XP
MCID: XRD001
MIFTS: 66

Xeroderma Pigmentosum (XP) malady

Genetic diseases, Rare diseases, Skin diseases, Fetal diseases, Cancer diseases categories
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Summaries for Xeroderma Pigmentosum

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NIH Rare Diseases:42 Xeroderma pigmentosum (xp) is an inherited condition characterized by an extreme sensitivity to ultraviolet (uv) rays from sunlight. this condition mostly affects the eyes and areas of skin exposed to the sun. some affected individuals also have problems involving the nervous system. symptoms typically develop in infancy or early childhood. xeroderma pigmentosum is caused by mutations in genes that are involved in repairing damaged dna. inherited mutations in at least eight genes have been identified. the condition is inherited in an autosomal recessive manner. last updated: 10/21/2010

MalaCards based summary: Xeroderma Pigmentosum, also known as desanctis-cacchione syndrome, is related to xeroderma pigmentosum, group d and xeroderma pigmentosum, group e, ddb-negative subtype. An important gene associated with Xeroderma Pigmentosum is XPC (xeroderma pigmentosum, complementation group C), and among its related pathways are RNA Polymerase I Promoter Escape and Cyclophosphamide Pathway, Pharmacodynamics. The compounds 2-acetylaminofluorene and ecteinascidin 743 have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and lung, and related mouse phenotypes are pigmentation and craniofacial.

Disease Ontology:8 An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has material basis in autosomal recessive inheritance of dna repair.

Genetics Home Reference:21 Xeroderma pigmentosum, which is commonly known as XP, is an inherited condition characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight. This condition mostly affects the eyes and areas of skin exposed to the sun. Some affected individuals also have problems involving the nervous system.

Wikipedia:65 Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder of DNA repair in which the... more...

Descriptions from OMIM:46 278720, 278740, 278780, 278750, 610651 278760, 278730, 278700 more

GeneReviews summary for xp

Aliases & Classifications for Xeroderma Pigmentosum

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Xeroderma Pigmentosum, Aliases & Descriptions:

Name: Xeroderma Pigmentosum 8 65 19 42 20 22 21 10 44
Desanctis-Cacchione Syndrome 19 21 62
 
Xp 42 21
Xeroderma Pigmentosa 42


Classifications:



External Ids:

Disease Ontology8 DOID:0050427
MeSH34 D014983

Related Diseases for Xeroderma Pigmentosum

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Diseases in the Xeroderma Pigmentosum, Variant Type family:

xeroderma pigmentosum Xeroderma Pigmentosum Type 7
Xeroderma Pigmentosum, Type 1 Xeroderma Pigmentosum, Type 2
Xeroderma Pigmentosum, Type 3 Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum, Type 6 Xeroderma Pigmentosum, Type 9
Xpa-Related Xeroderma Pigmentosum Ercc3-Related Xeroderma Pigmentosum
Xpc-Related Xeroderma Pigmentosum Ercc2-Related Xeroderma Pigmentosum
Ddb2-Related Xeroderma Pigmentosum Ercc4-Related Xeroderma Pigmentosum
Ercc5-Related Xeroderma Pigmentosum Polh-Related Xeroderma Pigmentosum
Ercc1-Related Xeroderma Pigmentosum

Diseases related to Xeroderma Pigmentosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1xeroderma pigmentosum, group d31.9ERCC3, ERCC2
2xeroderma pigmentosum, group e, ddb-negative subtype31.2DDB2, XPC
3lung cancer30.9ERCC1, ERCC2, TP53
4basal cell carcinoma30.9ERCC1, ERCC2, XPA, TP53
5melanoma30.5DDB2, TP53, XPC, ERCC5, ERCC2, ERCC1
6cockayne syndrome30.5XPA, XPC, DDB2, RAD23B, ERCC5, ERCC2
7testicular cancer30.4ERCC1, ERCC2
8ovarian cancer30.2TP53, XPA, ERCC2, ERCC1, ERCC3
9lung adenocarcinoma30.2TP53, XPA, ERCC1
10prostate cancer30.2TP53, XPC, ERCC5, ERCC2, ERCC4, ERCC1
11ataxia telangiectasia30.2TP53, RPA1, RPA2, XPA
12adenocarcinoma30.0TP53, XPC, XPA, ERCC2, ERCC4, ERCC1
13astrocytoma30.0TP53, XPC, ERCC2, ERCC1
14colorectal cancer29.6ERCC1, ERCC2, XPC, TP53
15breast cancer29.3DDB2, TP53, RPA1, RPA2, XPC, ERCC2
16xeroderma pigmentosum, group a11.1
17xeroderma pigmentosum, group c11.1
18xeroderma pigmentosum, group g10.9
19xeroderma pigmentosum, variant type10.8
20xeroderma pigmentosum, group b10.8
21xeroderma pigmentosum, group f10.7
22angiosarcoma10.6
23xeroderma pigmentosum type 710.6
24de sanctis-cacchione syndrome10.6
25ataxia10.6
26fanconi's anemia10.5
27prostatitis10.5
28gastric cancer10.5
29herpes simplex10.5
30chromosome xp deletion10.5
31laryngitis10.4
32neurologic diseases10.4
33cockayne syndrome type i10.4
34xeroderma pigmentosum, type 110.4
35xeroderma pigmentosum, type 910.4
36xpc-related xeroderma pigmentosum10.4
37ercc1-related xeroderma pigmentosum10.4
38xeroderma pigmentosum, group g/cockayne syndrome10.4
39bloom syndrome10.3
40progeria10.3
41dystonia10.3
42esophagitis10.3
43pterygium10.3
44uv sensitive syndrome10.3
45xeroderma pigmentosum, type 210.3
46xeroderma pigmentosum, type 310.3
47xeroderma pigmentosum, type 510.3
48xeroderma pigmentosum, type 610.3
49xpa-related xeroderma pigmentosum10.3
50ercc3-related xeroderma pigmentosum10.3

Graphical network of the top 20 diseases related to Xeroderma Pigmentosum:



Diseases related to xeroderma pigmentosum

Symptoms for Xeroderma Pigmentosum

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Clinical features from OMIM:

278720,278740,278780,278750,610651,278760,278730,278700

Drugs & Therapeutics for Xeroderma Pigmentosum

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Drug clinical trials:

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Genetic Tests for Xeroderma Pigmentosum

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Genetic tests related to Xeroderma Pigmentosum:

id Genetic test Affiliating Genes
1 Xeroderma Pigmentosum20 22 XPC
2 Xeroderma Pigmentosum Multi-Gene Panels20

Anatomical Context for Xeroderma Pigmentosum

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MalaCards organs/tissues related to Xeroderma Pigmentosum:

32
Skin, Eye, Lung, Breast, Prostate, Tongue, Liver, Lymph node, Brain, Spinal cord, Testes, B cells

Animal Models for Xeroderma Pigmentosum or affiliated genes

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Publications for Xeroderma Pigmentosum

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Articles related to Xeroderma Pigmentosum:

(show top 50)    (show all 681)
idTitleAuthorsYear
1
Invasive basal cell carcinoma in a xeroderma pigmentosum patient: facing secondary and tertiary aggressive recurrences. (24978686)
2014
2
A founder large deletion mutation in Xeroderma pigmentosum-Variant form in Tunisia: implication for molecular diagnosis and therapy. (24877075)
2014
3
Whole-exome sequencing enables rapid determination of xeroderma pigmentosum molecular etiology. (23755135)
2013
4
Postoperative neurological aggravation after anesthesia with sevoflurane in a patient with xeroderma pigmentosum: a case report. (23497518)
2013
5
The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D). (24252196)
2013
6
Three school-age cases of xeroderma pigmentosum variant type. (23651273)
2013
7
Histopathology of the inner ear in patients with xeroderma pigmentosum and neurologic degeneration. (23928520)
2013
8
Conservation of the nucleotide excision repair pathway: characterization of hydra Xeroderma Pigmentosum group F homolog. (23577191)
2013
9
Effect of Xeroderma pigmentosum complementation group F polymorphisms on gastric cancer risk and associations with H.pylori infection. (23679285)
2013
10
Hydrogen/Deuterium Exchange Reflects Binding of Human Centrin 2 to Ca(2+) and Xeroderma Pigmentosum Group C Peptide: An Example of EX1 Kinetics. (23439742)
2012
11
Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival in cisplatin/gemcitabine-treated advanced non-small cell lung cancer patients. (22052224)
2011
12
Nucleotide excision repair by mutant xeroderma pigmentosum group A (XPA) proteins with deficiency in interaction with RPA. (21148310)
2011
13
An unusual presentation of xeroderma pigmentosum in a Caucasian child. (20133220)
2010
14
Immunohistochemical prognostic criteria in xeroderma pigmentosum. (21038547)
2010
15
A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa. (20054342)
2010
16
The carboxy-terminal domain of xeroderma pigmentosum complementation group C protein, involved in TFIIH and centrin binding, is highly disordered. (18177054)
2008
17
Clone of human xeroderma pigmentosum group D cDNA and analysis of its expression and function]. (18693453)
2008
18
Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream. (18789101)
2008
19
The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1. (17967871)
2008
20
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (19008576)
2008
21
Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice. (18790090)
2008
22
Sunlight, skin cancer and vitamin D: What are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk groups? (17204418)
2007
23
Gene expression profiling of xeroderma pigmentosum. (20223010)
2006
24
Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53. (14560002)
2003
25
The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant. (12244178)
2002
26
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum variant patients. (11773631)
2002
27
UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency. (11376684)
2001
28
Topical 5-fluorouracil to treat multiple or unresectable facial squamous cell carcinomas in xeroderma pigmentosum. (11369927)
2001
29
Cockayne syndrome and xeroderma pigmentosum. (11185579)
2000
30
Mast cells in an angiosarcoma complicating xeroderma pigmentosum in a 13-year-old girl. (11044816)
2000
31
The Bowman-Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation-treated nucleotide excision repair-competent cells but not of xeroderma pigmentosum cells. (10716643)
2000
32
Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells. (10956030)
2000
33
The relative expression of mutated XPB genes results in xeroderma pigmentosum/Cockayne's syndrome or trichothiodystrophy cellular phenotypes. (10332046)
1999
34
Partial functional correction of xeroderma pigmentosum group A cells by suppressor tRNA. (10498252)
1999
35
Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein. (9422774)
1998
36
Clones of normal keratinocytes and a variety of simultaneously present epidermal neoplastic lesions contain a multitude of p53 gene mutations in a xeroderma pigmentosum patient. (9622088)
1998
37
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene. (9238033)
1997
38
Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C. (9415314)
1997
39
Truncated XPA protein detected in atypical group A xeroderma pigmentosum. (8740317)
1996
40
Xeroderma pigmentosum and molecular cloning of DNA repair genes. (8687116)
1996
41
Correlation of the clinical manifestations and gene mutations of Japanese xeroderma pigmentosum group A patients. (7577588)
1995
42
Mutation and expression of the XPA gene in revertants and hybrids of a xeroderma pigmentosum cell line. (7974007)
1994
43
Human Xeroderma pigmentosum group G gene encodes a DNA endonuclease. (8078765)
1994
44
Far less frequent mutations in ras genes than in the p53 gene in skin tumors of xeroderma pigmentosum patients. (7916998)
1994
45
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F. (8253091)
1993
46
Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients. (8319200)
1993
47
Human Xeroderma pigmentosum group D gene encodes a DNA helicase. (8413672)
1993
48
Heterozygous manifestations in four autosomal recessive human cancer-prone syndromes: ataxia telangiectasia, xeroderma pigmentosum, Fanconi anemia, and Bloom syndrome. (1279391)
1992
49
Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C. (1522891)
1992
50
Xeroderma pigmentosum and Cockayne syndrome. (662506)
1978

Variations for Xeroderma Pigmentosum

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Expression for genes affiliated with Xeroderma Pigmentosum

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Expression patterns in normal tissues for genes affiliated with Xeroderma Pigmentosum

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Pathways for genes affiliated with Xeroderma Pigmentosum

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Pathways related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ERCC2, ERCC3
2
Show member pathways
9.7ERCC1, ERCC4
3
Show member pathways
9.5ERCC2, TP53
4
Show member pathways
9.5ERCC2, TP53
59.4POLH, TP53
69.2XPC, TP53, DDB2
7
Show member pathways
Homologous recombination37
9.1RPA1, RPA2
8
Show member pathways
9.1RPA1, RPA2
9
Show member pathways
9.1RPA1, RPA2
10
Show member pathways
9.1RPA2, RPA1
11
Show member pathways
DNA damage response37
8.7DDB2, TP53, RPA2
128.7XPC, TP53, ERCC2, ERCC3, XPA
13
Show member pathways
8.5RPA1, TP53, RPA2
14
Show member pathways
8.5TP53, RPA2, RPA1
158.5TP53, RPA1, RPA2
167.9RPA2, RPA1, POLH, ERCC1, ERCC4
17
Show member pathways
6.7XPC, RPA2, TP53, ERCC2, ERCC1, DDB2
18
Show member pathways
6.4TP53, ERCC3, ERCC1, ERCC4, ERCC2, ERCC5
19
Show member pathways
6.0ERCC4, ERCC1, XPC, RPA2, RPA1, DDB2
20
Show member pathways
5.6ERCC5, ERCC2, ERCC4, ERCC1, ERCC3, XPA

Compounds for genes affiliated with Xeroderma Pigmentosum

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Compounds related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
12-acetylaminofluorene4410.2XPA, XPC
2ecteinascidin 7434410.2ERCC2, ERCC5
3phosphodiester4410.0ERCC3, ERCC5
4platinum compounds509.9ERCC1, ERCC2
5sarcnu449.8ERCC2, TP53
6psoralen449.8XPA, ERCC4, ERCC1
7n-acetoxy-2-acetylaminofluorene449.7TP53, ERCC1
8vinorelbine44 50 1111.7ERCC1, ERCC2
9leucovorin44 50 1111.6ERCC1, ERCC2
10bpde449.5RPA1, TP53
11cpds449.4DDB2, RPA1, XPA, ERCC3
12adozelesin449.4RPA2, TP53
13rpa 2449.4RPA1, RPA2
14bcnu449.4TP53, ERCC2, ERCC1
15fluorouracil50 1110.4ERCC1, ERCC2, TP53
16irinotecan44 50 1111.3TP53, ERCC2, ERCC1
17platinum44 5010.3ERCC1, ERCC2, ERCC5, POLH
18gemcitabine44 50 1111.3TP53, ERCC2, ERCC1
19vincristine44 50 1111.3TP53, ERCC2, ERCC1
207-hydroxystaurosporine44 1110.2TP53, RPA2
21docetaxel44 50 61 1112.2ERCC1, ERCC2, TP53
22benzo(a)pyrene449.1ERCC1, XPA, XPC, TP53
23mitomycin c449.1ERCC1, ERCC4, XPA, TP53
24cyclophosphamide44 50 1111.1ERCC1, ERCC4, ERCC2, TP53
255fluorouracil449.1ERCC1, ERCC4, ERCC2, TP53
26oxaliplatin44 50 1111.1TP53, XPA, ERCC2, ERCC1
27atp44 2810.0ERCC3, ERCC5, XPA, XPC, RPA1
28aphidicolin449.0TP53, RPA2
29methylmethanesulfonate449.0RPA1, TP53
30paclitaxel44 50 1110.9ERCC1, ERCC2, TP53
31melphalan44 50 1110.8ERCC3, ERCC1, ERCC4, ERCC2, TP53
32hydroxyurea44 50 1110.8RPA2, RPA1, TP53
33camptothecin44 61 1110.7RPA2, RPA1, TP53
34thymidylate448.6TP53, RPA1, ERCC2, ERCC4, ERCC1
35etoposide44 50 61 1111.3TP53, RPA1, RPA2, ERCC1
36oligonucleotide447.5TP53, RPA1, RPA2, XPC, XPA, ERCC5
37cisplatin44 50 61 119.7ERCC3, DDB2, TP53, POLH, RPA1, XPC

GO Terms for genes affiliated with Xeroderma Pigmentosum

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Cellular components related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1SSL2-core TFIIH complexGO:00044110.0ERCC3, ERCC2
2XPC complexGO:0719429.9RAD23B, XPC
3nucleotide-excision repair complexGO:0001099.8ERCC4, ERCC1
4holo TFIIH complexGO:0056759.7ERCC5, ERCC2, ERCC3
5nuclear chromosome, telomeric regionGO:0007849.4ERCC1, ERCC4
6transcription factor TFIID complexGO:0056699.2TP53, ERCC4, ERCC1
7DNA replication factor A complexGO:0056629.1RPA2, RPA1
8PML bodyGO:0166058.4TP53, RPA1, RPA2
9cytoplasmGO:0057377.4XPA, RAD23B, RPA1, TP53, ERCC2, ERCC1
10nucleolusGO:0057306.6TP53, RPA1, RPA2, XPC, XPA, RAD23B
11nucleusGO:0056346.0ERCC1, TP53, ERCC2, ERCC4, ERCC3, ERCC5
12nucleoplasmGO:0056545.2RAD23B, RPA1, RPA2, XPC, XPA, ERCC3

Biological processes related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1hair cell differentiationGO:03531510.2ERCC2, ERCC3
2nucleotide-excision repair, DNA damage recognitionGO:00071510.1XPC, RAD23B
3transcription elongation from RNA polymerase I promoterGO:00636210.1ERCC2, ERCC3
4response to UV-CGO:01022510.1ERCC5, POLH
5termination of RNA polymerase I transcriptionGO:00636310.1ERCC2, ERCC3
6transcription initiation from RNA polymerase I promoterGO:00636110.0ERCC3, ERCC2
7nucleotide-excision repair, DNA incision, 5-to lesionGO:00629610.0ERCC4, ERCC1
8negative regulation of telomere maintenanceGO:03220510.0ERCC1, ERCC4
9pyrimidine dimer repairGO:00629010.0POLH, DDB2
10regulation of mitotic cell cycle phase transitionGO:190199010.0ERCC2, ERCC3, XPC
11nucleotide-excision repair, DNA incisionGO:03368310.0ERCC2, ERCC4, ERCC3
12transcription from RNA polymerase I promoterGO:0063609.9ERCC2, ERCC3
137-methylguanosine mRNA cappingGO:0063709.8ERCC2, ERCC3
14nucleotide-excision repair, DNA incision, 3-to lesionGO:0062959.8ERCC5, ERCC1, ERCC4
15DNA-dependent DNA replicationGO:0062619.8RPA1, POLH
16DNA catabolic process, endonucleolyticGO:0007379.8ERCC5, ERCC4, ERCC1
17positive regulation of viral transcriptionGO:0504349.7ERCC3, ERCC2
18embryonic organ developmentGO:0485689.6ERCC1, TP53
19response to X-rayGO:0101659.6TP53, ERCC1
20DNA recombinase assemblyGO:0007309.5RPA1, RPA2
21nucleotide-excision repair, DNA gap fillingGO:0062979.4RPA1, RPA2
22telomere maintenance via semi-conservative replicationGO:0322019.4RPA2, RPA1
23response to oxidative stressGO:0069799.4XPA, ERCC1, ERCC3, ERCC2
24response to UVGO:0094119.3ERCC3, ERCC4, DDB2, XPA, ERCC5
25telomere maintenance via recombinationGO:0007229.3RPA1, RPA2
26protein localizationGO:0081049.3ERCC3, TP53
27DNA strand elongation involved in DNA replicationGO:0062719.2RPA1, RPA2
28telomere maintenanceGO:0007239.2RPA2, RPA1, ERCC4
29double-strand break repair via homologous recombinationGO:0007249.2ERCC4, RPA1, RPA2
30UV protectionGO:0096509.2ERCC5, ERCC2, ERCC3, ERCC4, ERCC1
31in utero embryonic developmentGO:0017019.1ERCC2, RPA1, TP53
32multicellular organism growthGO:0352649.0XPA, ERCC2, TP53, ERCC1
33cell proliferationGO:0082839.0ERCC1, ERCC2, TP53
34double-strand break repairGO:0063028.4ERCC1, RPA2, RPA1, TP53
35transcription-coupled nucleotide-excision repairGO:0062837.8RPA2, RPA1, ERCC5, ERCC2, ERCC4, ERCC1
36nucleotide-excision repair, DNA damage removalGO:0007186.4DDB2, RPA1, XPC, XPA, RAD23B, ERCC5
37DNA repairGO:0062816.0XPA, RAD23B, ERCC5, ERCC2, ERCC4, ERCC1
38nucleotide-excision repairGO:0062895.8ERCC4, ERCC2, ERCC5, ERCC1, ERCC3, RAD23B

Molecular functions related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1bubble DNA bindingGO:00040510.1XPC, ERCC5
2endodeoxyribonuclease activityGO:00452010.0ERCC5, ERCC4
3TFIID-class transcription factor bindingGO:0010949.9ERCC1, ERCC4
4RNA polymerase II carboxy-terminal domain kinase activityGO:0083539.8ERCC3, ERCC2
5single-stranded DNA endodeoxyribonuclease activityGO:0000149.8ERCC4, ERCC1
6structure-specific DNA bindingGO:0435669.8ERCC1, ERCC4
7ATP-dependent DNA helicase activityGO:0040039.7ERCC2, ERCC3
8DNA-dependent ATPase activityGO:0080949.5ERCC3, ERCC2
9protein C-terminus bindingGO:0080229.3ERCC3, ERCC4, ERCC2, ERCC1
10metal ion bindingGO:0468728.6POLH, XPA, ERCC5, ERCC2, RPA1
11protein N-terminus bindingGO:0474858.1RPA2, ERCC5, ERCC2, ERCC4, ERCC3, TP53
12single-stranded DNA bindingGO:0036977.6ERCC1, ERCC4, ERCC5, RAD23B, XPC, RPA2
13damaged DNA bindingGO:0036847.2DDB2, POLH, TP53, XPC, XPA, RAD23B
14protein bindingGO:0055155.2RAD23B, XPA, XPC, RPA2, RPA1, POLH

Products for genes affiliated with Xeroderma Pigmentosum

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3CDC
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