X-linked Nonsyndromic Deafness malady

MalaCards: X-linked Nonsyndromic Deafness, also known as complete hearing loss, is related to nonsyndromic deafness and sensorineural hearing loss. An important gene associated with X-linked Nonsyndromic Deafness is POU3F4 (POU class 3 homeobox 4), and among its related pathways is Axon guidance.

Aliases & Descriptions:

x-linked nonsyndromic deafness 6 8 complete hearing loss 43

x-linked deafness 6

Diseases related to x-linked nonsyndromic deafness by text searches and GeneDecks gene sharing:

(show top 50)    (show all 169)

id	Related Disease	Score	Top Affiliating Genes
1	nonsyndromic deafness	28.8	POU3F4, COL4A5
2	sensorineural hearing loss	27.1	TIMM8A, COL4A5, POU3F4
3	choroideremia	12.5	RPS6KA6, POU3F4
4	mental retardation syndrome	12.0	TIMM8A, COL4A5
5	hearing loss	11.5	POU3F4, TIMM8A, COL4A5
6	twinning	11.4	TIMM8A, COL4A5, POU3F4
7	deafness, x-linked 2	7.3
8	autosomal dominant nonsyndromic deafness	6.5
9	deafness with labyrinthine aplasia microtia and microdontia (lamm)	6.5
10	deafness-infertility syndrome	6.5
11	deafness, autosomal dominant 10	6.5
12	deafness, autosomal recessive 79	6.5
13	deafness, autosomal recessive 29	6.5
14	deafness, autosomal dominant 47	6.5
15	deafness, autosomal recessive 40	6.5
16	deafness, autosomal dominant 25	6.5
17	enchondromatosis dwarfism deafness	6.5
18	autosomal recessive nonsyndromic deafness	6.5
19	deafness x-linked, dfn3	6.5
20	dfnb61 nonsyndromic hearing loss and deafness	6.5
21	deafness, autosomal recessive 77	6.5
22	deafness, autosomal recessive 6	6.5
23	deafness, autosomal recessive 84	6.5
24	deafness, autosomal dominant 49	6.5
25	deafness, autosomal recessive 44	6.5
26	deafness, autosomal dominant 2a	6.5
27	familial deafness	6.5
28	caudal appendage deafness	6.5
29	deafness, autosomal dominant nonsyndromic sensorineural 17	6.5
30	deafness, autosomal recessive 49	6.5
31	deafness, autosomal recessive 36	6.5
32	deafness, autosomal recessive 8, childhood onset	6.5
33	deafness, autosomal recessive 12	6.5
34	deafness, autosomal dominant 5	6.5
35	deafness, autosomal recessive 45	6.5
36	deafness, congenital heart defects, and posterior embryotoxon	6.5
37	myoclonus cerebellar ataxia deafness	6.5
38	chudley-mccullough syndrome	6.5
39	deafness, autosomal dominant nonsyndromic sensorineural 22	6.5
40	deafness, autosomal recessive 23	6.5
41	deafness, neurosensory, without vestibular involvement, autosomal dominant	6.5
42	deafness, autosomal recessive 10, congenital	6.5
43	deafness, x-linked 1, progressive	6.5
44	deafness, autosomal dominant 52	6.5
45	deafness, neurosensory, autosomal recessive 46	6.5
46	deafness, autosomal dominant 23	6.5
47	nonsyndromic hearing loss and deafness, mitochondrial	6.5
48	cleft palate colobomata radial synostosis deafness	6.5
49	deafness, autosomal dominant nonsyndromic sensorineural 23	6.5
50	deafness, autosomal dominant 28	6.5

Approved drugs:

Drug clinical trials:

Articles related to x-linked nonsyndromic deafness:

id	Title	Authors	Year	Affiliating Genes
1	Deletion of and novel missense mutation in POU3F4 in 2 families segregating X-linked nonsyndromic deafness. (16365218)	Vore A.P.... Smith R.J.	2005	POU3F4

Genes related to x-linked nonsyndromic deafness according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	POU3F4	POU class 3 homeobox 4	11.0	Publications
2	TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)	11.0
3	COL4A5	collagen, type IV, alpha 5	11.0
4	RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	11.0	Disorders

Pathways related to x-linked nonsyndromic deafness according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Axon guidance38	9.1	RPS6KA6, COL4A5

Biological processes related to x-linked nonsyndromic deafness according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon guidance	GO:007411	9.1	RPS6KA6, COL4A5