MCID: WLF001
MIFTS: 60

Wolff-Parkinson-White Syndrome malady

Cardiovascular, Genetic categories

Summaries for Wolff-Parkinson-White Syndrome

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards: Wolff-Parkinson-White Syndrome, also known as wolff parkinson white syndrome, is related to hypertrophic cardiomyopathy and familial hypertrophic cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and AMPK inhibits chREBP transcriptional activation activity. The drugs adenosine and adenosine monophosphate and the compounds metformin hydrochloride and pt 1 have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and thyroid.

Genetics Home Reference:21 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:64 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the... more...

Description from OMIM:47 194200

Aliases & Classifications for Wolff-Parkinson-White Syndrome

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 22GTR, 20GeneTests, 40NCIt, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Cardiovascular


Aliases & Descriptions:

wolff-parkinson-white syndrome 8 9 43 21 47 10 45 61
wolff parkinson white syndrome 8 20
wolff-parkinson-white pattern 8 22
auriculoventricular accessory pathway syndrome 43
ventricular familial preexcitation syndrome 43
ventricular pre-excitation with arrhythmia 21
anomalous ventricular excitation syndrome 43
false bundle branch block syndrome 43
parkinson disease, late-onset 61
pre-excitation syndromes 61
wolff-park-white syndr. 8
preexcitation syndrome 43
wpw syndrome 21


External Ids:

Disease Ontology8 DOID:384
OMIM47 194200
NCIt40 C35132
MeSH35 D014927
ICD1025 I45.6

Related Diseases for Wolff-Parkinson-White Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic cardiomyopathy31.0MYH7, PRKAG2
2familial hypertrophic cardiomyopathy30.6MYH7
3n syndrome11.1
4char syndrome10.8
5ebstein anomaly10.7
6parkinson's disease10.7
7bod syndrome10.7
8conn's syndrome10.7
9brugada syndrome10.7
10anomalous atrioventricular excitation10.7
11short syndrome10.6
12young syndrome10.6
13image syndrome10.6
14syncope10.6
15tuberous sclerosis10.5
16acute myocardial infarction10.5
17atrioventricular block10.4
18dextrocardia10.4
19adult syndrome10.4
20inferior myocardial infarction10.4
21tricuspid atresia10.4
22superior vena cava syndrome10.4
23familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related10.4
24mitochondrial cardiomyopathy10.4
25parkinson disease, late-onset10.3
26sotos syndrome10.3
27lown-ganong-levine syndrome10.3
28leopard syndrome10.3
29marfan syndrome10.3
30ankylosing spondylitis10.3
31lutembacher's syndrome10.3
32coronary aneurysm10.3
33danon disease10.3
34placenta accreta10.3
35melas syndrome10.3
36alagille syndrome10.3
37becker muscular dystrophy10.3
38duchenne muscular dystrophy10.3
39gestational diabetes10.3
40peripartum cardiomyopathy10.3
41familial atrial fibrillation10.3
42scimitar syndrome10.3
43leber hereditary optic neuropathy10.3
44cocaine abuse10.3
45subacute bacterial endocarditis10.3
46hypokalemic periodic paralysis10.3
47adenoma10.3
48asthma10.3
49spondylitis10.3
50systemic scleroderma10.3

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Clinical Features for Wolff-Parkinson-White Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

194200

Clinical synopsis from OMIM:

194200

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Wolff-Parkinson-White Syndrome

Drug clinical trials:

Search ClinicalTrials for Wolff-Parkinson-White Syndrome

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Search CenterWatch for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Wolff-Parkinson-White Syndrome

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-parkinson-white Syndrome20 PRKAG2
2 Wolff-parkinson-white Pattern22

Anatomical Context for Wolff-Parkinson-White Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

33
Spinal cord, Heart, Thyroid, Uterus, Placenta, Atrioventricular node, Fetal thyroid

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Wolff-Parkinson-White Syndrome

Sources:
51PubMed
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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Noninvasive localization of accessory pathways in patients with wolff-Parkinson-white syndrome: a strain imaging study. (23967027)
2013
2
Bundle branch block after ablation for Wolff-Parkinson-White syndrome. (23073281)
2013
3
Usefulness of severe cardiac sympathetic dysfunction to predict the occurrence of rapid atrial fibrillation in patients with Wolff-Parkinson-White syndrome. (23711805)
2013
4
Computed tomography of a coronary sinus diverticulum associated with Wolff-Parkinson-White syndrome. (21699845)
2012
5
Rapid recovery from congestive heart failure following successful radiofrequency catheter ablation in a patient with late onset of Wolff-Parkinson-White syndrome. (22293802)
2012
6
A novel technique for zero-fluoroscopy catheter ablation used to manage Wolff-Parkinson-White syndrome with a left-sided accessory pathway. (22367551)
2012
7
Risk of sudden death in Wolff-Parkinson-White syndrome: how high is the risk? (22215858)
2012
8
Anaesthetic management of Wolff-Parkinson-White syndrome for hysterectomy. (22013255)
2011
9
Global and regional left ventricular contractile impairment in patients with wolff-Parkinson-white syndrome. (19652729)
2009
10
Predictors of the atrial fibrillation occurrence in patients with Wolff-Parkinson-White syndrome. (19838953)
2009
11
Precipitation of ventricular fibrillation by intravenous diltiazem and metoprolol in a young patient with occult Wolff-Parkinson-White syndrome. (18507555)
2008
12
Occurrence of intermittent Wolff-Parkinson-White syndrome during intravenous sedation. (18410873)
2008
13
Ebstein's anomaly, Wolff-Parkinson-White syndrome and rheumatic mitral stenosis: role for combined electrophysiological and surgical management. (17453084)
2007
14
Surgical treatment of Wolff-Parkinson-White syndrome: a timeless procedure? (17536612)
2007
15
Multiple tachycardia forms occurring in a patient with Wolff-Parkinson-White syndrome and acute myocardial infarction. (17534262)
2007
16
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? (16686673)
2006
17
Electrophysiologic characteristics and radiofrequency catheter ablation in children with Wolff-Parkinson-White syndrome. (16689844)
2006
18
Wolff-Parkinson-White syndrome mimicking acute inferolateral myocardial ischaemia in pneumonia. (16377057)
2006
19
Is exercise stress testing a cost-saving strategy for risk assessment of pediatric wolff-Parkinson-white syndrome patients? (21845141)
2006
20
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. (16339829)
2006
21
The mechanism of sudden death in the Wolff-Parkinson-White syndrome. (16403081)
2005
22
Should catheter ablation be performed in asymptomatic patients with Wolff-Parkinson-White syndrome? Catheter ablation should be performed in asymptomatic patients with Wolff-Parkinson-White syndrome. (16208793)
2005
23
Complete heart block after mediastinal irradiation in a patient with the Wolff-Parkinson-White syndrome. (16137521)
2005
24
Mitochondrial hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome. (15340680)
2004
25
The different electrophysiological characteristics in children with Wolff-Parkinson-White syndrome between those with and without atrial fibrillation. (14764177)
2004
26
Multiple accessory pathways in pediatric patients with Wolff-Parkinson-White syndrome. (12745099)
2003
27
Use of electrophysiologic testing to assess risk in children with Wolff-Parkinson-White syndrome. (12365171)
2002
28
Non-invasive diagnosis of concealed Wolff-Parkinson-White syndrome by detection of concealed anterograde pre-excitation. (11348037)
2001
29
Gender and atrioventricular conduction properties of patients with symptomatic atrioventricular nodal reentrant tachycardia and Wolff-Parkinson-White syndrome. (11590556)
2001
30
Activation-recovery intervals of 12-lead electrocardiograms before and after catheter ablation in patients with Wolff-Parkinson-White syndrome. (11316126)
2001
31
Iatrogenically induced intractable atrioventricular reentrant tachycardia after verapamil and catheter ablation in a patient with Wolff-Parkinson-White syndrome and idiopathic dilated cardiomyopathy. (9249847)
1997
32
Quantitative analysis of concealed conduction into accessory atrioventricular pathways in Wolff-Parkinson-White syndrome. (9170136)
1997
33
Body surface potential mapping of a patient with Wolff-Parkinson-White syndrome with two accessory pathways and two atrial pacemaker complexes. (8728600)
1996
34
Atrial Septal Aneurysm and Dilated Sinus of Valsalva in a Patient with Wolff-Parkinson-White Syndrome. (11442909)
1996
35
The antiarrhythmic effect of verapamil on atrioventricular re-entry in the Wolff-Parkinson-White syndrome: a computer model study. (8803672)
1996
36
Sudden Death During Flecainide Therapy for Atrial Fibrillation Complicating Wolff-Parkinson-White Syndrome. (10684413)
1996
37
Surgical treatment of patients with Wolff-Parkinson-White syndrome and associated Ebstein's anomaly. (8523883)
1995
38
Proarrhythmia in patients with the Wolff-Parkinson-White syndrome after standard doses of intravenous adenosine. (7847646)
1995
39
Radiofrequency catheter ablation used to unmask infarction Q waves in Wolff-Parkinson-White syndrome. (7942468)
1994
40
Electrocardiographic case. Irregular broad complex tachycardia. Wolff-Parkinson-White syndrome with atrial flutter-fibrillation. (7761893)
1994
41
Surgical ablation of Wolff-Parkinson-White syndrome in children and young adults. (8176779)
1994
42
Gated blood pool SPECT and phase analysis to assess simulated Wolff-Parkinson-White syndrome in the baboon. (8233841)
1993
43
Association of a Wolff-Parkinson-White syndrome and a fistula from the coronary to the pulmonary artery. (8447186)
1993
44
Wolff-Parkinson-White syndrome and the use of radiofrequency catheter ablation. (8420852)
1993
45
Atrioventricular junctional and orthodromic atrioventricular reentrant tachycardia in Wolff-Parkinson-White syndrome. (8433058)
1993
46
Non-invasive three-dimensional localisation of arrhythmogenic foci in Wolff-Parkinson-White syndrome and in ventricular tachycardia by radionuclide ventriculography: phase analysis of double-angulated integrated single photon emission computed tomography (SPECT). (8461217)
1993
47
Nursing grand rounds: Wolff-Parkinson-White syndrome: a challenging case study. (8389818)
1993
48
Atrial fibrillation in the Wolff-Parkinson-White syndrome. (1509997)
1992
49
Arrival of excitation at right ventricular apical endocardium in Wolff-Parkinson-White syndrome type A, with and without right bundle-branch block. (4712463)
1973
50
Modification of the electrocardiogram of myocardial infarction by anomalous atrioventricular excitation; Wolff-Parkinson-White syndrome. (18123053)
1949

Genetic Variations for Wolff-Parkinson-White Syndrome

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Wolff-Parkinson-White Syndrome:

63
id Symbol AA change Variation SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 4Cell Signaling Technology, 50PharmGKB, 12EMD Millipore, 60Tocris Bioscience
See all sources

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.9PRKAA2, PRKAG2
39.6NKX2-5, BMP2
49.6PRKAA1, PRKAA2
5
Hide members
9.5PRKAG2, PRKAA2, PRKAG3
6
Hide members
9.2MYH7, NKX2-5, BMP2
79.2MYH7, NKX2-5, BMP2
89.0BMP2, PRKAA2, PRKAA1
98.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
10
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
11
Translation Insulin regulation of translation
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
128.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
13
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
148.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
15
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
168.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
17
Development Leptin signaling via PI3K-dependent pathway
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
188.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
198.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
208.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
21
Hide members
8.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2
22
Hide members
8.3BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1
23
Hide members
8.0AP2A2, MT-ND5, PRKAG2, PRKAA2, PRKAG3, PRKAA1
24
Hide members
7.9BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1, MYH7
25
Hide members
7.4AP2A2, BMP2, JAG1, PRKAG2, PRKAA2, PRKAG3

Compounds for genes affiliated with Wolff-Parkinson-White Syndrome

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1metformin hydrochloride609.8PRKAA2, PRKAA1
2pt 1609.8PRKAA2, PRKAA1
3a 769662609.8PRKAA2, PRKAA1
4dorsomorphin dihydrochloride609.8PRKAA2, PRKAA1
5phenformin45 1110.7PRKAA1, PRKAA2
6acadesine459.6PRKAA2, PRKAA1
7phosphocreatine45 2410.4MYH7, PRKAA1, PRKAA2
8aicar45 11 2411.3PRKAA2, PRKAA1
9rapamycin459.0PRKAA1, PRKAA2, BMP2
10nitric oxide45 11 2410.5BMP2, JAG1, PRKAA2, PRKAA1, NKX2-5
11creatinine458.5MYH7, PRKAA1, PRKAA2, BMP2
12threonine458.4BMP2, MT-ND5, PRKAA2, PRKAA1, MYH7
13serine458.0MYH7, NKX2-5, PRKAA1, PRKAA2, MT-ND5, BMP2

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315889.2PRKAA1, PRKAG3, PRKAG2

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:04230410.2PRKAG2, PRKAA2
2carnitine shuttleGO:00685310.1PRKAG2, PRKAA2
3regulation of energy homeostasisGO:20005059.9PRKAA1, PRKAA2
4regulation of circadian rhythmGO:0427529.8PRKAA1, PRKAA2
5fatty acid homeostasisGO:0550899.8PRKAA2, PRKAA1
6cardiac muscle tissue morphogenesisGO:0550089.8BMP2, NKX2-5
7cellular response to nutrient levelsGO:0316699.8PRKAA2, PRKAA1
8adult heart developmentGO:0075129.8NKX2-5, MYH7
9positive regulation of glycolysisGO:0458219.8PRKAA1, PRKAA2
10lipid biosynthetic processGO:0086109.7PRKAA2, PRKAA1
11cellular response to glucose starvationGO:0421499.7PRKAA1, PRKAA2
12rhythmic processGO:0485119.6PRKAA1, PRKAA2
13positive regulation of autophagyGO:0105089.6PRKAA1, PRKAA2
14cholesterol biosynthetic processGO:0066959.6PRKAA1, PRKAA2
15negative regulation of TOR signaling cascadeGO:0320079.5PRKAA2, PRKAA1
16cardiac muscle cell differentiationGO:0550079.3NKX2-5, BMP2
17fatty acid biosynthetic processGO:0066339.2PRKAA1, PRKAG3, PRKAA2, PRKAG2
18cell cycle arrestGO:0070509.2PRKAG2, PRKAA2, PRKAG3, PRKAA1
19insulin receptor signaling pathwayGO:0082869.2PRKAG2, PRKAA2, PRKAG3, PRKAA1

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityGO:0473229.6PRKAA1, PRKAA2
2[acetyl-CoA carboxylase] kinase activityGO:0504059.5PRKAA1, PRKAA2
3histone serine kinase activityGO:0351749.3PRKAA2, PRKAA1
4AMP-activated protein kinase activityGO:0046799.2PRKAA1, PRKAG3, PRKAA2
5ATP bindingGO:0055248.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2

Products for genes affiliated with Wolff-Parkinson-White Syndrome

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Sources for Wolff-Parkinson-White Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet