XP
MCID: XRD001
MIFTS: 65

Xeroderma Pigmentosum (XP) malady

Summaries for Xeroderma Pigmentosum

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Xeroderma pigmentosum (xp) is an inherited condition characterized by an extreme sensitivity to ultraviolet (uv) rays from sunlight. this condition mostly affects the eyes and areas of skin exposed to the sun. some affected individuals also have problems involving the nervous system. symptoms typically develop in infancy or early childhood. xeroderma pigmentosum is caused by mutations in genes that are involved in repairing damaged dna. inherited mutations in at least eight genes have been identified. the condition is inherited in an autosomal recessive manner. last updated: 10/21/2010

MalaCards: Xeroderma Pigmentosum, also known as de sanctis-cacchione syndrome, is related to xeroderma pigmentosum, group d and cockayne syndrome. An important gene associated with Xeroderma Pigmentosum is ERCC6 (excision repair cross-complementing rodent repair deficiency, complementation group 6), and among its related pathways are Nucleotide Excision Repair and Chks in Checkpoint Regulation. The compounds cisplatin and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has material basis in autosomal recessive inheritance of dna repair.

Genetics Home Reference:21 Xeroderma pigmentosum, which is commonly known as XP, is an inherited condition characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight. This condition mostly affects the eyes and areas of skin exposed to the sun. Some affected individuals also have problems involving the nervous system.

Wikipedia:64 Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder of DNA repair in which the... more...

Description from OMIM:47 278700, 278740, 610651, 278750, 278720 278780, 278730, 278760, 278800 more

GeneReviews summary for xp

Aliases & Classifications for Xeroderma Pigmentosum

Sources:
8Disease Ontology, 64Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 35MeSH
See all sources

Aliases & Descriptions:

xeroderma pigmentosum 8 64 19 43 20 22 21 10 45
de sanctis-cacchione syndrome 43 22 47
desanctis-cacchione syndrome 19 21
xp 43 21
xeroderma pigmentosa 43
xerodermic idiocy 43


External Ids:

Disease Ontology8 DOID:0050427
MeSH35 D014983

Related Diseases for Xeroderma Pigmentosum

Sources:
17GeneCards, 18GeneDecks
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Diseases in the xeroderma pigmentosum, variant type family:

xeroderma pigmentosum xeroderma pigmentosum type 7
xeroderma pigmentosum, type 9 xeroderma pigmentosum, type 1
xeroderma pigmentosum, type 2 xeroderma pigmentosum, type 3
xeroderma pigmentosum, type 5 xeroderma pigmentosum, type 6

Diseases related to Xeroderma Pigmentosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1xeroderma pigmentosum, group d31.8ERCC2, ERCC3
2cockayne syndrome31.6XPA, XPC, DDB2, DDB1, RAD23B, ERCC6
3squamous cell carcinoma31.1XPA, XPC, DDB2, POLH, ERCC4, ERCC1
4basal cell carcinoma31.0XPA, ERCC1, ERCC2, TP53
5fanconi's anemia30.8ERCC2, ERCC4
6ataxia telangiectasia30.7RPA2, RPA1, XPA, TP53
7xeroderma pigmentosum, group e, ddb-negative subtype30.7XPC, DDB2, DDB1
8adenocarcinoma30.6XPA, XPC, ERCC4, ERCC1, ERCC2, TP53
9bloom syndrome30.4FEN1, RECQL
10colorectal cancer30.2FEN1, XPC, ERCC1, ERCC2, TP53
11werner syndrome30.2RPA1, FEN1, RECQL
12testicular cancer30.2ERCC2, ERCC1
13xeroderma pigmentosum, group g11.4
14xeroderma pigmentosum, group c11.3
15xeroderma pigmentosum, group a11.1
16xeroderma pigmentosum, group f11.1
17xeroderma pigmentosum, group b11.0
18xeroderma pigmentosum, group g/cockayne syndrome10.9
19n syndrome10.7
20xeroderma pigmentosum, variant type10.7
21angiosarcoma10.6
22xeroderma pigmentosum type 710.6
23ataxia10.5
24chromosome xp deletion10.4
25fanconi syndrome10.4
26skin squamous cell carcinoma10.4
27cockayne syndrome type i10.4
28xeroderma pigmentosum, type 910.4
29xeroderma pigmentosum, type 110.4
30xpc-related xeroderma pigmentosum10.4
31ercc1-related xeroderma pigmentosum10.4
32progeria10.3
33t cell deficiency10.3
34char syndrome10.3
35radiation induced cancer10.3
36xeroderma pigmentosum, type 210.3
37xeroderma pigmentosum, type 310.3
38xeroderma pigmentosum, type 510.3
39xeroderma pigmentosum, type 610.3
40xpa-related xeroderma pigmentosum10.3
41ercc3-related xeroderma pigmentosum10.3
42ercc2-related xeroderma pigmentosum10.3
43ddb2-related xeroderma pigmentosum10.3
44ercc4-related xeroderma pigmentosum10.3
45ercc5-related xeroderma pigmentosum10.3
46polh-related xeroderma pigmentosum10.3
47xeroderma pigmentosum, type f/cockayne syndrome10.3
48chondrodysplasia10.2
49deficiency anemia10.2
50limbal stem cell deficiency10.2

Graphical network of the top 20 diseases related to Xeroderma Pigmentosum:



Diseases related to xeroderma pigmentosum

Clinical Features for Xeroderma Pigmentosum

Sources:
47OMIM
See all sources

Clinical features from OMIM:

278700,278740,610651,278750,278720,278780,278730,278760,278800

Clinical synopsis from OMIM:

278800

Drugs & Therapeutics for Xeroderma Pigmentosum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Xeroderma Pigmentosum

Drug clinical trials:

Search ClinicalTrials for Xeroderma Pigmentosum

Search NIH Clinical Center for Xeroderma Pigmentosum

Search CenterWatch for Xeroderma Pigmentosum

Genetic Tests for Xeroderma Pigmentosum

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Xeroderma Pigmentosum:

id Genetic test Affiliating Genes
1 Xeroderma Pigmentosum20 22 XPC
2 Xeroderma Pigmentosum Multi-gene Panels20
3 De Sanctis-cacchione Syndrome22

Anatomical Context for Xeroderma Pigmentosum

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Xeroderma Pigmentosum:

33
Skin, Liver, Tongue, Spinal cord, Brain, Lymph node, Lung, Breast, Prostate, T cells, B cells

Animal Models for Xeroderma Pigmentosum or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Xeroderma Pigmentosum

Sources:
51PubMed
See all sources

Articles related to Xeroderma Pigmentosum:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D). (24252196)
2013
2
Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA. (24051049)
2013
3
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH. (23352696)
2013
4
Impact of two common xeroderma pigmentosum group D (XPD) gene polymorphisms on risk of prostate cancer. (23028604)
2012
5
Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients. (22038723)
2012
6
The cerebro-morphological fingerprint of a progeroid syndrome: white matter changes correlate with neurological symptoms in xeroderma pigmentosum. (22363517)
2012
7
Ocular manifestations of xeroderma pigmentosum at a tertiary eye care center in Saudi Arabia. (21629134)
2011
8
Xeroderma pigmentosum variant: complementary molecular approaches to detect a 13 base pair deletion in the DNA polymerase eta gene. (21640722)
2011
9
Founder mutations in xeroderma pigmentosum. (20463673)
2010
10
Identification of a primarily neurological phenotypic expression of xeroderma pigmentosum complementation group A in a Tunisian family. (20199544)
2010
11
p53 dysfunction by xeroderma pigmentosum group C defects enhance lung adenocarcinoma metastasis via increased MMP1 expression. (21056989)
2010
12
Non-radioisotope method for diagnosing photosensitive genodermatoses and a new marker for xeroderma pigmentosum variant. (19335687)
2009
13
Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. (19586908)
2009
14
Clone of human xeroderma pigmentosum group D cDNA and analysis of its expression and function]. (18693453)
2008
15
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (19008576)
2008
16
Pilomatricoma in a case of familial xeroderma pigmentosum. (17558059)
2007
17
Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair. (17693435)
2007
18
The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germ line. (17510396)
2007
19
Gene expression profiling of xeroderma pigmentosum. (20223010)
2006
20
A novel XPA gene mutation and its functional analysis in a Japanese patient with xeroderma pigmentosum group A. (16098033)
2005
21
Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. (15964821)
2005
22
HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair. (16105547)
2005
23
Defining the function of xeroderma pigmentosum group F protein in psoralen interstrand cross-link-mediated DNA repair and mutagenesis. (14728600)
2004
24
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (14660303)
2004
25
Functional studies on the interaction between human replication protein A and Xeroderma pigmentosum group A complementing protein (XPA). (11911469)
2002
26
Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. (12376498)
2002
27
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. (11756691)
2002
28
Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients. (12499255)
2002
29
Multiple cutaneous malignancies in xeroderma pigmentosum. (17664721)
2001
30
Poisson distribution to assess actinic keratoses in xeroderma pigmentosum. (11575371)
2001
31
Relationship between posttranslational modification of transaldolase and catalase deficiency in UV-sensitive repair-deficient xeroderma pigmentosum fibroblasts and SV40-transformed human cells. (11390181)
2001
32
Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts. (11378441)
2001
33
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. (11239393)
2001
34
Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair. (10859352)
2000
35
Xeroderma pigmentosum complementation group A protein acts as a processivity factor. (10814539)
2000
36
Respective roles of cyclobutane pyrimidine dimers, (6-4)photoproducts, and minor photoproducts in ultraviolet mutagenesis of repair-deficient xeroderma pigmentosum A cells. (10749146)
2000
37
Subnuclear distribution of DNA topoisomerase I and Bax protein in normal and xeroderma pigmentosum fibroblasts after irradiation with UV light and gamma rays or treatment with topotecan. (10235474)
1999
38
The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein. (9874796)
1999
39
p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity. (9632823)
1998
40
Comparison of the rate of excision of major UV photoproducts in the strands of the human HPRT gene of normal and xeroderma pigmentosum variant cells. (8538650)
1996
41
Correlation of the clinical manifestations and gene mutations of Japanese xeroderma pigmentosum group A patients. (7577588)
1995
42
Analysis of the tumor suppressor gene p53 in xeroderma pigmentosum fibroblasts. (7923108)
1994
43
Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy. (7920640)
1994
44
Heterozygous manifestations in four autosomal recessive human cancer-prone syndromes: ataxia telangiectasia, xeroderma pigmentosum, Fanconi anemia, and Bloom syndrome. (1279391)
1992
45
Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A Xeroderma pigmentosum. (1372103)
1992
46
Xeroderma pigmentosum and Cockayne syndrome: overlapping clinical and biochemical phenotypes. (1372469)
1992
47
The XPD complementation group. Insights into xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. (1372108)
1992
48
Mutational analysis of the structure and function of the Xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair. (1601884)
1992
49
Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21. (1916809)
1991
50
Radiation-induced chromatid aberrations in Cockayne syndrome and xeroderma pigmentosum group C fibroblasts in relation to cancer predisposition. (1756475)
1991

Genetic Variations for Xeroderma Pigmentosum

Expression for genes affiliated with Xeroderma Pigmentosum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Xeroderma Pigmentosum

Search GEO for disease gene expression data for Xeroderma Pigmentosum.

Pathways for genes affiliated with Xeroderma Pigmentosum

Sources:
54Reactome, 52QIAGEN, 30KEGG, 4Cell Signaling Technology, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0XPC, DDB2, DDB1, POLH, RAD23B, ERCC6
2
Hide members
10.9XPC, POLH, RAD23B, ERCC6, ERCC4, ERCC1
3
Hide members
10.9RPA2, XPC, DDB2, DDB1, RAD23B, RAD23A
4
Hide members
10.8RPA2, RPA1, FEN1, XPC, DDB2, DDB1
5
Hide members
10.7ERCC6, ERCC4, ERCC1, ERCC3, ERCC5, ERCC2
6
Transcription P53 signaling pathway
Hide members
10.7XPA, XPC, ERCC3, ERCC2, TP53
710.6RPA2, RPA1, POLH, ERCC4, ERCC1
8
Hide members
10.6CETN2, FEN1, RPA1, RPA2
9
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.6XPC, DDB2, TP53
10
Hide members
10.6TP53, DDB2, RPA2
11
Hide members
10.6FEN1, RPA1, RPA2
12
Hide members
10.6FEN1, RPA1, RPA2
13
Hide members
10.6RPA2, RPA1, FEN1
1410.5RAD23B, XPC
1510.5TP53, ERCC2
16
Hide members
10.5TP53, ERCC2
17
Hide members
10.5RPA1, RPA2
18
Hide members
10.5RPA2, RPA1

Compounds for genes affiliated with Xeroderma Pigmentosum

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB
See all sources

Compounds related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1cisplatin45 50 60 1114.3TP53, RPA1, FEN1, XPA, XPC, DDB2
2oligonucleotide4511.1RPA2, RPA1, FEN1, XPA, XPC, ERCC1
3atp45 2912.1RPA1, FEN1, XPA, XPC, RECQL, ERCC6
4melphalan45 1112.1ERCC4, ERCC1, ERCC3, ERCC2, TP53
5thymidylate4511.0RPA1, ERCC4, ERCC1, ERCC2, TP53
6cpds4511.0RPA1, XPA, DDB2, ERCC3
75fluorouracil4511.0FEN1, ERCC4, ERCC1, ERCC2, TP53
8benzo(a)pyrene4511.0XPA, XPC, ERCC1, TP53
9oxaliplatin45 50 1113.0XPA, ERCC1, ERCC2, TP53
10mitomycin c4511.0XPA, ERCC4, ERCC1, TP53
11psoralen4511.0ERCC1, ERCC4, XPA
12cyclophosphamide45 50 1113.0TP53, ERCC2, ERCC1, ERCC4
13bcnu4510.9TP53, ERCC2, ERCC1
14platinum45 5011.9POLH, ERCC1, ERCC2
15methylmethanesulfonate4510.9TP53, FEN1, RPA1
16etoposide45 50 60 1113.9TP53, ERCC1, RPA1, RPA2
17n-acetoxy-2-acetylaminofluorene4510.9ERCC1, TP53
18adozelesin4510.9RPA2, TP53
19sarcnu4510.9TP53, ERCC2
20thymine glycol4510.9ERCC5, ERCC6
21magnesium45 11 2412.8FEN1, POLH, RECQL, ERCC4, ERCC2
22ecteinascidin 7434510.8ERCC5, ERCC2
232-acetylaminofluorene4510.8XPA, XPC
24irinotecan45 50 1112.8TP53, ERCC2, ERCC1
25platinum compounds5010.8ERCC1, ERCC2
26rpa 24510.8RPA2, RPA1
27gemcitabine45 50 1112.8TP53, ERCC2, ERCC1
28hydroxyurea45 50 1112.7RPA2, RPA1, TP53
297-hydroxystaurosporine45 1111.7TP53, RPA2
30vincristine45 50 1112.6TP53, ERCC2, ERCC1
31phosphodiester4510.6ERCC5, ERCC3
32bpde4510.5TP53, RPA1
33docetaxel45 50 60 1113.5ERCC1, ERCC2, TP53
34camptothecin45 60 1112.3TP53, RPA1, RPA2

GO Terms for genes affiliated with Xeroderma Pigmentosum

Sources:
16Gene Ontology
See all sources

Cellular components related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.3POLH, DDB1, XPC, XPA, FEN1, RPA1
2nucleoplasmGO:00565411.3TP53, RPA2, RPA1, FEN1, XPA, XPC
3nucleolusGO:00573010.9RPA2, RPA1, FEN1, POLH, RECQL, RAD23B
4XPC complexGO:07194210.8XPC, RAD23B, CETN2
5holo TFIIH complexGO:00567510.8ERCC2, ERCC5, ERCC3
6transcription factor TFIID complexGO:00566910.7ERCC4, ERCC1, TP53
7SSL2-core TFIIH complexGO:00044110.6ERCC2, ERCC3
8nucleotide-excision repair complexGO:00010910.5ERCC4, ERCC1
9nuclear chromosome, telomeric regionGO:00078410.5ERCC1, ERCC4
10DNA replication factor A complexGO:00566210.4RPA1, RPA2
11PML bodyGO:01660510.3TP53, RPA1, RPA2

Biological processes related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:00628111.5ERCC2, DDB2, DDB1, POLH, UVRAG, RECQL
2nucleotide-excision repairGO:00628911.4RPA2, RPA1, XPA, XPC, DDB2, DDB1
3nucleotide-excision repair, DNA damage removalGO:00071811.3RAD23B, ERCC4, ERCC1, ERCC3, ERCC5, ERCC2
4transcription-coupled nucleotide-excision repairGO:00628311.2RPA2, RPA1, ERCC6, ERCC4, ERCC1, ERCC3
5response to UVGO:00941111.1XPA, DDB2, ERCC6, ERCC4, ERCC3, ERCC5
6UV protectionGO:00965011.1FEN1, ERCC4, ERCC1, ERCC3, ERCC5, ERCC2
7multicellular organism growthGO:03526411.0XPA, ERCC6, ERCC1, ERCC2, TP53
8response to oxidative stressGO:00697911.0XPA, ERCC6, ERCC1, ERCC3, ERCC2
9double-strand break repairGO:00630211.0RPA2, RPA1, FEN1, ERCC1, TP53
10regulation of mitotic cell cycle phase transitionGO:190199011.0XPC, DDB1, ERCC3, ERCC2
11DNA replicationGO:00626011.0RPA2, RPA1, FEN1, POLH, RECQL
12nucleotide-excision repair, DNA incision, 3-to lesionGO:00629511.0ERCC4, ERCC1, ERCC5
13nucleotide-excision repair, DNA incisionGO:03368311.0ERCC4, ERCC3, ERCC2
14telomere maintenanceGO:00072311.0RPA2, RPA1, FEN1, ERCC4
15pyrimidine dimer repairGO:00629011.0DDB2, POLH, ERCC6
16response to X-rayGO:01016510.9TP53, ERCC1, ERCC6
17modulation by virus of host morphology or physiologyGO:01904810.9DDB1, RAD23A, ERCC3, ERCC2, TP53
18telomere maintenance via semi-conservative replicationGO:03220110.9RPA2, RPA1, FEN1
19telomere maintenance via recombinationGO:00072210.9FEN1, RPA1, RPA2
20DNA strand elongation involved in DNA replicationGO:00627110.9RPA2, RPA1, FEN1
21base-excision repairGO:00628410.9TP53, ERCC6, FEN1
22nucleotide-excision repair, DNA damage recognitionGO:00071510.9RAD23B, XPC
23nucleotide-excision repair, DNA incision, 5-to lesionGO:00629610.8ERCC1, ERCC4
24double-strand break repair via homologous recombinationGO:00072410.8RPA2, RPA1, ERCC4
25negative regulation of telomere maintenanceGO:03220510.8ERCC1, ERCC4
26DNA recombinase assemblyGO:00073010.8RPA1, RPA2
27hair cell differentiationGO:03531510.8ERCC2, ERCC3
28proteasomal ubiquitin-dependent protein catabolic processGO:04316110.7RAD23A, RAD23B, DDB1
29regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243410.7RAD23B, RAD23A
30DNA strand renaturationGO:00073310.7RECQL, TP53
31DNA recombinationGO:00631010.7ERCC1, RECQL, RPA1
32response to UV-CGO:01022510.6POLH, ERCC5
33response to UV-BGO:01022410.6XPC, ERCC6
34termination of RNA polymerase I transcriptionGO:00636310.6ERCC2, ERCC3
35DNA-dependent DNA replicationGO:00626110.4RPA1, RPA2
36transcription elongation from RNA polymerase I promoterGO:00636210.3ERCC2, ERCC3

Molecular functions related to Xeroderma Pigmentosum according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4UVRAG, POLH, DDB1, DDB2, XPC, XPA
2damaged DNA bindingGO:00368411.2TP53, FEN1, XPA, XPC, ERCC3, ERCC1
3single-stranded DNA bindingGO:00369711.0ERCC5, ERCC1, ERCC4, RAD23A, RAD23B, XPC
4protein N-terminus bindingGO:04748511.0RPA2, ERCC6, ERCC4, ERCC3, ERCC5, ERCC2
5protein C-terminus bindingGO:00802210.9ERCC6, ERCC4, ERCC1, ERCC3, ERCC2
6DNA bindingGO:00367710.9FEN1, DDB2, DDB1, RECQL, ERCC6, ERCC3
7ATP-dependent DNA helicase activityGO:00400310.8RECQL, ERCC3, ERCC2
8TFIID-class transcription factor bindingGO:00109410.8ERCC1, ERCC4
9DNA-dependent ATPase activityGO:00809410.8ERCC2, ERCC3, ERCC6
10single-stranded DNA endodeoxyribonuclease activityGO:00001410.6ERCC1
11bubble DNA bindingGO:00040510.6ERCC5, XPC
12structure-specific DNA bindingGO:04356610.5ERCC4, ERCC1
13DNA helicase activityGO:00367810.5ERCC6, RECQL
14endodeoxyribonuclease activityGO:00452010.5ERCC4, ERCC5
15RNA polymerase II carboxy-terminal domain kinase activityGO:00835310.3ERCC2, ERCC3

Products for genes affiliated with Xeroderma Pigmentosum

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Sources for Xeroderma Pigmentosum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet