WAS
MCID: WSK001
MIFTS: 87

Wiskott-Aldrich Syndrome (WAS) malady

Immune diseases, Skin diseases, Blood diseases, Cancer diseases categories

Summaries for Wiskott-Aldrich Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Wiskott aldrich syndrome is a condition that affects blood cells and cells of the immune system. it is seen almost exclusively in males. the condition is characterized by a tendency to bleed easily, development of an intensely itchy, scaling skin rash (eczema), and severe recurrent infections. wiskott aldrich syndrome is caused by mutations in the was gene, which is located on the x chromosome. the condition is inherited in an x-linked recessive pattern. the leading treatment option for wiskott aldrich syndrome is bone marrow transplantation. alternative treatments may include surgery to remove the spleen and other more conservative measures such as antibiotics, ivig, and avoidance of foods which may cause allergic reactions. last updated: 10/27/2010

MalaCards: Wiskott-Aldrich Syndrome, also known as wiskott aldrich syndrome, is related to thrombocytopenia and agammaglobulinemia, and has symptoms including platelets function anomaly, polynuclear cells/neutrophils anomalies/neutropenia and arthritis/synovitis/synovial proliferation. An important gene associated with Wiskott-Aldrich Syndrome is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Immune System. The compounds tyrosine and proline have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related mouse phenotypes are cellular and immune system.

Genetics Home Reference:21 Wiskott-Aldrich syndrome is characterized by abnormal immune system function (immune deficiency) and a reduced ability to form blood clots. This condition primarily affects males.

Wikipedia:63 Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema,... more...

Description from OMIM:46 301000,277970,600903,614493

Aliases & Classifications for Wiskott-Aldrich Syndrome

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 39NCIt, 34MeSH, 27ICD9CM, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases, Skin diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
wiskott-aldrich syndrome:
Inheritance: X-linked recessive; Prevalence: 1-9/1000000; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

wiskott-aldrich syndrome 8 9 21 46 10 44 48 30 60
wiskott aldrich syndrome 42 20 22
eczema-thrombocytopenia-immunodeficiency syndrome 21 48
immunodeficiency 2 42 21
wiskott syndrome 8 21
was 42 48
eczema thrombocytopenia immunodeficiency syndrome 42
aldrich syndrome 42
imd 2 42
imd2 21


External Ids:

Disease Ontology8 DOID:9169
NCIt39 C3448
ICD9CM27 279.12
SNOMED-CT56 36070007
ICD10 via Orphanet26 D82.0
SNOMED-CT via Orphanet57 36070007
UMLS via Orphanet61 C0043194
MESH via Orphanet35 D014923
ICD1025 D82.0

Related Diseases for Wiskott-Aldrich Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Wiskott-Aldrich Syndrome family:

Wiskott-Aldrich Syndrome 2

Diseases related to Wiskott-Aldrich Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 948)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.4WAS, SPN
2agammaglobulinemia30.3CFP, BTK
3alzheimer's disease30.3DOCK3
4shigellosis29.7WASL
5n syndrome10.9
6neuronitis10.6
7hyperlipidemia type 310.6
8aortic aneurysm10.6
9b cell deficiency10.6
10herpes simplex10.6
11purpura10.5
12thoracic aortic aneurysm10.5
13dermatitis10.5
14hodgkin's lymphoma10.5
15t cell deficiency10.5
16non-hodgkin lymphoma10.4
17iga glomerulonephritis10.4
18atopic dermatitis10.4
19thrombotic thrombocytopenic purpura10.4
20progressive multifocal leukoencephalopathy10.4
21adult syndrome10.4
22glomerulonephritis10.4
23neutropenia10.4
24vasculitis10.4
25x-linked disease10.4
26wiskott-aldrich syndrome 210.4
27bone fracture10.2
28neurofibromatosis10.2
29autoimmune thrombocytopenic purpura10.2
30autoimmune thyroiditis10.2
31molluscum contagiosum10.2
32vaccinia10.2
33eclampsia10.2
34juvenile xanthogranuloma10.2
35cerebritis10.2
36juvenile myelomonocytic leukemia10.2
37systemic lupus erythematosus10.2
38common variable immunodeficiency10.2
39acute retinal necrosis syndrome10.2
40platelet storage pool deficiency10.2
41pharyngitis10.2
42fanconi syndrome10.2
43familial melanoma10.2
44intussusception10.2
45ulcerative colitis10.2
46kaposi's sarcoma10.2
47kawasaki disease10.2
48sclerosing cholangitis10.2
49lymphoplasmacytic lymphoma10.2
50adenocarcinoma10.2

Graphical network of the top 20 diseases related to Wiskott-Aldrich Syndrome:



Diseases related to wiskott-aldrich syndrome

Clinical Features for Wiskott-Aldrich Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

301000,277970,600903,614493

Clinical synopsis from OMIM:

277970

Symptoms:

48 (show all 50)
  • platelets function anomaly
  • polynuclear cells/neutrophils anomalies/neutropenia
  • arthritis/synovitis/synovial proliferation
  • hyperostosis
  • meningitis/meningeal syndrome
  • encephalitis
  • intracranial/cerebral/meningeal hemorrhage
  • mucosal/cutaneous hemorrhage
  • internal hemorrhage
  • neoplasms/tumors
  • lymphoma
  • myeloproliferative syndrome/chronic leukemia
  • early death/lethality
  • sepsis severe/septicemia
  • platelets shape anomalies
  • peripheral neuropathy
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • hemolytic anemia
  • anaemia
  • autoimmunity/autoimmune reaction/autoantibodies
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • inflammatory intestinal disease
  • fever/chilling
  • x-linked recessive inheritance
  • thrombocytopenia/thrombopenia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • bruisability
  • chronic obstructive pulmonary disease/copd/obstructive respiratory syndrome
  • repeat respiratory infections
  • purpura/petichiae
  • chronic/relapsing otitis
  • microcytic anemia
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • renal glomerular defect/glomerulopathy
  • renal disease/nephropathy
  • thymic aplasia/hypoplasia
  • vascularitis/vasculitides/arteritis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • cardiac rhythm disorder/arrhythmia
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • thoracic/chest pain
  • urticaria
  • chronic skin infection/ulcerations/ulcers/cancrum
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • asthenia/fatigue/weakness
  • gingivorrhagia/gingival bleeding
  • epistaxis/nose bleeding
  • hematomas
  • nasal congestion/sinusitis/rhinitis/rhinorrhea

Drugs & Therapeutics for Wiskott-Aldrich Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Wiskott-Aldrich Syndrome

Drug clinical trials:

Search ClinicalTrials for Wiskott-Aldrich Syndrome

Search NIH Clinical Center for Wiskott-Aldrich Syndrome

Search CenterWatch for Wiskott-Aldrich Syndrome

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Wiskott-Aldrich Syndrome cell therapies at LifeMap Discovery.

Genetic Tests for Wiskott-Aldrich Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Wiskott-Aldrich Syndrome:

id Genetic test Affiliating Genes
1 Wiskott-Aldrich Syndrome20 22 WAS

Anatomical Context for Wiskott-Aldrich Syndrome

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32MalaCards
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MalaCards organs/tissues related to Wiskott-Aldrich Syndrome:

32
Bone, Bone marrow, Skin, T cells, Spleen, B cells, Lung, Nk cells, Breast, Smooth muscle, Endothelial, Eye, Brain, Cortex, Kidney, Liver, Thyroid, Testis, Monocytes

Animal Models for Wiskott-Aldrich Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Wiskott-Aldrich Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.0WASL, WAS, ARFRP1, NCKIPSD, NCK1, BTK
2MP:000538710.9SPN, WIPF1, WASL, WAS, TFE3, DOCK3
3MP:000539710.6WIPF1, WASL, WAS, WASF3, TFE3, TRIP10

Publications for Wiskott-Aldrich Syndrome

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50PubMed
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Articles related to Wiskott-Aldrich Syndrome:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Wiskott-Aldrich syndrome caused by a new mutation associated with multifocal dermal juvenile xanthogranulomas. (23157619)
2013
2
c-Src and neural Wiskott-Aldrich syndrome protein (N-WASP) promote low oxygen-induced accelerated brain invasion by gliomas. (24069415)
2013
3
Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. (24369837)
2013
4
Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity. (24338698)
2013
5
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. (23141740)
2013
6
Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions. (23212915)
2013
7
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. (22431569)
2012
8
Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells. (22441674)
2012
9
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. (22411869)
2012
10
An unusual self-limited clonal Mott cell proliferation with lymphoplasmacytic lymphoma-like features in a child with the Wiskott-Aldrich syndrome and Von Recklinghausen's neurofibromatosis. (19713050)
2010
11
A novel WASP gene mutation in a Chinese boy with Wiskott-Aldrich syndrome. (20683686)
2010
12
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42. (19561083)
2009
13
Revertant somatic mosaicism in the Wiskott-Aldrich syndrome. (19129986)
2009
14
Multiple independent second-site mutations in two siblings with somatic mosaicism for Wiskott-Aldrich syndrome. (18479478)
2008
15
Novel membrane cell projection defects in Wiskott-Aldrich syndrome B cells. (17786274)
2007
16
Impaired LPS-induced signaling in microglia overexpressing the Wiskott-Aldrich syndrome protein N-terminal domain. (17698982)
2007
17
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. (17764675)
2007
18
Requirement for a complex of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein in podosome formation in macrophages. (17312144)
2007
19
Current understanding of the Wiskott-Aldrich syndrome and prospects for gene therapy. (20477109)
2007
20
A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. (17329259)
2007
21
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. (16804117)
2006
22
Stable mixed chimerism after hematopoietic stem cell transplantation in Wiskott-Aldrich syndrome. (16677369)
2006
23
Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients. (17082665)
2006
24
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. (15834156)
2005
25
Gene symbol: WAS. Disease: Wiskott-Aldrich syndrome. (15991318)
2005
26
Wiskott-Aldrich syndrome complicated by an atypical lymphoproliferative disorder: a case report. (16118678)
2005
27
Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells. (15240657)
2004
28
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. (14707117)
2004
29
X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP). (12591280)
2003
30
Malignant B cell non-Hodgkin's lymphoma of the larynx in children with Wiskott Aldrich syndrome. (12907055)
2003
31
Prenatal diagnosis and genetic analysis of Wiskott-Aldrich syndrome. (14663840)
2003
32
The Wiskott-Aldrich syndrome. (12040832)
2002
33
Non-myeloablative bone marrow transplantation in an adult with Wiskott-Aldrich syndrome. (11841458)
2002
34
The Wiskott-Aldrich syndrome. (11269229)
2001
35
Wiskott-Aldrich syndrome protein and platelets. (11213795)
2000
36
Structural basis of Wiskott-Aldrich syndrome causing mutations in the WH1 domain. (11140379)
2000
37
The cytoskeletal linker protein moesin: decreased levels in Wiskott-Aldrich syndrome platelets and identification of a cleavage pathway in normal platelets. (10444190)
1999
38
The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex. (10339430)
1999
39
Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. (10563804)
1999
40
Pathological events in platelets of Wiskott-Aldrich syndrome patients. (10519987)
1999
41
Recent advances in our understanding of Wiskott-Aldrich syndrome. (9915548)
1999
42
Long-term treatment of refractory thrombocytopenia in a patient with Wiskott-Aldrich syndrome with vincristine, immunoglobulin, and methylprednisolone. (10539885)
1999
43
X-linked Wiskott-Aldrich syndrome in a girl. (9634368)
1998
44
Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri. (9582270)
1998
45
Mutation analysis of five Japanese families with Wiskott-Aldrich syndrome and determination of the family members' carrier status using three different methods. (9098856)
1997
46
The identification of Bruton's tyrosine kinase and Wiskott-Aldrich syndrome protein associated proteins and signalling pathways. (9191173)
1997
47
Successful bone marrow transplantation in a Chinese boy with Wiskott-Aldrich syndrome. (8980801)
1996
48
Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome. (8906743)
1996
49
Sialophorin (CD43) and the Wiskott-Aldrich syndrome. (2223062)
1990
50
Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. (2784859)
1989

Genetic Variations for Wiskott-Aldrich Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Wiskott-Aldrich Syndrome:

62 (show all 19)
id Symbol AA change Variation ID SNP ID
1WASp.Glu31LysVAR_005825
2WASp.Ser82ProVAR_005829
3WASp.Arg86HisVAR_005830
4WASp.Arg86LeuVAR_005831
5WASp.Arg86CysVAR_005832
6WASp.Trp97CysVAR_005833
7WASp.Glu131LysVAR_005834rs146220228
8WASp.Glu133LysVAR_005835
9WASp.Gly187CysVAR_005836
10WASp.Lys476GluVAR_005838
11WASp.Cys43TrpVAR_008105
12WASp.Thr45MetVAR_008106
13WASp.Cys73ArgVAR_008107
14WASp.Phe84LeuVAR_008109
15WASp.Gly89AspVAR_008110
16WASp.Gln52HisVAR_012710
17WASp.Gly70TrpVAR_012711
18WASp.Pro58LeuVAR_022806
19WASp.Ala134ThrVAR_022807

Expression for genes affiliated with Wiskott-Aldrich Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wiskott-Aldrich Syndrome

Search GEO for disease gene expression data for Wiskott-Aldrich Syndrome.

Pathways for genes affiliated with Wiskott-Aldrich Syndrome

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53Reactome, 4Cell Signaling Technology, 12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0CDC42, WIPF1, WASF1, WASL, WASF2, WAS
2
Hide members
11.0WIPF1, WASF1, WASL, WASF2, WAS, WASF3
310.8WASL, WASF2, WAS, WASF3, NCK1, CDC42
4
Cytoskeleton remodeling CDC42 in cellular processes
Hide members
10.8WASF1, WASL, WASF2, WAS, NCK1, CDC42
510.8WASF1, WASL, WASF2, WAS, WASF3, CDC42
610.8WASF1, WASL, WASF2, WAS, WASF3, CDC42
7
Hide members
10.8WASL, WAS, NCK1, BTK, CDC42, ACTR2
8
Hide members
10.8WASF1, WASL, WAS, BTK, CDC42, ACTR2
9
Hide members
10.8WASF1, WASL, WAS, NCK1, CDC42, ACTR2
10
Hide members
10.8WASF1, WASL, WASF3, BTK, CDC42, ACTR2
11
Hide members
10.7WIPF1, WAS, BTK, CDC42, ACTR2
1210.7WASF1, WASL, WASF2, WAS, CDC42
1310.7WASF1, WASL, WASF2, WAS, CDC42
14
Hide members
10.7WASF1, WASL, WASF2, WAS, CDC42
1510.7WASF1, WASL, WASF2, WAS, CDC42
16
Development Slit-Robo signaling
Hide members
10.7ACTR2, CDC42, NCK1, WAS, WASL
17
Hide members
10.7WASF1, WAS, BTK, CDC42, ACTR2
18
Cell adhesion Integrin-mediated cell adhesion and migration
Hide members
10.7WASF1, WASL, WAS, CDC42, ACTR2
19
Hide members
10.7WASF1, WASL, WASF2, CDC42, ACTR2
20
Hide members
10.7CDC42, BTK, NCK1, WAS
2110.7ACTR2, BTK, NCK1, WAS
2210.7ACTR2, CDC42, WAS, WASF1
23
Hide members
10.7ACTR2, CDC42, WAS, WASF1
2410.7WASL, NCK1, CDC42, ACTR2
2510.7ACTR2, CDC42, WASF2, WASL
2610.6WAS, NCK1, CDC42
2710.6WASL, WAS, CDC42
2810.6DOCK3, NCK1, CDC42
29
Cytoskeleton remodeling Reverse signaling by ephrin B
Hide members
10.6ACTR2, WASL, WIPF1
30
Cell adhesion Ephrins signaling
Hide members
10.6CDC42, NCK1, WASL
31
Hide members
10.6WAS, CDC42, ACTR2
3210.6WASL, CDC42, ACTR2
3310.6WASL, CDC42, ACTR2
3410.6NCK1, WASL
3510.6NCK1, WASL
36
Cytoskeleton remodeling Role of PDGFs in cell migration
Hide members
10.6CDC42, WASL

Compounds for genes affiliated with Wiskott-Aldrich Syndrome

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44Novoseek, 59Tocris Bioscience
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Compounds related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4411.1WASL, WASF2, WAS, SNX9, NCK1, TRIP10
2proline4410.9WIPF1, WASL, WAS, TFE3, NCK1, BTK
3pip24410.9CDC42, BTK, NCK1, WAS, WASL
4wiskostatin4410.8WASL, WAS, CDC42
5phosphatidylinositol4410.7WAS, NCK1, BTK, CDC42, WASL
6latex4410.7WASL, WAS, CDC42
7phosphoinositide4410.6WASL, NCK1, BTK, CDC42
8jasplakinolide44 5911.6CDC42, WASL
9cytochalasin d44 5911.3CDC42, WAS, WASL

GO Terms for genes affiliated with Wiskott-Aldrich Syndrome

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16Gene Ontology
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Cellular components related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582911.1WIPF1, WASL, WASF2, WAS, NCKIPSD, NCK1
2actin cytoskeletonGO:01562910.9ACTR2, WIPF1, WASF1, WASL, WASF2, WAS
3actin capGO:03047810.6ACTR2, WASL
4ruffleGO:00172610.6WIPF1, WASF2, SNX9
5lamellipodiumGO:03002710.6WASF3, WASF2, WASL
6vesicle membraneGO:01250610.5NCK1, WAS
7cytoplasmic membrane-bounded vesicleGO:01602310.3SNX9, WASL, WIPF1

Biological processes related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508711.3WIPF1, WASL, WASF2, WAS, NCKIPSD, NCK1
2Fc-gamma receptor signaling pathway involved in phagocytosisGO:03809611.2ACTR2, WIPF1, WASL, WASF2, WAS, NCKIPSD
3protein complex assemblyGO:00646111.0WIPF1, WASF1, WASL, WAS, WASF3
4actin polymerization or depolymerizationGO:00815410.9WAS, WASL, WIPF1
5actin filament-based movementGO:03004810.8WIPF1, WASF2, WAS
6actin filament polymerizationGO:03004110.8WASF3, WAS, WASF1
7establishment or maintenance of cell polarityGO:00716310.8CDC42, ACTR2, SPN
8lamellipodium assemblyGO:03003210.8NCK1, WASF3, WASF2
9spindle localizationGO:05165310.6ACTR2, WASL
10actin cytoskeleton organizationGO:03003610.6CDC42, TRIP10, WASF2
11response to other organismGO:05170710.6WIPF1, NCK1
12cellular component movementGO:00692810.5ACTR2, WASL, WASF1
13small GTPase mediated signal transductionGO:00726410.4ARFRP1, DOCK3, TRIP10, CDC42

Molecular functions related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.2WASF1, WASL, WASF2, WAS, ARFRP1, DOCK3
2actin bindingGO:00377910.6ACTR2, WIPF1, WASF1, WASL, WASF2, WAS

Products for genes affiliated with Wiskott-Aldrich Syndrome

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Sources for Wiskott-Aldrich Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet