WPWS
MCID: WLF001
MIFTS: 56

Wolff-Parkinson-White Syndrome (WPWS) malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 54 12 50 24 25 66 29 13 52 42 14 69
Preexcitation Syndrome 50 24 69
Ventricular Familial Preexcitation Syndrome 50 66
Anomalous Atrioventricular Excitation 12 69
Wolff-Parkinson-White Pattern 12 29
Wpw Syndrome 50 25
Auriculoventricular Accessory Pathway Syndrome 50
Ventricular Pre-Excitation with Arrhythmia 25
Anomalous Ventricular Excitation Syndrome 50
False Bundle Branch Block Syndrome 50
Ventricular Preexcitation 69
Anomalous a-V Excitation 12
Wpws 66

Classifications:



External Ids:

OMIM 54 194200
Disease Ontology 12 DOID:384
ICD10 33 I45.6
ICD9CM 35 426.7
MeSH 42 D014927
NCIt 47 C35132

Summaries for Wolff-Parkinson-White Syndrome

NIH Rare Diseases : 50 wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards based summary : Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related and cardiomyopathy, hypertrophic 6, and has symptoms including sudden cardiac death, cardiomyopathy and stroke. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Vascular smooth muscle contraction and Angiopoietin Like Protein 8 Regulatory Pathway. Affiliated tissues include heart, testes and thyroid.

Genetics Home Reference : 25 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot : 66 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia : 71 Wolff–Parkinson–White syndrome (WPW) is a disorder due to a specific type of problem with the... more...

Description from OMIM: 194200

Related Diseases for Wolff-Parkinson-White Syndrome

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related 12.3
2 cardiomyopathy, hypertrophic 6 11.3
3 atrial fibrillation 10.9
4 myoclonic epilepsy associated with ragged-red fibers 10.9
5 cardiomyopathy 10.6
6 myocardial infarction 10.6
7 dilated cardiomyopathy 10.4
8 brugada syndrome 10.4
9 right bundle branch block 10.3
10 tuberous sclerosis 10.3
11 syncope 10.3
12 acute myocardial infarction 10.1
13 transposition of the great arteries 10.1
14 congestive heart failure 10.1
15 thyroiditis 10.1
16 sudden cardiac death 10.1
17 aneurysm 10.1
18 myocarditis 10.1
19 dextrocardia 10.1
20 muscular dystrophy 10.1
21 cardiac arrest 10.1
22 tricuspid atresia 10.1
23 rasa1-related disorders 10.1 PRKAA2 PRKAG2
24 pulmonary atresia with intact ventricular septum 10.0
25 adenoma 10.0
26 peripartum cardiomyopathy 10.0
27 cardiac sarcoidosis 10.0
28 spondylitis 10.0
29 leopard syndrome 10.0
30 hypogonadotropism 10.0
31 hemolytic anemia 10.0
32 epilepsy 10.0
33 cocaine abuse 10.0
34 schizophrenia 10.0
35 hypogonadism 10.0
36 mediastinitis 10.0
37 spinal cord injury 10.0
38 lutembacher's syndrome 10.0
39 encephalopathy 10.0
40 asthma 10.0
41 myotonia congenita 10.0
42 neuropathy 10.0
43 myotonia 10.0
44 leigh syndrome 10.0
45 familial atrial fibrillation 10.0
46 cervicitis 10.0
47 rubella 10.0
48 ischemia 10.0
49 pulmonary embolism 10.0
50 univentricular heart 10.0

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to Wolff-Parkinson-White Syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

32 (show all 10)
id Description HPO Frequency HPO Source Accession
1 sudden cardiac death 32 HP:0001645
2 cardiomyopathy 32 HP:0001638
3 wolff-parkinson-white syndrome 32 HP:0001716
4 stroke 32 HP:0001297
5 paroxysmal atrial fibrillation 32 HP:0004757
6 palpitations 32 HP:0001962
7 shortened pr interval 32 HP:0005165
8 paroxysmal supraventricular tachycardia 32 HP:0004763
9 prolonged qrs complex 32 HP:0006677
10 ventricular preexcitation with multiple accessory pathways 32 HP:0006684

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Interventional clinical trials:


id Name Status NCT ID Phase
1 Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Completed NCT00251121
2 Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory Duct Terminated NCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern 29
2 Wolff-Parkinson-White Syndrome 29 24 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

39
Heart, Testes, Thyroid, Placenta, Uterus, Spinal Cord, Atrioventricular Node

Publications for Wolff-Parkinson-White Syndrome

Articles related to Wolff-Parkinson-White Syndrome:

(show top 50) (show all 576)
id Title Authors Year
1
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. ( 28084962 )
2017
2
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. ( 28491758 )
2017
3
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. ( 27815796 )
2017
4
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. ( 28214246 )
2017
5
Tachyarrhythmia in Wolff-Parkinson-White Syndrome. ( 27429700 )
2016
6
The Wolff-Parkinson-White Syndrome: A Test Bed for the Assessment of Myocardial Dyssynchrony? ( 27307557 )
2016
7
Spontaneous Transition of Double Tachycardias with Atrial Fusion in a Patient with Wolff-Parkinson-White Syndrome. ( 27482269 )
2016
8
Noninvasive Localization of Accessory Pathways in Wolff-Parkinson-White Syndrome by Three-Dimensional Speckle Tracking Echocardiography. ( 27307551 )
2016
9
PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population. ( 27866917 )
2016
10
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. ( 27555124 )
2016
11
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. ( 26719390 )
2016
12
Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff-Parkinson-White syndrome: Uneven depression of accessory pathway conduction. ( 28491747 )
2016
13
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. ( 27042562 )
2016
14
Physiological Expression of AMPKI^2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice. ( 27621313 )
2016
15
Wolff-Parkinson-White Syndrome in a Term Infant Presenting With Cardiopulmonary Arrest. ( 26742096 )
2016
16
The impact of B-type natriuretic peptide levels on the suppression of accompanying atrial fibrillation in Wolff-Parkinson-White syndrome patients after accessory pathway ablation. ( 26917195 )
2016
17
Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading. ( 27869041 )
2016
18
Detecting Regional Myocardial Abnormalities in Patients With Wolff-Parkinson-White Syndrome With the Use of ECG-Gated Cardiac MDCT. ( 26866341 )
2016
19
Depression masquerading as chest pain in a patient with Wolff Parkinson White syndrome. ( 27738505 )
2016
20
Wolff-Parkinson-White syndrome with bundle branch and fascicular block: The diagnostic clue of electrocardiogram. ( 25497533 )
2015
21
Atrial fibrillation with Wolff-Parkinson-White syndrome in epilepsy: A potentially fatal combination. ( 26552553 )
2015
22
Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation. ( 26480930 )
2015
23
Atrial Fibrillation in a 35-Year-Old Man with Wolff-Parkinson-White Syndrome. ( 26504453 )
2015
24
A young patient with atypical type-B Wolff-Parkinson-White syndrome accompanied by left ventricular dysfunction. ( 26336525 )
2015
25
Treatment of Wolff-Parkinson-White Syndrome With a Thoracoscopic Surgical Procedure. ( 26140800 )
2015
26
Utility of Exercise Testing and Adenosine Response for Risk Assessment in Children with Wolff-Parkinson-White Syndrome. ( 26010236 )
2015
27
Variable primary phenotypic manifestations in a rare familial form of Wolff-Parkinson-White syndrome and hypertrophic cardiomyopathy. ( 26333379 )
2015
28
Response to letter regarding article, "Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients". ( 25986452 )
2015
29
Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. ( 26284702 )
2015
30
Extracorporeal life support for cardiac arrest in a 13-year-old girl caused by Wolff-Parkinson-White syndrome. ( 26314214 )
2015
31
Wolff-Parkinson-White syndrome: comprehensive electrophysiologic assessment with the help of a single PVC. ( 26120612 )
2015
32
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. ( 26256551 )
2015
33
Comparison of the accuracy of three algorithms in predicting accessory pathways among adult Wolff-Parkinson-White syndrome patients. ( 26384677 )
2015
34
Supraventricular Tachycardia Cardioverted by an Automated External Debrillator in a 9-year-old Male with a History of Wolff-Parkinson-White Syndrome. ( 25664915 )
2015
35
MY APPROACH to Wolff-Parkinson-White syndrome. ( 25592237 )
2015
36
Swallowing-induced atrial tachyarrhythmias successfully ablated at the left posterior interatrial septum in patient with wolff-Parkinson-white syndrome. ( 26023316 )
2015
37
50th anniversary landmark commentary on Sealy WC, Hattler BG Jr, Blumenschein SD, Cobb FR. Surgical treatment of Wolff-Parkinson-White syndrome. Ann Thorac Surg 1969;8:1-11. ( 25742810 )
2015
38
Thyroid storm in a patient with Wolff-Parkinson-White syndrome. ( 26670895 )
2015
39
Accessory conduction pathway ablated by myocarditis in a patient with Wolff-Parkinson-White syndrome. ( 26520696 )
2015
40
Letter by Fenici et al Regarding Articles, "Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation: Insights From a Registry Study of 2169 Patients" and "The Asymptomatic Wolff-Parkinson-White Patient: Time to be More Proactive?". ( 25986451 )
2015
41
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. ( 26361569 )
2015
42
Epidemiological profile of Wolff-Parkinson-White syndrome in a general population younger than 50 years of age in an era of radiofrequency catheter ablation. ( 24798784 )
2014
43
Wolff-Parkinson-White Syndrome in Congenital Rubella Syndrome. ( 24567174 )
2014
44
Wolff-Parkinson-White syndrome unmasked by atrial pacing in a patient with cardiac sarcoidosis. ( 24696224 )
2014
45
Marked septal dyskinesis from Wolff-Parkinson-White syndrome. ( 25446063 )
2014
46
Exercise testing in children with Wolff-Parkinson-White syndrome: what is its value? ( 24728424 )
2014
47
Wolff-Parkinson-White syndrome (WPW) and athletes: Darwin at play? ( 25722079 )
2014
48
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. ( 25269932 )
2014
49
Tachydysrhythmia treatment and adverse events in patients with wolff-Parkinson-white syndrome. ( 24880554 )
2014
50
Recurrence of accessory pathway after radiofrequency ablation from a benign to a malignant form of Wolff-Parkinson-White syndrome: a very uncommon case. ( 24692515 )
2014

Variations for Wolff-Parkinson-White Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

66
id Symbol AA change Variation ID SNP ID
1 PRKAG2 p.Arg302Gln VAR_013264 rs121908987
2 PRKAG2 p.Arg531Gly VAR_032909 rs121908990

ClinVar genetic disease variations for Wolff-Parkinson-White Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh37 Chromosome 7, 151273498: 151273498

Expression for Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for Wolff-Parkinson-White Syndrome

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 MYH7 PRKAA2 PRKAG2 PRKAG3
2
Show member pathways
12.29 PRKAA2 PRKAG2 PRKAG3
3 12.25 CBS PRKAA2 PRKAG2 PRKAG3
4
Show member pathways
12.24 BMP2 MYH7 NKX2-5
5
Show member pathways
12.21 PRKAA2 PRKAG2 PRKAG3
6
Show member pathways
12.19 PRKAA2 PRKAG2 PRKAG3
7
Show member pathways
12.01 PRKAA2 PRKAG2 PRKAG3
8 12 PRKAA2 PRKAG2 PRKAG3
9
Show member pathways
11.97 PRKAA2 PRKAG2 PRKAG3
10
Show member pathways
11.93 PRKAA2 PRKAG2 PRKAG3
11
Show member pathways
11.92 PRKAA2 PRKAG2 PRKAG3
12
Show member pathways
11.87 PRKAA2 PRKAG2 PRKAG3
13
Show member pathways
11.86 PRKAA2 PRKAG2 PRKAG3
14
Show member pathways
11.86 MYH7 PRKAA2 PRKAG2 PRKAG3
15
Show member pathways
11.75 PRKAA2 PRKAG2 PRKAG3
16 11.7 PRKAA2 PRKAG2 PRKAG3
17 11.6 PRKAA2 PRKAG2 PRKAG3
18 11.6 JAG1 PRKAA2 PRKAG2 PRKAG3
19 11.5 PRKAA2 PRKAG2 PRKAG3
20 11.45 PRKAA2 PRKAG2 PRKAG3
21 11.3 PRKAA2 PRKAG2 PRKAG3
22 11.29 BMP2 NKX2-5
23
Show member pathways
11.18 PRKAA2 PRKAG2 PRKAG3
24 10.99 PRKAA2 PRKAG2 PRKAG3
25 10.72 MYH7 PRKAA2 PRKAG2 PRKAG3
26 10.57 PRKAA2 PRKAG2
27 10.47 BMP2 MYH7 NKX2-5

GO Terms for Wolff-Parkinson-White Syndrome

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleotide-activated protein kinase complex GO:0031588 8.8 PRKAA2 PRKAG2 PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.83 BMP2 PRKAA2 PRKAG2 PRKAG3
2 fatty acid metabolic process GO:0006631 9.65 PRKAA2 PRKAG2 PRKAG3
3 cell cycle arrest GO:0007050 9.63 PRKAA2 PRKAG2 PRKAG3
4 regulation of signal transduction by p53 class mediator GO:1901796 9.61 PRKAA2 PRKAG2 PRKAG3
5 positive regulation of osteoblast differentiation GO:0045669 9.56 BMP2 JAG1
6 inner ear development GO:0048839 9.55 BMP2 JAG1
7 cardiac muscle contraction GO:0060048 9.54 MYH7 NKX2-5
8 sterol biosynthetic process GO:0016126 9.51 PRKAA2 PRKAG2
9 macroautophagy GO:0016236 9.5 PRKAA2 PRKAG2 PRKAG3
10 cardiac muscle cell differentiation GO:0055007 9.49 BMP2 NKX2-5
11 cardiac muscle tissue morphogenesis GO:0055008 9.4 BMP2 NKX2-5
12 adult heart development GO:0007512 9.37 MYH7 NKX2-5
13 carnitine shuttle GO:0006853 9.26 PRKAA2 PRKAG2
14 regulation of fatty acid biosynthetic process GO:0042304 9.16 PRKAA2 PRKAG2
15 fatty acid biosynthetic process GO:0006633 9.13 PRKAA2 PRKAG2 PRKAG3
16 regulation of macroautophagy GO:0016241 8.8 PRKAA2 PRKAG2 PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 AMP-activated protein kinase activity GO:0004679 8.8 PRKAA2 PRKAG2 PRKAG3

Sources for Wolff-Parkinson-White Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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