MCID: WLD005
MIFTS: 18

Wild Type Attr Amyloidosis malady

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Wild Type Attr Amyloidosis

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Sources:
52Orphanet, 66UMLS, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Wild Type Attr Amyloidosis:

Name: Wild Type Attr Amyloidosis 52
Senile Systemic Amyloidosis 52 66
Wild Type Attr-Related Amyloidosis 52
 
Attrwt-Related Amyloidosis 52
Attrwt Amyloidosis 52
Ssa 52

Characteristics:

Orphanet epidemiological data:

52
senile systemic amyloidosis:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Orphanet52 ORPHA330001
ICD10 via Orphanet29 E85.8

Summaries for Wild Type Attr Amyloidosis

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MalaCards based summary: Wild Type Attr Amyloidosis, also known as senile systemic amyloidosis, is related to lupus erythematosus and cutaneous lupus erythematosus, and has symptoms including Array, Array and Array. Affiliated tissues include heart and bone.

Related Diseases for Wild Type Attr Amyloidosis

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Graphical network of the top 20 diseases related to Wild Type Attr Amyloidosis:



Diseases related to wild type attr amyloidosis

Symptoms for Wild Type Attr Amyloidosis

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Symptoms:

 52 (show all 24)
  • renal insufficiency
  • proteinuria
  • nephrotic syndrome
  • nephropathy
  • hepatomegaly
  • congestive heart failure
  • hypertrophic cardiomyopathy
  • myocardial infarction
  • bradycardia
  • weight loss
  • chronic diarrhea
  • pleural effusion
  • intermittent diarrhea
  • autonomic dysregulation
  • gastrointestinal dysmotility
  • bowel incontinence
  • elevated alkaline phosphatase
  • abnormal ekg
  • arrhythmia
  • orthostatic hypotension due to autonomic dysfunction
  • autonomic bladder dysfunction
  • interstitial pulmonary disease
  • edema of the lower limbs
  • pulmonary edema

Drugs & Therapeutics for Wild Type Attr Amyloidosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyRecruitingNCT02791230Phase 3
2Safety and Efficacy of Tafamidis in Patients With Transthyretin CardiomyopathyActive, not recruitingNCT01994889Phase 3
3Safety And Efficacy Evaluation Of Fx-1006a In Patients With V122i Or Wild-Type Transthyretin (TTR) Amyloid CardiomyopathySuspendedNCT00935012Phase 3
4The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid CardiomyopathyCompletedNCT00694161Phase 2
5The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin AmyloidosisCompletedNCT00630864Phase 2
6The Effect of an Antisense Oligonucleotide to Lower Transthyretin (TTR) Levels on the Progression of -Wild-type TTR Involving the HeartWithdrawnNCT02627820Phase 2
7Transthyretin-Associated Amyloidoses Outcome Survey (THAOS)RecruitingNCT00628745
8Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.RecruitingNCT02260466

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Genetic Tests for Wild Type Attr Amyloidosis

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Anatomical Context for Wild Type Attr Amyloidosis

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MalaCards organs/tissues related to Wild Type Attr Amyloidosis:

34
Heart, Bone

Animal Models for Wild Type Attr Amyloidosis or affiliated genes

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Publications for Wild Type Attr Amyloidosis

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Articles related to Wild Type Attr Amyloidosis:

idTitleAuthorsYear
1
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and SjAPgren's syndrome. (26339445)
2015

Variations for Wild Type Attr Amyloidosis

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Expression for genes affiliated with Wild Type Attr Amyloidosis

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Search GEO for disease gene expression data for Wild Type Attr Amyloidosis.

Pathways for genes affiliated with Wild Type Attr Amyloidosis

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GO Terms for genes affiliated with Wild Type Attr Amyloidosis

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Sources for Wild Type Attr Amyloidosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet