Wiskott-aldrich Syndrome malady

Genetics Home Reference: Wiskott-Aldrich syndrome is a condition that affects blood cells and cells of the immune system. This condition is seen almost exclusively in males. Individuals with this condition have microthrombocytopenia, which is a decrease in the number and size of blood cells involved in clotting (platelets). This platelet abnormality, which is typically present from birth, can lead to easy bruising or episodes of prolonged bleeding following minor trauma. Eczema, an inflammatory skin disorder characterized by abnormal patches of red, irritated skin, often occurs in people with this condition. Affected individuals also have an increased risk of infection due to dysfunction of many types of immune cells, such as T cells, B cells, dendritic cells, and natural killer cells. Some people develop autoimmune disorders, which occur when the immune system malfunctions and attacks the body's tissues and organs by mistake. The risk of developing some types of cancer, such as cancer of the immune system cells (lymphoma), is increased in people with Wiskott-Aldrich syndrome.¹⁷

MalaCards: Wiskott-aldrich Syndrome, also known as wiskott aldrich syndrome, is related to acquired immunodeficiency syndrome and thrombocytopenia. An important gene associated with Wiskott-aldrich Syndrome is WASL (Wiskott-Aldrich syndrome-like), and among its related pathways are G-protein signaling_RAC1 in cellular process and G-protein signaling RAC1 in cellular process. The compounds inositol and phenylalanine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and smooth muscle, and related mouse phenotypes are respiratory system and craniofacial.

NIH Rare Diseases: Wiskott Aldrich syndrome is a condition that affects blood cells and cells of the immune system. It is seen almost exclusively in males. The condition is characterized by a tendency to bleed easily, development of an intensely itchy, scaling skin rash (eczema), and severe recurrent infections. Wiskott Aldrich syndrome is caused by mutations in the WAS gene, which is located on the X chromosome. The condition is inherited in an X-linked recessive pattern. The leading treatment option for Wiskott Aldrich syndrome is bone marrow transplantation. Alternative treatments may include surgery to remove the spleen and other more conservative measures such as antibiotics, IVIG, and avoidance of foods which may cause allergic reactions.³⁰

Wikipedia: Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema,...⁴⁴ more...

OMIM: 301000

Aliases & Descriptions:

wiskott-aldrich syndrome 6 7 17 8 33 32 43 wiskott aldrich syndrome 30 16 immunodeficiency 2 30 17 aldrich syndrome 30 17 eczema thrombocytopenia immunodeficiency syndrome 30 eczema-thrombocytopenia-immunodeficiency syndrome 17

wiskott-aldrich syndrome (disorder) 6 wiskott syndrome 6 imd 2 30 imd2 17 was 30

Diseases related to wiskott-aldrich syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 871)

id	Related Disease	Score	Top Affiliating Genes
1	acquired immunodeficiency syndrome	35.5	RECK, KHDRBS1, LCK, CFP, FYN, CD28
2	thrombocytopenia	34.8	RECK, WAS, WASL, CD40LG, CD44, ITGA2
3	common variable immunodeficiency	34.5	SH2D1A, BTK, VAV1, LCK, CD28, CD40LG
4	severe combined immunodeficiency	34.0	ZAP70, LCK, CFP, CD28, CD40LG, GRB2
5	combined immunodeficiency	33.6	ZAP70, LCK, CFP, CD28, CD40LG, GRB2
6	protein s deficiency	33.0	SH2D1A, RECK, WAS, VAV1, BLZF1, ITK
7	hodgkin's lymphoma	31.5	PIK3R1, PIK3CG, SH2D1A, BLZF1, ZAP70, LCK
8	immunodeficiency	31.4	WAS, BTK, BLZF1, ZAP70, LCK, CD28
9	non-hodgkin lymphoma	31.4	SH2D1A, LCK, FSCN1, CD28, CD44, FCER2
10	zap-70 deficiency	30.2	ZAP70, IGHE, SYK
11	b-cell lymphomas	30.2	BTK, BLZF1, ZAP70, FSCN1, CD44, FCER2
12	neutropenia	29.9	WAS, BTK, BLZF1, CD40LG, INPP5D, IL11
13	encephalitis	29.9	PIK3CG, SH2D1A, CD40LG, FCER2, IL4, IFNG
14	burkitt's lymphoma	29.8	SH2D1A, ZAP70, LCK, CD40LG, CD44, INPP5D
15	t-cell leukemia	29.2	PIK3CG, VAV1, BLZF1, ZAP70, LCK, LCP2
16	kaposi's sarcoma	28.8	PIK3CB, PIK3R2, PIK3R1, PIK3CG, RAC1, KDM4A
17	thrombocytopenia, x-linked	28.5	WAS, THPO, GATA1
18	immunodeficiency with hyper igm type 1	28.4	BTK, CD40LG, IL4, IGHE
19	shigellosis	28.4	WAS, WASF1, WASF2, WASL, VASP, RAC1
20	selective iga deficiency disease	27.8	BTK, CD40LG, IL4
21	anaplastic large cell lymphoma	27.8	RECK, ZAP70, MSN, FSCN1, CDC42, CD44
22	acute lymphoblastic leukemia	27.7	RECK, BTK, ZAP70, INPP5D, DYT10, CRKL
23	pulmonary tuberculosis	27.6	CD28, CD40LG, IL2, IL4, IGHE, IFNG
24	human immunodeficiency virus infectious disease	27.6	CD28, CD40LG, IL2, IL4, IFNG, ACTG1
25	bruton-type agammaglobulinemia	27.4	WAS, BTK, ITK, TEC, SRC, PLEK
26	herpes simplex	27.3	PIK3CG, NCL, RECK, RAC1, LCK, CFP
27	breast cancer	27.3	RECK, PAK1, GSN, AKT1, ERBB2, SRC
28	lymphopenia	27.0	ZAP70, LCK, FYN, CD28, IL2, IL4
29	vaccinia	27.0	PIK3CG, NCK1, WAS, WASL, VASP, LCK
30	agammaglobulinemia	26.7	SH2D1A, BTK, CD40LG, IL2, IL4, CXCL12
31	diphtheria	26.7	CD2, CD40LG, IL2, IGHE, IFNG, CRAT
32	gout	26.7	PIK3CB, PIK3R2, PIK3R1, PIK3CG, SH3GL3, NCK1
33	eczema	26.6	WAS, WASL, BTK, CD40LG, ITK, FCER2
34	human t-cell leukemia virus type 1	26.4	BLZF1, LCK, FYN, CD44, IL2, ICAM1
35	neurodegeneration	26.2	PIK3CB, PIK3CG, NCL, BLZF1, BAIAP2, ITSN1
36	dermatitis	26.2	BTK, CD2, CD40LG, ITSN2, FCER2, IL2
37	vaginitis	26.2	SH2D1A, GRB2, IL2, IL4, IGHE, IFNG
38	diffuse infiltrative lymphocytosis syndrome	26.2	ZAP70, CD28, FCER2, IL2
39	b cell deficiency	26.0	BTK, IL4, IGHE, TEC
40	osteopetrosis	25.8	ITGB3, IFNG, SRC, PLEK, NFATC1, TFE3
41	homocysteine	25.7	PIK3R1, CD40LG, ITGA2, ITGB3, MGAT5, IL2
42	tuberculosis	25.4	PIK3CG, SH2D1A, WAS, WASF1, WASF2, WASF3
43	myopathy	25.4	PIK3R1, BLZF1, CD28, CD40LG, GSN, IL4
44	atopy	25.3	CFP, CD28, ITK, FCER2, IL2, IL4
45	stomatitis	25.3	PIK3CG, BLZF1, IL11, IL2, IFNG, CRAT
46	aplastic anemia	25.2	SH2D1A, IL11, IFNG, THPO, PRKG1, GATA1
47	anemia	25.1	SH2D1A, BLZF1, LCK, MSN, CD28, CDC42
48	focal segmental glomerulosclerosis	25.0	RAC1, FYN, CD40LG, CD2AP, FMN1, IL2
49	lymphoproliferative syndrome	25.0	SH2D1A, WAS, ZAP70, LCK, CD40LG, FCER2
50	poliomyelitis	24.8	BTK, CD40LG, IL4, IFNG, ICAM1

Clinical features from OMIM: 301000

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to wiskott-aldrich syndrome:

²²

MGI Mouse Phenotypes related to wiskott-aldrich syndrome:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	TBX21, NFATC1, NFATC2, HCK, GATA1, CBL
2	craniofacial phenotype	MP:0005382	10.1	CSK, SOS1, TFE3, SHROOM3, NFATC2, NFATC1
3	hematopoietic system phenotype	MP:0005397	8.9	CRKL, GATA1, C5AR1, WIPF1, PLEK, NFATC1
4	endocrine/exocrine gland phenotype	MP:0005379	8.8	IFNG, CRKL, SHC1, ELMO1, TKT, IL2
5	liver/biliary system phenotype	MP:0005370	8.6	TNFAIP3, PTPN12, NFATC1, SHROOM3, EGFR, ABL1
6	limbs/digits/tail phenotype	MP:0005371	8.4	PTK2, SRC, CTNNB1, CRKL, NFATC1, PFN1
7	no phenotypic analysis	MP:0003012	8.3	CTTN, CTNNB1, EGFR, ACTB, DNM3, SYK
8	renal/urinary system phenotype	MP:0005367	8.2	ARHGAP1, MGAT5, TNFAIP3, CTNNB1, EGFR, TKT
9	skeleton phenotype	MP:0005390	8.0	NFATC1, CRKL, CTNNB1, SRC, PTPN2, TNFAIP3
10	embryogenesis phenotype	MP:0005380	8.0	SHC1, PFN1, NFATC2, PLCG1, CRKL, CTNNB1
11	normal phenotype	MP:0002873	7.8	ABL1, SHC1, AKT1, EVL, IFNG, IL4
12	reproductive system phenotype	MP:0005389	7.4	SRC, SUV39H1, PTK2, ERBB2, CTTN, SHC1
13	immune system phenotype	MP:0005387	7.0	PTPN2, TFE3, SYK, PSTPIP1, PRKG1, CSK
14	digestive/alimentary phenotype	MP:0005381	6.8	ERBB2, PTK2, PTPN2, TBX21, CTNNB1, CRK
15	mortality/aging	MP:0010768	6.7	NFATC1, TFE3, DNM3, DNM2, DNM1, SYK
16	tumorigenesis	MP:0002006	6.4	ERBB2, PTK2, TBX21, SUV39H1, SRC, SPN
17	integument phenotype	MP:0010771	5.9	CTNNB1, SRC, PTK2, TNFAIP3, ERBB2, AKT1
18	nervous system phenotype	MP:0003631	5.9	SH3KBP1, PFN1, NFATC2, CRKL, CRK, CTNNB1
19	muscle phenotype	MP:0005369	5.6	NFATC2, CRK, CRAT, CTNNB1, PTK2, DOCK3
20	cardiovascular system phenotype	MP:0005385	5.0	BCAR1, IFNG, ICAM1, CBL, EVL, AKT1
21	growth/size phenotype	MP:0005378	4.4	CRAT, CRK, CRKL, PLCG1, NFATC2, PFN1
22	cellular phenotype	MP:0005384	4.3	PIK3CB, RAC1, BCAR1, CIB1, ZAP70, LCK
23	homeostasis/metabolism phenotype	MP:0005376	4.0	PIK3CB, PI4K2A, PIK3R2, PIK3R1, PIK3CG, NCK1

Articles related to wiskott-aldrich syndrome:

(show top 50)    (show all 218)

id	Title	Authors	Year	Affiliating Genes
1	Phenotypic and genotypic correction of WASP gene muta tion in Wiskott-Aldrich syndrome by unrelated cord blood stem cell transplantat ion. (19654965)	Lee Y.H.... Lee H.B.	2009	WAS
2	Clinical aspects and molecular analysis of Chinese patients with Wiskott-Aldrich syndrome in Taiwan. (17703096)	Lee W.I.... Chang K.W.	2008	WAS
3	A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. (17329259)	St-Jean M.... Sygusch J.	2007	ALDOA, WAS
4	The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP). (17205972)	Konno A.... Candotti F.	2007	WAS, WIPF1
5	The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. (17296786)	Maillard M.H.... Snapper S.B.	2007	WAS
6	Two novel mutations identified in the Wiskott-Aldrich syndrome protein gene cause Wiskott-Aldrich syndrome and thrombocytopenia. (17390083)	Andreu N.... Fillat C.	2007	WAS
7	A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. (16511828)	Du W.... Tsuchiya S.	2006	WAS, WIPF1
8	Genotype-proteotype linkage in the Wiskott-Aldrich syndrome. (16002738)	Lutskiy M.I.... Remold-O'Donnell E.	2005	WAS, WIPF1
9	The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. (15728466)	Huang W.... Vyas Y.M.	2005	ZAP70, WAS
10	Phenotypic perturbation of B cells in the Wiskott-Aldrich syndrome. (15654828)	Park J.Y.... Remold-O'Donnell E.	2005	WAS
11	A novel splice site mutation in the WAS gene causes Wiskott-Aldrich syndrome in two siblings of a Saudi family. (15389128)	Abu-Amero K.K.... Al-Hamed M.H.	2004	WAS
12	Confirming or excluding the diagnosis of Wiskott-Aldrich syndrome in children with thrombocytopenia of an unknown etiology. (15218418)	Ariga T.... Sakiyama Y.	2004	WAS
13	Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages. (14504083)	Konno A.... Candotti F.	2004	WAS
14	The Wiskott-Aldrich syndrome. (15378206)	Orange J.S.... Krzewski K.	2004	WAS
15	Polarized hyphal growth in Candida albicans requires the Wiskott-Aldrich Syndrome protein homolog Wal1p. (15075276)	Walther A.... Wendland J.	2004	WAS
16	Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. (12728121)	Dupuis-Girod S.... Fischer A.	2003	CD40LG
17	SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. (12874226)	Zeng R.... Burkhardt J.K.	2003	WAS, NCK1
18	Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott-Aldrich syndrome protein. (12899629)	Schulte R.J.... Sefton B.M.	2003	WAS
19	Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. (12177428)	Orange J.S.... Strominger J.L.	2002	WAS
20	Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. (12437929)	Volkman B.F.... Lim W.A.	2002	WASL, WIPF1
21	An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome. (12073025)	Lutskiy M.I.... Remold-O'Donnell E.	2002	WAS
22	Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. (11830518)	Mizutani K.... Takenawa T.	2002	WASL, CTTN
23	Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation. (12196287)	Dupre L.... Roncarolo M.G.	2002	WAS, CD28
24	A novel protocol to identify mutations in patients with wiskott-Aldrich syndrome. (12367583)	Jones L.N.... Remold-O'Donnell E.	2002	WAS
25	Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. (11952639)	Suzuki T.... Sasakawa C.	2002	WAS, WASL
26	Treatment of severe thrombocytopenia with IL-11 in children with Wiskott-Aldrich syndrome. (11972106)	Braithwaite K.... Cairo M.S.	2002	IL11
27	The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. (11687573)	Vetterkind S.... Preuss U.	2002	WASL, WIPF1
28	Identification of WASP mutations in 14 Spanish families with Wiskott-Aldrich syndrome. (11298372)	Fillat C.... Volpini V.	2001	WAS
29	The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. (11748279)	McGavin M.K.... Siminovitch K.A.	2001	WAS, PAK1, ITSN2
30	Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. (11432863)	Suetsugu S.... Takenawa T.	2001	WASL
31	Novel mutations, no detectable mRNA and familial genetic analysis of the Wiskott-Aldrich syndrome protein gene in six Japanese patients with Wiskott-Aldrich syndrome. (10653325)	Sasahara Y.... Tsuchiya S.	2000	WAS
32	Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. (10713100)	Tian L.... Stewart D.M.	2000	CDC42, WAS, TRIP10
33	GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex. (10781580)	Carlier M.F.... Pantaloni D.	2000	CDC42, GRB2, ACTG1
34	The Wiskott-Aldrich syndrome. (10759756)	Thrasher A.J.... Kinnon C.	2000	WAS
35	Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. (10563804)	Higgs H.N.... Pollard T.D.	1999	WAS, WASF1, WASL
36	Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. (10202051)	Stewart D.M.... Nelson D.L.	1999	WAS, WASF2, WIPF1
37	Recurrent aciclovir-resistant herpes simplex in a chi ld with Wiskott-Aldrich syndrome. (9767251)	Saijo M.... Itoh K.	1998	TKT
38	The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for ti ght binding to Cdc42 and structure formation. (9660763)	Rudolph M.G.... Wittinghofer A.	1998	CDC42, WAS
39	Epstein-Barr virus-associated lymphoproliferative disorder after unrelated bone marrow transplantation in a young child with Wiskott-Aldrich syndrome. (9658436)	Sasahara Y.... Konno T.	1998	WAS
40	Absence of expression of the Wiskott-Aldrich syndrome protein in peripheral blood cells of Wiskott-Aldrich syndrome patients. (9683546)	MacCarthy-Morrogh L.... Kinnon C.	1998	WAS
41	Collagen induces tyrosine phosphorylation of Wiskott-Aldrich syndrome protein in human platelets. (9731041)	Oda A.... Ikeda Y.	1998	WAS, PIK3CG, THPO
42	Mutation analysis of five Japanese families with Wiskott-Aldrich syndrome and determination of the family members' carrier status using three different methods. (9098856)	Ariga T.... Sakiyama Y.	1997	WAS
43	Tyrosine kinase signaling regulates Wiskott-Aldrich syndrome protein function, which is essential for megakaryocyte differentiation. (9040941)	Miki H.... Takenawa T.	1997	WAS, SHC1, DYT10
44	Isolated X-linked thrombocytopenia in two unrelated families is associated with point mutations in the Wiskott-Aldrich syndrome protein gene. (8757563)	de Saint Basile G.... Fischer A.	1996	WAS
45	Identification of WASP mutations, mutation hotspots and genotype-phenotype disparities in 24 patients with the Wiskott-Aldrich syndrome. (8931701)	Greer W.L.... Siminovitch K.A.	1996	WAS
46	Peripheral expansion of V delta 1-J delta 1/J delta 2+ gamma delta T cells and large granular lymphocytes in a patient with Wiskott-Aldrich syndrome. (7645397)	Mizuno Y.... Hara T.	1995	SPN
47	Asparagine-linked sugar chains of erythrocyte membran e glycoproteins from Wiskott-Aldrich syndrome are not impaired. (1543652)	Kondo N.... Orii T.	1992	RECK, GYPB
48	CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. (1683685)	Rosenstein Y.... Burakoff S.J.	1991	ICAM1, SPN
49	Early bone marrow transplantation in an infant with Wiskott-Aldrich syndrome. (1793157)	Beard L.J.... Ferrante A.	1991	IGHE
50	Hereditary X-linked thrombocytopenia maps to the same chromosomal region as the Wiskott-Aldrich syndrome. (2904289)	Donner M.... Holmberg L.	1988	WAS

Genes related to wiskott-aldrich syndrome according to GeneCards:

(show top 50)    (show all 174)

id	Symbol	Description	Score	GeneCards Section Context
1	WASL	Wiskott-Aldrich syndrome-like	11.2	Aliases & Descriptions, Summaries, Transcripts, Publications (show all 7 sections) Orthologs, Proteins, Functions
2	WAS	Wiskott-Aldrich syndrome	11.1	Aliases & Descriptions, Orthologs, Transcripts, Summaries (show all 5 sections) Publications
3	WIPF1	WAS/WASL interacting protein family, member 1	11.1	Orthologs, Publications, Aliases & Descriptions, Summaries
4	WASF1	WAS protein family, member 1	11.1	Publications, Aliases & Descriptions, Summaries
5	WASF2	WAS protein family, member 2	11.1	Summaries, Aliases & Descriptions, Publications
6	WASF3	WAS protein family, member 3	11.1	Aliases & Descriptions, Proteins, Summaries, Publications
7	CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	11.1	Summaries, Publications
8	NCKIPSD	NCK interacting protein with SH3 domain	11.1	Publications, Aliases & Descriptions
9	SNX9	sorting nexin 9	11.1	Publications, Aliases & Descriptions
10	DOCK3	dedicator of cytokinesis 3	11.1	Summaries
11	WASF4P	WAS protein family, member 4, pseudogene	11.1	Summaries
12	WASF5P	WAS protein family, member 5, pseudogene	11.1	Summaries
13	SPN	sialophorin	11.0	Publications
14	ARFRP1	ADP-ribosylation factor related protein 1	11.0	Publications
15	TRIP10	thyroid hormone receptor interactor 10	11.0	Publications
16	TFE3	transcription factor binding to IGHM enhancer 3	11.0	Publications
17	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	11.0	Publications
18	NCK1	NCK adaptor protein 1	11.0	Publications
19	ACTR3	ARP3 actin-related protein 3 homolog (yeast)	11.0	Publications
20	ACTR2	ARP2 actin-related protein 2 homolog (yeast)	11.0	Publications
21	CFP	complement factor properdin	11.0
22	TNK2	tyrosine kinase, non-receptor, 2	11.0
23	BLZF1	basic leucine zipper nuclear factor 1	11.0	Publications
24	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	11.0	Publications
25	BTK	Bruton agammaglobulinemia tyrosine kinase	11.0	Publications
26	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0
27	GRB2	growth factor receptor-bound protein 2	11.0	Publications
28	CTTN	cortactin	11.0	Publications
29	MSN	moesin	11.0	Publications
30	FYN	FYN oncogene related to SRC, FGR, YES	11.0	Publications
31	GATA1	GATA binding protein 1 (globin transcription factor 1)	11.0
32	RHOD	ras homolog family member D	11.0	Publications
33	VASP	vasodilator-stimulated phosphoprotein	11.0
34	GSN	gelsolin	11.0
35	PLCG1	phospholipase C, gamma 1	11.0	Publications
36	PLEK	pleckstrin	11.0	Publications
37	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	11.0	Publications
38	TEC	tec protein tyrosine kinase	11.0	Publications
39	THPO	thrombopoietin	11.0	Publications
40	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	11.0	Publications
41	VAV1	vav 1 guanine nucleotide exchange factor	11.0	Publications
42	BAIAP2	BAI1-associated protein 2	11.0
43	CD28	CD28 molecule	11.0	Publications
44	RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	11.0	Publications
45	POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	11.0
46	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	11.0	Publications
47	MTSS1	metastasis suppressor 1	11.0
48	SYK	spleen tyrosine kinase	11.0	Publications
49	FMN1	formin 1	11.0
50	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0	Publications

Pathways related to wiskott-aldrich syndrome according to GeneDecks:

(show top 50)    (show all 369)

id	Pathway	Score	Top Affiliating Genes
1	G-protein signaling_RAC1 in cellular process41	10.9	ACTR2, ACTR3, ACTB, ARPC2, ARPC3, CDC42
2	G-protein signaling RAC1 in cellular process10	10.9	PAK1, RAC1, WASF2, WASF1, NCK1, BAIAP2
3	Immune response Role of DAP12 receptors in NK cells10	10.8	WIPF1, SYK, ACTR2, ACTR3, ACTB, SHC1
4	Development EGFR signaling pathway10	10.8	CBL
5	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility10	10.8	WASL, ACTG1, ARPC2, ARPC3, CDC42
6	Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases41	10.7	RAC1, WASF1, WAS, PAK1, FSCN1, CDC42
7	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases10	10.7	PFN1, ARPC2, ARPC3, CDC42, FSCN1, PAK1
8	Cell adhesion Cadherin-mediated cell adhesion10	10.7	CDC42, FYN, WASL, FMN1, ACTG1, ACTC1
9	CD28 Signaling in T-Helper Cell36	10.6	TEC, AKT1, ITK, CDC42, CD28, FYN
10	Development Prolactin receptor signaling10	10.5	CBL, GRB2, FYN, RAC1, VAV1, PIK3R1
11	Immune response BCR pathway10	10.5	SOS1, SYK, SHC1, NFATC2, PLCG1, AKT1
12	TCR Signaling36	10.4	CD28, FYN, LCP2, LCK, ZAP70, PAK1
13	Immune response_CD28 signaling41	10.4	CD28, FYN, LCP2, LCK, ZAP70, PAK1
14	Immune response CD28 signaling10	10.3	PAK1, RAC1, VAV1, PIK3R1, PIK3R2, PIK3CB
15	ICos-ICosL Pathway in T-Helper Cell36	10.3	CSK, NFATC2, NFATC1, PIK3R1, VAV1, PLCG1
16	Cytoskeleton remodeling Slit-Robo signaling10	10.3	CDC42, FYN, WASL, ARPC3, ARPC2, PTK2
17	Immune response ICOS pathway in T-helper cell10	10.3	NFATC2, PLCG1, AKT1, GRB2, ITK, CDC42
18	Immune response NFAT in immune response10	10.3	SYK, NFATC2, PIK3CB, PIK3R2, PIK3R1, BTK
19	Internalin Pathway36	10.3	AKT1, CBL, GRB2, ARHGEF7, CDC42, PAK1
20	Development_Slit-Robo signaling41	10.3	FYN, WASL, CDC42, ARPC3, ARPC2, ACTG1
21	Immune response_ICOS pathway in T-helper cell41	10.3	ZAP70, PIK3CG, PIK3CB, LCP2, ITK, AKT1
22	Immune response_CD16 signaling in NK cells41	10.2	PIK3R2, PIK3R1, SHC1, NFATC2, CBL, GRB2
23	Bacterial invasion of epithelial cells20	10.2	DNM1, DNM2, DNM3, ELMO1, ACTG1, ACTB
24	Chemotaxis_CXCR4 signaling pathway41	10.2	SOS1, VAV1, RAC1, BCAR1, CXCL12, SHC1
25	Chemotaxis CXCR4 signaling pathway10	10.2	SOS1, CXCL12, SHC1, CRKL, CRK, SRC
26	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility41	10.1	PIK3CB, PTK2, ARPC2, ARPC3, ITGB3, CDC42
27	Cytoskeleton remodeling Reverse signaling by ephrin B10	10.0	WIPF2, WIPF1, SOS1, CXCL12, ACTG1, ACTR2
28	Immune response_Role of DAP12 receptors in NK cells41	10.0	WIPF1, SOS1, SYK, ACTG1, ACTR2, ACTR3
29	Development_Flt3 signaling41	9.9	PIK3R2, PIK3CB, PIK3R1, VAV1, RAC1, SOS1
30	Immune response_BCR pathway41	9.9	CDC42, RAC1, VAV1, BTK, PIK3R1, PIK3R2
31	Integrin Pathway36	9.7	ACTB, PFN1, PLCG1, CRK, SRC, PTK2
32	Fc epsilon RI signaling pathway20	9.7	SOS1, PLCG1, IL4, GRB2, INPP5D, FYN
33	Adherens junction20	9.7	ACTG1, ACTB, EGFR, CTNNB1, ERBB2, CDC42
34	Cytoskeleton remodeling_Integrin outside-in signaling41	9.6	CTNNB1, SRC, PTK2, AKT1, GRB2, ARPC2
35	Cytoskeleton remodeling Integrin outside-in signaling10	9.6	WIPF2, SOS1, RAC1, WAS, PAK1, ITGA2
36	Transendothelial Migration of Leukocytes36	9.5	TEC, WASF1, WAS, PIK3R1, PIK3R2, BTK
37	Development_VEGF signaling via VEGFR2 - generic cascades41	9.4	SOS1, ACTG1, ACTB, SHC1, NFATC1, PLCG1
38	Chemokine signaling pathway20	9.1	SOS1, CXCL12, HCK, ELMO1, SHC1, CRKL
39	CDC42 Pathway36	9.0	ACTG1, ACTR2, ACTR3, ACTB, EGFR, SRC
40	Regulation of actin cytoskeleton20	9.0	SOS1, CDC42, MSN, BAIAP2, BCAR1, PAK1
41	Immune response CD16 signaling in NK cells10	8.9	GRB2, INPP5D, ARPC2, ARPC3, CDC42, LCK
42	Development_EGFR signaling pathway41	8.9	SOS1, PIK3CB, PIK3R2, PIK3R1, NCK1, EGFR
43	Natural killer cell mediated cytotoxicity20	8.8	SOS1, VAV1, SH2D1A, PIK3CG, PIK3R1, PIK3R2
44	FAK1 Signaling36	8.7	SOS1, ACTG1, ACTB, EGFR, PLCG1, CRK
45	Tyrosine Kinases / Adaptors3	8.6	ITK, FYN, LCP2, LCK, ZAP70, BCAR1
46	T cell receptor signaling pathway20	8.2	PIK3CB, CDC42, CD28, FYN, LCP2, LCK
47	Paxillin Interactions36	7.9	ACTB, EGFR, CRK, SRC, PTPN12, PTK2
48	Tec Kinases Signaling36	7.8	CXCL12, SYK, THPO, ACTG1, ACTB, EGFR
49	ErbB signaling pathway20	7.8	SOS1, ABL1, EGFR, SHC1, PLCG1, CRKL
50	Focal adhesion20	7.4	SOS1, ACTG1, ACTB, EGFR, SHC1, CRKL

Compounds related to wiskott-aldrich syndrome according to GeneDecks:

(show top 50)    (show all 183)

id	Compound	Score	Top Affiliating Genes
1	inositol32	10.7	PIK3CB, SH2D1A, INPP5D, GSN, TEC, SRC
2	phenylalanine32	10.7	PIK3R1, NCK1, BTK, VAV1, BLZF1, ZAP70
3	gdp32	10.6	WAS, VAV1, RAC1, PAK1, ZAP70, LCK
4	phosphatidylserine32 9 9	12.6	RECK, RAC1, ZAP70, LCK, MSN, JMJD6
5	pip232	10.5	PIK3R1, NCK1, WAS, WASL, BTK, RAC1
6	ionomycin32	10.4	PIK3CB, WAS, BTK, VAV1, LCK, FYN
7	phosphatidylinositol-3,4,5-trisphosphate32 18	11.4	PIK3CB, PIK3R1, PIK3CG, BTK, VAV1, RAC1
8	piceatannol32 42 9 9	13.1	PIK3CG, BTK, VAV1, RAC1, ZAP70, LCK
9	fibrinogen32	9.9	PIK3CB, RECK, BTK, VASP, VAV1, RAC1
10	h2o232	9.7	PIK3CB, PIK3R1, PIK3CG, BLZF1, ZAP70, LCK
11	threonine32	9.7	SH2D1A, BTK, VASP, KHDRBS1, BCAR1, ZAP70
12	sb 20358032 42	10.6	BTK, RAC1, CDC42, FCER2, IFNG, PTK2
13	agar32	9.4	PIK3R1, RAC1, BCAR1, CDC42, CD40LG, GRB2
14	proline32	9.4	PIK3R1, NCK1, WAS, WASL, BTK, VASP
15	fmlp32	9.3	PIK3CG, VAV1, RAC1, PAK1, CDC42, GSN
16	pge232	9.3	RAC1, FCER2, PTK2, CRAT, PLCG1, RHOD
17	gtp32	9.2	PIK3R1, RECK, WAS, VAV1, RAC1, BLZF1
18	arginine32	9.1	NCL, RECK, BTK, VAV1, RAC1, BLZF1
19	cysteine32	9.0	RECK, BTK, RAC1, BLZF1, LCK, FYN
20	glucose32	8.9	PAK1, CD2, ITGA2, ARHGEF7, MGAT5, GSN
21	wortmannin32 42	9.8	PIK3CB, PIK3R1, PIK3CG, WAS, BTK, VAV1
22	inositol 1,4,5 trisphosphate32	8.8	PIK3CB, BTK, RAC1, LCK, FYN, CD28
23	cytochalasin d32 42	9.5	PIK3CG, WAS, RAC1, PAK1, BCAR1, LCK
24	ly29400232	8.5	PIK3CB, PIK3R1, PIK3CG, PAK1, BCAR1, CDC42
25	atp32	8.5	PIK3CB, PIK3R1, NCL, RECK, WAS, BTK
26	matrigel32	8.4	PIK3R1, PIK3CG, RAC1, CD44, ITGA2, MGAT5
27	rapamycin32 42	9.4	PIK3CG, WAS, GTDC2, IL2, IFNG, AKT1
28	lipid32	8.2	PIK3CB, PIK3R1, PIK3CG, NCL, RECK, WAS
29	glutamate32	8.2	PIK3CB, PI4K2A, PIK3R1, BLZF1, PAK1, LCK
30	gf 109203x32 42	9.1	PIK3CB, PIK3CG, BTK, ITGA2B, GRB2, DYT10
31	pd 98,05932	7.9	PIK3R1, PIK3CG, NCL, RECK, RAC1, PAK1
32	phosphotyrosine32	7.8	PIK3CB, PIK3R1, PIK3CG, SH2D1A, NCK1, RECK
33	ag 147832	7.8	PIK3CG, ITGA2, GRB2, CBL, AKT1, ERBB2
34	phosphoinositide32	7.7	PIK3CB, PIK3R2, PIK3R1, PIK3CG, NCK1, WASL
35	adp32 18	8.6	PIK3CB, PIK3CG, RECK, WAS, WASL, BTK
36	calcium32 9 18 9	10.5	PIK3CB, PIK3R1, SH2D1A, NCL, RECK, WAS
37	estrogen32	7.4	PIK3CB, PIK3R1, NCL, PAK1, BCAR1, MSN
38	histamine32 18	8.3	BTK, CD40LG, INPP5D, FCER2, IL11, IL2
39	cyclosporin a32 42	8.3	PIK3CG, RECK, VAV1, BLZF1, LCK, FYN
40	imatinib32 34 9 9	10.0	PIK3R1, PIK3CG, ZAP70, LCK, IL4, ICAM1
41	dexamethasone32 42 34 9 9	10.9	PIK3R1, VAV1, ZAP70, LCK, CD28, CD40LG
42	tamoxifen32 34 9 9	9.8	PAK1, BCAR1, CD44, GRB2, IL2, AKT1
43	genistein32 9 18 9	9.8	PIK3R1, PIK3CG, BTK, RAC1, BLZF1, BCAR1
44	vegf32	6.5	PIK3CB, PIK3R1, PIK3CG, NCK1, RECK, WASL
45	phosphatidylinositol32	6.3	PIK3CB, PI4K2A, PIK3R2, PIK3R1, PIK3CG, NCK1
46	retinoic acid32 42 18	8.0	PIK3CG, NCL, VAV1, RAC1, BLZF1, FYN
47	herbimycin a32 42	6.5	PIK3CG, VAV1, BCAR1, LCK, FYN, CD28
48	cycloheximide32	5.3	PIK3R1, PIK3CG, RAC1, BLZF1, LCK, MSN
49	serine32	5.1	PIK3CB, PIK3R1, PIK3CG, NCK1, NCL, RECK
50	tyrosine32	3.5	PIK3CB, PIK3R1, PIK3CG, SH2D1A, NCK1, NCL

Cellular components related to wiskott-aldrich syndrome according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	actin cytoskeleton	GO:015629	10.8	ARPC2, GSN, FGR, ALDOA, NFATC2, PFN1
2	filopodium	GO:030175	10.6	CIB1, BAIAP2, MSN, FSCN1, CDC42
3	lamellipodium	GO:030027	10.5	AKT1, PTK2, CTTN, PLCG1, ACTR3, PSTPIP1
4	ruffle	GO:001726	10.5	PLCG1, SNX9, CTTN, GSN, ARHGEF7, CD2AP
5	Arp2/3 protein complex	GO:005885	10.4	ACTR2, ACTR3, ARPC2, ARPC3
6	actin filament	GO:005884	10.4	WIPF1, HCK, ACTC1, ACTR3, RHOQ, INPP5D
7	cytoskeleton	GO:005856	9.9	SH3KBP1, SHROOM3, ACTB, ACTG1, ELMO1, TGFB1I1
8	focal adhesion	GO:005925	9.7	EVL, PTK2, SH3KBP1, HCK, TGFB1I1, ARPC2
9	cell cortex	GO:005938	9.3	CTNNB1, CTTN, PTK2, TRIP10, ARHGEF7, FNBP1
10	external side of plasma membrane	GO:009897	8.5	IL4, IFNG, ICAM1, SPN, CXCL12, FCER2
11	cytosol	GO:005829	6.9	PLCG1, ACTG1, ELMO1, HCK, TKT, DNM2
12	cytoplasm	GO:005737	6.5	CTNNB1, CRK, PLCG1, PLEK, NFATC1, NFATC2
13	plasma membrane	GO:005886	5.7	TNK2, TEC, PTPN12, SRC, SPN, CTNNB1

Biological processes related to wiskott-aldrich syndrome according to GeneDecks:

(show all 47)

id	Name	GO ID	Score	Top Affiliating Genes
1	actin filament polymerization	GO:030041	11.0	GSN, RAC1, WASF3, WASF1, WAS
2	actin polymerization or depolymerization	GO:008154	11.0	WIPF1, EVL, VASP, WASL, WAS
3	positive regulation of actin filament polymerization	GO:030838	11.0	HCK, ACTR3, GRB2, ARPC2, FMN1, RAC1
4	T cell costimulation	GO:031295	10.8	LCK, PAK1, RAC1, VAV1, PIK3R1, PIK3R2
5	actin filament-based movement	GO:030048	10.7	WIPF1, ACTC1, WASF2, WAS
6	B cell receptor signaling pathway	GO:050853	10.7	SYK, NFATC2, TEC, BCAR1, BTK
7	filopodium assembly	GO:046847	10.7	DNM3, ASAP1, CDC42, MTSS1, BAIAP2
8	regulation of phagocytosis	GO:050764	10.6	SYK, HCK, FGR
9	small GTPase mediated signal transduction	GO:007264	10.6	SOS1, RHOQ, RHOD, RND2, TNK2, TRIP10
10	T cell activation	GO:042110	10.6	ITK, CD2, ZAP70, VAV1, WAS, NCK1
11	protein complex assembly	GO:006461	10.6	WIPF1, CD2AP, SF3B3, WASL, WASF3, WASF1
12	regulation of defense response to virus by virus	GO:050690	10.6	HCK, ELMO1, CD28, FYN, LCK, RAC1
13	regulation of small GTPase mediated signal transduction	GO:051056	10.6	SOS1, RHOQ, RHOD, TRIP10, ARHGAP1, ARHGEF7
14	T cell receptor signaling pathway	GO:050852	10.6	VASP, PAK1, BCAR1, ZAP70, LCK, LCP2
15	fibroblast growth factor receptor signaling pathway	GO:008543	10.5	SOS1, PRKAR2A, SHC1, PLCG1, SRC, AKT1
16	GTP catabolic process	GO:006184	10.4	DNM1, DNM3, RHOQ, RHOD, RND2, ARFRP1
17	peptidyl-tyrosine phosphorylation	GO:018108	10.4	SYK, HCK, ABL1, SRC, PTK2, FGR
18	induction of apoptosis by extracellular signals	GO:008624	10.3	SOS1, SPN, ARHGEF7, ITSN1, RAC1, VAV1
19	phosphatidylinositol biosynthetic process	GO:006661	10.3	INPP5D, PI4K2B, PIK3CG, PIK3R1, PIK3R2, PI4K2A
20	insulin receptor signaling pathway	GO:008286	10.3	PTPN2, CRK, RHOQ, SHC1, SOS1, AKT1
21	platelet aggregation	GO:070527	10.3	GATA1, PLEK, ITGB3, PIK3CG, PIK3CB
22	virus-host interaction	GO:019048	10.3	SUV39H1, SRC, PLCG1, HCK, SYK, HNRNPK
23	cellular component movement	GO:006928	10.3	ACTB, ACTR3, ACTR2, ACTG1, ELMO1, IFNG
24	nerve growth factor receptor signaling pathway	GO:048011	10.2	AKT1, SRC, CRK, PLCG1, SHC1, PRKAR2A
25	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.2	CD44, ITGB3, IL11, TNK2, SYK, GATA1
26	integrin-mediated signaling pathway	GO:007229	10.1	SYK, HCK, PLEK, PTK2, TEC, FGR
27	regulation of cell shape	GO:008360	10.1	HCK, SHROOM3, SH3KBP1, WASF3, FYN, FGR
28	adaptive immune response	GO:002250	10.0	PIK3CG, BTK, ZAP70, ITK, IFNG, SYK
29	phosphatidylinositol-mediated signaling	GO:048015	10.0	PIK3CB, PIK3R2, PIK3R1, GSN, AKT1, ERBB2
30	leukocyte migration	GO:050900	10.0	SOS1, SHC1, PIK3CB, PIK3R2, PIK3R1, LCK
31	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.0	AKT1, IL11, CD44, CDC42, PAK1
32	actin cytoskeleton organization	GO:030036	9.9	PRKG1, ELMO1, ABL1, SHROOM3, PFN1, TRIP10
33	negative regulation of epidermal growth factor receptor signaling pathway	GO:042059	9.8	EGFR, SH3KBP1, CBL, GRB2, ARHGEF7, CDC42
34	endocytosis	GO:006897	9.7	PIK3CB, PIK3CG, SH3GL3, WASF2, PACSIN1, PACSIN3
35	positive regulation of T cell proliferation	GO:042102	9.7	NCK1, CD28, IL4, IFNG, SPN
36	protein phosphorylation	GO:006468	9.6	TEC, HCK, SYK, PRKG1, CSK, POLR2L
37	phosphatidylinositol 3-kinase cascade	GO:014065	9.4	ERBB2, PIK3CG, PIK3R1, PIK3CB
38	positive regulation of isotype switching to IgG isotypes	GO:048304	9.3	TBX21, IFNG, IL4, IL2
39	cell adhesion	GO:007155	9.2	SRC, CTNNB1, ABL1, HCK, TGFB1I1, PSTPIP1
40	platelet activation	GO:030168	9.2	ITGA2B, SYK, SOS1, CSK, THPO, SHC1
41	protein autophosphorylation	GO:046777	9.1	SYK, HCK, EGFR, PTK2, ERBB2, AKT1
42	epidermal growth factor receptor signaling pathway	GO:007173	9.1	PLCG1, SH3KBP1, SHC1, EGFR, PRKAR2A, SOS1
43	cell surface receptor signaling pathway	GO:007166	9.0	ERBB2, TNK2, SPN, EGFR, EVL, CBL
44	axon guidance	GO:007411	8.5	ERBB2, PTK2, SRC, PLCG1, EGFR, ABL1
45	apoptotic process	GO:006915	8.4	AKT1, PTK2, CTNNB1, SH3KBP1, ABL1, ACTC1
46	blood coagulation	GO:007596	8.4	PIK3CB, ITGA2, ITGA2B, ITGB3, INPP5D, FGR
47	signal transduction	GO:007165	8.1	EGFR, RND2, PLCG1, SPN, SRC, DNM2

Molecular functions related to wiskott-aldrich syndrome according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	actin binding	GO:003779	11.2	PFN1, WASL, WASH6P, WASH1, WASF3, WASF2
2	neurotrophin TRKA receptor binding	GO:005168	10.5	PIK3R1, GRB2, PLCG1, SHC1
3	profilin binding	GO:005522	10.4	VASP, EVL, RHOQ, WIPF1
4	phosphotyrosine binding	GO:001784	10.4	SHC1, CBL, GRB2, FGR, ZAP70
5	SH3/SH2 adaptor activity	GO:005070	10.3	CRKL, CRK, SRC, GRB2, ARHGAP1, ITSN2
6	ephrin receptor binding	GO:046875	10.2	SHC1, CRK, SRC, CBL, GRB2, FYN
7	proline-rich region binding	GO:070064	10.2	CSK, ABL1, PFN1, ITSN1, BAIAP2, SH3D19
8	non-membrane spanning protein tyrosine kinase activity	GO:004715	10.1	CSK, LCK, ZAP70, BTK, FYN, ITK
9	SH3 domain binding	GO:017124	9.7	WIPF3, ELMO1, ABL1, SH3KBP1, PTPN12, DOCK3
10	phospholipid binding	GO:005543	9.4	SHC1, ELMO1, DNM3, DNM2, DNM1, SOS1
11	protein kinase binding	GO:019901	9.3	GRB2, PTK2, ACTB, DNM2, SYK, FGR
12	identical protein binding	GO:042802	9.1	ALDOA, AKT1, ERBB2, TRIP10, EGFR, ACTG1
13	protein tyrosine kinase activity	GO:004713	9.1	SHC1, EGFR, ABL1, HCK, CSK, SRC
14	protein phosphatase binding	GO:019903	9.0	CSK, EGFR, CTNNB1, ERBB2, GRB2, BCAR1
15	ATP binding	GO:005524	7.3	ACTB, ABL1, EGFR, SRC, PTK2, ACTR3
16	protein binding	GO:005515	3.7	GATA1, WIPF2, WIPF1, CPSF7, TGFB1I1, TSG101