MCID: WLF001
MIFTS: 57

Wolff-Parkinson-White Syndrome malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 52 11 48 24 25 70 27 12 50 39 13 68
Preexcitation Syndrome 48 24 68
Ventricular Familial Preexcitation Syndrome 48 70
Anomalous Atrioventricular Excitation 11 68
Wolff-Parkinson-White Pattern 11 27
Wpw Syndrome 48 25
Auriculoventricular Accessory Pathway Syndrome 48
 
Ventricular Pre-Excitation with Arrhythmia 25
Anomalous Ventricular Excitation Syndrome 48
False Bundle Branch Block Syndrome 48
Ventricular Preexcitation 68
Anomalous a-V Excitation 11
Wpws 70

Classifications:



External Ids:

OMIM52 194200
Disease Ontology11 DOID:384
ICD1030 I45.6
ICD9CM32 426.7
MeSH39 D014927
NCIt45 C35132

Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:48 Wolff-Parkinson-White syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). People with Wolff-Parkinson-White syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  This abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by mutations in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner.  Last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to cardiomyopathy, hypertrophic 6 and familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related, and has symptoms including arrhythmia, stroke and cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and Heart Development. The drugs adenosine phosphate sodium and adenosine triphosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid, and related mouse phenotype muscle.

Genetics Home Reference:25 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot:70 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia:71 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the... more...

Description from OMIM:52 194200

Related Diseases for Wolff-Parkinson-White Syndrome

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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy, hypertrophic 627.8BMP2, CBS, JAG1, MT-ND5, MYH7, NKX2-5
2familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related12.3
3atrial fibrillation10.9
4cardiomyopathy10.7
5myocardial infarction10.6
6dilated cardiomyopathy10.4
7brugada syndrome10.3
8right bundle branch block10.3
9syncope10.3
10polymicrogyria10.3PRKAA2, PRKAG2
11tricuspid atresia10.1
12acute myocardial infarction10.1
13congestive heart failure10.1
14cardiac arrest10.1
15thyroiditis10.1
16myocarditis10.1
17dextrocardia10.1
18muscular dystrophy10.1
19transposition of the great arteries10.1
20sudden cardiac death10.1
21aneurysm10.1
22epileptic encephalopathy, early infantile, 910.0LAMP2, PRKAG2
23schizophrenia10.0
24asthma10.0
25leigh syndrome10.0
26danon disease10.0
27alagille syndrome10.0
28duchenne muscular dystrophy10.0
29becker muscular dystrophy10.0
30pulmonary atresia with intact ventricular septum10.0
31hemolytic anemia10.0
32spinal cord injury10.0
33familial atrial fibrillation10.0
34endocarditis10.0
35heart disease10.0
36gestational diabetes10.0
37cardiac sarcoidosis10.0
38epilepsy10.0
39hypogonadism10.0
40lutembacher's syndrome10.0
41cervicitis10.0
42ischemia10.0
43cerebritis10.0
44lactic acidosis10.0
45subacute bacterial endocarditis10.0
46placenta accreta10.0
47pneumonia10.0
48inferior myocardial infarction10.0
49adenoma10.0
50spondylitis10.0

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Intermediate Coronary SyndromeIschemic Heart Disease
Mitral Valve DiseaseFamilial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

 64 (show all 11)
id Description HPO Frequency HPO Source Accession
1 arrhythmia64 hallmark (90%) HP:0011675
2 stroke64 HP:0001297
3 cardiomyopathy64 HP:0001638
4 sudden cardiac death64 HP:0001645
5 wolff-parkinson-white syndrome64 HP:0001716
6 palpitations64 HP:0001962
7 paroxysmal atrial fibrillation64 HP:0004757
8 paroxysmal supraventricular tachycardia64 HP:0004763
9 shortened pr interval64 HP:0005165
10 prolonged qrs complex64 HP:0006677
11 ventricular preexcitation with multiple accessory pathways64 HP:0006684

UMLS symptoms related to Wolff-Parkinson-White Syndrome:


fetal tachycardia, fetal bradycardia

MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2JAG1, LAMP2, MYH7, NKX2-5, PRKAA2

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECGCompletedNCT00251121
2Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory DuctTerminatedNCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern27
2 Wolff-Parkinson-White Syndrome27 24 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

36
Heart, Testes, Thyroid, Spinal cord, Atrioventricular node, Placenta, Uterus

Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 573)
idTitleAuthorsYear
1
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. (27815796)
2017
2
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. (28084962)
2017
3
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. (26719390)
2016
4
Wolff-Parkinson-White Syndrome in a Term Infant Presenting With Cardiopulmonary Arrest. (26742096)
2016
5
The Wolff-Parkinson-White Syndrome: A Test Bed for the Assessment of Myocardial Dyssynchrony? (27307557)
2016
6
Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading. (27869041)
2016
7
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. (27042562)
2016
8
The impact of B-type natriuretic peptide levels on the suppression of accompanying atrial fibrillation in Wolff-Parkinson-White syndrome patients after accessory pathway ablation. (26917195)
2016
9
Detecting Regional Myocardial Abnormalities in Patients With Wolff-Parkinson-White Syndrome With the Use of ECG-Gated Cardiac MDCT. (26866341)
2016
10
Noninvasive Localization of Accessory Pathways in Wolff-Parkinson-White Syndrome by Three-Dimensional Speckle Tracking Echocardiography. (27307551)
2016
11
Physiological Expression of AMPKI^2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice. (27621313)
2016
12
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. (27555124)
2016
13
PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population. (27866917)
2016
14
Depression masquerading as chest pain in a patient with Wolff Parkinson White syndrome. (27738505)
2016
15
Tachyarrhythmia in Wolff-Parkinson-White Syndrome. (27429700)
2016
16
Spontaneous Transition of Double Tachycardias with Atrial Fusion in a Patient with Wolff-Parkinson-White Syndrome. (27482269)
2016
17
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. (26361569)
2015
18
Letter by Fenici et al Regarding Articles, "Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation: Insights From a Registry Study of 2169 Patients" and "The Asymptomatic Wolff-Parkinson-White Patient: Time to be More Proactive?". (25986451)
2015
19
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. (26256551)
2015
20
Response to letter regarding article, "Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients". (25986452)
2015
21
Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. (26284702)
2015
22
Atrial Fibrillation in a 35-Year-Old Man with Wolff-Parkinson-White Syndrome. (26504453)
2015
23
Thyroid storm in a patient with Wolff-Parkinson-White syndrome. (26670895)
2015
24
Swallowing-induced atrial tachyarrhythmias successfully ablated at the left posterior interatrial septum in patient with wolff-Parkinson-white syndrome. (26023316)
2015
25
Treatment of Wolff-Parkinson-White Syndrome With a Thoracoscopic Surgical Procedure. (26140800)
2015
26
Supraventricular Tachycardia Cardioverted by an Automated External Debrillator in a 9-year-old Male with a History of Wolff-Parkinson-White Syndrome. (25664915)
2015
27
Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation. (26480930)
2015
28
Utility of Exercise Testing and Adenosine Response for Risk Assessment in Children with Wolff-Parkinson-White Syndrome. (26010236)
2015
29
Wolff-Parkinson-White syndrome with bundle branch and fascicular block: The diagnostic clue of electrocardiogram. (25497533)
2015
30
Wolff-Parkinson-White syndrome: comprehensive electrophysiologic assessment with the help of a single PVC. (26120612)
2015
31
50th anniversary landmark commentary on Sealy WC, Hattler BG Jr, Blumenschein SD, Cobb FR. Surgical treatment of Wolff-Parkinson-White syndrome. Ann Thorac Surg 1969;8:1-11. (25742810)
2015
32
Variable primary phenotypic manifestations in a rare familial form of Wolff-Parkinson-White syndrome and hypertrophic cardiomyopathy. (26333379)
2015
33
MY APPROACH to Wolff-Parkinson-White syndrome. (25592237)
2015
34
Accessory conduction pathway ablated by myocarditis in a patient with Wolff-Parkinson-White syndrome. (26520696)
2015
35
Extracorporeal life support for cardiac arrest in a 13-year-old girl caused by Wolff-Parkinson-White syndrome. (26314214)
2015
36
Atrial fibrillation with Wolff-Parkinson-White syndrome in epilepsy: A potentially fatal combination. (26552553)
2015
37
Comparison of the accuracy of three algorithms in predicting accessory pathways among adult Wolff-Parkinson-White syndrome patients. (26384677)
2015
38
A young patient with atypical type-B Wolff-Parkinson-White syndrome accompanied by left ventricular dysfunction. (26336525)
2015
39
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. (25269932)
2014
40
The occurrence of atrial fibrillation in Wolff-Parkinson-White syndrome. (24694559)
2014
41
Noninvasive risk stratification for sudden death in asymptomatic patients with Wolff-Parkinson-White syndrome. (25662922)
2014
42
Members of the emergency medical team may have difficulty diagnosing rapid atrial fibrillation in Wolff-Parkinson-White syndrome. (25428731)
2014
43
Exercise testing in children with Wolff-Parkinson-White syndrome: what is its value? (24728424)
2014
44
Recurrence of accessory pathway after radiofrequency ablation from a benign to a malignant form of Wolff-Parkinson-White syndrome: a very uncommon case. (24692515)
2014
45
Wolff-Parkinson-White syndrome unmasked by atrial pacing in a patient with cardiac sarcoidosis. (24696224)
2014
46
Tachydysrhythmia treatment and adverse events in patients with wolff-Parkinson-white syndrome. (24880554)
2014
47
Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: the long-term mortality and risk of atrial fibrillation. (25013013)
2014
48
Multiple cardiac rhabdomyomas, wolff-Parkinson-white syndrome, and tuberous sclerosis: an infrequent combination. (25328743)
2014
49
Perioperative management of the Wolff-Parkinson-White syndrome. (25027102)
2014
50
Assessment of atrial fibrillation and vulnerability in patients with wolff-Parkinson-white syndrome using two-dimensional speckle tracking echocardiography. (25397668)
2014

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

70
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264rs121908987
2PRKAG2p.Arg531GlyVAR_032909rs121908990

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRKAG2NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)SNVPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.3BMP2, NKX2-5
3
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
4
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
5
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
6
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
7
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
8
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
99.0PRKAA2, PRKAG2, PRKAG3
10
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
119.0PRKAA2, PRKAG2, PRKAG3
129.0PRKAA2, PRKAG2, PRKAG3
139.0PRKAA2, PRKAG2, PRKAG3
149.0PRKAA2, PRKAG2, PRKAG3
158.9BMP2, MYH7, NKX2-5
16
Show member pathways
8.9BMP2, MYH7, NKX2-5
178.6MYH7, PRKAA2, PRKAG2, PRKAG3
188.6CBS, PRKAA2, PRKAG2, PRKAG3

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleotide-activated protein kinase complexGO:00315889.0PRKAA2, PRKAG2, PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1carnitine shuttleGO:000685310.6PRKAA2, PRKAG2
2regulation of fatty acid biosynthetic processGO:004230410.4PRKAA2, PRKAG2
3inner ear developmentGO:004883910.3BMP2, JAG1
4positive regulation of osteoblast differentiationGO:004566910.3BMP2, JAG1
5adult heart developmentGO:000751210.2MYH7, NKX2-5
6cardiac muscle contractionGO:006004810.2MYH7, NKX2-5
7cardiac muscle cell differentiationGO:005500710.0BMP2, NKX2-5
8cardiac muscle tissue morphogenesisGO:005500810.0BMP2, NKX2-5
9cell cycle arrestGO:00070509.7PRKAA2, PRKAG2, PRKAG3
10fatty acid biosynthetic processGO:00066339.7PRKAA2, PRKAG2, PRKAG3
11macroautophagyGO:00162369.7PRKAA2, PRKAG2, PRKAG3
12protein phosphorylationGO:00064689.1BMP2, PRKAA2, PRKAG2, PRKAG3
13regulation of signal transduction by p53 class mediatorGO:19017969.0PRKAA2, PRKAG2, PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase activityGO:00046799.0PRKAA2, PRKAG2, PRKAG3

Sources for Wolff-Parkinson-White Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet