MCID: WLF001
MIFTS: 73

Wolff-Parkinson-White Syndrome malady

Genetic diseases, Rare diseases, Cardiovascular diseases categories
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Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:42 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as anomalous atrioventricular excitation, is related to hypertrophic cardiomyopathy and tuberous sclerosis, and has symptoms including An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit), and among its related pathways are Heart Development and Regulation of autophagy. The drugs adenosine and adenosine monophosphate and the compounds metformin hydrochloride and pt 1 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord, and related mouse phenotypes are muscle and no phenotypic analysis.

Genetics Home Reference:21 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:65 Wolff?Parkinson?White syndrome (WPW) is one of several disorders of the conduction system of the heart... more...

Description from OMIM:46 194200

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Wolff-Parkinson-White Syndrome, Aliases & Descriptions:

Name: Wolff-Parkinson-White Syndrome 8 9 42 20 21 46 10 44 62
Anomalous Atrioventricular Excitation 8 10 62
Auriculoventricular Accessory Pathway Syndrome 42 62
Ventricular Pre-Excitation with Arrhythmia 21 62
Anomalous Ventricular Excitation Syndrome 42 62
Wolff-Parkinson-White Pattern 8 22
Wpw Syndrome 42 21
 
Ventricular Familial Preexcitation Syndrome 42
False Bundle Branch Block Syndrome 42
False Bundle-Branch Block Syndrome 62
Anomalous a-V Excitation 8
Pre-Excitation Syndromes 62
Preexcitation Syndrome 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:384
ICD9CM27 426.7
OMIM46 194200
NCIt39 C35132
MeSH34 D014927
ICD1025 I45.6

Related Diseases for Wolff-Parkinson-White Syndrome

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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic cardiomyopathy31.2PRKAG2, MYH7
2tuberous sclerosis31.0PRKAA1, PRKAA2
3ischemia30.4PRKAA1, PRKAA2, MYH7
4myocardial infarction10.9
5dilated cardiomyopathy10.7
6brugada syndrome10.7
7right bundle branch block10.6
8syncope10.6
9acute myocardial infarction10.5
10congestive heart failure10.5
11dextrocardia10.5
12familial hypertrophic cardiomyopathy10.5
13muscular dystrophy10.5
14transposition of the great arteries10.5
15tricuspid atresia10.5
16familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related10.5
17aneurysm10.5
18tetrology of fallot10.4NKX2-5
19sotos syndrome10.4
20alagille syndrome10.3
21ankylosing spondylitis10.3
22asthma10.3
23becker muscular dystrophy10.3
24duchenne muscular dystrophy10.3
25hemolytic anemia10.3
26schizophrenia10.3
27spinal cord injury10.3
28hypogonadotropism10.3
29hypokalemic periodic paralysis10.3
30leopard syndrome10.3
31lutembacher's syndrome10.3
32cocaine abuse10.3
33cardiac sarcoidosis10.3
34inferior myocardial infarction10.3
35lown-ganong-levine syndrome10.3
36peripartum cardiomyopathy10.3
37subacute bacterial endocarditis10.3
38danon disease10.3
39familial atrial fibrillation10.3
40rubella10.3
41scimitar syndrome10.3
42cerebritis10.3
43adenoma10.3
44cervicitis10.3
45endocarditis10.3
46hypogonadism10.3
47lactic acidosis10.3
48myocarditis10.3
49neuropathy10.3
50pneumonia10.3

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

HPO human phenotypes related to Wolff-Parkinson-White Syndrome:

(show all 9)
id Description Frequency HPO Source Accession
1 stroke HP:0001297
2 cardiomyopathy HP:0001638
3 sudden cardiac death HP:0001645
4 palpitations HP:0001962
5 paroxysmal atrial fibrillation HP:0004757
6 paroxysmal supraventricular tachycardia HP:0004763
7 shortened pr interval HP:0005165
8 prolonged qrs complex HP:0006677
9 ventricular preexcitation with multiple accessory pathways HP:0006684

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Drug clinical trials:

Search ClinicalTrials for Wolff-Parkinson-White Syndrome

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Syndrome20 PRKAG2
2 Wolff-Parkinson-White Pattern22

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

32
Heart, Testes, Spinal cord, Thyroid, Uterus, Atrioventricular node

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8NKX2-5, PRKAA1, PRKAA2, JAG1
2MP:00030128.1MYH7, JAG1, PRMT6, NKX2-5
3MP:00053767.8JAG1, PRKAG3, PRKAA2, PRKAA1, BMP2, NKX2-5
4MP:00053847.5NKX2-5, BMP2, PRKAA1, PRKAA2, PRMT6, JAG1

Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. (25269932)
2014
2
Multiple cardiac rhabdomyomas, wolff-Parkinson-white syndrome, and tuberous sclerosis: an infrequent combination. (25328743)
2014
3
LEOPARD syndrome with Wolff-Parkinson-White syndrome on electrocardiography. (24177621)
2013
4
Malignant arrhythmia as the first manifestation of Wolff-Parkinson-White syndrome: a case with minimal preexcitation on electrocardiography. (24831910)
2013
5
Anesthesia for Wolff-Parkinson-White syndrome: A report of two cases. (24015147)
2013
6
Electroconvulsive therapy-induced Wolff-Parkinson-White syndrome: a case report. (23517819)
2013
7
Deterioration of QT prolongation after successful catheter ablation for Wolff-Parkinson-White syndrome. (22087028)
2012
8
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
9
Transesophageal evaluation of asymptomatic Wolff-Parkinson-White syndrome. (22360708)
2012
10
Novel method of signal analysis for ablation of Wolff-Parkinson-White syndrome. (21872561)
2012
11
Computed tomography of a coronary sinus diverticulum associated with Wolff-Parkinson-White syndrome. (21699845)
2012
12
Accuracy of algorithms to predict accessory pathway location in children with Wolff-Parkinson-White syndrome. (21917661)
2012
13
Becker myotonia congenita associated with Wolff-Parkinson-White syndrome. (21192192)
2011
14
Septal dyskinesia and global left ventricular dysfunction in pediatric Wolff-Parkinson-White syndrome with septal accessory pathway. (19804548)
2010
15
Treadmill exercise test in Wolff-Parkinson-White syndrome. (20641113)
2010
16
ECG Diagnosis: Wolff-Parkinson-White Syndrome. (20740119)
2010
17
Clinical presentation and treatment of atrial fibrillation in Wolff-Parkinson-White syndrome. (20207273)
2010
18
Wolff-Parkinson-White syndrome associated with Brugada syndrome. (19513016)
2009
19
Amiodarone-induced torsade de pointes in a patient with wolff-Parkinson-White syndrome. (19465366)
2009
20
Management of asymptomatic Wolff-Parkinson-White syndrome. (19752209)
2009
21
Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. (17292982)
2008
22
Wolff-Parkinson-White syndrome with an unroofed coronary sinus without persistent left superior vena cava treated with catheter cryoablation. (18679525)
2008
23
Aborted sudden cardiac death revealing isolated noncompaction of the left ventricle in a patient with wolff-Parkinson-white syndrome. (17367369)
2007
24
Wolff-Parkinson-White syndrome in Patients With MELAS. (17998445)
2007
25
Wolff-Parkinson-White syndrome in athletes. (16934207)
2006
26
History of Wolff-Parkinson-White syndrome: introductory note to a classic article by Louis Wolff, MD, John Parkinson, MD, and Paul D White, MD. (17040282)
2006
27
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? (16686673)
2006
28
Wolff-Parkinson-white syndrome in d-transposition of the great arteries and mustard baffle. (16818221)
2006
29
Olanzapine-induced QTc prolongation in a patient with Wolff-Parkinson-White syndrome. (15061254)
2004
30
Mitochondrial hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome. (15340680)
2004
31
Molecular genetic analysis of PRKAG2 in sporadic Wolff-Parkinson-White syndrome. (12716108)
2003
32
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. (12782567)
2003
33
Non-invasive diagnosis of concealed Wolff-Parkinson-White syndrome by detection of concealed anterograde pre-excitation. (11348037)
2001
34
An unusual electrocardiographic pattern in a patient with Wolff-Parkinson-White syndrome. (10962757)
2000
35
Reciprocating tachycardia during central venous cannulation in a patient with Wolff-Parkinson-White syndrome. (10786754)
2000
36
Decreased amplitude of left ventricular posterior wall motion with notch movement to determine the left posterior septal accessory pathway in Wolff-Parkinson-White syndrome. (10573503)
1999
37
Anaesthetic considerations in a patient with wolff-Parkinson-white syndrome. (17846481)
1999
38
Wolff-Parkinson-White Syndrome. (11096476)
1999
39
Tachyarrhythmias in Wolff-Parkinson-White syndrome diagnosis and management. (11273256)
1998
40
Improved cardiac function after catheter ablation in a patient with type B Wolff-Parkinson-White syndrome with an old myocardial infarction. (9856605)
1998
41
The use of body surface potential map for identifying sites of accessory pathway in patients with Wolff-Parkinson-White syndrome. (9810295)
1998
42
False-positive 201thallium study in Wolff-Parkinson-White syndrome. (8640596)
1996
43
Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome progressing to ventricular dilation. (8644606)
1996
44
Body surface potential mapping of a patient with Wolff-Parkinson-White syndrome with two accessory pathways and two atrial pacemaker complexes. (8728600)
1996
45
Surgical cure of the Wolff-Parkinson-White syndrome--a comparison of two techniques. (7974042)
1994
46
Radiofrequency catheter ablation of atrioventricular accessory pathways in Wolff-Parkinson-White syndrome with drug-refractory and symptomatic supraventricular tachycardia--its high effectiveness irrespective of accessory pathway location and properties. (7966998)
1994
47
Radiofrequency catheter ablation for Wolff-Parkinson White syndrome. Part 2: Preventing complications. (7882861)
1994
48
Gated blood pool SPECT and phase analysis to assess simulated Wolff-Parkinson-White syndrome in the baboon. (8233841)
1993
49
Body surface distribution of abnormally low QRST areas in patients with Wolff-Parkinson-White syndrome. Evidence for continuation of repolarization abnormalities before and after catheter ablation. (8252678)
1993
50
Effects of flecainide on atrial electrophysiology in the Wolff-Parkinson-White syndrome. (1509996)
1992

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

64
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

6
id Gene Name Type Significance SNP ID Assembly Location
1PRKAG2NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)single nucleotide variantPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Expression patterns in normal tissues for genes affiliated with Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NKX2-5, BMP2
29.6PRKAA1, PRKAA2
39.2NKX2-5, BMP2, MYH7
4
Show member pathways
9.2MYH7, BMP2, NKX2-5
5
Show member pathways
9.1PRKAG2, PRKAA2, PRKAG3, MYH7
69.0BMP2, PRKAA1, PRKAA2
78.9PRKAG2, PRKAA1, PRKAA2, PRKAG3
88.9PRKAG2, PRKAA1, PRKAA2, PRKAG3
9
Show member pathways
8.9PRKAG2, PRKAA1, PRKAA2, PRKAG3
108.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
11
Show member pathways
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
12
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
13
Show member pathways
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
148.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
15
Show member pathways
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
16
Show member pathways
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
178.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
18
Show member pathways
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
19
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.9PRKAG3, PRKAA2, PRKAA1, PRKAG2
20
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.4PRKAG2, PRKAA1, PRKAA2, PRKAG3, MYH7
21
Show member pathways
8.4PRKAG3, PRKAA2, PRKAA1, PRKAG2, BMP2
22
Show member pathways
8.1AP2A2, PRKAG3, PRKAA2, PRKAA1, PRKAG2, MT-ND5
23
Show member pathways
7.9MYH7, PRKAG3, PRKAA2, PRKAA1, PRKAG2, BMP2
24
Show member pathways
7.4AP2A2, JAG1, PRKAG3, PRKAA2, PRKAA1, PRKAG2

Compounds for genes affiliated with Wolff-Parkinson-White Syndrome

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Compounds related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1metformin hydrochloride619.9PRKAA2, PRKAA1
2pt 1619.9PRKAA2, PRKAA1
3a 769662619.9PRKAA2, PRKAA1
4dorsomorphin dihydrochloride619.9PRKAA2, PRKAA1
5phenformin44 1110.8PRKAA1, PRKAA2
6acadesine449.8PRKAA1, PRKAA2
7aicar44 24 1111.8PRKAA1, PRKAA2
82-deoxyglucose44 1110.6PRKAA1, PRKAA2
9metformin44 50 1111.5PRKAA2, PRKAA1
10phosphocreatine44 2410.4PRKAA1, PRKAA2, MYH7
11leucine449.4MT-ND5, PRKAA2, MYH7
12glycogen44 2410.3PRKAG2, PRKAA1, PRKAA2
13rapamycin449.2PRKAA2, PRKAA1, BMP2
14wortmannin449.2BMP2, PRKAA1, PRKAA2
15atp44 289.9MYH7, PRKAA2, PRKAA1, MT-ND5
16creatinine448.8MYH7, PRKAA2, PRKAA1, BMP2
17nitric oxide44 24 1110.6JAG1, PRKAA2, PRKAA1, BMP2, NKX2-5
18threonine448.5MYH7, PRKAA2, PRKAA1, MT-ND5, BMP2
19lipid448.3BMP2, PRKAA1, PRKAA2, MYH7
20serine448.2MYH7, PRKAA2, PRKAA1, MT-ND5, BMP2, NKX2-5

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315888.9PRKAG2, PRKAA1, PRKAG3
2cytosolGO:0058297.6PRKAG2, PRKAA1, PRKAA2, PRKAG3, PRMT6, AP2A2

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:04230410.3PRKAA2, PRKAG2
2carnitine shuttleGO:00685310.2PRKAA2, PRKAG2
3adult heart developmentGO:00751210.0MYH7, NKX2-5
4cardiac muscle tissue morphogenesisGO:0550089.9BMP2, NKX2-5
5regulation of energy homeostasisGO:20005059.9PRKAA2, PRKAA1
6cellular response to nutrient levelsGO:0316699.9PRKAA2, PRKAA1
7hemopoiesisGO:0300979.9JAG1, NKX2-5
8fatty acid homeostasisGO:0550899.9PRKAA1, PRKAA2
9positive regulation of glycolytic processGO:0458219.9PRKAA2, PRKAA1
10cardiac muscle cell differentiationGO:0550079.9BMP2, NKX2-5
11lipid biosynthetic processGO:0086109.9PRKAA1, PRKAA2
12regulation of circadian rhythmGO:0427529.9PRKAA1, PRKAA2
13cellular response to glucose starvationGO:0421499.8PRKAA1, PRKAA2
14membrane organizationGO:0610249.8PRKAG2, PRKAA2, PRKAG3
15rhythmic processGO:0485119.8PRKAA2, PRKAA1
16positive regulation of autophagyGO:0105089.8PRKAA1, PRKAA2
17negative regulation of TOR signalingGO:0320079.8PRKAA1, PRKAA2
18BMP signaling pathwayGO:0305099.8NKX2-5, BMP2
19cholesterol biosynthetic processGO:0066959.8PRKAA1, PRKAA2
20positive regulation of neuron differentiationGO:0456669.7NKX2-5, BMP2
21autophagyGO:0069149.7PRKAA1, PRKAA2
22negative regulation of canonical Wnt signaling pathwayGO:0900909.6NKX2-5, BMP2
23glucose homeostasisGO:0425939.5PRKAA1, PRKAA2
24fatty acid biosynthetic processGO:0066339.3PRKAG2, PRKAA1, PRKAA2, PRKAG3
25cell cycle arrestGO:0070509.3PRKAG3, PRKAA2, PRKAA1, PRKAG2
26insulin receptor signaling pathwayGO:0082869.3PRKAG3, PRKAA2, PRKAA1, PRKAG2
27protein phosphorylationGO:0064689.0BMP2, PRKAA1, PRKAA2, PRKAG3
28negative regulation of apoptotic processGO:0430668.9NKX2-5, PRKAA1, PRKAA2
29negative regulation of transcription, DNA-templatedGO:0458928.8PRMT6, BMP2, NKX2-5

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1[acetyl-CoA carboxylase] kinase activityGO:0504059.7PRKAA2, PRKAA1
2[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityGO:0473229.6PRKAA2, PRKAA1
3histone serine kinase activityGO:0351749.6PRKAA1, PRKAA2
4AMP-activated protein kinase activityGO:0046799.3PRKAA1, PRKAA2, PRKAG3
5chromatin bindingGO:0036829.2NKX2-5, PRKAA1, PRKAA2
6ATP bindingGO:0055248.1MYH7, PRKAG3, PRKAA2, PRKAA1, PRKAG2
7protein bindingGO:0055156.4AP2A2, MYH7, JAG1, PRMT6, PRKAA2, PRKAA1

Products for genes affiliated with Wolff-Parkinson-White Syndrome

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Sources for Wolff-Parkinson-White Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet