Wilms Tumor malady

MedlinePlus: Wilms' tumor is a rare type of kidney cancer that affects children. it causes a tumor on one or both kidneys. having certain genetic conditions or birth defects can increase the risk of developing wilms' tumor. children who are at risk should be screened for wilms' tumor every three months until they turn eight. possible signs of a kidney tumor include a lump in the abdomen and blood in the urine. the tumor is usually diagnosed and removed in surgery. other treatments include chemotherapy, radiation, biologic therapy or a combination. biologic therapy, or immunotherapy, boosts your body's own ability to fight cancer. most children with wilms' tumor can be cured. nih: national cancer institute²³

MalaCards: Wilms Tumor, also known as wilms' tumor, is related to nephroblastoma and wagr syndrome. An important gene associated with Wilms Tumor is WT1 (Wilms tumor 1), and among its related pathways are Epithelial Adherens Junctions and Pancreatic cancer. The compounds calcium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and kidney, and related mouse phenotypes are behavior/neurological and mortality/aging.

Wikipedia: Wilms\' tumor or nephroblastoma is cancer of the kidneys that typically occurs in children, rarely in...⁴⁴ more...

OMIM: 194070

GeneReviews summary for wilms-ov

wilms tumor 7 15 33 32 wilms' tumor 30 16 17 23 nephroblastoma 30 43

bilateral wilms tumor 30 wt1 30

Disease types for wilms tumor family:

wilms tumor 2	wilms tumor, type 1
wilms tumor, type 3	wilms tumor, type 4

Diseases related to wilms tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1025)

id	Related Disease	Score	Top Affiliating Genes
1	nephroblastoma	37.6	NCAM1, REN, VWF, VIM, VEGFC, PAX3
2	wagr syndrome	35.9	PAX6, BDNF, MPPED1, MPPED2, IGF2, WT1
3	aniridia	35.4	KIR2DS4, PAX3, PAX6, PAX2, BDNF, MPPED1
4	beckwith-wiedemann syndrome	34.8	NAP1L4, MYOD1, KCNQ1OT1, CDKN1C, GRB10, GPC3
5	denys-drash syndrome	34.8	PAX2, CD2AP, SRD5A1, SRY, NR5A1, PDGFA
6	myelodysplastic syndrome	33.5	VDR, BIRC5, MVP, CDKN1C, MLL, GZMB
7	acute lymphoblastic leukemia	33.5	MYCN, MYB, PAWR, PARK2, BCL2, BCL2L1
8	congenital mesoblastic nephroma	31.9	REN, VIM, MLL, IGF2, CTCF, SMARCB1
9	frasier syndrome	31.8	CD2AP, SRY, WT1, ACTN4, SOX9, NPHS2
10	metanephric adenoma	31.4	VIM, MUC1, AMACR, WT1, KRT7, DES
11	carcinoma	31.2	ZNF673, LRPAP1, NCAM1, REN, RET, VWF
12	down syndrome	31.2	MYC, MYCN, PAX6, CDKN1C, MLL, FLT3
13	desmoplastic small round cell tumor	31.1	MUC1, EWSR1, WT1, DES
14	dysgerminoma	31.0	BRCA1, BRCA2, INHA, ENO2, SRY, WT1
15	focal segmental glomerulosclerosis	30.8	PAX2, CD2AP, CDKN1C, PTPRO, WT1, ACTN4
16	adenomatoid tumor	30.8	VIM, MUC1, F8, CALB2, WT1, KRT7
17	sex reversal	30.7	PAX6, AR, AKR1C3, ESR1, SRY, CTNNB1
18	chronic myelomonocytic leukemia	30.6	BIRC5, CDK6, FLT3, EZH2, CREBBP, WT1
19	botryoid rhabdomyosarcoma	30.6	MYOG, MYOD1, PAX3, WT1, ACTC1, DES
20	mental retardation syndrome	30.6	VHL, PARK2, PAX6, BDNF, AVPR2, AR
21	ovarian cancer	30.5	BRCA1, BRCA2, CDK6, CDKN2A, CDK4, CCND2
22	sarcomatoid mesothelioma	30.5	VIM, MUC1, CALB2, PDPN, WT1, ACTC1
23	leukemia	30.4	ZNF673, LRPAP1, NCAM1, REN, KIR2DS4, VWF
24	cystic nephroma	30.4	VIM, MUC1, MME, DICER1, WT1, KRT7
25	hypospadias	30.4	SALL1, ATF3, AR, ESR1, CYR61, SRD5A1
26	renal cell carcinoma	30.3	RET, PCNA, SETD2, VIM, VHL, VEGFA
27	hemihypertrophy	30.3	CDKN1C, IGF2, WT1, TH, H19, AFP
28	disorders of sex development	30.3	AR, SRD5A1, SRY, NR0B1, NR5A1, WT1
29	46, xy disorders of sex development	30.3	AR, SRD5A1, SRY, NR0B1, NR5A1, WT1
30	gonadal dysgenesis	30.3	SRD5A1, SRY, NR0B1, NR5A1, RPL10, WT1
31	sertoli cell tumor	30.2	PCNA, VIM, MUC1, AR, INHA, ENO2
32	hodgkin's lymphoma	30.2	BRCA1, BRCA2, BCL2, BCL2L1, ITGA4, MLL
33	myeloproliferative disorder	30.2	VWF, MLL, IRF8, FLT3, FGF2, IL18R1
34	diffuse mesangial sclerosis	30.1	PAX2, WT1, NPHS1, NPHS2
35	rhabdoid tumors	30.0	VIM, MYOD1, MUC1, IGF1R, IGF2, PTPRC
36	burkitt's lymphoma	29.9	MYC, MYCN, MYB, BMP6, RASSF1, BIRC5
37	myeloid malignancy	29.9	PARK2, MLL, FLT3, IDH1, IDH2, TP53
38	clear cell adenocarcinoma	29.8	BRCA1, VEGFA, BIRC5, PAX8, PAX2, MUC16
39	adenosarcoma	29.8	MME, AR, MB, CALB2, ESR1, WT1
40	hirschsprung's disease	29.8	NCAM1, RET, PAX3, BCL2, CHGA, MME
41	breast cancer	29.8	BRCA1, BRCA2, VEGFA, VDR, PALB2, BCL2
42	ovarian clear cell adenocarcinoma	29.6	VEGFA, MUC16, CDH1, MET, ESR1, ERBB2
43	mesangial sclerosis	29.6	ZNF673, PAX2, PDGFA, WT1, TGFB1, NPHS1
44	sertoli-leydig cell tumor	29.5	VIM, MYOG, MUC1, MUC16, INHA, ENO2
45	papillary serous carcinoma of the peritoneum	29.5	BRCA1, MUC16, CALB2, WT1
46	malignant mesothelioma	29.4	NCAM1, PCNA, VIM, VEGFA, VEGFC, MYOG
47	cushing's syndrome	29.4	REN, RET, CHGA, AVPR2, INHA, MEN1
48	glioblastoma	29.3	SETD2, VHL, VEGFA, MYCN, BIRC5, BCL2L1
49	leydig cell tumor	29.3	VIM, MYOG, MUC1, MUC16, INHA, ENO2
50	hyperparathyroidism-jaw tumor syndrome	29.3	RET, CDC73, MEN1, CCND1, POLR2L

Clinical features from OMIM: 194070

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to wilms tumor:

²²

MGI Mouse Phenotypes related to wilms tumor:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	13.7	NCAM1, REN, VIM, BRCA2, LMO7, MYCN
2	mortality/aging	MP:0010768	12.5	LRPAP1, NCAM1, REN, RET, VWF, BTRC
3	craniofacial phenotype	MP:0005382	12.0	MYCN, PAX8, PAX3, PAX6, BDNF, SALL4
4	endocrine/exocrine gland phenotype	MP:0005379	11.5	LRPAP1, RET, BRCA1, BRCA2, PAX8, PAX3
5	normal phenotype	MP:0002873	11.4	LRPAP1, REN, RET, BRCA1, BRCA2, VHL
6	embryogenesis phenotype	MP:0005380	11.3	RET, BUB1B, RBBP7, SETD2, VIM, BRCA1
7	immune system phenotype	MP:0005387	11.3	REN, VWF, BUB1B, BTRC, VIM, BRCA1
8	respiratory system phenotype	MP:0005388	11.1	RET, BRCA1, LMO7, MYCN, MYOG, MYOD1
9	renal/urinary system phenotype	MP:0005367	11.0	LRPAP1, REN, RENBP, RET, BRCA1, VHL
10	hematopoietic system phenotype	MP:0005397	10.7	PCNA, BUB1B, BTRC, BRCA1, BRCA2, VHL
11	liver/biliary system phenotype	MP:0005370	10.6	VHL, VEGFA, MYCN, MYB, BID, KCNQ1OT1
12	growth/size phenotype	MP:0005378	10.6	REN, RET, BUB1B, SETD2, BRCA1, BRCA2
13	limbs/digits/tail phenotype	MP:0005371	10.4	RET, BRCA1, BRCA2, VHL, VEGFA, VDR
14	nervous system phenotype	MP:0003631	10.2	LRPAP1, REN, VWF, SERPINF1, BRCA1, LMO7
15	hearing/vestibular/ear phenotype	MP:0005377	9.9	VDR, MYC, PAX8, PAX3, PAX6, PAX2
16	other phenotype	MP:0005395	9.8	LRPAP1, AXIN1, CDKN2A, MME, AIRN, TP73
17	reproductive system phenotype	MP:0005389	9.7	LRPAP1, REN, RET, BUB1B, BTRC, SERPINF1
18	pigmentation phenotype	MP:0001186	9.3	SERPINF1, BRCA1, LMO7, MYC, PAX3, PAX6
19	integument phenotype	MP:0010771	9.2	BUB1B, BRCA1, BRCA2, VHL, LMO7, MYC
20	no phenotypic analysis	MP:0003012	9.1	RET, PCNA, VEGFA, MYC, MYOD1, PAX8
21	digestive/alimentary phenotype	MP:0005381	8.9	RET, VWF, SERPINF1, BRCA1, BRCA2, VHL
22	skeleton phenotype	MP:0005390	8.1	BUB1B, BRCA1, BRCA2, VHL, VEGFA, VDR
23	vision/eye phenotype	MP:0005391	8.1	NCAM1, BUB1B, SERPINF1, VIM, VEGFA, LMO7
24	cellular phenotype	MP:0005384	7.9	NCAM1, RET, VWF, PCNA, BUB1B, BTRC
25	cardiovascular system phenotype	MP:0005385	7.8	REN, RET, VWF, SETD2, SERPINF1, VIM
26	adipose tissue phenotype	MP:0005375	7.7	BUB1B, BRCA1, MYC, MYOG, MYOD1, BCL2
27	muscle phenotype	MP:0005369	7.3	REN, RET, BUB1B, VIM, BRCA1, VHL
28	homeostasis/metabolism phenotype	MP:0005376	7.0	LRPAP1, REN, RENBP, RET, VWF, BUB1B
29	tumorigenesis	MP:0002006	6.8	RET, BUB1B, BTRC, BRCA1, BRCA2, VHL

Articles related to wilms tumor:

(show top 50)    (show all 561)

id	Title	Authors	Year	Affiliating Genes
1	Clinical outcome and gene- and microRNA-expression pr ofiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs1 6754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer a nd Leukemia Group B study. (21659357)	Becker H.... Bloomfield C.D.	2011	WT1
2	The Wilms' tumor suppressor WT1 induces estrogen-inde pendent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF 7 cells. (20204298)	Wang L.... Wang Z.Y.	2010	EGFR, WT1
3	Mutations of the Wilms tumor 1 gene (WT1) in older pa tients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. (20442368)	Becker H.... Bloomfield C.D.	2010	WT1
4	Wilms' tumor protein Wt1 regulates the Interleukin-10 (IL-10) gene. (20974136)	Sciesielski L.K.... Persson A.B.	2010	WT1
5	Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine. (19351755)	Osada T.... Clay T.M.	2009	WT1
6	Wilms' tumor 1 gene expression in hepatocellular carcinoma promotes cell dedifferentiation and resistance to chemotherapy. (19190340)	Perugorria M.J.... Berasain C.	2009	CASP3, WT1
7	WNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries? (19530245)	Corbin M.... Jeanpierre C.	2009	CTNNB1
8	Wilms tumor arising in a child with X-linked nephroge nic diabetes insipidus. (19294427)	El-Kares R.... Goodyer P.	2009	AVPR2, AQP2
9	Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors : results of long-term surveillance of 71 patients from International Society of Pediatric Oncology Study 9/society for Pediatric Oncology. (18618575)	Royer-Pokora B.... von Harrach M.	2008	CTNNB1, WT1
10	Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. (17505014)	Rezvani K.... Barrett A.J.	2007	WT1
11	Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors. (18030365)	Chilukamarri L.... Malik K.	2007	GLIPR1
12	The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells. (17634147)	Han Y.... Minden M.D.	2007	WT1
13	WT1 (Wilms' tumor 1) peptide immunotherapy for renal cell carcinoma. (17579261)	Iiyama T.... Sugiyama H.	2007	WT1
14	Vascular biology and the sex of flies: regulation of vascular smooth muscle cell proliferation by wilms' tumor 1-associating protein. (17936204)	Small T.W.... Pickering J.G.	2007	WTAP
15	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. (17510365)	Major M.B.... Moon R.T.	2007	CTNNB1, AXIN1, BTRC
16	The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene. (16920711)	Kirschner K.M.... Scholz H.	2006	ITGA4, WT1
17	Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis. (16799645)	Timofeeva O.A.... Perantoni A.O.	2006	STAT1, HSPB1, CSNK2A1
18	Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. (16912181)	Rong Y.... Fu X.Y.	2006	WT1, ATF3, WTAP
19	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. (16614054)	Wagner N.... Schedl A.	2006	WT1, NES
20	HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells. (15674342)	Tuna M.... Tari A.M.	2005	ERBB2, WT1
21	Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development. (15737694)	Zirn B.... Gessler M.	2005	CTNNB1
22	Wilms Tumor Gene (WT1) and p53 expression in endometrial carcinomas: a study of 130 cases using a tissue microarray. (15297187)	Dupont J.... Soslow R.A.	2004	TP53, WT1
23	Differential expression of a novel ankyrin containing E3 ubiquitin- protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. (15254018)	Anglesio M.S.... Sorensen P.H.B.	2004	SMURF1, UBE2E3, HACE1
24	CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. (15579438)	Li C.M.... Tycko B.	2004	CTNNB1
25	Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma. (15245594)	Oji Y.... Sugiyama H.	2004	WT1
26	Transcriptional activity of testis-determining factor SRY is modulated by the Wilms' tumor 1 gene product, WT1. (12970737)	Matsuzawa-Watanabe Y.... Semba K.	2003	WT1, SRY
27	Responsiveness of chemotherapy based on the histologi cal type and Wilms' tumor suppressor gene mutation in bilateral Wilms' tumor. (12675764)	Shibata R.... Hata J.	2003	WT1
28	A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1. (11278547)	Wang W.... Haber D.A.	2001	CREBBP, WT1
29	Germline Wilms tumor suppressor gene (WT1) mutation leading to isolated genital malformation without Wilms tumor or nephropathy. (11241055)	KAPhler B.... GrA1ters A.	2001	WT1
30	Atypical variant of acquired von Willebrand syndrome in Wilms tumor: is hyaluronic acid secreted by nephroblastoma cells the cause? (11292185)	Michiels J.... Van der Planken M.	2001	VWF
31	Cancer immunotherapy targeting Wilms' tumor gene WT1 product. (10657636)	Oka Y.... Sugiyama H.	2000	WT1
32	Analysis of the p53 gene by PCR-SSCP in ten cases of Wilms' tumor. (10772697)	Defavery R.... Tone L.G.	2000	WT1
33	The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene. (10601322)	Oh S.... Kim T.K.	1999	TERT
34	Downregulation of Wilms' tumor gene (WT1) is not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562. (10378895)	Svedberg H.... Gullberg U.	1999	WT1
35	Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program. (9484784)	Svedberg H.... Gullberg U.	1998	WT1, PRDM2
36	Management of bilateral Wilms' tumors in the daughter of Jehovah's Witnesses. (9434021)	Ross J.H.... Alexander F.	1997	EPO
37	High molecular weight forms of IGF-II ('big-IGF-II') released by Wilms' tumor cells. (9368508)	Schmitt S.... Schoenle E.J.	1997	IGF2
38	Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function. (8687106)	Hewitt S.M.... Saunders G.F.	1996	ZNF673
39	Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor. (7534414)	Taniguchi T.... Reeve A.E.	1995	IGF2, H19
40	Expression of proliferating cell nuclear antigen in Wilms' tumors and other pediatric renal tumors: the correlation between histologic classification and proliferative activity. (7907158)	Nagoshi M.... Tsuneyoshi M.	1994	PCNA
41	Downregulation of Wilms' tumor gene (wt1) during myelomonocytic differentiation in HL60 cells. (8142654)	Sekiya M.... Yachi A.	1994	WT1, PRDM2
42	Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. (8390684)	Werner H.... Roberts C.T.	1993	IGF1R, IGF2
43	Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors. (8324644)	Bruening W.... Pelletier J.	1993	WT1
44	Regulation of kidney organogenesis: homeobox genes, growth factors, and Wilms tumor. (7922202)	Clapp W.L.... Abrahamson D.R.	1993	KIR2DS4
45	Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome. (7687865)	Gessler M.... Bruns G.	1993	WT1
46	Expression of the candidate Wilm's tumor gene, WT1, in human leukemia cells. (8321047)	Miyagi T.... Miyoshi I.	1993	WT1
47	Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes. (1335280)	Yeger H.... Williams B.R.	1992	WT1
48	Genomic changes in the WT-gene (WT1) in Wilms' tumors and their correlation with histology. (1314024)	Kikuchi H.... Hata J.	1992	WT1
49	Expression of the 11p13 Wilms' tumor gene, WT1, correlates with histologic category of Wilms' tumor. (1316081)	Gerald W.L.... Garvin A.J.	1992	WT1
50	High-resolution studies in patients with aniridia-Wilms tumor association, Wilms tumor or related congenital abnormalities. (6088386)	Nakagome Y.... Takada Y.	1984	WT1

Genes related to wilms tumor according to GeneCards:

(show top 50)    (show all 310)

id	Symbol	Description	Score	GeneCards Section Context
1	WT1	Wilms tumor 1	11.1	Summaries, Orthologs, Functions, Aliases & Descriptions (show all 6 sections) Publications, Transcripts
2	RPL10	ribosomal protein L10	11.1	Publications, Summaries, Aliases & Descriptions
3	WTAP	Wilms tumor 1 associated protein	11.1	Publications, Transcripts, Orthologs, Summaries (show all 5 sections) Aliases & Descriptions
4	WT1-AS	WT1 antisense RNA	11.1	Proteins, Aliases & Descriptions, Summaries, Publications
5	FAM123B	family with sequence similarity 123B	11.1	Publications, Aliases & Descriptions, UniProt Related, Summaries
6	POU6F2	POU class 6 homeobox 2	11.1	Aliases & Descriptions, Publications, Summaries
7	SLC22A18	solute carrier family 22, member 18	11.1	Summaries
8	WT3	Wilms tumor-3	11.1	Aliases & Descriptions
9	WT4	Wilms tumor-4	11.1	Aliases & Descriptions
10	NAP1L4	nucleosome assembly protein 1-like 4	11.1	Summaries
11	CTCF	CCCTC-binding factor (zinc finger protein)	11.1	Summaries, Publications
12	WT2	Wilms tumor 2	11.1	Disorders, Aliases & Descriptions
13	DEL11P13	Wilms tumor, aniridia, genitourinary anomalies and mental retardation syndrome	11.1	Aliases & Descriptions
14	KCNQ1DN	KCNQ1 downstream neighbor (non-protein coding)	11.0	Summaries, Publications, Expressions
15	HOXD10	homeobox D10	11.0	Summaries
16	CARS	cysteinyl-tRNA synthetase	11.0	Summaries
17	LOC646517	Wilms tumor 1 associated protein pseudogene	11.0	Aliases & Descriptions
18	WTIP	Wilms tumor 1 interacting protein	11.0	Orthologs, Aliases & Descriptions, Proteins, Publications (show all 5 sections) Transcripts
19	GPC3	glypican 3	11.0	Publications
20	AIRN	antisense of IGF2R non-protein coding RNA	11.0	Summaries
21	IGF2-AS	IGF2 antisense RNA	11.0	Summaries, UniProt Related, Publications
22	TSSC4	tumor suppressing subtransferable candidate 4	11.0	Summaries
23	PHLDA2	pleckstrin homology-like domain, family A, member 2	11.0	Summaries
24	STIM1	stromal interaction molecule 1	11.0	Summaries
25	TSSC1	tumor suppressing subtransferable candidate 1	11.0	Summaries
26	NUP98	nucleoporin 98kDa	11.0	Summaries
27	RRM1	ribonucleotide reductase M1	11.0	Summaries
28	TSPAN32	tetraspanin 32	11.0	Summaries
29	ZNF195	zinc finger protein 195	11.0	Summaries
30	WFDC1	WAP four-disulfide core domain 1	11.0	Summaries
31	LUZP2	leucine zipper protein 2	11.0	Summaries
32	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications, Functions
33	WTAPP1	Wilms tumor 1 associated protein pseudogene 1	11.0	Aliases & Descriptions
34	RSS	Russell Silver syndrome	11.0
35	KCNQ1OT1	KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)	11.0	Functions, Publications
36	NOV	nephroblastoma overexpressed	11.0	Publications, Expressions
37	POU4F2	POU class 4 homeobox 2	11.0	Publications
38	ZNF673	zinc finger family member 673	11.0	Publications
39	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Functions, Publications
40	PAX8	paired box 8	11.0	Expressions, Publications
41	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
42	PAX2	paired box 2	11.0	Publications
43	RENBP	renin binding protein	11.0
44	NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	11.0	Publications
45	PAX6	paired box 6	11.0	Publications
46	EGR2	early growth response 2	11.0	Publications
47	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
48	SYNPO	synaptopodin	11.0	Publications
49	PRDM2	PR domain containing 2, with ZNF domain	11.0	Publications
50	WISP2	WNT1 inducible signaling pathway protein 2	11.0

Pathways related to wilms tumor according to GeneDecks:

(show top 50)    (show all 161)

id	Pathway	Score	Top Affiliating Genes
1	Epithelial Adherens Junctions36	10.9	VEGFC, LMO7, BMP6, KEAP1, JUP, CDH1
2	Pancreatic cancer20	10.8	BRCA2, CDK6
3	CREB Pathway36	10.5	BMP6, BDNF, AREG, FGF7, IGF1R, IGF2R
4	JNK Pathway36	10.3	BMP6, BCL2, BAX, FLT1, FLT3, AREG
5	PPAR Pathway36	10.2	VEGFC, ITGA4, FLT1, AREG, FGF2, FGF7
6	Breast Cancer Regulation by Stathmin136	10.2	FGF2, FGF7, GRB10, IGF1R, CAMK2G, ERBB2
7	Ras Pathway36	10.1	VEGFC, ITGA4, FLT1, FLT3, AREG, FGF2
8	GSK3 Signaling36	10.0	BTRC, VEGFC, BMP6, BDNF, AXIN1, CDH3
9	14-3-3 Induced Intracellular Signaling36	10.0	VEGFC, BDNF, FLT1, FLT3, AREG, FGF2
10	Paxillin Interactions36	9.9	VEGFC, BDNF, ITGA4, FLT1, FLT3, AREG
11	Nuclear Receptor Activation by Vitamin-A36	9.8	VEGFC, BMP6, BDNF, FLT1, AREG, FGF2
12	Nanog in Mammalian ESC Pluripotency36	9.8	VEGFC, BMP6, BDNF, AXIN1, FLT1, FLT3
13	Rho Family GTPases36	9.8	VIM, VEGFC, BMP6, BDNF, BCL2, BAX
14	Akt Signaling36	9.8	VEGFC, FLT3, FGF7, MET, IL18R1, CCND2
15	ILK Signaling36	9.7	VIM, VEGFC, BDNF, CDH3, CDH13, CDH16
16	Activation of PKA through GPCR36	9.7	VEGFC, BMP6, BDNF, FLT1, FLT3, AREG
17	Apoptotic Pathways in Synovial Fibroblasts36	9.6	VEGFC, BMP6, BDNF, FLT1, AREG, FGF2
18	Telomerase Components in Cell Signaling36	9.6	VEGFC, MYC, BMP6, BDNF, FLT1, AREG
19	TGF-Beta Pathway36	9.6	VEGFC, BMP6, BDNF, BCL2, BAX, CDH1
20	ERK5 Signaling36	9.5	VEGFC, MYC, BMP6, BDNF, FLT1, AREG
21	Rac1 Pathway36	9.5	BMP6, BDNF, ITGA4, AREG, FGF2, FGF7
22	Activation of cAMP-Dependent PKA36	9.5	VEGFC, BDNF, FLT1, FLT3, AREG, FGF7
23	NFAT in Immune Response36	9.5	VEGFC, BMP6, BDNF, FLT1, FLT3, AREG
24	NF-KappaB (p50-p65) Pathway36	9.5	BTRC, VEGFC, BMP6, BDNF, UBC, FLT1
25	mTOR Pathway36	9.2	VEGFC, BMP6, BDNF, AREG, FGF2, FGF7
26	GPCR Pathway36	9.2	VEGFC, BMP6, BDNF, FLT1, FLT3, AREG
27	DHA Signaling36	9.2	SERPINF1, VEGFC, BMP6, BID, BDNF, BCL2
28	Intracellular Calcium Signaling36	9.2	VEGFC, BMP6, BDNF, FLT1, FLT3, AREG
29	eNOS Signaling36	9.2	BMP6, BDNF, FLT3, AREG, FGF7, MET
30	p53 Mediated Apoptosis36	9.0	VEGFC, BMP6, BID, BDNF, BCL2, BAX
31	p70S6K Signaling36	9.0	VEGFC, BMP6, BDNF, FLT1, AREG, FGF2
32	Renin-Angiotensin Pathway36	8.9	REN, VEGFC, BMP6, BDNF, FLT1, AREG
33	ERK Signaling36	8.8	VEGFC, MYC, BMP6, PAX6, ITGA4, FLT1
34	Focal adhesion20	8.8	VWF, VEGFC, BCL2, ITGA4, FLT1, MET
35	JAK-STAT Pathway36	8.7	BRCA1, VEGFC, MYC, BMP6, BDNF, BCL2
36	Estrogen Pathway36	8.5	BRCA1, VEGFC, BMP6, BDNF, BCL2, FLT1
37	Bladder cancer20	8.5	VEGFA, VEGFC, MYC, RASSF1, CDKN2A, CDK4
38	Endothelin-1 Signaling Pathway36	8.5	MYC, BMP6, FLT1, FLT3, IGF1R, CASP3
39	Tec Kinases Signaling36	8.5	VEGFC, BMP6, BDNF, BCL2, BAX, ITGA4
40	Melanoma20	8.5	CDK6, CDKN2A, CDK4, CDH1, FGF2, FGF7
41	PAK Pathway36	8.5	VEGFC, BMP6, BDNF, BCL2, BAX, FLT1
42	MAPK Signaling36	8.4	VEGFC, MYC, BMP6, BDNF, BCL2, ATF3
43	Mitochondrial Apoptosis36	8.3	VEGFC, BMP6, BID, BDNF, BCL2, BCL2L1
44	Cellular Apoptosis Pathway36	8.1	VEGFC, BMP6, BID, PAWR, BDNF, BCL2
45	Antioxidant Action of Vitamin-C36	8.1	VEGFC, BMP6, BDNF, BCL2, BAX, FLT1
46	Glioma20	8.0	CDK6, CDKN2A, CDK4, CCND1, IGF1R, IGF1
47	p38 Signaling36	7.9	VEGFC, BMP6, BDNF, BCL2, BAX, CEBPA
48	Pancreatic Adenocarcinoma36	7.6	BRCA2, VEGFC, BMP6, BIRC5, BDNF, BCL2
49	Molecular Mechanisms of Cancer36	7.4	BRCA1, VEGFC, MYC, BMP6, BID, BDNF
50	Pathways in cancer20	6.8	RET, BRCA2, VEGFA, VEGFC, MYC, RASSF1

Compounds related to wilms tumor according to GeneDecks:

(show top 50)    (show all 440)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	15.2	LRPAP1, REN, VWF, SET, SERPINF1, BRCA1
2	nitric oxide32 9 18 9	14.5	NCAM1, REN, SERPINF1, VHL, VEGFC, MYCN
3	glucose32	11.4	SETD2, SERPINF1, VHL, VEGFC, MYOG, MYOD1
4	leucine32	11.2	RENBP, RET, VIM, MYC, MYCN, MYB
5	methionine32	11.1	RET, VWF, SERPINF1, VIM, MYB, RASSF1
6	gnrh32	10.9	NCAM1, VIM, MME, AR, INHA, IGFBP3
7	polysaccharide32	10.6	NCAM1, BMP6, AREG, AR, FGF2, IL18R1
8	proline32	10.4	SETD2, VIM, BRCA1, BRCA2, VHL, PARK2
9	atp32	10.4	NCAM1, RENBP, RET, SETD2, BRCA1, MYOD1
10	sp 60012532 42	11.3	BID, FGF7, CASP3, TP53, CTGF
11	bleomycin32 9 9	12.2	BRCA1, BRCA2, MVP, FGF2, FGF7, IGF1
12	5-aza-2deoxycytidine32	10.2	PCNA, VIM, BRCA1, VHL, MYC, MYOD1
13	pge232	10.2	REN, SETD2, CDH1, MME, AR, FGF2
14	ribonucleic acid32	10.2	RET, VEGFC, MYC, MYOG, BMP6, PAX8
15	cholesterol32 9 18 9	13.1	LRPAP1, REN, VWF, BIRC5, BDNF, CHGA
16	1,25 dihydroxy vitamin d332	10.0	VDR, MYC, BMP6, CDK6, CDK4, FGF7
17	azathioprine32 34 9 9	13.0	PCNA, VIM, MYOD1, RASSF1, MTHFR, CDKN2A
18	dihydrotestosterone32 9 18 9	12.9	SETD2, VIM, VDR, BMP6, CDK6, CDK4
19	sodium nitroprusside32	9.8	REN, VWF, PCNA, MYB, BMP6, MME
20	glycogen32 18	10.7	BTRC, SETD2, VIM, VHL, MYC, PARK2
21	vitamin d32	9.5	VIM, VDR, BMP6, CHGA, MTHFR, CD36
22	estradiol32 9 18 9	12.5	REN, PCNA, VIM, BRCA1, BRCA2, VEGFC
23	iron32 18	10.5	SETD2, VIM, VHL, MYCN, MYB, PARK2
24	cysteine32	9.4	RENBP, KIR2DS4, PCNA, SERPINF1, BRCA1, VDR
25	glutamine32	9.4	NCAM1, VWF, PCNA, VIM, BRCA1, BRCA2
26	oxygen32 18	10.4	SETD2, SERPINF1, BRCA1, MYOG, MYB, MYOD1
27	mitoxantrone32 9 9	11.3	BIRC5, BCL2, MVP, FLT3, IGF1R, IFNA2
28	progestin32	9.2	VIM, VEGFA, CDK6, CDK4, CDH1, AR
29	matrigel32	9.2	NCAM1, VWF, SERPINF1, VIM, BRCA2, VEGFA
30	okadaic acid32 42	10.2	VIM, MYC, MYB, BMP6, PARK2, BCL2
31	prostacyclin32	9.2	REN, VWF, VEGFA, BMP6, MME, FLT1
32	aspartate32	9.2	RET, PCNA, VIM, VDR, BMP6, BDNF
33	hydroxyurea32 9 9	11.1	PCNA, BRCA1, BRCA2, MYC, MYCN, CDKN2A
34	superoxide32 18	9.9	SETD2, BIRC5, PARK2, BAK1, CDK4, MME
35	alanine32	8.9	NCAM1, RET, VWF, PCNA, BRCA1, VDR
36	agar32	8.8	RET, VIM, BRCA1, MYCN, RASSF1, BIRC5
37	adpribose32	8.5	PCNA, BRCA1, BRCA2, BID, BIRC5, BCL2L1
38	thymidine32 18	9.4	PCNA, BRCA1, BRCA2, VEGFC, VDR, MYC
39	folate32	8.3	VWF, VIM, BRCA1, BRCA2, VHL, VDR
40	calcitriol32 42 9 18 9	12.3	REN, VDR, MYC, BMP6, BAK1, CD36
41	carboplatin32 34 9 9	11.3	BRCA1, VEGFA, BID, BCL2, CHGA, MUC16
42	paraffin32	8.2	NCAM1, RET, VWF, PCNA, VIM, BRCA1
43	indomethacin32 9 9	10.0	REN, PCNA, VIM, MYC, BMP6, BIRC5
44	flavopiridol32 9 9	9.9	VEGFA, BID, BIRC5, BCL2, BCL2L1, BAK1
45	n-(4-hydroxyphenyl)retinamide32	7.6	VIM, MYC, BMP6, BCL2, BCL2L1, BAX
46	arsenite32 18	8.1	PCNA, SETD2, VEGFA, VDR, MYC, BIRC5
47	tamoxifen32 34 9 9	9.4	PCNA, VIM, BRCA1, BRCA2, VEGFA, VDR
48	adriamycin32	6.4	VIM, BRCA1, BRCA2, VDR, MYC, MYCN
49	gemcitabine32 34 9 9	8.8	PCNA, BRCA1, VEGFA, MYC, BID, BIRC5
50	pd 98,05932	5.8	RET, SETD2, VEGFC, MYC, MYOG, BMP6

Cellular components related to wilms tumor according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.8	RET, TNF, EREG, IGF2R, GPC3, MET
2	nucleolus	GO:005730	10.1	ATF3, CEP57, UBE2E3, BBS9, KEAP1, PAX6
3	cell surface	GO:009986	10.1	TNF, HSPB1, IGF2R, FLT3, CDH1, CD36
4	platelet alpha granule lumen	GO:031093	10.0	HGF, TGFB1, THBS1, ACTN4, ACTN1, EGF
5	endoplasmic reticulum	GO:005783	9.6	PRKCA, STIM1, RPL10, CRAT, CRABP2, PTN
6	perinuclear region of cytoplasm	GO:048471	9.4	NDRG2, EGFR, ABL1, ACTN4, TGFA, PRKACA
7	nucleoplasm	GO:005654	9.2	GATA1, SMARCB1, NR5A1, NR1H2, NR0B1, CTCF
8	protein complex	GO:043234	9.0	TP53, PTGS2, ACTN4, TOP2A, SYP, PRKCA
9	nucleus	GO:005634	9.0	STAT3, WTAP, WT1, NFE2L2, NOTCH1, CREBBP
10	extracellular region	GO:005576	8.9	VEGFC, LRPAP1, KLK3, PDGFA, NOV, NOTCH1
11	cytosol	GO:005829	8.3	ENO2, GRB10, FBXW11, FAM123B, CCND2, CCND1
12	plasma membrane	GO:005886	8.3	KRT1, KRAS, ZYX, EDNRA, EGF, EGFR
13	cytoplasm	GO:005737	8.2	AR, CDKN2A, FGF2, FLT1, GZMB, MME
14	extracellular space	GO:005615	8.1	WFDC1, THBS1, HBEGF, EGFR, EGF, EDN3

Biological processes related to wilms tumor according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	kidney development	GO:001822	11.3	REN, SERPINF1, SIX1, MME, ODC1, PAX8
2	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.1	IFI16, NOTCH1, WT1, EGR1, TGFB1, TGIF1
3	male gonad development	GO:008584	11.0	REN, BCL2, BCL2L1, AR, INHA, MET
4	lung development	GO:030324	11.0	NKX2-1, PDPN, CEBPA, MYCN, FGF2, CRH
5	negative regulation of epithelial cell proliferation	GO:050680	10.9	SOX9, PAX6, TGFB1, CDKN1C, CDK6, CDC73
6	branching involved in ureteric bud morphogenesis	GO:001658	10.9	GDNF, SIX1, SOX9, WT1, FGF2, BCL2
7	positive regulation of cell migration	GO:030335	10.8	CYR61, PDPN, HBEGF, ABCC1, EGFR, PTK2
8	cellular response to growth factor stimulus	GO:071363	10.8	HTRA2, CAT, MET, SPARC, MYOG, SRD5A1
9	positive regulation of cell division	GO:051781	10.8	CAT, EREG, PTN, PDGFA, THBS4, TGFA
10	negative regulation of transcription, DNA-dependent	GO:045892	10.7	CTCF, WT1, TGFB1, SOX9, ZNF224, NOTCH1
11	positive regulation of MAPK cascade	GO:043410	10.7	CD36, IGF1, FLT1, FLT3, AR, IGFBP3
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.6	IFI16, IGF1, FGF2, AR, BMP6, MYOD1
13	organ morphogenesis	GO:009887	10.6	PDGFA, TH, FGF2, FLI1, EREG, PALB2
14	positive regulation of gene expression	GO:010628	10.6	NTRK2, VEGFA, VDR, PAX6, CITED1, AVPR2
15	positive regulation of transcription, DNA-dependent	GO:045893	10.3	SIX1, NKX2-1, STAT3, E2F3, SALL1, EPO
16	transcription initiation from RNA polymerase II promoter	GO:006367	10.3	MEN1, NR0B1, VDR, MYC, UBC, E2F3
17	cell cycle arrest	GO:007050	10.3	HTRA2, MEN1, INHA, TGFB1, CDKN2A, CDK6
18	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.3	PDGFA, NTRK2, PTK2, CAT, F2, IGF1
19	response to gamma radiation	GO:010332	10.3	BAX, PTPRC, TP53, MEN1, BCL2, MYC
20	ossification	GO:001503	10.2	MYOG, BCL2, SPARC, SOX9, CTGF, SP1
21	negative regulation of cell growth	GO:030308	10.2	DNAJB2, TGFB1, PPP2CA, PPP2R1A, WFDC1, WT1
22	regulation of cell cycle	GO:051726	10.1	PTGS2, BTRC, PTPRC, DICER1, BAK1, BAX
23	negative regulation of neuron apoptotic process	GO:043524	10.0	CITED1, BCL2, BAX, PARK2, BDNF, BCL2L1
24	positive regulation of protein kinase B signaling cascade	GO:051897	9.9	PDGFA, PTK2, TNF, AKR1C3, IGF2, TGFB1
25	positive regulation of epithelial cell proliferation	GO:050679	9.9	IGF1, PAX2, SOX9, TGFB1, TGFA, VEGFC
26	platelet degranulation	GO:002576	9.9	VEGFC, SPARC, IGF1, EGF, ACTN1, ACTN4
27	response to hypoxia	GO:001666	9.9	BCL2, CAT, TNF, CREBBP, WTIP, EDNRA
28	positive regulation of fibroblast proliferation	GO:048146	9.8	PDGFA, MYC, CDK4, IGF1, EREG, TGIF1
29	release of cytochrome c from mitochondria	GO:001836	9.8	CASP3, TP73, TP53, MYC, BAX, BCL2L1
30	positive regulation of mitosis	GO:045840	9.8	EGF, MET, EDN3, IGF2, IGF1, TGFA
31	positive regulation of MAP kinase activity	GO:043406	9.7	EGFR, FLT3, TGFB1, FLT1, EGF, EDN3
32	positive regulation of apoptotic process	GO:043065	9.7	BID, TP53, IGFBP3, MEN1, MMP9, MSX1
33	angiogenesis	GO:001525	9.6	PRKCA, EREG, TGFA, HIF1A, HSPB1, EPHB2
34	induction of apoptosis	GO:006917	9.5	STAT1, TGFB1, THBS1, PAWR, CDKN2A, INHA
35	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	PTGS2, FLT1, IGF1, EREG, TNF, HBEGF
36	induction of apoptosis by intracellular signals	GO:008629	9.4	GZMB, PRKCA, MYC, BID, CASP3, BCL2L1
37	positive regulation of cell proliferation	GO:008284	9.3	VEGFA, VEGFC, MYC, BIRC5, BCL2L1, CIAO1
38	response to wounding	GO:009611	9.3	TGFB1, PDGFA, PAX6, CASP3, F2, MET
39	anti-apoptosis	GO:006916	9.3	EPO, HSPB1, HSPA1B, TNF, THBS1, GDNF
40	activation of MAPK activity	GO:000187	9.3	UBC, S1PR2, HGF, SOD1, THBS1, PTPRC
41	negative regulation of apoptotic process	GO:043066	9.2	DICER1, PTK2, SOX9, TNF, VEGFA, CYR61
42	response to estradiol stimulus	GO:032355	9.2	BID, MMP9, ENO2, ESR1, CCND2, BRCA2
43	apoptotic process	GO:006915	9.2	CITED1, UBC, BAK1, BAX, AXIN1, CDH1
44	signal transduction	GO:007165	9.1	CDK4, CSNK2A1, CXXC5, RET, SPARC, CRABP2
45	response to ethanol	GO:045471	9.0	SPARC, BCL2, BAK1, MMP9, CCND2, CCND1
46	negative regulation of cell proliferation	GO:008285	8.9	PAWR, BAK1, CEBPA, MSX1, CDK6, CDC73
47	blood coagulation	GO:007596	8.9	ACTN4, ACTN1, ABL1, EGF, KRAS, THBS1
48	platelet activation	GO:030168	8.8	VWF, ACTN4, THBS1, TGFB1, PRKCA, SOD1
49	positive regulation of protein phosphorylation	GO:001934	8.7	SOX9, TNF, VEGFA, PRKCA, AXIN1, CCND2
50	response to drug	GO:042493	8.4	VEGFC, REN, MYC, BDNF, MET, MMP9

Molecular functions related to wilms tumor according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding transcription factor activity	GO:003700	11.6	FOXD1, TGIF1, STAT3, STAT1, PRDM2, SOX9
2	chromatin binding	GO:003682	11.5	AR, DNMT3A, TGIF1, TOP2A, SOX9, CITED1
3	insulin-like growth factor binding	GO:005520	11.2	WISP3, CTGF, WISP2, WISP1, NOV, IGFBP3
4	sequence-specific DNA binding	GO:043565	11.1	MEN1, SIX1, HIF1A, GATA1, VDR, NR0B1
5	DNA binding	GO:003677	11.1	TOP2A, ABL1, EGR1, NFE2L2, NR5A1, NR1H2
6	transcription regulatory region DNA binding	GO:044212	11.1	TP73, TNF, SP1, CTCF, CTNNB1, WT1
7	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	10.9	HNF4A, NKX2-1, SOX9, HIF1A, NR5A1, SRY
8	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	10.8	SP1, TP63, HNF4A, GATA1, POU4F2, TP53
9	double-stranded DNA binding	GO:003690	10.7	WT1, STAT1, NR5A1, NR0B1, CTNNB1, SP1
10	heparin binding	GO:008201	10.5	THBS4, LRPAP1, VEGFA, FGF2, FGF7, PTPRC
11	fibronectin binding	GO:001968	10.5	THBS4, THBS1, IGFBP3, MMP9, ITGA4, CTGF
12	ubiquitin protein ligase binding	GO:031625	10.4	PRKACA, SLC22A18, TP53, AXIN1, HIF1A, EGR2
13	beta-catenin binding	GO:008013	10.4	CSNK2A1, AR, ESR1, MET, CDH1, SALL1
14	transcription factor binding	GO:008134	10.3	BCL2, TP73, HIF1A, CREBBP, NR0B1, UBE2I
15	protein homodimerization activity	GO:042803	10.2	NPM1, PTPRO, TERT, TRIM37, SP1, NTRK2
16	receptor binding	GO:005102	9.9	REN, NPPA, EPHB2, GDNF, EDN3, CRH
17	protease binding	GO:002020	9.7	BRCA2, BCL2, UBC, HSPA1B, TP53, CST3
18	growth factor activity	GO:008083	9.6	GDNF, HGF, WISP3, CSF3, CSF1, CTGF
19	protein heterodimerization activity	GO:046982	9.6	NPM1, HGF, TP53, ENO2, ERBB2, PPP2R1A
20	identical protein binding	GO:042802	9.5	SLC2A1, ESR1, ERBB2, TP53, TP63, TP73
21	protein kinase binding	GO:019901	9.2	NPM1, VIM, PARK2, TP73, TP53, PTK2
22	enzyme binding	GO:019899	8.0	CCND1, NOTCH1, VHL, BRCA1, PAWR, UBE2I
23	protein binding	GO:005515	7.8	MEN1, IGF1, IFI16, IFNA2, F8, HTRA2