MCID: WND001
MIFTS: 32

Wound Botulism malady

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10 via Orphanet, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Wound Botulism:

Name: Wound Botulism 11 53 13 67
Cutaneous Toxin-Mediated Botulism 53
Cutaneous Infectious Botulism 53
 
Skin Toxin-Mediated Botulism 53
Skin Infectious Botulism 53
Inoculation Botulism 53

Characteristics:

Orphanet epidemiological data:

53
wound botulism:
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:0050353
Orphanet53 ORPHA178475
UMLS via Orphanet68 C1306794
ICD10 via Orphanet30 A05.1

Summaries for Wound Botulism

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Disease Ontology:11 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary: Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and respiratory failure, and has symptoms including ptosis, abnormality of the pupil and diplopia. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). Affiliated tissues include skin, spinal cord and testes.

Related Diseases for Wound Botulism

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Diseases related to Wound Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1foodborne botulism11.7
2respiratory failure9.9
3drug addiction9.7
4cardiac arrest9.7
5tetanus9.7
6cellulitis9.7
7cranial nerve palsy9.7
8cocaine abuse9.7
9dysphagia9.7
10head injury9.7
11polyneuropathy due to drug9.7BRD4, LY96
12adenoiditis9.7FBXW2, LY96
13typhoidal tularemia9.6FBXW2, LY96
14amyotrophic lateral sclerosis 189.6FBXW2, LY96
15brawny scleritis9.5BRD4, LY96
16infant botulism9.3FBXW2, LY96, PAX3
17glandular tularemia8.3BRD4, C1GALT1C1, FBXW2, LY96, PAX3

Graphical network of diseases related to Wound Botulism:



Diseases related to wound botulism

Symptoms for Wound Botulism

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Human phenotypes related to Wound Botulism:

 63 53 (show all 22)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis63 53 hallmark (90%) Very frequent (99-80%) HP:0000508
2 abnormality of the pupil63 hallmark (90%) HP:0000615
3 diplopia63 53 hallmark (90%) Very frequent (99-80%) HP:0000651
4 constipation63 53 hallmark (90%) Very frequent (99-80%) HP:0002019
5 neurological speech impairment63 hallmark (90%) HP:0002167
6 diaphragmatic paralysis63 53 hallmark (90%) Very frequent (99-80%) HP:0006597
7 cranial nerve paralysis63 53 hallmark (90%) Very frequent (99-80%) HP:0006824
8 feeding difficulties in infancy63 hallmark (90%) HP:0008872
9 cerebral palsy63 53 hallmark (90%) Very frequent (99-80%) HP:0100021
10 respiratory insufficiency63 typical (50%) HP:0002093
11 abnormal renal physiology63 typical (50%) HP:0012211
12 sudden cardiac death63 occasional (7.5%) HP:0001645
13 abnormality of temperature regulation63 occasional (7.5%) HP:0004370
14 urinary retention53 Frequent (79-30%)
15 dysarthria53 Very frequent (99-80%)
16 muscle weakness53 Very frequent (99-80%)
17 cardiac arrest53 Occasional (29-5%)
18 fever53 Occasional (29-5%)
19 dysphagia53 Very frequent (99-80%)
20 dyspnea53 Frequent (79-30%)
21 respiratory insufficiency due to muscle weakness53 Frequent (79-30%)
22 mydriasis53 Very frequent (99-80%)

Drugs & Therapeutics for Wound Botulism

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Drugs for Wound Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 477651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter AgentsPhase 417734
3onabotulinumtoxinAPhase 4626
4Peripheral Nervous System AgentsPhase 422776
5Neuromuscular AgentsPhase 41129
6Cholinergic AgentsPhase 43846
7Botulinum ToxinsPhase 4669
8Botulinum Toxins, Type APhase 4630
9abobotulinumtoxinAPhase 4626
10incobotulinumtoxinAPhase 4635

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4
2Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke PatientsNot yet recruitingNCT03024190

Search NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

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Anatomical Context for Wound Botulism

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MalaCards organs/tissues related to Wound Botulism:

35
Skin, Spinal cord, Testes

Animal Models for Wound Botulism or affiliated genes

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Publications for Wound Botulism

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Articles related to Wound Botulism:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Wound botulism after traumatic open fracture in Italy. (26397301)
2015
2
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. (25838491)
2015
3
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. (24659304)
2014
4
Wound botulism resulting from heroin abuse: can you recognize it? (21514644)
2012
5
Wound botulism presenting as a deep neck space infection. (22645053)
2012
6
Recurrent wound botulism among injection drug users in California. (21317399)
2011
7
Images in clinical medicine: Wound botulism. (21158660)
2010
8
Wound botulism complicating internal fixation of a complex radial fracture. (20007390)
2010
9
Sensitivity of mouse bioassay in clinical wound botulism. (19435438)
2009
10
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. (20046244)
2009
11
Wound botulism from heroin skin popping. (18957182)
2008
12
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. (17356188)
2007
13
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. (17393137)
2007
14
First case of type E wound botulism diagnosed using real-time PCR. (17881556)
2007
15
Wound botulism acquired in the Amazonian rain forest of Ecuador. (16606997)
2006
16
A rare differential diagnosis in dysphagia: wound botulism. (16652098)
2006
17
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. (16280612)
2005
18
Wound botulism. (15082850)
2004
19
Early antitoxin treatment in wound botulism results in better outcome. (12646758)
2003
20
Wound botulism associated with subcutaneous drug use. (12411365)
2002
21
Wound botulism in injecting drug users. (11892652)
2002
22
Wound botulism associated with black tar heroin and lower extremity cellulitis. (11348817)
2001
23
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. (11502659)
2001
24
Transient paralysis of the bladder due to wound botulism. (11464047)
2001
25
Wound botulism in injecting drug user: second case in England. (10905008)
2000
26
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. (11049786)
2000
27
Wound botulism in UK. (11130548)
2000
28
Microbiological investigation into wound botulism. (10870286)
2000
29
Wound botulism in an injecting drug user in London. (10863833)
2000
30
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
31
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. (10470586)
1999
32
Wound botulism associated with black tar heroin. (9262701)
1997
33
Wound botulism: a clinical experience. (9419152)
1997
34
Cluster of wound botulism in California: clinical, electrophysiologic, and pathologic study. (9324085)
1997
35
Wound botulism--California, 1995. From the Center for Disease Control and Prevention. (8531319)
1996
36
Stimulated single-fiber electromyography in wound botulism. (8761277)
1996
37
Wound botulism--California, 1995. (7476845)
1995
38
Wound botulism. (7978607)
1994
39
Wound botulism in a patient with a tooth abscess: case report and review. (8507754)
1993
40
Kinetics of growth and toxigenicity of Clostridium botulinum in experimental wound botulism. (3894236)
1985
41
Wound botulism associated with a positive tensilon test. (6636734)
1983
42
Wound botulism: a life-threatening complication of hand injuries. (6338548)
1983
43
Wound botulism associated with parenteral cocaine abuse--New York City. (6801464)
1982
44
Wound botulism. (7463544)
1981
45
Wound botulism. (7421626)
1980
46
Prolonged respiratory paralysis in wound botulism. (421526)
1979
47
Ocular involvement in wound botulism. (911250)
1977
48
Wound botulism. A case report. (4406029)
1974
49
Epidemiologic, clinical and laboratory aspects of wound botulism. (4582478)
1973
50
Neuromuscular physiology of wound botulism. (4357216)
1973

Variations for Wound Botulism

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Expression for genes affiliated with Wound Botulism

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Search GEO for disease gene expression data for Wound Botulism.

Pathways for genes affiliated with Wound Botulism

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GO Terms for genes affiliated with Wound Botulism

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Sources for Wound Botulism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet