MCID: WLF001
MIFTS: 57

Wolff-Parkinson-White Syndrome malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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Aliases & Descriptions for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 49 10 11 45 22 23 47 12 67 36 65
Preexcitation Syndrome 45 22 65
Ventricular Familial Preexcitation Syndrome 45 67
Anomalous Atrioventricular Excitation 10 65
Wolff-Parkinson-White Pattern 10 24
Wpw Syndrome 45 23
Auriculoventricular Accessory Pathway Syndrome 45
 
Ventricular Pre-Excitation with Arrhythmia 23
Anomalous Ventricular Excitation Syndrome 45
False Bundle Branch Block Syndrome 45
Ventricular Preexcitation 65
Anomalous a-V Excitation 10
Wpws 67

Classifications:



External Ids:

OMIM49 194200
Disease Ontology10 DOID:384
ICD1027 I45.6
ICD9CM29 426.7
MeSH36 D014927
NCIt42 C35132
UMLS65 C0043202, C0392470, C0032915 C0559106, more

Summaries for Wolff-Parkinson-White Syndrome

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NIH Rare Diseases:45 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as preexcitation syndrome, is related to leopard syndrome and cardiomyopathy, hypertrophic 6, and has symptoms including arrhythmia, ventricular preexcitation with multiple accessory pathways and prolonged qrs complex. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and Heart Development. The drugs adenosine and adenosine monophosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain.

UniProtKB/Swiss-Prot:67 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Genetics Home Reference:23 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:68 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the... more...

Description from OMIM:49 194200

Related Diseases for Wolff-Parkinson-White Syndrome

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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1leopard syndrome30.0MYH7, NKX2-5
2cardiomyopathy, hypertrophic 627.4BMP2, JAG1, MT-CYB, MT-ND5, MYH7, NKX2-5
3familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related12.4
4atrial fibrillation11.0
5cardiomyopathy10.8
6myocardial infarction10.7
7dilated cardiomyopathy10.5
8hypertrophic cardiomyopathy10.5
9brugada syndrome10.5
10right bundle branch block10.4
11tuberous sclerosis10.4
12syncope10.4
13polycystic kidney disease, autosomal dominant10.4PRKAA2, PRKAG2
14lown-ganong-levine syndrome10.4
15acute myocardial infarction10.3
16congestive heart failure10.3
17cardiac arrest10.3
18thyroiditis10.3
19myocarditis10.3
20dextrocardia10.3
21muscular dystrophy10.3
22transposition of the great arteries10.3
23tricuspid atresia10.3
24sudden cardiac death10.3
25aneurysm10.3
26schizophrenia10.1
27asthma10.1
28leigh syndrome10.1
29danon disease10.1
30alagille syndrome10.1
31duchenne muscular dystrophy10.1
32becker muscular dystrophy10.1
33hemolytic anemia10.1
34spinal cord injury10.1
35familial atrial fibrillation10.1
36endocarditis10.1
37heart disease10.1
38gestational diabetes10.1
39cardiac sarcoidosis10.1
40hypogonadism10.1
41lutembacher's syndrome10.1
42myotonia congenita10.1
43cervicitis10.1
44ischemia10.1
45cerebritis10.1
46lactic acidosis10.1
47subacute bacterial endocarditis10.1
48placenta accreta10.1
49pneumonia10.1
50inferior myocardial infarction10.1

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Intermediate Coronary SyndromeIschemic Heart Disease
Mitral Valve DiseaseFamilial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Symptoms for Wolff-Parkinson-White Syndrome

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Symptoms by clinical synopsis from OMIM:

194200

Clinical features from OMIM:

194200

HPO human phenotypes related to Wolff-Parkinson-White Syndrome:

(show all 11)
id Description Frequency HPO Source Accession
1 arrhythmia hallmark (90%) HP:0011675
2 ventricular preexcitation with multiple accessory pathways HP:0006684
3 prolonged qrs complex HP:0006677
4 shortened pr interval HP:0005165
5 paroxysmal supraventricular tachycardia HP:0004763
6 paroxysmal atrial fibrillation HP:0004757
7 palpitations HP:0001962
8 wolff-parkinson-white syndrome HP:0001716
9 sudden cardiac death HP:0001645
10 cardiomyopathy HP:0001638
11 stroke HP:0001297

UMLS symptoms related to Wolff-Parkinson-White Syndrome:


fetal bradycardia, fetal tachycardia

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECGCompletedNCT00251121
2Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory DuctTerminatedNCT00873470

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Syndrome22 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

33
Heart, Kidney, Brain, Thyroid, Testes, B cells, Liver

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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Publications for Wolff-Parkinson-White Syndrome

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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. (26719390)
2016
2
Ventricular fibrillation development following atrial fibrillation after the ingestion of sildenaphil in a patient with Wolff-Parkinson-White syndrome. (26361569)
2015
3
How to maintain the oral health of a child with Wolff-Parkinson-White syndrome: a case report. (25269932)
2014
4
Multiple cardiac rhabdomyomas, wolff-Parkinson-white syndrome, and tuberous sclerosis: an infrequent combination. (25328743)
2014
5
LEOPARD syndrome with Wolff-Parkinson-White syndrome on electrocardiography. (24177621)
2013
6
Malignant arrhythmia as the first manifestation of Wolff-Parkinson-White syndrome: a case with minimal preexcitation on electrocardiography. (24831910)
2013
7
Anesthesia for Wolff-Parkinson-White syndrome: A report of two cases. (24015147)
2013
8
Electroconvulsive therapy-induced Wolff-Parkinson-White syndrome: a case report. (23517819)
2013
9
Deterioration of QT prolongation after successful catheter ablation for Wolff-Parkinson-White syndrome. (22087028)
2012
10
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
11
Transesophageal evaluation of asymptomatic Wolff-Parkinson-White syndrome. (22360708)
2012
12
Novel method of signal analysis for ablation of Wolff-Parkinson-White syndrome. (21872561)
2012
13
Computed tomography of a coronary sinus diverticulum associated with Wolff-Parkinson-White syndrome. (21699845)
2012
14
Accuracy of algorithms to predict accessory pathway location in children with Wolff-Parkinson-White syndrome. (21917661)
2012
15
Becker myotonia congenita associated with Wolff-Parkinson-White syndrome. (21192192)
2011
16
Septal dyskinesia and global left ventricular dysfunction in pediatric Wolff-Parkinson-White syndrome with septal accessory pathway. (19804548)
2010
17
Treadmill exercise test in Wolff-Parkinson-White syndrome. (20641113)
2010
18
ECG Diagnosis: Wolff-Parkinson-White Syndrome. (20740119)
2010
19
Wolff-Parkinson-White syndrome associated with Brugada syndrome. (19513016)
2009
20
Amiodarone-induced torsade de pointes in a patient with wolff-Parkinson-White syndrome. (19465366)
2009
21
Management of asymptomatic Wolff-Parkinson-White syndrome. (19752209)
2009
22
Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. (17292982)
2008
23
Wolff-Parkinson-White syndrome with an unroofed coronary sinus without persistent left superior vena cava treated with catheter cryoablation. (18679525)
2008
24
Aborted sudden cardiac death revealing isolated noncompaction of the left ventricle in a patient with wolff-Parkinson-white syndrome. (17367369)
2007
25
Wolff-Parkinson-White syndrome in Patients With MELAS. (17998445)
2007
26
Wolff-Parkinson-White syndrome in athletes. (16934207)
2006
27
History of Wolff-Parkinson-White syndrome: introductory note to a classic article by Louis Wolff, MD, John Parkinson, MD, and Paul D White, MD. (17040282)
2006
28
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? (16686673)
2006
29
Wolff-Parkinson-white syndrome in d-transposition of the great arteries and mustard baffle. (16818221)
2006
30
Olanzapine-induced QTc prolongation in a patient with Wolff-Parkinson-White syndrome. (15061254)
2004
31
Mitochondrial hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome. (15340680)
2004
32
Molecular genetic analysis of PRKAG2 in sporadic Wolff-Parkinson-White syndrome. (12716108)
2003
33
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. (12782567)
2003
34
Non-invasive diagnosis of concealed Wolff-Parkinson-White syndrome by detection of concealed anterograde pre-excitation. (11348037)
2001
35
An unusual electrocardiographic pattern in a patient with Wolff-Parkinson-White syndrome. (10962757)
2000
36
Reciprocating tachycardia during central venous cannulation in a patient with Wolff-Parkinson-White syndrome. (10786754)
2000
37
Decreased amplitude of left ventricular posterior wall motion with notch movement to determine the left posterior septal accessory pathway in Wolff-Parkinson-White syndrome. (10573503)
1999
38
Anaesthetic considerations in a patient with wolff-Parkinson-white syndrome. (17846481)
1999
39
Tachyarrhythmias in Wolff-Parkinson-White syndrome diagnosis and management. (11273256)
1998
40
Improved cardiac function after catheter ablation in a patient with type B Wolff-Parkinson-White syndrome with an old myocardial infarction. (9856605)
1998
41
The use of body surface potential map for identifying sites of accessory pathway in patients with Wolff-Parkinson-White syndrome. (9810295)
1998
42
False-positive 201thallium study in Wolff-Parkinson-White syndrome. (8640596)
1996
43
Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome progressing to ventricular dilation. (8644606)
1996
44
Body surface potential mapping of a patient with Wolff-Parkinson-White syndrome with two accessory pathways and two atrial pacemaker complexes. (8728600)
1996
45
Surgical cure of the Wolff-Parkinson-White syndrome--a comparison of two techniques. (7974042)
1994
46
Radiofrequency catheter ablation of atrioventricular accessory pathways in Wolff-Parkinson-White syndrome with drug-refractory and symptomatic supraventricular tachycardia--its high effectiveness irrespective of accessory pathway location and properties. (7966998)
1994
47
Radiofrequency catheter ablation for Wolff-Parkinson White syndrome. Part 2: Preventing complications. (7882861)
1994
48
Gated blood pool SPECT and phase analysis to assess simulated Wolff-Parkinson-White syndrome in the baboon. (8233841)
1993
49
Body surface distribution of abnormally low QRST areas in patients with Wolff-Parkinson-White syndrome. Evidence for continuation of repolarization abnormalities before and after catheter ablation. (8252678)
1993
50
Effects of flecainide on atrial electrophysiology in the Wolff-Parkinson-White syndrome. (1509996)
1992

Variations for Wolff-Parkinson-White Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

67
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Clinvar genetic disease variations for Wolff-Parkinson-White Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRKAG2NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)single nucleotide variantPathogenicrs121908987GRCh37Chr 7, 151273498: 151273498

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.8PRKAA2, PRKAG2
29.4BMP2, NKX2-5
3
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
4
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
5
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
6
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
7
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
8
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
99.0PRKAA2, PRKAG2, PRKAG3
109.0PRKAA2, PRKAG2, PRKAG3
11
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
129.0PRKAA2, PRKAG2, PRKAG3
13
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
149.0PRKAA2, PRKAG2, PRKAG3
15
Show member pathways
9.0PRKAA2, PRKAG2, PRKAG3
169.0PRKAA2, PRKAG2, PRKAG3
178.9BMP2, MYH7, NKX2-5
18
Show member pathways
8.9BMP2, MYH7, NKX2-5
198.5MYH7, PRKAA2, PRKAG2, PRKAG3
20
Show member pathways
8.5MYH7, PRKAA2, PRKAG2, PRKAG3
21
Show member pathways
8.5MYH7, PRKAA2, PRKAG2, PRKAG3
22
Show member pathways
8.5MT-CYB, PRKAA2, PRKAG2, PRKAG3

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:004230410.5PRKAA2, PRKAG2
2energy reserve metabolic processGO:000611210.1PRKAA2, PRKAG2
3positive regulation of osteoblast differentiationGO:004566910.0BMP2, JAG1
4cardiac muscle cell differentiationGO:00550079.9BMP2, NKX2-5
5cardiac muscle tissue morphogenesisGO:00550089.9BMP2, NKX2-5
6mitochondrion organizationGO:00070059.8PRKAA2, PRKAG3
7BMP signaling pathwayGO:00305099.8BMP2, NKX2-5
8macroautophagyGO:00162369.7PRKAA2, PRKAG3
9cell cycle arrestGO:00070509.5PRKAA2, PRKAG2, PRKAG3
10regulation of signal transduction by p53 class mediatorGO:19017969.4PRKAA2, PRKAG2, PRKAG3
11transcription initiation from RNA polymerase II promoterGO:00063679.1PRKAA2, PRKAG2, PRKAG3
12membrane organizationGO:00610249.0PRKAA2, PRKAG2, PRKAG3
13insulin receptor signaling pathwayGO:00082868.9PRKAA2, PRKAG2, PRKAG3
14organelle organizationGO:00069968.7PRKAA2, PRKAG2, PRKAG3
15protein phosphorylationGO:00064688.5BMP2, PRKAA2, PRKAG2, PRKAG3

Sources for Wolff-Parkinson-White Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet