MCID: WLF001
MIFTS: 65

Wolff-Parkinson-White Syndrome malady

Cardiovascular diseases, Genetic diseases categories

Summaries for Wolff-Parkinson-White Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards: Wolff-Parkinson-White Syndrome, also known as wolff parkinson white syndrome, is related to hypertrophic cardiomyopathy and familial hypertrophic cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and AMPK inhibits chREBP transcriptional activation activity. The drugs adenosine and adenosine monophosphate and the compounds metformin hydrochloride and pt 1 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Genetics Home Reference:21 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:63 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the... more...

Description from OMIM:46 194200

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

wolff-parkinson-white syndrome 8 9 42 21 46 10 44 60
wolff parkinson white syndrome 8 20
wolff-parkinson-white pattern 8 22
auriculoventricular accessory pathway syndrome 42
ventricular familial preexcitation syndrome 42
ventricular pre-excitation with arrhythmia 21
anomalous ventricular excitation syndrome 42
false bundle branch block syndrome 42
parkinson disease, late-onset 60
pre-excitation syndromes 60
wolff-park-white syndr. 8
preexcitation syndrome 42
wpw syndrome 21


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Disease Ontology8 DOID:384
OMIM46 194200
NCIt39 C35132
MeSH34 D014927
ICD1025 I45.6

Related Diseases for Wolff-Parkinson-White Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic cardiomyopathy30.9MYH7, PRKAG2
2familial hypertrophic cardiomyopathy30.6MYH7
3glycogen storage disease30.4PRKAG2
4myocardial infarction10.9
5image syndrome10.9
6dilated cardiomyopathy10.7
7brugada syndrome10.7
8anomalous atrioventricular excitation10.7
9right bundle branch block10.6
10tuberous sclerosis10.5
11acute myocardial infarction10.5
12dextrocardia10.4
13inferior myocardial infarction10.4
14congestive heart failure10.4
15muscular dystrophy10.4
16familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related10.4
17parkinson disease, late-onset10.3
18sotos syndrome10.3
19atrioventricular block10.3
20lown-ganong-levine syndrome10.3
21leopard syndrome10.3
22ankylosing spondylitis10.3
23lutembacher's syndrome10.3
24coronary aneurysm10.3
25cerebritis10.3
26arrhythmogenic right ventricular dysplasia10.3
27danon disease10.3
28placenta accreta10.3
29melas syndrome10.3
30alagille syndrome10.3
31becker muscular dystrophy10.3
32duchenne muscular dystrophy10.3
33gestational diabetes10.3
34peripartum cardiomyopathy10.3
35familial atrial fibrillation10.3
36scimitar syndrome10.3
37cocaine abuse10.3
38hypogonadotropism10.3
39subacute bacterial endocarditis10.3
40adult syndrome10.3
41hypokalemic periodic paralysis10.3
42adenoma10.3
43asthma10.3
44cervicitis10.3
45coronary stenosis10.3
46endocarditis10.3
47hemolytic anemia10.3
48hypogonadism10.3
49ischemia10.3
50lactic acidosis10.3

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Clinical Features for Wolff-Parkinson-White Syndrome

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46OMIM
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Clinical features from OMIM:

194200

Clinical synopsis from OMIM:

194200

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Wolff-Parkinson-White Syndrome

Drug clinical trials:

Search ClinicalTrials for Wolff-Parkinson-White Syndrome

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Search CenterWatch for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Wolff-Parkinson-White Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Syndrome20 PRKAG2
2 Wolff-Parkinson-White Pattern22

Anatomical Context for Wolff-Parkinson-White Syndrome

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32MalaCards
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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

32
Heart, Testes, Spinal cord, Thyroid, Uterus, Placenta, Atrioventricular node

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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Publications for Wolff-Parkinson-White Syndrome

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Sources:
50PubMed
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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Bundle branch block after ablation for Wolff-Parkinson-White syndrome. (23073281)
2013
2
Accuracy of algorithms to predict accessory pathway location in children with Wolff-Parkinson-White syndrome. (21917661)
2012
3
Clinical and electrophysiologic characteristics of antidromic tachycardia in children with Wolff-Parkinson-White syndrome. (22324823)
2012
4
The prevalence of early repolarization in Wolff-Parkinson-White syndrome with a special reference to J waves and the effects of catheter ablation. (21705015)
2012
5
Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome. (23118663)
2012
6
Emergency treatment of Wolff-Parkinson-White syndrome. (21384785)
2011
7
Reversion of left ventricular systolic dysfunction and abnormal stress test: by catheter ablation, in a patient with Wolff-Parkinson-White syndrome from Para-Hisian Kent bundle. (20844629)
2010
8
Examining the causes of ablation failure in the Wolff-Parkinson-White syndrome. (20466814)
2010
9
Wolff-Parkinson-White syndrome associated with Brugada syndrome. (19513016)
2009
10
Wolff-Parkinson-White syndrome: where is the pathway? (19308285)
2009
11
Images in cardiovascular medicine. Wolff-Parkinson-White syndrome and atrial fibrillation in a patient with a coronary sinus diverticulum. (17515469)
2007
12
Alternans Wolff-Parkinson-White syndrome: supernormal conduction as an alternative mechanism. (17306292)
2007
13
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? (16686673)
2006
14
Wolff-Parkinson-White syndrome mimicking acute inferolateral myocardial ischaemia in pneumonia. (16377057)
2006
15
The mechanism of sudden death in the Wolff-Parkinson-White syndrome. (16403081)
2005
16
Should catheter ablation be performed in asymptomatic patients with Wolff-Parkinson-White syndrome? Catheter ablation should be performed in asymptomatic patients with Wolff-Parkinson-White syndrome. (16208793)
2005
17
Right atrial rhabdomyoma acting as the substrate for Wolff-Parkinson-White syndrome in a 3-month-old infant. (16261787)
2005
18
History of Wolff-Parkinson-White syndrome. (15679646)
2005
19
Wolff-Parkinson-White syndrome: essentials for the primary care nurse practitioner. (15495691)
2004
20
Atrial electrophysiologic abnormalities in patients with Wolff-Parkinson-White syndrome but without paroxysmal atrial fibrillation. (15298039)
2004
21
Molecular genetic analysis of PRKAG2 in sporadic Wolff-Parkinson-White syndrome. (12716108)
2003
22
Classifying cases of fetal Wolff-Parkinson-White syndrome by estimating the accessory pathway from fetal magnetocardiograms. (12572745)
2003
23
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. (12397075)
2002
24
Surgically repaired delayed mitral regurgitation after radiofrequency catheter ablation for Wolff-Parkinson-White syndrome. (12164459)
2002
25
Spontaneously terminating apparent ventricular fibrillation during transesophageal electrophysiological testing in infants with Wolff-Parkinson-White syndrome. (11817818)
2001
26
Gender and atrioventricular conduction properties of patients with symptomatic atrioventricular nodal reentrant tachycardia and Wolff-Parkinson-White syndrome. (11590556)
2001
27
Signal averaging in Wolff-Parkinson-White syndrome: evidence that fractionated activation is not necessary for body surface high-frequency potentials. (11025887)
2000
28
Long-term prospective study on the natural history of Wolff-Parkinson-White syndrome detected during a heart screening program at school. (10852188)
2000
29
Noninvasive localization of accessory pathways in patients with Wolff-Parkinson-White syndrome with the use of myocardial Doppler imaging. (9882776)
1999
30
Postoperative influences of surgical cryoablation for Wolff-Parkinson-White syndrome--a analysis of myocardial enzymes and function. (9192239)
1997
31
Body surface potential mapping of a patient with Wolff-Parkinson-White syndrome with two accessory pathways and two atrial pacemaker complexes. (8728600)
1996
32
A case report of simultaneous surgery for Wolff-Parkinson-White syndrome combined with hemolytic anemia and mitral stenosis. (8741243)
1996
33
Body surface distribution of significant changes in QRST time-integral values after radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome. (8540459)
1996
34
Surgical treatment of patients with Wolff-Parkinson-White syndrome and associated Ebstein's anomaly. (8523883)
1995
35
QRST time integral values in 12-lead electrocardiograms before and after radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome. (7759709)
1995
36
Wolff-Parkinson-White syndrome presenting as the permanent form of junctional reciprocating tachycardia. (7780628)
1995
37
A case of septal Wolff-Parkinson-White syndrome associated with newly developed delta waves due to disappearance of impedance mismatch. (7897339)
1995
38
The ECG in Wolff-Parkinson-White syndrome. (7479167)
1995
39
Catheter ablation using radiofrequency or low-energy direct current in pediatric patients with the Wolff-Parkinson-White syndrome. (8296742)
1994
40
Surgical treatment of patients with Wolff-Parkinson-White syndrome and associated acquired valvular heart disease. (8028381)
1994
41
Surgical ablation of Wolff-Parkinson-White syndrome in children and young adults. (8176779)
1994
42
Surgical treatment of Wolff-Parkinson-White syndrome in infants and children. (8037505)
1994
43
Gated blood pool SPECT and phase analysis to assess simulated Wolff-Parkinson-White syndrome in the baboon. (8233841)
1993
44
Surgical treatment of the Wolff-Parkinson-White syndrome in children. (8076099)
1993
45
Association of a Wolff-Parkinson-White syndrome and a fistula from the coronary to the pulmonary artery. (8447186)
1993
46
Atrial fibrillation in the Wolff-Parkinson-White syndrome. (1509997)
1992
47
Wolff-Parkinson-White syndrome. A quantitative morphometric analysis of surgical anatomy. (1513169)
1992
48
Operative results after unsuccessful radiofrequency ablation for Wolff-Parkinson-White syndrome. (1442625)
1992
49
Catheter ablation of free wall accessory atrioventricular pathways in 89 patients with Wolff-Parkinson-White syndrome--comparison of direct current and radiofrequency ablation. (1396804)
1992
50
Modification of the electrocardiogram of myocardial infarction by anomalous atrioventricular excitation; Wolff-Parkinson-White syndrome. (18123053)
1949

Genetic Variations for Wolff-Parkinson-White Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Wolff-Parkinson-White Syndrome:

62
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.9PRKAA2, PRKAG2
39.6NKX2-5, BMP2
49.6PRKAA1, PRKAA2
5
Hide members
9.5PRKAG2, PRKAA2, PRKAG3
6
Hide members
9.2MYH7, NKX2-5, BMP2
79.2MYH7, NKX2-5, BMP2
89.0BMP2, PRKAA2, PRKAA1
98.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
10
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
11
Translation Insulin regulation of translation
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
128.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
13
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
148.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
15
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
168.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
17
Development Leptin signaling via PI3K-dependent pathway
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
188.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
198.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
208.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
21
Hide members
8.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2
22
Hide members
8.3BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1
23
Hide members
8.0AP2A2, MT-ND5, PRKAG2, PRKAA2, PRKAG3, PRKAA1
24
Hide members
7.9BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1, MYH7
25
Hide members
7.4AP2A2, BMP2, JAG1, PRKAG2, PRKAA2, PRKAG3

Compounds for genes affiliated with Wolff-Parkinson-White Syndrome

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1metformin hydrochloride599.8PRKAA2, PRKAA1
2pt 1599.8PRKAA2, PRKAA1
3a 769662599.8PRKAA2, PRKAA1
4dorsomorphin dihydrochloride599.8PRKAA2, PRKAA1
5phenformin44 1110.7PRKAA1, PRKAA2
6acadesine449.6PRKAA2, PRKAA1
7phosphocreatine44 2410.4MYH7, PRKAA1, PRKAA2
8aicar44 11 2411.3PRKAA2, PRKAA1
9rapamycin449.0PRKAA1, PRKAA2, BMP2
10nitric oxide44 11 2410.5BMP2, JAG1, PRKAA2, PRKAA1, NKX2-5
11creatinine448.5MYH7, PRKAA1, PRKAA2, BMP2
12threonine448.4BMP2, MT-ND5, PRKAA2, PRKAA1, MYH7
13serine448.0MYH7, NKX2-5, PRKAA1, PRKAA2, MT-ND5, BMP2

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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16Gene Ontology
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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315889.2PRKAA1, PRKAG3, PRKAG2

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:04230410.2PRKAG2, PRKAA2
2carnitine shuttleGO:00685310.1PRKAG2, PRKAA2
3regulation of energy homeostasisGO:20005059.9PRKAA1, PRKAA2
4regulation of circadian rhythmGO:0427529.8PRKAA1, PRKAA2
5fatty acid homeostasisGO:0550899.8PRKAA2, PRKAA1
6cardiac muscle tissue morphogenesisGO:0550089.8BMP2, NKX2-5
7cellular response to nutrient levelsGO:0316699.8PRKAA2, PRKAA1
8adult heart developmentGO:0075129.8NKX2-5, MYH7
9positive regulation of glycolysisGO:0458219.8PRKAA1, PRKAA2
10lipid biosynthetic processGO:0086109.7PRKAA2, PRKAA1
11cellular response to glucose starvationGO:0421499.7PRKAA1, PRKAA2
12rhythmic processGO:0485119.6PRKAA1, PRKAA2
13positive regulation of autophagyGO:0105089.6PRKAA1, PRKAA2
14cholesterol biosynthetic processGO:0066959.6PRKAA1, PRKAA2
15negative regulation of TOR signaling cascadeGO:0320079.5PRKAA2, PRKAA1
16cardiac muscle cell differentiationGO:0550079.3NKX2-5, BMP2
17fatty acid biosynthetic processGO:0066339.2PRKAA1, PRKAG3, PRKAA2, PRKAG2
18cell cycle arrestGO:0070509.2PRKAG2, PRKAA2, PRKAG3, PRKAA1
19insulin receptor signaling pathwayGO:0082869.2PRKAG2, PRKAA2, PRKAG3, PRKAA1

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityGO:0473229.6PRKAA1, PRKAA2
2[acetyl-CoA carboxylase] kinase activityGO:0504059.5PRKAA1, PRKAA2
3histone serine kinase activityGO:0351749.3PRKAA2, PRKAA1
4AMP-activated protein kinase activityGO:0046799.2PRKAA1, PRKAG3, PRKAA2
5ATP bindingGO:0055248.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2

Products for genes affiliated with Wolff-Parkinson-White Syndrome

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Sources for Wolff-Parkinson-White Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet