Aliases & Classifications for Wrinkles

MalaCards integrated aliases for Wrinkles:

Name: Wrinkles 37

Summaries for Wrinkles

MalaCards based summary : Wrinkles is related to cutis laxa and cutis laxa, autosomal dominant 1. An important gene associated with Wrinkles is ALDH18A1 (Aldehyde Dehydrogenase 18 Family Member A1), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone.

Wikipedia : 72 A wrinkle, also known as a rhytide, is a fold, ridge or crease in the skin or on fabric. Skin wrinkles... more...

Related Diseases for Wrinkles

Diseases related to Wrinkles via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 cutis laxa 31.5 ALDH18A1 ELN
2 cutis laxa, autosomal dominant 1 31.3 ALDH18A1 ELN
3 macroepiphyseal dysplasia with osteoporosis, wrinkled skin, and aged appearance 12.0
4 wrinkly skin syndrome 11.5
5 aquagenic syringeal acrokeratoderm 11.1
6 megarbane-jalkh syndrome 11.0
7 prune belly syndrome 10.9
8 ehlers-danlos syndrome, musculocontractural type, 1 10.9
9 ehlers-danlos syndrome, spondylodysplastic type, 3 10.9
10 cutis laxa, autosomal dominant 3 10.9
11 cutis laxa, autosomal recessive, type iic 10.9
12 cutis laxa, autosomal recessive, type iid 10.9
13 microcephalic primordial dwarfism, montreal type 10.9
14 cantu sanchez-corona hernandez syndrome 10.9
15 beare-stevenson cutis gyrata syndrome 10.8
16 lenz-majewski hyperostotic dwarfism 10.8
17 cutis laxa, autosomal recessive, type ia 10.8
18 cutis laxa, autosomal recessive, type iia 10.8
19 gapo syndrome 10.8
20 geroderma osteodysplasticum 10.8
21 miller-dieker lissencephaly syndrome 10.8
22 ogden syndrome 10.8
23 cutis laxa, autosomal recessive, type iib 10.8
24 cutis laxa, autosomal recessive, type ic 10.8
25 cholera 10.8
26 de barsy syndrome 10.8
27 geroderma osteodysplastica 10.8
28 granulomatous slack skin disease 10.8
29 pachygyria 10.8
30 aging 10.2
31 critical limb ischemia 10.1 HGF VEGFA
32 chronic myocardial ischemia 10.1 HGF VEGFA
33 cystic fibrosis 10.1
34 nodular goiter 10.1 HGF VEGFA
35 fibrosis of extraocular muscles, congenital, 1 10.0
36 limb ischemia 10.0 HGF VEGFA
37 microvascular complications of diabetes 1 10.0 HGF VEGFA
38 multiple mitochondrial dysfunctions syndrome 5 9.9
39 keratoconus 9.9
40 neuropathy 9.9
41 mid-dermal elastolysis 9.9
42 doxorubicin induced cardiomyopathy 9.8 CSF3 HGF
43 arcus corneae 9.7
44 erythermalgia, primary 9.7
45 otitis media 9.7
46 paine syndrome 9.7
47 supranuclear palsy, progressive, 1 9.7
48 congenital disorder of glycosylation, type in 9.7
49 glass syndrome 9.7
50 episodic pain syndrome, familial, 1 9.7

Graphical network of the top 20 diseases related to Wrinkles:



Diseases related to Wrinkles

Symptoms & Phenotypes for Wrinkles

Drugs & Therapeutics for Wrinkles

Drugs for Wrinkles (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 132)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4 Racepinephrine Approved Phase 4 329-65-7
5
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 9004-61-9 53477741 24759
6
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
7
Ethanol Approved Phase 4,Phase 3 64-17-5 702
8
Kinetin Approved Phase 4 525-79-1 3830
9
Polidocanol Approved Phase 4 9002-92-0
10
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
11
Tetracaine Approved, Vet_approved Phase 4,Phase 3 94-24-6 5411
12
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
13
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
14
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
16 Tocopherol Approved, Investigational, Nutraceutical Phase 4
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
18
Tretinoin Approved, Investigational, Nutraceutical Phase 4,Phase 2 302-79-4 5538
19
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 68-26-8, 11103-57-4 445354
20 tannic acid Approved, Nutraceutical Phase 4
21 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
22 Botulinum Toxins Phase 4,Phase 3,Phase 2,Phase 1
23 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2
24 Cholinergic Agents Phase 4,Phase 3,Phase 2
25 Neuromuscular Agents Phase 4,Phase 3,Phase 2
26 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
27 onabotulinumtoxinA Phase 4,Phase 3,Phase 2
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Epinephryl borate Phase 4
30 incobotulinumtoxinA Phase 4,Phase 3,Phase 2
31 Anesthetics Phase 4,Phase 3
32 Anesthetics, Local Phase 4,Phase 3
33 Anti-Arrhythmia Agents Phase 4,Phase 3
34 Central Nervous System Depressants Phase 4,Phase 3
35 Diuretics, Potassium Sparing Phase 4,Phase 3
36 Sodium Channel Blockers Phase 4,Phase 3
37 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
38 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Viscosupplements Phase 4,Phase 3,Phase 1,Phase 2
40 Antioxidants Phase 4,Phase 2,Phase 1
41 Vitamin B 6 Phase 4
42 Vitamin B Complex Phase 4
43 Vitamins Phase 4,Phase 2,Phase 1
44 Hylan Phase 4
45 Pharmaceutical Solutions Phase 4,Phase 3
46 diuretics Phase 4
47 Natriuretic Agents Phase 4
48 Calcium, Dietary Phase 4,Phase 3
49 Carbopol 940 Phase 4
50 Mitogens Phase 4

Interventional clinical trials:

(show top 50) (show all 317)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of the Full Face Applications of Variable Doses of a Commercial Botulinum Toxin Type a (Dysport®) Unknown status NCT01032954 Phase 4 Botulinum toxin
2 A Clinical Study to Evaluate the Efficacy and Safety of HA IDF II Plus Versus HA IDF II in Nasolabial Fold Injection Unknown status NCT02340078 Phase 4
3 A Study Evaluating Blended Belotero for the Treatment of Etched-in Fine Facial Lines Unknown status NCT02626598 Phase 4
4 Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids Unknown status NCT01583478 Phase 4
5 Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers Unknown status NCT01492140 Phase 4
6 Perception of Facial Expressions Following Correction of Wrinkles and Folds Completed NCT02573337 Phase 4
7 Study of Restylane and Perlane in the Correction of Peri-Oral Wrinkles Completed NCT00977704 Phase 4
8 TEOSYAL® PureSense Redensity [I] Injection Using MicronJet® Needle in the Treatment of Crow's Feet Wrinkles Completed NCT02497846 Phase 4
9 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds Completed NCT01269801 Phase 4 onabotulinumtoxinA;JUVÉDERM
10 Ablative Fractional Lasers to Treat Peri-orbital Rhytides Completed NCT00990431 Phase 4
11 Emervel for the Correction of Lower Face Wrinkles & Folds Completed NCT02718040 Phase 4
12 Comparison of Outcome Parameters in Laser Rhytide Treatment Completed NCT00994474 Phase 4
13 Treatment With Botulinum Toxin Type A (BOTOX®) in Chinese Patients With Moderate to Severe Frown Lines Completed NCT01814670 Phase 4
14 Comparison of Two Commercial Preparations of Botulinum Toxin Type A Completed NCT00959907 Phase 4 BOTULINUM TOXIN TYPE-A
15 Comparative Study of the Effect of Dysport and Botox Completed NCT00434863 Phase 4 botulinum toxin type A
16 A Clinical Study to Evaluate the Efficacy and Safety of HA IDF Plus Versus HA IDF in Nasolabial Fold Injection Completed NCT02340091 Phase 4
17 A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides Completed NCT01777620 Phase 4 Normal Saline
18 Clinical Trial on a Topical "Antiage" Face Gel Completed NCT01948531 Phase 4 Gynomunal® gel
19 Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum Completed NCT01728337 Phase 4 Dysport;Xeomin
20 Fractional CO2 Treatment of Acne Scars in Asians Completed NCT00748462 Phase 4
21 Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A Completed NCT00989768 Phase 4 Botulinum Toxin Type A (Dysport®);Botulinum Toxin Type A/Botox®;Botulinum Toxin Type A/Dysport®
22 Fields Of Effects Of Two Commercial Preparations Of Botulinum Toxin Type A At Equal Labeled Unit Doses Completed NCT01732809 Phase 4 group A;group B
23 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
24 Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep Completed NCT02672644 Phase 4
25 A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules. Completed NCT00765583 Phase 4 Restylane
26 Post Market Safety Study and Effectiveness With Evolence in Subjects With Skin Color Types IV-VI Completed NCT00891774 Phase 4
27 A Trial of Skin Care Protocols for Facial Resurfacing Completed NCT01113606 Phase 4
28 Radial Diffusion of the Botulinum Toxin Type A (Botox®): Electromyographic Evaluation of the Frontal Muscle Completed NCT01297634 Phase 4 Botulinum Toxin Type-A (day 0);Botulinum Toxin Type-A (day 0);Botulinum Toxin Type-A (day 0)
29 Poly-L-lactic Acid for Skin Quality Completed NCT02003833 Phase 4
30 Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles Completed NCT01212809 Phase 4
31 Non-inferiority of Belotero® Basic Versus Juvéderm® Ultra 3 Completed NCT01305187 Phase 4
32 The Treatment of Glabellar Frown Lines Completed NCT02096081 Phase 4 IncobotulinumtoxinA;OnabotulinumtoxinA
33 Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines Completed NCT01391312 Phase 4 normal saline (placebo)
34 Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines Completed NCT02718118 Phase 4
35 Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler Completed NCT01012661 Phase 4
36 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
37 Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study Completed NCT01529788 Phase 4 Right lateral orbital injection of Botox Cosmetic or Dysport;Left lateral orbital injection of Botox Cosmetic or Dysport
38 Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines Completed NCT01271452 Phase 4
39 Evaluation Onset Time of DWP450-004 and Safety in Moderate-severe Glabellar Lines Completed NCT02568150 Phase 4
40 A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure Completed NCT01787461 Phase 4
41 Efficacy and Safety of Kinetin 0.1% for Treatment of Skin Photoaging Completed NCT01898182 Phase 4
42 Botox Cosmetic and the Young Patient With Glabellar Furrows Completed NCT00856999 Phase 4 Botox
43 (Macrolane VR30) in Buttocks Reshaping and contouringCellulite (Macrolane VR30) in Buttocks Reshaping and Contouring Completed NCT02127723 Phase 4
44 Study to Evaluate the Effect of a Nu Skin Product and Device for Brown Spots Completed NCT01149876 Phase 4 Tretinoin cream 0.05
45 A Multi-center Long Term Efficacy Trial of the GFX For Reduction of Glabellar Furrowing Completed NCT00611273 Phase 4
46 Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study) Completed NCT02176356 Phase 4 bimatoprost ophthalmic solution 0.03%
47 Effect of Revival Soy on Weight Loss and Skin, Hair, and Nails in Premenopausal Women Completed NCT00352157 Phase 4
48 Efficacy and Safety Study of Kinerase® for Treatment of Cutaneous Facial Photodamage Completed NCT01885091 Phase 4
49 Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules Completed NCT02765763 Phase 4 2-Minute Reveal Masque;24/7 Barrier Repair Cream;8-in-1 BioSerum;Null Formula 2-Minute Reveal Masque;Null Formula 24/7 Barrier Repair Cream;Null Formula 8-in-1 BioSerum
50 Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment Completed NCT02297516 Phase 4 Azzalure or Dysport

Search NIH Clinical Center for Wrinkles

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Wrinkles cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Wrinkles:
LAVIV
Stemedyne
Embryonic/Adult Cultured Cells Related to Wrinkles:
Skin-derived fibroblasts PMIDs: 23731590 10937098 23211390 23566237 10805306 22409385 17338681
Bone marrow-derived mesenchymal stem cells (Stemedyne PMIDs: 23295150

Genetic Tests for Wrinkles

Anatomical Context for Wrinkles

MalaCards organs/tissues related to Wrinkles:

38
Skin, Eye, Bone, Testes, Brain, Thyroid, Heart

Publications for Wrinkles

Articles related to Wrinkles:

(show top 50) (show all 163)
# Title Authors Year
1
Aquagenic Wrinkling of the Palms in Patients with Cystic Fibrosis. ( 29451691 )
2018
2
Writing Wrinkles on Poly(dimethylsiloxane) (PDMS) by Surface Oxidation with a CO<sub>2</sub>Laser Engraver. ( 29302968 )
2018
3
Universal Method for Creating Hierarchical Wrinkles on Thin-Film Surfaces. ( 29179552 )
2018
4
On skin microrelief and the emergence of expression micro-wrinkles. ( 29319711 )
2018
5
Using normal and high pulse coverage with picosecond laser treatment of wrinkles and acne scarring: Long term clinical observations. ( 29140537 )
2018
6
Oblique wrinkles. ( 28373381 )
2017
7
Corrigendum to "Topical application of neem leaves prevents wrinkles formation in UVB-exposed hairless mice" [J. Photochem. Photobiol. B Biol. 169 (April 2017) 161-170]. ( 28965841 )
2017
8
Coenzyme Q10 and retinaldehyde co-loaded nanostructured lipid carriers for efficacy evaluation in wrinkles. ( 28895754 )
2017
9
Biomimetics in thin film design: Niche-like wrinkles designed for i-cell progenitor cell differentiation. ( 28866177 )
2017
10
New soft tissue filler derived from autologous keratin and fibroblast for neck wrinkles. ( 29160000 )
2017
11
Bio-inspired hierarchical micro- and nano-wrinkles obtained via mechanically directed self-assembly on shape-memory polymers. ( 28504298 )
2017
12
Launching Phonon Polaritons by Natural Boron Nitride Wrinkles with Modifiable Dispersion by Dielectric Environments. ( 28833592 )
2017
13
Multimodal Approach for Treating Horizontal Neck Wrinkles Using Intensity Focused Ultrasound, Cohesive Polydensified Matrix Hyaluronic Acid, and IncobotulinumtoxinA. ( 28902030 )
2017
14
Esotropia following botulinum toxin type A injection for facial wrinkles. ( 28682151 )
2017
15
Classification of facial wrinkles among Chinese women. ( 28808192 )
2017
16
Dynamic pattern of wrinkles in a dielectric elastomer. ( 28357441 )
2017
17
Crack-Free, Soft Wrinkles Enable Switchable Anisotropic Wetting. ( 28452417 )
2017
18
Effect of thread embedding acupuncture for facial wrinkles and laxity: a single-arm, prospective, open-label study. ( 29296569 )
2017
19
Corrigendum: The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles. ( 29200788 )
2017
20
Achieving high aspect ratio wrinkles by modifying material network stress. ( 28555680 )
2017
21
Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. ( 28761365 )
2017
22
Buckling of an Elastic Ridge: Competition between Wrinkles and Creases. ( 28474925 )
2017
23
Clinical and Histological Studies of Suborbital Wrinkles Treated with Fractional Bipolar Radiofrequency. ( 28712336 )
2017
24
Efficacy of long pulse Nd:YAG laser versus fractional Er:YAG laser in the treatment of hand wrinkles. ( 28990118 )
2017
25
Hyaluronic acid microneedle patch for the improvement of crow's feet wrinkles. ( 28892233 )
2017
26
YouTube Videos on Botulinum Toxin A for Wrinkles: A Useful Resource for Patient Education. ( 28877151 )
2017
27
The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles. ( 28392646 )
2017
28
Efficacy and Safety of an Anti-aging Technology for the Treatment of Facial Wrinkles and Skin Moisturization. ( 29399264 )
2017
29
Treatment of periorbital wrinkles using multipolar fractional radiofrequency in Korean patients. ( 27686890 )
2017
30
Buckling patterns in biaxially pre-stretched bilayer shells: wrinkles, creases, folds and fracture-like ridges. ( 29044284 )
2017
31
Comparison of the Clinical Efficacy of Abobotulinumtoxin A (ABO) and Onabotulinumtoxin A (ONA) in the Treatment of Crow's Feet Wrinkles: A Split-Face Study. ( 29278961 )
2017
32
Self-similar Hierarchical Wrinkles as a Potential Multifunctional Smart Window with Simultaneously Tunable Transparency, Structural Color, and Droplet Transport. ( 28702991 )
2017
33
Nonequilibrium ferroelectric-ferroelastic 10a88nm nanodomains: wrinkles, period-doubling, and power-law relaxation. ( 28643699 )
2017
34
Self-cleaning by harnessing wrinkles in two-dimensional layered crystals. ( 29211077 )
2017
35
The smectic order of wrinkles. ( 28719599 )
2017
36
Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in HairlessA Mouse Skin. ( 26854493 )
2016
37
Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. ( 27474688 )
2016
38
Effects of hormones on skin wrinkles and rigidity vary by race/ethnicity: four-year follow-up fromA the ancillary skin study of the Kronos Early Estrogen Prevention Study. ( 27393520 )
2016
39
Are Eyes a Mirror of the Soul? What Eye Wrinkles Reveal about a Horse's Emotional State. ( 27732647 )
2016
40
Safety and efficacy of a novel diffractive lens array using a picosecond 755a88nm alexandrite laser for treatment of wrinkles. ( 27681221 )
2016
41
Reversible wrinkles of monolayer graphene on a polymer substrate: toward stretchable and flexible electronics. ( 26924574 )
2016
42
Reply: A Prospective, Split-Face, Randomized, Double-Blind Study Comparing OnabotulinumtoxinA to IncobotulinumtoxinA for Upper Face Wrinkles. ( 27307326 )
2016
43
Fractional non - ablative laser treatment 1410 nm for periorbital wrinkles - reviscometrical and clinical evaluation. ( 26963078 )
2016
44
Frontal Alopecia after Repeated Botulinum Toxin Type A Injections for Forehead Wrinkles: An Underestimated Entity? ( 27843928 )
2016
45
Wrinkles, folds and calcifications: Reduced durability after transcatheter aortic valve-in-valve replacement. ( 27665219 )
2016
46
Hyaluronic acid injection via a pneumatic microjet device to improve forehead wrinkles. ( 27503619 )
2016
47
The amelioration effect of tranexamic acid in wrinkles induced by skin dryness. ( 27133035 )
2016
48
A study of facial wrinkles improvement effect of veratric acid from cauliflower mushroom through photo-protective mechanisms against UVB irradiation. ( 26914455 )
2016
49
Morse wrinkles to Bt susceptibility. ( 27715450 )
2016
50
P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. ( 26286607 )
2016

Variations for Wrinkles

Expression for Wrinkles

Search GEO for disease gene expression data for Wrinkles.

Pathways for Wrinkles

GO Terms for Wrinkles

Cellular components related to Wrinkles according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 CSF3 HGF LPL PDGFA VEGFA
2 extracellular region GO:0005576 9.43 CSF3 ELN HGF LPL PDGFA VEGFA
3 platelet alpha granule lumen GO:0031093 8.8 HGF PDGFA VEGFA

Biological processes related to Wrinkles according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.62 CSF3 HGF PDGFA VEGFA
2 positive regulation of cell migration GO:0030335 9.61 HGF PDGFA VEGFA
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.55 CSF3 VEGFA
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.54 HGF VEGFA
5 positive regulation of protein kinase B signaling GO:0051897 9.54 CSF3 HGF PDGFA
6 positive regulation of MAP kinase activity GO:0043406 9.52 PDGFA VEGFA
7 positive regulation of cell division GO:0051781 9.51 PDGFA VEGFA
8 positive chemotaxis GO:0050918 9.49 HGF VEGFA
9 positive regulation of mesenchymal cell proliferation GO:0002053 9.48 PDGFA VEGFA
10 positive regulation of protein autophosphorylation GO:0031954 9.46 PDGFA VEGFA
11 regulation of receptor activity GO:0010469 9.46 CSF3 HGF PDGFA VEGFA
12 platelet degranulation GO:0002576 9.43 HGF PDGFA VEGFA
13 macrophage differentiation GO:0030225 9.4 CSF3 VEGFA
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.13 CSF3 HGF VEGFA
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 CSF3 HGF PDGFA

Molecular functions related to Wrinkles according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.32 HGF PDGFA
2 chemoattractant activity GO:0042056 9.26 HGF VEGFA
3 extracellular matrix binding GO:0050840 9.16 ELN VEGFA
4 platelet-derived growth factor receptor binding GO:0005161 8.96 PDGFA VEGFA
5 growth factor activity GO:0008083 8.92 CSF3 HGF PDGFA VEGFA

Sources for Wrinkles

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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