WPWS
MCID: WLF001
MIFTS: 56

Wolff-Parkinson-White Syndrome (WPWS) malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 52 11 48 24 25 70 27 12 50 39 13 68
Preexcitation Syndrome 48 24 68
Ventricular Familial Preexcitation Syndrome 48 70
Anomalous Atrioventricular Excitation 11 68
Wolff-Parkinson-White Pattern 11 27
Wpw Syndrome 48 25
Auriculoventricular Accessory Pathway Syndrome 48
 
Ventricular Pre-Excitation with Arrhythmia 25
Anomalous Ventricular Excitation Syndrome 48
False Bundle Branch Block Syndrome 48
Ventricular Preexcitation 68
Anomalous a-V Excitation 11
Wpws 70

Classifications:



External Ids:

OMIM52 194200
Disease Ontology11 DOID:384
ICD1030 I45.6
ICD9CM32 426.7
MeSH39 D014927
NCIt45 C35132

Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:48 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related and cardiomyopathy, hypertrophic 6, and has symptoms including stroke, cardiomyopathy and sudden cardiac death. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and Longevity regulating pathway. The drugs adenosine phosphate sodium and adenosine triphosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid.

Genetics Home Reference:25 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot:70 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia:71 Wolff–Parkinson–White syndrome (WPW) is a disorder due to a specific type of problem with the... more...

Description from OMIM:52 194200

Related Diseases for Wolff-Parkinson-White Syndrome

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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related12.3
2cardiomyopathy, hypertrophic 611.3
3atrial fibrillation10.9
4myoclonic epilepsy associated with ragged-red fibers10.9
5cardiomyopathy10.6
6myocardial infarction10.6
7dilated cardiomyopathy10.4
8brugada syndrome10.4
9right bundle branch block10.3
10tuberous sclerosis10.3
11syncope10.3
12tricuspid atresia10.1
13acute myocardial infarction10.1
14congestive heart failure10.1
15cardiac arrest10.1
16thyroiditis10.1
17myocarditis10.1
18dextrocardia10.1
19muscular dystrophy10.1
20transposition of the great arteries10.1
21sudden cardiac death10.1
22aneurysm10.1
23rasa1-related disorders10.1PRKAA2, PRKAG2
24schizophrenia10.0
25asthma10.0
26leigh syndrome10.0
27danon disease10.0
28alagille syndrome10.0
29duchenne muscular dystrophy10.0
30becker muscular dystrophy10.0
31pulmonary atresia with intact ventricular septum10.0
32hemolytic anemia10.0
33spinal cord injury10.0
34familial atrial fibrillation10.0
35endocarditis10.0
36heart disease10.0
37gestational diabetes10.0
38cardiac sarcoidosis10.0
39leopard syndrome10.0
40epilepsy10.0
41hypogonadism10.0
42lutembacher's syndrome10.0
43myotonia congenita10.0
44cervicitis10.0
45ischemia10.0
46cerebritis10.0
47lactic acidosis10.0
48subacute bacterial endocarditis10.0
49placenta accreta10.0
50pneumonia10.0

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Ischemic Heart DiseaseFamilial Atrial Fibrillation
Heart DiseaseMitral Valve Disease
Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

 64 (show all 10)
id Description HPO Frequency HPO Source Accession
1 stroke64 HP:0001297
2 cardiomyopathy64 HP:0001638
3 sudden cardiac death64 HP:0001645
4 wolff-parkinson-white syndrome64 HP:0001716
5 palpitations64 HP:0001962
6 paroxysmal atrial fibrillation64 HP:0004757
7 paroxysmal supraventricular tachycardia64 HP:0004763
8 shortened pr interval64 HP:0005165
9 prolonged qrs complex64 HP:0006677
10 ventricular preexcitation with multiple accessory pathways64 HP:0006684

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECGCompletedNCT00251121
2Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory DuctTerminatedNCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern27
2 Wolff-Parkinson-White Syndrome27 24 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

36
Heart, Testes, Thyroid, Spinal cord, Atrioventricular node, Placenta, Uterus

Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. (28084962)
2017
2
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. (28491758)
2017
3
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. (27815796)
2017
4
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. (28214246)
2017
5
Tachyarrhythmia in Wolff-Parkinson-White Syndrome. (27429700)
2016
6
The Wolff-Parkinson-White Syndrome: A Test Bed for the Assessment of Myocardial Dyssynchrony? (27307557)
2016
7
Spontaneous Transition of Double Tachycardias with Atrial Fusion in a Patient with Wolff-Parkinson-White Syndrome. (27482269)
2016
8
Noninvasive Localization of Accessory Pathways in Wolff-Parkinson-White Syndrome by Three-Dimensional Speckle Tracking Echocardiography. (27307551)
2016
9
PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population. (27866917)
2016
10
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. (27555124)
2016
11
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. (26719390)
2016
12
Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff-Parkinson-White syndrome: Uneven depression of accessory pathway conduction. (28491747)
2016
13
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. (27042562)
2016
14
Physiological Expression of AMPKI^2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice. (27621313)
2016
15
Wolff-Parkinson-White Syndrome in a Term Infant Presenting With Cardiopulmonary Arrest. (26742096)
2016
16
The impact of B-type natriuretic peptide levels on the suppression of accompanying atrial fibrillation in Wolff-Parkinson-White syndrome patients after accessory pathway ablation. (26917195)
2016
17
Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading. (27869041)
2016
18
Detecting Regional Myocardial Abnormalities in Patients With Wolff-Parkinson-White Syndrome With the Use of ECG-Gated Cardiac MDCT. (26866341)
2016
19
Depression masquerading as chest pain in a patient with Wolff Parkinson White syndrome. (27738505)
2016
20
Wolff-Parkinson-White syndrome with bundle branch and fascicular block: The diagnostic clue of electrocardiogram. (25497533)
2015
21
Atrial fibrillation with Wolff-Parkinson-White syndrome in epilepsy: A potentially fatal combination. (26552553)
2015
22
Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation. (26480930)
2015
23
Atrial Fibrillation in a 35-Year-Old Man with Wolff-Parkinson-White Syndrome. (26504453)
2015
24
A young patient with atypical type-B Wolff-Parkinson-White syndrome accompanied by left ventricular dysfunction. (26336525)
2015
25
Treatment of Wolff-Parkinson-White Syndrome With a Thoracoscopic Surgical Procedure. (26140800)
2015
26
Utility of Exercise Testing and Adenosine Response for Risk Assessment in Children with Wolff-Parkinson-White Syndrome. (26010236)
2015
27
Variable primary phenotypic manifestations in a rare familial form of Wolff-Parkinson-White syndrome and hypertrophic cardiomyopathy. (26333379)
2015
28
Response to letter regarding article, "Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients". (25986452)
2015
29
Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. (26284702)
2015
30
Extracorporeal life support for cardiac arrest in a 13-year-old girl caused by Wolff-Parkinson-White syndrome. (26314214)
2015
31
Wolff-Parkinson-White syndrome: comprehensive electrophysiologic assessment with the help of a single PVC. (26120612)
2015
32
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. (26256551)
2015
33
Comparison of the accuracy of three algorithms in predicting accessory pathways among adult Wolff-Parkinson-White syndrome patients. (26384677)
2015
34
Supraventricular Tachycardia Cardioverted by an Automated External Debrillator in a 9-year-old Male with a History of Wolff-Parkinson-White Syndrome. (25664915)
2015
35
MY APPROACH to Wolff-Parkinson-White syndrome. (25592237)
2015
36
Swallowing-induced atrial tachyarrhythmias successfully ablated at the left posterior interatrial septum in patient with wolff-Parkinson-white syndrome. (26023316)
2015
37
50th anniversary landmark commentary on Sealy WC, Hattler BG Jr, Blumenschein SD, Cobb FR. Surgical treatment of Wolff-Parkinson-White syndrome. Ann Thorac Surg 1969;8:1-11. (25742810)
2015
38
Thyroid storm in a patient with Wolff-Parkinson-White syndrome. (26670895)
2015
39
Accessory conduction pathway ablated by myocarditis in a patient with Wolff-Parkinson-White syndrome. (26520696)
2015
40
Letter by Fenici et al Regarding Articles, "Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation: Insights From a Registry Study of 2169 Patients" and "The Asymptomatic Wolff-Parkinson-White Patient: Time to be More Proactive?". (25986451)
2015
41
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. (26361569)
2015
42
Epidemiological profile of Wolff-Parkinson-White syndrome in a general population younger than 50 years of age in an era of radiofrequency catheter ablation. (24798784)
2014
43
Wolff-Parkinson-White Syndrome in Congenital Rubella Syndrome. (24567174)
2014
44
Wolff-Parkinson-White syndrome unmasked by atrial pacing in a patient with cardiac sarcoidosis. (24696224)
2014
45
Marked septal dyskinesis from Wolff-Parkinson-White syndrome. (25446063)
2014
46
Exercise testing in children with Wolff-Parkinson-White syndrome: what is its value? (24728424)
2014
47
Wolff-Parkinson-White syndrome (WPW) and athletes: Darwin at play? (25722079)
2014
48
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. (25269932)
2014
49
Tachydysrhythmia treatment and adverse events in patients with wolff-Parkinson-white syndrome. (24880554)
2014
50
Recurrence of accessory pathway after radiofrequency ablation from a benign to a malignant form of Wolff-Parkinson-White syndrome: a very uncommon case. (24692515)
2014

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

70
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264rs121908987
2PRKAG2p.Arg531GlyVAR_032909rs121908990

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRKAG2NM_ 016203.3(PRKAG2): c.905G> A (p.Arg302Gln)SNVPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.8PRKAA2, PRKAG2
2
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
3
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
4
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
5
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
6
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
79.3PRKAA2, PRKAG2, PRKAG3
8
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
9
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
10
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
11
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
12
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
139.3PRKAA2, PRKAG2, PRKAG3
149.3PRKAA2, PRKAG2, PRKAG3
159.3PRKAA2, PRKAG2, PRKAG3
169.3PRKAA2, PRKAG2, PRKAG3
17
Show member pathways
9.3PRKAA2, PRKAG2, PRKAG3
189.3PRKAA2, PRKAG2, PRKAG3
199.3PRKAA2, PRKAG2, PRKAG3
209.0BMP2, NKX2-5
218.9JAG1, PRKAA2, PRKAG2, PRKAG3
228.8MYH7, PRKAA2, PRKAG2, PRKAG3
23
Show member pathways
8.8MYH7, PRKAA2, PRKAG2, PRKAG3
24
Show member pathways
8.8MYH7, PRKAA2, PRKAG2, PRKAG3
258.8CBS, PRKAA2, PRKAG2, PRKAG3
268.6BMP2, MYH7, NKX2-5
27
Show member pathways
8.6BMP2, MYH7, NKX2-5

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleotide-activated protein kinase complexGO:00315889.3PRKAA2, PRKAG2, PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1carnitine shuttleGO:000685310.5PRKAA2, PRKAG2
2regulation of fatty acid biosynthetic processGO:004230410.4PRKAA2, PRKAG2
3inner ear developmentGO:004883910.1BMP2, JAG1
4positive regulation of osteoblast differentiationGO:004566910.1BMP2, JAG1
5cell cycle arrestGO:000705010.0PRKAA2, PRKAG2, PRKAG3
6fatty acid biosynthetic processGO:000663310.0PRKAA2, PRKAG2, PRKAG3
7fatty acid metabolic processGO:000663110.0PRKAA2, PRKAG2, PRKAG3
8macroautophagyGO:001623610.0PRKAA2, PRKAG2, PRKAG3
9adult heart developmentGO:00075129.9MYH7, NKX2-5
10cardiac muscle contractionGO:00600489.9MYH7, NKX2-5
11regulation of macroautophagyGO:00162419.9PRKAA2, PRKAG2, PRKAG3
12sterol biosynthetic processGO:00161269.8PRKAA2, PRKAG2
13cardiac muscle cell differentiationGO:00550079.8BMP2, NKX2-5
14cardiac muscle tissue morphogenesisGO:00550089.8BMP2, NKX2-5
15regulation of signal transduction by p53 class mediatorGO:19017969.7PRKAA2, PRKAG2, PRKAG3
16protein phosphorylationGO:00064689.3BMP2, PRKAA2, PRKAG2, PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase activityGO:00046799.3PRKAA2, PRKAG2, PRKAG3

Sources for Wolff-Parkinson-White Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet