MCID: WND001
MIFTS: 31

Wound Botulism malady

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

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Sources:
11Disease Ontology, 13DISEASES, 31ICD10 via Orphanet, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Wound Botulism:

Name: Wound Botulism 11 54 13 68
Cutaneous Toxin-Mediated Botulism 54
Cutaneous Infectious Botulism 54
 
Skin Toxin-Mediated Botulism 54
Skin Infectious Botulism 54
Inoculation Botulism 54

Characteristics:

Orphanet epidemiological data:

54
wound botulism:
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:0050353
Orphanet54 ORPHA178475
UMLS via Orphanet69 C1306794
ICD10 via Orphanet31 A05.1

Summaries for Wound Botulism

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Disease Ontology:11 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary: Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and glandular tularemia, and has symptoms including Array, Array and Array. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). Affiliated tissues include skin and testes.

Related Diseases for Wound Botulism

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Diseases related to Wound Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1foodborne botulism11.7
2glandular tularemia10.0LY96, PAX3
3respiratory failure9.9
4otomycosis9.9FBXW2, LY96
5amyotrophic lateral sclerosis 189.9FBXW2, LY96
6carrion's disease9.8FBXW2, LY96
7leopard syndrome9.8BRD4, LY96
8drug addiction9.7
9cardiac arrest9.7
10tetanus9.7
11cellulitis9.7
12cranial nerve palsy9.7
13cocaine abuse9.7
14dysphagia9.7
15head injury9.7
16typhoidal tularemia9.3BRD4, C1GALT1C1, FBXW2, LY96, PAX3

Graphical network of diseases related to Wound Botulism:



Diseases related to wound botulism

Symptoms & Phenotypes for Wound Botulism

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Human phenotypes related to Wound Botulism:

 54 64 (show all 15)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 urinary retention64 54 Frequent (79-30%) HP:0000016
2 ptosis64 54 Very frequent (99-80%) HP:0000508
3 diplopia64 54 Very frequent (99-80%) HP:0000651
4 dysarthria64 54 Very frequent (99-80%) HP:0001260
5 muscle weakness54 Very frequent (99-80%)
6 cardiac arrest64 54 Occasional (29-5%) HP:0001695
7 fever64 54 Occasional (29-5%) HP:0001945
8 dysphagia64 54 Very frequent (99-80%) HP:0002015
9 constipation64 54 Very frequent (99-80%) HP:0002019
10 dyspnea64 54 Frequent (79-30%) HP:0002094
11 respiratory insufficiency due to muscle weakness64 54 Frequent (79-30%) HP:0002747
12 diaphragmatic paralysis64 54 Very frequent (99-80%) HP:0006597
13 cranial nerve paralysis64 54 Very frequent (99-80%) HP:0006824
14 mydriasis64 54 Very frequent (99-80%) HP:0011499
15 cerebral palsy64 54 Very frequent (99-80%) HP:0100021

Drugs & Therapeutics for Wound Botulism

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Drugs for Wound Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 480551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter AgentsPhase 418340
3onabotulinumtoxinAPhase 4652
4Peripheral Nervous System AgentsPhase 423689
5Neuromuscular AgentsPhase 41180
6Cholinergic AgentsPhase 43992
7Botulinum ToxinsPhase 4697
8Botulinum Toxins, Type APhase 4657
9abobotulinumtoxinAPhase 4652
10incobotulinumtoxinAPhase 4662

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4
2Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke PatientsNot yet recruitingNCT03024190

Search NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

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Anatomical Context for Wound Botulism

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MalaCards organs/tissues related to Wound Botulism:

36
Skin, Testes

Publications for Wound Botulism

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Articles related to Wound Botulism:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Wound botulism after traumatic open fracture in Italy. (26397301)
2015
2
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. (25838491)
2015
3
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. (24659304)
2014
4
Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. (24229788)
2013
5
Wound botulism resulting from heroin abuse: can you recognize it? (21514644)
2012
6
Wound botulism presenting as a deep neck space infection. (22645053)
2012
7
Recurrent wound botulism among injection drug users in California. (21317399)
2011
8
Wound botulism in drug users: a still underestimated diagnosis. (20552239)
2010
9
Images in clinical medicine: Wound botulism. (21158660)
2010
10
Wound botulism complicating internal fixation of a complex radial fracture. (20007390)
2010
11
Sensitivity of mouse bioassay in clinical wound botulism. (19435438)
2009
12
Outbreak of wound botulism in injecting drug users. (19351433)
2009
13
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. (20046244)
2009
14
Cortical recovery of swallowing function in wound botulism. (18462489)
2008
15
Wound botulism from heroin skin popping. (18957182)
2008
16
Wound botulism in injection drug users. (17582887)
2007
17
First case of type E wound botulism diagnosed using real-time PCR. (17881556)
2007
18
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. (17393137)
2007
19
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. (17356188)
2007
20
Wound botulism acquired in the Amazonian rain forest of Ecuador. (16606997)
2006
21
A rare differential diagnosis in dysphagia: wound botulism. (16652098)
2006
22
Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments. (16145075)
2005
23
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. (16280612)
2005
24
Outbreak of wound botulism in injecting drug users in Germany, October-December 2005. (16794295)
2005
25
Wound botulism in the UK and Ireland. (15150338)
2004
26
Wound botulism. (15082850)
2004
27
Wound botulism in an injecting drug abuser. (12682717)
2003
28
Wound botulism among black tar heroin users--Washington, 2003. (13679792)
2003
29
Early antitoxin treatment in wound botulism results in better outcome. (12646758)
2003
30
Wound botulism in injecting drug users. (11892652)
2002
31
Wound botulism associated with subcutaneous drug use. (12411365)
2002
32
Wound botulism after drug injection]. (11821991)
2002
33
Wound botulism in the UK. (11213130)
2001
34
Transient paralysis of the bladder due to wound botulism. (11464047)
2001
35
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. (11502659)
2001
36
Botulism in critical care: a case study in wound botulism. (11340740)
2001
37
Wound botulism associated with black tar heroin and lower extremity cellulitis. (11348817)
2001
38
Wound botulism in drug addicts in the United Kingdom. (11167471)
2001
39
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
40
Wound botulism in injecting drug user: second case in England. (10905008)
2000
41
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. (11049786)
2000
42
Wound botulism in UK. (11130548)
2000
43
Microbiological investigation into wound botulism. (10870286)
2000
44
Wound botulism in an injecting drug user in London. (10863833)
2000
45
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. (10470586)
1999
46
Wound botulism associated with black tar heroin. (9809720)
1998
47
Wound botulism associated with black tar heroin among injecting drug users. (9516001)
1998
48
Wound botulism associated with black tar heroin. (9809721)
1998
49
Cluster of wound botulism in California: clinical, electrophysiologic, and pathologic study. (9324085)
1997
50
Wound botulism: a clinical experience. (9419152)
1997

Variations for Wound Botulism

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Expression for genes affiliated with Wound Botulism

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Search GEO for disease gene expression data for Wound Botulism.

Pathways for genes affiliated with Wound Botulism

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GO Terms for genes affiliated with Wound Botulism

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Sources for Wound Botulism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet