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WAS
MCID: WSK001
MIFTS: 76

Wiskott-Aldrich Syndrome (WAS) malady

Immune, Skin, Blood, Cancer categories
50 symptoms, 189 genes, 18 tissues, 864 related diseases, clinical trials, genetic tests.

Summaries for Wiskott-Aldrich Syndrome

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21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Wiskott aldrich syndrome is a condition that affects blood cells and cells of the immune system. it is seen almost exclusively in males. the condition is characterized by a tendency to bleed easily, development of an intensely itchy, scaling skin rash (eczema), and severe recurrent infections. wiskott aldrich syndrome is caused by mutations in the was gene, which is located on the x chromosome. the condition is inherited in an x-linked recessive pattern. the leading treatment option for wiskott aldrich syndrome is bone marrow transplantation. alternative treatments may include surgery to remove the spleen and other more conservative measures such as antibiotics, ivig, and avoidance of foods which may cause allergic reactions. last updated: 10/27/2010

MalaCards: Wiskott-Aldrich Syndrome, also known as wiskott aldrich syndrome, is related to thrombocytopenia and agammaglobulinemia, and has symptoms including intellectual deficit/mental/psychomotor retardation/learning disability, respiratory distress/dyspnea/respiratory failure/lung volume reduction and collapse/sudden death/cardiac arrest/cardiorespiratory arrest. An important gene associated with Wiskott-Aldrich Syndrome is WAS (Wiskott-Aldrich syndrome), and among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Immune System. The compounds tyrosine and proline have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are cellular and immune system.

Genetics Home Reference:21 Wiskott-Aldrich syndrome is characterized by abnormal immune system function (immune deficiency) and a reduced ability to form blood clots. This condition primarily affects males.

Wikipedia:64 Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema,... more...

Description from OMIM:47 301000,277970,600903,614493

Aliases & Classifications for Wiskott-Aldrich Syndrome

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Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 40NCIt, 35MeSH, 27ICD9CM, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Immune, Skin, Blood
ICD10: 26 25


Characteristics (Orphanet epidemiological data):

49
wiskott-aldrich syndrome:
Inheritance: X-linked recessive; Prevalence: 1-9/1000000; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

wiskott-aldrich syndrome 8 9 21 47 10 45 49 31 61
wiskott aldrich syndrome 43 20 22
eczema-thrombocytopenia-immunodeficiency syndrome 21 49
immunodeficiency 2 43 21
wiskott syndrome 8 21
was 43 49
eczema thrombocytopenia immunodeficiency syndrome 43
aldrich syndrome 43
imd 2 43
imd2 21


External Ids:

Disease Ontology8 DOID:9169
NCIt40 C3448
ICD9CM27 279.12
SNOMED-CT57 36070007
ICD10 via Orphanet26 D82.0
SNOMED-CT via Orphanet58 36070007
UMLS via Orphanet62 C0043194
MESH via Orphanet36 D014923
ICD1025 D82.0

Related Diseases for Wiskott-Aldrich Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Wiskott-Aldrich Syndrome family:

wiskott-aldrich syndrome 2

Diseases related to Wiskott-Aldrich Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 864)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.5WAS, SPN
2agammaglobulinemia30.3CFP, BTK
3alzheimer's disease30.3DOCK3
4shigellosis29.7WASL
5n syndrome11.2
6char syndrome10.9
7hematopoietic stem cell transplantation10.7
8protein s deficiency10.7
9micro syndrome10.7
10protein c deficiency10.6
11hyperlipidemia type 310.6
12aortic aneurysm10.6
13wiskott-aldrich syndrome 210.5
14down syndrome10.5
15thoracic aortic aneurysm10.5
16protein r deficiency10.5
17atopic dermatitis10.4
18juvenile myelomonocytic leukemia10.4
19thrombotic thrombocytopenic purpura10.4
20progressive multifocal leukoencephalopathy10.4
21adult syndrome10.4
22vasculitis10.4
23follicular lymphoma10.4
24lymphomatoid granulomatosis10.4
25primary immunodeficiency disease10.4
26null syndrome10.4
27bone fracture10.2
28neurofibromatosis10.2
29autoimmune thrombocytopenic purpura10.2
30autoimmune thyroiditis10.2
31molluscum contagiosum10.2
32klinefelter's syndrome10.2
33fanconi's anemia10.2
34vaccinia10.2
35eclampsia10.2
36juvenile xanthogranuloma10.2
37systemic lupus erythematosus10.2
38common variable immunodeficiency10.2
39acute retinal necrosis syndrome10.2
40platelet storage pool deficiency10.2
41fanconi syndrome10.2
42intussusception10.2
43ulcerative colitis10.2
44burkitt's lymphoma10.2
45kaposi's sarcoma10.2
46kawasaki disease10.2
47sclerosing cholangitis10.2
48lymphoplasmacytic lymphoma10.2
49arc syndrome10.2
50adenocarcinoma10.2

Graphical network of the top 20 diseases related to Wiskott-Aldrich Syndrome:



Diseases related to wiskott-aldrich syndrome

Clinical Features for Wiskott-Aldrich Syndrome

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Sources:
47OMIM, 49Orphanet
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Clinical features from OMIM:

301000,277970,600903,614493

Clinical synopsis from OMIM:

277970

Symptoms:

49 (show all 50)
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • encephalitis
  • early death/lethality
  • chronic/relapsing otitis
  • repeat respiratory infections
  • arthritis/synovitis/synovial proliferation
  • renal disease/nephropathy
  • asthenia/fatigue/weakness
  • fever/chilling
  • cardiac rhythm disorder/arrhythmia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • anaemia
  • chronic skin infection/ulcerations/ulcers/cancrum
  • peripheral neuropathy
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • thoracic/chest pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • urticaria
  • gingivorrhagia/gingival bleeding
  • x-linked recessive inheritance
  • microcytic anemia
  • thrombocytopenia/thrombopenia
  • hemolytic anemia
  • purpura/petichiae
  • renal glomerular defect/glomerulopathy
  • hematomas
  • chronic obstructive pulmonary disease/copd/obstructive respiratory syndrome
  • neoplasms/tumors
  • thymic aplasia/hypoplasia
  • epistaxis/nose bleeding
  • bruisability
  • platelets shape anomalies
  • inflammatory intestinal disease
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • vascularitis/vasculitides/arteritis
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • meningitis/meningeal syndrome
  • hyperostosis
  • polynuclear cells/neutrophils anomalies/neutropenia
  • platelets function anomaly
  • intracranial/cerebral/meningeal hemorrhage
  • mucosal/cutaneous hemorrhage
  • internal hemorrhage
  • lymphoma
  • myeloproliferative syndrome/chronic leukemia
  • sepsis severe/septicemia

Drugs & Therapeutics for Wiskott-Aldrich Syndrome

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Wiskott-Aldrich Syndrome

Drug clinical trials:

Search ClinicalTrials for Wiskott-Aldrich Syndrome

Search NIH Clinical Center for Wiskott-Aldrich Syndrome

Search CenterWatch for Wiskott-Aldrich Syndrome

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Wiskott-Aldrich Syndrome cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Wiskott-Aldrich Syndrome:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Hematopoietic stem cell transplantation for the treatment of genetic blood cell-related diseases
Embryonic/Adult Cultured Cells Related to Wiskott-Aldrich Syndrome:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Bone marrow-derived hematopoietic stem cells (family)
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Wiskott-Aldrich Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Wiskott-Aldrich Syndrome:

id Genetic test Affiliating Genes
1 Wiskott-aldrich Syndrome20 22 WAS

Anatomical Context for Wiskott-Aldrich Syndrome

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33MalaCards
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MalaCards organs/tissues related to Wiskott-Aldrich Syndrome:

33
Skin, Liver, Brain, Kidney, Lung, Spleen, Bone marrow, Cortex, Smooth muscle, Small intestine, Thyroid, Breast, Testis, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Wiskott-Aldrich Syndrome or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Wiskott-Aldrich Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
cellular phenotype
MP:000538411.0WASL, WAS, ARFRP1, NCKIPSD, NCK1, BTK
2
immune system phenotype
MP:000538710.9SPN, WIPF1, WASL, WAS, TFE3, DOCK3
3
hematopoietic system phenotype
MP:000539710.6WIPF1, WASL, WAS, WASF3, TFE3, TRIP10

Publications for Wiskott-Aldrich Syndrome

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51PubMed
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Articles related to Wiskott-Aldrich Syndrome:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Modelling of human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using in vivo live imaging. (23868979)
2013
2
Wiskott-Aldrich syndrome with IgA nephropathy: a case report and literature review. (22547134)
2013
3
In Wiskott-Aldrich syndrome, platelet count matters. (23449611)
2013
4
Aneurysm of ascending and descending aorta in a 10-year-old-boy with Wiskott-Aldrich syndrome. (23128546)
2013
5
Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. (22804504)
2012
6
A novel mutation of the WAS gene in a patient with Wiskott-Aldrich syndrome presenting with recalcitrant viral warts. (20863667)
2010
7
Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin. (20308062)
2010
8
The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function. (21178275)
2010
9
Results and long-term outcome in 39 patients with Wiskott-Aldrich syndrome transplanted from HLA-matched and -mismatched donors. (18846321)
2009
10
Percutaneous closure of false aneurysms of the aorta in Wiskott Aldrich syndrome. (18167364)
2008
11
Wiskott-Aldrich syndrome and molluscum contagiosum: a therapeutic challenge after reaction to cidofovir. (19126022)
2008
12
Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells. (18606666)
2008
13
Detection of 28 novel mutations in the Wiskott-Aldrich syndrome and X-linked thrombocytopenia based on multiplex PCR. (17400488)
2007
14
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. (17878299)
2007
15
The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP). (17205972)
2007
16
Recurrent V75M mutation within the Wiskott-Aldrich syndrome protein: description of a homozygous female patient. (15946311)
2005
17
Phenotypic perturbation of B cells in the Wiskott-Aldrich syndrome. (15654828)
2005
18
Intrabodies against the EVH1 domain of Wiskott-Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells. (16302976)
2005
19
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. (15494425)
2005
20
Identification of WASP mutations in 10 Australian families with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. (15203732)
2004
21
ARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators. (15485833)
2004
22
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. (12530983)
2003
23
Isolated EBV lymphoproliferative disease in a child with Wiskott-Aldrich syndrome manifesting as cutaneous lymphomatoid granulomatosis and responsive to anti-CD20 immunotherapy. (12835306)
2003
24
Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. (12727931)
2003
25
Autoimmunity in Wiskott-Aldrich syndrome. (12819473)
2003
26
The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation. (12670398)
2003
27
Flow cytometric determination of intracytoplasmic Wiskott-Aldrich syndrome protein in peripheral blood lymphocyte subpopulations. (11792389)
2002
28
Wiskott-Aldrich syndrome in a female. (12351383)
2002
29
Mixed chimera status of 12 patients with Wiskott-Aldrich syndrome (WAS) after hematopoietic stem cell transplantation: evaluation by flow cytometric analysis of intracellular WAS protein expression. (12149199)
2002
30
The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae. (11901111)
2002
31
Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex. (11179351)
2001
32
Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. (10995437)
2000
33
Unrelated partially matched peripheral blood stem cell transplantation with highly purified CD34+ cells in a child with Wiskott-Aldrich syndrome. (10918439)
2000
34
Wiskott Aldrich syndrome presenting as congenital thrombocytopenia. (10671992)
1999
35
Allogeneic peripheral blood stem cell transplantation in a Wiskott-Aldrich syndrome patient. (10467341)
1999
36
Systemic vasculitis and aneurysm formation in the Wiskott-Aldrich syndrome. (10560364)
1999
37
Long-term survival following non-Hodgkin's lymphoma arising in Wiskott-Aldrich syndrome. (10473730)
1999
38
Wiskott-Aldrich syndrome protein, WASP. (10224664)
1999
39
Unique and recurrent WAS gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. (10575547)
1999
40
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation. (9660763)
1998
41
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. (9889097)
1998
42
Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation. (9207440)
1997
43
Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. (9307968)
1997
44
Unusual MRI and pathologic findings of progressive multifocal leukoencephalopathy complicating adult Wiskott-Aldrich syndrome. (9008537)
1997
45
Wiskott-Aldrich syndrome in two sisters. (9129730)
1997
46
Characterization of a deletion mutation involving exons 3-7 of the WASP gene detected in a patient with Wiskott-Aldrich syndrome. (9338585)
1997
47
WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. (8528199)
1995
48
Peripheral expansion of V delta 1-J delta 1/J delta 2+ gamma delta T cells and large granular lymphocytes in a patient with Wiskott-Aldrich syndrome. (7645397)
1995
49
Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. (8069912)
1994
50
Defective expression of CD23 and autocrine growth-stimulation in Epstein-Barr virus (EBV)-transformed B cells from patients with Wiskott-Aldrich syndrome (WAS). (8380367)
1993

Genetic Variations for Wiskott-Aldrich Syndrome

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63UniProtKB/Swiss-Prot
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Genetic disease variations for Wiskott-Aldrich Syndrome:

63 (show all 19)
id Symbol AA change Variation SNP ID
1WASp.Glu31LysVAR_005825
2WASp.Ser82ProVAR_005829
3WASp.Arg86HisVAR_005830
4WASp.Arg86LeuVAR_005831
5WASp.Arg86CysVAR_005832
6WASp.Trp97CysVAR_005833
7WASp.Glu131LysVAR_005834rs146220228
8WASp.Glu133LysVAR_005835
9WASp.Gly187CysVAR_005836
10WASp.Lys476GluVAR_005838
11WASp.Cys43TrpVAR_008105
12WASp.Thr45MetVAR_008106
13WASp.Cys73ArgVAR_008107
14WASp.Phe84LeuVAR_008109
15WASp.Gly89AspVAR_008110
16WASp.Gln52HisVAR_012710
17WASp.Gly70TrpVAR_012711
18WASp.Pro58LeuVAR_022806
19WASp.Ala134ThrVAR_022807

Expression for genes affiliated with Wiskott-Aldrich Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wiskott-Aldrich Syndrome

Search GEO for disease gene expression data for Wiskott-Aldrich Syndrome.

Pathways for genes affiliated with Wiskott-Aldrich Syndrome

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Sources:
54Reactome, 4Cell Signaling Technology, 12EMD Millipore, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database
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Pathways related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Fcgamma receptor (FCGR) dependent phagocytosis54
Hide members
11.0CDC42, WIPF1, WASF1, WASL, WASF2, WAS
2
Immune System54
Hide members
11.0WIPF1, WASF1, WASL, WASF2, WAS, WASF3
3
Cytoskeletal Signaling4
10.8WASL, WASF2, WAS, WASF3, NCK1, CDC42
4
Cytoskeleton remodeling CDC42 in cellular processes
Hide members
10.8WASF1, WASL, WASF2, WAS, NCK1, CDC42
5
Fc gamma R-mediated phagocytosis30
10.8WASF1, WASL, WASF2, WAS, WASF3, CDC42
6
Adherens junction30
10.8WASF1, WASL, WASF2, WAS, WASF3, CDC42
7
PKC-Theta Pathway52
Hide members
10.8WASL, WAS, NCK1, BTK, CDC42, ACTR2
8
PAK Pathway52
Hide members
10.8WASF1, WASL, WAS, BTK, CDC42, ACTR2
9
Actin Nucleation by ARP-WASP Complex52
Hide members
10.8WASF1, WASL, WAS, NCK1, CDC42, ACTR2
10
Rho Family GTPases52
Hide members
10.8WASF1, WASL, WASF3, BTK, CDC42, ACTR2
11
Immune response Fc epsilon RI pathway12
Hide members
10.7WIPF1, WAS, BTK, CDC42, ACTR2
12
Bacterial invasion of epithelial cells30
10.7WASF1, WASL, WASF2, WAS, CDC42
13
Shigellosis30
10.7WASF1, WASL, WASF2, WAS, CDC42
14
Regulation of Actin Cytoskeleton38
Hide members
10.7WASF1, WASL, WASF2, WAS, CDC42
15
Salmonella infection30
10.7WASF1, WASL, WASF2, WAS, CDC42
16
Development Slit-Robo signaling
Hide members
10.7ACTR2, CDC42, NCK1, WAS, WASL
17
Integrin Pathway52
Hide members
10.7WASF1, WAS, BTK, CDC42, ACTR2
18
Cell adhesion Integrin-mediated cell adhesion and migration
Hide members
10.7WASF1, WASL, WAS, CDC42, ACTR2
19
CDC42 signaling events38
Hide members
10.7WASF1, WASL, WASF2, CDC42, ACTR2
20
B cell receptor signaling pathway30
Hide members
10.7CDC42, BTK, NCK1, WAS
21
B Cell Receptor Signaling Pathway38
10.7ACTR2, BTK, NCK1, WAS
22
Salmonella Infection52
10.7ACTR2, CDC42, WAS, WASF1
23
fMLP Pathway52
Hide members
10.7ACTR2, CDC42, WAS, WASF1
24
Guidance Cues and Growth Cone Motility52
10.7WASL, NCK1, CDC42, ACTR2
25
ErbB1 downstream signaling38
10.7ACTR2, CDC42, WASF2, WASL
26
TCR signaling in naive CD4+ T cells38
10.6WAS, NCK1, CDC42
27
G13 Signaling Pathway38
10.6WASL, WAS, CDC42
28
BDNF signaling pathway38
10.6DOCK3, NCK1, CDC42
29
Cytoskeleton remodeling Reverse signaling by ephrin B
Hide members
10.6ACTR2, WASL, WIPF1
30
Cell adhesion Ephrins signaling
Hide members
10.6CDC42, NCK1, WASL
31
ICos-ICosL Pathway in T-Helper Cell52
Hide members
10.6WAS, CDC42, ACTR2
32
Signaling by Slit52
10.6WASL, CDC42, ACTR2
33
Cell adhesion Cadherin-mediated cell adhesion12
10.6WASL, CDC42, ACTR2
34
Nephrin interactions54
10.6NCK1, WASL
35
Nephrin/Neph1 signaling in the kidney podocyte38
10.6NCK1, WASL
36
Cytoskeleton remodeling Role of PDGFs in cell migration
Hide members
10.6CDC42, WASL

Compounds for genes affiliated with Wiskott-Aldrich Syndrome

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45Novoseek, 60Tocris Bioscience
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Compounds related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4511.1WASL, WASF2, WAS, SNX9, NCK1, TRIP10
2proline4510.9WIPF1, WASL, WAS, TFE3, NCK1, BTK
3pip24510.9CDC42, BTK, NCK1, WAS, WASL
4wiskostatin4510.8WASL, WAS, CDC42
5phosphatidylinositol4510.7WAS, NCK1, BTK, CDC42, WASL
6latex4510.7WASL, WAS, CDC42
7phosphoinositide4510.6WASL, NCK1, BTK, CDC42
8jasplakinolide45 6011.6CDC42, WASL
9cytochalasin d45 6011.3CDC42, WAS, WASL

GO Terms for genes affiliated with Wiskott-Aldrich Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582911.1WIPF1, WASL, WASF2, WAS, NCKIPSD, NCK1
2actin cytoskeletonGO:01562910.9ACTR2, WIPF1, WASF1, WASL, WASF2, WAS
3actin capGO:03047810.6ACTR2, WASL
4ruffleGO:00172610.6WIPF1, WASF2, SNX9
5lamellipodiumGO:03002710.6WASF3, WASF2, WASL
6vesicle membraneGO:01250610.5NCK1, WAS
7cytoplasmic membrane-bounded vesicleGO:01602310.3SNX9, WASL, WIPF1

Biological processes related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508711.3WIPF1, WASL, WASF2, WAS, NCKIPSD, NCK1
2Fc-gamma receptor signaling pathway involved in phagocytosisGO:03809611.2ACTR2, WIPF1, WASL, WASF2, WAS, NCKIPSD
3protein complex assemblyGO:00646111.0WIPF1, WASF1, WASL, WAS, WASF3
4actin polymerization or depolymerizationGO:00815410.9WAS, WASL, WIPF1
5actin filament-based movementGO:03004810.8WIPF1, WASF2, WAS
6actin filament polymerizationGO:03004110.8WASF3, WAS, WASF1
7establishment or maintenance of cell polarityGO:00716310.8CDC42, ACTR2, SPN
8lamellipodium assemblyGO:03003210.8NCK1, WASF3, WASF2
9spindle localizationGO:05165310.6ACTR2, WASL
10actin cytoskeleton organizationGO:03003610.6CDC42, TRIP10, WASF2
11response to other organismGO:05170710.6WIPF1, NCK1
12cellular component movementGO:00692810.5ACTR2, WASL, WASF1
13small GTPase mediated signal transductionGO:00726410.4ARFRP1, DOCK3, TRIP10, CDC42

Molecular functions related to Wiskott-Aldrich Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.2WASF1, WASL, WASF2, WAS, ARFRP1, DOCK3
2actin bindingGO:00377910.6ACTR2, WIPF1, WASF1, WASL, WASF2, WAS

Products for genes affiliated with Wiskott-Aldrich Syndrome

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  • Antibodies
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Sources for Wiskott-Aldrich Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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