MCID: WLD005
MIFTS: 21

Wild Type Attr Amyloidosis malady

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Wild Type Attr Amyloidosis

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Sources:
30ICD10 via Orphanet, 53Orphanet, 67UMLS
See all MalaCards sources

Aliases & Descriptions for Wild Type Attr Amyloidosis:

Name: Wild Type Attr Amyloidosis 53
Senile Systemic Amyloidosis 53 67
Wild Type Attr-Related Amyloidosis 53
 
Attrwt-Related Amyloidosis 53
Attrwt Amyloidosis 53
Ssa 53

Characteristics:

Orphanet epidemiological data:

53
senile systemic amyloidosis:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Orphanet53 ORPHA330001
ICD10 via Orphanet30 E85.8

Summaries for Wild Type Attr Amyloidosis

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MalaCards based summary: Wild Type Attr Amyloidosis, also known as senile systemic amyloidosis, is related to amyloidosis, hereditary, transthyretin-related and lupus erythematosus, and has symptoms including Array, Array and Array. Affiliated tissues include heart and bone.

Related Diseases for Wild Type Attr Amyloidosis

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Graphical network of the top 20 diseases related to Wild Type Attr Amyloidosis:



Diseases related to wild type attr amyloidosis

Symptoms for Wild Type Attr Amyloidosis

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Human phenotypes related to Wild Type Attr Amyloidosis:

 53 (show all 24)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency53 Occasional (29-5%)
2 proteinuria53 Occasional (29-5%)
3 nephrotic syndrome53 Occasional (29-5%)
4 nephropathy53 Occasional (29-5%)
5 hepatomegaly53 Frequent (79-30%)
6 congestive heart failure53 Very frequent (99-80%)
7 hypertrophic cardiomyopathy53 Very frequent (99-80%)
8 myocardial infarction53 Very frequent (99-80%)
9 bradycardia53 Occasional (29-5%)
10 weight loss53 Occasional (29-5%)
11 chronic diarrhea53 Frequent (79-30%)
12 pleural effusion53 Very frequent (99-80%)
13 intermittent diarrhea53 Frequent (79-30%)
14 autonomic dysregulation53 Frequent (79-30%)
15 gastrointestinal dysmotility53 Frequent (79-30%)
16 bowel incontinence53 Frequent (79-30%)
17 elevated alkaline phosphatase53 Frequent (79-30%)
18 abnormal ekg53 Very frequent (99-80%)
19 arrhythmia53 Frequent (79-30%)
20 orthostatic hypotension due to autonomic dysfunction53 Frequent (79-30%)
21 autonomic bladder dysfunction53 Frequent (79-30%)
22 interstitial pulmonary disease53 Very frequent (99-80%)
23 edema of the lower limbs53 Very frequent (99-80%)
24 pulmonary edema53 Very frequent (99-80%)

Drugs & Therapeutics for Wild Type Attr Amyloidosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyRecruitingNCT02791230Phase 3
2Safety And Efficacy Evaluation Of Fx-1006a In Patients With V122i Or Wild-Type Transthyretin (TTR) Amyloid CardiomyopathyActive, not recruitingNCT00935012Phase 3
3Safety and Efficacy of Tafamidis in Patients With Transthyretin CardiomyopathyActive, not recruitingNCT01994889Phase 3
4The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid CardiomyopathyCompletedNCT00694161Phase 2
5The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin AmyloidosisCompletedNCT00630864Phase 2
6The Effect of an Antisense Oligonucleotide to Lower Transthyretin (TTR) Levels on the Progression of -Wild-type TTR Involving the HeartWithdrawnNCT02627820Phase 2
7Transthyretin-Associated Amyloidoses Outcome Survey (THAOS)RecruitingNCT00628745
8Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.RecruitingNCT02260466

Search NIH Clinical Center for Wild Type Attr Amyloidosis

Genetic Tests for Wild Type Attr Amyloidosis

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Anatomical Context for Wild Type Attr Amyloidosis

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MalaCards organs/tissues related to Wild Type Attr Amyloidosis:

35
Heart, Bone

Animal Models for Wild Type Attr Amyloidosis or affiliated genes

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Publications for Wild Type Attr Amyloidosis

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Articles related to Wild Type Attr Amyloidosis:

idTitleAuthorsYear
1
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and SjAPgren's syndrome. (26339445)
2015

Variations for Wild Type Attr Amyloidosis

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Expression for genes affiliated with Wild Type Attr Amyloidosis

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Search GEO for disease gene expression data for Wild Type Attr Amyloidosis.

Pathways for genes affiliated with Wild Type Attr Amyloidosis

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GO Terms for genes affiliated with Wild Type Attr Amyloidosis

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Sources for Wild Type Attr Amyloidosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet