MCID: WLF001
MIFTS: 57

Wolff-Parkinson-White Syndrome malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 51 11 47 24 25 69 26 12 49 38 13 67
Preexcitation Syndrome 47 24 67
Ventricular Familial Preexcitation Syndrome 47 69
Anomalous Atrioventricular Excitation 11 67
Wolff-Parkinson-White Pattern 11 26
Wpw Syndrome 47 25
Auriculoventricular Accessory Pathway Syndrome 47
 
Ventricular Pre-Excitation with Arrhythmia 25
Anomalous Ventricular Excitation Syndrome 47
False Bundle Branch Block Syndrome 47
Ventricular Preexcitation 67
Anomalous a-V Excitation 11
Wpws 69

Classifications:



External Ids:

OMIM51 194200
Disease Ontology11 DOID:384
ICD1029 I45.6
ICD9CM31 426.7
MeSH38 D014927
NCIt44 C35132

Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:47 Wolff-Parkinson-White syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). People with Wolff-Parkinson-White syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  This abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by mutations in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner.  Last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to cardiomyopathy, hypertrophic 6 and familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related, and has symptoms including arrhythmia, stroke and cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and Heart Development. The drugs adenosine phosphate sodium and adenosine triphosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid, and related mouse phenotype muscle.

Genetics Home Reference:25 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot:69 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia:70 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the... more...

Description from OMIM:51 194200

Related Diseases for Wolff-Parkinson-White Syndrome

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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy, hypertrophic 627.8BMP2, CBS, JAG1, MT-ND5, MYH7, NKX2-5
2familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related12.3
3atrial fibrillation10.9
4cardiomyopathy10.7
5myocardial infarction10.6
6dilated cardiomyopathy10.4
7brugada syndrome10.3
8right bundle branch block10.3
9syncope10.3
10polymicrogyria10.3PRKAA2, PRKAG2
11tricuspid atresia10.1
12acute myocardial infarction10.1
13congestive heart failure10.1
14cardiac arrest10.1
15thyroiditis10.1
16myocarditis10.1
17dextrocardia10.1
18muscular dystrophy10.1
19transposition of the great arteries10.1
20sudden cardiac death10.1
21aneurysm10.1
22epileptic encephalopathy, early infantile, 910.0LAMP2, PRKAG2
23schizophrenia10.0
24asthma10.0
25leigh syndrome10.0
26danon disease10.0
27alagille syndrome10.0
28duchenne muscular dystrophy10.0
29becker muscular dystrophy10.0
30pulmonary atresia with intact ventricular septum10.0
31hemolytic anemia10.0
32spinal cord injury10.0
33familial atrial fibrillation10.0
34endocarditis10.0
35heart disease10.0
36gestational diabetes10.0
37cardiac sarcoidosis10.0
38epilepsy10.0
39hypogonadism10.0
40lutembacher's syndrome10.0
41cervicitis10.0
42ischemia10.0
43cerebritis10.0
44lactic acidosis10.0
45subacute bacterial endocarditis10.0
46placenta accreta10.0
47pneumonia10.0
48inferior myocardial infarction10.0
49adenoma10.0
50spondylitis10.0

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Ischemic Heart DiseaseFamilial Atrial Fibrillation
Heart DiseaseMitral Valve Disease
Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

 63 (show all 11)
id Description HPO Frequency HPO Source Accession
1 arrhythmia63 hallmark (90%) HP:0011675
2 stroke63 HP:0001297
3 cardiomyopathy63 HP:0001638
4 sudden cardiac death63 HP:0001645
5 wolff-parkinson-white syndrome63 HP:0001716
6 palpitations63 HP:0001962
7 paroxysmal atrial fibrillation63 HP:0004757
8 paroxysmal supraventricular tachycardia63 HP:0004763
9 shortened pr interval63 HP:0005165
10 prolonged qrs complex63 HP:0006677
11 ventricular preexcitation with multiple accessory pathways63 HP:0006684

UMLS symptoms related to Wolff-Parkinson-White Syndrome:


fetal tachycardia, fetal bradycardia

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECGCompletedNCT00251121
2Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory DuctTerminatedNCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern26
2 Wolff-Parkinson-White Syndrome26 24 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

35
Heart, Testes, Thyroid, Spinal cord, Atrioventricular node, Placenta, Uterus

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2JAG1, LAMP2, MYH7, NKX2-5, PRKAA2

Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 573)
idTitleAuthorsYear
1
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. (27815796)
2017
2
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. (26719390)
2016
3
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. (26361569)
2015
4
Letter by Fenici et al Regarding Articles, "Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation: Insights From a Registry Study of 2169 Patients" and "The Asymptomatic Wolff-Parkinson-White Patient: Time to be More Proactive?". (25986451)
2015
5
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. (26256551)
2015
6
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. (25269932)
2014
7
The occurrence of atrial fibrillation in Wolff-Parkinson-White syndrome. (24694559)
2014
8
Anesthesia for Wolff-Parkinson-White syndrome: A report of two cases. (24015147)
2013
9
Deterioration of QT prolongation after successful catheter ablation for Wolff-Parkinson-White syndrome. (22087028)
2012
10
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
11
Atrial fibrillation and Wolff-Parkinson-White syndrome: mechanisms revisited? (22171958)
2012
12
A case of supraventricular tachycardia associated with Wolff-Parkinson-White syndrome and pregnancy. (23189456)
2012
13
Becker myotonia congenita associated with Wolff-Parkinson-White syndrome. (21192192)
2011
14
Septal dyskinesia and global left ventricular dysfunction in pediatric Wolff-Parkinson-White syndrome with septal accessory pathway. (19804548)
2010
15
Amiodarone-induced torsade de pointes in a patient with wolff-Parkinson-White syndrome. (19465366)
2009
16
Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. (17292982)
2008
17
Emergency department bedside echocardiography in diagnosis of Ebstein's anomaly with Wolff-Parkinson-White syndrome and atrial fibrillation. (18821863)
2008
18
When should we recommend catheter ablation for patients with the Wolff-Parkinson-White syndrome? (18281825)
2008
19
Aborted sudden cardiac death revealing isolated noncompaction of the left ventricle in a patient with wolff-Parkinson-white syndrome. (17367369)
2007
20
Wolff-Parkinson-White syndrome in athletes. (16934207)
2006
21
History of Wolff-Parkinson-White syndrome: introductory note to a classic article by Louis Wolff, MD, John Parkinson, MD, and Paul D White, MD. (17040282)
2006
22
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? (16686673)
2006
23
Olanzapine-induced QTc prolongation in a patient with Wolff-Parkinson-White syndrome. (15061254)
2004
24
Mitochondrial hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome. (15340680)
2004
25
Wolff-Parkinson-White syndrome in previously undiagnosed Ebstein's anomaly. (15080278)
2004
26
Repeated supraventricular tachycardia in an asymptomatic patient with Wolff-Parkinson-White syndrome during Cesarean delivery. (12944457)
2003
27
Atrial fibrillation in patients with Wolff-Parkinson-White syndrome. (11942587)
2002
28
Non-invasive diagnosis of concealed Wolff-Parkinson-White syndrome by detection of concealed anterograde pre-excitation. (11348037)
2001
29
An unusual electrocardiographic pattern in a patient with Wolff-Parkinson-White syndrome. (10962757)
2000
30
Reciprocating tachycardia during central venous cannulation in a patient with Wolff-Parkinson-White syndrome. (10786754)
2000
31
Anaesthetic considerations in a patient with wolff-Parkinson-white syndrome. (17846481)
1999
32
Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome. (10355918)
1999
33
Tachyarrhythmias in Wolff-Parkinson-White syndrome diagnosis and management. (11273256)
1998
34
Improved cardiac function after catheter ablation in a patient with type B Wolff-Parkinson-White syndrome with an old myocardial infarction. (9856605)
1998
35
The use of body surface potential map for identifying sites of accessory pathway in patients with Wolff-Parkinson-White syndrome. (9810295)
1998
36
Apparent bradycardia-dependent block in the accessory pathway in intermittent Wolff-Parkinson-White syndrome. (9588662)
1998
37
Identifying patients with Wolff-Parkinson-White Syndrome. (9718598)
1998
38
Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome progressing to ventricular dilation. (8644606)
1996
39
Body surface potential mapping of a patient with Wolff-Parkinson-White syndrome with two accessory pathways and two atrial pacemaker complexes. (8728600)
1996
40
Wolff-Parkinson-White syndrome in a cardiac allograft. (7887725)
1995
41
Surgical treatment of patients with Wolff-Parkinson-White syndrome and associated Ebstein's anomaly. (8523883)
1995
42
Ventricular fibrillation following adenosine therapy for supraventricular tachycardia in a neonate with concealed Wolff-Parkinson-White syndrome treated with digoxin. (8532572)
1995
43
Surgical cure of the Wolff-Parkinson-White syndrome--a comparison of two techniques. (7974042)
1994
44
Radiofrequency catheter ablation of atrioventricular accessory pathways in Wolff-Parkinson-White syndrome with drug-refractory and symptomatic supraventricular tachycardia--its high effectiveness irrespective of accessory pathway location and properties. (7966998)
1994
45
Gated blood pool SPECT and phase analysis to assess simulated Wolff-Parkinson-White syndrome in the baboon. (8233841)
1993
46
Should radiofrequency current ablation be performed in asymptomatic patients with the Wolff-Parkinson-White syndrome? (7681970)
1993
47
Biplanar transesophageal echocardiographic direction of radiofrequency catheter ablation in children and adolescents with the Wolff-Parkinson-White syndrome. (8456773)
1993
48
Effects of flecainide on atrial electrophysiology in the Wolff-Parkinson-White syndrome. (1509996)
1992
49
Flecainide in the Wolff-Parkinson-White syndrome. (1509995)
1992
50
Modification of the electrocardiogram of myocardial infarction by anomalous atrioventricular excitation; Wolff-Parkinson-White syndrome. (18123053)
1949

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

69
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264rs121908987
2PRKAG2p.Arg531GlyVAR_032909rs121908990

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRKAG2NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)SNVPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.3BMP2, NKX2-5
3
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
4
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
5
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
6
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
7
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
8
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
99.0PRKAA2, PRKAG2, PRKAG3
10
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
119.0PRKAA2, PRKAG2, PRKAG3
129.0PRKAA2, PRKAG2, PRKAG3
139.0PRKAA2, PRKAG2, PRKAG3
149.0PRKAA2, PRKAG2, PRKAG3
158.9BMP2, MYH7, NKX2-5
16
Show member pathways
8.9BMP2, MYH7, NKX2-5
178.6MYH7, PRKAA2, PRKAG2, PRKAG3
188.6CBS, PRKAA2, PRKAG2, PRKAG3

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleotide-activated protein kinase complexGO:00315889.0PRKAA2, PRKAG2, PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:004230410.5PRKAA2, PRKAG2
2carnitine shuttleGO:000685310.3PRKAA2, PRKAG2
3adult heart developmentGO:000751210.0MYH7, NKX2-5
4cardiac muscle tissue morphogenesisGO:00550089.9BMP2, NKX2-5
5cardiac muscle cell differentiationGO:00550079.9BMP2, NKX2-5
6positive regulation of osteoblast differentiationGO:00456699.8BMP2, JAG1
7macroautophagyGO:00162369.5PRKAA2, PRKAG2, PRKAG3
8cardiac muscle contractionGO:00600489.4MYH7, NKX2-5
9fatty acid biosynthetic processGO:00066339.3PRKAA2, PRKAG2, PRKAG3
10inner ear developmentGO:00488399.3BMP2, JAG1
11cell cycle arrestGO:00070509.1PRKAA2, PRKAG2, PRKAG3
12regulation of signal transduction by p53 class mediatorGO:19017969.0PRKAA2, PRKAG2, PRKAG3
13protein phosphorylationGO:00064688.4BMP2, PRKAA2, PRKAG2, PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase activityGO:00046799.0PRKAA2, PRKAG2, PRKAG3

Sources for Wolff-Parkinson-White Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet