MCID: WLF001
MIFTS: 59

Wolff-Parkinson-White Syndrome malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 49 10 11 45 22 23 47 12 67 36 65
Preexcitation Syndrome 45 22 65
Ventricular Familial Preexcitation Syndrome 45 67
Anomalous Atrioventricular Excitation 10 65
Wolff-Parkinson-White Pattern 10 24
Wpw Syndrome 45 23
Auriculoventricular Accessory Pathway Syndrome 45
 
Ventricular Pre-Excitation with Arrhythmia 23
Anomalous Ventricular Excitation Syndrome 45
False Bundle Branch Block Syndrome 45
Ventricular Preexcitation 65
Anomalous a-V Excitation 10
Wpws 67

Classifications:



External Ids:

OMIM49 194200
Disease Ontology10 DOID:384
ICD1027 I45.6
ICD9CM29 426.7
MeSH36 D014927
NCIt42 C35132
UMLS65 C0043202, C0392470, C0032915 C0559106, more

Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:45 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to cardiomyopathy, hypertrophic 6 and familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related, and has symptoms including arrhythmia, ventricular preexcitation with multiple accessory pathways and prolonged qrs complex. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and Heart Development. The drugs adenosine and adenosine monophosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast.

UniProtKB/Swiss-Prot:67 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Genetics Home Reference:23 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:68 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the... more...

Description from OMIM:49 194200

Related Diseases for Wolff-Parkinson-White Syndrome

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Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

HPO human phenotypes related to Wolff-Parkinson-White Syndrome:

(show all 11)
id Description Frequency HPO Source Accession
1 arrhythmia hallmark (90%) HP:0011675
2 ventricular preexcitation with multiple accessory pathways HP:0006684
3 prolonged qrs complex HP:0006677
4 shortened pr interval HP:0005165
5 paroxysmal supraventricular tachycardia HP:0004763
6 paroxysmal atrial fibrillation HP:0004757
7 palpitations HP:0001962
8 wolff-parkinson-white syndrome HP:0001716
9 sudden cardiac death HP:0001645
10 cardiomyopathy HP:0001638
11 stroke HP:0001297

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECGCompletedNCT00251121
2Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory DuctTerminatedNCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Syndrome22 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

33
Heart, Lung, Breast, Brain, Liver, Thyroid, Kidney

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Osteopontin: a potential biomarker of Gaucher disease. (25875742)
2015
2
NKX2-1 mutations in brain-lung-thyroid syndrome: a case series of four patients. (24129101)
2014
3
Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A. (25428912)
2014
4
Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors. (24411949)
2014
5
Reproductive outcomes in patients with male infertility because of Klinefelter's syndrome, Kartagener's syndrome, round-head sperm, dysplasia fibrous sheath, and 'stump' tail sperm: an updated literature review. (23587797)
2013
6
Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. (22120717)
2012
7
Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors. (22426987)
2012
8
I+-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral I+-glucosidase inhibitor for improving postprandial hyperglycemia. (23106358)
2012
9
Mass spectrometric identification of novel posttranslational modification sites in Huntingtin. (22623107)
2012
10
Psychosocial effects of cleft lip and palate on Nigerians: the Ikeja-Lagos experience. (22455571)
2012
11
Plasmodium vivax infection in AnajA!s, State of ParA!: no differential resistance profile among Duffy-negative and Duffy-positive individuals. (23259672)
2012
12
Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation. (21707711)
2011
13
The human placenta expresses CYP17 and generates androgens de novo. (21307141)
2011
14
A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. (21771600)
2011
15
Bilirubin rebound after intensive phototherapy for neonatal jaundice. (20019393)
2010
16
Evaluation of serum levels of C-reactive protein and lipid profiles in patients with chronic periodontitis and/or coronary heart disease in an ethnic Han population. (20213025)
2010
17
Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. (20055865)
2009
18
Systematic review: the global incidence and prevalence of peptic ulcer disease. (19220208)
2009
19
Cancer immunotherapy using gammadelta T cells ex vivo expanded by bisphosphonate]. (18379032)
2008
20
Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule. (18678493)
2008
21
Rapidly progressing bilateral cataracts in a patient with beta thalassemia and pellagra. (17720090)
2007
22
Angiopoietin: a TIE(d) balance in tumor angiogenesis. (17634421)
2007
23
Changes of plasma inflammatory markers after withdrawal of statin therapy in patients with hyperlipidemia. (16343471)
2006
24
The absence of anti-Tat antibodies is associated with risk of disease progression in HIV-2 infection. (16941341)
2006
25
Electron cryotomography of the E. coli pyruvate and 2-oxoglutarate dehydrogenase complexes. (16338405)
2005
26
MRS reveals additional hexose N-acetyl resonances in the brain of a mouse model for Sandhoff disease. (16206131)
2005
27
Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation. (14976041)
2004
28
Antithrombotic therapy in peripheral arterial occlusive disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. (15383487)
2004
29
Spectrum of beta thalassemia mutations and HbF levels in the heterozygous Moroccan population. (12827652)
2003
30
The circularization of amyloid fibrils formed by apolipoprotein C-II. (14645087)
2003
31
Intravenous regional blocks with guanethidine and prilocaine combined with physiotherapy: two children with complex regional pain syndrome, type 1. (12095024)
2002
32
Intragraft cytokine expression in heart transplants with mild or no histological rejection. (11683815)
2001
33
Acute pharyngitis. (11357847)
2001
34
Expression of a novel factor, com1, in early tumor progression of breast cancer. (10815897)
2000
35
The law of unintended consequences in action: increase in incidence of hypokalemia with improved adequacy of dialysis. (11045278)
2000
36
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. (10910364)
2000
37
Targets for endothelin in the diseased kidney: clues for therapeutic intervention. (9892807)
1999
38
Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment. (10320650)
1999
39
Diffusion-limited reaction of free nitric oxide with erythrocytes. (9668042)
1998
40
Intercellular adhesion molecule-1 (ICAM-1) is expressed on human neutrophils and is essential for neutrophil adherence and aggregation. (9361346)
1997
41
Immune recognition of the 60kD heat shock protein: implications for subsequent fertility. (18476087)
1996
42
Allele-specific quantification of TNFA transcripts in rheumatoid arthritis. (8641702)
1996
43
Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP). (7850777)
1995
44
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
45
The CD14 differentiation antigen mediates the development of endotoxin responsiveness during differentiation of mononuclear phagocytes. (7517989)
1994
46
The oxygen status of arterial human blood. (2089613)
1990
47
Clear-cell adenocarcinoma of the female urethra. (3856984)
1985
48
Nursing care study--acute frontal sinusitis with associated osteitis. (281656)
1978
49
Trigger finger due to neurilemmoma in the carpal tunnel. (738662)
1978
50
Emphysematous cholecystitis; report of a case with successful treatment. (14847498)
1951

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

67
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRKAG2NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)single nucleotide variantPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.8PRKAA2, PRKAG2
29.4BMP2, NKX2-5
3
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
4
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
5
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
6
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
7
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
8
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
99.0PRKAA2, PRKAG2, PRKAG3
109.0PRKAA2, PRKAG2, PRKAG3
11
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
129.0PRKAA2, PRKAG2, PRKAG3
13
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
149.0PRKAA2, PRKAG2, PRKAG3
15
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
169.0PRKAA2, PRKAG2, PRKAG3
178.9BMP2, MYH7, NKX2-5
18
Show member pathways
8.9BMP2, MYH7, NKX2-5
198.5MYH7, PRKAA2, PRKAG2, PRKAG3
20
Show member pathways
8.5MYH7, PRKAA2, PRKAG2, PRKAG3
21
Show member pathways
8.5MYH7, PRKAA2, PRKAG2, PRKAG3
22
Show member pathways
8.5MT-CYB, PRKAA2, PRKAG2, PRKAG3

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:004230410.5PRKAA2, PRKAG2
2energy reserve metabolic processGO:000611210.1PRKAA2, PRKAG2
3positive regulation of osteoblast differentiationGO:004566910.0BMP2, JAG1
4cardiac muscle cell differentiationGO:00550079.9BMP2, NKX2-5
5cardiac muscle tissue morphogenesisGO:00550089.9BMP2, NKX2-5
6mitochondrion organizationGO:00070059.8PRKAA2, PRKAG3
7BMP signaling pathwayGO:00305099.8BMP2, NKX2-5
8macroautophagyGO:00162369.7PRKAA2, PRKAG3
9cell cycle arrestGO:00070509.5PRKAA2, PRKAG2, PRKAG3
10regulation of signal transduction by p53 class mediatorGO:19017969.4PRKAA2, PRKAG2, PRKAG3
11transcription initiation from RNA polymerase II promoterGO:00063679.1PRKAA2, PRKAG2, PRKAG3
12membrane organizationGO:00610249.0PRKAA2, PRKAG2, PRKAG3
13insulin receptor signaling pathwayGO:00082868.9PRKAA2, PRKAG2, PRKAG3
14organelle organizationGO:00069968.7PRKAA2, PRKAG2, PRKAG3
15protein phosphorylationGO:00064688.5BMP2, PRKAA2, PRKAG2, PRKAG3

Sources for Wolff-Parkinson-White Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet