MCID: WLD005
MIFTS: 24

Wild Type Attr Amyloidosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Wild Type Attr Amyloidosis

MalaCards integrated aliases for Wild Type Attr Amyloidosis:

Name: Wild Type Attr Amyloidosis 55
Senile Systemic Amyloidosis 55 69
Wild Type Attr-Related Amyloidosis 55
Attrwt-Related Amyloidosis 55
Attrwt Amyloidosis 55
Ssa 55

Characteristics:

Orphanet epidemiological data:

55
wild type attr amyloidosis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:



Summaries for Wild Type Attr Amyloidosis

MalaCards based summary : Wild Type Attr Amyloidosis, also known as senile systemic amyloidosis, is related to sessile serrated polyposis cancer syndrome and amyloidosis, hereditary, transthyretin-related, and has symptoms including renal insufficiency, proteinuria and nephrotic syndrome. The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include heart and bone.

Related Diseases for Wild Type Attr Amyloidosis

Diseases related to Wild Type Attr Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 sessile serrated polyposis cancer syndrome 11.2
2 amyloidosis, hereditary, transthyretin-related 10.9
3 atrial standstill 1 10.5
4 heart block, congenital 10.4
5 lupus erythematosus 10.3
6 amyloidosis 10.2
7 cutaneous lupus erythematosus 10.1
8 connective tissue disease 10.1
9 subacute cutaneous lupus erythematosus 10.0
10 systemic lupus erythematosus 10.0
11 rheumatoid arthritis 10.0
12 arthritis 10.0
13 atrioventricular block 10.0
14 myelitis 9.9
15 undifferentiated connective tissue disease 9.9
16 endocardial fibroelastosis 9.9
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
18 transverse myelitis 9.9
19 ring chromosome y syndrome 9.8
20 discoid lupus erythematosus 9.8
21 adenoma 9.8
22 sjogren syndrome 9.8
23 lung disease 9.8
24 sialadenitis 9.8
25 chilblain lupus 1 9.8
26 acromegaly 9.8
27 antisynthetase syndrome 9.8
28 interstitial lung disease 9.8
29 end stage renal failure 9.7
30 hepatitis 9.7
31 purpura 9.7
32 fibrosis of extraocular muscles, congenital, 1 9.7
33 neuromyelitis optica 9.7
34 mixed connective tissue disease 9.7
35 systemic scleroderma 9.7
36 myopathy 9.7
37 thrombocytopenia 9.7
38 pneumonia 9.7
39 gitelman syndrome 9.7
40 first-degree atrioventricular block 9.7
41 diffuse infiltrative lymphocytosis syndrome 9.7
42 cardiac arrest 9.7
43 human immunodeficiency virus type 1 9.7
44 pleurisy 9.7
45 scarlet fever 9.7
46 neuropathy 9.7
47 squamous cell carcinoma 9.7
48 b-cell expansion with nfkb and t-cell anergy 9.7
49 status epilepticus 9.7
50 sensory peripheral neuropathy 9.7

Graphical network of the top 20 diseases related to Wild Type Attr Amyloidosis:



Diseases related to Wild Type Attr Amyloidosis

Symptoms & Phenotypes for Wild Type Attr Amyloidosis

Human phenotypes related to Wild Type Attr Amyloidosis:

55 31 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000083
2 proteinuria 55 31 occasional (7.5%) Occasional (29-5%) HP:0000093
3 nephrotic syndrome 55 31 occasional (7.5%) Occasional (29-5%) HP:0000100
4 nephropathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0000112
5 hepatomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0002240
6 congestive heart failure 55 31 hallmark (90%) Very frequent (99-80%) HP:0001635
7 hypertrophic cardiomyopathy 55 31 hallmark (90%) Very frequent (99-80%) HP:0001639
8 myocardial infarction 55 31 hallmark (90%) Very frequent (99-80%) HP:0001658
9 bradycardia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001662
10 weight loss 55 31 occasional (7.5%) Occasional (29-5%) HP:0001824
11 chronic diarrhea 55 31 frequent (33%) Frequent (79-30%) HP:0002028
12 pleural effusion 55 31 hallmark (90%) Very frequent (99-80%) HP:0002202
13 intermittent diarrhea 55 31 frequent (33%) Frequent (79-30%) HP:0002254
14 autonomic dysregulation 55 31 frequent (33%) Frequent (79-30%) HP:0002271
15 gastrointestinal dysmotility 55 31 frequent (33%) Frequent (79-30%) HP:0002579
16 bowel incontinence 55 31 frequent (33%) Frequent (79-30%) HP:0002607
17 elevated alkaline phosphatase 55 31 frequent (33%) Frequent (79-30%) HP:0003155
18 abnormal ekg 55 31 hallmark (90%) Very frequent (99-80%) HP:0003115
19 orthostatic hypotension due to autonomic dysfunction 55 31 frequent (33%) Frequent (79-30%) HP:0004926
20 autonomic bladder dysfunction 55 31 frequent (33%) Frequent (79-30%) HP:0005341
21 interstitial pulmonary abnormality 55 31 hallmark (90%) Very frequent (99-80%) HP:0006530
22 edema of the lower limbs 55 31 hallmark (90%) Very frequent (99-80%) HP:0010741
23 pulmonary edema 55 31 hallmark (90%) Very frequent (99-80%) HP:0100598
24 arrhythmia 55 Frequent (79-30%)

Drugs & Therapeutics for Wild Type Attr Amyloidosis

Drugs for Wild Type Attr Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
2 Anti-Bacterial Agents Phase 2
3 Anti-Infective Agents Phase 2
4 Antimalarials Phase 2
5 Antiprotozoal Agents Phase 2
6 Antiparasitic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Effect of Doxycycline in Patients With Amyloidosis Completed NCT01677286 Phase 2 Doxycycline 100 mg po bid x 12 months
2 The Effect of an Antisense Oligonucleotide to Lower Transthyretin (TTR) Levels on the Progression of -Wild-type TTR Involving the Heart Withdrawn NCT02627820 Phase 2 Isis 420915/GSK 299872
3 Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers Completed NCT01604122
4 Carpal Tunnel Syndrome and Amyloid Cardiomyopathy Active, not recruiting NCT02792790

Search NIH Clinical Center for Wild Type Attr Amyloidosis

Genetic Tests for Wild Type Attr Amyloidosis

Anatomical Context for Wild Type Attr Amyloidosis

MalaCards organs/tissues related to Wild Type Attr Amyloidosis:

38
Heart, Bone

Publications for Wild Type Attr Amyloidosis

Articles related to Wild Type Attr Amyloidosis:

# Title Authors Year
1
First nationwide survey on systemic wild-type ATTR amyloidosis in Japan. ( 29182024 )
2017
2
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and SjAPgren's syndrome. ( 26339445 )
2015

Variations for Wild Type Attr Amyloidosis

Expression for Wild Type Attr Amyloidosis

Search GEO for disease gene expression data for Wild Type Attr Amyloidosis.

Pathways for Wild Type Attr Amyloidosis

GO Terms for Wild Type Attr Amyloidosis

Sources for Wild Type Attr Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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