MCID: WLF001
MIFTS: 57

Wolff-Parkinson-White Syndrome

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

MalaCards integrated aliases for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 53 12 49 24 71 28 13 51 41 14 69
Wpw Syndrome 53 49 24
Ventricular Familial Preexcitation Syndrome 49 71
Anomalous Atrioventricular Excitation 12 69
Wolff-Parkinson-White Pattern 12 28
Preexcitation Syndrome 49 69
Auriculoventricular Accessory Pathway Syndrome 49
Ventricular Pre-Excitation with Arrhythmia 24
Anomalous Ventricular Excitation Syndrome 49
False Bundle Branch Block Syndrome 49
Wolff-Parkinson-White Syndrome 36
Ventricular Preexcitation 69
Anomalous a-V Excitation 12
Wpws 71

Characteristics:

OMIM:

53
Inheritance:
? autosomal dominant factor


Classifications:



Summaries for Wolff-Parkinson-White Syndrome

NIH Rare Diseases : 49 Wolff-Parkinson-White syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). People with Wolff-Parkinson-White syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  This abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by mutations in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner.  Last updated: 12/31/2012

MalaCards based summary : Wolff-Parkinson-White Syndrome, also known as wpw syndrome, is related to hypertrophic cardiomyopathy and atrial standstill 1, and has symptoms including sudden cardiac death, cardiomyopathy and stroke. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Insulin signaling pathway and Adipocytokine signaling pathway. The drug Menthol has been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid.

Genetics Home Reference : 24 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot : 71 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia : 72 Wolff–Parkinson–White syndrome (WPW) is a disorder due to a specific type of problem with the electrical... more...

Description from OMIM: 194200

Related Diseases for Wolff-Parkinson-White Syndrome

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 hypertrophic cardiomyopathy 30.0 MYH7 NPPB PRKAA2 PRKAG2
2 atrial standstill 1 30.0 MYH7 NPPB PRKAG2
3 transposition of the great arteries 29.8 NKX2-5 NPPB
4 heart disease 28.6 JAG1 MYH7 NKX2-5 NPPB
5 cardiomyopathy, familial hypertrophic, 6 11.7
6 cardiomyopathy, infantile histiocytoid 11.3
7 20p12.3 microdeletion syndrome 11.3
8 myoclonic epilepsy associated with ragged-red fibers 11.0
9 atrial fibrillation 10.9
10 myocardial infarction 10.7
11 ventricular fibrillation, paroxysmal familial, 1 10.6
12 dilated cardiomyopathy 10.5
13 progressive familial heart block, type ia 10.5
14 aging 10.4
15 brugada syndrome 10.4
16 progressive familial heart block, type ib 10.3
17 right bundle branch block 10.3
18 tuberous sclerosis 10.3
19 syncope 10.3
20 aneurysm 10.3
21 phosphorylase kinase deficiency 10.3 PRKAA2 PRKAG2
22 cardiac conduction defect 10.2
23 tricuspid atresia 10.2
24 episodic pain syndrome, familial, 1 10.2
25 acute myocardial infarction 10.2
26 congestive heart failure 10.2
27 cardiac arrest 10.2
28 thyroiditis 10.2
29 myocarditis 10.2
30 dextrocardia 10.2
31 muscular dystrophy 10.2
32 double discordia 10.2
33 third-degree atrioventricular block 10.1 NPPB PRKAG2
34 spondyloarthropathy 1 10.0
35 total anomalous pulmonary venous return 1 10.0
36 alagille syndrome 1 10.0
37 hypokalemic periodic paralysis, type 1 10.0
38 schizophrenia 10.0
39 scleroderma, familial progressive 10.0
40 tuberous sclerosis 1 10.0
41 leigh syndrome 10.0
42 pulmonary atresia with intact ventricular septum 10.0
43 danon disease 10.0
44 muscular dystrophy, becker type 10.0
45 muscular dystrophy, duchenne type 10.0
46 asthma 10.0
47 stroke, ischemic 10.0
48 branchiootic syndrome 1 10.0
49 blood group, junior system 10.0
50 peripartum cardiomyopathy 10.0

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to Wolff-Parkinson-White Syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

Symptoms via clinical synopsis from OMIM:

53
Cardiac:
palpitations
short pr interval and prolonged qrs, with slurred-up stroke of the r wave (delta wave) on ekg
paroxysmal supraventricular tachycardia
paroxysmal atrial fibrillation
familial cardiomyopathy
more

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

31 (show all 10)
# Description HPO Frequency HPO Source Accession
1 sudden cardiac death 31 HP:0001645
2 cardiomyopathy 31 HP:0001638
3 wolff-parkinson-white syndrome 31 HP:0001716
4 stroke 31 HP:0001297
5 palpitations 31 HP:0001962
6 shortened pr interval 31 HP:0005165
7 paroxysmal supraventricular tachycardia 31 HP:0004763
8 paroxysmal atrial fibrillation 31 HP:0004757
9 prolonged qrs complex 31 HP:0006677
10 ventricular preexcitation with multiple accessory pathways 31 HP:0006684

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Drugs for Wolff-Parkinson-White Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Completed NCT00251121
2 Risk Assessment in Patients With Symptomatic- and Asymptomatic Preexcitation Recruiting NCT03301935
3 Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern Enrolling by invitation NCT03207373
4 Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory Duct Terminated NCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

Genetic tests related to Wolff-Parkinson-White Syndrome:

# Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern 28 PRKAG2
2 Wolff-Parkinson-White Syndrome 28

Anatomical Context for Wolff-Parkinson-White Syndrome

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

38
Heart, Testes, Thyroid, Spinal Cord, Placenta, Uterus, Atrioventricular Node

Publications for Wolff-Parkinson-White Syndrome

Articles related to Wolff-Parkinson-White Syndrome:

(show top 50) (show all 587)
# Title Authors Year
1
Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study. ( 29068040 )
2018
2
MY APPROACH to the Athlete With Wolff-Parkinson-White Syndrome (WPW). ( 29032933 )
2018
3
Supraventricular tachycardia in a trauma patient masquerading as a Wolff-Parkinson-White syndrome. ( 28927735 )
2017
4
The impact of left ventricular deformation and dyssynchrony on improvement of left ventricular ejection fraction following radiofrequency catheter ablation in Wolff-Parkinson-White syndrome: A comprehensive study by speckle tracking echocardiography. ( 28929532 )
2017
5
Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: long-term risk of mortality and coronary events. ( 28605443 )
2017
6
Characterisation of three-dimensional mapping in Wolff-Parkinson-White syndrome with septal aneurysmal dyskinesis. ( 28847328 )
2017
7
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. ( 27815796 )
2017
8
Reversal of Wolff-Parkinson-White Syndrome induced dilated cardiomyopathy via resynchronization and subsequent accessory pathway ablation. ( 29238369 )
2017
9
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. ( 28214246 )
2017
10
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. ( 28084962 )
2017
11
Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian Family. ( 28690312 )
2017
12
Successful ablation of a right atrium-axillary ventricular accessory pathway associated with Wolff-Parkinson-White syndrome. ( 28543607 )
2017
13
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. ( 28491758 )
2017
14
A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult. ( 29115093 )
2017
15
Depression masquerading as chest pain in a patient with Wolff Parkinson White syndrome. ( 27738505 )
2016
16
The Wolff-Parkinson-White Syndrome: A Test Bed for the Assessment of Myocardial Dyssynchrony? ( 27307557 )
2016
17
Physiological Expression of AMPKI^2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice. ( 27621313 )
2016
18
Noninvasive Localization of Accessory Pathways in Wolff-Parkinson-White Syndrome by Three-Dimensional Speckle Tracking Echocardiography. ( 27307551 )
2016
19
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. ( 27042562 )
2016
20
PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population. ( 27866917 )
2016
21
Wolff-Parkinson-White Syndrome in a Term Infant Presenting With Cardiopulmonary Arrest. ( 26742096 )
2016
22
Localization Of Accessory Pathway In Patients With Wolff-Parkinson-White Syndrome From Surface Ecg Using Arruda Algorithm. ( 28712209 )
2016
23
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. ( 27555124 )
2016
24
The impact of B-type natriuretic peptide levels on the suppression of accompanying atrial fibrillation in Wolff-Parkinson-White syndrome patients after accessory pathway ablation. ( 26917195 )
2016
25
Spontaneous Transition of Double Tachycardias with Atrial Fusion in a Patient with Wolff-Parkinson-White Syndrome. ( 27482269 )
2016
26
Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff-Parkinson-White syndrome: Uneven depression of accessory pathway conduction. ( 28491747 )
2016
27
Detecting Regional Myocardial Abnormalities in Patients With Wolff-Parkinson-White Syndrome With the Use of ECG-Gated Cardiac MDCT. ( 26866341 )
2016
28
Tachyarrhythmia in Wolff-Parkinson-White Syndrome. ( 27429700 )
2016
29
Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading. ( 27869041 )
2016
30
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. ( 26719390 )
2016
31
Treatment of Wolff-Parkinson-White Syndrome With a Thoracoscopic Surgical Procedure. ( 26140800 )
2015
32
Accessory conduction pathway ablated by myocarditis in a patient with Wolff-Parkinson-White syndrome. ( 26520696 )
2015
33
Letter by Fenici et al Regarding Articles, "Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation: Insights From a Registry Study of 2169 Patients" and "The Asymptomatic Wolff-Parkinson-White Patient: Time to be More Proactive?". ( 25986451 )
2015
34
Wolff-Parkinson-White syndrome with bundle branch and fascicular block: The diagnostic clue of electrocardiogram. ( 25497533 )
2015
35
Utility of Exercise Testing and Adenosine Response for Risk Assessment in Children with Wolff-Parkinson-White Syndrome. ( 26010236 )
2015
36
Supraventricular Tachycardia Cardioverted by an Automated External Debrillator in a 9-year-old Male with a History of Wolff-Parkinson-White Syndrome. ( 25664915 )
2015
37
Atrial Fibrillation in a 35-Year-Old Man with Wolff-Parkinson-White Syndrome. ( 26504453 )
2015
38
Wolff-Parkinson-White syndrome: comprehensive electrophysiologic assessment with the help of a single PVC. ( 26120612 )
2015
39
Comparison of the accuracy of three algorithms in predicting accessory pathways among adult Wolff-Parkinson-White syndrome patients. ( 26384677 )
2015
40
MY APPROACH to Wolff-Parkinson-White syndrome. ( 25592237 )
2015
41
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. ( 26361569 )
2015
42
Swallowing-induced atrial tachyarrhythmias successfully ablated at the left posterior interatrial septum in patient with wolff-Parkinson-white syndrome. ( 26023316 )
2015
43
Extracorporeal life support for cardiac arrest in a 13-year-old girl caused by Wolff-Parkinson-White syndrome. ( 26314214 )
2015
44
Atrial fibrillation with Wolff-Parkinson-White syndrome in epilepsy: A potentially fatal combination. ( 26552553 )
2015
45
Thyroid storm in a patient with Wolff-Parkinson-White syndrome. ( 26670895 )
2015
46
Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. ( 26284702 )
2015
47
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. ( 26256551 )
2015
48
Variable primary phenotypic manifestations in a rare familial form of Wolff-Parkinson-White syndrome and hypertrophic cardiomyopathy. ( 26333379 )
2015
49
A young patient with atypical type-B Wolff-Parkinson-White syndrome accompanied by left ventricular dysfunction. ( 26336525 )
2015
50
50th anniversary landmark commentary on Sealy WC, Hattler BG Jr, Blumenschein SD, Cobb FR. Surgical treatment of Wolff-Parkinson-White syndrome. Ann Thorac Surg 1969;8:1-11. ( 25742810 )
2015

Variations for Wolff-Parkinson-White Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

71
# Symbol AA change Variation ID SNP ID
1 PRKAG2 p.Arg302Gln VAR_013264 rs121908987
2 PRKAG2 p.Arg531Gly VAR_032909 rs121908990

ClinVar genetic disease variations for Wolff-Parkinson-White Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh37 Chromosome 7, 151273498: 151273498
2 PRKAG2 NM_016203.3(PRKAG2): c.547G> A (p.Glu183Lys) single nucleotide variant Pathogenic rs1131692281 GRCh37 Chromosome 7, 151372643: 151372643

Expression for Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for Wolff-Parkinson-White Syndrome

Pathways related to Wolff-Parkinson-White Syndrome according to KEGG:

36
# Name Kegg Source Accession
1 Insulin signaling pathway hsa04910
2 Adipocytokine signaling pathway hsa04920
3 Hypertrophic cardiomyopathy (HCM) hsa05410

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 MYH7 NPPB PRKAA2 PRKAG2 PRKAG3
2
Show member pathways
12.29 PRKAA2 PRKAG2 PRKAG3
3 12.28 CBS PRKAA2 PRKAG2 PRKAG3
4
Show member pathways
12.24 MYH7 NKX2-5 NPPB
5
Show member pathways
12.21 PRKAA2 PRKAG2 PRKAG3
6
Show member pathways
12.19 PRKAA2 PRKAG2 PRKAG3
7
Show member pathways
12.01 PRKAA2 PRKAG2 PRKAG3
8 12 PRKAA2 PRKAG2 PRKAG3
9
Show member pathways
11.97 PRKAA2 PRKAG2 PRKAG3
10
Show member pathways
11.94 PRKAA2 PRKAG2 PRKAG3
11
Show member pathways
11.93 PRKAA2 PRKAG2 PRKAG3
12
Show member pathways
11.91 MYH7 PRKAA2 PRKAG2 PRKAG3
13
Show member pathways
11.88 PRKAA2 PRKAG2 PRKAG3
14
Show member pathways
11.87 PRKAA2 PRKAG2 PRKAG3
15
Show member pathways
11.76 PRKAA2 PRKAG2 PRKAG3
16 11.71 PRKAA2 PRKAG2 PRKAG3
17 11.62 PRKAA2 PRKAG2 PRKAG3
18 11.59 JAG1 PRKAA2 PRKAG2 PRKAG3
19 11.52 PRKAA2 PRKAG2 PRKAG3
20 11.47 PRKAA2 PRKAG2 PRKAG3
21 11.32 PRKAA2 PRKAG2 PRKAG3
22
Show member pathways
11.21 PRKAA2 PRKAG2 PRKAG3
23 11.05 PRKAA2 PRKAG2 PRKAG3
24 10.72 MYH7 PRKAA2 PRKAG2 PRKAG3
25 10.58 PRKAA2 PRKAG2
26 10.47 MYH7 NKX2-5 NPPB

GO Terms for Wolff-Parkinson-White Syndrome

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide-activated protein kinase complex GO:0031588 8.8 PRKAA2 PRKAG2 PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.63 PRKAA2 PRKAG2 PRKAG3
2 cell cycle arrest GO:0007050 9.61 PRKAA2 PRKAG2 PRKAG3
3 regulation of signal transduction by p53 class mediator GO:1901796 9.58 PRKAA2 PRKAG2 PRKAG3
4 cardiac muscle contraction GO:0060048 9.49 MYH7 NKX2-5
5 sterol biosynthetic process GO:0016126 9.48 PRKAA2 PRKAG2
6 macroautophagy GO:0016236 9.43 PRKAA2 PRKAG2 PRKAG3
7 adult heart development GO:0007512 9.37 MYH7 NKX2-5
8 carnitine shuttle GO:0006853 9.32 PRKAA2 PRKAG2
9 regulation of fatty acid biosynthetic process GO:0042304 9.16 PRKAA2 PRKAG2
10 fatty acid biosynthetic process GO:0006633 9.13 PRKAA2 PRKAG2 PRKAG3
11 regulation of macroautophagy GO:0016241 8.8 PRKAA2 PRKAG2 PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AMP-activated protein kinase activity GO:0004679 8.8 PRKAA2 PRKAG2 PRKAG3

Sources for Wolff-Parkinson-White Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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