MCID: WLF001
MIFTS: 58

Wolff-Parkinson-White Syndrome malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 50 11 46 23 24 13 68 25 12 48 37 66
Preexcitation Syndrome 46 23 66
Ventricular Familial Preexcitation Syndrome 46 68
Anomalous Atrioventricular Excitation 11 66
Wolff-Parkinson-White Pattern 11 25
Wpw Syndrome 46 24
Auriculoventricular Accessory Pathway Syndrome 46
 
Ventricular Pre-Excitation with Arrhythmia 24
Anomalous Ventricular Excitation Syndrome 46
False Bundle Branch Block Syndrome 46
Ventricular Preexcitation 66
Anomalous a-V Excitation 11
Wpws 68

Classifications:



External Ids:

OMIM50 194200
Disease Ontology11 DOID:384
ICD1028 I45.6
ICD9CM30 426.7
MeSH37 D014927
NCIt43 C35132

Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:46 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to cardiomyopathy, hypertrophic 6 and familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related, and has symptoms including arrhythmia, stroke and cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and Heart Development. The drugs adenosine and adenosine monophosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid.

UniProtKB/Swiss-Prot:68 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Genetics Home Reference:24 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:69 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the... more...

Description from OMIM:50 194200

Related Diseases for Wolff-Parkinson-White Syndrome

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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy, hypertrophic 626.7BMP2, CBS, JAG1, MT-CYB, MT-ND5, MYH7
2familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related12.4
3atrial fibrillation11.0
4cardiomyopathy10.8
5myocardial infarction10.7
6dilated cardiomyopathy10.5
7hypertrophic cardiomyopathy10.5
8brugada syndrome10.5
9right bundle branch block10.4
10tuberous sclerosis10.4
11syncope10.4
12lown-ganong-levine syndrome10.4
13tricuspid atresia10.3
14acute myocardial infarction10.3
15congestive heart failure10.3
16cardiac arrest10.3
17thyroiditis10.3
18myocarditis10.3
19dextrocardia10.3
20muscular dystrophy10.3
21transposition of the great arteries10.3
22sudden cardiac death10.3
23aneurysm10.3
24polymicrogyria10.2PRKAA2, PRKAG2
25schizophrenia10.1
26asthma10.1
27leigh syndrome10.1
28danon disease10.1
29alagille syndrome10.1
30duchenne muscular dystrophy10.1
31becker muscular dystrophy10.1
32pulmonary atresia with intact ventricular septum10.1
33hemolytic anemia10.1
34spinal cord injury10.1
35familial atrial fibrillation10.1
36endocarditis10.1
37heart disease10.1
38gestational diabetes10.1
39cardiac sarcoidosis10.1
40leopard syndrome10.1
41epilepsy10.1
42hypogonadism10.1
43lutembacher's syndrome10.1
44myotonia congenita10.1
45cervicitis10.1
46ischemia10.1
47cerebritis10.1
48lactic acidosis10.1
49subacute bacterial endocarditis10.1
50placenta accreta10.1

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Intermediate Coronary SyndromeIschemic Heart Disease
Mitral Valve DiseaseFamilial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

HPO human phenotypes related to Wolff-Parkinson-White Syndrome:

(show all 11)
id Description Frequency HPO Source Accession
1 arrhythmia hallmark (90%) HP:0011675
2 stroke HP:0001297
3 cardiomyopathy HP:0001638
4 sudden cardiac death HP:0001645
5 wolff-parkinson-white syndrome HP:0001716
6 palpitations HP:0001962
7 paroxysmal atrial fibrillation HP:0004757
8 paroxysmal supraventricular tachycardia HP:0004763
9 shortened pr interval HP:0005165
10 prolonged qrs complex HP:0006677
11 ventricular preexcitation with multiple accessory pathways HP:0006684

UMLS symptoms related to Wolff-Parkinson-White Syndrome:


fetal tachycardia, fetal bradycardia

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECGCompletedNCT00251121
2Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory DuctTerminatedNCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern25
2 Wolff-Parkinson-White Syndrome25 23 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

34
Heart, Testes, Thyroid, Atrioventricular node, Kidney, Placenta, Uterus

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 568)
idTitleAuthorsYear
1
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. (26719390)
2016
2
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. (26361569)
2015
3
Letter by Fenici et al Regarding Articles, "Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation: Insights From a Registry Study of 2169 Patients" and "The Asymptomatic Wolff-Parkinson-White Patient: Time to be More Proactive?". (25986451)
2015
4
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. (26256551)
2015
5
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. (25269932)
2014
6
The occurrence of atrial fibrillation in Wolff-Parkinson-White syndrome. (24694559)
2014
7
Anesthesia for Wolff-Parkinson-White syndrome: A report of two cases. (24015147)
2013
8
Deterioration of QT prolongation after successful catheter ablation for Wolff-Parkinson-White syndrome. (22087028)
2012
9
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
10
Atrial fibrillation and Wolff-Parkinson-White syndrome: mechanisms revisited? (22171958)
2012
11
A case of supraventricular tachycardia associated with Wolff-Parkinson-White syndrome and pregnancy. (23189456)
2012
12
Becker myotonia congenita associated with Wolff-Parkinson-White syndrome. (21192192)
2011
13
Septal dyskinesia and global left ventricular dysfunction in pediatric Wolff-Parkinson-White syndrome with septal accessory pathway. (19804548)
2010
14
Amiodarone-induced torsade de pointes in a patient with wolff-Parkinson-White syndrome. (19465366)
2009
15
Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. (17292982)
2008
16
Emergency department bedside echocardiography in diagnosis of Ebstein's anomaly with Wolff-Parkinson-White syndrome and atrial fibrillation. (18821863)
2008
17
When should we recommend catheter ablation for patients with the Wolff-Parkinson-White syndrome? (18281825)
2008
18
Aborted sudden cardiac death revealing isolated noncompaction of the left ventricle in a patient with wolff-Parkinson-white syndrome. (17367369)
2007
19
Wolff-Parkinson-White syndrome in athletes. (16934207)
2006
20
History of Wolff-Parkinson-White syndrome: introductory note to a classic article by Louis Wolff, MD, John Parkinson, MD, and Paul D White, MD. (17040282)
2006
21
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? (16686673)
2006
22
Olanzapine-induced QTc prolongation in a patient with Wolff-Parkinson-White syndrome. (15061254)
2004
23
Mitochondrial hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome. (15340680)
2004
24
Wolff-Parkinson-White syndrome in previously undiagnosed Ebstein's anomaly. (15080278)
2004
25
Repeated supraventricular tachycardia in an asymptomatic patient with Wolff-Parkinson-White syndrome during Cesarean delivery. (12944457)
2003
26
Atrial fibrillation in patients with Wolff-Parkinson-White syndrome. (11942587)
2002
27
Non-invasive diagnosis of concealed Wolff-Parkinson-White syndrome by detection of concealed anterograde pre-excitation. (11348037)
2001
28
Identification of mtDNA mutation in a pedigree with gestational diabetes, deafness, Wolff-Parkinson-White syndrome and placenta accreta. (11096278)
2001
29
An unusual electrocardiographic pattern in a patient with Wolff-Parkinson-White syndrome. (10962757)
2000
30
Reciprocating tachycardia during central venous cannulation in a patient with Wolff-Parkinson-White syndrome. (10786754)
2000
31
Anaesthetic considerations in a patient with wolff-Parkinson-white syndrome. (17846481)
1999
32
Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome. (10355918)
1999
33
Tachyarrhythmias in Wolff-Parkinson-White syndrome diagnosis and management. (11273256)
1998
34
Improved cardiac function after catheter ablation in a patient with type B Wolff-Parkinson-White syndrome with an old myocardial infarction. (9856605)
1998
35
The use of body surface potential map for identifying sites of accessory pathway in patients with Wolff-Parkinson-White syndrome. (9810295)
1998
36
Apparent bradycardia-dependent block in the accessory pathway in intermittent Wolff-Parkinson-White syndrome. (9588662)
1998
37
Identifying patients with Wolff-Parkinson-White Syndrome. (9718598)
1998
38
Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome progressing to ventricular dilation. (8644606)
1996
39
Body surface potential mapping of a patient with Wolff-Parkinson-White syndrome with two accessory pathways and two atrial pacemaker complexes. (8728600)
1996
40
Wolff-Parkinson-White syndrome in a cardiac allograft. (7887725)
1995
41
Surgical treatment of patients with Wolff-Parkinson-White syndrome and associated Ebstein's anomaly. (8523883)
1995
42
Ventricular fibrillation following adenosine therapy for supraventricular tachycardia in a neonate with concealed Wolff-Parkinson-White syndrome treated with digoxin. (8532572)
1995
43
Surgical cure of the Wolff-Parkinson-White syndrome--a comparison of two techniques. (7974042)
1994
44
Radiofrequency catheter ablation of atrioventricular accessory pathways in Wolff-Parkinson-White syndrome with drug-refractory and symptomatic supraventricular tachycardia--its high effectiveness irrespective of accessory pathway location and properties. (7966998)
1994
45
Gated blood pool SPECT and phase analysis to assess simulated Wolff-Parkinson-White syndrome in the baboon. (8233841)
1993
46
Should radiofrequency current ablation be performed in asymptomatic patients with the Wolff-Parkinson-White syndrome? (7681970)
1993
47
Biplanar transesophageal echocardiographic direction of radiofrequency catheter ablation in children and adolescents with the Wolff-Parkinson-White syndrome. (8456773)
1993
48
Effects of flecainide on atrial electrophysiology in the Wolff-Parkinson-White syndrome. (1509996)
1992
49
Flecainide in the Wolff-Parkinson-White syndrome. (1509995)
1992
50
Modification of the electrocardiogram of myocardial infarction by anomalous atrioventricular excitation; Wolff-Parkinson-White syndrome. (18123053)
1949

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

68
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264rs121908987
2PRKAG2p.Arg531GlyVAR_032909rs121908990

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRKAG2NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)single nucleotide variantPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.4BMP2, NKX2-5
3
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
4
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
5
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
6
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
7
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
8
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
9
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
109.0PRKAA2, PRKAG2, PRKAG3
119.0PRKAA2, PRKAG2, PRKAG3
12
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
139.0PRKAA2, PRKAG2, PRKAG3
149.0PRKAA2, PRKAG2, PRKAG3
15
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
169.0PRKAA2, PRKAG2, PRKAG3
179.0BMP2, MYH7, NKX2-5
18
Show member pathways
9.0BMP2, MYH7, NKX2-5
198.6MYH7, PRKAA2, PRKAG2, PRKAG3
20
Show member pathways
8.6MYH7, PRKAA2, PRKAG2, PRKAG3
218.5CBS, PRKAA2, PRKAG2, PRKAG3
22
Show member pathways
8.5MT-CYB, PRKAA2, PRKAG2, PRKAG3

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleotide-activated protein kinase complexGO:00315889.0PRKAA2, PRKAG2, PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:004230410.5PRKAA2, PRKAG2
2carnitine shuttleGO:000685310.3PRKAA2, PRKAG2
3cardiac muscle tissue morphogenesisGO:005500810.0BMP2, NKX2-5
4cardiac muscle cell differentiationGO:005500710.0BMP2, NKX2-5
5response to organonitrogen compoundGO:00102439.9MT-CYB, MT-ND5
6adult heart developmentGO:00075129.9MYH7, NKX2-5
7inner ear developmentGO:00488399.8BMP2, JAG1
8fatty acid biosynthetic processGO:00066339.5PRKAA2, PRKAG2, PRKAG3
9macroautophagyGO:00162369.5PRKAA2, PRKAG2, PRKAG3
10positive regulation of osteoblast differentiationGO:00456699.4BMP2, JAG1
11cardiac muscle contractionGO:00600489.3MYH7, NKX2-5
12cell cycle arrestGO:00070509.2PRKAA2, PRKAG2, PRKAG3
13regulation of signal transduction by p53 class mediatorGO:19017969.0PRKAA2, PRKAG2, PRKAG3
14protein phosphorylationGO:00064688.6BMP2, PRKAA2, PRKAG2, PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase activityGO:00046799.0PRKAA2, PRKAG2, PRKAG3

Sources for Wolff-Parkinson-White Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
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44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet