MCID: WLF001
MIFTS: 65

Wolff-Parkinson-White Syndrome malady

Cardiovascular diseases, Genetic diseases categories

Summaries for Wolff-Parkinson-White Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.  last updated: 12/31/2012

MalaCards: Wolff-Parkinson-White Syndrome, also known as wolff parkinson white syndrome, is related to hypertrophic cardiomyopathy and familial hypertrophic cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit), and among its related pathways are Import of palmitoyl-CoA into the mitochondrial matrix and AMPK inhibits chREBP transcriptional activation activity. The drugs adenosine and adenosine monophosphate and the compounds metformin hydrochloride and pt 1 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Genetics Home Reference:21 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:63 Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the... more...

Description from OMIM:46 194200

Aliases & Classifications for Wolff-Parkinson-White Syndrome

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

wolff-parkinson-white syndrome 8 9 42 21 46 10 44 60
wolff parkinson white syndrome 8 20
wolff-parkinson-white pattern 8 22
auriculoventricular accessory pathway syndrome 42
ventricular familial preexcitation syndrome 42
ventricular pre-excitation with arrhythmia 21
anomalous ventricular excitation syndrome 42
false bundle branch block syndrome 42
parkinson disease, late-onset 60
pre-excitation syndromes 60
wolff-park-white syndr. 8
preexcitation syndrome 42
wpw syndrome 21


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Disease Ontology8 DOID:384
OMIM46 194200
NCIt39 C35132
MeSH34 D014927
ICD1025 I45.6

Related Diseases for Wolff-Parkinson-White Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic cardiomyopathy30.9MYH7, PRKAG2
2familial hypertrophic cardiomyopathy30.6MYH7
3glycogen storage disease30.4PRKAG2
4myocardial infarction10.9
5image syndrome10.9
6dilated cardiomyopathy10.7
7brugada syndrome10.7
8anomalous atrioventricular excitation10.7
9right bundle branch block10.6
10tuberous sclerosis10.5
11acute myocardial infarction10.5
12dextrocardia10.4
13inferior myocardial infarction10.4
14congestive heart failure10.4
15muscular dystrophy10.4
16familial hypertrophic cardiomyopathy with wolff-parkinson-white syndrome, prkag2-related10.4
17parkinson disease, late-onset10.3
18sotos syndrome10.3
19atrioventricular block10.3
20lown-ganong-levine syndrome10.3
21leopard syndrome10.3
22ankylosing spondylitis10.3
23lutembacher's syndrome10.3
24coronary aneurysm10.3
25cerebritis10.3
26arrhythmogenic right ventricular dysplasia10.3
27danon disease10.3
28placenta accreta10.3
29melas syndrome10.3
30alagille syndrome10.3
31becker muscular dystrophy10.3
32duchenne muscular dystrophy10.3
33gestational diabetes10.3
34peripartum cardiomyopathy10.3
35familial atrial fibrillation10.3
36scimitar syndrome10.3
37cocaine abuse10.3
38hypogonadotropism10.3
39subacute bacterial endocarditis10.3
40adult syndrome10.3
41hypokalemic periodic paralysis10.3
42adenoma10.3
43asthma10.3
44cervicitis10.3
45coronary stenosis10.3
46endocarditis10.3
47hemolytic anemia10.3
48hypogonadism10.3
49ischemia10.3
50lactic acidosis10.3

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to wolff-parkinson-white syndrome

Clinical Features for Wolff-Parkinson-White Syndrome

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46OMIM
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Clinical features from OMIM:

194200

Clinical synopsis from OMIM:

194200

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Wolff-Parkinson-White Syndrome

Drug clinical trials:

Search ClinicalTrials for Wolff-Parkinson-White Syndrome

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Search CenterWatch for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Wolff-Parkinson-White Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Wolff-Parkinson-White Syndrome:

id Genetic test Affiliating Genes
1 Wolff-Parkinson-White Syndrome20 PRKAG2
2 Wolff-Parkinson-White Pattern22

Anatomical Context for Wolff-Parkinson-White Syndrome

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32MalaCards
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MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

32
Heart, Testes, Spinal cord, Thyroid, Uterus, Placenta, Atrioventricular node

Animal Models for Wolff-Parkinson-White Syndrome or affiliated genes

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Publications for Wolff-Parkinson-White Syndrome

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50PubMed
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Articles related to Wolff-Parkinson-White Syndrome:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Atrial fibrillation in patient with concealed Wolff-Parkinson-White syndrome. (24297723)
2013
2
Amiodarone and catheter ablation as cardiac resynchronization therapy for children with dilated cardiomyopathy and wolff-Parkinson-white syndrome. (23407697)
2013
3
Restored cardiac function after successful resynchronization by right anterior and anteroseptal accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. (23031287)
2013
4
Deterioration of QT prolongation after successful catheter ablation for Wolff-Parkinson-White syndrome. (22087028)
2012
5
Non-contact mapping system accurately localizes right-sided accessory pathways in type B Wolff-Parkinson-White syndrome. (22135318)
2012
6
Atrial fibrillation in patients with Wolff-Parkinson-White syndrome: role of pulmonary veins. (22035173)
2012
7
Wolff-Parkinson-white syndrome in a patient with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes syndrome. (22194764)
2011
8
Detection and quantification by deformation imaging of the functional impact of septal compared to free wall preexcitation in the Wolff-Parkinson-White syndrome. (20691313)
2010
9
Evaluation of atrial vulnerability immediately after radiofrequency catheter ablation of accessory pathway in patients with Wolff-Parkinson-White syndrome. (19844784)
2009
10
Catecholamine challenge unmasking high-risk features in the Wolff-Parkinson-White syndrome. (19654129)
2009
11
Wolff-Parkinson-White syndrome with an unroofed coronary sinus without persistent left superior vena cava treated with catheter cryoablation. (18679525)
2008
12
Radiofrequency catheter ablation in a child with Wolff-Parkinson-White syndrome and congenitally corrected transposition of the great arteries. (18651511)
2007
13
Giant right atrial diverticulum associated with Wolff-Parkinson-White syndrome. (16643372)
2006
14
Use of medications in Wolff-Parkinson-White syndrome. (15952923)
2005
15
Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural history. (15766830)
2005
16
Exercise testing in Wolff-Parkinson-White syndrome: case report with ECG and literature review. (15821231)
2005
17
A simple and accurate method to identify early ventricular contraction sites in Wolff-Parkinson-White syndrome using high frame-rate tissue-velocity imaging. (12943891)
2003
18
Patient with Sotos syndrome, Wolff-Parkinson-White pattern on electrocardiogram, and two right-sided accessory bypass tracts. (12522794)
2003
19
Atrial fibrillation in patients with Wolff-Parkinson-White syndrome. (11942587)
2002
20
Proximal trisomy of 1q mosaicism in a girl with hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome and multiple congenital anomalies. (11343316)
2001
21
The natural history of Wolff-Parkinson-White syndrome in 228 military aviators: a long-term follow-up of 22 years. (11526369)
2001
22
Wolff-Parkinson-White syndrome associated with Brugada syndrome. (11584469)
2001
23
Accessory pathway associated with an anomalous coronary vein in a patient with Wolff-Parkinson-White syndrome. (11573701)
2001
24
An unusual electrocardiographic pattern in a patient with Wolff-Parkinson-White syndrome. (10962757)
2000
25
A case of normalization of Wolff-Parkinson-White syndrome conduction during propofol anesthesia. (10360880)
1999
26
Prediction of accessory pathway locations in Wolff-Parkinson-White syndrome with body surface potential Laplacian maps . A simulation study. (10611910)
1999
27
Electrocardiography in the patient with the Wolff-Parkinson-White syndrome: diagnostic and initial therapeutic issues. (10597097)
1999
28
Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia. (9915313)
1999
29
Detection of the earliest ventricular contraction site in patients with Wolff-Parkinson-White syndrome using two-dimensional guided M-mode tissue Doppler echocardiography. (10754350)
1999
30
Tachyarrhythmias in Wolff-Parkinson-White syndrome diagnosis and management. (11273256)
1998
31
Reproducibility of bipolar endocavitary electrogram measurements at sites of radiofrequency energy delivery in patients with the Wolff-Parkinson-White syndrome. (10027125)
1998
32
Utility of full electrophysiological study before accessory pathway ablation in Wolff-Parkinson-White syndrome. (9141967)
1997
33
Accessory atrioventricular pathways with only antegrade conduction in patients with symptomatic Wolff-Parkinson-White syndrome. Clinical features, electrophysiological characteristics and response to radiofrequency catheter ablation. (9049525)
1997
34
Therapy of Wolff-Parkinson-White syndrome. (8856468)
1996
35
Cerebral infarction in Wolff-Parkinson-White syndrome. (9251408)
1996
36
Myocarditis-associated ventricular fibrillation. An unusual cause of syncope in Wolff-Parkinson-White syndrome. (8605437)
1995
37
Propofol has no direct effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia. (7717560)
1995
38
Age- and anesthesia-related changes in accessory pathway conduction in children with Wolff-Parkinson-White syndrome. (7484867)
1995
39
Surgical treatment of Wolff-Parkinson-White syndrome: a "retrospectroscopic" view. (7944801)
1994
40
Risk of sudden arrhythmic death in the Wolff-Parkinson-White syndrome: current perspectives. (7517532)
1994
41
Should radiofrequency current ablation be performed in asymptomatic patients with the Wolff-Parkinson-White syndrome? (7681970)
1993
42
Biplanar transesophageal echocardiographic direction of radiofrequency catheter ablation in children and adolescents with the Wolff-Parkinson-White syndrome. (8456773)
1993
43
Results of a comparative study of low energy direct current with radiofrequency ablation in patients with the Wolff-Parkinson-White syndrome. (8280531)
1993
44
Surgical treatment of the Wolff-Parkinson-White syndrome--experiences in 120 patients. (8223764)
1993
45
Effects of flecainide on atrial electrophysiology in the Wolff-Parkinson-White syndrome. (1509996)
1992
46
Alfentanil-midazolam anaesthesia has no electrophysiological effects upon the normal conduction system or accessory pathways in patients with Wolff-Parkinson-White syndrome. (1288908)
1992
47
Reappraisal of intermediate-term follow-up of radiofrequency ablation of accessory atrioventricular pathways for treatment of Wolff-Parkinson-White syndrome. (1299741)
1992
48
Improved detection of accessory pathways that bridge posterior septal and left posterior regions in the Wolff-Parkinson-White syndrome. (1626508)
1992
49
Right atrial diverticulum presenting as Wolff-Parkinson-White syndrome. (1381075)
1992
50
Anomalous atrioventricular excitation (Wolff-Parkinson-White syndrome). (13619016)
1959

Genetic Variations for Wolff-Parkinson-White Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Wolff-Parkinson-White Syndrome:

62
id Symbol AA change Variation ID SNP ID
1PRKAG2p.Arg302GlnVAR_013264
2PRKAG2p.Arg531GlyVAR_032909

Expression for genes affiliated with Wolff-Parkinson-White Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for genes affiliated with Wolff-Parkinson-White Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PRKAA2, PRKAG2
29.9PRKAA2, PRKAG2
39.6NKX2-5, BMP2
49.6PRKAA1, PRKAA2
5
Hide members
9.5PRKAG2, PRKAA2, PRKAG3
6
Hide members
9.2MYH7, NKX2-5, BMP2
79.2MYH7, NKX2-5, BMP2
89.0BMP2, PRKAA2, PRKAA1
98.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
10
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
11
Translation Insulin regulation of translation
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
128.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
13
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
148.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
15
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
168.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
17
Development Leptin signaling via PI3K-dependent pathway
Hide members
8.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
188.9PRKAA1, PRKAG3, PRKAA2, PRKAG2
198.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
208.9PRKAG2, PRKAA2, PRKAG3, PRKAA1
21
Hide members
8.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2
22
Hide members
8.3BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1
23
Hide members
8.0AP2A2, MT-ND5, PRKAG2, PRKAA2, PRKAG3, PRKAA1
24
Hide members
7.9BMP2, PRKAG2, PRKAA2, PRKAG3, PRKAA1, MYH7
25
Hide members
7.4AP2A2, BMP2, JAG1, PRKAG2, PRKAA2, PRKAG3

Compounds for genes affiliated with Wolff-Parkinson-White Syndrome

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1metformin hydrochloride599.8PRKAA2, PRKAA1
2pt 1599.8PRKAA2, PRKAA1
3a 769662599.8PRKAA2, PRKAA1
4dorsomorphin dihydrochloride599.8PRKAA2, PRKAA1
5phenformin44 1110.7PRKAA1, PRKAA2
6acadesine449.6PRKAA2, PRKAA1
7phosphocreatine44 2410.4MYH7, PRKAA1, PRKAA2
8aicar44 11 2411.3PRKAA2, PRKAA1
9rapamycin449.0PRKAA1, PRKAA2, BMP2
10nitric oxide44 11 2410.5BMP2, JAG1, PRKAA2, PRKAA1, NKX2-5
11creatinine448.5MYH7, PRKAA1, PRKAA2, BMP2
12threonine448.4BMP2, MT-ND5, PRKAA2, PRKAA1, MYH7
13serine448.0MYH7, NKX2-5, PRKAA1, PRKAA2, MT-ND5, BMP2

GO Terms for genes affiliated with Wolff-Parkinson-White Syndrome

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16Gene Ontology
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Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315889.2PRKAA1, PRKAG3, PRKAG2

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of fatty acid biosynthetic processGO:04230410.2PRKAG2, PRKAA2
2carnitine shuttleGO:00685310.1PRKAG2, PRKAA2
3regulation of energy homeostasisGO:20005059.9PRKAA1, PRKAA2
4regulation of circadian rhythmGO:0427529.8PRKAA1, PRKAA2
5fatty acid homeostasisGO:0550899.8PRKAA2, PRKAA1
6cardiac muscle tissue morphogenesisGO:0550089.8BMP2, NKX2-5
7cellular response to nutrient levelsGO:0316699.8PRKAA2, PRKAA1
8adult heart developmentGO:0075129.8NKX2-5, MYH7
9positive regulation of glycolysisGO:0458219.8PRKAA1, PRKAA2
10lipid biosynthetic processGO:0086109.7PRKAA2, PRKAA1
11cellular response to glucose starvationGO:0421499.7PRKAA1, PRKAA2
12rhythmic processGO:0485119.6PRKAA1, PRKAA2
13positive regulation of autophagyGO:0105089.6PRKAA1, PRKAA2
14cholesterol biosynthetic processGO:0066959.6PRKAA1, PRKAA2
15negative regulation of TOR signaling cascadeGO:0320079.5PRKAA2, PRKAA1
16cardiac muscle cell differentiationGO:0550079.3NKX2-5, BMP2
17fatty acid biosynthetic processGO:0066339.2PRKAA1, PRKAG3, PRKAA2, PRKAG2
18cell cycle arrestGO:0070509.2PRKAG2, PRKAA2, PRKAG3, PRKAA1
19insulin receptor signaling pathwayGO:0082869.2PRKAG2, PRKAA2, PRKAG3, PRKAA1

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityGO:0473229.6PRKAA1, PRKAA2
2[acetyl-CoA carboxylase] kinase activityGO:0504059.5PRKAA1, PRKAA2
3histone serine kinase activityGO:0351749.3PRKAA2, PRKAA1
4AMP-activated protein kinase activityGO:0046799.2PRKAA1, PRKAG3, PRKAA2
5ATP bindingGO:0055248.4MYH7, PRKAA1, PRKAG3, PRKAA2, PRKAG2

Products for genes affiliated with Wolff-Parkinson-White Syndrome

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Sources for Wolff-Parkinson-White Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet