WT1
MCID: WLM002
MIFTS: 50

Wilms Tumor (WT1) malady

Nephrological, Cancer categories

Summaries for Wilms Tumor

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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MedlinePlus:34 Wilms' tumor is a rare type of kidney cancer. it causes a tumor on one or both kidneys. it usually affects children, but can happen in adults. having certain genetic conditions or birth defects can increase the risk of getting it. children that are at risk should be screened for wilms' tumor every three months until they turn eight. symptoms include a lump in the abdomen, blood in the urine, and a fever for no reason. tests that examine the kidney and blood are used to find the tumor. doctors usually diagnose and remove the tumor in surgery. other treatments include chemotherapy and radiation and biologic therapies. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Wilms Tumor, also known as wilms' tumor, is related to beckwith-wiedemann syndrome and williams-beuren syndrome. An important gene associated with Wilms Tumor is BRCA2 (breast cancer 2, early onset). Affiliated tissues include skin, ovary and liver.

Wikipedia:64 Wilms\' tumor, Wilms tumor (/vɪlmz/), or nephroblastoma is cancer of the kidneys that typically occurs... more...

Description from OMIM:47 194070

GeneReviews summary for wilms-ov

Aliases & Classifications for Wilms Tumor

Sources:
19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 47OMIM, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological


Aliases & Descriptions:

wilms tumor 19 47 45
wilms' tumor 43 20 22 34
bilateral wilms tumor 43 61
nephroblastoma 43 61
williams-beuren syndrome 19
wt1 43


Related Diseases for Wilms Tumor

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the wilms tumor, type 1 family:

wilms tumor familial wilms tumor 2
familial wilms tumor wilms tumor 2
wilms tumor, type 3 wilms tumor, type 4

Diseases related to Wilms Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1beckwith-wiedemann syndrome30.9WT1, CTCF, PHLDA2, TSPAN32, NAP1L4, SLC22A18
2williams-beuren syndrome11.4
3williams syndrome11.4
4aniridia10.9
5renal wilms' tumor10.9
6acute leukemia10.8
7wagr syndrome10.7
8n syndrome10.7
9denys-drash syndrome10.7
10acute myeloid leukemia10.6
11hemihypertrophy10.6
12adult syndrome10.6
13t-cell leukemia10.6
14familial wilms tumor10.6
15supravalvular aortic stenosis10.6
16horseshoe kidney10.5
17williams-beuren region duplication syndrome10.5
18acute t cell leukemia10.5
19embryoma10.5
20clear cell sarcoma10.5
21kidney clear cell sarcoma10.5
22meacham syndrome10.5
23rhabdoid tumor10.4
24wilms tumor, somatic10.4
25hereditary wilms' tumor10.4
26renal hamartomas nephroblastomatosis and fetal gigantism10.4
27wilms tumor 210.4
28mesoblastic nephroma10.4
29autistic disorder10.4
30young syndrome10.4
31bod syndrome10.4
32chromosome 7q deletion10.4
33mass syndrome10.4
34metanephric adenoma10.3
35adenocarcinoma10.3
36adenoma10.3
37micro syndrome10.3
38acute myeloid leukemia, adult10.3
39wilms tumor and radial bilateral aplasia10.3
40gigantism10.3
41epithelial predominant wilms' tumor10.3
42fanconi's anemia10.3
43mulibrey nanism10.3
44focal glomerulosclerosis10.3
45char syndrome10.3
46desmoplastic small round cell tumor10.3
47teratoma10.3
48renal dysplasia10.3
49nephrotic syndrome, type 410.3
50neurofibromatosis10.2

Graphical network of the top 20 diseases related to Wilms Tumor:



Diseases related to wilms tumor

Clinical Features for Wilms Tumor

Sources:
47OMIM
See all sources

Clinical features from OMIM:

194070

Drugs & Therapeutics for Wilms Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Wilms Tumor

Drug clinical trials:

Search ClinicalTrials for Wilms Tumor

Search NIH Clinical Center for Wilms Tumor

Search CenterWatch for Wilms Tumor

Genetic Tests for Wilms Tumor

Sources:
20GeneTests, 22GTR
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Genetic tests related to Wilms Tumor:

id Genetic test Affiliating Genes
1 Wilms Tumor20 WT1
2 Wilms' Tumor22

Anatomical Context for Wilms Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Wilms Tumor:

33
Skin, Ovary, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Uterus, Bone marrow, Whole blood, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Thyroid, Adrenal gland, Breast, Prostate, Testis, Cervix, Myeloid, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Testis germ

Animal Models for Wilms Tumor or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Wilms Tumor

Sources:
51PubMed
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Articles related to Wilms Tumor:

(show top 50)    (show all 1209)
idTitleAuthorsYear
1
Association of TP53 polymorphisms on the risk of Wilms tumor. (24038938)
2014
2
Correlation of tumor-associated macrophages and clinicopathological factors in Wilms tumor. (23514200)
2013
3
Immunohistochemical expression of Wilms' tumor protein (WT1) in developing human epithelial and mesenchymal tissues. (22673530)
2013
4
Single institution experience with Tru-Cut renal mass biopsy for diagnosing Wilms tumor. (23504682)
2013
5
Oncologic outcomes of partial versus radical nephrectomy for unilateral Wilms tumor. (21744482)
2012
6
SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor. (22703800)
2012
7
Adult wilms tumor with intracaval and intracardiac extension: report of a case and review of literature. (21479132)
2011
8
Wilms tumor 1 expression in vascular neoplasms and vascular malformations. (21697701)
2011
9
Late toxicity in Wilms tumor patients treated with radiotherapy at 15 years of median follow-up. (20736847)
2010
10
Wilms tumor, AML, and medulloblastoma in a child with cancer prone syndrome of total premature chromatid separation and Fanconi anemia. (19856400)
2010
11
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. (20972333)
2010
12
Dual use of a single Wilms' tumor 1 immunohistochemistry in evaluation of ovarian tumors: a preliminary study of 20 cases. (20842229)
2010
13
Synchronous occurrence of metastatic Wilms tumor and ganglioneuroma. (20658632)
2010
14
Characterizing clinicopathological findings of transarterial chemoembolization for Wilms tumor. (20096886)
2010
15
Expression of HIF-1, galectin-3, cox-2 and Wilms tumor-1 protein in multiple schwannomas of the conus medullaris. (18998056)
2009
16
Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival. (19605357)
2009
17
Renal cell carcinoma as second malignancy in patient with previous Wilms tumor. (19523667)
2009
18
New insights into DNA-binding behavior of Wilms tumor protein (WT1)--a dual study. (19853363)
2009
19
Wilms' tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation. (17599043)
2008
20
Molecular profiling of CD34+ cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms' tumor gene 1 (WT1). (16990584)
2007
21
Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. (16518847)
2006
22
Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. (15628914)
2005
23
Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy. (15957141)
2005
24
Prevalence of and risk factors for hydrocele in survivors of Wilms tumor. (14966834)
2004
25
Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumors. (15504250)
2004
26
Suppression of prostate tumor cell growth in vivo by WT1, the Wilms' tumor suppressor gene. (14767530)
2004
27
Overexpression of human Dickkopf-1, an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms' tumors. (12649343)
2003
28
Characteristics and outcomes of children with the Wilms tumor-Aniridia syndrome: a report from the National Wilms Tumor Study Group. (14673045)
2003
29
Activation of vitamin D receptor by the Wilms' tumor gene product mediates apoptosis of renal cells. (11373341)
2001
30
Germline Wilms tumor suppressor gene (WT1) mutation leading to isolated genital malformation without Wilms tumor or nephropathy. (11241055)
2001
31
Transcriptional regulation of the androgen signaling pathway by the Wilms' tumor suppressor gene WT1. (11299720)
2001
32
Penetrance of mutations in the familial Wilms tumor gene FWT1. (10772684)
2000
33
Characteristics and outcome of children with Beckwith-Wiedemann syndrome and Wilms' tumor: a report from the National Wilms Tumor Study Group. (10811666)
2000
34
Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor. (10506193)
1999
35
Pathological angiogenesis in a murine model of human Wilms' tumor. (10359162)
1999
36
Polymerase chain reaction-based risk assessment for Wilms tumor in sporadic aniridia. (9625553)
1998
37
Loss of imprinting of the IGF2 gene in a Wilms' tumor in an adult. (9392625)
1997
38
Management of bilateral Wilms' tumors in the daughter of Jehovah's Witnesses. (9434021)
1997
39
Fine needle aspiration cytology of clear cell sarcoma of the kidney and its distinction from Wilms' tumor. (9167736)
1997
40
The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1). (8760285)
1996
41
Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms tumor gene) expression levels. (8822948)
1996
42
Expression of WT1 protein in fetal kidneys and Wilms tumors. (7967503)
1994
43
Unique dermal and subcutaneous botryoid rhabdomyosarcoma associated with mature renal tissue: is this an extrarenal Wilms' tumor? (7971581)
1994
44
Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching. (8391213)
1993
45
MR demonstration of reversible cerebral lesions in a child with hypertensive encephalopathy caused by Wilms' tumor. (1314476)
1992
46
Congenital hemihypertrophy and Wilms' tumor. (1333447)
1992
47
Transcriptional repression mediated by the WT1 Wilms tumor gene product. (1654597)
1991
48
Early detection of Wilms' tumor in a child with hemihypertrophy and ovarian cysts. (6283465)
1982
49
Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia. (6272980)
1981
50
The association of aniridia, Wilms's tumor, and genital abnormalities. (4285715)
1965

Genetic Variations for Wilms Tumor

Expression for genes affiliated with Wilms Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wilms Tumor

Search GEO for disease gene expression data for Wilms Tumor.

Pathways for genes affiliated with Wilms Tumor

Compounds for genes affiliated with Wilms Tumor

GO Terms for genes affiliated with Wilms Tumor

Products for genes affiliated with Wilms Tumor

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Sources for Wilms Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet