Wolfram Syndrome 2 malady

MalaCards: Wolfram Syndrome 2, also known as WFS2, is related to wolfram syndrome and diabetes mellitus. An important gene associated with Wolfram Syndrome 2 is CISD2 (CDGSH iron sulfur domain 2). The compound iron have been mentioned in the context of this disorder.

OMIM: 604928

wolfram syndrome 2 16 33 43 wfs2 16

Disease types for wolfram syndrome family:

wolfram syndrome 2

Diseases related to wolfram syndrome 2 by text searches and GeneDecks gene sharing:

(show all 41)

id	Related Disease	Score	Top Affiliating Genes
1	wolfram syndrome	34.1	WFS1, TOMM40, CISD2, CISD1
2	diabetes mellitus	29.5	CISD1, CISD2, WFS1
3	optic atrophy	29.4	CISD2, WFS1
4	diabetes insipidus	28.9	CISD2, WFS1
5	hearing loss	8.4
6	wolfram syndrome-like disease	7.8
7	sensorineural hearing loss	7.5
8	insulinoma	6.9
9	insulin resistance	6.9
10	neuropathy	6.9
11	pancreatitis	6.9
12	wolf-hirschhorn syndrome	6.9
13	parkinson's disease	6.5
14	bipolar disorder	6.5
15	gestational diabetes	6.5
16	headache	6.5
17	neurodegenerative disease	6.5
18	bipolar affective disorder	6.0
19	dfna 6/14/38 nonsyndromic hearing loss and deafness	6.0
20	dfna6/14/38 nonsyndromic low frequency sensorineural hearing loss	6.0
21	mood disorder	6.0
22	neuronitis	6.0
23	wfs1-related disorders	6.0
24	waterhouse-friderichsen syndrome	6.0
25	ataxia	6.0
26	diabetes mellitus, noninsulin-dependent	6.0
27	diabetes mellitus, noninsulin-dependent, association with	6.0
28	deafness, autosomal dominant 6/14/38	6.0
29	myoclonus	6.0
30	peripheral neuropathy	6.0
31	wolfram-like syndrome, autosomal dominant	6.0
32	prostatitis	5.1
33	was-related disorders	5.1
34	chromosome 4p deletion	5.1
35	fibrosis	5.1
36	glomerulonephritis	5.1
37	gingivitis	5.1
38	nephritis	5.1
39	obesity	5.1
40	periodontitis	5.1
41	prostate cancer	5.1

Clinical features from OMIM: 604928

Approved drugs:

Drug clinical trials:

Genetic tests related to wolfram syndrome 2:

id	Genetic test	Affiliating Genes
1	Wolfram Syndrome 2 clinical/research	CISD2

Articles related to wolfram syndrome 2:

id	Title	Authors	Year	Affiliating Genes
1	Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. (19580816)	Conlan A.R.... Paddock M.L.	2009	TOMM40, CISD1, CISD2
2	A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2. (17846994)	Amr S.... Shiang R.	2007	WFS1, CISD2

Genes related to wolfram syndrome 2 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CISD2	CDGSH iron sulfur domain 2	11.1	Summaries, Publications, Aliases & Descriptions
2	CISD1	CDGSH iron sulfur domain 1	11.0	Publications
3	TOMM40	translocase of outer mitochondrial membrane 40 homolog (yeast)	11.0	Publications
4	WFS1	Wolfram syndrome 1 (wolframin)	11.0	Publications

Compounds related to wolfram syndrome 2 according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	iron32 18	10.3	CISD1, CISD2

Cellular components related to wolfram syndrome 2 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial outer membrane	GO:005741	9.3	CISD1, CISD2

Molecular functions related to wolfram syndrome 2 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	2 iron, 2 sulfur cluster binding	GO:051537	9.3	CISD1, CISD2