MCID: WLF001
MIFTS: 65

Wolff-Parkinson-White Syndrome malady

Cardiovascular diseases, Genetic diseases categories

Summaries for Wolff-Parkinson-White Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards: Wolff-Parkinson-White Syndrome, also known as wolff parkinson white syndrome, is related to hypertrophic cardiomyopathy and familial hypertrophic cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and AMPK inhibits chREBP transcriptional activation activity. The drugs adenosine and adenosine monophosphate and the compounds metformin hydrochloride and pt 1 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Genetics Home Reference:21 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:63 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the... more...

Description from OMIM:46 194200

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

wolff-parkinson-white syndrome 8 9 42 21 46 10 44 60
wolff parkinson white syndrome 8 20
wolff-parkinson-white pattern 8 22
auriculoventricular accessory pathway syndrome 42
ventricular familial preexcitation syndrome 42
ventricular pre-excitation with arrhythmia 21
anomalous ventricular excitation syndrome 42
false bundle branch block syndrome 42
parkinson disease, late-onset 60
pre-excitation syndromes 60
wolff-park-white syndr. 8
preexcitation syndrome 42
wpw syndrome 21


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Disease Ontology8 DOID:384
OMIM46 194200
NCIt39 C35132
MeSH34 D014927
ICD1025 I45.6

Related Diseases for Wolff-Parkinson-White Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic cardiomyopathy30.9MYH7, PRKAG2
2familial hypertrophic cardiomyopathy30.6MYH7
3glycogen storage disease30.4PRKAG2
4myocardial infarction10.9
5image syndrome10.9
6dilated cardiomyopathy10.7
7brugada syndrome10.7
8anomalous atrioventricular excitation10.7
9right bundle branch block10.6
10tuberous sclerosis10.5
11acute myocardial infarction10.5
12dextrocardia10.4
13inferior myocardial infarction10.4
14congestive heart failure10.4
15muscular dystrophy10.4
16familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related10.4
17parkinson disease, late-onset10.3
18sotos syndrome10.3
19atrioventricular block10.3
20lown-ganong-levine syndrome10.3
21leopard syndrome10.3
22ankylosing spondylitis10.3
23lutembacher's syndrome10.3
24coronary aneurysm10.3
25cerebritis10.3
26arrhythmogenic right ventricular dysplasia10.3
27danon disease10.3
28placenta accreta10.3
29melas syndrome10.3
30alagille syndrome10.3
31becker muscular dystrophy10.3
32duchenne muscular dystrophy10.3
33gestational diabetes10.3
34peripartum cardiomyopathy10.3
35familial atrial fibrillation10.3
36scimitar syndrome10.3
37cocaine abuse10.3
38hypogonadotropism10.3
39subacute bacterial endocarditis10.3
40adult syndrome10.3
41hypokalemic periodic paralysis10.3
42adenoma10.3
43asthma10.3
44cervicitis10.3
45coronary stenosis10.3
46endocarditis10.3
47hemolytic anemia10.3
48hypogonadism10.3
49ischemia10.3
50lactic acidosis10.3

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Clinical Features for Wolff-Parkinson-White Syndrome

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46OMIM
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Clinical features from OMIM:

194200

Clinical synopsis from OMIM:

194200

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Wolff-Parkinson-White Syndrome

Drug clinical trials:

Search ClinicalTrials for Wolff-Parkinson-White Syndrome

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Search CenterWatch for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Wolff-Parkinson-White Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Syndrome20 PRKAG2
2 Wolff-Parkinson-White Pattern22

Anatomical Context for Wolff-Parkinson-White Syndrome

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32MalaCards
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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

32
Heart, Testes, Spinal cord, Thyroid, Uterus, Placenta, Atrioventricular node

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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Publications for Wolff-Parkinson-White Syndrome

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50PubMed
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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Electroconvulsive therapy-induced Wolff-Parkinson-White syndrome: a case report. (23517819)
2013
2
Dyssynchronous ventricular contraction in Wolff-Parkinson-White syndrome: a risk factor for the development of dilated cardiomyopathy. (23812508)
2013
3
Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome. (23239491)
2013
4
Current strategy for treatment of patients with Wolff-Parkinson-White syndrome and asymptomatic preexcitation in Europe: European Heart Rhythm Association survey. (23625944)
2013
5
Transesophageal evaluation of asymptomatic Wolff-Parkinson-White syndrome. (22360708)
2012
6
Risk stratification in Wolff-Parkinson-White syndrome: the correlation between noninvasive and invasive testing in pediatric patients. (22978820)
2012
7
Recurrent delirium caused by concealed Wolff-Parkinson-White syndrome in a 77 year old woman. (22353837)
2012
8
The impact of age on the electrophysiological characteristics and different arrhythmia patterns in patients with Wolff-Parkinson-White syndrome. (21040092)
2011
9
Ventricular ectopy following successful cryoablation for Wolff-Parkinson-White syndrome in the right posterior septum: a case report. (21106023)
2010
10
Chaotic atrial tachycardia-related ventricular fibrillation in a 2-month-old baby with Wolff-Parkinson-White syndrome. (20199710)
2010
11
Safety and efficacy of flecainide in the treatment of symptomatic children with Wolff-Parkinson-White syndrome. (20717658)
2010
12
Contributions of the Instituto Nacional de CardiologA-a in the diagnosis and treatment of the Wolff-Parkinson - White syndrome. (21169099)
2010
13
Amiodarone-induced torsade de pointes in a patient with wolff-Parkinson-White syndrome. (19465366)
2009
14
20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. (18812404)
2009
15
When should we recommend catheter ablation for patients with the Wolff-Parkinson-White syndrome? (18281825)
2008
16
Percutenous catheter ablation of the accessory pathway in a patient with wolff-Parkinson-white syndrome associated with familial atrial fibrillation. (18379660)
2008
17
Effects of radiofrequency catheter ablation on myocardial performance index and plasma NT-Pro-BNP levels in patients with Wolff-Parkinson-White syndrome. (18422672)
2008
18
Noninvasive electrocardiographic imaging (ECGI) of a univentricular heart with Wolff-Parkinson-White syndrome. (18325851)
2008
19
Systemic sclerosis sine scleroderma associated with Wolff-Parkinson-White syndrome. (17454939)
2007
20
Evidence-based case report for analgesic and anesthetic management of a parturient with Ebstein's Anomaly and Wolff-Parkinson-White syndrome. (17125999)
2007
21
Wolff-Parkinson-White syndrome in athletes. (16934207)
2006
22
Atrial fibrillation triggered by postinfarction ventricular premature beats in a patient with Wolff-Parkinson-White syndrome. (15878558)
2005
23
False-positive exercise test secondary to Wolff-Parkinson-White syndrome in the absence of manifest preexcitation and disappearance of ST depressions after accessory pathway ablation. (15655280)
2004
24
Early repolarization pattern occurring with the wolff-Parkinson-white syndrome. (14514562)
2003
25
Idiopathic ventricular fibrillation in a patient with Wolff-Parkinson-White syndrome. (12227703)
2002
26
Identification of mtDNA mutation in a pedigree with gestational diabetes, deafness, Wolff-Parkinson-White syndrome and placenta accreta. (11096278)
2001
27
Wolff-Parkinson-White syndrome mimicking acute anterior myocardial infarction in a young male patient--a case report. (11330514)
2001
28
Images in cardiology. Wolff-Parkinson-White syndrome associated with a coronary sinus diverticulum. (10761811)
2000
29
S1 in Wolff-Parkinson-White syndrome. (10939982)
2000
30
Decreased amplitude of left ventricular posterior wall motion with notch movement to determine the left posterior septal accessory pathway in Wolff-Parkinson-White syndrome. (10573503)
1999
31
Improved cardiac function after catheter ablation in a patient with type B Wolff-Parkinson-White syndrome with an old myocardial infarction. (9856605)
1998
32
Dependency on atrial electrophysiological properties of appearance of paroxysmal atrial fibrillation in patients with Wolff-Parkinson-White syndrome: evidence from atrial vulnerability before and after radiofrequency catheter ablation and surgical cryoablation. (9507546)
1998
33
Retrograde multiple and multifiber accessory pathway conduction in the Wolff-Parkinson-White syndrome: potential precipitating factor of atrial fibrillation. (9511888)
1998
34
Outpatient anesthetic management of a patient with Wolff-Parkinson-White syndrome. (9024357)
1997
35
Augmented sympathoadrenal activity during treadmill exercise in patients with Wolff-Parkinson-White syndrome and atrial fibrillation. (8648883)
1996
36
Paradox of accessory pathway block after radiofrequency ablation in patients with the Wolff-Parkinson-White syndrome. (8921755)
1996
37
Aborted sudden death in the Wolff-Parkinson-White syndrome. (7653450)
1995
38
Effect of almokalant, a selective potassium channel blocker, on the termination and inducibility of paroxysmal supraventricular tachycardias: a study in patients with Wolff-Parkinson-White syndrome and atrioventricular nodal reentrant tachycardia. Almokalant PSVT Study Group. (7475043)
1995
39
Catheter ablation of the accessory pathways of the Wolff-Parkinson-White syndrome and its variants. (7871178)
1995
40
Magnesium reversal of digoxin-facilitated ventricular rate during atrial fibrillation in the Wolff-Parkinson-White syndrome. (8030653)
1994
41
Memory T waves after radiofrequency catheter ablation of accessory atrioventricular connections in Wolff-Parkinson-White syndrome. (7930987)
1994
42
Analysis of re-entry mechanism in a patient with concealed Wolff-Parkinson-White syndrome. (7638041)
1994
43
Inducible ventricular tachyarrhythmia in children with Wolff-Parkinson-White syndrome. (7509122)
1994
44
Use of biplane transesophageal echocardiographic guide in radiofrequency catheter ablation of Wolff-Parkinson-White syndrome with left side Kent bundle. (8355401)
1993
45
A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953-1989. (8443907)
1993
46
Coexisting Wolff-Parkinson-White syndrome and cardiac valve disease: a staged treatment approach with catheter ablation before operation. (8246575)
1993
47
Flecainide in the Wolff-Parkinson-White syndrome. (1509995)
1992
48
Surgically created Wolff-Parkinson-White syndrome after Fontan operation. (1384449)
1992
49
Anesthetic management of labor in a patient with dextrocardia, congenitally corrected transposition, Wolff-Parkinson-White syndrome, and congestive heart failure. (2801815)
1989
50
Wolff-Parkinson-White syndrome type B with tachycardia-dependent (phase 3) block in the accessory pathway and in left bundle-branch coexisting with rate-unrelated right bundle-branch block. (7397051)
1980

Genetic Variations for Wolff-Parkinson-White Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Wolff-Parkinson-White Syndrome:

62
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.9PRKAA2, PRKAG2
39.6NKX2-5, BMP2
49.6PRKAA1, PRKAA2
5
Hide members
9.5PRKAG2, PRKAA2, PRKAG3
6
Hide members
9.2MYH7, NKX2-5, BMP2
79.2MYH7, NKX2-5, BMP2
89.0BMP2, PRKAA2, PRKAA1
98.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
10
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
11
Translation Insulin regulation of translation
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
128.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
13
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
148.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
15
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
168.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
17
Development Leptin signaling via PI3K-dependent pathway
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
188.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
198.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
208.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
21
Hide members
8.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2
22
Hide members
8.3BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1
23
Hide members
8.0AP2A2, MT-ND5, PRKAG2, PRKAA2, PRKAG3, PRKAA1
24
Hide members
7.9BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1, MYH7
25
Hide members
7.4AP2A2, BMP2, JAG1, PRKAG2, PRKAA2, PRKAG3

Compounds for genes affiliated with Wolff-Parkinson-White Syndrome

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1metformin hydrochloride599.8PRKAA2, PRKAA1
2pt 1599.8PRKAA2, PRKAA1
3a 769662599.8PRKAA2, PRKAA1
4dorsomorphin dihydrochloride599.8PRKAA2, PRKAA1
5phenformin44 1110.7PRKAA1, PRKAA2
6acadesine449.6PRKAA2, PRKAA1
7phosphocreatine44 2410.4MYH7, PRKAA1, PRKAA2
8aicar44 11 2411.3PRKAA2, PRKAA1
9rapamycin449.0PRKAA1, PRKAA2, BMP2
10nitric oxide44 11 2410.5BMP2, JAG1, PRKAA2, PRKAA1, NKX2-5
11creatinine448.5MYH7, PRKAA1, PRKAA2, BMP2
12threonine448.4BMP2, MT-ND5, PRKAA2, PRKAA1, MYH7
13serine448.0MYH7, NKX2-5, PRKAA1, PRKAA2, MT-ND5, BMP2

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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16Gene Ontology
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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315889.2PRKAA1, PRKAG3, PRKAG2

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:04230410.2PRKAG2, PRKAA2
2carnitine shuttleGO:00685310.1PRKAG2, PRKAA2
3regulation of energy homeostasisGO:20005059.9PRKAA1, PRKAA2
4regulation of circadian rhythmGO:0427529.8PRKAA1, PRKAA2
5fatty acid homeostasisGO:0550899.8PRKAA2, PRKAA1
6cardiac muscle tissue morphogenesisGO:0550089.8BMP2, NKX2-5
7cellular response to nutrient levelsGO:0316699.8PRKAA2, PRKAA1
8adult heart developmentGO:0075129.8NKX2-5, MYH7
9positive regulation of glycolysisGO:0458219.8PRKAA1, PRKAA2
10lipid biosynthetic processGO:0086109.7PRKAA2, PRKAA1
11cellular response to glucose starvationGO:0421499.7PRKAA1, PRKAA2
12rhythmic processGO:0485119.6PRKAA1, PRKAA2
13positive regulation of autophagyGO:0105089.6PRKAA1, PRKAA2
14cholesterol biosynthetic processGO:0066959.6PRKAA1, PRKAA2
15negative regulation of TOR signaling cascadeGO:0320079.5PRKAA2, PRKAA1
16cardiac muscle cell differentiationGO:0550079.3NKX2-5, BMP2
17fatty acid biosynthetic processGO:0066339.2PRKAA1, PRKAG3, PRKAA2, PRKAG2
18cell cycle arrestGO:0070509.2PRKAG2, PRKAA2, PRKAG3, PRKAA1
19insulin receptor signaling pathwayGO:0082869.2PRKAG2, PRKAA2, PRKAG3, PRKAA1

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityGO:0473229.6PRKAA1, PRKAA2
2[acetyl-CoA carboxylase] kinase activityGO:0504059.5PRKAA1, PRKAA2
3histone serine kinase activityGO:0351749.3PRKAA2, PRKAA1
4AMP-activated protein kinase activityGO:0046799.2PRKAA1, PRKAG3, PRKAA2
5ATP bindingGO:0055248.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2

Products for genes affiliated with Wolff-Parkinson-White Syndrome

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Sources for Wolff-Parkinson-White Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet