015
10
Pulmonary hypertension associated with Whipple disease. ( 25445953 )
2014
11
Specific cutaneous involvement in Whipple disease. ( 24562051 )
2014
12
Neurocognitive impairment in Whipple disease with central nervous system involvement. ( 24674966 )
2014
13
Bilateral panuveitis associated with Whipple disease - case report. ( 27625936 )
2014
14
Resolution of Whipple Disease-Induced Pulmonary Hypertension Following Antibiotic Therapy. ( 23344104 )
2013
15
Monoclonal B-cell lymphocyte proliferation in a patient presenting with historical Whipple disease. ( 23441662 )
2013
16
Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa. ( 23318851 )
2013
17
A severe Whipple disease with an immune reconstitution inflammatory syndrome: An additional case of thalidomide efficiency. ( 24289960 )
2013
18
Oculomasticatory myorhythmia and agrypnia excitata guide the diagnosis of Whipple disease. ( 24210608 )
2013
19
Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases. ( 24187107 )
2013
20
Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up. ( 24145700 )
2013
21
Whipple disease revealed by lung involvement: a case report and literature review. ( 22670021 )
2012
22
Whipple disease with crystalline keratopathy and chronic uveitis. ( 22965603 )
2012
23
Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature. ( 23170246 )
2012
24
Whipple disease mimicking adult-onset Still's disease and treated by anakinra: diagnosis using PCR. ( 22639877 )
2012
25
Treated Whipple disease with erythema nodosum leprosum-like lesions: cutaneous PAS-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. ( 22123268 )
2012
26
Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. ( 22743287 )
2012
27
Peripheral neuropathy in Whipples disease: a case report. ( 22716061 )
2012
28
Connecting the dots: the many systemic manifestations of whipple disease. ( 22347837 )
2012
29
A unique posterior segment manifestation of whipple disease. ( 25390964 )
2012
30
Whipple disease research accelerates. ( 21628651 )
2011
31
Intestinal Mycobacterium avium complex infection initially misdiagnosed and mistreated as Whipple disease. ( 20138615 )
2010
32
The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. ( 21135294 )
2010
33
Whipple disease. ( 20224490 )
2010
34
Infection: How should classic Whipple disease be managed? ( 20442732 )
2010
35
Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome. ( 19612977 )
2010
36
MR imaging of central nervous system Whipple disease: a 15-year review. ( 20395395 )
2010
37
The amnesic syndrome of primary Whipple disease of the brain. ( 20299864 )
2010
38
A paradoxical Tropheryma whipplei western blot differentiates patients with whipple disease from asymptomatic carriers. ( 19635029 )
2009
39
Renal amyloidosis in Whipple disease: a case report. ( 19918433 )
2009
40
Whipple disease: unusual presentation of a protean and sometimes confusing disease. ( 18538828 )
2009
41
Isolated Whipple disease of the brain resembling a tumour. ( 19194653 )
2009
42
Reversible pulmonary hypertension in Whipple disease: a case report with clinicopathological implications, and literature review. ( 21686934 )
2009
43
Postoperative panophthalmitis caused by Whipple disease. ( 19402983 )
2009
44
Primary cerebral Whipple disease presenting as KlA1ver-Bucy syndrome. ( 19139312 )
2009
45
Exacerbation of Whipple disease by immunosuppressants. ( 18496383 )
2008
46
Whipple disease. ( 18301263 )
2008
47
Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening. ( 18662136 )
2008
48
Recurrent orbital inflammation and Whipple disease. ( 18379941 )
2008
49
Neurologically presenting Whipple disease: case report and review of the literature. ( 18381382 )
2008
50
Acquired resistance to trimethoprim-sulfamethoxazole during Whipple disease and expression of the causative target gene. ( 18500934 )
2008

Variations for Whipple Disease

Expression for Whipple Disease

Search GEO for disease gene expression data for Whipple Disease.

Pathways for Whipple Disease

Pathways related to Whipple Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.64 CD58 HLA-DQB1 HLA-DRB1
2 11.38 HLA-DQB1 HLA-DRB1 HSPD1
3 11.17 HLA-DQB1 HLA-DRB1
4 11 HLA-DQB1 HLA-DRB1
5 10.96 CD58 HLA-DQB1 HLA-DRB1

GO Terms for Whipple Disease

Cellular components related to Whipple Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
6 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Whipple Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.63 HLA-DRB1 HSPD1 IL16
2 T cell costimulation GO:0031295 9.43 HLA-DQB1 HLA-DRB1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.4 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation GO:0019882 9.37 HLA-DQB1 HLA-DRB1
5 inositol phosphate metabolic process GO:0043647 9.32 IMPA2 ISYNA1
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
8 inositol biosynthetic process GO:0006021 8.96 IMPA2 ISYNA1
9 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Whipple Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Whipple Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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