WT1
MCID: WLM002
MIFTS: 41

Wilms Tumor (WT1) malady

Nephrological diseases, Cancer diseases categories

Summaries for Wilms Tumor

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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MedlinePlus:33 Wilms' tumor is a rare type of kidney cancer. it causes a tumor on one or both kidneys. it usually affects children, but can happen in adults. having certain genetic conditions or birth defects can increase the risk of getting it. children that are at risk should be screened for wilms' tumor every three months until they turn eight. symptoms include a lump in the abdomen, blood in the urine, and a fever for no reason. tests that examine the kidney and blood are used to find the tumor. doctors usually diagnose and remove the tumor in surgery. other treatments include chemotherapy and radiation and biologic therapies. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Wilms Tumor, also known as wilms' tumor, is related to nephroblastoma and beckwith-wiedemann syndrome. An important gene associated with Wilms Tumor is BRCA2 (breast cancer 2, early onset). Affiliated tissues include kidney and testes.

Wikipedia:63 Wilms\' (/vɪlmz/) tumor, Wilms tumor, or nephroblastoma is cancer of the kidneys that typically occurs... more...

Description from OMIM:46 194070

GeneReviews summary for wilms-ov

Aliases & Classifications for Wilms Tumor

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Sources:
42NIH Rare Diseases, 60UMLS, 19GeneReviews, 46OMIM, 44Novoseek, 20GeneTests, 22GTR, 33MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

wilms tumor 19 46 44
wilms' tumor 42 20 22 33
bilateral wilms tumor 42 60
nephroblastoma 42 60
wt1 42


Related Diseases for Wilms Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Wilms Tumor, Type 1 family:

wilms tumor Familial Wilms Tumor 2
Familial Wilms Tumor Wilms Tumor 2
Wilms Tumor, Type 3 Wilms Tumor, Type 4

Diseases related to Wilms Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 342)
idRelated DiseaseScoreTop Affiliating Genes
1nephroblastoma31.2POU6F2, WTAP, WT1
2beckwith-wiedemann syndrome30.9TSPAN32, TSSC4, SLC22A18, NAP1L4, PHLDA2, CTCF
3sarcoma30.8WT1, BRCA2
4breast cancer30.8TSPAN32, SLC22A18, RRM1, CTCF, BRCA2
5rhabdomyosarcoma30.4WT1, SLC22A18
6leukemia10.9
7aniridia10.9
8renal wilms' tumor10.9
9acute leukemia10.8
10myeloid leukemia10.7
11wagr syndrome10.7
12denys-drash syndrome10.6
13acute myeloid leukemia10.6
14embryoma10.5
15lymphoblastic leukemia10.5
16clear cell sarcoma10.4
17kidney clear cell sarcoma10.4
18hypertension10.4
19kidney sarcoma10.4
20pseudohermaphroditism10.4
21renal cell carcinoma10.4
22meacham syndrome10.4
23hereditary wilms' tumor10.4
24neuroblastoma10.4
25renal hamartomas nephroblastomatosis and fetal gigantism10.4
26prostatitis10.3
27metanephric adenoma10.3
28adenocarcinoma10.3
29adenoma10.3
30gonadal dysgenesis10.3
31hepatitis10.3
32malignant mesothelioma10.3
33medulloblastoma10.3
34t-cell leukemia10.3
35wilms tumor and radial bilateral aplasia10.3
36epithelial predominant wilms' tumor10.3
37mulibrey nanism10.3
38acute t cell leukemia10.3
39focal glomerulosclerosis10.3
40hepatitis a10.3
41childhood leukemia10.3
42nephrotic syndrome10.3
43peritonitis10.3
44nephrotic syndrome, type 410.2
45cystic kidney10.2
46neurofibromatosis10.2
47stromal predominant kidney wilms' tumor10.2
48mixed cell type kidney wilms' tumor10.2
49blastema predominant kidney wilms' tumor10.2
50bloom syndrome10.2

Graphical network of the top 20 diseases related to Wilms Tumor:



Diseases related to wilms tumor

Clinical Features for Wilms Tumor

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Sources:
46OMIM
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Clinical features from OMIM:

194070

Drugs & Therapeutics for Wilms Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Wilms Tumor

Drug clinical trials:

Search ClinicalTrials for Wilms Tumor

Search NIH Clinical Center for Wilms Tumor

Search CenterWatch for Wilms Tumor

Genetic Tests for Wilms Tumor

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20GeneTests, 22GTR
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Genetic tests related to Wilms Tumor:

id Genetic test Affiliating Genes
1 Wilms Tumor20 WT1
2 Wilms' Tumor22

Anatomical Context for Wilms Tumor

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32MalaCards
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MalaCards organs/tissues related to Wilms Tumor:

32
Kidney, Testes

Animal Models for Wilms Tumor or affiliated genes

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Publications for Wilms Tumor

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Genetic Variations for Wilms Tumor

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Wilms Tumor:

62
id Symbol AA change Variation ID SNP ID
1WT1p.Pro181SerVAR_007739rs2234584
2WT1p.Ser223AsnVAR_007740
3WT1p.Gly253AlaVAR_007741
4WT1p.Arg366CysVAR_007745
5WT1p.Arg366HisVAR_007746
6WT1p.His373GlnVAR_007747
7WT1p.Arg394TrpVAR_007750
8WT1p.Cys355GlyVAR_043799
9WT1p.Arg394LeuVAR_043807

Expression for genes affiliated with Wilms Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wilms Tumor

Search GEO for disease gene expression data for Wilms Tumor.

Pathways for genes affiliated with Wilms Tumor

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Compounds for genes affiliated with Wilms Tumor

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GO Terms for genes affiliated with Wilms Tumor

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Products for genes affiliated with Wilms Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Wilms Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet