SSA
MCID: WLD005
MIFTS: 22

Wild Type Attr Amyloidosis (SSA) malady

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Wild Type Attr Amyloidosis

Aliases & Descriptions for Wild Type Attr Amyloidosis:

Name: Wild Type Attr Amyloidosis 56
Senile Systemic Amyloidosis 56 69
Wild Type Attr-Related Amyloidosis 56
Attrwt-Related Amyloidosis 56
Attrwt Amyloidosis 56
Ssa 56

Characteristics:

Orphanet epidemiological data:

56
wild type attr amyloidosis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA330001
ICD10 via Orphanet 34 E85.8

Summaries for Wild Type Attr Amyloidosis

MalaCards based summary : Wild Type Attr Amyloidosis, also known as senile systemic amyloidosis, is related to amyloidosis, hereditary, transthyretin-related and lupus erythematosus, and has symptoms including renal insufficiency, proteinuria and nephrotic syndrome. Affiliated tissues include heart and bone.

Related Diseases for Wild Type Attr Amyloidosis

Graphical network of the top 20 diseases related to Wild Type Attr Amyloidosis:



Diseases related to Wild Type Attr Amyloidosis

Symptoms & Phenotypes for Wild Type Attr Amyloidosis

Human phenotypes related to Wild Type Attr Amyloidosis:

56 32 (show all 25)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 56 32 Occasional (29-5%) HP:0000083
2 proteinuria 56 32 Occasional (29-5%) HP:0000093
3 nephrotic syndrome 56 32 Occasional (29-5%) HP:0000100
4 nephropathy 56 32 Occasional (29-5%) HP:0000112
5 hepatomegaly 56 32 Frequent (79-30%) HP:0002240
6 congestive heart failure 56 32 Very frequent (99-80%) HP:0001635
7 hypertrophic cardiomyopathy 56 32 Very frequent (99-80%) HP:0001639
8 myocardial infarction 56 32 Very frequent (99-80%) HP:0001658
9 bradycardia 56 32 Occasional (29-5%) HP:0001662
10 weight loss 56 32 Occasional (29-5%) HP:0001824
11 chronic diarrhea 56 32 Frequent (79-30%) HP:0002028
12 pleural effusion 56 32 Very frequent (99-80%) HP:0002202
13 intermittent diarrhea 56 32 Frequent (79-30%) HP:0002254
14 autonomic dysregulation 56 32 Frequent (79-30%) HP:0002271
15 gastrointestinal dysmotility 56 32 Frequent (79-30%) HP:0002579
16 bowel incontinence 56 32 Frequent (79-30%) HP:0002607
17 elevated alkaline phosphatase 56 32 Frequent (79-30%) HP:0003155
18 abnormal ekg 56 32 Very frequent (99-80%) HP:0003115
19 orthostatic hypotension due to autonomic dysfunction 56 32 Frequent (79-30%) HP:0004926
20 autonomic bladder dysfunction 56 32 Frequent (79-30%) HP:0005341
21 edema of the lower limbs 56 32 Very frequent (99-80%) HP:0010741
22 pulmonary edema 56 32 Very frequent (99-80%) HP:0100598
23 arrhythmia 56 Frequent (79-30%)
24 interstitial pulmonary disease 56 Very frequent (99-80%)
25 interstitial pulmonary abnormality 32 HP:0006530

Drugs & Therapeutics for Wild Type Attr Amyloidosis

Interventional clinical trials:


id Name Status NCT ID Phase
1 Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy Recruiting NCT02791230 Phase 3
2 Safety And Efficacy Evaluation Of Fx-1006a In Patients With V122i Or Wild-Type Transthyretin (TTR) Amyloid Cardiomyopathy Active, not recruiting NCT00935012 Phase 3
3 Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy Active, not recruiting NCT01994889 Phase 3
4 The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid Cardiomyopathy Completed NCT00694161 Phase 2
5 The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin Amyloidosis Completed NCT00630864 Phase 2
6 The Effect of an Antisense Oligonucleotide to Lower Transthyretin (TTR) Levels on the Progression of -Wild-type TTR Involving the Heart Withdrawn NCT02627820 Phase 2
7 Transthyretin-Associated Amyloidoses Outcome Survey (THAOS) Recruiting NCT00628745
8 Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement. Recruiting NCT02260466

Search NIH Clinical Center for Wild Type Attr Amyloidosis

Genetic Tests for Wild Type Attr Amyloidosis

Anatomical Context for Wild Type Attr Amyloidosis

MalaCards organs/tissues related to Wild Type Attr Amyloidosis:

39
Heart, Bone

Publications for Wild Type Attr Amyloidosis

Articles related to Wild Type Attr Amyloidosis:

id Title Authors Year
1
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and SjAPgren's syndrome. ( 26339445 )
2015

Variations for Wild Type Attr Amyloidosis

Expression for Wild Type Attr Amyloidosis

Search GEO for disease gene expression data for Wild Type Attr Amyloidosis.

Pathways for Wild Type Attr Amyloidosis

GO Terms for Wild Type Attr Amyloidosis

Sources for Wild Type Attr Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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