MCID: WND001
MIFTS: 31

Wound Botulism malady

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

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Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 66UMLS, 67UMLS via Orphanet, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Wound Botulism:

Name: Wound Botulism 11 13 52 66
Cutaneous Toxin-Mediated Botulism 52
Cutaneous Infectious Botulism 52
 
Skin Toxin-Mediated Botulism 52
Skin Infectious Botulism 52
Inoculation Botulism 52

Characteristics:

Orphanet epidemiological data:

52
wound botulism:
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:0050353
Orphanet52 ORPHA178475
UMLS via Orphanet67 C1306794
ICD10 via Orphanet29 A05.1

Summaries for Wound Botulism

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Disease Ontology:11 A botulism that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f), has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary: Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to botulism and hypertrophic pyloric stenosis, and has symptoms including ptosis, abnormality of the pupil and diplopia. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). Affiliated tissues include skin, spinal cord and testes.

Related Diseases for Wound Botulism

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Graphical network of the top 20 diseases related to Wound Botulism:



Diseases related to wound botulism

Symptoms for Wound Botulism

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Symptoms:

 52 (show all 15)
  • urinary retention
  • ptosis
  • diplopia
  • dysarthria
  • muscle weakness
  • cardiac arrest
  • fever
  • dysphagia
  • constipation
  • dyspnea
  • respiratory insufficiency due to muscle weakness
  • diaphragmatic paralysis
  • cranial nerve paralysis
  • mydriasis
  • cerebral palsy

HPO human phenotypes related to Wound Botulism:

(show all 13)
id Description Frequency HPO Source Accession
1 ptosis hallmark (90%) HP:0000508
2 abnormality of the pupil hallmark (90%) HP:0000615
3 diplopia hallmark (90%) HP:0000651
4 constipation hallmark (90%) HP:0002019
5 neurological speech impairment hallmark (90%) HP:0002167
6 diaphragmatic paralysis hallmark (90%) HP:0006597
7 cranial nerve paralysis hallmark (90%) HP:0006824
8 feeding difficulties in infancy hallmark (90%) HP:0008872
9 cerebral palsy hallmark (90%) HP:0100021
10 respiratory insufficiency typical (50%) HP:0002093
11 abnormal renal physiology typical (50%) HP:0012211
12 sudden cardiac death occasional (7.5%) HP:0001645
13 abnormality of temperature regulation occasional (7.5%) HP:0004370

Drugs & Therapeutics for Wound Botulism

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Drugs for Wound Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholinePhase 475251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4

Search NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

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Anatomical Context for Wound Botulism

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MalaCards organs/tissues related to Wound Botulism:

34
Skin, Spinal cord, Testes

Animal Models for Wound Botulism or affiliated genes

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Publications for Wound Botulism

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Articles related to Wound Botulism:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Wound botulism after traumatic open fracture in Italy. (26397301)
2015
2
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. (25838491)
2015
3
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. (24659304)
2014
4
Wound botulism resulting from heroin abuse: can you recognize it? (21514644)
2012
5
Wound botulism presenting as a deep neck space infection. (22645053)
2012
6
Recurrent wound botulism among injection drug users in California. (21317399)
2011
7
Images in clinical medicine: Wound botulism. (21158660)
2010
8
Wound botulism complicating internal fixation of a complex radial fracture. (20007390)
2010
9
Sensitivity of mouse bioassay in clinical wound botulism. (19435438)
2009
10
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. (20046244)
2009
11
Wound botulism from heroin skin popping. (18957182)
2008
12
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. (17356188)
2007
13
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. (17393137)
2007
14
First case of type E wound botulism diagnosed using real-time PCR. (17881556)
2007
15
Wound botulism acquired in the Amazonian rain forest of Ecuador. (16606997)
2006
16
A rare differential diagnosis in dysphagia: wound botulism. (16652098)
2006
17
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. (16280612)
2005
18
Wound botulism. (15082850)
2004
19
Early antitoxin treatment in wound botulism results in better outcome. (12646758)
2003
20
Wound botulism associated with subcutaneous drug use. (12411365)
2002
21
Wound botulism in injecting drug users. (11892652)
2002
22
Wound botulism associated with black tar heroin and lower extremity cellulitis. (11348817)
2001
23
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. (11502659)
2001
24
Transient paralysis of the bladder due to wound botulism. (11464047)
2001
25
Wound botulism in injecting drug user: second case in England. (10905008)
2000
26
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. (11049786)
2000
27
Wound botulism in UK. (11130548)
2000
28
Microbiological investigation into wound botulism. (10870286)
2000
29
Wound botulism in an injecting drug user in London. (10863833)
2000
30
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
31
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. (10470586)
1999
32
Wound botulism associated with black tar heroin. (9262701)
1997
33
Wound botulism: a clinical experience. (9419152)
1997
34
Cluster of wound botulism in California: clinical, electrophysiologic, and pathologic study. (9324085)
1997
35
Wound botulism--California, 1995. From the Center for Disease Control and Prevention. (8531319)
1996
36
Stimulated single-fiber electromyography in wound botulism. (8761277)
1996
37
Wound botulism--California, 1995. (7476845)
1995
38
Wound botulism. (7978607)
1994
39
Wound botulism in a patient with a tooth abscess: case report and review. (8507754)
1993
40
Kinetics of growth and toxigenicity of Clostridium botulinum in experimental wound botulism. (3894236)
1985
41
Wound botulism associated with a positive tensilon test. (6636734)
1983
42
Wound botulism: a life-threatening complication of hand injuries. (6338548)
1983
43
Wound botulism associated with parenteral cocaine abuse--New York City. (6801464)
1982
44
Wound botulism. (7463544)
1981
45
Wound botulism. (7421626)
1980
46
Prolonged respiratory paralysis in wound botulism. (421526)
1979
47
Ocular involvement in wound botulism. (911250)
1977
48
Wound botulism. A case report. (4406029)
1974
49
Epidemiologic, clinical and laboratory aspects of wound botulism. (4582478)
1973
50
Neuromuscular physiology of wound botulism. (4357216)
1973

Variations for Wound Botulism

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Expression for genes affiliated with Wound Botulism

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Search GEO for disease gene expression data for Wound Botulism.

Pathways for genes affiliated with Wound Botulism

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GO Terms for genes affiliated with Wound Botulism

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Biological processes related to Wound Botulism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:00301689.3C1GALT1C1, F2

Sources for Wound Botulism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet