Wilms Tumor malady

Genetic diseases, Rare diseases, Nephrological diseases, Cancer diseases categories

Aliases & Classifications for Wilms Tumor

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45OMIM, 30LifeMap Discovery®, 10diseasecard, 19GeneReviews, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 9Disease Ontology, 11DISEASES, 60UMLS, 22GTR, 20GeneTests, 32MedlinePlus, 38NCIt, 33MeSH, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Wilms Tumor, Aliases & Descriptions:

Name: Wilms Tumor 45 30 10 19 41 43 47
Nephroblastoma 9 41 11 47 60
Wilms' Tumor 41 20 22 32
Renal Embryonic Tumor 41 47
Bilateral Wilms Tumor 41 60
Wilms Tumor-1 10 22
Childhood Renal Wilms' Cancer 9
Adult Renal Wilms' Tumor 9
Adult Renal Wilms Tumor 60
Adult Nephroblastoma 9
Wilms Tumor, Somatic 45
Wilms Tumor, Type 1 45
Renal Wilms Tumor 9
Wt1 41


Characteristics (Orphanet epidemiological data):

wilms tumor:
Inheritance: Autosomal dominant,Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (United Kingdom),1-5/10000 (Europe); Age of onset: Childhood; Age of death: any age

External Ids:

OMIM45 194070
Disease Ontology9 DOID:2154
MeSH33 D009396
Orphanet47 654
MESH via Orphanet34 D009396
ICD10 via Orphanet26 C64
UMLS via Orphanet61 C0027708

Summaries for Wilms Tumor

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MedlinePlus:32 Wilms' tumor is a rare type of kidney cancer. it causes a tumor on one or both kidneys. it usually affects children, but can happen in adults. having certain genetic conditions or birth defects can increase the risk of getting it. children that are at risk should be screened for wilms' tumor every three months until they turn eight. symptoms include a lump in the abdomen, blood in the urine, and a fever for no reason. tests that examine the kidney and blood are used to find the tumor. doctors usually diagnose and remove the tumor in surgery. other treatments include chemotherapy and radiation and biologic therapies. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards based summary: Wilms Tumor, also known as nephroblastoma, is related to wagr syndrome and wilms tumor 2, and has symptoms including abdominal pain, renal neoplasm and hematuria. An important gene associated with Wilms Tumor is WT1 (Wilms tumor 1), and among its related pathways is Integrated Pancreatic Cancer Pathway. The compounds nap-2 and thymidine have been mentioned in the context of this disorder. Affiliated tissues include children, kidney and myeloid, and related mouse phenotypes are cellular and embryogenesis.

Disease Ontology:9 A kidney cancer that affects the kidneys and typically located in children.

Wikipedia:63 Wilms\' (/v?lmz/) tumor, Wilms tumor, or nephroblastoma is cancer of the kidneys that typically occurs... more...

Description from OMIM:45 194070

GeneReviews summary for wilms-ov

Related Diseases for Wilms Tumor

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Diseases in the Wilms Tumor family:

Wilms Tumor 2 Hereditary Wilms' Tumor
Familial Wilms Tumor 2 Familial Wilms Tumor

Diseases related to Wilms Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 294)
idRelated DiseaseScoreTop Affiliating Genes
1wagr syndrome31.8WT1
2wilms tumor 231.2H19
3perlman syndrome31.1DIS3L2, GPC3
4beckwith-wiedemann syndrome31.1PHLDA2, TSSC4, WT1, SLC22A18, H19, GPC3
5rhabdomyosarcoma31.0SLC22A18, WT1, H19
6gigantism31.0H19, GPC3
7hemi 3 syndrome30.9H19, WT1
8breast cancer30.9BRCA2, H19, GPC3, SLC22A18, RRM1
9hepatoblastoma30.8GPC3, H19, SLC22A18
10lung cancer30.8RRM1
11teratoma30.7GPC3, H19
12silver-russell syndrome30.6H19
13embryonal rhabdomyosarcoma30.5H19, WT1
14dysgerminoma30.4BRCA2, WT1
17myeloid leukemia10.8
18denys-drash syndrome10.7
20horseshoe kidney10.6
21acute leukemia10.5
23lymphoblastic leukemia10.5
24meacham syndrome10.5
25clear cell sarcoma10.5
27familial wilms tumor10.5
28renal cell carcinoma10.4
30wilms tumor susceptibility-510.4
31renal wilms' tumor10.4
33rhabdoid tumor10.4
34cytogenetically normal acute myeloid leukemia10.4
35insulin-like growth factor i10.4
36hereditary wilms' tumor10.4
37wilms tumor and radial bilateral aplasia10.4
38mesoblastic nephroma10.4
41nephrotic syndrome, idiopathic, steroid-resistant10.4
43myelodysplastic syndrome10.4
44mulibrey nanism10.4
46blastema predominant kidney wilms' tumor10.4
47epithelial predominant wilms' tumor10.4
48mixed cell type kidney wilms' tumor10.4
49stromal predominant kidney wilms' tumor10.4
50metanephric adenoma10.4

Graphical network of the top 20 diseases related to Wilms Tumor:

Diseases related to wilms tumor

Symptoms for Wilms Tumor

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Symptoms by clinical synopsis from OMIM:


Clinical features from OMIM:



 47 (show all 11)
  • acute abdominal pain/colic
  • neoplasms/tumors
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • aniridia/iris hypoplasia
  • chronic arterial hypertension
  • lymphadenopathy/polyadenopathies
  • hematuria/microhematuria
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling

HPO human phenotypes related to Wilms Tumor:

(show all 14)
id Description Frequency HPO Source Accession
1 abdominal pain hallmark (90%) HP:0002027
2 renal neoplasm hallmark (90%) HP:0009726
3 hematuria occasional (7.5%) HP:0000790
4 hypertension occasional (7.5%) HP:0000822
5 weight loss occasional (7.5%) HP:0001824
6 lymphadenopathy occasional (7.5%) HP:0002716
7 neoplasm of the liver occasional (7.5%) HP:0002896
8 abnormality of temperature regulation occasional (7.5%) HP:0004370
9 aplasia/hypoplasia of the iris occasional (7.5%) HP:0008053
10 neoplasm of the lung occasional (7.5%) HP:0100526
11 autosomal dominant inheritance HP:0000006
12 heterogeneous HP:0001425
13 somatic mutation HP:0001428
14 nephroblastoma (wilms tumor) HP:0002667

Drugs & Therapeutics for Wilms Tumor

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Drug clinical trials:

Search ClinicalTrials for Wilms Tumor

Search NIH Clinical Center for Wilms Tumor

Genetic Tests for Wilms Tumor

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Genetic tests related to Wilms Tumor:

id Genetic test Affiliating Genes
1 Wilms Tumor20 WT1
2 Wilms' Tumor22
3 Wilms Tumor, Type 122

Anatomical Context for Wilms Tumor

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MalaCards organs/tissues related to Wilms Tumor:

Kidney, Myeloid, Testes, T cells, Breast, Lung, Liver, Endothelial, Bone, Colon, Prostate, Testis, Eye, Cortex, Ovary, Pituitary, Bone marrow, Lymph node, Thyroid, Brain, Heart, Smooth muscle, Uterus, B cells, Retina, Pancreas, Adrenal gland, Skin, Cervix, Skeletal muscle

FMA organs/tissues related to Wilms Tumor:


Animal Models for Wilms Tumor or affiliated genes

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MGI Mouse Phenotypes related to Wilms Tumor:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6GPC3, AMER1, BRCA2, H19, PHLDA2, WT1
2MP:00053809.3WT1, GPC3, AMER1, BRCA2, H19, PHLDA2

Publications for Wilms Tumor

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Articles related to Wilms Tumor:

(show top 50)    (show all 1211)
The association of level of reduction of Wilms' tumor gene 1 mRNA transcript in bone marrow and outcome in acute myeloid leukemia patients. (25890432)
Invited reply on PBC-13-0662.R2: Biomarkers and wilms tumor. (24376227)
Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. (24100041)
Treatment of Wilms tumor in low-income countries: challenges and potential solutions. (23902235)
Perlman Syndrome: Overgrowth, Wilms Tumor Predisposition and DIS3L2. (23576526)
Study of histopathological features and proliferation markers in cases of Wilms' tumor. (22988352)
Multicenter study identified molecular blood-born protein signatures for Wilms Tumor. (21913182)
Surgical management of Wilms tumor with intravascular extension: a single-institution experience. (22304010)
Identification of potential serum biomarkers for Wilms tumor after excluding confounding effects of common systemic inflammatory factors. (22160518)
Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression. (22475129)
Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. (22842668)
Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. (21734473)
Teratoid Wilms' tumor: case report of a rare variant that can mimic aggressive biology during chemotherapy. (22152898)
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi. (20122399)
Successful treatment of late, recurrent wilms tumor with high-dose chemotherapy and autologous stem cell rescue in third complete response. (20628317)
Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. (20442368)
Value and difficulties of a common European strategy for recurrent Wilms' tumor. (19496704)
Expression of multidrug resistance-related protein (MRP-1), lung resistance-related protein (LRP) and topoisomerase-II (TOPO-II) in Wilms' tumor: immunohistochemical study using TMA methodology. (18795074)
Molecular cytogenetic anomalies and phenotype alterations in a newly established cell line from Wilms tumor with diffuse anaplasia. (18558285)
Regulation of CRABP-II expression by MycN in Wilms tumor. (18955045)
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. (17204608)
AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1. (16380455)
Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. (16518847)
Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies. (15538407)
Wilms' tumor 1 (WT1) gene in hematopoiesis: a surrogate marker of cell proliferation as a possible mechanism of action? (16040384)
Usefulness of quantitative assessment of Wilms tumor suppressor gene expression in chronic myeloid leukemia patients undergoing imatinib therapy. (12783374)
del11(p11-13) with overexpression of Wilms' tumor gene during leukemic transformation of myelodysplastic syndrome. (12424545)
A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1. (11278547)
Coexpression of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in Wilms' tumor. (11101729)
WT1 splicing alterations in Wilms' tumors. (11051244)
Wilms' tumors and malformation complexes]. (10921316)
Immunohistochemical detection of the Wilms' tumor gene (WT1) in epithelial ovarian tumors. (10782413)
The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains. (10390530)
Midkine stimulates Wilms' tumor cell proliferation via its signaling receptor. (9193798)
Transactivation of an intronic hematopoietic-specific enhancer of the human Wilms' tumor 1 gene by GATA-1 and c-Myb. (9361007)
Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia. (8943879)
Differential function of Wilms' tumor gene WT1 splice isoforms in transcriptional regulation. (8621487)
Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor. (8621549)
The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1). (8760285)
Constitutional and somatic mutations in the WT1 gene in Wilms' tumor patients. (7591260)
Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. (7596170)
P-glycoprotein status of favorable-histology Wilms' tumor predicts treatment outcome. (7965510)
Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor. (8381965)
Deletion of WT1 and WIT1 genes and loss of heterozygosity on chromosome 11p in Wilms tumors in Japan. (8393432)
Serum biological markers and paraneoplastic syndromes in Wilms tumor. (8383282)
WT1: a novel tumor suppressor gene inactivated in Wilms' tumor. (1313285)
Identification of the cellular protein encoded by the human Wilms' tumor (WT1) gene. (1334252)
Transcriptional repression mediated by the WT1 Wilms tumor gene product. (1654597)
Aniridia, cataracts, and Wilms' tumor in monozygous twins. (209691)
Embryoma of kidney (Wilms' tumor) in children. (18137842)

Variations for Wilms Tumor

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UniProtKB/Swiss-Prot genetic disease variations for Wilms Tumor:

id Symbol AA change Variation ID SNP ID

Clinvar genetic disease variations for Wilms Tumor:

6 (show all 12)
id Gene Variation Type Significance SNP ID Assembly Location
1GPC3NM_004484.3(GPC3): c.361C> T (p.His121Tyr)single nucleotide variantPathogenicrs122453119GRCh37Chr X, 132888180: 132888180
2GPC3NM_004484.3(GPC3): c.1705G> A (p.Ala569Thr)single nucleotide variantPathogenicrs122453120GRCh37Chr X, 132670190: 132670190
3H19H19, 1.43-KB TRIPLICATIONundetermined variantPathogenic
4POU6F2NM_007252.3(POU6F2): c.573G> T (p.Gln191His)single nucleotide variantrisk factorrs121918261GRCh37Chr 7, 39379302: 39379302
5POU6F2POU6F2, C-G, EXON 1C, 5-PRIME UTRsingle nucleotide variantPathogenic
6WT1NM_001198551.1(WT1): c.242_258del17 (p.Asn81Ilefs)deletionPathogenicGRCh38Chr 11, 32417633: 32417649
7WT1NM_001198551.1(WT1): c.443delG (p.Gly148Valfs)deletionPathogenicGRCh38Chr 11, 32399967: 32399967
8WT1NM_000378.4(WT1): c.1321C> T (p.Arg441Ter)single nucleotide variantPathogenicrs121907909GRCh37Chr 11, 32413578: 32413578
9WT1NM_000378.4(WT1): c.1237C> T (p.Arg413Ter)single nucleotide variantPathogenicrs121907906GRCh37Chr 11, 32414263: 32414263
10WT1NM_000378.4(WT1): c.531C> A (p.Tyr177Ter)single nucleotide variantPathogenicrs121907911GRCh37Chr 11, 32456361: 32456361
11BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenic, risk factorrs80359604GRCh37Chr 13, 32903606: 32903607
12BRCA2NM_000059.3(BRCA2): c.5645C> G (p.Ser1882Ter)single nucleotide variantPathogenic, risk factorrs80358785GRCh37Chr 13, 32914137: 32914137

Expression for genes affiliated with Wilms Tumor

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LifeMap Discovery
Genes differentially expressed in tissues of Wilms Tumor patients vs. healthy controls: 30 (show all 334)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CDH16cadherin 16, KSP-cadherinKidney-11.180.000
2SLC12A1solute carrier family 12 (sodium/potassium/chloride transporter), member 1Kidney-10.670.000
3SOX11SRY (sex determining region Y)-box 11Kidney+9.640.000
4LYPD1LY6/PLAUR domain containing 1Kidney+9.370.000
5ACSM2Aacyl-CoA synthetase medium-chain family member 2AKidney-9.290.009
6FXYD4FXYD domain containing ion transport regulator 4Kidney-9.210.000
7CALB1calbindin 1, 28kDaKidney-9.110.000
8TOP2Atopoisomerase (DNA) II alpha 170kDaKidney+9.070.000
9SCNN1Asodium channel, non-voltage-gated 1 alpha subunitKidney-8.780.000
10KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1Kidney-8.780.000
11EYA1eyes absent homolog 1 (Drosophila)Kidney+8.660.000
12EGFepidermal growth factorKidney-8.650.000
13NAT8N-acetyltransferase 8 (GCN5-related, putative)Kidney-8.650.001
14COL2A1collagen, type II, alpha 1Kidney+8.570.000
15SMIM24small integral membrane protein 24Kidney-8.350.000
16MIOXmyo-inositol oxygenaseKidney-8.150.000
17TMEM52Btransmembrane protein 52BKidney-8.080.000
18PDZK1IP1PDZK1 interacting protein 1Kidney-8.070.000
19BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1Kidney-8.040.000
20ALDOBaldolase B, fructose-bisphosphateKidney-8.040.022
21MALmal, T-cell differentiation proteinKidney-7.980.000
22ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4Kidney-7.930.000
25CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1Kidney+7.810.000
26SIX1SIX homeobox 1Kidney+7.760.000
27BHMTbetaine--homocysteine S-methyltransferaseKidney-7.740.003
28NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin)Kidney-7.680.000
29DEFB1defensin, beta 1Kidney-7.640.000
30KLHDC7Akelch domain containing 7AKidney-7.600.000
31OGDHLoxoglutarate dehydrogenase-likeKidney-7.520.000
32CLDN8claudin 8Kidney-7.440.000
33CLCNKBchloride channel, voltage-sensitive KbKidney-7.430.000
34HPD4-hydroxyphenylpyruvate dioxygenaseKidney-7.390.010
35TACSTD2tumor-associated calcium signal transducer 2Kidney-7.380.000
36FXYD2FXYD domain containing ion transport regulator 2Kidney-7.320.000
37TMEM45Btransmembrane protein 45BKidney-7.310.000
38SCNN1Gsodium channel, non-voltage-gated 1, gamma subunitKidney-7.300.000
39MFSD4major facilitator superfamily domain containing 4Kidney-7.270.000
40TMEM213transmembrane protein 213Kidney-7.260.000
41MUC15mucin 15, cell surface associatedKidney-7.250.000
42TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)Kidney-7.240.000
43PDZK1PDZ domain containing 1Kidney-7.200.004
44HMGA2high mobility group AT-hook 2Kidney+7.200.000
45SLC13A1solute carrier family 13 (sodium/sulfate symporter), member 1Kidney-7.190.000
46PAHphenylalanine hydroxylaseKidney-7.160.018
47FGF1fibroblast growth factor 1 (acidic)Kidney-7.160.000
48DNASE1deoxyribonuclease IKidney-7.130.000
49SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Kidney-7.130.000
50G6PCglucose-6-phosphatase, catalytic subunitKidney-7.100.017
51EGOTeosinophil granule ontogeny transcript (non-protein coding)Kidney-7.090.000
52CXCL14chemokine (C-X-C motif) ligand 14Kidney-7.070.008
54DDCdopa decarboxylase (aromatic L-amino acid decarboxylase)Kidney-7.020.001
55CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 11Kidney-6.980.007
57C12orf39chromosome 12 open reading frame 39Kidney-6.960.000
58TTKTTK protein kinaseKidney+6.950.000
59CAPN3calpain 3, (p94)Kidney-6.950.000
60SLC3A1solute carrier family 3 (amino acid transporter heavy chain), member 1Kidney-6.930.000
61VASH2vasohibin 2Kidney+6.880.001
62SLC22A2solute carrier family 22 (organic cation transporter), member 2Kidney-6.880.000
63BRIP1BRCA1 interacting protein C-terminal helicase 1Kidney+6.870.000
64SLC22A6solute carrier family 22 (organic anion transporter), member 6Kidney-6.870.000
65AGXT2alanine--glyoxylate aminotransferase 2Kidney-6.870.001
66KCNJ10potassium inwardly-rectifying channel, subfamily J, member 10Kidney-6.860.000
67TSPAN1tetraspanin 1Kidney-6.860.000
68KNG1kininogen 1Kidney-6.850.012
69CDHR5cadherin-related family member 5Kidney-6.830.000
70IRX2iroquois homeobox 2Kidney-6.810.000
71SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2Kidney-6.780.000
72MEOX1mesenchyme homeobox 1Kidney+6.780.000
73TNFRSF11Btumor necrosis factor receptor superfamily, member 11bKidney-6.780.000
74MUC20mucin 20, cell surface associatedKidney-6.720.001
75CPXM1carboxypeptidase X (M14 family), member 1Kidney+6.720.000
76TMEM37transmembrane protein 37Kidney-6.710.001
77GBA3glucosidase, beta, acid 3Kidney-6.710.003
78SLC7A13solute carrier family 7 (anionic amino acid transporter), member 13Kidney-6.670.000
79KIF20Akinesin family member 20AKidney+6.640.000
80TPX2TPX2, microtubule-associatedKidney+6.620.000
81ESRRBestrogen-related receptor betaKidney-6.600.000
82UPP2uridine phosphorylase 2Kidney-6.580.000
83C14orf105chromosome 14 open reading frame 105Kidney-6.570.000
84ZNF44zinc finger protein 44Kidney-6.570.000
85OSR1odd-skipped related transciption factor 1Kidney+6.560.000
86ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Kidney+6.540.000
87CCNB2cyclin B2Kidney+6.510.000
88FCAMRFc receptor, IgA, IgM, high affinityKidney-6.500.001
89SLC17A3solute carrier family 17 (organic anion transporter), member 3Kidney-6.490.000
90CDC25Ccell division cycle 25CKidney+6.480.000
91CENPAcentromere protein AKidney+6.470.000
92LOC100506098uncharacterized LOC100506098Kidney-6.470.000
93UHRF1ubiquitin-like with PHD and ring finger domains 1Kidney+6.450.000
94HEPACAM2HEPACAM family member 2Kidney-6.440.001
95SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11Kidney-6.430.000
96SCG5secretogranin V (7B2 protein)Kidney+6.410.000
97SCNN1Bsodium channel, non-voltage-gated 1, beta subunitKidney-6.410.000
98COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)Kidney-6.410.000
99UGT2B28UDP glucuronosyltransferase 2 family, polypeptide B28Kidney-6.400.016
100TNNT1troponin T type 1 (skeletal, slow)Kidney+6.390.000
101ACMSDaminocarboxymuconate semialdehyde decarboxylaseKidney-6.390.003
102C9orf66chromosome 9 open reading frame 66Kidney-6.390.000
103LGALS2lectin, galactoside-binding, soluble, 2Kidney-6.380.000
104TMEM174transmembrane protein 174Kidney-6.380.000
105SCGB1D2secretoglobin, family 1D, member 2Kidney-6.370.000
106COL4A4collagen, type IV, alpha 4Kidney-6.370.000
107GPR64G protein-coupled receptor 64Kidney+6.340.000
108NEK2NIMA-related kinase 2Kidney+6.330.000
109MUC1mucin 1, cell surface associatedKidney-6.330.000
110HAO2hydroxyacid oxidase 2 (long chain)Kidney-6.330.001
111BIRC5baculoviral IAP repeat containing 5Kidney+6.270.000
112CYS1cystin 1Kidney-6.270.000
113CDCA8cell division cycle associated 8Kidney+6.270.000
115RAB25RAB25, member RAS oncogene familyKidney-6.260.001
116TINAGtubulointerstitial nephritis antigenKidney-6.220.000
117ELF5E74-like factor 5 (ets domain transcription factor)Kidney-6.220.000
118PAPPApregnancy-associated plasma protein A, pappalysin 1Kidney-6.200.004
119MCM10minichromosome maintenance complex component 10Kidney+6.190.000
120TMPRSS2transmembrane protease, serine 2Kidney-6.150.000
121CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)Kidney-6.120.000
122AQP2aquaporin 2 (collecting duct)Kidney-6.120.000
123CYP4A22cytochrome P450, family 4, subfamily A, polypeptide 22Kidney-6.110.003
124DPP4dipeptidyl-peptidase 4Kidney-6.100.000
125LRRN1leucine rich repeat neuronal 1Kidney+6.090.000
126DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Kidney+6.090.000
127SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12Kidney-6.080.000
128CLRN3clarin 3Kidney-6.080.001
131CRABP2cellular retinoic acid binding protein 2Kidney+6.070.000
132PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive)Kidney-6.060.003
133CUBNcubilin (intrinsic factor-cobalamin receptor)Kidney-6.060.000
134LOC100505650uncharacterized LOC100505650Kidney-6.060.001
135DAPL1death associated protein-like 1Kidney+6.050.001
136LRP2low density lipoprotein receptor-related protein 2Kidney-6.050.000
137RHCGRh family, C glycoproteinKidney-6.040.000
138ANPEPalanyl (membrane) aminopeptidaseKidney-6.030.007
139ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Kidney-6.030.000
140TMSB15Athymosin beta 15aKidney+6.010.000
141PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaKidney-6.000.005
143KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16Kidney-5.990.000
144LRRC19leucine rich repeat containing 19Kidney-5.990.001
145UG0898H09uncharacterized LOC643763Kidney+5.980.000
146EHFets homologous factorKidney-5.970.002
147NOS1nitric oxide synthase 1 (neuronal)Kidney-5.970.001
148FGF9fibroblast growth factor 9Kidney-5.970.018
149SLC5A10solute carrier family 5 (sodium/sugar cotransporter), member 10Kidney-5.960.000
150DIO1deiodinase, iodothyronine, type IKidney-5.940.022
152SLC5A12solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12Kidney-5.930.001
153FOXM1forkhead box M1Kidney+5.920.000
154TMEM139transmembrane protein 139Kidney-5.910.000
155SLC22A8solute carrier family 22 (organic anion transporter), member 8Kidney-5.880.000
156CDKN3cyclin-dependent kinase inhibitor 3Kidney+5.880.000
157MACC1metastasis associated in colon cancer 1Kidney-5.860.000
158SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19Kidney-5.860.000
159MST1Lmacrophage stimulating 1-likeKidney-5.860.000
160CTXN3cortexin 3Kidney-5.840.000
161RNF186ring finger protein 186Kidney-5.840.000
162SLC27A2solute carrier family 27 (fatty acid transporter), member 2Kidney-5.840.012
164RGS4regulator of G-protein signaling 4Kidney+5.820.001
165GSTA1glutathione S-transferase alpha 1Kidney-5.810.017
166ACE2angiotensin I converting enzyme 2Kidney-5.800.000
167GAL3ST1galactose-3-O-sulfotransferase 1Kidney-5.780.000
168MAOBmonoamine oxidase BKidney-5.770.008
169HYAL1hyaluronoglucosaminidase 1Kidney-5.770.003
170C1QTNF4C1q and tumor necrosis factor related protein 4Kidney+5.760.000
171DMRT3doublesex and mab-3 related transcription factor 3Kidney+5.760.019
172GPR110G protein-coupled receptor 110Kidney-5.750.003
173LOC100505498uncharacterized LOC100505498Kidney-5.750.001
174CENPMcentromere protein MKidney+5.730.000
175SLC12A3solute carrier family 12 (sodium/chloride transporter), member 3Kidney-5.730.000
176CCDC160coiled-coil domain containing 160Kidney-5.730.000
177GATA3GATA binding protein 3Kidney-5.720.005
178GALNT14polypeptide N-acetylgalactosaminyltransferase 14Kidney-5.700.000
179KIF4Akinesin family member 4AKidney+5.700.000
180BUB1BUB1 mitotic checkpoint serine/threonine kinaseKidney+5.700.001
181PDE1Aphosphodiesterase 1A, calmodulin-dependentKidney-5.690.000
182WDR72WD repeat domain 72Kidney-5.690.000
183TMEM72transmembrane protein 72Kidney-5.690.000
184PRELPproline/arginine-rich end leucine-rich repeat proteinKidney-5.690.004
185RRM2ribonucleotide reductase M2Kidney+5.690.000
186MMEmembrane metallo-endopeptidaseKidney-5.690.004
187PAQR5progestin and adipoQ receptor family member VKidney-5.670.000
188CA12carbonic anhydrase XIIKidney-5.670.000
189NR1H4nuclear receptor subfamily 1, group H, member 4Kidney-5.660.009
190MND1meiotic nuclear divisions 1 homolog (S. cerevisiae)Kidney+5.660.000
191CLDN10claudin 10Kidney-5.660.000
192PIGRpolymeric immunoglobulin receptorKidney-5.660.007
193PTGER3prostaglandin E receptor 3 (subtype EP3)Kidney-5.650.000
194SLC23A1solute carrier family 23 (ascorbic acid transporter), member 1Kidney-5.640.001
195ADTRPandrogen-dependent TFPI-regulating proteinKidney-5.640.000
197ALDH1A1aldehyde dehydrogenase 1 family, member A1Kidney-5.630.009
198TFCP2L1transcription factor CP2-like 1Kidney-5.630.000
199UGT8UDP glycosyltransferase 8Kidney-5.630.008
200CA10carbonic anhydrase XKidney-5.630.004
201MKI67marker of proliferation Ki-67Kidney+5.620.000
202LDHDlactate dehydrogenase DKidney-5.620.001
203ILDR1immunoglobulin-like domain containing receptor 1Kidney-5.620.003
204SHANK2SH3 and multiple ankyrin repeat domains 2Kidney-5.620.003
205KIF14kinesin family member 14Kidney+5.620.000
206VTCN1V-set domain containing T cell activation inhibitor 1Kidney-5.610.001
207FOXQ1forkhead box Q1Kidney-5.610.003
208CDC25Acell division cycle 25AKidney+5.550.002
209MELKmaternal embryonic leucine zipper kinaseKidney+5.520.002
210BMPERBMP binding endothelial regulatorKidney+5.520.001
212GINS4GINS complex subunit 4 (Sld5 homolog)Kidney+5.510.000
213SMPXsmall muscle protein, X-linkedKidney+5.510.002
214APBA2amyloid beta (A4) precursor protein-binding, family A, member 2Kidney+5.510.000
215APOC1apolipoprotein C-IKidney+5.500.005
216CENPKcentromere protein KKidney+5.500.000
217CENPFcentromere protein F, 350/400kDaKidney+5.500.000
218TMEM100transmembrane protein 100Kidney+5.490.001
219TMEFF1transmembrane protein with EGF-like and two follistatin-like domains 1Kidney+5.480.002
220CCNE2cyclin E2Kidney+5.430.001
221FANCIFanconi anemia, complementation group IKidney+5.430.000
222CBX2chromobox homolog 2Kidney+5.420.000
223DLGAP5discs, large (Drosophila) homolog-associated protein 5Kidney+5.420.000
224TEX15testis expressed 15Kidney+5.400.003
225MDKmidkine (neurite growth-promoting factor 2)Kidney+5.370.000
226CDCA2cell division cycle associated 2Kidney+5.350.000
227HJURPHolliday junction recognition proteinKidney+5.320.000
228UBE2Cubiquitin-conjugating enzyme E2CKidney+5.290.000
229CNTNAP2contactin associated protein-like 2Kidney+5.290.002
230FAM64Afamily with sequence similarity 64, member AKidney+5.260.000
231MEX3Bmex-3 RNA binding family member BKidney+5.240.000
232FBXO11F-box protein 11Kidney+5.240.002
233RAD51AP1RAD51 associated protein 1Kidney+5.230.001
234NPTX2neuronal pentraxin IIKidney+5.230.001
235SIX2SIX homeobox 2Kidney+5.210.000
236MEGF10multiple EGF-like-domains 10Kidney+5.190.015
237MAGEL2MAGE-like 2Kidney+5.190.000
238CTHRC1collagen triple helix repeat containing 1Kidney+5.150.000
239ZMAT4zinc finger, matrin-type 4Kidney+5.150.001
240NCAPGnon-SMC condensin I complex, subunit GKidney+5.080.000
241NUSAP1nucleolar and spindle associated protein 1Kidney+5.080.000
242DEPDC1DEP domain containing 1Kidney+5.040.000
243CENPWcentromere protein WKidney+5.040.000
244PRR11proline rich 11Kidney+5.020.000
245NUF2NUF2, NDC80 kinetochore complex componentKidney+4.960.000
246CDH7cadherin 7, type 2Kidney+4.950.002
247ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2Kidney+4.940.000
248CCND2cyclin D2Kidney+4.940.001
249EZH2enhancer of zeste homolog 2 (Drosophila)Kidney+4.930.001
250ETV4ets variant 4Kidney+4.930.000
251HOXA11-ASHOXA11 antisense RNAKidney+4.920.001
252WNT5Bwingless-type MMTV integration site family, member 5BKidney+4.920.000
253AURKAaurora kinase AKidney+4.920.001
254CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)Kidney+4.900.005
255HAS2hyaluronan synthase 2Kidney+4.870.001
256KIF11kinesin family member 11Kidney+4.860.000
257FAT3FAT atypical cadherin 3Kidney+4.840.001
258KCNG1potassium voltage-gated channel, subfamily G, member 1Kidney+4.840.000
259CDCA7cell division cycle associated 7Kidney+4.810.000
260ELOVL2ELOVL fatty acid elongase 2Kidney+4.780.001
261BUB1BBUB1 mitotic checkpoint serine/threonine kinase BKidney+4.770.001
262COL13A1collagen, type XIII, alpha 1Kidney+4.770.000
263CDC45cell division cycle 45Kidney+4.770.001
264DLK1delta-like 1 homolog (Drosophila)Kidney+4.750.026
265TRAIPTRAF interacting proteinKidney+4.750.000
267CCNB1cyclin B1Kidney+4.740.000
268EXO1exonuclease 1Kidney+4.730.000
269MURCmuscle-related coiled-coil proteinKidney+4.730.001
270HIST1H2AGhistone cluster 1, H2agKidney+4.710.000
271MYBPC2myosin binding protein C, fast typeKidney+4.700.007
272GAS1growth arrest-specific 1Kidney+4.700.010
273ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2Kidney+4.690.000
274MMP16matrix metallopeptidase 16 (membrane-inserted)Kidney+4.680.000
275MFAP2microfibrillar-associated protein 2Kidney+4.650.000
276MCM4minichromosome maintenance complex component 4Kidney+4.630.002
277PTTG1pituitary tumor-transforming 1Kidney+4.630.000
278CENPEcentromere protein E, 312kDaKidney+4.620.001
279ST6GAL2ST6 beta-galactosamide alpha-2,6-sialyltranferase 2Kidney+4.600.000
280CDK1cyclin-dependent kinase 1Kidney+4.600.000
281PRC1protein regulator of cytokinesis 1Kidney+4.600.000
282GJC1gap junction protein, gamma 1, 45kDaKidney+4.600.003
283KIF18Bkinesin family member 18BKidney+4.580.002
284DPYSL4dihydropyrimidinase-like 4Kidney+4.580.004
285GINS2GINS complex subunit 2 (Psf2 homolog)Kidney+4.570.003
286TBC1D31TBC1 domain family, member 31Kidney+4.540.000
287CCNA2cyclin A2Kidney+4.540.000
288DPP10dipeptidyl-peptidase 10 (non-functional)Kidney+4.530.007
289TYMSthymidylate synthetaseKidney+4.530.000
290RTKN2rhotekin 2Kidney+4.520.006
291DUSP4dual specificity phosphatase 4Kidney+4.490.000
292CDC20cell division cycle 20Kidney+4.480.000
293ENC1ectodermal-neural cortex 1 (with BTB domain)Kidney+4.470.003
294PLK4polo-like kinase 4Kidney+4.470.003
295NCAPHnon-SMC condensin I complex, subunit HKidney+4.460.001
296SPSB4splA/ryanodine receptor domain and SOCS box containing 4Kidney+4.460.000
297ROBO2roundabout, axon guidance receptor, homolog 2 (Drosophila)Kidney+4.450.003
298FZD2frizzled class receptor 2Kidney+4.440.000
299LMNB2lamin B2Kidney+4.440.001
300PBKPDZ binding kinaseKidney+4.430.000
301CDCA3cell division cycle associated 3Kidney+4.430.000
302MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)Kidney+4.420.000
303MESTmesoderm specific transcriptKidney+4.400.000
304ZNF703zinc finger protein 703Kidney+4.380.000
305C11orf82chromosome 11 open reading frame 82Kidney+4.380.000
306ZNF521zinc finger protein 521Kidney+4.360.000
307TCEAL7transcription elongation factor A (SII)-like 7Kidney+4.350.000
309H2BFXPH2B histone family, member X, pseudogeneKidney+4.320.008
310LAMA4laminin, alpha 4Kidney+4.310.001
311BRCA2breast cancer 2, early onsetKidney+4.310.000
312RPS2ribosomal protein S2Kidney+4.310.000
313TACC3transforming, acidic coiled-coil containing protein 3Kidney+4.300.002
314CASC5cancer susceptibility candidate 5Kidney+4.280.001
315CKS2CDC28 protein kinase regulatory subunit 2Kidney+4.270.000
316ARID3BAT rich interactive domain 3B (BRIGHT-like)Kidney+4.260.000
318FZD10frizzled class receptor 10Kidney+4.240.002
319CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitKidney+4.230.005
320SLC7A11solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11Kidney+4.220.014
321IQGAP3IQ motif containing GTPase activating protein 3Kidney+4.220.002
322GABBR2gamma-aminobutyric acid (GABA) B receptor, 2Kidney+4.210.017
323SPC24SPC24, NDC80 kinetochore complex componentKidney+4.210.000
324TMSB15Bthymosin beta 15BKidney+4.170.001
325HMMRhyaluronan-mediated motility receptor (RHAMM)Kidney+4.170.000
326HOXA11homeobox A11Kidney+4.150.001
327SHISA2shisa family member 2Kidney+4.150.000
328ZNF540zinc finger protein 540Kidney+4.140.000
329RBM24RNA binding motif protein 24Kidney+4.120.001
330LRP4low density lipoprotein receptor-related protein 4Kidney+4.110.001
331OIP5Opa interacting protein 5Kidney+4.110.000
332NMUneuromedin UKidney+4.100.002
333UBE2Tubiquitin-conjugating enzyme E2T (putative)Kidney+4.100.000
334ZNF423zinc finger protein 423Kidney+4.090.001

Search GEO for disease gene expression data for Wilms Tumor.

Pathways for genes affiliated with Wilms Tumor

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Pathways related to Wilms Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1WT1, BRCA2, RRM1

Compounds for genes affiliated with Wilms Tumor

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43Novoseek, 24HMDB
See all sources

Compounds related to Wilms Tumor according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1nap-24310.1H19, NAP1L4
2thymidine43 2411.0WT1, H19, BRCA2, RRM1
3hpaii4310.0WT1, H19

GO Terms for genes affiliated with Wilms Tumor

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Products for genes affiliated with Wilms Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Wilms Tumor

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26ICD10 via Orphanet
34MESH via Orphanet
46OMIM via Orphanet
56SNOMED-CT via Orphanet
61UMLS via Orphanet