MCID: WND001
MIFTS: 33

Wound Botulism

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

MalaCards integrated aliases for Wound Botulism:

Name: Wound Botulism 12 56 14 69
Cutaneous Toxin-Mediated Botulism 56
Cutaneous Infectious Botulism 56
Skin Toxin-Mediated Botulism 56
Skin Infectious Botulism 56
Inoculation Botulism 56

Characteristics:

Orphanet epidemiological data:

56
wound botulism
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages;

Classifications:



Summaries for Wound Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted_by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary : Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and respiratory failure, and has symptoms including dysphagia, dysarthria and diplopia. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes.

Related Diseases for Wound Botulism

Diseases related to Wound Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 foodborne botulism 11.7
2 respiratory failure 9.9
3 cranial nerve palsy 9.7
4 cocaine abuse 9.7
5 dysphagia 9.7
6 head injury 9.7
7 drug addiction 9.7
8 cardiac arrest 9.7
9 tetanus 9.7
10 cellulitis 9.7
11 infant botulism 9.6 LY96 PAX3
12 adenoiditis 9.5 FBXW2 LY96
13 lissencephaly 1 9.5 FBXW2 LY96
14 typhoidal tularemia 9.2 FBXW2 LY96
15 glandular tularemia 8.4 C1GALT1C1 FBXW2 LY96 PAX3

Graphical network of the top 20 diseases related to Wound Botulism:



Diseases related to Wound Botulism

Symptoms & Phenotypes for Wound Botulism

Human phenotypes related to Wound Botulism:

56 32 (show all 15)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysphagia 56 32 hallmark (90%) Very frequent (99-80%) HP:0002015
2 dysarthria 56 32 hallmark (90%) Very frequent (99-80%) HP:0001260
3 diplopia 56 32 hallmark (90%) Very frequent (99-80%) HP:0000651
4 ptosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0000508
5 constipation 56 32 hallmark (90%) Very frequent (99-80%) HP:0002019
6 dyspnea 56 32 frequent (33%) Frequent (79-30%) HP:0002094
7 fever 56 32 occasional (7.5%) Occasional (29-5%) HP:0001945
8 respiratory insufficiency due to muscle weakness 56 32 frequent (33%) Frequent (79-30%) HP:0002747
9 urinary retention 56 32 frequent (33%) Frequent (79-30%) HP:0000016
10 cerebral palsy 56 32 hallmark (90%) Very frequent (99-80%) HP:0100021
11 cardiac arrest 56 32 occasional (7.5%) Occasional (29-5%) HP:0001695
12 diaphragmatic paralysis 56 32 hallmark (90%) Very frequent (99-80%) HP:0006597
13 cranial nerve paralysis 56 32 hallmark (90%) Very frequent (99-80%) HP:0006824
14 mydriasis 56 32 hallmark (90%) Very frequent (99-80%) HP:0011499
15 muscle weakness 56 Very frequent (99-80%)

Drugs & Therapeutics for Wound Botulism

Drugs for Wound Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Botulinum Toxins Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Cholinergic Agents Phase 4
6 Neuromuscular Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 onabotulinumtoxinA Phase 4
9 Peripheral Nervous System Agents Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed NCT00320281 Phase 4 botulinum toxin A
2 Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke Patients Not yet recruiting NCT03024190

Search NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

Anatomical Context for Wound Botulism

MalaCards organs/tissues related to Wound Botulism:

39
Skin, Spinal Cord, Testes

Publications for Wound Botulism

Articles related to Wound Botulism:

(show top 50) (show all 80)
id Title Authors Year
1
Black Tar Heroin Skin Popping as a Cause of Wound Botulism. ( 28569348 )
2017
2
Wound botulism, its neurological manifestations, treatment and outcomes: A case series from the Glasgow outbreak, 2015. ( 28480790 )
2017
3
Wound botulism after traumatic open fracture in Italy. ( 26397301 )
2015
4
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. ( 25838491 )
2015
5
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. ( 24659304 )
2014
6
Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. ( 24229788 )
2013
7
Wound botulism resulting from heroin abuse: can you recognize it? ( 21514644 )
2012
8
Wound botulism presenting as a deep neck space infection. ( 22645053 )
2012
9
Recurrent wound botulism among injection drug users in California. ( 21317399 )
2011
10
Wound botulism in drug users: a still underestimated diagnosis. ( 20552239 )
2010
11
Wound botulism complicating internal fixation of a complex radial fracture. ( 20007390 )
2010
12
Images in clinical medicine: Wound botulism. ( 21158660 )
2010
13
Outbreak of wound botulism in injecting drug users. ( 19351433 )
2009
14
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. ( 20046244 )
2009
15
Sensitivity of mouse bioassay in clinical wound botulism. ( 19435438 )
2009
16
Cortical recovery of swallowing function in wound botulism. ( 18462489 )
2008
17
Wound botulism from heroin skin popping. ( 18957182 )
2008
18
Wound botulism in injection drug users. ( 17582887 )
2007
19
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. ( 17356188 )
2007
20
First case of type E wound botulism diagnosed using real-time PCR. ( 17881556 )
2007
21
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. ( 17393137 )
2007
22
A rare differential diagnosis in dysphagia: wound botulism. ( 16652098 )
2006
23
Wound botulism acquired in the Amazonian rain forest of Ecuador. ( 16606997 )
2006
24
Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments. ( 16145075 )
2005
25
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. ( 16280612 )
2005
26
Outbreak of wound botulism in injecting drug users in Germany, October-December 2005. ( 16794295 )
2005
27
Wound botulism. ( 15082850 )
2004
28
Wound botulism in the UK and Ireland. ( 15150338 )
2004
29
Early antitoxin treatment in wound botulism results in better outcome. ( 12646758 )
2003
30
Wound botulism in an injecting drug abuser. ( 12682717 )
2003
31
Wound botulism among black tar heroin users--Washington, 2003. ( 13679792 )
2003
32
Wound botulism in injecting drug users. ( 11892652 )
2002
33
[Wound botulism after drug injection]. ( 11821991 )
2002
34
Wound botulism associated with subcutaneous drug use. ( 12411365 )
2002
35
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. ( 11502659 )
2001
36
Wound botulism in drug addicts in the United Kingdom. ( 11167471 )
2001
37
Transient paralysis of the bladder due to wound botulism. ( 11464047 )
2001
38
Wound botulism associated with black tar heroin and lower extremity cellulitis. ( 11348817 )
2001
39
Botulism in critical care: a case study in wound botulism. ( 11340740 )
2001
40
Wound botulism in the UK. ( 11213130 )
2001
41
Wound botulism in an injecting drug user in London. ( 10863833 )
2000
42
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. ( 11049786 )
2000
43
Wound botulism in UK. ( 11130548 )
2000
44
Microbiological investigation into wound botulism. ( 10870286 )
2000
45
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. ( 10773516 )
2000
46
Wound botulism in injecting drug user: second case in England. ( 10905008 )
2000
47
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. ( 10470586 )
1999
48
Wound botulism associated with black tar heroin. ( 9809721 )
1998
49
Wound botulism associated with black tar heroin. ( 9809720 )
1998
50
Wound botulism associated with black tar heroin among injecting drug users. ( 9516001 )
1998

Variations for Wound Botulism

Expression for Wound Botulism

Search GEO for disease gene expression data for Wound Botulism.

Pathways for Wound Botulism

GO Terms for Wound Botulism

Sources for Wound Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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