X-linked Disease malady

Wikipedia: Sex linkage is the phenotypic expression of an allele related to the chromosomal sex of the individual....⁴⁴ more...

MalaCards: X-linked Disease is related to mental retardation, x-linked, fraxe type and retinoschisis. An important gene associated with X-linked Disease is TIMM8A (translocase of inner mitochondrial membrane 8 homolog A (yeast)). The compounds carnitine and acetyl-l-carnitine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and nervous system.

x-linked disease 6

Disease types for x-linked disease family:

y-linked disease

Diseases related to x-linked disease by text searches and GeneDecks gene sharing:

(show all 15)

id	Related Disease	Score	Top Affiliating Genes
1	mental retardation, x-linked, fraxe type	12.8	FRAXE, AFF2
2	retinoschisis	12.7	PDHA1, ZFX
3	fragile x syndrome	12.4	FRAXE, AFF2
4	stickler syndrome	12.4	OTC, CHM
5	mental retardation syndrome	12.3	CHM, AFF2
6	premature ovarian failure	12.3	FRAXE, AFF2, ZFX
7	recessive developmental delay, small stature, microcephaly and brain calcifications	12.1	OTC, AFF2
8	rett syndrome	12.0	OTC, GJB1
9	x inactivation	12.0	OTC, ZFX, TIMM8A
10	intellectual disability	11.8	OTC, AFF2, FRAXE
11	twinning	11.6	AFF2, TIMM8A, OTC, FRAXE
12	mayer-rokitansky-kuster-hauser syndrome	11.6	GJB1, OTC, AFF2
13	factor viii deficiency	5.9
14	properdin deficiency	5.9
15	allan-herndon-dudley syndrome	5.9

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to x-linked disease:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	7.2	ZFX, CHM, GJB1, OTC, PDHA1, AFF2
2	nervous system phenotype	MP:0003631	7.1	ZFX, CHM, GJB1, OTC, PDHA1, AFF2
3	growth/size phenotype	MP:0005378	6.9	AFF2, PDHA1, OTC, GJB1, CHM, ZFX

Articles related to x-linked disease:

id	Title	Authors	Year	Affiliating Genes
1	Analysis of gap junction assembly using mutated connexins detected in Charcot-Marie-Tooth X-linked disease. (10646523)	Martin P.E.... Evans W.H.	2000	GJB1
2	Transcription map of Xq27: candidates for several X-linked diseases. (10198160)	Zucchi I.... Mumm S.	1999	AFF2, FRAXE
3	Preimplantation prevention of X-linked disease: relia ble and rapid sex determination of single human cells by restriction analysis o f simultaneously amplified ZFX and ZFY sequences. (8401500)	Chong S.S.... Hughes M.R.	1993	ZFX
4	X chromosome inactivation and the diagnosis of X linked disease in females. (8097254)	Brown R.M.... Brown G.K.	1993	PDHA1
5	Carrier detection in a partially dominant X-linked disease: ornithine transcarbamylase deficiency. (2298453)	Pelet A.... Munnich A.	1990	OTC

Genes related to x-linked disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)	11.1	Summaries
2	CHM	choroideremia (Rab escort protein 1)	11.1	Summaries
3	FRAXE	fragile site, folic acid type, rare, fra(X)(q28) E	11.0	Publications
4	PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	11.0	Publications
5	ZFX	zinc finger protein, X-linked	11.0	Publications
6	OTC	ornithine carbamoyltransferase	11.0	Publications
7	GJB1	gap junction protein, beta 1, 32kDa	11.0	Publications
8	AFF2	AF4/FMR2 family, member 2	11.0	Publications

Compounds related to x-linked disease according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	carnitine32	9.4	OTC, PDHA1
2	acetyl-l-carnitine32	9.1	OTC, PDHA1