MCID: WND001
MIFTS: 31

Wound Botulism

Categories: Skin diseases, Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Wound Botulism

MalaCards integrated aliases for Wound Botulism:

Name: Wound Botulism 12 55 14 69
Cutaneous Toxin-Mediated Botulism 55
Cutaneous Infectious Botulism 55
Skin Toxin-Mediated Botulism 55
Skin Infectious Botulism 55
Inoculation Botulism 55

Characteristics:

Orphanet epidemiological data:

55
wound botulism
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages;

Classifications:



Summaries for Wound Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted_by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary : Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and respiratory failure, and has symptoms including urinary retention, ptosis and diplopia. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). Affiliated tissues include skin and testes.

Related Diseases for Wound Botulism

Diseases related to Wound Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 32.4 LY96 PAX3
2 respiratory failure 10.0
3 cardiac arrest 9.8
4 tetanus 9.8
5 cellulitis 9.8
6 cranial nerve palsy 9.8
7 cocaine abuse 9.8
8 dysphagia 9.8
9 head injury 9.8
10 intestinal botulism 9.6 FBXW2 LY96
11 infant botulism 9.5 FBXW2 LY96
12 miller-dieker lissencephaly syndrome 9.4 FBXW2 LY96

Graphical network of the top 20 diseases related to Wound Botulism:



Diseases related to Wound Botulism

Symptoms & Phenotypes for Wound Botulism

Human phenotypes related to Wound Botulism:

55 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 urinary retention 55 31 frequent (33%) Frequent (79-30%) HP:0000016
2 ptosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0000508
3 diplopia 55 31 hallmark (90%) Very frequent (99-80%) HP:0000651
4 dysarthria 55 31 hallmark (90%) Very frequent (99-80%) HP:0001260
5 cardiac arrest 55 31 occasional (7.5%) Occasional (29-5%) HP:0001695
6 fever 55 31 occasional (7.5%) Occasional (29-5%) HP:0001945
7 dysphagia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002015
8 constipation 55 31 hallmark (90%) Very frequent (99-80%) HP:0002019
9 dyspnea 55 31 frequent (33%) Frequent (79-30%) HP:0002094
10 respiratory insufficiency due to muscle weakness 55 31 frequent (33%) Frequent (79-30%) HP:0002747
11 diaphragmatic paralysis 55 31 hallmark (90%) Very frequent (99-80%) HP:0006597
12 cranial nerve paralysis 55 31 hallmark (90%) Very frequent (99-80%) HP:0006824
13 mydriasis 55 31 hallmark (90%) Very frequent (99-80%) HP:0011499
14 cerebral palsy 55 31 hallmark (90%) Very frequent (99-80%) HP:0100021
15 muscle weakness 55 Very frequent (99-80%)

Drugs & Therapeutics for Wound Botulism

Search Clinical Trials , NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

Anatomical Context for Wound Botulism

MalaCards organs/tissues related to Wound Botulism:

38
Skin, Testes

Publications for Wound Botulism

Articles related to Wound Botulism:

(show top 50) (show all 83)
# Title Authors Year
1
Wound botulism, its neurological manifestations, treatment and outcomes: A case series from the Glasgow outbreak, 2015. ( 28480790 )
2017
2
Black Tar Heroin Skin Popping as a Cause of Wound Botulism. ( 28569348 )
2017
3
A Case of Localized, Unilateral (Cephalic) Wound Botulism. ( 29293932 )
2017
4
Effective and rapid treatment of wound botulism, a case report. ( 29073888 )
2017
5
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015. ( 29293923 )
2017
6
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. ( 25838491 )
2015
7
Wound botulism after traumatic open fracture in Italy. ( 26397301 )
2015
8
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. ( 24659304 )
2014
9
Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. ( 24229788 )
2013
10
Wound botulism presenting as a deep neck space infection. ( 22645053 )
2012
11
Wound botulism resulting from heroin abuse: can you recognize it? ( 21514644 )
2012
12
Recurrent wound botulism among injection drug users in California. ( 21317399 )
2011
13
Wound botulism complicating internal fixation of a complex radial fracture. ( 20007390 )
2010
14
Wound botulism in drug users: a still underestimated diagnosis. ( 20552239 )
2010
15
Images in clinical medicine: Wound botulism. ( 21158660 )
2010
16
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. ( 20046244 )
2009
17
Outbreak of wound botulism in injecting drug users. ( 19351433 )
2009
18
Sensitivity of mouse bioassay in clinical wound botulism. ( 19435438 )
2009
19
Cortical recovery of swallowing function in wound botulism. ( 18462489 )
2008
20
Wound botulism from heroin skin popping. ( 18957182 )
2008
21
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. ( 17393137 )
2007
22
First case of type E wound botulism diagnosed using real-time PCR. ( 17881556 )
2007
23
Wound botulism in injection drug users. ( 17582887 )
2007
24
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. ( 17356188 )
2007
25
A rare differential diagnosis in dysphagia: wound botulism. ( 16652098 )
2006
26
Wound botulism acquired in the Amazonian rain forest of Ecuador. ( 16606997 )
2006
27
Outbreak of wound botulism in injecting drug users in Germany, October-December 2005. ( 16794295 )
2005
28
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. ( 16280612 )
2005
29
Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments. ( 16145075 )
2005
30
Wound botulism in the UK and Ireland. ( 15150338 )
2004
31
Wound botulism. ( 15082850 )
2004
32
Wound botulism among black tar heroin users--Washington, 2003. ( 13679792 )
2003
33
Early antitoxin treatment in wound botulism results in better outcome. ( 12646758 )
2003
34
Wound botulism in an injecting drug abuser. ( 12682717 )
2003
35
[Wound botulism after drug injection]. ( 11821991 )
2002
36
Wound botulism in injecting drug users. ( 11892652 )
2002
37
Wound botulism associated with subcutaneous drug use. ( 12411365 )
2002
38
Wound botulism associated with black tar heroin and lower extremity cellulitis. ( 11348817 )
2001
39
Botulism in critical care: a case study in wound botulism. ( 11340740 )
2001
40
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. ( 11502659 )
2001
41
Transient paralysis of the bladder due to wound botulism. ( 11464047 )
2001
42
Wound botulism in drug addicts in the United Kingdom. ( 11167471 )
2001
43
Wound botulism in the UK. ( 11213130 )
2001
44
Wound botulism in UK. ( 11130548 )
2000
45
Microbiological investigation into wound botulism. ( 10870286 )
2000
46
Wound botulism in injecting drug user: second case in England. ( 10905008 )
2000
47
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. ( 10773516 )
2000
48
Wound botulism in an injecting drug user in London. ( 10863833 )
2000
49
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. ( 11049786 )
2000
50
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. ( 10470586 )
1999

Variations for Wound Botulism

Expression for Wound Botulism

Search GEO for disease gene expression data for Wound Botulism.

Pathways for Wound Botulism

GO Terms for Wound Botulism

Sources for Wound Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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