Xeroderma Pigmentosum malady

NIH Rare Diseases: Xeroderma pigmentosum (XP) is an inherited condition characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight. This condition mostly affects the eyes and areas of skin exposed to the sun. Some affected individuals also have problems involving the nervous system. Symptoms typically develop in infancy or early childhood. Xeroderma pigmentosum is caused by mutations in genes that are involved in repairing damaged DNA. Inherited mutations in at least eight genes have been identified. The condition is inherited in an autosomal recessive manner.³⁰

MalaCards: Xeroderma Pigmentosum, also known as desanctis-cacchione syndrome, is related to xeroderma pigmentosum, group c and xeroderma pigmentosum, group a. An important gene associated with Xeroderma Pigmentosum is XPC (xeroderma pigmentosum, complementation group C), and among its related pathways are Dual incision reaction in GG-NER and Formation of incision complex in GG-NER. The compounds 8-oxoguanine and egcg have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Genetics Home Reference: Xeroderma pigmentosum, which is commonly known as XP, is an inherited condition characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight. This condition mostly affects the eyes and areas of skin exposed to the sun. Some affected individuals also have problems involving the nervous system.¹⁷

Wikipedia: Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder of DNA repair in which the...⁴⁴ more...

OMIM: 278800

GeneReviews summary for xp

Aliases & Descriptions:

xeroderma pigmentosum 6 7 44 15 30 16 17 8 33 32 desanctis-cacchione syndrome 15 16 17 xp 30 16 17 de sanctis-cacchione syndrome 30 33

xeroderma pigmentosa 30 16 xerodermic idiocy 30 des syndrome 43 xeroderma 43

Disease types for xeroderma pigmentosum family:

xeroderma pigmentosum type 7	xeroderma pigmentosum, type 1
xeroderma pigmentosum, type 2	xeroderma pigmentosum, type 3
xeroderma pigmentosum, type 5	xeroderma pigmentosum, type 6
xeroderma pigmentosum, type 9

Diseases related to xeroderma pigmentosum by text searches and GeneDecks gene sharing:

(show top 50)    (show all 576)

id	Related Disease	Score	Top Affiliating Genes
1	xeroderma pigmentosum, group c	38.6	RECQL, RAD23A, RAD23B, UVRAG, XPC, CETN2
2	xeroderma pigmentosum, group a	38.2	RECQL4, PCNA, LMNA, XPA, XPC, MSSE
3	xeroderma pigmentosum, group d	37.1	XRCC1, XRCC4, XPC, ERCC2
4	xeroderma pigmentosum, group g	36.3	FEN1, EXO1, ERCC5, GEN1
5	xeroderma pigmentosum, group b	35.0	BCR, ERCC2, ERCC3, POLR2L
6	xeroderma pigmentosum, group f	34.9	ERCC1, ERCC4, OGG1
7	cockayne syndrome	33.0	ZNF830, PCNA, GCGR, RBX1, BRCA1, BRIP1
8	ovarian cancer	31.9	BRCA1, ATR, MRE11A, CDKN2A, CDK7, CDK4
9	neurologic diseases	31.2	PARP1, XPA, GSTT1, ERCC4, TBP, ABCA1
10	breast cancer	31.2	BRCA1, UBC, CDK4, CYP1A1, ODC1, CRAT
11	basal cell carcinoma	31.2	BCL2, BAX, XRCC1, XRCC3, XPA, MMP1
12	multiple self healing squamous epithelioma	31.0	XPA, MSSE, FANCC, PTCH1
13	progeria	31.0	LMNA, XPA, GTF2H4, ERCC1, ERCC4, ERCC6
14	nevoid basal cell carcinoma syndrome	30.9	PCNA, XPA, MC1R, FANCC, TP53, PTCH1
15	testicular cancer	30.3	XPC, ATM, MGMT, GSTT1, FAS, HPRT1
16	renal cell carcinoma	30.1	PCNA, RBX1, BAX, GSTT1, FAS, HSPA1A
17	skin carcinoma	29.7	CDK4, GSTT1, TP53, CPOX
18	albinism	29.4	XRCC1, XRCC3, XRCC4, XPC, GSR, GSTT1
19	dna topoisomerase i	28.5	PARP1, ATM, MRE11A, CDKN2A, CDK4, TP53
20	mental retardation syndrome	28.4	RBX1, ATR, ATM, HPRT1, ERCC2, TPH1
21	microcephaly	28.2	BRCA1, LIG4, XRCC4, ATR, ATM, MRE11A
22	squamous cell carcinoma	27.5	PCNA, RARG, PARP1, BCL2, BAX, XRCC1
23	systemic lupus erythematosus	27.4	BCR, APEX1, FAS, MBL2, F8, HPRT1
24	ataxia telangiectasia	27.3	PCNA, BRCA1, LIG4, LIG1, PARP1, BCL2
25	neurodegeneration	26.3	RBX1, PARP1, BCL2, UBC, BAX, ATM
26	skin cancer	26.1	PCNA, BRCA1, LIG4, BCL2, BAX, XRCC1
27	germ cell tumor	26.0	PCNA, RARG, PARP1, BCL2, BAX, XRCC1
28	renal carcinoma	25.9	PCNA, LMNA, BCL2, BCR, BAX, CDKN2A
29	keratosis	25.8	PCNA, LMNA, BCL2, CDKN2A, MMP1, GSTT1
30	laryngitis	25.7	RECQL4, PCNA, BRCA1, RAD23B, BCL2, BAX
31	fanconi's anemia	25.6	REV1, PCNA, BRCA1, BRIP1, LMNA, RAD23A
32	esophageal squamous cell carcinoma	25.5	PCNA, LMNA, PARP1, BCL2, BAX, XRCC1
33	cataract	25.4	RECQL4, PCNA, LMNA, PARP1, XRCC1, GSR
34	anemia	25.4	REV1, PCNA, BRCA1, BRIP1, LMNA, RAD23A
35	glioblastoma	25.3	PARP1, BAX, CDKN2A, CDK4, MGMT, TP53
36	synovial sarcoma	25.3	PCNA, BCL2, BAX, XRCC4, CDKN2A, CDK4
37	benign tumors	25.1	PCNA, GSR, FAS, CAT, HMGA1, TP53
38	melanoma	24.7	PCNA, RBX1, BRCA1, LMNA, RAD23A, PARP1
39	seizures	24.7	PARP1, MT2A, MMP1, IMMT, HSPA1A, CALB2
40	leiomyoma	24.6	PCNA, BRCA1, PARP1, BCL2, BAX, XRCC1
41	herpes simplex	24.5	REV3L, PCNA, LMNA, LIG4, BCL2, UNG
42	ataxia	24.4	PCNA, BRCA1, RAD23A, RAD23B, LIG4, LIG1
43	meningioma	24.3	RECQL4, REV1, PCNA, BRIP1, RAD54L, LIG4
44	graves' disease	24.3	BCL2, BAX, XRCC1, GSR, GSTT1, APEX1
45	esophagitis	24.3	REV1, REV3L, PCNA, BRCA1, LMNA, RAD23B
46	esophageal cancer	24.3	PCNA, RAD23B, PARP1, BCL2, BAX, MT2A
47	ovarian carcinoma	24.1	REV1, REV3L, PCNA, BRCA1, RARG, PARP1
48	epithelial ovarian cancer	23.9	BRCA1, BRIP1, LIG4, LIG1, PARP1, BCL2
49	lung adenocarcinoma	23.3	PCNA, PARP1, BCL2, BCR, UBC, BAX
50	nasopharyngitis	23.3	PCNA, PARP1, BCL2, UBC, BAX, MT2A

Clinical features from OMIM: 278800

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to xeroderma pigmentosum:

²²

MGI Mouse Phenotypes related to xeroderma pigmentosum:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	BRCA1, RARG, RAD23B, PSAP, CUL4A, ERCC1
2	craniofacial phenotype	MP:0005382	9.9	ERCC3, TP73, PTCH1, SSBP3, SMO, TDG
3	respiratory system phenotype	MP:0005388	9.7	ADA, SIRT1, ABCA1, SMO, TPH1, HPRT1
4	liver/biliary system phenotype	MP:0005370	9.3	FANCC, F11, HPRT1, ERCC4, ERCC6, TP53
5	pigmentation phenotype	MP:0001186	9.2	HPRT1, ERCC2, TP53, PTCH1, PTEN, HELLS
6	reproductive system phenotype	MP:0005389	9.2	ZNF830, GCGR, BRCA1, LMNA, RARG, RAD23B
7	adipose tissue phenotype	MP:0005375	9.1	ERCC6, TP53, TPH1, PTEN, NQO1, HELLS
8	digestive/alimentary phenotype	MP:0005381	9.0	HPRT1, ERCC5, PTCH1, PTEN, CUL4A, SMO
9	skeleton phenotype	MP:0005390	8.9	ERCC2, ERCC1, TP53, TP73, PTCH1, PTEN
10	limbs/digits/tail phenotype	MP:0005371	8.9	TP53, PTCH1, PTEN, SMO, HELLS, TDG
11	normal phenotype	MP:0002873	8.6	CYP1A1, PTCH1, CALB2, APEX1, FEN1, SSBP3
12	renal/urinary system phenotype	MP:0005367	8.3	ERCC1, PTCH1, PTEN, ABCA1, HELLS, PSAP
13	integument phenotype	MP:0010771	8.2	ATR, CD8A, CDK4, APRT, MC1R, FAS
14	behavior/neurological phenotype	MP:0005386	8.0	TPH1, TP73, ERCC6, ERCC1, ERCC3, ERCC2
15	hematopoietic system phenotype	MP:0005397	7.9	PCNA, BRCA1, RAD54L, LIG4, LIG1, BCL2
16	muscle phenotype	MP:0005369	7.8	TP53, TPH1, PTCH1, PTEN, CRAT, ABCA1
17	vision/eye phenotype	MP:0005391	7.8	TP73, TP53, ERCC6, ERCC8, ERCC2, PTCH1
18	tumorigenesis	MP:0002006	7.5	POLD1, POLE, POLH, POLI, SIRT1, GADD45A
19	immune system phenotype	MP:0005387	7.5	CUL4A, NQO1, RPA1, ABCA1, PSAP, PRKDC
20	embryogenesis phenotype	MP:0005380	7.5	GADD45A, POLD1, CSNK2B, TDG, HELLS, SMO
21	nervous system phenotype	MP:0003631	7.5	TP73, ERCC6, ERCC8, ERCC2, HPRT1, CALB2
22	hearing/vestibular/ear phenotype	MP:0005377	7.3	TP73, SMO, ABCB1, PSAP, PRKDC, SOD1
23	cardiovascular system phenotype	MP:0005385	6.0	SMO, CYP1A1, DDB1, TBP, PTEN, PTCH1
24	growth/size phenotype	MP:0005378	5.3	TP53, PRKDC, CSNK2B, SIRT1, ADA, GADD45A
25	mortality/aging	MP:0010768	4.5	POLD1, POLE, SIRT1, ADA, GADD45A, CSNK2B
26	homeostasis/metabolism phenotype	MP:0005376	4.1	ERCC5, HELLS, TDG, TALDO1, PSAP, PRKDC
27	cellular phenotype	MP:0005384	3.7	RAD23B, LIG4, LIG1, PARP1, BCL2, BCR

Articles related to xeroderma pigmentosum:

(show top 50)    (show all 303)

id	Title	Authors	Year	Affiliating Genes
1	Xeroderma pigmentosum skin: an immune privilege site for tumor development. (19719835)	Abid K.... Hamzaoui K.	2010	BCL2, BAX, FAS
2	Catalase overexpression reduces UVB-induced apoptosis in a human xeroderma pigmentosum reconstructed epidermis. (18202716)	Rezvani H.R.... Taieb A.	2008	CAT, XPC
3	Polymorphisms of the DNA repair gene xeroderma pigmentosum groups A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China. (17653764)	Guo W.... Dong X.J.	2008	XPC, XPA
4	Xeroderma pigmentosum genes: functions inside and out side DNA repair. (18174245)	Sugasawa K.	2008	POLH
5	Molecular analysis of DNA polymerase eta gene in Japanese patients diagnosed as xeroderma pigmentosum variant type. (17344931)	Tanioka M.... Nishigori C.	2007	POLH
6	In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation. (17682058)	Yasuda G.... Sugasawa K.	2007	XPC
7	The structure of the human centrin 2-xeroderma pigmentosum group C protein complex. (16627479)	Thompson J.R.... Kumar R.	2006	XPC, CETN2
8	Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome. (16947863)	Oh K.-S.... Kraemer K.H.	2006	ERCC3
9	Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches. (17176115)	Yang Z.... Zou Y.	2006	XPA
10	Xeroderma pigmentosum group E and DDB2, a smaller subunit of damage-specific DNA binding protein: proposed classification of xeroderma pigmentosum, Cockayne syndrome, and ultraviolet-sensitive syndrome. (16325378)	Itoh T.	2006	DDB2, SSBP3
11	Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects. (15744458)	Ridley A.J.... Jones C.J.	2005	XPC, ERCC8
12	Common polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not associated with breast cancer risk. (16030124)	Kuschel B.... Pharoah P.D.	2005	ERCC2
13	Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome. (16135823)	Theron T.... Lehmann A.R.	2005	ERCC2
14	Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. (15964821)	Nishi R.... Hanaoka F.	2005	XPC, RAD23B, CETN2
15	Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells. (12948486)	Zhou N.Y.... O'Connor T.R.	2003	XPC
16	Cloning and expression of xeroderma pigmentosum compl ementation group A cDNA and the identification of its recombinant protein. (12947563)	Yang Y.... Zhu X.	2003	XPA
17	Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. (12396616)	Muotri A.R.... Menck C.F.	2002	XPC
18	Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients. (12060391)	Emmert S.... Kraemer K.H.	2002	ERCC5
19	Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. (12376498)	Park J.Y.... Jung T.H.	2002	XPA
20	The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases. (11156600)	Lehmann A.R.	2001	ERCC2
21	Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant. (11181443)	Bullock S.K.... Cordeiro-Stone M.	2001	POLH
22	The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. (11564859)	Nag A.... Raychaudhuri P.	2001	CUL1, UBC, DDB1
23	Xeroderma pigmentosum complementation group A protein acts as a processivity factor. (10814539)	Lambert M.W.... Yang L.	2000	XPA
24	UV-specific mutations of the human patched gene in basal cell carcinomas from normal individuals and xeroderma pigmentosum patients. (10838143)	Daya-Grosjean L.... Sarasin A.	2000	PTCH1
25	Functional studies on the interaction between human replication protein A and Xeroderma pigmentosum group A complementing protein (XPA). (10340474)	Lee B.E.... Kim D.K.	1999	RPA1, RPA2, XPA
26	Hypoglycinaemia and psychomotor delay in a child with xeroderma pigmentosum. (10604143)	Quackenbush E.J.... Levy H.L.	1999	XPC
27	Subnuclear distribution of DNA topoisomerase I and Bax protein in normal and xeroderma pigmentosum fibroblasts after irradiation with UV light and gamma rays or treatment with topotecan. (10235474)	Thielmann H.W.... Staab H.J.	1999	TOP1
28	The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein. (9874796)	Takeda N.... Maru Y.	1999	BCR, ERCC3
29	Complete restoration of normal DNA repair characteristics in group F xeroderma pigmentosum cells by over-expression of transfected XPF cDNA. (9472693)	Yagi T.... Takebe H.	1998	ERCC4
30	Characterization of molecular defects in Xeroderma pigmentosum group F in relation to its clinically mild symptoms. (9580660)	Matsumura Y.... Takebe H.	1998	ERCC4
31	Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene. (9238033)	Taylor E.M.... Lehmann A.R.	1997	ERCC2
32	Mutations in the XPD gene leading to Xeroderma pigmentosum symptoms. (9101292)	Kobayashi T.... Tanaka K.	1997	ERCC2
33	Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells. (8538642)	Hwang B.J.... Chu G.	1996	DDB1
34	A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. (8663148)	Hwang J.R.... Egly J.M.	1996	ERCC2, ERCC3
35	Xeroderma pigmentosum group F caused by a defect in a structure- specific DNA repair endonuclease. (8797827)	Sijbers A.M.... Wood R.D.	1996	ERCC4
36	Two novel splicing mutations in the XPA gene in patients with group A xeroderma pigmentosum. (8595429)	Satokata I.... Tanaka K.	1995	XPA
37	Defects in the DNA repair and transcription gene ERCC2 in the cancer- prone disorder xeroderma pigmentosum group D. (7585650)	Takayama K.... Weber C.A.	1995	ERCC2
38	Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome. (7825573)	Broughton B.C.... Lehmann A.R.	1995	ERCC2
39	Human Xeroderma pigmentosum group G gene encodes a DNA endonuclease. (8078765)	Habraken Y.... Prakash S.	1994	ERCC5
40	Analysis of cells harboring a putative DNA repair gene reveals a lack of evidence for a second independent xeroderma pigmentosum group A correcting gene. (7519740)	Jones C.J.... Wood R.D.	1994	XPA
41	Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3. (8304337)	Vermeulen W.... Weeda G.	1994	ERCC3
42	Human Xeroderma pigmentosum group D gene encodes a DNA helicase. (8413672)	Sung P.... Prakash S.	1993	ERCC2
43	UV-induced mutations in a shuttle vector replicated in repair deficient trichothiodystrophy cells differ with those in genetically-related cancer prone xeroderma pigmentosum. (8392442)	Madzak C.... Sarasin A.	1993	CAT
44	High prevalence of the point mutation in exon 6 of the xeroderma pigmentosum group A-complementing (XPAC) gene in xeroderma pigmentosum group A patients in Tunisia. (8105686)	Nishigori C.... Takebe H.	1993	XPA
45	Molecular basis of group A Xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene. (1339397)	Satokata I.... Okada Y.	1992	XPA
46	Two types of proliferating cell nuclear antigen (PCNA) complex formation in quiescent normal and xeroderma pigmentosum group A fibroblasts following ultraviolet light (uv) irradiation. (1353458)	Miura M.... Takasaki Y.	1992	PCNA
47	Correction of Xeroderma pigmentosum complementation group D mutant cell phenotypes by chromosome and gene transfer: involvement of the human ERCC2 DNA repair gene. (1729695)	Fletjer W.L.... Schultz R.A.	1992	ERCC2
48	Induction of the 72-kD heat shock protein in xeroderma pigmentosum complementation group A fibroblasts. (1431227)	Muramatsu T.... Ohnishi T.	1992	HSPA1A
49	Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients. (1801654)	Schallreuter K.U.... Wood J.M.	1991	GSR, CAT, PRDX5
50	Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene. (1918083)	Miura N.... Okada Y.	1991	XPA

Genes related to xeroderma pigmentosum according to GeneCards:

(show top 50)    (show all 130)

id	Symbol	Description	Score	GeneCards Section Context
1	XPC	xeroderma pigmentosum, complementation group C	11.1	Publications, Summaries, Transcripts, Aliases & Descriptions (show all 5 sections) Orthologs
2	ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	11.1	Aliases & Descriptions, Orthologs, Summaries, Publications
3	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.1	Publications, Summaries, Domains & Families, Orthologs (show all 5 sections) Aliases & Descriptions
4	ERCC3	excision repair cross-complementing rodent repair deficiency, complementation group 3	11.1	Summaries, Orthologs, Domains & Families, Aliases & Descriptions (show all 5 sections) Publications
5	ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2	11.1	Summaries, Orthologs, Aliases & Descriptions, Domains & Families (show all 5 sections) Publications
6	XPA	xeroderma pigmentosum, complementation group A	11.1	Publications, Transcripts, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
7	DDB2	damage-specific DNA binding protein 2, 48kDa	11.1	Publications, Summaries, Aliases & Descriptions
8	DDB1	damage-specific DNA binding protein 1, 127kDa	11.1	Summaries, Aliases & Descriptions, Publications
9	POLH	polymerase (DNA directed), eta	11.1	Summaries, Orthologs, Publications, Aliases & Descriptions
10	RAD23B	RAD23 homolog B (S. cerevisiae)	11.1	Summaries, Publications
11	UVRAG	UV radiation resistance associated gene	11.1	Summaries, Publications
12	TP53	tumor protein p53	11.0	Publications
13	CETN2	centrin, EF-hand protein, 2	11.0	Publications
14	RECQL	RecQ protein-like (DNA helicase Q1-like)	11.0	Publications
15	RAD23A	RAD23 homolog A (S. cerevisiae)	11.0	Publications
16	ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	11.0	Publications
17	RPA2	replication protein A2, 32kDa	11.0	Publications
18	PSAP	prosaposin	11.0	Publications
19	POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	11.0	Publications
20	FEN1	flap structure-specific endonuclease 1	11.0	Domains & Families, Orthologs
21	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	11.0	Publications
22	PTCH1	patched 1	11.0	Publications
23	RPA1	replication protein A1, 70kDa	11.0	Publications
24	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
25	BCR	breakpoint cluster region	11.0	Publications
26	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
27	TOP1	topoisomerase (DNA) I	11.0	Publications
28	PCNA	proliferating cell nuclear antigen	11.0	Publications
29	MSSE	multiple self-healing squamous epithelioma	11.0	Publications
30	RECQL4	RecQ protein-like 4	11.0	Publications
31	GEN1	Gen endonuclease homolog 1 (Drosophila)	11.0	Domains & Families
32	GTF2H2	general transcription factor IIH, polypeptide 2, 44kDa	11.0	Publications
33	ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	11.0	Publications
34	TDG	thymine-DNA glycosylase	11.0	Publications
35	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	11.0	Publications
36	CPOX	coproporphyrinogen oxidase	11.0	Publications
37	POLI	polymerase (DNA directed) iota	11.0	Publications
38	CUL4A	cullin 4A	11.0	Publications
39	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0	Publications
40	RAD54L	RAD54-like (S. cerevisiae)	11.0
41	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
42	LIG4	ligase IV, DNA, ATP-dependent	11.0
43	PVALB	parvalbumin	11.0	Publications
44	HMGA1	high mobility group AT-hook 1	11.0	Publications
45	MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	11.0	Publications
46	TPH1	tryptophan hydroxylase 1	11.0	Publications
47	EXO1	exonuclease 1	11.0	Domains & Families
48	HELLS	helicase, lymphoid-specific	11.0	Publications
49	CALB2	calbindin 2	11.0	Publications
50	LIG1	ligase I, DNA, ATP-dependent	11.0

Pathways related to xeroderma pigmentosum according to GeneDecks:

(show top 50)    (show all 68)

id	Pathway	Score	Top Affiliating Genes
1	Dual incision reaction in GG-NER38	11.1	RAD23B, XPA, XPC, ERCC5, ERCC1, ERCC4
2	Formation of incision complex in GG-NER38	10.8	ERCC3, ERCC2, GTF2H4, GTF2H2, GTF2H1
3	Fluoropyrimidine Pathway, Pharmacodynamics34	10.8	DHFR, TDG, TP53, ERCC2, XRCC3
4	DNA damage_DNA-damage-induced responses41	10.6	PRKDC, ATM, ATR, BRCA1
5	DNA damage DNA-damage-induced responses10	10.6	PRKDC, ATM, ATR, BRCA1
6	Transcription P53 signaling pathway10	10.6	ATR, CDKN2A, GTF2H1, GTF2H2, GTF2H4, GTF2H5
7	Nucleotide Excision Repair Pathway36	10.6	ERCC1, ERCC4, ERCC6, RPA2, POLD1, POLE
8	Mismatch repair20	10.6	POLD1, RPA2, RPA1, EXO1, LIG1, PCNA
9	Basal transcription factors20	10.6	TBP, ERCC3, ERCC2, CCNH, GTF2H5, GTF2H4
10	DNA Damage3	10.6	DDB1, DDB2, RPA1, RPA2, PRKDC, GADD45A
11	DNA Damage Induced 14-3-3Sigma Signaling36	10.5	TP53, ATM, ATR, RAD1, BRCA1
12	Assembly of RNA Polymerase-II Initiation Complex36	10.5	POLR2L, TBP, GTF2H5, GTF2H4, GTF2H2, GTF2H1
13	Non-homologous end-joining20	10.5	POLM, PRKDC, FEN1, MRE11A, XRCC4, LIG4
14	Mismatch Repair in Eukaryotes36	10.4	POLE, POLD1, RPA2, EXO1, FEN1, PCNA
15	Transcription of mRNA36	10.4	POLR2L, TBP, GTF2H5, GTF2H4, GTF2H2, GTF2H1
16	GADD45 Pathway36	10.4	GADD45A, TP53, CDK4, CDK7, ATM, ATR
17	Transcription_Ligand-Dependent Transcription of Retinoid-Target genes41	10.4	CDK7, GTF2H1, GTF2H2, GTF2H4, GTF2H5, CCNH
18	Transcription Ligand-Dependent Transcription of Retinoid-Target genes10	10.4	POLR2L, SAP130, CDK7, GTF2H1, GTF2H2, GTF2H4
19	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.4	GADD45A, CDK4, ATM, ATR
20	Resolution of AP sites via the single-nucleotide replacement pathway38	10.3	XRCC1, APEX1, TDG, OGG1
21	DNA damage_Role of Brca1 and Brca2 in DNA repair41	10.3	BRCA1, BRIP1, XPC, ATR, ATM, MRE11A
22	DNA damage Role of Brca1 and Brca2 in DNA repair10	10.3	POLR2L, PCNA, BRCA1, BRIP1, XPC, ATR
23	Homologous recombination20	10.3	POLD1, RPA2, RPA1, MRE11A, XRCC3, RAD54L
24	Chks in Checkpoint Regulation36	10.3	TP53, MRE11A, ATM, ATR, RAD1, BRCA1
25	ATM Pathway36	10.3	GADD45A, TP73, TP53, MRE11A, ATM, BRCA1
26	DNA replication20	10.2	POLE, POLD1, POLA1, RPA2, RPA1, FEN1
27	Nucleotide excision repair20	10.2	PCNA, RBX1, RAD23A, RAD23B, LIG1, POLE
28	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	10.2	MT2A, GSTT1, NQO1, SOD1
29	Cyclins and Cell Cycle Regulation36	10.1	TP53, CCNH, CDK4, CDK7, CDKN2A, ATM
30	Cell Cycle, Mitotic38	10.1	POLE, DHFR, RPA2, RPA1, CCNH, FEN1
31	Transcription_P53 signaling pathway41	10.1	BCL2, XPA, XPC, ATR, ATM, CDKN2A
32	Dual incision reaction in TC-NER38	10.1	ERCC6, ERCC8, XAB2
33	DNA damage_NHEJ mechanisms of DSBs repair41	10.0	SIRT1, POLM, CSNK2B, CSNK2A2, PRKDC, FEN1
34	DNA damage NHEJ mechanisms of DSBs repair10	10.0	BRCA1, LIG4, XRCC4, MRE11A, FEN1, PRKDC
35	Fanconis Anaemia Pathway36	9.9	FANCC, MRE11A, ATR, UBC, BRCA1
36	DNA Repair Mechanisms36	9.9	PCNA, ERCC3, ERCC5, ERCC1, ERCC4, ERCC6
37	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.9	SOD1, ABCB1, NQO1, TP53, ERCC2, CAT
38	BRCA1 Pathway36	9.9	GADD45A, HELLS, TP53, FANCC, MRE11A, ATM
39	Cell cycle Transition and termination of DNA replacation10	9.9	POLE, PCNA, BRCA1, LIG1, CDK4, FEN1
40	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.9	GADD45A, TP53, CDK4, ATM, ATR, UBC
41	Cell cycle20	9.9	CCNH, TP53, CUL1, PRKDC, GADD45A, CDK4
42	RAR-Gamma-RXR-Alpha Degradation36	9.9	TBP, GTF2H5, GTF2H4, GTF2H2, GTF2H1, CDK7
43	Cell cycle_Transition and termination of DNA replication41	9.7	BRCA1, LIG1, UBC, FEN1, TOP1, POLA1
44	Base excision repair20	9.7	PCNA, LIG1, PARP1, UNG, XRCC1, FEN1
45	Cell Cycle / Checkpoint Control3	9.6	TP53, TP73, RPA1, RPA2, PRKDC, RRM1
46	HIF1Alpha Pathway36	9.5	TP53, HSPA1A, APEX1, CDKN2A, UBC, RBX1
47	p53 signaling pathway20	9.2	GADD45A, DDB2, PTEN, TP73, TP53, FAS
48	Selected targets of p5310	8.7	POLH, ABCB1, TP53, MGMT, CDK4, BAX
49	p53 Signaling36	8.4	TP53, PTEN, SIRT1, GADD45A, CDK4, ATM
50	Pathways in cancer20	8.3	SMO, PTEN, PTCH1, TP53, FAS, MMP1

Compounds related to xeroderma pigmentosum according to GeneDecks:

(show top 50)    (show all 266)

id	Compound	Score	Top Affiliating Genes
1	8-oxoguanine32	10.7	XRCC1, POLR2L, OGG1, HELLS, ERCC6, HPRT1
2	egcg32	10.6	CAT, SOD1, TOP1, ODC1
3	hydroxyurea32 9 9	12.6	RRM1, POLR2L, RECQL4, PCNA, BRCA1, DHFR
4	aphidicolin32	10.5	DHFR, TOP1, RPA2, CRAT, TP53, HPRT1
5	platinum32	10.3	TOP1, POLH, PRDX5, ERCC1, HMGB1, GSTT1
6	bpde32	10.3	RPA1, HPRT1, TBP, BRCA1, ATM, GSTT1
7	oxaliplatin32 34 9 9	13.3	TP53, ERCC1, ERCC2, HPRT1, FAS, GSTT1
8	thymine32 18	11.3	UNG, APEX1, SSBP3, HELLS, TDG, OGG1
9	vincristine32 34 9 9	13.3	ADA, CRAT, ODC1, F8, MGMT
10	benzo(a)pyrene32	10.3	XPA, XRCC1, BRCA1, XPC, HELLS, NQO1
11	n acetylcysteine32	10.1	GADD45A, PRDX5, NQO1, CRAT, ODC1, TP53
12	cyclophosphamide32 34 9 9	13.1	F8, MBL2
13	methylmethanesulfonate32	10.1	PCNA, BRCA1, PARP1, GADD45A, OGG1, HELLS
14	adenine32 9 18 9	12.9	CRAT, ODC1, TBP, HPRT1, FANCC, APRT
15	melphalan32 9 9	11.9	ERCC2, FANCC, APRT, MGMT, XRCC3, ERCC3
16	folate32	9.8	GSTT1, NQO1, ODC1, ERCC2, HPRT1, MC1R
17	mitomycin c32	9.7	XRCC3, BRCA1, PCNA, XPA, ATM, DHFR
18	bcnu32	9.7	PRDX5, TOP1, NQO1, TP53, ERCC1, ERCC2
19	ascorbic acid32 18	10.6	HPRT1, FAS, APEX1, GSTT1, CDK4, XRCC1
20	h2o232	9.2	HELLS, NQO1, CRAT, ODC1, TPH1, ERCC6
21	caffeine32 34 9 18 9	13.2	BRCA1, RPA2, CYP1A1, GADD45A, ADA, LIG1
22	cysteine32	9.2	DDB1, TBP, PTEN, TPH1, HMGB1, APEX1
23	estrogen32	9.2	BRCA1, RARG, MT2A, CDK7, MMP1, MGMT
24	nitric oxide32 9 18 9	12.0	CALB2, HMGB1, CPOX, OGG1, PRDX5, ABCA1
25	arginine32	9.0	ADA, CPOX, POLR2L, CSNK2A2, SOD1, PSAP
26	zinc32 18	9.9	XRCC1, PTCH1, TBP, DDB1, SSBP3, CRAT
27	cytarabine32 34 9 9	11.5	ATR, BAX, BCR, BCL2, LIG1, PCNA
28	indole-3-carbinol32	8.2	TP53, CDK4, NQO1, PTEN, CYP1A1, CRAT
29	thymidylate32	8.1	ERCC1, ERCC2, HPRT1, FAS, MGMT, CDK4
30	progesterone32 42 9 18 9	12.1	BRCA1, BCL2, CDKN2A, CSNK2A2, CDK4, MGMT
31	adriamycin32	8.0	SOD1, OGG1, PRDX5, BCL2, BRCA1, BAX
32	carboplatin32 34 9 9	10.9	ABCB1, TP53, ERCC1, BCL2, HMGB1, GSR
33	resveratrol32 9 18 9	10.9	FAS, BAX, BCL2, BRCA1, CDK4, TP53
34	gemcitabine32 34 9 9	10.9	BAX, BCL2, PARP1, BRCA1, PCNA, APEX1
35	5fluorouracil32	7.7	TDG, CDKN2A, XRCC1, BAX, UNG, BCL2
36	doxorubicin32 34 9 9	10.6	ERCC1, CAT, FAS, GSTT1, GSR, MGMT
37	oligonucleotide32	7.6	RPA1, RRM1, RPA2, ABCA1, HELLS, PSAP
38	curcumin32	7.4	ODC1, TP53, HPRT1, CAT, MGMT, MMP1
39	paraffin32	7.4	CDKN2A, ATM, CDK4, MMP1, MGMT, APEX1
40	camptothecin32 42 9 9	10.2	NQO1, BCL2, PARP1, BRCA1, PCNA, BAX
41	retinoic acid32 42 18	9.1	MMP1, MGMT, FEN1, FAS, CCNH, HMGB1
42	paclitaxel32 34 9 9	10.0	PTEN, TP53, ERCC1, ERCC2, CALB2, FAS
43	etoposide32 42 9 9	9.9	PCNA, LIG1, PRDX5, ATR, ATM, MGMT
44	arsenite32 18	7.8	GADD45A, POLR2L, SOD1, OGG1, DHFR, ABCB1
45	serine32	6.8	RPA2, F11, F8, CCNH, MBL2, FAS
46	genistein32 9 18 9	9.4	BAX, BCR, FAS, ATR, PARP1, BRCA1
47	quercetin32 42 9 18 9	10.4	NQO1, PARP1, ABCB1, BCL2, BAX, GADD45A
48	oxygen32 18	7.1	GADD45A, CPOX, OGG1, PRDX5, TALDO1, ABCA1
49	atp32	6.0	F8, ERCC6, MBL2, ERCC5, ERCC3, HMGB1
50	cisplatin32 34 9 9	8.7	CRAT, SSBP3, CYP1A1, DDB2, DDB1, TBP

Cellular components related to xeroderma pigmentosum according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	XPC complex	GO:071942	10.6	CETN2, XPC, RAD23B
2	holo TFIIH complex	GO:005675	10.6	ERCC5, ERCC3, ERCC2, CCNH, GTF2H4, GTF2H2
3	nucleotide-excision repair complex	GO:000109	10.5	POLD1, ERCC4, ERCC1, ERCC8
4	Cul4A-RING ubiquitin ligase complex	GO:031464	10.5	CUL4A, DDB1, ERCC8, RBX1
5	nonhomologous end joining complex	GO:070419	10.4	PRKDC, XRCC4, LIG4
6	protein complex	GO:043234	10.3	SSBP3, DDB2, TP53, ERCC8, CDKN2A, UVRAG
7	cyclin-dependent protein kinase activating kinase holoenzyme complex	GO:019907	10.2	PUF60, ERCC2, CCNH
8	DNA-dependent protein kinase-DNA ligase 4 complex	GO:005958	10.1	PRKDC, XRCC4, LIG4
9	PML body	GO:016605	10.0	SIRT1, TDG, RPA2, RPA1, PTEN, TP53
10	nucleolus	GO:005730	8.4	RPA2, RPA1, TP53, ERCC6, ERCC1, TOP1
11	cytoplasm	GO:005737	6.9	RPA1, NQO1, DDB1, TBP, PTEN, TP53
12	nucleoplasm	GO:005654	6.7	PARP1, UBC, XRCC1, XRCC4, XPA, XPC
13	cytosol	GO:005829	6.1	CAT, HPRT1, HMGA1, TP53, TPH1, PTEN
14	nucleus	GO:005634	4.4	POLH, POLI, POLM, POLR2L, SIRT1, GADD45A

Biological processes related to xeroderma pigmentosum according to GeneDecks:

(show top 50)    (show all 75)

id	Name	GO ID	Score	Top Affiliating Genes
1	UV protection	GO:009650	10.9	ERCC4, ERCC1, ERCC5, ERCC2, CAT, MC1R
2	nucleotide-excision repair, DNA damage removal	GO:000718	10.9	GTF2H2, GTF2H1, CDK7, XPC, XPA, RAD23B
3	response to X-ray	GO:010165	10.7	ERCC6, ERCC1, ERCC8, XRCC4, LIG4
4	transcription elongation from RNA polymerase I promoter	GO:006362	10.7	GTF2H1, GTF2H2, GTF2H4, CCNH, ERCC2, ERCC3
5	termination of RNA polymerase I transcription	GO:006363	10.7	ERCC3, ERCC2, CCNH, GTF2H4, GTF2H2, GTF2H1
6	transcription initiation from RNA polymerase I promoter	GO:006361	10.7	GTF2H1, GTF2H2, GTF2H4, CCNH, ERCC2, ERCC3
7	transcription from RNA polymerase I promoter	GO:006360	10.7	ERCC3, CDK7, GTF2H1, GTF2H2, GTF2H4, CCNH
8	7-methylguanosine mRNA capping	GO:006370	10.6	POLR2L, ERCC3, ERCC2, CCNH, GTF2H4, GTF2H2
9	DNA ligation involved in DNA repair	GO:051103	10.6	LIG4, LIG1, XRCC4, HMGB1
10	response to UV	GO:009411	10.6	ERCC4, ERCC6, DDB2, POLD1, ERCC8, ERCC5
11	positive regulation of viral transcription	GO:050434	10.6	POLR2L, ERCC3, ERCC2, CCNH, GTF2H4, GTF2H2
12	DNA damage response, signal transduction resulting in induction of apoptosis	GO:008630	10.6	TP73, ERCC6, ATM, XPA, BRCA1
13	transcription elongation from RNA polymerase II promoter	GO:006368	10.6	POLR2L, TBP, ERCC3, ERCC2, CCNH, GTF2H4
14	double-strand break repair via homologous recombination	GO:000724	10.5	RPA2, RPA1, ERCC4, MRE11A, ATM, LIG1
15	DNA recombination	GO:006310	10.5	POLM, RPA1, ERCC1, HMGB1, EXO1, APEX1
16	nucleotide-excision repair, DNA gap filling	GO:006297	10.4	POLE, PCNA, LIG4, LIG1, RPA1, RPA2
17	multicellular organism growth	GO:035264	10.4	SMO, TP53, ERCC1, ERCC5, ERCC2, RARG
18	DNA strand elongation involved in DNA replication	GO:006271	10.4	POLD1, POLA1, RPA2, RPA1, FEN1, LIG1
19	replicative senescence	GO:090399	10.3	ATR, ATM, CDKN2A, TP53
20	nucleotide-excision repair	GO:006289	10.3	POLR2L, POLE, POLD1, OGG1, RPA2, RPA1
21	cellular response to ionizing radiation	GO:071479	10.3	GADD45A, SIRT1, TP53, MGMT, RAD1
22	transcription-coupled nucleotide-excision repair	GO:006283	10.3	POLR2L, POLE, POLD1, RPA2, RPA1, CDK7
23	response to oxidative stress	GO:006979	10.3	NQO1, PRDX5, OGG1, SIRT1, ERCC6, ERCC1
24	telomere maintenance via semi-conservative replication	GO:032201	10.3	POLE, POLD1, POLA1, RPA2, RPA1, FEN1
25	telomere maintenance via recombination	GO:000722	10.3	POLE, POLD1, POLA1, RPA2, RPA1, FEN1
26	double-strand break repair via nonhomologous end joining	GO:006303	10.2	POLA1, PRKDC, MRE11A, XRCC4, LIG4
27	double-strand break repair	GO:006302	10.2	SOD1, PRKDC, RPA2, RPA1, TP53, ERCC1
28	positive regulation of DNA repair	GO:045739	10.1	SIRT1, ERCC8, APEX1, MGMT, BRCA1
29	cell cycle checkpoint	GO:000075	10.0	ERCC3, TP53, DDB1, RPA1, RPA2, ERCC2
30	DNA synthesis involved in DNA repair	GO:000731	10.0	SIRT1, POLH, POLE, POLD1, POLA1
31	T cell differentiation in thymus	GO:033077	10.0	PRKDC, TP53, XRCC4, BCL2, LIG4
32	proteasomal ubiquitin-dependent protein catabolic process	GO:043161	9.9	SIRT1, DDB1, ERCC8, RAD23B, RAD23A, RBX1
33	base-excision repair	GO:006284	9.9	POLD1, PCNA, LIG1, PARP1, UNG, OGG1
34	response to gamma radiation	GO:010332	9.8	PRKDC, TP53, ERCC6, XRCC4, BAX, BCL2
35	viral reproduction	GO:016032	9.7	CCNH, HMGA1, ERCC2, ERCC3, TBP, POLR2L
36	DNA replication	GO:006260	9.7	RECQL, HELB, RPA2, RPA1, FEN1, ATR
37	transcription from RNA polymerase II promoter	GO:006366	9.7	POLR2L, TBP, ERCC6, ERCC3, ERCC2, CCNH
38	telomere maintenance	GO:000723	9.7	POLE, POLD1, POLA1, PRKDC, RPA2, RPA1
39	virus-host interaction	GO:019048	9.5	TBP, DDB1, CUL1, CUL4A, TOP1, POLA1
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.5	ERCC3, TP53, TP73, SSBP3, SMO, PRKDC
41	neuron apoptotic process	GO:051402	9.4	TP53, FAS, ATM, BAX, BCL2, LIG4
42	G1 phase of mitotic cell cycle	GO:000080	9.4	CUL1, CCNH, CDK4, CDK7, CDKN2A, UBC
43	transcription initiation from RNA polymerase II promoter	GO:006367	9.3	POLR2L, TBP, ERCC3, ERCC2, CCNH, GTF2H4
44	response to toxin	GO:009636	9.3	NQO1, ERCC6, FAS, MGMT, XPA, BAX
45	response to DNA damage stimulus	GO:006974	9.2	SIRT1, TP73, TP53, ERCC8, MRE11A, ATM
46	S phase of mitotic cell cycle	GO:000084	9.1	RPA1, RPA2, POLA1, POLD1, POLE, CUL1
47	negative regulation of apoptotic process	GO:043066	9.0	SIRT1, PRDX5, SSBP3, PTEN, TP53, ERCC1
48	mitotic cell cycle	GO:000278	8.8	CCNH, CUL1, RPA1, RPA2, POLA1, POLD1
49	G1/S transition of mitotic cell cycle	GO:000082	8.7	CUL4A, RPA1, RPA2, POLA1, POLE, CUL1
50	DNA repair	GO:006281	7.4	DDB1, FEN1, MGMT, GTF2H4, GTF2H2, GTF2H1

Molecular functions related to xeroderma pigmentosum according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	single-stranded DNA binding	GO:003697	10.7	ERCC4, SSBP3, RPA1, RPA2, ERCC1, ERCC5
2	damaged DNA binding	GO:003684	10.6	FEN1, APEX1, HMGB1, ERCC3, ERCC1, ERCC4
3	DNA-dependent ATPase activity	GO:008094	10.6	ERCC6, ERCC8, ERCC3, ERCC2, CCNH, GTF2H4
4	RNA polymerase II carboxy-terminal domain kinase activity	GO:008353	10.6	ERCC3, ERCC2, CCNH, GTF2H4, GTF2H2, GTF2H1
5	endodeoxyribonuclease activity	GO:004520	10.4	ERCC4, ERCC5, APEX1, MRE11A
6	endonuclease activity	GO:004519	10.4	FEN1, APEX1, ERCC5, OGG1, GEN1
7	protein kinase activity	GO:004672	10.4	POLR2L, PRKDC, ERCC3, ERCC2, CCNH, GTF2H4
8	protein C-terminus binding	GO:008022	10.3	SIRT1, ERCC6, ERCC4, ERCC1, ERCC3, ERCC2
9	bubble DNA binding	GO:000405	10.2	ERCC5, XPC, RECQL4
10	protein N-terminus binding	GO:047485	10.0	ERCC6, TP53, RPA2, CSNK2A2, ERCC4, ERCC5
11	ATP-dependent DNA helicase activity	GO:004003	10.0	ERCC3, ERCC2, MRE11A, BRIP1, RECQL
12	DNA-directed DNA polymerase activity	GO:003887	9.8	POLM, POLI, POLH, POLE, POLD1, POLA1
13	4 iron, 4 sulfur cluster binding	GO:051539	9.6	POLE, POLD1, POLA1, ERCC2, BRIP1, REV3L
14	ubiquitin protein ligase binding	GO:031625	9.5	RBX1, BRCA1, BCL2, MC1R, TP53, CUL1
15	metal ion binding	GO:046872	9.4	TP73, RPA1, CSNK2B, POLA1, POLD1, POLH
16	transcription factor binding	GO:008134	9.2	TP73, TBP, PRKDC, CSNK2B, TP53, ERCC3
17	ATP binding	GO:005524	8.7	ABCA1, TP53, ERCC6, ERCC3, ABCB1, HELB
18	DNA binding	GO:003677	7.9	HELLS, DDB2, DDB1, TP53, ERCC6, ERCC3
19	protein binding	GO:005515	2.0	ERCC8, RPA1, RPA2, ABCA1, ABCB1, AHCYL1