SSA
MCID: WLD005
MIFTS: 22

Wild Type Attr Amyloidosis (SSA) malady

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Wild Type Attr Amyloidosis

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Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Wild Type Attr Amyloidosis:

Name: Wild Type Attr Amyloidosis 54
Senile Systemic Amyloidosis 54 68
Wild Type Attr-Related Amyloidosis 54
 
Attrwt-Related Amyloidosis 54
Attrwt Amyloidosis 54
Ssa 54

Characteristics:

Orphanet epidemiological data:

54
senile systemic amyloidosis:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Orphanet54 ORPHA330001
ICD10 via Orphanet31 E85.8

Summaries for Wild Type Attr Amyloidosis

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MalaCards based summary: Wild Type Attr Amyloidosis, also known as senile systemic amyloidosis, is related to amyloidosis, hereditary, transthyretin-related and lupus erythematosus, and has symptoms including Array, Array and Array. Affiliated tissues include heart and bone.

Related Diseases for Wild Type Attr Amyloidosis

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Graphical network of the top 20 diseases related to Wild Type Attr Amyloidosis:



Diseases related to wild type attr amyloidosis

Symptoms & Phenotypes for Wild Type Attr Amyloidosis

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Human phenotypes related to Wild Type Attr Amyloidosis:

 54 64 (show all 25)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency64 54 Occasional (29-5%) HP:0000083
2 proteinuria64 54 Occasional (29-5%) HP:0000093
3 nephrotic syndrome64 54 Occasional (29-5%) HP:0000100
4 nephropathy64 54 Occasional (29-5%) HP:0000112
5 hepatomegaly64 54 Frequent (79-30%) HP:0002240
6 congestive heart failure64 54 Very frequent (99-80%) HP:0001635
7 hypertrophic cardiomyopathy64 54 Very frequent (99-80%) HP:0001639
8 myocardial infarction64 54 Very frequent (99-80%) HP:0001658
9 bradycardia64 54 Occasional (29-5%) HP:0001662
10 weight loss64 54 Occasional (29-5%) HP:0001824
11 chronic diarrhea64 54 Frequent (79-30%) HP:0002028
12 pleural effusion64 54 Very frequent (99-80%) HP:0002202
13 intermittent diarrhea64 54 Frequent (79-30%) HP:0002254
14 autonomic dysregulation64 54 Frequent (79-30%) HP:0002271
15 gastrointestinal dysmotility64 54 Frequent (79-30%) HP:0002579
16 bowel incontinence64 54 Frequent (79-30%) HP:0002607
17 elevated alkaline phosphatase64 54 Frequent (79-30%) HP:0003155
18 abnormal ekg64 54 Very frequent (99-80%) HP:0003115
19 arrhythmia54 Frequent (79-30%)
20 orthostatic hypotension due to autonomic dysfunction64 54 Frequent (79-30%) HP:0004926
21 autonomic bladder dysfunction64 54 Frequent (79-30%) HP:0005341
22 interstitial pulmonary disease54 Very frequent (99-80%)
23 edema of the lower limbs64 54 Very frequent (99-80%) HP:0010741
24 pulmonary edema64 54 Very frequent (99-80%) HP:0100598
25 interstitial pulmonary abnormality64 HP:0006530

Drugs & Therapeutics for Wild Type Attr Amyloidosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyRecruitingNCT02791230Phase 3
2Safety And Efficacy Evaluation Of Fx-1006a In Patients With V122i Or Wild-Type Transthyretin (TTR) Amyloid CardiomyopathyActive, not recruitingNCT00935012Phase 3
3Safety and Efficacy of Tafamidis in Patients With Transthyretin CardiomyopathyActive, not recruitingNCT01994889Phase 3
4The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid CardiomyopathyCompletedNCT00694161Phase 2
5The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin AmyloidosisCompletedNCT00630864Phase 2
6The Effect of an Antisense Oligonucleotide to Lower Transthyretin (TTR) Levels on the Progression of -Wild-type TTR Involving the HeartWithdrawnNCT02627820Phase 2
7Transthyretin-Associated Amyloidoses Outcome Survey (THAOS)RecruitingNCT00628745
8Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.RecruitingNCT02260466

Search NIH Clinical Center for Wild Type Attr Amyloidosis

Genetic Tests for Wild Type Attr Amyloidosis

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Anatomical Context for Wild Type Attr Amyloidosis

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MalaCards organs/tissues related to Wild Type Attr Amyloidosis:

36
Heart, Bone

Publications for Wild Type Attr Amyloidosis

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Articles related to Wild Type Attr Amyloidosis:

idTitleAuthorsYear
1
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and SjAPgren's syndrome. (26339445)
2015

Variations for Wild Type Attr Amyloidosis

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Expression for genes affiliated with Wild Type Attr Amyloidosis

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Search GEO for disease gene expression data for Wild Type Attr Amyloidosis.

Pathways for genes affiliated with Wild Type Attr Amyloidosis

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GO Terms for genes affiliated with Wild Type Attr Amyloidosis

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Sources for Wild Type Attr Amyloidosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet